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https://www.readbyqxmd.com/read/28445052/facile-preparation-of-drug-loaded-tristearin-encapsulated-superparamagnetic-iron-oxide-nanoparticles-using-coaxial-electrospray-processing
#1
Manoochehr Rasekh, Zeeshan Ahmad, Richard Barrie Michael Cross, Javier Hernández Gil, James D E T Wilton-Ely, Philip W Miller
Naturally occurring polymers are promising biocompatible materials that have many applications for emerging therapies, drug delivery systems and diagnostic agents. The handling and processing of such materials still constitutes a major challenge which can limit the full exploitation of their properties. This study explores an ambient environment processing technique: coaxial electrospray (CO-ES) to encapsulate genistein (an isoflavonoid and model drug), superparamagnetic iron oxide nanoparticles (SPIONs, 10-15 nm) and a fluorophore (BODIPY) into a layered (triglyceride tristearin shell) particulate system, with a view to constructing a theranostic agent...
April 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28439683/genistein-modulation-of-seizure-involvement-of-estrogen-and-serotonin-receptors
#2
Saeed Amiri Gheshlaghi, Razieh Mohammad Jafari, Mohammad Algazo, Nastaran Rahimi, Hussein Alshaib, Ahmad Reza Dehpour
Genistein, a major source of phytoestrogen exposure for humans and animals, has been shown to mediate neuroprotection in Alzheimer's disease and status epilepticus. In the present study, we investigated the effect of genistein on pentylenetetrazole-induced seizures in ovariectomized mice and the possible involvement of estrogenic and serotonergic pathways in the probable effects of genistein. Intraperitoneal (i.p.) administration of genistein (10 mg/kg) significantly increased the seizure threshold 30 min prior to induction of seizures 14 days after ovariectomy surgery...
April 24, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28429578/soy-isoflavones-enhance-%C3%AE-defensin-synthesis-and-secretion-in-endometrial-epithelial-cells-with-exposure-to-tlr3-agonist-polyinosinic-polycytidylic-acid
#3
Yotesawee Srisomboon, Sutthasinee Poonyachoti, Chatsri Deachapunya
PROBLEM: β-defensins are important innate chemical barriers that protect the endometrium from pathogen invasion. The effects of soy isoflavones, genistein and daidzein, on the expression and secretion of porcine β-defensins (PBD) in endometrial epithelial cells were investigated under normal or poly I:C-stimulated conditions. METHOD OF STUDY: Primary cultured porcine endometrial epithelial (PE) cells were pretreated with genistein or daidzein followed by poly I:C inoculation...
April 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28427003/ce-method-for-the-in-process-control-of-the-synthesis-of-active-substances-conjugated-with-gold-nanoparticles
#4
Wioleta Maruszak, Elżbieta U Stolarczyk, Krzysztof Stolarczyk
A fast capillary electrophoresis method was developed and validated for the in-process control (IPC) of the synthesis of active substances (APIs) with gold nanoparticles (AuNPs). The capillary electrophoresis method was key to ensure that the reaction step conducted in order to obtain AuNP and API conjugates will produce the expected product without the presence of free APIs, which is a critical parameter determining the quality of the synthetic material. Capillary electrophoresis was performed using uncoated fused-silica capillaries with the effective length of 40cm, 50μm i...
April 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28425936/genistein-ameliorates-ischemia-reperfusion-induced-renal-injury-in-a-sirt1-dependent-manner
#5
Wei-Fang Li, Kang Yang, Ping Zhu, Hong-Qian Zhao, Yin-Hong Song, Kuan-Can Liu, Wei-Feng Huang
Renal ischemia/reperfusion (I/R) injury continues to be a complicated situation in clinical practice. Genistein, the main isoflavone found in soy products, is known to possess a wide spectrum of biochemical and pharmacological activities. However, the protective effect of genistein on renal I/R injury has not been well investigated. In the current study, we explore whether genistein exhibits its renal-protective effects through SIRT1 (Sirtuin 1) in I/R-induced mice model. We found the treatment of genistein significantly reduced renal I/R-induced cell death, simultaneously stimulating renal cell proliferation...
