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https://www.readbyqxmd.com/read/27908969/synthesis-and-evaluation-of-the-new-estrogen-receptor-%C3%AE-selective-radioligand-18f-fhnp-comparison-with-18f-fes
#1
Inês F Antunes, Aren van Waarde, Rudi A Dierckx, Elisabeth G E de Vries, Geke A P Hospers, Erik F de Vries
: Estrogen receptors (ER) are targets for endocrine treatment of estrogen-dependent cancers. The ER consists of 2 isoforms, ERα and ERβ, which have distinct biological functions. While activation of ERα stimulates cell proliferation and cell survival, ERβ promotes apoptosis. Positron emission tomography (PET) of ERα and ERβ levels could provide more insight in response to hormonal treatment. 16α-(18)F-Fluoro-17β-estradiol ((18)F-FES) is a PET tracer for ER with relative selectivity for ERα...
December 1, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27894668/txn1-ctsd-and-cdk4-are-key-proteins-of-combination-therapy-with-taurine-epigallocatechin-gallate-and-genistein-against-liver-fibrosis-in-rats
#2
Wen Cao, Yan Li, Min Li, Xuerong Zhang, Ming Liao
The anti-fibrotic mechanism of combination therapy with taurine, epigallocatechin gallate and genistein was studied from the perspective of serum proteomics in our previous work. In order to further investigate and systematically analyse other possible therapeutic mechanism of combination therapy against liver fibrosis, isobaric tags for relative and absolute quantification (iTRAQ) proteomic analysis was applied to study the protein profile changes in liver tissue of carbon tetrachloride-induced liver fibrosis rats after combination therapy...
November 25, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27891704/isoflavone-genistein-inhibits-estrogen-induced-chloride-and-bicarbonate-secretory-mechanisms-in-the-uterus-in-rats
#3
Asma Chinigarzadeh, Kamarulzaman Karim, Sekaran Muniandy, Naguib Salleh
We hypothesized that genistein could affect the chloride (Cl(-) ) and bicarbonate (HCO3(-) ) secretory mechanisms in uterus. Ovariectomized female rats were given estradiol or estradiol plus progesterone with 25, 50, or 100 mg/kg/day genistein. Following completion of the treatment, uterine fluid Cl(-) and HCO3(-) concentrations were determined by in vivo uterine perfusion. Uteri were subjected for molecular biological analysis (Western blot, qPCR, and immunohistochemistry) to detect levels of expression of Cystic Fibrosis transmembrane regulator (CFTR), Cl(-) /HCO3(-) exchanger (SLC26a6), Na(+) /HCO3(-) cotransporter (SLC4a4), and estrogen receptor (ER)-α and β...
November 28, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27884790/altered-spermatogenesis-steroidogenesis-and-suppressed-fertility-in-adult-male-rats-exposed-to-genistein-a-non-steroidal-phytoestrogen-during-embryonic-development
#4
R Meena, Ch Supriya, K Pratap Reddy, P Sreenivasula Reddy
This article focuses on the effects of prenatal exposure to genistein on the mother, her pregnancy and reproductive functions of the male progeny, since these issues have ethological relevance in both animals and humans. Pregnant Wistar rats received i.p. injections of genistein at a dose level of 2, 20 or 100 mg/kg body weight daily from 12(th) to 19(th) day of gestation. Male pups from control and genistein exposed animals were weaned and allowed to develop until 100 days of age; however, when they were 90 days old, twelve males from each group were cohabited with untreated 90-day old females for 8 days...
November 21, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27876602/genistein-attenuates-d-galn-induced-liver-fibrosis-chronic-liver-damage-in-rats-by-blocking-the-tgf-%C3%AE-smad-signaling-pathways
#5
Ajaz Ahmad Ganai, Mohammad Husain
BACKGROUND AND AIM: Genistein is a major isoflavonoid abundantly found in soy. Earlier genistein has been reported to possess protective effect against a multitude of disorders including cancer. Previously we demonstrated the protective effects of Genistein in d-Galactosamine (D-GalN) induced fulminant hepatic failure (FHF) in rats. In present study, we evaluated the hepatoprotective activity of Genistein in rat model of chronic liver damage and liver fibrosis. METHODS: Liver fibrosis was induced by intraperitoneal injection of D-GalN (250 mg/kg BW) twice a week for 12 weeks...
