keyword
https://read.qxmd.com/read/38415591/conversion-of-phytochemicals-by-lactobacilli-phospho-%C3%AE-glucosidases-are-specific-for-glucosylated-phytochemicals-rather-than-disaccharides
#21
JOURNAL ARTICLE
Monika Dymarska, Anna Widenmann, Kristin E Low, D Wade Abbott, Leluo Guan, Michael G Gänzle
Food-fermenting lactobacilli convert glycosylated phytochemicals to glycosyl hydrolases and thereby alter their biological activity. This study aimed to investigate the microbial transformation of β-glucosides of phytochemicals in comparison with utilization of cellobiose. Four homofermentative and four heterofermentative lactobacilli were selected to represent the metabolic diversity of Lactobacillaceae . The genomes of Lactobacillus crispatus , Companilactobacillus paralimentarius , Lacticaseibacillus paracasei , and Lactiplantibacillus plantarum encoded for 8 to 22 enzymes, predominantly phospho-β-glucosidases, with predicted activity on β-glucosides...
February 28, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38408515/phenolics-and-flavonoids-from-polygonum-posumbu-and-comparision-of-flavonoid-compounds-content-in-different-tissues-leaves-stems-and-roots
#22
JOURNAL ARTICLE
Premi Devi Pukhrambam, Khomdram Khedashwori Devi, Chingoileima Maibam, Roseeta Devi Mutum, Moirangthem Lakshmipriyari Devi, Sudripta Das
The growing global need for antioxidative phenolics and flavonoids for maintenance of human health resulted into search of new sustainable unexplored medicinal plants used by the traditional healers for various ailments. Many synthetic based products of phenolics and flavonoids have been used, however the demand of eco-friendly, natural herbal based products are increasing. As a result, the current study aims to explore traditional potential of Polygonum posumbu related to its phenolics and flavonoids. Optimization of extraction parameters were employed which includes: solvent selection (water, ethanol, methanol, acetone and ethyl acetate), ethanol composition (40-100%), solvent to sample ratio (30-70 ml/g), temperature (50-80 °C) and time (1-5 h)...
February 24, 2024: Fitoterapia
https://read.qxmd.com/read/38402365/dissecting-the-genetic-overlap-between-severe-mental-disorders-and-markers-of-cellular-aging-identification-of-pleiotropic-genes-and-druggable-targets
#23
JOURNAL ARTICLE
Claudia Pisanu, Donatella Congiu, Anna Meloni, Pasquale Paribello, George P Patrinos, Giovanni Severino, Raffaella Ardau, Caterina Chillotti, Mirko Manchia, Alessio Squassina
Patients with severe mental disorders such as bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) show a substantial reduction in life expectancy, increased incidence of comorbid medical conditions commonly observed with advanced age and alterations of aging hallmarks. While severe mental disorders are heritable, the extent to which genetic predisposition might contribute to accelerated cellular aging is not known. We used bivariate causal mixture models to quantify the trait-specific and shared architecture of mental disorders and 2 aging hallmarks (leukocyte telomere length [LTL] and mitochondrial DNA copy number), and the conjunctional false discovery rate method to detect shared genetic loci...
February 24, 2024: Neuropsychopharmacology
https://read.qxmd.com/read/38397416/identifying-ogn-as-a-biomarker-covering-multiple-pathogenic-pathways-for-diagnosing-heart-failure-from-machine-learning-to-mechanism-interpretation
#24
JOURNAL ARTICLE
Yihao Zhu, Bin Chen, Yao Zu
BACKGROUND: The pathophysiologic heterogeneity of heart failure (HF) necessitates a more detailed identification of diagnostic biomarkers that can reflect its diverse pathogenic pathways. METHODS: We conducted weighted gene and multiscale embedded gene co-expression network analysis on differentially expressed genes obtained from HF and non-HF specimens. We employed a machine learning integration framework and protein-protein interaction network to identify diagnostic biomarkers...
February 2, 2024: Biomolecules
https://read.qxmd.com/read/38397051/efficacy-of-a-combination-therapy-with-laronidase-and-genistein-in-treating-mucopolysaccharidosis-type-i-in-a-mouse-model
#25
JOURNAL ARTICLE
Marcelina Malinowska, Wioletta Nowicka, Anna Kloska, Grzegorz Węgrzyn, Joanna Jakóbkiewicz-Banecka
Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder caused by α-L-iduronidase deficiency. The standard treatment, enzyme replacement therapy with laronidase, has limited effectiveness in treating neurological symptoms due to poor blood-brain barrier penetration. An alternative is substrate reduction therapy using molecules, such as genistein, which crosses this barrier. This study evaluated the effectiveness of a combination of laronidase and genistein in a mouse model of MPS I. Over 12 weeks, MPS I and wild-type mice received laronidase, genistein, or both...
