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https://www.readbyqxmd.com/read/29231720/phosphorylation-of-isoflavone-by-bacillus-subtilis-bcrc-80517-may-represent-xenobiotic-metabolism
#1
Chen Hsu, Bo-Yuan Wu, Yu-Chuan Chang, Chi-Fon Chang, Tai-Ying Chiou, Nan-Wei Su
Soy isoflavones, daidzein (DAI) and genistein (GEN), have beneficial effects on human health. However, their oral bioavailability is hampered by low aqueous solubility. Our previous study revealed two water-soluble phosphorylated isoflavones conjugates of isoflavones, daidzein 7-O-phosphate and genistein 7-O-phosphate, generated by biotransformation of Bacillus subtilis BCRC80517 cultivated with isoflavones. In this study, two novel derivatives of isoflavones, daidzein 4'-O-phosphate and genistein 4'-O-phosphate, were identified by HPLC-ESI-MS/MS and 1H, 13C and 31P NMR and the biotransformation road map was proposed...
December 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29226152/the-phytoestrogen-genistein-produces-similar-effects-as-17%C3%AE-estradiol-on-anxiety-like-behavior-in-rats-at-12-weeks-after-ovariectomy
#2
Juan Francisco Rodríguez-Landa, Jonathan Cueto-Escobedo, Abraham Puga-Olguín, Eduardo Rivadeneyra-Domínguez, Blandina Bernal-Morales, Emma Virginia Herrera-Huerta, Andrea Santos-Torres
The phytoestrogen genistein produces anxiolytic-like effects in ovariectomized rats, which highlights its potential therapeutic effect in ameliorating anxiety in surgical menopausal women. However, no studies have directly compared the effects of identical doses of genistein and 17β-estradiol, the main estrogen used in hormone replacement therapy in menopausal women. The present study evaluated the anxiolytic-like effects of identical doses of genistein and 17β-estradiol (0.045, 0.09, and 0.18 mg/kg/7 days, s...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29224366/biotransformation-of-soy-flour-isoflavones-by-aspergillus-niger-nrrl-3122-%C3%AE-glucosidase-enzyme
#3
Asmaa Abdella, Ashraf F El-Baz, Ibrahim A Ibrahim, Emad Eldin Mahrous, Shang-Tian Yang
β-glucosidase enzyme produced from Aspergillus niger NRRL 3122 has been partially purified and characterised. Its molecular weight was 180 KDa. The optimal pH and temperature were 3.98 and 55 °C, respectively. It promoted the hydrolysis of soy flour isoflavone glycosides to their aglycone. Two-level Plackett-Burman design was applied and effective variables for genistein production were determined. Reaction time had a significant positive effect, and pH had a significant negative effect. They were further evaluated using Box-Behnken model...
December 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29220536/cd36-deficiency-attenuates-immune-mediated-hepatitis-in-mice-by-modulating-the-proapoptotic-effects-of-cxcl10
#4
Che Xu, Chen Zhang, Jie Ji, Chao Wang, Jing Yang, Biao Geng, Ting Zhao, Hong Zhou, Xianmin Mu, Jinshun Pan, Shi Hu, Yuanfang Lv, Xingguo Chen, Hao Wen, Qiang You
The scavenger receptor, CD36, recognizes a diverse set of ligands, and has been implicated in a wide variety of normal and pathological processes, including lipid metabolism, angiogenesis, atherosclerosis, and phagocytosis. In particular, recent findings have demonstrated its crucial functions in sterile inflammation and tumor metastasis. However, the role of CD36 in immune-mediated hepatitis remains unclear. Concanavalin A (Con A)-induced liver injury is a well-established experimental T cell-mediated hepatitis...
December 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29217487/genistein-and-daidzein-treatments-differently-affect-uterine-homeostasis-in-the-ovary-intact-middle-aged-rats
#5
Ivana Jarić, Jasmina Živanović, Marko Miler, Vladimir Ajdžanović, Duško Blagojević, Nataša Ristić, Verica Milošević, Nataša Nestorović
This study aimed to investigate the effects of soy isoflavones, genistein (GEN) and daidzein, (DAI) on the uterine function in ovary-intact middle-aged rats. GEN and DAI (35mg/kg) were subcutaneously administrated to acyclic (12-month-old) Wistar females, daily, for 4weeks. Control group received either vehicle (olive oil and ethanol, 9:1) or remained intact. We found that GEN and DAI differently affect uterine morphophysiology. GEN significantly increased the uterine wet weight which was associated with hyperplastic changes, revealed by stereological and histomorphometrical analyses...
