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https://www.readbyqxmd.com/read/28106344/fast-separation-of-flavonoids-by-supercritical-fluid-chromatography-using-a-column-packed-with-a-sub-2%C3%A2-%C3%AE-m-particle-stationary-phase
#1
Bo Wang, Xiao-Hua Liu, Wei Zhou, Yan Hong, Shi-Lan Feng
The purpose of this study was to compare the effects of different chromatographic columns for the separation of seven flavonoids. Four different stationary phases are available, including BEH, BEH 2-EP, CSH fluorophenyl and HSS C18 SB. The analytes included calycosin, genistein, medicarpin, calycosin-7-O-β-d-glucoside, formononetin, formononetin-7-O-β-d-glucoside and liquiritigenin. The CSH fluorophenyl column was determined to be the most suitable and provided the fastest separation within 17 min using gradient elution with carbon dioxide as the mobile phase and methanol as the co-solvent...
January 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28102743/expression-and-alteration-of-bkca-channels-in-the-sphincter-of-oddi-s-from-rabbits-with-hypercholesterolemia
#2
Dan Feng, Haiyan Nan, Wen Wang, Linfeng Yan, Pang Du, Lin Zuo, Kun Zhang, Minggao Zhao, Guangbin Cui
This study aimed to investigate the expression and function of BKCa channels in the Sphincter of Oddi (SO) in a rabbit model of hypercholesterolemia (HC). New Zealand white rabbits were randomly divided into two groups: the control group was fed standard chow (n = 18) whereas the high-cholesterol group was fed cholesterol-enriched chow containing 1.5% cholesterol (n = 18). The serum cholesterol level was significantly greater in the HC groups than in the control group, but there was no significant difference in body weight between the control and HC groups...
January 19, 2017: Channels
https://www.readbyqxmd.com/read/28096960/estrogen-agonist-genistein-differentially-influences-the-cognitive-and-motor-disorders-in-an-ovariectomized-animal-model-of-parkinsonism
#3
Elaheh Arbabi, Gholamali Hamidi, Sayyed Alireza Talaei, Mahmoud Salami
OBJECTIVES: Parkinson's disease (PD) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. Evidence indicates that PD occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. It is reported that soy genistein, an estrogen agonist phytoestrogen, display neuroprotective effects against neuronal death. In this study we evaluated the effect of genistein in animal models of Parkinsonism (P) and Parkinsonism + ovariectomized (OP)...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28091829/inhibition-of-dpp-4-activity-and-neuronal-atrophy-with-genistein-attenuates-neurological-deficits-induced-by-transient-global-cerebral-ischemia-and-reperfusion-in-streptozotocin-induced-diabetic-mice
#4
Mithun Singh Rajput, Purnima Dey Sarkar, Nilesh Prakash Nirmal
Genistein, an isoflavonoid phytoestrogen, has been known for its potential pharmacological properties especially for neuroprotection and treating diabetes. The present study aims to determine the neuroprotective efficacy of genistein against global cerebral ischemia-reperfusion-induced neuronal injury in streptozotocin-induced diabetic mice and explore the underlying mechanisms. Streptozotocin-induced diabetic mice were subjected to transient cerebral ischemia by occluding both common carotid arteries for 30 min followed by 24 h reperfusion to induce neuronal injury...
January 16, 2017: Inflammation
https://www.readbyqxmd.com/read/28072464/genistein-and-tyrphostin-ag556-decrease-human-atrial-ultra-rapidly-activating-delayed-rectifier-potassium-current-by-inhibiting-egfr-tyrosine-kinase
#5
Guo-Sheng Xiao, Yan-Hui Zhang, Wei Wu, Hai-Ying Sun, Yan Wang, Gui-Rong Li
BACKGROUND AND PURPOSE: The ultra-rapidly activating delayed rectifier K(+) current IKur (encoded by Kv1.5 or KCNA5) plays an important role in human atrial repolarization. The present study investigates the regulation of this current by protein tyrosine kinases (PTKs). EXPERIMENTAL APPROACH: Whole-cell patch voltage-clamp technique, and immunoprecipitation/western blotting analysis were used to investigate whether the PTK inhibitors genistein, Tyrphostin AG556 (AG556) and PP2 regulate human atrial IKur , and hKv1...