February 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38389526/genistein-is-effective-in-inhibiting-orf-virus-infection-in-vitro-by-targeting-viral-rna-polymerase-subunit-rpo30-protein
#26
JOURNAL ARTICLE
Pin Lv, Ziyu Fang, Jiyu Guan, Lijun Lv, Mengshi Xu, Xingyuan Liu, Zhuomei Li, Yungang Lan, Zi Li, Huijun Lu, Deguang Song, Wenqi He, Feng Gao, Dacheng Wang, Kui Zhao
Orf virus (ORFV), a typical member of the genus Parapoxvirus, Poxvirus family, causes a contagious pustular dermatitis in sheep, goats, and humans. Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out viral gene expression in the host cytoplasm, which is a viral factor essential to poxvirus replication. Due to its vital role in viral life, vRNAP has emerged as one of the potential drug targets. In the present study, we investigated the antiviral effect of genistein against ORFV infection...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38380011/genistein-and-sex-hormone-treatment-alleviated-hepatic-fat-accumulation-and-inflammation-in-orchidectomized-rats-with-nonalcoholic-steatohepatitis
#27
JOURNAL ARTICLE
Fatist Okrit, Maneerat Chayanupatkul, Natcha Wanpiyarat, Prasong Siriviriyakul, Duangporn Werawatganon
Testosterone deficiency has been reported to accelerate nonalcoholic fatty liver disease (NAFLD). However, there are minimal data on the risk of NAFLD in transgender women and the treatment of NAFLD in this population. This study aimed to investigate the treatment effects and the mechanisms of action of genistein and sex hormones in orchiectomized (ORX) rats with nonalcoholic steatohepatitis (NASH) induced by a high fat high fructose diet (HFHF). Seven-week old male Sprague-Dawley rats were randomly divided into 7 groups (n = 6 each group); 1) control group, 2) ORX + standard diet group, 3) HFHF group, 4) ORX + HFHF group, 5) ORX + HFHF diet + testosterone group (50 mg/kg body weight (BW) once weekly), 6) ORX + HFHF diet + estradiol group (1...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38378612/a-network-based-drug-prioritization-and-combination-analysis-for-the-mek5-erk5-pathway-in-breast-cancer
#28
JOURNAL ARTICLE
Regan Odongo, Asuman Demiroglu-Zergeroglu, Tunahan Çakır
BACKGROUND: Prioritizing candidate drugs based on genome-wide expression data is an emerging approach in systems pharmacology due to its holistic perspective for preclinical drug evaluation. In the current study, a network-based approach was proposed and applied to prioritize plant polyphenols and identify potential drug combinations in breast cancer. We focused on MEK5/ERK5 signalling pathway genes, a recently identified potential drug target in cancer with roles spanning major carcinogenesis processes...
February 21, 2024: BioData Mining
https://read.qxmd.com/read/38363307/polyphenol-exposure-of-mothers-and-infants-assessed-by-lc-ms-ms-based-biomonitoring-in-breast-milk
#29
JOURNAL ARTICLE
Sabrina Berger, Ian Oesterle, Kolawole I Ayeni, Chibundu N Ezekiel, Annette Rompel, Benedikt Warth
Exposure to polyphenols is relevant throughout critical windows of infant development, including the breastfeeding phase. However, the quantitative assessment of polyphenols in human breast milk has received limited attention so far, though polyphenols may positively influence infant health. Therefore, a targeted LC-MS/MS assay was developed to investigate 86 analytes representing different polyphenol classes in human breast milk. The sample preparation consisted of liquid extraction, salting out, freeze-out, and a dilution step...
February 16, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38353688/retraction-note-effects-of-genistein-on-pentylenetetrazole-induced-behavioral-and-neurochemical-deficits-in-ovariectomized-rats
#30
Amr A Elsayed, Esther T Menze, Mariane G Tadros, Bassant M M Ibrahim, Nagwa A Sabri, Amani E Khalifa
No abstract text is available yet for this article.