December 5, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29204990/apoptosis-induction-of-colorectal-cancer-cells-htl-9-in-vitro-by-the-transformed-products-of-soybean-isoflavones-by-ganoderma-lucidum
#6
Mei-Lin Cui, Huan-Yi Yang, Guo-Qing He
Soybean isoflavones have been one of the potential preventive candidates for antitumor research in recent years. In this paper, we first studied the transformation of soybean isoflavones with the homogenized slurry of Ganoderma lucidum. The resultant transformed products (TSI) contained (703.21±4.35) mg/g of genistein, with transformed rates of 96.63% and 87.82% of daidzein and genistein, respectively, and TSI also could enrich the bioactive metabolites of G. lucidum. The antitumor effects of TSI on human colorectal cancer cell line HTL-9, human breast cancer cell line MCF-7, and human immortalized gastric epithelial cell line GES-1 were also studied...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29202800/genistein-induces-apoptosis-of-colon-cancer-cells-by-reversal-of-epithelial-to-mesenchymal-via-a-notch1-nf-%C3%AE%C2%BAb-slug-e-cadherin-pathway
#7
Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi, Aike Li
BACKGROUND: Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS: To investigate the effects and mechanisms of genistein on EMT of colon cancer cells, HT-29 cells were used and treated by genistein and TNF-α in this paper. EMT was determined by cell invasion assays using a transwell chamber and the expression changes of EMT-related markers were confirmed by RT-PCR, Western blotting, and immunofluorescence staining...
December 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29200900/genistein-attenuates-isoflurane-induced-neurotoxicity-and-improves-impaired-spatial-learning-and-memory-by-regulating-camp-creb-and-bdnf-trkb-pi3k-akt-signaling
#8
Tao Jiang, Xiu-Qin Wang, Chuan Ding, Xue-Lian Du
Anesthetics are used extensively in surgeries and related procedures to prevent pain. However, there is some concern regarding neuronal degeneration and cognitive deficits arising from regular anesthetic exposure. Recent studies have indicated that brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are involved in learning and memory processes. Genistein, a plant-derived isoflavone, has been shown to exhibit neuroprotective effects. The present study was performed to examine the protective effect of genistein against isoflurane-induced neurotoxicity in rats...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29197967/effects-of-nutraceuticals-on-anaplastic-thyroid-cancer-cells
#9
Lorenzo Allegri, Francesca Rosignolo, Catia Mio, Sebastiano Filetti, Federica Baldan, Giuseppe Damante
PURPOSE: The anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a high mortality rate. Since nutraceuticals may exert beneficial effects on tumor biology, here, effects of four of these compounds [resveratrol, genistein, curcumin and epigallocatechin-3-gallate (EGCG)] on ATC cell lines were investigated. METHODS: Two ATC-derived cell lines were used: SW1736 and 8505C. Cell viability and in vitro aggressiveness was tested by MTT and soft agar assays...
December 2, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29189005/phytoestrogens-weaken-the-blood-milk-barrier-in-lactating-mammary-epithelial-cells-by-affecting-tight-junctions-and-cell-viability
#10
Yusaku Tsugami, Kota Matsunaga, Takahiro Suzuki, Nishimura Takanori, Ken Kobayashi
During lactation, mammary epithelial cells (MECs) form the blood-milk barrier by less-permeable tight junctions (TJs) to prevent leakage of milk components. Phytoestrogens affect proliferation, differentiation and apoptosis of MECs. However, it remains unclear whether phytoestrogens involve in the blood-milk barrier. Therefore, we investigated the influence of phytoestrogens (coumestrol, genistein, daidzein) by using in vitro mouse MEC culture model. The results showed that coumestrol or genistein changed the expression of TJ proteins (claudin-3, -4, occludin) and weakened the barrier function with reduction of β-casein production...
