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https://www.readbyqxmd.com/read/28817364/association-between-dietary-phytoestrogens-intakes-and-prostate-cancer-risk-in-sicily
#1
Giorgio I Russo, Marina Di Mauro, Federica Regis, Giulio Reale, Daniele Campisi, Marina Marranzano, Arturo Lo Giudice, Tatiana Solinas, Massimo Madonia, Sebastiano Cimino, Giuseppe Morgia
OBJECTIVE: In this study we aimed to investigate the association between dietary phytoestrogen consumption and prostate cancer in a sample of southern Italian individuals. METHODS: A population-based case-control study on the association between prostate cancer and dietary factors was conducted from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy (Registration number: 41/2015). A total of 118 histopathological-verified prostate cancer (PCa) cases and a total of 222 controls were collected...
August 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28816409/genistein-represses-pepck-c-expression-in-an-insulin-independent-manner-in-hepg2-cells-and-in-alloxan-induced-diabetic-mice
#2
Barilin Dkhar, Kitboklang Khongsti, Daiahun Thabah, Donkupar Syiem, Kapaettu Satyamoorthy, Bidyadhar Das
Genistein has been reported to exert beneficial effects on type 2 diabetes mellitus (T2DM); however, the underlying molecular mechanisms involved therein have not been clearly elucidated. To address this question, the effect of the genistein on the expression of phosphoenolpyruvate carboxykinase (PEPCK), and glucose production in HepG2 cells and in alloxan-induced diabetic mice was investigated. HepG2 cells were exposed to diferrent concentration of genistein in presence or absence of modulators, and the expression of cytosolic PEPCK (PEPCK-C) and the signalling pathways was studied...
August 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28810652/expression-of-prostate-stem-cell-antigen-is-downregulated-during-flavonoid-induced-cytotoxicity-in-prostate-cancer-cells
#3
Qiang Zhang, Guangdong Cheng, Hongbin Qiu, Yuexin Wang, Jingtao Wang, Hui Xu, Tao Zhang, Lixin Liu, Ye Tao, Zhongjuan Ren
Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer cases and may be a potential therapeutic target in the treatment of prostate cancer. The present study evaluated the cytotoxicity of three flavonoids (genistein, luteolin and quercetin) towards DU145 prostate cancer cells, and investigated the effect of these flavonoids on PSCA expression. The results demonstrated that genistein, luteolin and quercetin inhibited the growth of DU145 cells in a dose-dependent manner (P<0.05) and induced morphological changes characteristic of apoptosis in DU145 cells...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810648/combination-of-alendronate-and-genistein-synergistically-suppresses-osteoclastic-differentiation-of-raw267-4-cells-in-vitro
#4
Masayoshi Yamaguchi, Robert M Levy
Bone is a dynamic tissue that undergoes constant remodeling, with removal by osteoclastic bone resorption and replacement via osteoblastic bone formation and mineralization. Deterioration of bone mass with aging leads to osteoporosis. Bisphosphonates are potent inhibitors of osteoclastic bone resorption. Genistein, an isoflavone, exerts a bone anabolic effect by suppressing osteoclastic bone resorption and stimulating osteoblastic bone formation. The present study was undertaken to investigate the anabolic effects of a combination of alendronate and genistein on osteoclastic differentiation...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808397/genistein-attenuated-gastric-injury-on-indomethacin-induced-gastropathy-in-rats
#5
Sarocha Vivatvakin, Duangporn Werawatganon, Kanjana Somanawat, Naruemon Klaikeaw, Prasong Siriviriyakul
OBJECTIVES: To investigates the mucoprotective effect of genistein on gastric injury in rats with indomethacin (IMN)-induced gastropathy. METHODS: Male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control; n = 6) was given distilled water (DW). Group 2 (IMN; n = 6) was given indomethacin (IMN) 150 mg/kg dissolved in 5% sodium bicarbonate (NaHCO3(-)) 1 mL/rat via intragastric tube at time 0 and 4 h. Group 3 (genistein; n = 6) was given genistein 100 mg/kg dissolved in 0...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28804612/effect-of-genistein-on-expression-of-pancreatic-sirt1-inflammatory-cytokines-and-histological-changes-in-ovariectomized-diabetic-rat
#6
Hadi Yousefi, Alireza Alihemmati, Pouran Karimi, Mohammad Reza Alipour, Parisa Habibi, Nasser Ahmadiasl