November 19, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27868125/coumestrol-modulates-akt-and-wnt-%C3%AE-catenin-signaling-during-the-attenuation-of-adipogenesis
#6
Young Jin Jang, Hyo Jeong Son, Jiyun Ahn, Chang Hwa Jung, Taeyoul Ha
Coumestrol is a natural phytochemical present in plants such as red clover and soy, and has been reported to stimulate the estrogen receptor as a major phytoestrogen. While the molecular mechanisms responsible for the anti-adipogenic effects of phytoestrogens such as genistein and daidzein have been previously investigated, the effects of coumestrol on adipogenesis remain to be elucidated. We observed that coumestrol dose-dependently attenuates MDI (mixture of 3-isobutyl-1-methylxanthine, dexamethasone, and insulin)-induced lipid accumulation, consistent with an earlier study, while significantly inhibiting MDI-induced adipogenesis in the first 48 hours of differentiation, a critical time window for anti-adipogenic effects...
November 21, 2016: Food & Function
https://www.readbyqxmd.com/read/27867770/soymilk-residue-okara-as-a-natural-immobilization-carrier-for-lactobacillus-plantarum-cells-enhances-soymilk-fermentation-glucosidic-isoflavone-bioconversion-and-cell-survival-under-simulated-gastric-and-intestinal-conditions
#7
Xia Xiudong, Wang Ying, Liu Xiaoli, Li Ying, Zhou Jianzhong
Cell immobilization is an alternative to microencapsulation for the maintenance of cells in a liquid medium. However, artificial immobilization carriers are expensive and pose a high safety risk. Okara, a food-grade byproduct from soymilk production, is rich in prebiotics. Lactobacilli could provide health enhancing effects to the host. This study aimed to evaluate the potential of okara as a natural immobilizer for L. plantarum 70810 cells. The study also aimed to evaluate the effects of okara-immobilized L...
2016: PeerJ
https://www.readbyqxmd.com/read/27866192/dietary-genistein-rescues-reduced-basal-chloride-secretion-in-diabetic-jejunum-via-sex-dependent-mechanisms
#8
Shawn Catmull, Faisal Masood, Sydney Schacht, Robert Dolan, Daniel Stegman, Lana Leung, Layla Al-Nakkash
BACKGROUND/AIMS: The goal of this study was to determine the effect of dietary genistein (naturally occurring phytoestrogen) on jejunal secretory function in a clinically relevant model of diabetes and obesity, the leptin-defIcient ob/ob mouse. METHODS: We measured transepithelial short circuit current (Isc), across freshly isolated segments of jejunum from 12-week old male and female ob/ob and lean C57Bl/6J mice fed a genistein diet (600 mg genistein/kg diet) for 4-weeks...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27864692/transglutaminase-2-is-involved-in-amyloid-beta1-42-induced-pro-inflammatory-activation-via-ap1-jnk-signalling-pathways-in-thp-1-monocytes
#9
Monica Currò, Chiara Gangemi, Maria Laura Giunta, Nadia Ferlazzo, Michele Navarra, Riccardo Ientile, Daniela Caccamo
Deposition of amyloid-beta (Aβ) peptides has been shown to induce the release of inflammatory factors by activated microglia and brain infiltrating monocytes/macrophages. Interestingly, the enzyme transglutaminase 2 (TG2) has been shown to play a key role in neuroinflammation and regulation of transcription factors involved in immunomodulation. In this study, we aimed to better elucidate the mechanisms underlying TG2 involvement in the pro-inflammatory signaling pathway activated by fibrillar Aβ1-42 in THP-1 monocytes...
