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canine osteoarthritis

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https://www.readbyqxmd.com/read/29775732/il4-10-fusion-protein-has-chondroprotective-anti-inflammatory-and-potentially-analgesic-effects-in-the-treatment-of-osteoarthritis
#1
C Steen-Louws, J Popov-Celeketic, S C Mastbergen, K Coeleveld, C E Hack, N Eijkelkamp, M Tryfonidou, S Spruijt, J A G van Roon, F P J G Lafeber
OBJECTIVE: Effective disease-modifying drugs for osteoarthritis (DMOAD) should preferably have chondroprotective, anti-inflammatory, and analgesic activity combined in a single molecule. We developed a fusion protein of IL4 and IL10 (IL4-10 FP), in which the biological activity of both cytokines is preserved. The present study evaluates the chondroprotective, anti-inflammatory, and analgesic activity of IL4-10 FP in in vitro and in vivo models of osteoarthritis. METHODS: Human osteoarthritic cartilage tissue and synovial tissue were cultured with IL4-10 FP...
May 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29772338/hyaluronic-acid-an-efficient-biomacromolecule-for-treatment-of-inflammatory-skin-and-joint-diseases-a-review-of-recent-developments-and-critical-appraisal-of-preclinical-and-clinical-investigations
#2
REVIEW
Li Hui Chen, Jian Feng Xue, Zhi Yong Zheng, Muhammad Shuhaidi, Hnin Ei Thu, Zahid Hussain
Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29769086/inflammatory-pattern-of-the-infrapatellar-fat-pad-in-dogs-with-canine-cruciate-ligament-disease
#3
Manuel R Schmidli, Bettina Fuhrer, Nadine Kurt, David Senn, Michaela Drögemüller, Ulrich Rytz, David E Spreng, Simone Forterre
BACKGROUND: Despite the importance of inflammation during the pathogenesis of cranial cruciate ligament disease (CCLD) in dogs and despite the latest knowledge suggesting a significant role of adipose tissue in osteoarthritis, the infrapatellar fat pad (IFP) was up to now mostly disregarded in veterinary investigations. In the present study, the inflammatory activity of the IFP, the main adipose structure within the stifle joint, was thoroughly investigated to evaluate its potential impact in the pathogenesis of this common disease of our canine companions...
May 16, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29720166/inhibitory-effects-of-sodium-pentosan-polysulfate-on-formation-and-function-of-osteoclasts-derived-from-canine-bone-marrow
#4
H M Suranji Wijekoon, Eugene C Bwalya, Jing Fang, Sangho Kim, Kenji Hosoya, Masahiro Okumura
BACKGROUND: Sodium pentosan polysulfate (NaPPS) was testified as a chondroprotective drug in with a detailed rationale of the disease-modifying activity. This study was undertaken to determine whether anti-osteoarthritis drug, NaPPS inhibited osteoclasts (OC) differentiation and function. Canine bone marrow mononuclear cells (n = 6) were differentiated to OC by maintaining with receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) for up to 7 days with the treatment of NaPPS at concentration of 0, 0...
