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Veterinary stem cell

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https://www.readbyqxmd.com/read/28720291/mesenchymal-stem-cells-in-daily-veterinary-practice-are-we-there-yet
#1
EDITORIAL
Catharina De Schauwer
No abstract text is available yet for this article.
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28693305/comparison-the-characteristics-of-canine-adipose-tissue-derived-mesenchymal-stem-cells-extracted-from-different-sites-and-at-different-passage-numbers
#2
Kevin M Yaneselli, Cristiana Palma Kuhl, Paula Barros Terraciano, Fernanda de Los Santos de Oliveira, Sabrina Beal Pizzato, Kamila Pazza, Alessandra Bileski Magrisso, Vanessa Torman, Analía Rial, María Moreno, Silvia Llambí, Elizabeth Cirne Lima, Jacqueline Maisonnave
Mesenchymal Stem Cells (MSCs) have attractive characteristics for therapy in animal models and veterinary medicine, due to the capacity of inducing tissue regeneration and immunomodulation. The objective of this study was to evaluate the differences between canine adipose tissue-derived MSCs (AD-MSCs) extracted from subcutaneous (Sc) and visceral (Vs) sites. Surface antigenic markers, in vitro differentiation and mineralized matrix quantification of AD-MSCs in different passages (P4, P6 and P8) were studied...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28685064/identification-of-rhodamine-123-positive-stem-cell-subpopulations-in-canine-hepatocellular-carcinoma-cells
#3
Harumichi Itoh, Shimpei Nishikawa, Tomoya Haraguchi, Yu Arikawa, Masato Hiyama, Toshie Iseri, Yoshiki Itoh, Munekazu Nakaichi, Yasuho Taura, Kenji Tani, Kazuhito Itamoto
The majority of cases of chemotherapy for hepatocellular carcinoma (HCC) are not effective in human or veterinary medicine due to resistance against anticancer agents. In human medicine, hepatocellular carcinoma stem cells (HCSCs) were recently identified as cytokeratin 19 (CK19)-, cluster of differentiation (CD)-44-, and CD133-positive. However, there are few previous reports regarding canine HCSC (cHCSC). Additionally, to the best of our knowledge, the chemoresistance against anticancer agents of these cHCSCs has not been investigated...
July 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28656701/salinomycin-overcomes-acquired-tamoxifen-resistance-through-aib1-and-inhibits-cancer-cell-invasion-in-endocrine-resistant-breast-cancer
#4
Suwisit Manmuan, Nithidol Sakunrangsit, Wannarasmi Ketchart
Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus. It has been widely used as an antibiotic in veterinary medicine in poultry. A recent study demonstrated that salinomycin selectively inhibits human breast cancer stem cells; one possible mechanism of tamoxifen resistance. Our results show that salinomycin is effective in inhibiting MCF-7/LCC2 and MCF-7/LCC9 cell lines which are well-established endocrine resistant cells and has a synergistic effect in combination with tamoxifen using MTT proliferation assay...
June 28, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28643176/a-promising-tool-in-retina-regeneration-current-perspectives-and-challenges-when-using-mesenchymal-progenitor-stem-cells-in-veterinary-and-human-ophthalmological-applications
#5
REVIEW
Anna Cislo-Pakuluk, Krzysztof Marycz
Visual impairment is a common ailment of the current world population, with more exposure to CCD screens and fluorescent lighting, approximately 285 billion people suffer from this deficiency and 13% of those are considered clinically blind. More common causes for visual impairment include age-related macular degeneration (AMD), glaucoma and diabetic retinopathy (Zhu et al. Molecular Medicine Reports, 2015; Kolb et al. 2007; Machalińska et al. Current Eye Research, 34(9),748-760, 2009) among a few. As cases of retinal and optic nerve diseases rise, it is vital to find a treatment, which has led to investigation of the therapeutic potential of various stem cells types (Bull et al...