January 10, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28066099/genistein-synergizes-centchroman-action-in-human-breast-cancer-cells
#6
Shweta Kaushik, Hari Shyam, Ramesh Sharma, Anil K Balapure
OBJECTIVES: Despite the progress in the diagnosis and treatment of breast cancer, it remains a major health problem in women. Natural flavones along with chemotherapeutic agents enhance therapeutic response and minimize toxicity of chemical agents. Centchroman (CC) colloquially called as ormeloxifene, is a nonsteroidal oral contraceptive categorized as selective estrogen receptor modulator with anti-breast cancer activity. Genistein (GN), an isoflavone found mainly in soy products possesses anti-cancerous potential against a number of cancers including breast...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28063855/low-dietary-soy-isoflavonoids-increase-hippocampal-spine-synapse-density-in-ovariectomized-rats
#7
Neil J MacLusky, Gladis Thomas, Csaba Leranth
High dietary intake of plant estrogens (phytoestrogens) can affect brain structure and function. The effects of phytoestrogen intake within the range of normal animal and human dietary consumption, however, remain uncertain. The aim of the present study was to determine the effects of the isoflavonoids present in a standard low phytoestrogen laboratory rat chow on spine synapse density in the stratum radiatum of area CA1 of the hippocampus. Weanling rats (22 days old) were fed either standard chow (Teklad 2018), a nutritionally comparable diet without soy (Teklad 2016) or a custom diet containing Teklad 2016 supplemented with the principal soy isoflavonoids, daidzein and genistein, for 40 days...
January 4, 2017: Brain Research
https://www.readbyqxmd.com/read/28054996/production-and-anti-melanoma-activity-of-methoxyisoflavones-from-the-biotransformation-of-genistein-by-two-recombinant-escherichia-coli-strains
#8
Chien-Min Chiang, Yu-Jhe Chang, Jiumn-Yih Wu, Te-Sheng Chang
Biotransformation of the soy isoflavone genistein by sequential 3'-hydroxylation using recombinant Escherichia coli expressing tyrosinase from Bacillus megaterium and then methylation using another recombinant E. coli expressing O-methyltransferase from Streptomyces peucetius was conducted. The results showed that two metabolites were produced from the biotransformation, identified as 5,7,4'-trihydroxy-3'-methoxyisoflavone and 5,7,3'-trihydroxy-4'-methoxyisoflavone, respectively, based on their mass and nuclear magnetic resonance spectral data...
January 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28054950/microbial-glycosylation-of-daidzein-genistein-and-biochanin-a-two-new-glucosides-of-biochanin-a
#9
Sandra Sordon, Jarosław Popłoński, Tomasz Tronina, Ewa Huszcza
Biotransformation of daidzein, genistein and biochanin A by three selected filamentous fungi was investigated. As a result of biotransformations, six glycosylation products were obtained. Fungus Beauveria bassiana converted all tested isoflavones to 4″-O-methyl-7-O-glucosyl derivatives, whereas Absidia coerulea and Absidia glauca were able to transform genistein and biochanin A to genistin and sissotrin, respectively. In the culture of Absidia coerulea, in addition to the sissotrin, the product of glucosylation at position 5 was formed...
January 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28041561/changes-in-equol-and-major-soybean-isoflavone-contents-during-processing-and-storage-of-yogurts-made-from-control-or-isoflavone-enriched-bovine-milk-determined-using-lc-ms-tof-analysis
#10
Jitka Kašparovská, Kateřina Dadáková, Jan Lochman, Sylvie Hadrová, Ludmila Křížová, Tomáš Kašparovský
The effect of supplementing a basal diet for dairy cows with "Soybean extract 40" (Biomedica, Prague, Czech Republic), containing 40% soybean isoflavones, on the contents of daidzein, glycitein, genistein, and equol in milk as well as fresh and mature yogurts was estimated. To determine the contents of these isoflavonoids, an efficient analytical LC-MS (TOF) technique was used. The "Soybean extract 40" used in our study contained an especially high proportion of daidzein (307gkg(-1)). In both milk and yogurt samples, the amounts of daidzein and its metabolite equol were significantly higher in samples obtained from cows that received the isoflavone extract-supplemented diet than from those that received the basal diet, as the precursor daidzein contributed to the increased equol concentrations...