November 30, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29183775/novel-effects-of-phytoestrogenic-soy-isoflavones-on-serum-calcium-and-chloride-in-premenopausal-women-a-2-year-double-blind-randomized-placebo-controlled-study
#11
Lee-Jane W Lu, Nai-Wei Chen, Fatima Nayeem, V-M Sadagopa Ramanujam, Yong-Fang Kuo, Donald G Brunder, Manubai Nagamani, Karl E Anderson
BACKGROUND: Soy phytoestrogens are potential alternatives to postmenopausal hormone replacement therapy (HRT). Adverse effects of HRT such as myocardial infarction, stroke, and pulmonary embolism are mediated by calcium-induced signaling. OBJECTIVE: To determine whether soy isoflavones affect serum calcium in healthy female subjects. DESIGN: In a double-blind trial, 197 premenopausal women were randomly assigned to either isoflavone (N = 99) or placebo pills (N = 98) 5 days per week for up to 2 years, plus prenatal vitamins...
November 11, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29183770/nutraceuticals-an-emerging-therapeutic-approach-against-the-pathogenesis-of-alzheimer-s-disease
#12
REVIEW
Pritam Sadhukhan, Sukanya Saha, Sayanta Dutta, Sushweta Mahalanobish, Parames C Sil
Alzheimer's disease (AD) is regarded as a progressive and devastating neurodegenerative disorder. In aged individuals, it is the most prevalent cause of dementia and is characterized by gradual loss of cognitive functions. In the last decade, numerous research works were undertaken to investigate the pathogenesis of AD. Although the etiology of AD is still not clear, several histopathological studies confirm prominent changes in the AD affected brains. The major changes include the formation of senile plaques and neurofibrillary tangles primarily owing to the deposition of amyloid β plaques (Aβ) and hyper-phosphorylation of tau protein...
November 25, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29183043/benzo-e-pyrene-inhibits-endothelium-dependent-no-mediated-dilation-of-retinal-arterioles-via-superoxide-production-and-endoplasmic-reticulum-stress
#13
Takayuki Kamiya, Taiji Nagaoka, Tsuneaki Omae, Shinji Ono, Shinichi Otani, Akitoshi Yoshida
Purpose: To investigate whether benzo(e)pyrene (B(e)P), a toxicant in cigarette smoke, affects the endothelium-dependent nitric oxide (NO)-induced vasodilation of the retinal arterioles, and whether oxidative stress, distinct protein kinase signaling pathways, and endoplasmic reticulum (ER) stress are associated with the B(e)P-induced effect on the retinal arterioles. Methods: In this in vitro study, porcine retinal arterioles were isolated, cannulated, and pressurized without flow...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29180873/in-vitro-study-on-anti-cancer-properties-of-genistein-in-tongue-cancer
#14
Fatima Ardito, Mario R Pellegrino, Donatella Perrone, Giuseppe Troiano, Armando Cocco, Lorenzo Lo Muzio
Purpose: Tongue cancer is an extremely aggressive disease and is characterized by a poor prognosis. It is a complex disease to treat and current therapies have produced mediocre results with many side effects. Some facts suggest that natural essences can support traditional cancer therapy by carrying out a synergistic function with chemotherapy. Therefore, we evaluated the antitumor effects of genistein on tongue carcinoma cells. Methods: Genistein 20, 50 and 100 µM were used for 24, 48 and 72 hours on 3 tongue carcinoma cell lines...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29179999/phytochemicals-as-inhibitors-of-nf-%C3%AE%C2%BAb-for-treatment-of-alzheimer-s-disease
#15
REVIEW
Ean-Jeong Seo, Nicolas Fischer, Thomas Efferth
Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology of this disease remains incompletely understood and safe and effective therapies are required. AD is highly correlated with neuroinflammation and oxidative stress in brain causing neuronal loss. Nuclear factor of activated B-cells (NF-κB) is involved in physiological inflammatory processes and thus representing a promising target for inflammation-based AD therapy. Phytochemicals are able to interfere with the NF-κB pathway...
November 24, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29171786/bidirectional-regulation-of-genistein-on-the-proliferation-and-differentiation-of-c2c12-myoblasts
#16
Mailin Gan, Dongli Yang, Yuan Fan, Jingjing Du, Linyuan Shen, Qiang Li, Yanzhi Jiang, Guoqing Tang, Mingzhou Li, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu
1. Genistein is a widely studied phytoestrogen. The effects of genistein on myoblasts were reported long ago, but the conclusions are controversial. In the current study, we evaluated the effects of different concentrations of genistein on C2C12 myoblasts. 2. Genistein treatment promoted myoblast proliferation in a dose-development manner in the 0-2 µM/L range, reaching its maximum effect at 2 µM/L. Proliferation then declined, and a concentration higher than 20 µM/L showed significant inhibition. Additionally, genistein treatment promoted myoblast differentiation at a dose of 10 µM/L...