OBJECTIVES: Genistein is reported to have anti-diabetic and anti-inflammatory functions, in particular, direct effects on β-cell proliferation and insulin secretion. In this study, we investigated the anti-inflammatory effect of genistein on the pancreatic β-cells in ovariectomized diabetic rat. MATERIALS AND METHODS: Forty female rats were divided into four groups: sham, bilateral ovariectomy (OVX), OVX.D (OVX+diabetes) and OVX.D.G (OVX.D+genistein). After bilateral ovariectomy, rats in the diabetic groups were fed high-fat diet (HFD), ad libitum for 4 weeks, and then a low dose of streptozotocin (STZ) (30 mg/kg) injected intraperitoneally...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28782102/retraction-genistein-mediated-histone-acetylation-and-demethylation-activates-tumor-suppressor-genes-in-prostate-cancer-cells-by-nobuyuki-kikuno-hiroaki-shiina-shinji-urakami-ken-kawamoto-hiroshi-hirata-yuichiro-tanaka-shahana-majid-mikio-igawa-and-rajvir-dahiya
#7
(no author information available yet)
The above article, published online on 22 April 2008 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Prof. Peter Lichter, and John Wiley & Sons Ltd. The retraction has been agreed due to errors identified in Figs, 3, 4, and 5. The concerns about these figures cannot be resolved because the original data can no longer be retrieved. REFERENCE: Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y, Majid S, Igawa M and Dahiya R...
October 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28776680/genistein-exerts-potent-antitumour-effects-alongside-anaesthetic-propofol-by-suppressing-cell-proliferation-and-nuclear-factor-%C3%AE%C2%BAb-mediated-signalling-and-through-upregulating-microrna-218-expression-in-an-intracranial-rat-brain-tumour-model
#8
Yuzhen Zheng, Haigen Liu, Yu Liang
OBJECTIVE: This study was implemented to evaluate the effect of genistein and propofol on intracranial tumour model. METHODS: Male Fischer 344 rats were subjected to intracranial implantation of 9L gliosarcoma cells. Genistein (100 or 200 mg/kg b.wt) was administered orally regularly from 3rd day after implantation to 25th day. Propofol (20 mg/kg; i.p.) was administered once every 5 days till 25th day and was administered 2 h after genistein. KEY FINDINGS: Human gliosarcoma cells (U251) exposed to genistein (12...
August 4, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28775360/phenylalanine-ammonia-lyase2-1-contributes-to-the-soybean-response-towards-phytophthora-sojae-infection
#9
Chuanzhong Zhang, Xin Wang, Feng Zhang, Lidong Dong, Junjiang Wu, Qun Cheng, Dongyue Qi, Xiaofei Yan, Liangyu Jiang, Sujie Fan, Ninghui Li, Dongmei Li, Pengfei Xu, Shuzhen Zhang
Phytophthora root and stem rot of soybean [Glycine max (L.) Merr.] caused by Phytophthora sojae is a destructive disease worldwide. Phenylalanine ammonia-lyase (PAL) is one of the most extensively studied enzymes related to plant responses to biotic and abiotic stresses. However, the molecular mechanism of PAL in soybean in response to P. sojae is largely unclear. Here, we characterize a novel member of the soybean PAL gene family, GmPAL2.1, which is significantly induced by P. sojae. Overexpression and RNA interference analysis demonstrates that GmPAL2...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771341/soyasapogenol-b-and-genistein-attenuate-lipopolysaccharide-induced-memory-impairment-in-mice-by-the-modulation-of-nf-%C3%AE%C2%BAb-mediated-bdnf-expression
#10
Hae-Ji Lee, Su-Min Lim, Da-Bin Ko, Jin-Ju Jeong, Yun-Ha Hwang, Dong-Hyun Kim
Lactobacillus plantarum C29-fermented defatted soybean (FDS), which contains soyasaponins such as soyasaponin I (SI) and soyasapogenol B (SB) and isoflavones such as genistin (GE) and genistein (GT), attenuated memory impairment in mice. Moreover, in the preliminary study, FDS and its soyasaponins and isoflavones significantly inhibited NF-κB activation in LPS-stimulated microglial BV2 cells. Therefore, we examined the effects of FDS and its constituents SI, SB, GT, and GE on LPS-induced memory impairment in mice...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28766479/an-hplc-method-for-the-determination-of-isoflavones-and-the-evaluation-of-their-antioxidant-capacity-in-both-homogeneous-and-microheterogeneous-systems
#11
Guillermo Montero, Germán Günther, Karina Valdés, Francisco Arriagada, Javier Morales
In this work, we developed an HPLC method to simultaneously quantify and hence evaluate the stability, distribution, and antioxidant capacity of six isoflavones: genistein, genistin, daidzein, daidzin, glycitin, and biochanin A. Isoflavones have been described as having an important estrogenic activity to treat menopausal symptoms and can reduce postmenopausal bone loss and also participate in the prevention of cardiovascular diseases. These beneficial properties are believed derived from their capacity to act as free-radical scavengers...