June 22, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28595579/omental-adipose-tissue-is-a-more-suitable-source-of-canine-mesenchymal-stem-cells
#6
Francisca Bahamondes, Estefania Flores, Gino Cattaneo, Flavia Bruna, Paulette Conget
BACKGROUND: Mesenchymal Stem Cells (MSCs) are a promising therapeutic tool in veterinary medicine. Currently the subcutaneous adipose tissue is the leading source of MSCs in dogs. MSCs derived from distinct fat depots have shown dissimilarities in their accessibility and therapeutic potential. The aims of our work were to determine the suitability of omental adipose tissue as a source of MSCs, according to sampling success, cell yield and paracrine properties of isolated cells, and compared to subcutaneous adipose tissue...
June 8, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28499392/experimental-tumor-growth-of-canine-osteosarcoma-cell-line-on-chick-embryo-chorioallantoic-membrane-in-vivo-studies
#7
Magdalena Walewska, Izabella Dolka, Anna Małek, Anna Wojtalewicz, Agata Wojtkowska, Artur Żbikowski, Roman Lechowski, Katarzyna Zabielska-Koczywąs
The chick embryo chorioallantoic membrane (CAM) model is extensively used in human medicine in preclinical oncological studies. The CAM model has several advantages: low cost, simple experimental approach, time saving and following "3R principles". Research has shown that the human osteosarcoma cell lines U2OS, MMNG-HOS, and SAOS can form tumors on the CAM. In veterinary medicine, this has been described only for feline fibrosarcomas, feline mammary carcinomas and canine osteosarcomas. However, in case of canine osteosarcomas, it has been shown that only non-adherent osteosarcoma stem cells isolated from KTOSA5 and CSKOS cell lines have the ability to form microtumors on the CAM after an incubation period of 5 days, in contrast to adherent KTOSA5 and CSKOS cells...
May 12, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28417917/minicircle-mediated-gene-delivery-to-canine-and-equine-mesenchymal-stem-cells
#8
Naomie Tidd, Jacob Michelsen, Bryan Hilbert, Jane C Quinn
Gene-directed tissue repair offers the clinician, human or veterinary, the chance to enhance cartilage regeneration and repair at a molecular level. Non-viral plasmid vectors have key biosafety advantages over viral vector systems for regenerative therapies due to their episomal integration however, conventional non-viral vectors can suffer from low transfection efficiency. Our objective was to identify and validate in vitro a novel non-viral gene expression vector that could be utilized for ex vivo and in vivo delivery to stromal-derived mesenchymal stem cells (MSCs)...
April 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28387349/targeting-microbial-biofilms-using-ficin-a-nonspecific-plant-protease
#9
Diana R Baidamshina, Elena Y Trizna, Marina G Holyavka, Mikhail I Bogachev, Valeriy G Artyukhov, Farida S Akhatova, Elvira V Rozhina, Rawil F Fakhrullin, Airat R Kayumov
Biofilms, the communities of surface-attached bacteria embedded into extracellular matrix, are ubiquitous microbial consortia securing the effective resistance of constituent cells to environmental impacts and host immune responses. Biofilm-embedded bacteria are generally inaccessible for antimicrobials, therefore the disruption of biofilm matrix is the potent approach to eradicate microbial biofilms. We demonstrate here the destruction of Staphylococcus aureus and Staphylococcus epidermidis biofilms with Ficin, a nonspecific plant protease...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341078/isolation-molecular-characterization-and-in%C3%A2-vitro-differentiation-of-bovine-wharton-jelly-derived-multipotent-mesenchymal-cells
#10
Anna Lange-Consiglio, Claudia Perrini, Alessia Bertero, Paola Esposti, Fausto Cremonesi, Leila Vincenti
