Pin Lv, Ziyu Fang, Jiyu Guan, Lijun Lv, Mengshi Xu, Xingyuan Liu, Zhuomei Li, Yungang Lan, Zi Li, Huijun Lu, Deguang Song, Wenqi He, Feng Gao, Dacheng Wang, Kui Zhao
Orf virus (ORFV), a typical member of the genus Parapoxvirus, Poxvirus family, causes a contagious pustular dermatitis in sheep, goats, and humans. Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out viral gene expression in the host cytoplasm, which is a viral factor essential to poxvirus replication. Due to its vital role in viral life, vRNAP has emerged as one of the potential drug targets. In the present study, we investigated the antiviral effect of genistein against ORFV infection...
2024: Frontiers in Microbiology