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https://www.readbyqxmd.com/read/28429148/an-observational-time-and-motion-study-of-denosumab-subcutaneous-injection-and-zoledronic-acid-intravenous-infusion-in-patients-with-metastatic-bone-disease-results-from-three-european-countries
#1
Jean-Jacques Body, Francesca Gatta, Erwin De Cock, Sunning Tao, Persefoni Kritikou, Pauline Wimberger, Jeroen Mebis, Marc Peeters, Paolo Pedrazzoli, Augusto Caraceni, Vincenzo Adamo, Guy Hechmati
PURPOSE: Denosumab (administered via subcutaneous injection) demonstrated superior efficacy versus the intravenously administered zoledronic acid in the prevention of skeletal-related events in an integrated analysis of three head-to-head phase III trials in patients with bone metastases secondary to solid tumors. To date, no studies have evaluated treatment administration duration endpoints of these two agents. METHODS: A multinational, multi-site, observational time and motion study conducted in 10 day oncology units (DOUs) across Belgium, Germany, and Italy...
April 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28360852/self-organized-behavior-generation-for-musculoskeletal-robots
#2
Ralf Der, Georg Martius
With the accelerated development of robot technologies, control becomes one of the central themes of research. In traditional approaches, the controller, by its internal functionality, finds appropriate actions on the basis of specific objectives for the task at hand. While very successful in many applications, self-organized control schemes seem to be favored in large complex systems with unknown dynamics or which are difficult to model. Reasons are the expected scalability, robustness, and resilience of self-organizing systems...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28297435/simple-quality-assurance-method-of-dynamic-tumor-tracking-with-the-gimbaled-linac-system-using-a-light-field
#3
Hideharu Miura, Shuichi Ozawa, Masahiro Hayata, Shintaro Tsuda, Kiyoshi Yamada, Yasushi Nagata
We proposed a simple visual method for evaluating the dynamic tumor tracking (DTT) accuracy of a gimbal mechanism using a light field. A single photon beam was set with a field size of 30×30 mm2 at a gantry angle of 90°. The center of a cube phantom was set up at the isocenter of a motion table, and 4D modeling was performed based on the tumor and infrared (IR) marker motion. After 4D modeling, the cube phantom was replaced with a sheet of paper, which was placed perpendicularly, and a light field was projected on the sheet of paper...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291934/electromagnetic-tracking-emt-technology-for-improved-treatment-quality-assurance-in-interstitial-brachytherapy
#4
Markus Kellermeier, Jens Herbolzheimer, Stephan Kreppner, Michael Lotter, Vratislav Strnad, Christoph Bert
Electromagnetic Tracking (EMT) is a novel technique for error detection and quality assurance (QA) in interstitial high dose rate brachytherapy (HDR-iBT). The purpose of this study is to provide a concept for data acquisition developed as part of a clinical evaluation study on the use of EMT during interstitial treatment of breast cancer patients. The stability, accuracy, and precision of EMT-determined dwell positions were quantified. Dwell position reconstruction based on EMT was investigated on CT table, HDR table and PDR bed to examine the influence on precision and accuracy in a typical clinical workflow...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28256025/development-of-allocentric-spatial-recall-from-new-viewpoints-in-virtual-reality
#5
James Negen, Edward Heywood-Everett, Hannah E Roome, Marko Nardini
Using landmarks and other scene features to recall locations from new viewpoints is a critical skill in spatial cognition. In an immersive virtual reality task, we asked children 3.5-4.5 years old to remember the location of a target using various cues. On some trials they could use information from their own self-motion. On some trials they could use a view match. In the very hardest kind of trial, they were 'teleported' to a new viewpoint and could only use an allocentric spatial representation. This approach provides a strict test for allocentric coding (without either a matching viewpoint or self-motion information) while avoiding additional task demands in previous studies (it does not require them to deal with a small table-top environment or to manage stronger cue conflicts)...
March 2, 2017: Developmental Science
https://www.readbyqxmd.com/read/28243999/physiological-effects-of-early-incremental-mobilization-of-a-patient-with-acute-intracerebral-and-intraventricular-hemorrhage-requiring-dual-external-ventricular-drainage
#6
Sowmya Kumble, Elizabeth K Zink, Mackenzie Burch, Sandra Deluzio, Robert D Stevens, Mona N Bahouth
BACKGROUND: Recent trials have challenged the notion that very early mobility benefits patients with acute stroke. It is unclear how cerebral autoregulatory impairments, prevalent in this population, could be affected by mobilization. The safety of mobilizing patients who have external ventricular drainage (EVD) devices for cerebrospinal fluid diversion and intracranial pressure (ICP) monitoring is another concern due to risk of device dislodgment and potential elevation in ICP. We report hemodynamic and ICP responses during progressive, device-assisted mobility interventions performed in a critically ill patient with intracerebral hemorrhage (ICH) requiring two EVDs...