May 2, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29713636/the-pathobiology-of-the-meniscus-a-comparison-between-the-human-and-dog
#5
REVIEW
Olga Krupkova, Lucas Smolders, Karin Wuertz-Kozak, James Cook, Antonio Pozzi
Serious knee pain and related disability have an annual prevalence of approximately 25% on those over the age of 55 years. As curative treatments for the common knee problems are not available to date, knee pathologies typically progress and often lead to osteoarthritis (OA). While the roles that the meniscus plays in knee biomechanics are well characterized, biological mechanisms underlying meniscus pathophysiology and roles in knee pain and OA progression are not fully clear. Experimental treatments for knee disorders that are successful in animal models often produce unsatisfactory results in humans due to species differences or the inability to fully replicate disease progression in experimental animals...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29713634/cell-based-therapies-for-joint-disease-in-veterinary-medicine-what-we-have-learned-and-what-we-need-to-know
#6
REVIEW
Sophie Helen Bogers
Biological cell-based therapies for the treatment of joint disease in veterinary patients include autologous-conditioned serum, platelet-rich plasma, and expanded or non-expanded mesenchymal stem cell products. This narrative review outlines the processing and known mechanism of action of these therapies and reviews current preclinical and clinical efficacy in joint disease in the context of the processing type and study design. The significance of variation for biological activity and consequently regulatory approval is also discussed...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29704933/face-validity-of-a-proposed-tool-for-staging-canine-osteoarthritis-canine-osteoarthritis-staging-tool-coast
#7
T Cachon, O Frykman, J F Innes, B D X Lascelles, M Okumura, P Sousa, F Staffieri, P V Steagall, B Van Ryssen
No abstract text is available yet for this article.
May 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29697148/influence-of-class-iv-laser-therapy-on-the-outcomes-of-tibial-plateau-leveling-osteotomy-in-dogs
#8
S Michelle Renwick, Alasdair I Renwick, David C Brodbelt, John Ferguson, Humberto Abreu
OBJECTIVE: To determine the effects of low-level laser therapy (LLLT) on clinical outcomes in dogs with cranial cruciate ligament disease treated with tibial plateau leveling osteotomy (TPLO). STUDY DESIGN: Randomized, placebo-controlled clinical trial. Owners and surgeons (care providers and assessors) were masked. ANIMALS: Ninety-five dogs were admitted for TPLO and assigned to 1 of 2 groups, laser group (LG; n = 51) or placebo group (PG; n = 44)...
April 26, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29643866/joint-genomic-prediction-of-canine-hip-dysplasia-in-uk-and-us-labrador-retrievers
#9
Stefan M Edwards, John A Woolliams, John M Hickey, Sarah C Blott, Dylan N Clements, Enrique Sánchez-Molano, Rory J Todhunter, Pamela Wiener
Canine hip dysplasia, a debilitating orthopedic disorder that leads to osteoarthritis and cartilage degeneration, is common in several large-sized dog breeds and shows moderate heritability suggesting that selection can reduce prevalence. Estimating genomic breeding values require large reference populations, which are expensive to genotype for development of genomic prediction tools. Combining datasets from different countries could be an option to help build larger reference datasets without incurring extra genotyping costs...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29618832/prevalence-duration-and-risk-factors-for-appendicular-osteoarthritis-in-a-uk-dog-population-under-primary-veterinary-care
#10
Katharine L Anderson, Dan G O'Neill, David C Brodbelt, David B Church, Richard L Meeson, David Sargan, Jennifer F Summers, Helen Zulch, Lisa M Collins
Osteoarthritis is the most common joint disease diagnosed in veterinary medicine and poses considerable challenges to canine welfare. This study aimed to investigate prevalence, duration and risk factors of appendicular osteoarthritis in dogs under primary veterinary care in the UK. The VetCompassTM programme collects clinical data on dogs attending UK primary-care veterinary practices. The study included all VetCompassTM dogs under veterinary care during 2013. Candidate osteoarthritis cases were identified using multiple search strategies...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29574978/canine-total-hip-replacement-using-a-cementless-threaded-cup-and-stem-a-review-of-55-cases
#11
H R Denny, M Linnell, T W Maddox, E J Comerford
OBJECTIVES: To determine the long-term results and complications associated with the Helica® cementless hip endoprosthesis system. MATERIALS AND METHODS: Retrospective study of 55 consecutive Helica total hip replacements performed between January 2010 and February 2015. RESULTS: A total of 55 total hip replacements were performed in 50 dogs; 45 dogs had unilateral hip replacements, and five had staged bilateral replacements. A total of 23 first-generation short femoral stems were implanted in 22 dogs, of which nine cases (39%) experienced complications and 19 (86%) recovered satisfactorily when revisions were included; 31 second-generation femoral stems were implanted in 28 dogs, of which 10 cases (32%) experienced complications, and 26 (93%) made satisfactory recoveries, including revisions...
