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canine osteoarthritis

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https://www.readbyqxmd.com/read/28334450/short-term-effects-of-arthrotomy-with-and-without-infrapatellar-fat-pad-resection-on-the-normal-canine-stifle
#1
Yukihiro Fujita, Tetsuya Nakajo, Makoto Muto
OBJECTIVE: To investigate the short-term effects of infrapatellar fat pad (IFP) resection in normal dogs. STUDY DESIGN: Experimental in vivo study. ANIMALS: Five normal adult female beagle dogs. METHODS: The IFP was resected via arthrotomy in the left stifle joint (experimental side) while the right stifle underwent arthrotomy alone (sham side). An orthopedic examination was performed every week for 4 weeks and synovial fluid was analyzed before and 4 weeks after the procedure...
March 23, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28331832/glucosamine-and-chondroitin-use-in-canines-for-osteoarthritis-a-review
#2
REVIEW
Angel Bhathal, Meredith Spryszak, Christopher Louizos, Grace Frankel
Osteoarthritis is a slowly progressive and debilitating disease that affects canines of all breeds. Pain and decreased mobility resulting from osteoarthritis often have a negative impact on the affected canine's quality of life, level of comfort, daily functioning, activity, behaviour, and client-pet companionship. Despite limited and conflicting evidence, the natural products glucosamine hydrochloride (HCl) and chondroitin sulfate are commonly recommended by veterinarians for treating osteoarthritis in dogs...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28327134/the-effect-of-intra-articular-botulinum-toxin-a-on-substance-p-prostaglandin-e2-and-tumor-necrosis-factor-alpha-in-the-canine-osteoarthritic-joint
#3
Helka M Heikkilä, Anna K Hielm-Björkman, John F Innes, Outi M Laitinen-Vapaavuori
BACKGROUND: Recently, intra-articular botulinum toxin A (IA BoNT A) has been shown to reduce joint pain in osteoarthritic dogs. Similar results have been reported in human patients with arthritis. However, the mechanism of the antinociceptive action of IA BoNT A is currently not known. The aim of this study was to explore this mechanism of action by investigating the effect of IA BoNT A on synovial fluid (SF) and serum substance P (SP), prostaglandin E2 (PGE2), and tumor necrosis factor alpha (TNF-α) in osteoarthritic dogs...
March 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28291395/prospective-evaluation-of-intra-articular-dextrose-prolotherapy-for-treatment-of-osteoarthritis-in-dogs
#4
J Matthew Sherwood, James K Roush, Laura J Armbrust, Walter C Renberg
The objective of this study was to evaluate intra-articular dextrose prolotherapy for osteoarthritis of the elbow or stifle in dogs in a randomized, double-blind, placebo-controlled, prospective pilot study. Seventeen dogs were evaluated with 10 meeting inclusion criteria for this study. Evaluations included orthopedic exam, visual lameness scoring, Canine Brief Pain Inventory (CBPI), goniometry, kinetic gait analysis, and radiography. Initial lameness score, age, body weight, duration of lameness, and CBPI scores did not differ between groups...
March 14, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28197017/characterization-and-therapeutic-application-of-canine-adipose-mesenchymal-stem-cells-to-treat-elbow-osteoarthritis
#5
Éva Kriston-Pál, Ágnes Czibula, Zoltán Gyuris, Gyula Balka, Antal Seregi, Farkas Sükösd, Miklós Süth, Endre Kiss-Tóth, Lajos Haracska, Ferenc Uher, Éva Monostori
Visceral adipose tissue (AT) obtained from surgical waste during routine ovariectomies was used as a source for isolating canine mesenchymal stem cells (MSCs). As determined by cytofluorimetry, passage 2 cells expressed MSC markers CD44 and CD90 and were negative for lineage-specific markers CD34 and CD45. The cells differentiated toward osteogenic, adipogenic, and chondrogenic directions. With therapeutic aims, 30 dogs (39 joints) suffering from elbow dysplasia (ED) and osteoarthritis (OA) were intra-articularly transplanted with allogeneic MSCs suspended in 0...