November 18, 2016: Amino Acids
https://www.readbyqxmd.com/read/27861885/sensitivity-of-tp53-mutated-cancer-cells-to-the-phytoestrogen-genistein-is-associated-with-direct-inhibition-of-plk1-activity
#10
Sol-Bi Shin, Sang-Uk Woo, Young Won Chin, Young-Joo Jang, Hyungshin Yim
Polo-like kinase 1 (Plk1), a conserved Ser/Thr mitotic kinase, has been identified as a promising target for anticancer drug development because its overexpression is correlated with malignancy. Here, we found that genistein, an isoflavone, inhibits Plk1 kinase activity directly. Previously the mitotic disturbance phenomenon induced by treatment with genistein was not fully explained by its inhibitory effect on EGFR. In kinase profiling assays, it showed selectivity relative to a panel of kinases, including EGFR...
November 9, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27834834/the-cooperative-effect-of-genistein-and-protein-hydrolysates-on-the-proliferation-and-survival-of-osteoblastic-cells-hfob-1-19
#11
Shuo Wang, Yu Fu, Xin-Huai Zhao
Chum salmon skin gelatin, de-isoflavoned soy protein, and casein were hydrolyzed at two degrees of hydrolysis. Genistein, the prepared hydrolysates, and genistein-hydrolysate combinations were assessed for their proliferative and anti-apoptotic effects on human osteoblasts (hFOB 1.19) to clarify potential cooperative effects between genistein and these hydrolysates in these two activities. Genistein at 2.5 μg/L demonstrated the highest proliferative activity, while the higher dose of genistein inhibited cell growth...
November 8, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27834809/bidirectional-estrogen-like-effects-of-genistein-on-murine-experimental-autoimmune-ovarian-disease
#12
Qiao Ding, Yuxiao Wang, Na Li, Kexue Zhu, Jielun Hu, Sunan Wang, Fan Zhu, Shaoping Nie
This study was to investigate the bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease (AOD). Female BALB/c mice were induced by immunization with a peptide from murine zona pellucida. The changes of estrous cycle, ovarian histomorphology were measured, and the levels of serum sex hormone were analyzed using radioimmunoassay. Proliferative responses of the ovary were also determined by immunohistochemistry. Administration of 25 or 45 mg/kg body weight genistein enhanced ovary development with changes in serum sex hormone levels and proliferative responses...
November 8, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27826811/inducible-de-novo-biosynthesis-of-isoflavonoids-in-soybean-leaves-by-spodoptera-litura-derived-elicitors-tracer-techniques-aided-by-high-resolution-lcms
#13
Ryu Nakata, Yuki Kimura, Kenta Aoki, Naoko Yoshinaga, Masayoshi Teraishi, Yutaka Okumoto, Alisa Huffaker, Eric A Schmelz, Naoki Mori
Isoflavonoids are a characteristic family of natural products in legumes known to mediate a range of plant-biotic interactions. For example, in soybean (Glycine max: Fabaceae) multiple isoflavones are induced and accumulate in leaves following attack by Spodoptera litura (Lepidoptera: Noctuidae) larvae. To quantitatively examine patterns of activated de novo biosynthesis, soybean (Var. Enrei) leaves were treated with a combination of plant defense elicitors present in S. litura gut content extracts and L-α-[(13)C9, (15)N]phenylalanine as a traceable isoflavonoid precursor...
November 8, 2016: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/27809235/protective-effect-of-genistein-against-neuronal-degeneration-in-apoe-mice-fed-a-high-fat-diet
#14
Yoon-Jin Park, Je Won Ko, Sookyoung Jeon, Young Hye Kwon
Altered cholesterol metabolism is believed to play a causal role in major pathophysiological changes in neurodegeneration. Several studies have demonstrated that the absence of apolipoprotein E (ApoE), a predominant apolipoprotein in the brain, leads to an increased susceptibility to neurodegeneration. Previously, we observed that genistein, a soy isoflavone, significantly alleviated apoptosis and tau hyperphosphorylation in SH-SY5Y cells. Therefore, we investigated the neuroprotective effects of dietary genistein supplementation (0...