March 25, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29558919/a-step-in-the-right-direction-an-open-design-pedometer-algorithm-for-dogs
#12
C Ladha, Z Belshaw, J O'Sullivan, L Asher
BACKGROUND: Accelerometer-based technologies could be useful in providing objective measures of canine ambulation, but most are either not tailored to the idiosyncrasies of canine gait, or, use un-validated or closed source approaches. The aim of this paper was to validate algorithms which could be applied to accelerometer data for i) counting the number of steps and ii) distance travelled by a dog. To count steps, an approach based on partitioning acceleration was used. This was applied to accelerometer data from 13 dogs which were walked a set distance and filmed...
March 20, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29554150/effect-of-leukocyte-reduced-platelet-rich-plasma-on-osteoarthritis-caused-by-cranial-cruciate-ligament-rupture-a-canine-gait-analysis-model
#13
José M Vilar, Maria E Manera, Angelo Santana, Giuseppe Spinella, Oliver Rodriguez, Mónica Rubio, José M Carrillo, Joaquín Sopena, Miguel Batista
The goal of this study was to objectively assess the effect of a platelet-rich plasma (PRP) derivate in English bulldogs with stifle degenerative joint disease secondary to cranial cruciate ligament rupture (CCLR). We used a force platform and affixed electrogoniometers to measure peak vertical force (PVF), vertical impulse (VI), stance time (ST), and angular range of motion (AROM), from 12 lame client-owned English bulldogs with post-CCLR stifle joint abnormalities. The 12 affected subjects were treated with 4 intra-articular injections of PRP, at 30-day intervals...
2018: PloS One
https://www.readbyqxmd.com/read/29534278/magnetic-resonance-imaging-t2-values-of-stifle-articular-cartilage-in-normal-beagles
#14
Sarah L Pownder, Kei Hayashi, Brian G Caserto, Mary Lou Norman, Hollis G Potter, Matthew F Koff
OBJECTIVES:  The purpose of this study was to evaluate regional differences of canine stifle articular cartilage using the quantitative magnetic resonance imaging (MRI) technique of T2 mapping. METHODS:  Fourteen stifle joints from seven juvenile male Beagle dogs with no evidence or prior history of pelvic limb lameness were imaged ex vivo using standard of care fast spin echo MRI and quantitative T2 mapping protocols. Regions of interest were compared between the femoral, patellar and tibial cartilages, as well as between the lateral and medial femorotibial compartments...
February 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29525231/effect-of-an-oral-joint-supplement-when-compared-to-carprofen-in-the-management-of-hip-osteoarthritis-in-working-dogs
#15
João Carlos Alves, Ana Margarida Santos, Patrícia Isabel Jorge
The goal of this study was to evaluate the effectiveness of an oral joint supplement in working dogs with hip osteoarthritis compared with a positive control group (CG). Fifteen animals were divided in treatment group (TG, n = 10) and CG (n = 5). To TG a commercially available joint supplement, containing glucosamine HCl, chondroitin sulphate, and hyaluronic acid was given for 40 days and a 70-day course of a placebo, to be administered as if it was carprofen. The CG received carprofen for 70 days, and a placebo to be administered as the joint supplement...
December 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/29521434/interaction-with-macrophages-attenuates-equine-fibroblast-like-synoviocyte-adamts5-aggrecanase-2-gene-expression-following-inflammatory-stimulation
#16
Rhiannon E Morgan, Peter D Clegg, John A Hunt, John F Innes, Simon R Tew
The joint synovium consists of a heterogeneous cell population, chiefly comprised of macrophages, and fibroblast-like synoviocytes (FLS). An inter-species co-culture model was developed to examine interactions between these cells. Equine FLS and the canine macrophage line DH82 were differentially labeled using fluorescent markers and results from direct co-culture compared with those from both indirect co-culture, and conditioned media experiments. The transcript expression of IL-1β, IL-6, ADAMTS4, and ADAMTS5 in each cell type were determined using species-specific qPCR assays...