January 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28114312/static-posturography-a-new-perspective-in-the-assessment-of-lameness-in-a-canine-model
#6
Maria E Manera, José M Carrillo, Miguel Batista, Monica Rubio, Joaquin Sopena, Angelo Santana, José M Vilar
The aim of this study was to assess the static posturography in dogs as a useful tool for diagnosis of lameness by means of the use of a pressure platform. For this purpose, a series of different parameters (pressure distribution, area of support, mean pressure, maximum pressure and statokinesiograms) were obtained from five lame dogs with unilateral elbow osteoarthritis treated with plasma rich in growth factors. Data were obtained before and 3 months after treatment, and results were compared with a control group of sound dogs of similar conformation...
2017: PloS One
https://www.readbyqxmd.com/read/28094860/tta-rapid-in-the-treatment-of-the-canine-cruciate-deficient-stifle-short-and-medium-term-outcome
#7
S J Butterworth, D M Kydd
OBJECTIVES: To evaluate complications, short- and medium-term outcomes following treatment of lameness associated with cranial cruciate ligament insufficiency in dogs using the "TTA-Rapid" technique. METHODS: Patient records from two veterinary clinics were retrospectively examined to collect data from cases treated over a period of 21 months. An owner postal questionnaire using a clinical metrology instrument (Liverpool Osteoarthritis in Dogs) evaluated medium-term outcome of at least six months...
January 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28094414/asymmetrical-lumbosacral-transitional-vertebrae-in-dogs-may-promote-asymmetrical-hip-joint-development
#8
Mark A Flückiger, Frank Steffen, Michael Hässig, Joseph P Morgan
OBJECTIVES: This study examines the relationship between the morphology of the lumbosacral transitional vertebra (LTV) and asymmetrical development of the hip joints in dogs. METHODS: A total of 4000 dogs which had been consecutively scored for canine hip dysplasia were checked for the presence of a LTV. A LTV was noted in 138 dogs and classified depending on the morphology of the transverse processes and the degree of contact with the ilium. RESULTS: In dogs with an asymmetrical LTV, the hip joint was significantly more predisposed to subluxation and malformation on the side of the intermediate or sacral-like transverse process (p <0...
January 17, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28090443/topographical-and-depth-dependent-glycosaminoglycan-concentration-in-canine-medial-tibial-cartilage-3-weeks-after-anterior-cruciate-ligament-transection-surgery-a-microscopic-imaging-study
#9
Daniel Mittelstaedt, David Kahn, Yang Xia
BACKGROUND: Medical imaging has become an invaluable tool to diagnose damage to cartilage. Depletion of glycosaminoglycans (GAG) has been shown to be one of the early signs of cartilage degradation. In order to investigate the topographical changes in GAG concentration caused by the anterior cruciate ligament transection (ACLT) surgery in a canine model, microscopic magnetic resonance imaging (µMRI) and microscopic computed tomography (µCT) were used to measure the GAG concentration with correlation from a biochemical assay, inductively coupled plasma optical emission spectroscopy (ICP-OES), to understand where the topographical and depth-dependent changes in the GAG concentration occur...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28024306/a-canine-arthroscopic-anterior-cruciate-ligament-reconstruction-model-for-study-of-synthetic-augmentation-of-tendon-allografts
#10
James L Cook, Pat Smith, James P Stannard, Ferris Pfeiffer, Keiichi Kuroki, Chantelle C Bozynski, Cristi Cook
Novel graft types, fixation methods, and means for augmenting anterior cruciate ligament (ACL) reconstructions require preclinical validation prior to safe and effective clinical application. The objective of this study was to describe and validate a translational canine model for all-inside arthroscopic complete ACL reconstruction using a quadriceps tendon allograft with internal brace (QTIB). With institutional approval, adult research hounds underwent complete transection of the native ACL followed by all-inside ACL reconstruction using the novel QTIB construct with suspensory fixation (n = 10)...