April 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28423510/genistein-inhibits-the-growth-and-regulates-the-migration-and-invasion-abilities-of-melanoma-cells-via-the-fak-paxillin-and-mapk-pathways
#6
Shuna Cui, Juan Wang, Qingqing Wu, Jing Qian, Changshui Yang, Ping Bo
Genistein is one of the main components of soy-based foods, which are widely known for their many benefits, including anti-cancer, anti-inflammatory, and antioxidant effects. In this study, we investigated the anti-metastasis effects of genistein on B16F10 melanoma cells. Our results showed that genistein strongly inhibited B16F10 cell proliferation and induced apoptosis in time- and concentration-dependent manners. Genistein altered the morphology of B16F10 cells to an elongated shape with slim pseudopodia-like protrusions...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412308/genistein-prevention-of-hyperglycemia-and-improvement-of-glucose-tolerance-in-adult-non-obese-diabetic-mice-are-associated-with-alterations-of-gut-microbiome-and-immune-homeostasis
#7
Guannan Huang, Joella Xu, Daniel E Lefever, Travis C Glenn, Tamas Nagy, Tai L Guo
Although studies have linked soy phytoestrogen 4,7,4-trihydroxyisoflavone genistein (GEN) to reduced type 1 diabetes (T1D) risk, the mechanism of dietary GEN on T1D remains unknown. In our studies, adult non-obese diabetic (NOD) mouse model was employed to investigate the effects of GEN exposure on blood glucose level (BGL), glucose tolerance, gut microbiome, and immune responses. Adult male and female NOD mice were fed with either soy-based or casein-based diet, and received GEN at 20mg/kg body weight by gavage daily...
April 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28396216/assessment-of-the-potential-activity-of-major-dietary-compounds-as-selective-estrogen-receptor-modulators-in-two-distinct-cell-models-for-proliferation-and-differentiation
#8
Sylvain Lecomte, Marie Lelong, Gaëlle Bourgine, Theo Efstathiou, Christian Saligaut, Farzad Pakdel
Estrogen receptors (ERs) α and β are distributed in most tissues of women and men. ERs are bound by estradiol (E2), a natural hormone, and mediate the pleiotropic and tissue-specific effects of E2, such as proliferation of breast epithelial cells or protection and differentiation of neuronal cells. Numerous environmental molecules, called endocrine disrupting compounds, also interact with ERs. Phytoestrogens belong to this large family and are considered potent therapeutic molecules that act through their selective estrogen receptor modulator (SERM) activity...
April 7, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28396211/cold-tolerance-of-the-asian-tiger-mosquito-aedes-albopictus-and-its-response-to-epigenetic-alterations
#9
Aljoscha Kreß, Ann-Marie Oppold, Ulrich Kuch, Jörg Oehlmann, Ruth Müller
Phenotypic plasticity is considered as one of the key traits responsible for the establishment of populations of the invasive mosquito Aedes albopictus, an important vector of viral and parasitic pathogens. The successful spread of this species to higher altitudes and latitudes may be explained by its ability to rapidly induce a heritable low-temperature phenotype (cold hardiness in eggs). As a result of the low genetic diversity of founder populations, an epigenetic short-term mechanism has been suggested as the driver of this diversification...