October 31, 2016: Nutrients
https://www.readbyqxmd.com/read/27798679/modification-of-hypoxic-respiratory-response-by-protein-tyrosine-kinase-in-brainstem-ventral-respiratory-neuron-group
#15
Hui Wang, Ruituo Huai, Junqing Yang, Yanchun Li
Protein tyrosine kinase (PTK) mediated the tyrosine phosphorylation modification of neuronal receptors and ion channels. Whether such modification resulted in changes of physiological functions was not sufficiently studied. In this study we examined whether the hypoxic respiratory response-which is the enhancement of breathing in hypoxic environment could be affected by the inhibition of PTK at brainstem ventral respiratory neuron column (VRC). Experiments were performed on urethane anesthetized adult rabbits...
2016: PloS One
https://www.readbyqxmd.com/read/27797200/correction-to-protective-effects-of-genistein-and-puerarin-against-chronic-alcohol-induced-liver-injury-in-mice-via-antioxidant-anti-inflammatory-and-anti-apoptotic-mechanisms
#16
Liang Zhao, Yong Wang, Jia Liu, Kai Wang, Xiaoxuan Guo, Baoping Ji, Wei Wu, Feng Zhou
No abstract text is available yet for this article.
October 31, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27796744/molecular-and-therapeutic-targets-of-genistein-in-alzheimer-s-disease
#17
REVIEW
Kasi Pandima Devi, Balakrishnan Shanmuganathan, Azadeh Manayi, Seyed Fazel Nabavi, Seyed Mohammad Nabavi
Alzheimer's disease (AD) is a devastating brain disorder characterized by an increased level of amyloid-beta (Aβ) peptide deposition and neuronal cell death leading to an impairment of learning and thinking skills. The Aβ deposition is a key factor in senile plaques of the AD brain which cause the elevation of intracellular calcium ions and the production of formidable free radicals, both of which greatly contribute to the AD-associated cascade, leading to unstoppable neuronal loss in the hippocampal region of the brain...
October 28, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27796393/the-effect-of-geniste-on-a%C3%AE-25-35-induced-pc12-cell-apoptosis-through-the-jnk-dependent-fas-pathway
#18
Yaojie Zheng, Fuling You, Qiao Li, Jingrong Chen, Hong Yang
The β-amyloid protein (Aβ) is considered to be the key factor for inducing Alzheimer's disease (AD). In recent years, the neuroprotective effects of genistein have drawn increasing attention. However, the molecular mechanisms of GEN (genistein) against Aβ are unclear. In the present study, we investigated the inhibitory effects of GEN on Aβ25-35-induced apoptosis in cultured PC12 cells and the related signaling pathway. Our data show that GEN significantly inhibited Aβ25-35-induced apoptosis of PC12 cells...
October 31, 2016: Food & Function
https://www.readbyqxmd.com/read/27792907/exposure-to-endocrine-disrupting-chemicals-among-residents-of-a-rural-vegetarian-vegan-community
#19
Karen Tordjman, Laura Grinshpan, Lena Novack, Thomas Göen, Dar Segev, Lisa Beacher, Naftali Stern, Tamar Berman
BACKGROUND & AIMS: Endocrine-disrupting chemicals (EDCs) are increasingly thought to be involved in the rising prevalence of disorders such as obesity, diabetes, and some hormone-dependent cancers. Several lines of evidence have indicated that vegetarian and vegan diets may offer some protection from such diseases. We hypothesized that exposure to selected EDCs among residents of the unique vegetarian/vegan community of Amirim would be lower than what has recently been reported for the omnivorous population in the first Israel Biomonitoring Study (IBMS)...
October 25, 2016: Environment International
https://www.readbyqxmd.com/read/27785742/combined-effects-of-phytoestrogen-genistein-and-silicon-on-ovariectomy-induced-bone-loss-in-rat
#20
Shanshan Qi, Hongxing Zheng
This study was performed to evaluate the effect of concomitant supplementation of genistein and silicon on bone mineral density and bone metabolism-related markers in ovariectomized rat. Three-month-old Sprague Dawley female rats were subjected to bilateral ovariectomy (OVX) or sham surgery, and then the OVX rats were randomly divided into four groups: OVX-GEN, OVX-Si, OVX-GEN-Si, and OVX. Genistein and silicon supplementation was started immediately after OVX and continued for 10 weeks. In the OVX-GEN group, 5 mg genistein per gram body weight was injected subcutaneously...
October 26, 2016: Biological Trace Element Research
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