May 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28033065/effects-of-bioactive-compounds-on-odontogenic-differentiation-and-mineralization
#11
S Phung, C Lee, C Hong, M Song, J K Yi, R G Stevenson, M K Kang, K-H Shin, N-H Park, R H Kim
Direct pulp capping involves the placement of dental materials directly onto vital pulp tissues after deep caries removal to stimulate the regeneration of reparative dentin. This physical barrier will serve as a "biological seal" between these materials and the pulp tissue. Although numerous direct pulp capping materials are available, the use of small bioactive compounds that can potently stimulate and expedite reparative dentin formation is still underexplored. Here, the authors compared and evaluated the pro-osteogenic and pro-odontogenic effects of 4 small bioactive compounds- phenamil (Phen), purmorphamine (Pur), genistein (Gen), and metformin (Met)...
January 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28031375/urinary-phytoestrogen-concentrations-are-not-associated-with-incident-endometriosis-in-premenopausal-women
#12
Sunni L Mumford, Jennifer Weck, Kurunthachalam Kannan, Germaine M Buck Louis
BACKGROUND: Phytoestrogens have been associated with subtle hormonal changes, but their effects on endometriosis are largely unknown. OBJECTIVE: We assessed the association between urinary concentrations of phytoestrogens and incident endometriosis. METHODS: We included an operative sample of 495 premenopausal women aged 18-44 y undergoing laparoscopies and laparotomies at 14 clinical sites between 2007 and 2009 and a general population sample of 131 women from the same geographic area who were matched on age and menstruation status...
December 28, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/28013556/%C3%AE-glucosidase-inhibitors-and-phytotoxins-from-streptomyces-xanthophaeus
#13
Jing Wei, Xiu-Yun Zhang, Shan Deng, Lin Cao, Quan-Hong Xue, Jin-Ming Gao
Twenty-four metabolites 1-24 were isolated from the fermentation broth of Streptomyces xanthophaeus. Their structures were elucidated on the basis of spectroscopic analysis and by comparison of their NMR data with literature data reported. Daidzein (1), genistein (2) and gliricidin (3) inhibited α-glucosidase in vitro with IC50 values of 174.2, 36.1 and 47.4 μM, respectively, more potent than the positive control, acarbose. Docking study revealed that the amino acid residue Thr 215 is the essential binding site for active ligands 2...
December 26, 2016: Natural Product Research
https://www.readbyqxmd.com/read/28003845/all-trans-retinoic-acid-and-genistein-induce-cell-apoptosis-in-ovcar-3-cells-by-increasing-the-p14-tumor-suppressor-gene
#14
Mehdi Nikbakht Dastjerdi, Saeed Zamani, Mohammad Mardani, Batool Hashemi Beni
In this study, we evaluated the effects of all-trans retinoic acid (ATRA) alone or in combination with genistein (GEN) in p14 tumor suppressor gene and subsequent apoptosis of human ovarian carcinoma cells (OVCAR-3). The cells were treated with ATRA or GEN at concentrations of 50 and 25 μM respectively, either alone or in combination for 24 and 48 h. The cell viability was evaluated using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay. The percentage of cell apoptosis was determined using flow cytometry and p14 gene expression was measured using real time PCR...
December 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27990149/genistein-a-novel-anthocyanin-synthesis-promoter-that-directly-regulates-biosynthetic-genes-in-red-cabbage-in-a-light-dependent-way
#15
Na Zhang, Yan Qi, Hai-Jun Zhang, Xiaoyun Wang, Hongfei Li, Yantong Shi, Yang-Dong Guo
Genistein (GNT), an isoflavone, is used in the clinical treatment of various health disorders. GNT is found in primary food source plants and some medical plants. However, studies on the functions of GNT in plants are rarely reported. In this study, we demonstrated that GNT plays an important role in promoting anthocyanin accumulation in red cabbage. GNT solutions (10, 20, 30, 40, and 50 mg/L) as foliar fertilizers were applied to red cabbage. Consequently, anthocyanin accumulation in red cabbage increased in a light-dependent manner...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27989781/the-present-and-future-of-human-sexuality-impact-of-faulty-perinatal-hormonal-imprinting
#16
REVIEW
György Csaba
INTRODUCTION: Hormonal imprinting occurs perinatally, when the developing hormone receptors connect to their target hormones. This is required for the normal development of the receptor-hormone connection. At this time, the selectivity of receptors is weak and can be misdirected to related endogenous or exogenous molecules, such as other members of the same hormone family, synthetic hormones, drugs, hormone-like environmental pollutants, and endocrine disruptors. In this situation, faulty hormonal imprinting develops with lifelong consequences, which are manifested by altered receptor binding capacity, hormone production, changed bone formation, and brain neurotransmitter content...