February 27, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28242957/shake-table-testing-of-an-elevator-system-in-a-full-scale-five-story-building
#7
Xiang Wang, Tara C Hutchinson, Rodrigo Astroza, Joel P Conte, José I Restrepo, Matthew S Hoehler, Waldir Ribeiro
This paper investigates the seismic performance of a functional traction elevator as part of a full-scale five-story building shake table test program. The test building was subjected to a suite of earthquake input motions of increasing intensity, first while the building was isolated at its base, and subsequently while it was fixed to the shake table platen. In addition, low-amplitude white noise base excitation tests were conducted while the elevator system was placed in three different configurations, namely, by varying the vertical location of its cabin and counterweight, to study the acceleration amplifications of the elevator components due to dynamic excitations...
March 2017: Earthquake Engineering & Structural Dynamics
https://www.readbyqxmd.com/read/28239605/low-dimensional-synergistic-representation-of-bilateral-reaching-movements
#8
Martin K Burns, Vrajeshri Patel, Ionut Florescu, Kishore V Pochiraju, Ramana Vinjamuri
Kinematic and neuromuscular synergies have been found in numerous aspects of human motion. This study aims to determine how effectively kinematic synergies in bilateral upper arm movements can be used to replicate complex activities of daily living (ADL) tasks using a sparse optimization algorithm. Ten right-handed subjects executed 18 rapid and 11 natural-paced ADL tasks requiring bimanual coordination while sitting at a table. A position tracking system was used to track the subjects' arms in space, and angular velocities over time for shoulder abduction, shoulder flexion, shoulder internal rotation, and elbow flexion for each arm were computed...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28218455/experimental-evaluation-of-magnified-haptic-feedback-for-robot-assisted-needle-insertion-and-palpation
#9
Leonardo Meli, Claudio Pacchierotti, Domenico Prattichizzo
BACKGROUND: Haptic feedback has been proven to play a key role in enhancing the performance of teleoperated medical procedures. However, due to safety issues, commercially-available medical robots do not currently provide the clinician with haptic feedback. METHODS: This work presents the experimental evaluation of a teleoperation system for robot-assisted medical procedures able to provide magnified haptic feedback to the clinician. Forces registered at the operating table are magnified and provided to the clinician through a 7-DoF haptic interface...
February 20, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28210341/a-multidisciplinary-investigation-of-the-effects-of-competitive-state-anxiety-on-serve-kinematics-in-table-tennis
#10
Vuong Ngo, Hugh Richards, Miran Kondric
Displays of anxiety in table tennis were assessed through subjective (a self-report questionnaire), physiological (heart-rate variability) and kinematic variables. Using a within-group crossover design, 9 university-level table tennis players completed a series of serves under low- and high-anxiety conditions. Anxiety manipulation was achieved through the introduction of a national standard table tennis player, known to the participants, to receive serves in the high-anxiety condition, whilst serves were received by no opponent in the low-anxiety condition...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28210337/extraction-of-knowledge-from-the-topographic-attentive-mapping-network-and-its-application-in-skill-analysis-of-table-tennis
#11
Isao Hayashi, Masanori Fujii, Toshiyuki Maeda, Jasmin Leveille, Tokio Tasaka
The Topographic Attentive Mapping (TAM) network is a biologically-inspired classifier that bears similarities to the human visual system. In case of wrong classification during training, an attentional top-down signal modulates synaptic weights in intermediate layers to reduce the difference between the desired output and the classifier's output. When used in a TAM network, the proposed pruning algorithm improves classification accuracy and allows extracting knowledge as represented by the network structure...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28210336/effect-of-changing-table-tennis-ball-material-from-celluloid-to-plastic-on-the-post-collision-ball-trajectory
#12
Yuki Inaba, Sho Tamaki, Haruhiko Ikebukuro, Koshi Yamada, Hiroki Ozaki, Kazuto Yoshida
The official material used in table tennis balls was changed from celluloid to plastic, a material free of celluloid, in 2014. The purpose of this study was to understand the differences and similarities in the two types of ball materials by comparing their behavior upon collision with a table. The behavior of the balls before and after collision with a table, at various initial speeds ranging from 15 to 115 km/h, was captured using high-speed cameras. Velocities and spin rates before collision and velocities after collision were computed to calculate the coefficients of restitution and friction...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28203602/hamstring-contracture-after-acl-reconstruction-is-associated-with-an-increased-risk-of-cyclops-syndrome
#13
Francisco Guerra Pinto, Mathieu Thaunat, Matt Daggett, Charles Kajetanek, Tiago Marques, Tales Guimares, Bénédicte Quelard, Bertrand Sonnery-Cottet
BACKGROUND: Cyclops syndrome is characterized by loss of terminal knee extension due to proliferative fibrous nodule formation in the intercondylar notch. This complication occurs in the early postoperative period after anterior cruciate ligament reconstruction (ACLR). The pathogenesis of Cyclops syndrome is not well understood. HYPOTHESIS: Persistent hamstring contracture after ACLR is associated with an increased risk of subsequent Cyclops syndrome. STUDY DESIGN: Case-control study; Level of evidence, 3...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28197849/effect-of-myofascial-techniques-for-treatment-of-upper-limb-dysfunctions-in-breast-cancer-survivors-randomized-controlled-trial
#14
An De Groef, Marijke Van Kampen, Nele Verlvoesem, Evi Dieltjens, Lore Vos, Tessa De Vrieze, Marie-Rose Christiaens, Patrick Neven, Inge Geraerts, Nele Devoogdt
PURPOSE: Besides pain, myofascial dysfunctions may contribute to the presence of upper limb impairments such as impaired range of motion, decreased strength, lymphedema, and altered postures and kinematics. Therefore, the aim of this study was to investigate the effect of myofascial therapy in addition to a standard physical therapy program for treatment of upper limb dysfunctions in breast cancer survivors. METHODS: Fifty women treated for a unilateral breast cancer with pain and myofascial dysfunctions at the upper limb region...