February 14, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38346749/the-effect-of-soy-isoflavones-in-brain-development-the-emerging-role-of-multiple-signaling-pathways-and-future-perspectives
#31
JOURNAL ARTICLE
Winda Ariyani, Noriyuki Koibuchi
Soybean is a source of protein, fibers, and phytochemical isoflavones which are considered to have numerous health benefits for children and adulthood. On the other hand, isoflavones are widely known as phytoestrogens that exert their action via the estrogen signaling pathway. With this regard, isoflavones are also considered as endocrine-disrupting chemicals. Endogenous estrogen plays a crucial role in brain development through binding to estrogen receptors (ERs) or G protein-coupled estrogen receptors 1 (GPER1) and regulates morphogenesis, migration, functional maturation, and intracellular metabolism of neurons and glial cells...
February 10, 2024: Endocrine Journal
https://read.qxmd.com/read/38338349/highly-promiscuous-flavonoid-di-o-glycosyltransferases-from-carthamus-tinctorius-l
#32
JOURNAL ARTICLE
Xiaoyu Xu, Meng Xia, Yang Han, Honghu Tan, Yanying Chen, Xinqi Song, Shijun Yuan, Yifeng Zhang, Ping Su, Luqi Huang
Safflower ( Carthamus tinctorius L.) has been recognized for its medicinal value, but there have been limited studies on the glycosyltransferases involved in the biosynthesis of flavonoid glycosides from safflower. In this research, we identified two highly efficient flavonoid O -glycosyltransferases, CtOGT1 and CtOGT2 , from safflower performing local BLAST alignment. By constructing a prokaryotic expression vector, we conducted in vitro enzymatic reactions and discovered that these enzymes were capable of catalyzing two-step O -glycosylation using substrates such as kaempferol, quercetin, and eriodictyol...
January 26, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38332678/effect-of-genistein-and-coenzyme-q10-in-oxidative-damage-and-mitochondrial-membrane-potential-in-an-attenuated-type-ii-mucopolysaccharidosis-cellular-model
#33
JOURNAL ARTICLE
Camila Aguilar Delgado, Edina Poletto, Luisa Natalia Pimentel Vera, Carlos Eduardo Diaz Jacques, Priscila Vianna, Luiza Steffens Reinhardt, Guilherme Baldo, Carmen Regla Vargas
Mucopolysaccharidosis type II (MPS II) is an inborn error of the metabolism resulting from several possible mutations in the gene coding for iduronate-2-sulfatase (IDS), which leads to a great clinical heterogeneity presented by these patients. Many studies demonstrate the involvement of oxidative stress in the pathogenesis of inborn errors of metabolism, and mitochondrial dysfunction and oxidative stress can be related since most of reactive oxygen species come from mitochondria. Cellular models have been used to study different diseases and are useful in biochemical research to investigate them in a new promising way...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38310207/free-radical-scavenging-and-anti-isolated-human-ldl-oxidation-activities-of-butea-superba-roxb-extract
#34
JOURNAL ARTICLE
Kittipot Sirichaiwetchakoon, Griangsak Eumkeb
BACKGROUND: Butea superba Roxb. (B. superba), is an herbal plant traditionally used for rejuvenation. Additionally, there have been reports on its antioxidant properties. Low-density lipoproteins (LDL) oxidation is the leading cause of cardiovascular diseases (CVDs). Natural products with antioxidant properties have the potential to inhibit LDL oxidation. However, no work has been done about the anti-isolated human LDL oxidation of B. superba extract (BSE). This study aimed to investigate the antioxidant potential of BSE and its ability to prevent isolated human (LDL) oxidation induced by free radical agents...
February 3, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38304042/genistein-ameliorated-vascular-endothelial-growth-factor-a-vegf-a-and-estrogen-receptor-alpha-er-%C3%AE-in-endometriosis-mice-model-in-vivo-and-in-silico
#35
JOURNAL ARTICLE
Sutrisno Sutrisno, Maharani Maharani
Endometriosis (EM) is a gynecological disorder that causes morbidity in women and is characterized by endometrial tissue in the uterus cavity. This study investigated the mechanism of genistein in the VEGF-A and ER- α expression through in vivo and in silico approaches. An in vivo study was conducted by thirty-six mice that were divided into six groups including control, EM, and EM treatment with genistein with the doses of 1.3, 1.95, 2.6, and 3.25 mg/day for 14 days. Peritoneal tissues with lesions were collected and analyzed by immunohistochemistry to measure the VEGF-A and ER- α expression...