March 9, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29504855/assessment-of-the-effects-of-diet-and-physical-rehabilitation-on-radiographic-findings-and-markers-of-synovial-inflammation-in-dogs-following-tibial-plateau-leveling-osteotomy
#17
Valentine D Verpaalen, Wendy I Baltzer, Sarah Smith-Ostrin, Jennifer J Warnock, Bernadette Stang, Craig G Ruaux
OBJECTIVE To determine the effects of an omega-3 fatty acid and protein-enriched diet, physical rehabilitation, or both on radiographic findings and markers of synovial inflammation in dogs following tibial plateau leveling osteotomy and arthroscopic surgery for treatment of cranial cruciate ligament disease. DESIGN Randomized, prospective clinical trial. ANIMALS 48 dogs with unilateral cranial cruciate ligament disease. PROCEDURES Dogs were randomly assigned to receive a dry omega-3 fatty acid and protein-enriched dog food formulated to support joint health (test food [TF]), a dry food formulated for adult canine maintenance (control food [CF]), TF plus rehabilitation, or CF plus rehabilitation after surgery...
March 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29393744/lack-of-effectiveness-of-tramadol-hydrochloride-for-the-treatment-of-pain-and-joint-dysfunction-in-dogs-with-chronic-osteoarthritis
#18
Steven C Budsberg, Bryan T Torres, Stephanie A Kleine, Gabriella S Sandberg, Amanda K Berjeski
OBJECTIVE To investigate the effectiveness of tramadol for treatment of osteoarthritis in dogs. DESIGN Randomized, blinded, placebo-controlled crossover study. ANIMALS 40 dogs with clinical osteoarthritis of the elbow or stifle joint. PROCEDURES Dogs orally received 3 times/d (morning, midday, and night) for a 10-day period each of 3 identically appearing treatments (placebo; carprofen at 2.2 mg/kg [1 mg/lb], q 12 h [morning and night], with placebo at midday; or tramadol hydrochloride at 5 mg/kg [2.3 mg/lb], q 8 h) in random order, with treatment sessions separated by a minimum 7-day washout period...
February 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29227567/canine-hip-dysplasia-a-natural-animal-model-for-human-developmental-dysplasia-of-the-hip
#19
Cecilia Pascual-Garrido, Farshid Guilak, M Farooq Rai, Michael D Harris, Mandi J Lopez, Rory J Todhunter, John C Clohisy
Developmental dysplasia of the hip (DDH) in humans is a common condition that is associated with hip pain, functional limitations, and secondary osteoarthritis (OA). Surgical treatment of DDH has improved in the last decade, allowing excellent outcomes at short- and mid-term follow-up. Still, the etiology, mechanobiology, and pathology underlying this disease are not well understood. A pre-clinical animal model of DDH could help advance the field with a deeper understanding of specific pathways that initiate hip joint degeneration secondary to abnormal biomechanics...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29202500/evaluation-of-the-environmental-bias-on-accelerometer-measured-total-daily-activity-counts-and-owner-survey-responses-in-dogs-with-osteoarthritis
#20
Erin M Katz, Ruth M Scott, Christopher B Thomson, Eileen Mesa, Richard Evans, Michael G Conzemius
Objective  To determine if environmental variables affect the average daily activity counts (AC) of dogs with osteoarthritis (OA) and/or owners' perception of their dog's clinical signs or quality of life. Methods  The AC and Canine Brief Pain Inventory (CBPI) owner questionnaires of 62 dogs with OA were compared with daily environmental variables including the following: average temperature (°C), high temperature (°C), low temperature (°C), relative humidity (%), total precipitation (mm), average barometric pressure (hPa) and total daylight hours...
November 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
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