December 15, 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27988307/interleukin-6-and-neuregulin-1-as-regulators-of-utrophin-expression-via-the-activation-of-nrg-1-erbb-signaling-pathway-in-mdx-cells
#17
Nevenka Juretić, Josefina Díaz, Felipe Romero, Gustavo González, Enrique Jaimovich, Nora Riveros
Duchenne muscular dystrophy (DMD) is a neuromuscular disease originated by mutations in the dystrophin gene. A promising therapeutic approach deals with functional substitution of dystrophin by utrophin, a structural homolog that might be able to compensate dystrophin absence in DMD muscle fibers. It has been described that both interleukin-6 (IL-6) and neuregulin-1 (NRG-1; Heregulin-HRG) induce utrophin expression in skeletal muscle. We investigated a possible functional link among IL-6, NRG-1 and utrophin, in normal (C57) and dystrophic (mdx) skeletal muscle cells...
December 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27986590/phytosteroids-beyond-estrogens-regulators-of-reproductive-and-endocrine-function-in-natural-products
#18
REVIEW
Matthew Dean, Brian T Murphy, Joanna E Burdette
Foods and botanical supplements can interfere with the endocrine system through the presence of phytosteroids - chemicals that interact with steroids receptors. Phytoestrogens are well studied, but compounds such as kaempferol, apigenin, genistein, ginsenoside Rf, and glycyrrhetinic acid have been shown to interact with non-estrogen nuclear receptors. These compounds can have agonist, antagonist, or mixed agonist/antagonist activity depending on compound, receptor, cell line or tissue, and concentration. Some phytosteroids have also been shown to inhibit steroid metabolizing enzymes, resulting in biological effects through altered endogenous steroid concentrations...
December 13, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27986565/inhibition-of-protein-tyrosine-phosphatases-unmasks-vasoconstriction-and-potentiates-calcium-signaling-in-rat-aorta-smooth-muscle-cells-in-response-to-an-agonist-of-5-ht2b-receptors-bw723c86
#19
Galina Y Mironova, Piotr P Avdonin, Nikolay V Goncharov, Richard O Jenkins, Pavel V Avdonin
In blood vessels, serotonin 5-HT2B receptors mainly mediate relaxation, although their activation by the selective agonist BW723C86 is known to exert contraction of aorta in deoxycorticosterone acetate (DOCA)-salt and N(omega)-nitro-l-arginine (l-NAME) hypertensive rats [Russel et al., 2002; Banes et al., 2003] and in mice with type 2 diabetes [Nelson et al., 2012]. The unmasking effect on vasoconstriction can be caused by a shift in the balance of tyrosine phosphorylation in smooth muscle cells (SMC) due to oxidative stress induced inhibition of protein tyrosine phosphatases (PTP)...
December 13, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27981593/determination-of-isoflavone-genistein-and-daidzein-concentration-of-soybean-seed-as-affected-by-environment-and-management-inputs
#20
Randy Laurenz, Pavani Tumbalam, Seth Naeve, Kurt D Thelen
BACKGROUND: Isoflavones, such as genistein and daidzein, are produced in soybean seed (Glycine max (L.) Merr.) and may be associated with health benefits in the human diet. More research is required to determine the effect of agronomic soybean treatments on isoflavone concentration. In this study from 2012 to 2014 at Michigan State University and Breckenridge locations, we have have evaluated agronomic input management systems which are marketed to increase or protect potential soybean grain yield, including: nitrogen fertilization; herbicide-defoliant; foliar applied fertilizer; a biological-based foliar application; foliar applied fungicide; foliar applied insecticide; a seed applied fungicide; and a maximized seed treatment that included fungicide and insecticide as well as an inoculant and lipo-chitooligosaccharide nodulation promoter; for their effect on soybean seed genistein and daidzein concentrations...
December 16, 2016: Journal of the Science of Food and Agriculture
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