February 14, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28157790/physical-design-factors-contributing-to-patient-falls
#15
Debajyoti Pati, Shabboo Valipoor, Aimee Cloutier, James Yang, Patricia Freier, Thomas E Harvey, Jaehoon Lee
OBJECTIVES: The aim of this study was to identify physical design elements that contribute to potential falls in patient rooms. METHODS: An exploratory, physical simulation-based approach was adopted for the study. Twenty-seven subjects, older than 70 years (11 male and 16 female subjects), conducted scripted tasks in a mockup of a patient bathroom and clinician zone. Activities were captured using motion-capture technology and video recording. After biomechanical data processing, video clips associated with potential fall moments were extracted and then examined and coded by a group of registered nurses and health care designers...
February 3, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28107235/an-experimental-biomechanical-study-on-artificial-atlantoodontoid-joint-replacement-in-dogs
#16
Quanjin Zang, Yanming Liu, Dengfeng Wang, Haopeng Li, Pinglin Yang, Dong Wang, Xijing He
STUDY DESIGN: This study tested the biomechanics of artificial atlantoodontoid joint replacement (AAOJR) in a dog model. Dogs were divided into the artificial AAOJR group (n=10), the decompression group (n=10), and the healthy control group (n=10) using a random number table. OBJECTIVE: To evaluate whether the use of AAOJR for repair of atlantoaxial instability retains rotation and restores stability. SUMMARY OF BACKGROUND DATA: Atlantoaxial instability is characterized by excessive movement or laxity at the junction between the atlas (C1) and axis (C2)...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28097277/combining-the-spin-separated-exact-two-component-relativistic-hamiltonian-with-the-equation-of-motion-coupled-cluster-method-for-the-treatment-of-spin-orbit-splittings-of-light-and-heavy-elements
#17
Zhanli Cao, Zhendong Li, Fan Wang, Wenjian Liu
The spin-separated exact two-component (X2C) relativistic Hamiltonian [sf-X2C+so-DKHn, J. Chem. Phys., 2012, 137, 154114] is combined with the equation-of-motion coupled-cluster method with singles and doubles (EOM-CCSD) for the treatment of spin-orbit splittings of open-shell molecular systems. Scalar relativistic effects are treated to infinite order from the outset via the spin-free part of the X2C Hamiltonian (sf-X2C), whereas the spin-orbit couplings (SOC) are handled at the CC level via the first-order Douglas-Kroll-Hess (DKH) type of spin-orbit operator (so-DKH1)...
February 1, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28095857/real-time-inverse-kinematics-for-the-upper-limb-a-model-based-algorithm-using-segment-orientations
#18
Bence J Borbély, Péter Szolgay
BACKGROUND: Model based analysis of human upper limb movements has key importance in understanding the motor control processes of our nervous system. Various simulation software packages have been developed over the years to perform model based analysis. These packages provide computationally intensive-and therefore off-line-solutions to calculate the anatomical joint angles from motion captured raw measurement data (also referred as inverse kinematics). In addition, recent developments in inertial motion sensing technology show that it may replace large, immobile and expensive optical systems with small, mobile and cheaper solutions in cases when a laboratory-free measurement setup is needed...
January 17, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28048909/su-f-p-36-automation-of-linear-accelerator-star-shot-measurement-with-advanced-xml-scripting-and-electronic-portal-imaging-device
#19
N Nguyen, N Knutson, M Schmidt, M Price
PURPOSE: To verify a method used to automatically acquire jaw, MLC, collimator and couch star shots for a Varian TrueBeam linear accelerator utilizing Developer Mode and an Electronic Portal Imaging Device (EPID). METHODS: An XML script was written to automate motion of the jaws, MLC, collimator and couch in TrueBeam Developer Mode (TBDM) to acquire star shot measurements. The XML script also dictates MV imaging parameters to facilitate automatic acquisition and recording of integrated EPID images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048431/su-f-t-466-an-enhanced-daily-quality-assurance-process-for-a-six-degrees-of-freedom-robotic-table
#20
E Kremmel, L Doyle, Y Yu, A Harrison
PURPOSE: A Varian PerfectPitch six degrees of freedom robotic table necessitates daily quality assurance (QA). Therapists were credentialed for this QA procedure which was easily incorporated into the existing daily warmup process. This procedure adds depth to TG-142 requirements without additional morning time costs. METHODS: This PerfectPitch table QA introduces a consistent rotation of the QUASAR™ Penta-Guide phantom and requires automatic table corrections through image fusions...
June 2016: Medical Physics
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