December 26, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27989366/dental-and-temporomandibular-joint-pathology-of%C3%A2-the-american-black-bear-ursus-americanus
#11
E J Clark, S R Chesnutt, J N Winer, P H Kass, F J M Verstraete
Museum specimens (maxillae and/or mandibles) from 371 American black bears (Ursus americanus) acquired between 1889 and 2006 were examined macroscopically according to predefined criteria, and 348 were included in this study. Of the 348 specimens, 126 (36.2%) were from male animals, 106 (30.5%) were from female animals and 116 (33.3%) were from animals of unknown sex. Specimen ages ranged from young adult (n = 63, 18.1%) to adult (n = 285, 81.9%), with juveniles excluded from the study. The number of teeth available for examination was 12,019 (82...
December 15, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27793205/measurement-of-serum-c-reactive-protein-concentration-for-discriminating-between-suppurative-arthritis-and-osteoarthritis-in-dogs
#12
Anna Hillström, Jonas Bylin, Ragnvi Hagman, Karin Björhall, Harold Tvedten, Kristian Königsson, Tove Fall, Mads Kjelgaard-Hansen
BACKGROUND: In a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic tests and treatments. The aim of this study was to evaluate whether measurement of serum C-reactive protein (CRP) concentration could be used to discriminate between dogs with suppurative arthritis and osteoarthritis (OA). Furthermore, the concentrations of serum and synovial fluid interleukin (IL) 6 concentrations were measured in dogs with joint disease and in healthy dogs, and were correlated to serum CRP concentrations...
October 28, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27597397/pharmacology-of-grapiprant-a-novel-ep4-antagonist-receptor-binding-efficacy-in-a-rodent-postoperative-pain-model-and-a-dose-estimation-for-controlling-pain-in-dogs
#13
A Nagahisa, T Okumura
Grapiprant is an analgesic and anti-inflammatory drug in the piprant class that was approved in March 2016 by FDA's Center for Veterinary Medicine for the control of pain and inflammation associated with osteoarthritis (OA) in dogs. Grapiprant functions as a selective antagonist of the EP4 receptor, one of the four prostaglandin E2 (PGE2 ) receptor subtypes. The EP4 receptor mediates PGE2 -elicited nociception, and grapiprant has been shown to decrease pain in several rat inflammatory pain models. It was also effective in reducing pain associated with OA in humans, providing evidence for its mechanism of action in these species...
September 6, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27580105/effects-of-administration-of-adipose-derived-stromal-vascular-fraction-and-platelet-rich-plasma-to-dogs-with-osteoarthritis-of-the-hip-joints
#14
David A Upchurch, Walter C Renberg, James K Roush, George A Milliken, Mark L Weiss
OBJECTIVE To evaluate effects of simultaneous intra-articular and IV injection of autologous adipose-derived stromal vascular fraction (SVF) and platelet-rich plasma (PRP) to dogs with osteoarthritis of the hip joints. ANIMALS 22 client-owned dogs (12 placebo-treated [control] dogs and 10 treated dogs). PROCEDURES Dogs with osteoarthritis of the hip joints that caused signs of lameness or discomfort were characterized on the basis of results of orthopedic examination, goniometry, lameness score, the Canine Brief Pain Inventory (CBPI), a visual analogue scale, and results obtained by use of a pressure-sensing walkway at week 0 (baseline)...
September 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27575050/autologous-bone-marrow-derived-mesenchymal-stem-cells-modulate-molecular-markers-of-inflammation-in-dogs-with-cruciate-ligament-rupture
#15
Peter Muir, Eric C Hans, Molly Racette, Nicola Volstad, Susannah J Sample, Caitlin Heaton, Gerianne Holzman, Susan L Schaefer, Debra D Bloom, Jason A Bleedorn, Zhengling Hao, Ermias Amene, M Suresh, Peiman Hematti
Mid-substance rupture of the canine cranial cruciate ligament rupture (CR) and associated stifle osteoarthritis (OA) is an important veterinary health problem. CR causes stifle joint instability and contralateral CR often develops. The dog is an important model for human anterior cruciate ligament (ACL) rupture, where rupture of graft repair or the contralateral ACL is also common. This suggests that both genetic and environmental factors may increase ligament rupture risk. We investigated use of bone marrow-derived mesenchymal stem cells (BM-MSCs) to reduce systemic and stifle joint inflammatory responses in dogs with CR...