April 7, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28393079/tyrosine-phosphorylation-of-nr2b-contributes-to-chronic-migraines-via-increased-expression-of-cgrp-in-rats
#10
Xiping Liang, Sha Wang, Guangcheng Qin, Jingmei Xie, Ge Tan, Jiying Zhou, Devin W McBride, Lixue Chen
Tyrosine phosphorylation of NR2B (NR2B-pTyr), a subunit of the N-methyl-D-aspartate (NMDA) receptor, has been reported to develop central sensitization and persistent pain in the spine, but its effect in chronic migraines has not been examined. We hypothesized that tyrosine phosphorylation of NR2B contributes to chronic migraines (CM) through calcitonin gene-related peptide (CGRP) in rats. Ninety-four male Sprague-Dawley rats were subjected to seven inflammatory soup (IS) injections. In a subset of animals, the time course and location of NR2B tyrosine phosphorylation were detected by western blot and immunofluorescence double staining...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28391863/evaluation-of-new-natural-deep-eutectic-solvents-for-the-extraction-of-isoflavones-from-soy-products
#11
Sylwia Bajkacz, Jakub Adamek
Natural deep eutectic solvents (NADESs) are considered to be new, safe solvents in green chemistry that can be widely used in many chemical processes such as extraction or synthesis. In this study, a simple extraction method based on NADES was used for the isolation of isoflavones (daidzin, genistin, genistein, daidzein) from soy products. Seventeen different NADES systems each including two or three components were tested. Multivariate data analysis revealed that NADES based on a 30% solution of choline chloride: citric acid (molar ratio of 1:1) are the most effective systems for the extraction of isoflavones from soy products...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28391283/mothers-consumption-of-soy-drink-but-not-black-tea-increases-the-flavonoid-content-of-term-breast-milk-a-pilot-randomized-controlled-intervention-study
#12
Frank Jochum, Birgit Alteheld, Pamela Meinardus, Norbert Dahlinger, Antonia Nomayo, Peter Stehle
OBJECTIVE: We performed a pilot RCT to prove the hypothesis that a controlled ingestion of polyphenol-rich beverages (soy drink, decaffeinated black tea) in nutritive dosages by nursing women has an effect on the composition (flavonoid concentration, total antioxidant capacity) of breast milk. METHODS: Healthy nursing women were supplemented with either 250 mL of a soy drink (12 mg isoflavones; n = 18), 300 mL decaffeinated black tea (67 mg catechins; n = 18), or 300 mL water (n = 8, control) for 6 days...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28373425/me-143-is-superior-to-genistein-in-suppression-of-wnt-signaling-in-colon-cancer-cells
#13
COMPARATIVE STUDY
Sofya Pintova, Kestutis Planutis, Marina Planutiene, Randall F Holcombe
BACKGROUND: This study tested the effect of the soy isoflavones genistein and ME-143, and two chemotherapeutic agents, 5-fluorouracil (5FU) and oxaliplatin, on WNT signaling. MATERIALS AND METHODS: Colon cancer cell lines RKO (hereditary nonpolyposis colorectal cancer type) and DLD1 (most common colorectal cancer type driven by a mutation in WNT pathway) were utilized. WNT throughput was measured using a β-catenin-responsive SuperTopFlash luciferase assay. A stabilized β-catenin construct was employed to test β-catenin involvement in the mechanism of drug activity...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28370072/expression-profiling-of-sudanese-visceral-leishmaniasis-patients-pre-and-post-treatment-with-sodium-stibogluconate
#14
Mohamed A M Salih, Michaela Fakiola, Paul A Lyons, Brima M Younis, Ahmed M Musa, Ahmed M Elhassan, Denise Anderson, Genevieve Syn, Muntaser E Ibrahim, Jenefer M Blackwell, Hiba S Mohamed
Visceral leishmaniasis (VL) in Sudan caused by Leishmania donovani is fatal in susceptible individuals if untreated. Treatment with Sodium Stibogluconate (SSG) leads to post kala azar dermal leishmaniasis (PKDL) in 58% of patients. Here Affymetrix microarrays were used to identify genes differentially expressed in lymph nodes (N=9 paired samples) pre- and post-treatment with SSG. Using the Bioconductor package limma, 438 genes from 28,869 post quality-control probe-sets were differentially expressed (Pnominal ≤0...
March 31, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28363543/submicrometric-hypromellose-acetate-succinate-particles-as-carrier-for-soy-isoflavones-extract-with-improved-skin-penetration-performance
#15
Pasquale Del Gaudio, Paola Russo, Rosalia Rodriguez Dorado, Francesca Sansone, Teresa Mencherini, Franco Gasparri, Rita Patrizia Aquino
In this study, hypromellose acetate succinate (HPMCAS) stable submicronic particles loaded with a soy isoflavones extract have been obtained by nano spray drying technology. HPMCAS has been used as excipient able to increase both stability and supersaturation levels of the active ingredients hence able to enhance skin penetration performance of genistein and daidzein. The influence of polymer/extract ratio as other process variables, on particle size, morphology and permeation performance, have been investigated...