August 2, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28763032/a-chip-for-estrogen-receptor-action-detection-of-biomarkers-released-by-mcf-7-cells-through-estrogenic-and-anti-estrogenic-effects
#12
Konstanze Gier, Claudia Preininger, Ursula Sauer
The fluorescence-based multi-analyte chip platform for the analysis of estrogenic and anti-estrogenic substances is a new in vitro tool for the high throughput screening of environmental samples. In contrast to existing tools, the chip investigates the complex action of xenoestrogens in a human cell model by characterizing protein expression. It allows for the quantification of 10 proteins secreted by MCF-7 cells, representing various biological and pathological endpoints of endocrine action and distinguishing between estrogen- and anti-estrogen-dependent secretion of proteins...
August 1, 2017: Sensors
https://www.readbyqxmd.com/read/28756197/%C3%AE-glucosidase-inhibitory-effect-of-potentilla-astracanica-and-some-isoflavones-inhibition-kinetics-and-mechanistic-insights-through-in-vitro-and-in-silico-studies
#13
Didem Şöhretoğlu, Suat Sari, Arzu Özel, Burak Barut
α-Glucosidase enzyme inhibitors are clinically used for the treatment of Type 2 diabetes mellitus. We tested α-glucosidase inhibitory effects of Potentilla astracanica Jacq. extracts (1, 2), two compounds isolated from these extracts, prunetin 5-O-β-glucopyranoside (3) and genistein 5-O-β-glucopyranoside (4), and their aglycon forms (5 and 6). All the tested materials possessed remarkable α-glucosidase inhibitor activity compared to the positive control, acarbose. Genistein (6) showed the highest activity with an IC50 value of 1...
July 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28752072/early-endocrine-disruptors-exposure-acts-on-3t3-l1-differentiation-and-endocrine-activity
#14
Sofiane Boudalia, Christine Belloir, Marie-Louise Miller, Marie-Chantal Canivenc-Lavier
Introduction: Data from last years suggested that early exposure to endocrine disruptors (EDs) can predispose newborns to endocrine dysfunction of adipocytes, obesity, and associated disorders. The implication of EDs at low doses on adipocyte development has been poorly investigated. For instance, vinclozolin (V) is a dicarboximide fungicide widely used in agriculture since the 90's, alone or in mixture with genistein (G), an isoflavonoid from Leguminosae. This study aims to identify the effect of vinclozolin alone or with genistein, on adipose tissue properties using cell culture...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28749560/arbuscular-mycorrhizal-fungi-alter-the-content-and-composition-of-secondary-metabolites-in-bituminaria-bituminosa-l
#15
Laura Pistelli, Virginia Ulivieri, Silvia Giovanelli, Luciano Avio, Manuela Giovannetti, Luisa Pistelli
Secondary metabolites may be affected by arbuscular mycorrhizal fungi (AMF), which are beneficial symbionts associated with the roots of most plant species. Bituminaria bituminosa (L.) C.H.Stirt is known as a source of several phytochemicals and therefore used in folk medicine as vulnerary, cicatrizing, disinfectant agent. Characteristic metabolites found in B. bituminosa are furanocoumarins and pterocarpans which are used in cosmetics and as chemotherapeutic agents. Here we address the question whether AMF inoculation may affect positively the synthesis of these phytochemicals...