2016: PloS One
https://www.readbyqxmd.com/read/27566551/evaluating-oxidative-stress-serological-and-haematological-status-of-dogs-suffering-from-osteoarthritis-after-supplementing-their-diet-with-fish-or-corn-oil
#16
Stella Maria Barrouin-Melo, Johanna Anturaniemi, Satu Sankari, Mikko Griinari, Faik Atroshi, Sakaewan Ounjaijean, Anna Katrina Hielm-Björkman
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of disease, and the antioxidant physiological effect of omega-3 from fish oil may lead to improvement of canine spontaneous osteoarthritis (OA). METHODS: In this prospective randomized, controlled, double-blinded study, we assessed haematological and biochemical parameters in dogs with OA following supplementation with either a concentrated omega-3 deep sea fish oil product or corn oil. Blood samples from 77 client-owned dogs diagnosed as having OA were taken before (baseline) and 16 weeks after having orally ingested 0...
August 26, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27544261/the-attitudes-of-owners-and-veterinary-professionals-in-the-united-kingdom-to-the-risk-of-adverse-events-associated-with-using-non-steroidal-anti-inflammatory-drugs-nsaids-to-treat-dogs-with-osteoarthritis
#17
Zoe Belshaw, Lucy Asher, Rachel S Dean
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed by veterinary surgeons for the treatment of canine osteoarthritis, and affected dogs may receive these drugs for long periods of time. Whilst short term administration of NSAIDs to dogs is linked to adverse events such as gastrointestinal haemorrhage and renal injury, reports of adverse events associated with their long-term administration are limited in the veterinary literature. This study aimed to investigate the attitudes towards the long term use of NSAIDs for canine osteoarthritis held by three groups who manage osteoarthritic dogs in the United Kingdom: dog owners, veterinary surgeons and veterinary nurses...
September 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27530539/dental-and-temporomandibular-joint-pathology-of-the-walrus-odobenus-rosmarus
#18
J N Winer, B Arzi, D M Leale, P H Kass, F J M Verstraete
Maxillae and/or mandibles from 76 walruses (Odobenus rosmarus) were examined macroscopically according to predefined criteria. The museum specimens were acquired between 1932 and 2014. Forty-five specimens (59.2%) were from male animals, 29 (38.2%) from female animals and two (2.6%) from animals of unknown sex, with 58 adults (76.3%) and 18 young adults (23.7%) included in this study. The number of teeth available for examination was 830 (33.6%); 18.5% of teeth were absent artefactually, 3.3% were deemed to be absent due to acquired tooth loss and 44...
August 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27525982/functional-outcome-measures-in-a-surgical-model-of-hip-osteoarthritis-in-dogs
#19
Dianne Little, Stephen Johnson, Jonathan Hash, Steven A Olson, Bradley T Estes, Franklin T Moutos, B Duncan X Lascelles, Farshid Guilak
BACKGROUND: The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip, and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27439659/evaluation-of-surface-blood-flow-in-intact-and-ruptured-canine-cruciate-ligaments-using-laser-doppler-flowmetry
#20
Joakim Testuz, Judith Howard, Antonio Pozzi, Ulrich Rytz, Christiane Krudewig, David Spreng, Simone Forterre
OBJECTIVE: To evaluate the usefulness of laser Doppler flowmetry (LDF) to measure surface blood flow in canine cruciate ligaments, compare measurements in different sites of intact and partially ruptured canine cranial cruciate ligaments (CrCL) and intact caudal cruciate ligaments (CaCL), and investigate any association between surface blood flow in partially ruptured CrCL and synovitis or duration of clinical signs. STUDY DESIGN: Case-controlled clinical study...
September 20, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
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