2024: TheScientificWorldJournal
https://read.qxmd.com/read/38301555/saline-as-solvent-and-ethanol-based-purification-process-for-the-extraction-of-proteins-and-isoflavones-from-wet-okara
#36
JOURNAL ARTICLE
Rafaela T Privatti, Maria C Capellini, Keila K Aracava, Silvana M P Pugine, Mariza P de Melo, Christianne E C Rodrigues
Okara, the solid byproduct of water-soluble soybean extract production, is a potential source of proteins and isoflavones. This study investigated different experimental configurations for extracting these compounds from wet okara, including lipid removal with ethanol at different stages of the recovery process, sequential crosscurrent extraction, and using a saline MgCl2 solution as the solvent. Three washes with a 60:40 ethanol:water (w/w) solution after isoelectric precipitation significantly increased protein content by reducing lipid content (60 %)...
January 28, 2024: Food Chemistry
https://read.qxmd.com/read/38293783/epigenetics-in-obesity-mechanisms-and-advances-in-therapies-based-on-natural-products
#37
REVIEW
Peng Chen, Yulai Wang, Fuchao Chen, Benhong Zhou
Obesity is a major risk factor for morbidity and mortality because it has a close relationship to metabolic illnesses, such as diabetes, cardiovascular diseases, and some types of cancer. With no drugs available, the mainstay of obesity management remains lifestyle changes with exercise and dietary modifications. In light of the tremendous disease burden and unmet therapeutics, fresh perspectives on pathophysiology and drug discovery are needed. The development of epigenetics provides a compelling justification for how environmental, lifestyle, and other risk factors contribute to the pathogenesis of obesity...
February 2024: Pharmacology Research & Perspectives
https://read.qxmd.com/read/38292119/soy-isoflavone-genistein-attenuates-the-efficacy-of-immune-checkpoint-therapy-in-c57bl-6-mice-inoculated-with-b16f1-melanoma-and-a-high-pd-l1-expression-level-reflects-tumor-resistance
#38
JOURNAL ARTICLE
Mako Yamamoto, Yuko Tanaka, Risako Takeda, Akiko Nakamoto, Mariko Nakamoto, Hideo Yagita, Tohru Sakai
Immune checkpoint therapy has been shown to be an effective therapy for many types of tumors. Much attention has been paid to the development of an effector target would be helpful for immune checkpoint therapy. Genistein has been shown to have an anti-tumor effect both in vitro and in vivo . In this study, we examined the effect of genistein on immune checkpoint blockade therapy against B16F1 melanoma tumors. Mice treated with genistein or anti-programmed death (PD)-1 antibody showed a significant decrease in tumor growth...
January 2024: Journal of Clinical Biochemistry and Nutrition
https://read.qxmd.com/read/38281161/indole-alkaloid-production-by-the-halo-blight-bacterium-treated-with-the-phytoalexin-genistein
#39
JOURNAL ARTICLE
Bret Cooper, Ronghui Yang, Kimberly B Campbell
When Pseudomonas savastanoi pv. phaseolicola , the bacterium that causes halo blight, induces hypersensitive immunity in common bean leaves, salicylic acid and phytoalexins accumulate at the site of infection. Both salicylic acid and the phytoalexin resveratrol exert antibiotic activities and toxicities in vitro , adversely disrupting the P. savastanoi pv. phaseolicola proteome and metabolism and stalling replication and motility. These efficacious properties likely contribute to the cessation of bacterial spread in beans...
January 28, 2024: Phytopathology
https://read.qxmd.com/read/38277755/drug-resistance-mechanisms-in-dopamine-agonist-resistant-prolactin-pituitary-neuroendocrine-tumors-and-exploration-for-new-drugs
#40
JOURNAL ARTICLE
Jianhua Cheng, Weiyan Xie, Yiyuan Chen, Yingxuan Sun, Lei Gong, Hongyun Wang, Chuzhong Li, Yazhuo Zhang
BACKGROUND: The treatment of dopamine agonists (DA) resistant prolactinomas remains a formidable challenge, as the mechanism of resistance is still unclear, and there are currently no viable alternative drug therapies available. This study seeks to investigate the mechanism of DA resistance in prolactinomas and identify new potentially effective drugs. METHODS: To explore the mechanism of DA resistance in prolactinomas, this study conducted transcriptome sequencing analysis on 27 cases of DA-resistant prolactinomas and 10 cases of sensitive prolactinomas...
January 19, 2024: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
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