July 27, 2017: Plant Biology
https://www.readbyqxmd.com/read/28748495/evidence-for-interactions-between-homocysteine-and-genistein-insights-into-stroke-risk-and-potential-treatment
#16
Zyta Banecka-Majkutewicz, Leszek Kadziński, Michał Grabowski, Sylwia Bloch, Rajmund Kaźmierkiewicz, Joanna Jakóbkiewicz-Banecka, Magdalena Gabig-Cimińska, Grzegorz Węgrzyn, Alicja Węgrzyn, Bogdan Banecki
Elevated plasma homocysteine (2-amino-4-sulfanylbutanoic acid) level is a risk factor for stroke. Moreover, it has been suggested that high levels of homocysteine in the acute phase of an ischemic stroke can predict mortality, especially in stroke patients with the large-vessel atherosclerosis subtype. In clinical studies, supplementation with genistein (5, 7-dihydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one) decreased plasma homocysteine levels considerably. Therefore, genistein could be considered as a potential drug for prevention and/or treatment of stroke...
July 26, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28745354/soybean-isoflavones-ameliorate-ischemic-cardiomyopathy-by-activating-nrf2-mediated-antioxidant-responses
#17
Yang Li, Haiyan Zhang
Ischemic cardiomyopathy (IC) is the major cause of heart failure. Conventional medicine has been proved ineffective with adverse effects. Soybean presents exciting adjunctive therapies and shows protective benefits for IC. However, the molecular mechanisms remain unclear. Isoflavones are the main bioactive components of soybean and may be protective against heart disease. Isoflavones were extracted by using an acidic-ethanol method and analyzed by HPLC. All patients with ischemic stroke were randomly and evenly assigned to two groups: the isoflavone group (80 mg day(-1), n = 100) and control group (80 mg day(-1) placebo, n = 100), and the whole period of the experiment was 24 weeks...
August 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28738692/flavonoid-profile-antioxidant-and-antiglycation-properties-of-retama-sphaerocarpa-fruits-extracts
#18
S Boussahel, F Cacciola, S Dahamna, L Mondello, A Saija, F Cimino, A Speciale, M Cristani
Retama sphaerocarpa occurs in the Mediterranean area of North-east Africa and in the Iberian Peninsula, and grows on a variety of soil types and climatic conditions. Used in Algerian folk medicine, it is a valuable species for revegetation and soil restoration. The aim of this study is to evaluate flavonoid composition and antioxidant and antiglycation properties of methanolic and aqueous extracts from R. sphaerocarpa fruits. HPLC-PDA/ESI-MS was used to identify/quantify flavonoid content. Antioxidant activity was evaluated by Folin-Ciocalteu, ORAC, FRAP, TEAC, and DPPH assays, and antiglycation capability by glucose/fructose-BSA assay...
July 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28734166/naturally-occurring-immunomodulators-with-antitumor-activity-an-insight-on-their-mechanisms-of-action
#19
REVIEW
Shimaa Ibrahim Abdelmonym Mohamed, Ibrahim Jantan, Md Areeful Haque
Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities...
July 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28734033/genistein-and-enterolactone-in-relation-to-ki-67-expression-and-her2-status-in-postmenopausal-breast-cancer-patients
#20
Stefanie Jaskulski, Audrey Y Jung, Anja Rudolph, Theron Johnson, Kathrin Thöne, Esther Herpel, Peter Sinn, Jenny Chang-Claude
SCOPE: Phytoestrogens (PE) may improve breast cancer prognosis by modifying tumor prognostic markers, such as cell proliferation marker Ki-67 and human epidermal growth factor receptor 2 (HER2). Epidemiological evidence linking lignans and isoflavones to Ki-67 and HER2 is limited. We examined associations between the major metabolites of lignans and isoflavones - enterolactone (ENL) and genistein (GEN) - respectively, and Ki-67 expression and HER2 in tumor tissue of breast cancer patients...
July 21, 2017: Molecular Nutrition & Food Research
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