November 24, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29171242/-absorption-and-transport-of-isoflavonoid-compounds-from-tongmai-formula-across-human-intestinal-epithelial-caco-2-cells-in-vitro
#17
Fu-Rong Wang, Xiu-Wei Yang
Tongmai formula (TMF) is a drug combination of three components including Puerariae Lobatae Radix [roots of Pueraria lobata], Salviae Miltiorrhizae Radix (roots of Salvia miltiorrhiza) and Chuanxiong Rhizoma (rhizomes of Ligusticum chuanxiong) in a weight ratio of 1∶1∶1. The absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro were studied in this paper. The assay isoflavonoid compounds include daidzein, formononetin, 5-hydroxylononin, ononin, daidzin, 3'-methoxypuerarin, genistin, puerarin, formononetin-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, formononetin-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, lanceolarin, kakkanin, daidzein-7,4'-di-O-β-D-glucopyranoside, mirificin, 3'-hydroxypuerarin, 3'-methoxydaidzin, formononetin-8-C-β-D-xylopyranosyl-(1→6)-O-β-D-glucopyranoside, genistein-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, genistein-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (ambocin), 3'-hydroxymirificin, 6″-O-β-D-xylosylpuerarin, biochanin A-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, 3'-methoxydaidzein-7,4'-di-O-β-D-glucopyranoside, daidzein-7-O-β-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside, and daidzein-7-O-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29169220/fermented-soymilk-alleviates-lipid-accumulation-by-inhibition-of-srebp-1-and-activation-of-nrf-2-in-the-hepatocellular-steatosis-model
#18
Sang Bong Ahn, Wen Hao Wu, Jong Hun Lee, Dae Won Jun, Jihyun Kim, Riji Kim, Tae-Bok Lee, Jin Hyun Jun
Ingredients of soy and fermented soy products have been widely utilized as food supplements for health-enhancing properties. The aim was to evaluate the effects of fermented soymilk (FSM) and soymilk (SM) on the free fatty acid-induced lipogenesis in the hepatocellular steatosis model. HepG2 cells were incubated with palmitic acid (PA) for 24 h to induce lipogenesis and accumulation of intracellular lipid contents. The PA treated cells were co-incubated with FSM, SM, genistein, and estrogen, respectively. Lipid accumulations in the PA-treated HpG2 cells were significantly decreased by co-incubation with FSM...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29168930/cyclodextrin-encapsulation-of-daidzein-and-genistein-by-grinding-implication-on-the-glycosaminoglycan-accumulation-in-mucopolysaccharidosys-type-ii-and-iii-fibroblasts
#19
Barbara Fumić, Jasna Jablan, Dominik Cinčić, Marijana Zovko Končić, Mario Jug
This work was aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidoes (MPS), type II and III. DAD or GEN encapsulation with either 2-hydroxypropyl-β-cyclodextrin or sulphobuthylether-β-cyclodextrin were achieved by neat grinding and characterised by thermal analysis, X-ray powder diffraction, scanning electron microscopy and solubility testing, confirming the complexes formation with increased solubility with respect to starting compounds...
November 23, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29167771/somatic-vegetative-symptoms-evolution-in-postmenopausal-women-treated-with-phytoestrogens-and-hormone-replacement-therapy
#20
Delia Mirela Ţiţ, Annamaria Pallag, Ciprian Iovan, Gheorghe Furău, Cristian Furău, Simona Bungău
Background: The purpose of this study was to compare the effects of the phytoestrogens in relieving and/or suppressing the specific somatic-vegetative symptoms of menopause with those of the hormone therapy, administered in small doses. Methods: The study was conducted in the County Clinical Emergency Hospital Oradea - Obstetric-Gynecological Ambulatory, and in private obstetrics-gynecology cabinets from Bihor County (NW Romania), from November 2011 to January 2014...
November 2017: Iranian Journal of Public Health
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