June 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28363417/multiresidue-determination-of-estrogens-in-different-dairy-products-by-ultra-high-performance-liquid-chromatography-triple-quadrupole-mass-spectrometry
#16
Bárbara Socas-Rodríguez, Antonio V Herrera-Herrera, Javier Hernández-Borges, Miguel Ángel Rodríguez-Delgado
In this work, a simple and fast methodology has been validated and applied for the analysis of a group of 22 estrogenic compounds including eight phytoestrogens (i.e. daidzein, enterodiol, glycitein, enterolactone, genistein, formononetin, prunetin, biochanin A), six mycotoxins (β-zearalanol, β-zearalenol, α-zearalanol, α-zearalenol, zearalanone, zearalenone) as well as four synthetic (i.e. ethynylestradiol, diethylstilbestrol, dienestrol, hexestrol) and four natural estrogens (i.e. estriol, 17β-estradiol, 17α-estradiol, estrone) in different dairy products...
March 19, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28357646/the-usefulness-of-non-toxic-plant-metabolites-in-the-control-of-bacterial-proliferation
#17
Sergio Gutiérrez, Alfredo Morán, Honorina Martínez-Blanco, Miguel A Ferrero, Leandro B Rodríguez-Aparicio
The effect of generally recognised as safe (GRAS) plant metabolites in regulating the growth of human pathogenic and probiotic bacteria and in the formation of biofilm was investigated. Thymol, carvacrol and eugenol showed the strongest antibacterial action against both pathogenic and probiotic microorganisms, at a subinhibitory concentration (SIC) of ≤50 μg ml(-1). Genistein, hydroquinone, p-hydroxybenzoic acid and resveratrol also showed antibacterial effects but at a wide concentration range (SIC = 50-1000 μg ml(-1))...
March 29, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28346099/development-of-novel-cell-lines-for-high-throughput-screening-to-detect-estrogen-related-receptor-alpha-modulators
#18
Christina T Teng, Jui-Hua Hsieh, Jinghua Zhao, Ruili Huang, Menghang Xia, Negin Martin, Xiaohua Gao, Darlene Dixon, Scott S Auerbach, Kristine L Witt, B Alex Merrick
Estrogen-related receptor alpha (ERRα), the first orphan nuclear receptor discovered, is crucial for the control of cellular energy metabolism. ERRα and its coactivator, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), are required for rapid energy production in response to environmental challenges. They have been implicated in the etiology of metabolic disorders such as type 2 diabetes and metabolic syndrome. ERRα also plays a role in the pathogenesis of breast cancer. Identification of compounds that modulate ERRα signaling may elucidate environmental factors associated with these diseases...
January 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28339658/acute-cell-volume-regulation-by-janus-kinase-2-mediated-sodium-hydrogen-exchange-activation-develops-at-the-late-one-cell-stage-in-mouse-preimplantation-embryos
#19
Baozeng Xu, Chenxi Zhou, Megan Meredith, Jay M Baltz
Early preimplantation embryos are extremely sensitive to dysregulation of cell volume, which can lead to developmental arrest. It was previously shown that mouse embryos at the two-cell stage respond to a cell volume decrease by quickly activating Na+/H+ exchange via a signaling mechanism that involves the tyrosine kinase Janus kinase 2 (JAK2). However, it was not known whether this mechanism is active at the one-cell stage, when embryos are most sensitive to perturbed cell volume. Na+/H+ exchanger activity elicited by an induced cell volume decrease was significantly lower at the mid one-cell stage than at the late one-cell stage or during the two-cell stage...
March 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28336316/effects-of-age-and-soybean-isoflavones-on-hepatic-cholesterol-metabolism-and-thyroid-hormone-availability-in-acyclic-female-rats
#20
Branka Šošić-Jurjević, Dieter Lütjohann, Ivana Jarić, Marko Miler, Danijela Vojnović Milutinović, Branko Filipović, Vladimir Ajdžanović, Kostja Renko, Eva Katrin Wirth, Snežana Janković, Josef Kӧhrle, Verica Milošević
Soy-food and its isoflavones, genistein (G) and daidzein (D), were reported to exert mild cholesterol-lowering effect, but the underlying mechanism is still unclear. In this research, first we studied age-related alterations in hepatic cholesterol metabolism of acyclic middle-aged (MA) female rats. Then we tested if purified isoflavones may prevent or reverse these changes, and whether putative changes in hepatic thyroid hormone availability may be associated with this effect. Serum and hepatic total cholesterol (TChol), bile acid and cholesterol precursors, as well as serum TSH and T4 concentrations, hepatic deiodinase (Dio) 1 enzyme activity and MCT8 protein expression were determined by comparing data obtained for MA with young adult (YA) intact (IC) females...
June 2017: Experimental Gerontology
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