Extrafetal tissues are a noncontroversial and inexhaustible source of mesenchymal stem cells that can be harvested noninvasively at low cost. In the veterinary field, as in man, stem cells derived from extrafetal tissues express plasticity, reduced immunogenicity, and have high anti-inflammatory potential making them promising candidates for treatment of many diseases. Umbilical cord mesenchymal cells have been isolated and characterized in different species and have recently been investigated as potential candidates in regenerative medicine...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28240438/feeder-independent-canine-induced-pluripotent-stem-cells-maintained-under-serum-free-conditions
#11
Toshiya Nishimura, Shingo Hatoya, Ryoji Kanegi, Daluthgamage Pasty Himali Wijesekera, Kousuke Sanno, Erina Tanaka, Kikuya Sugiura, Noritoshi Kawate Hiromitsu Tamada, Hiroshi Imai, Toshio Inaba
Canine induced pluripotent stem cells (ciPSCs) are an attractive source for regenerative veterinary medicine, and may also serve as a disease model for human regenerative medicine. Extending the application of ciPSCs from bench to bedside, however, requires resolving many issues. We generated ciPSCs expressing doxycycline-inducible murine Oct3/4 (Pou5f1), Sox2, Klf4, and c-Myc, which were introduced using lentiviral vectors. The resultant ciPSCs required doxycycline to proliferate in the undifferentiated state...
February 27, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28142381/questions-and-challenges-in-the-development-of-mesenchymal-stromal-stem-cell-based-therapies-in-veterinary-medicine
#12
Lax R Devireddy, Lynne Boxer, Michael J Myers, Mark Skasko, Rudell Screven
The therapeutic potential of stem cells has fascinated those interested in treating diseases in both human and animal subjects. Although the exact mechanism of action and the definitive effectiveness of stem cell therapies remain unclear, animal owner perceptions and a desire for improved treatment options have fueled the interest of clinicians and stakeholders. Standards do not yet exist to define the critical attributes of mesenchymal stem/stromal cell (MSC)-based products derived from veterinary species such as the dog, cat, and horse...
February 28, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28110374/morphological-description-of-limbal-epithelium-searching-for-stem-cells-crypts-in-the-dog-cat-pig-cow-sheep-and-horse
#13
M Patruno, A Perazzi, T Martinello, A Blaseotto, E Di Iorio, I Iacopetti
The cornea provides protection and transparency to the eye, allowing an optimal sharpness view. In some pathological conditions the cornea is able to regenerate thanks to the presence of a stem cells reservoir present at the level of the transition area between cornea and sclera (limbus). Corneal cell therapies in Veterinary Medicine are really limited due to the lacking of knowledge about the anatomy of the limbal area, the putative presence of stem cells and their identification in domestic species. The aim of this study was to provide an overview of the main distinctive structural features of the sclero-corneal junction and conjunctival-corneal junction areas in some species of veterinary importance, using optic microscope observations of histological sections...
January 21, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28096616/intravenous-administration-of-puppy-deciduous-teeth-stem-cells-in-degenerative-valve-disease
#14
Soontaree Petchdee, Sarunya Sompeewong
AIM: The objective of this study is to investigate the improvement of heart function in dogs with chronic valvular heart disease after puppy deciduous teeth stem cells (pDSCs) administration. MATERIALS AND METHODS: 20 client-owned dogs with degenerative valvular heart disease underwent multiple intravenous injections of allogeneic pDSCs. Dogs were randomly assigned to two groups: (i) Control group (n=10) with standard treatment for heart failure and (ii) group with standard treatment and multiple administrations of pDSCs (n=10)...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/27729913/utility-of-a-mouse-model-of-osteoarthritis-to-demonstrate-cartilage-protection-by-ifn%C3%AE-primed-equine-mesenchymal-stem-cells
#15
Marie Maumus, Gautier Roussignol, Karine Toupet, Geraldine Penarier, Isabelle Bentz, Sandrine Teixeira, Didier Oustric, Mireille Jung, Olivier Lepage, Regis Steinberg, Christian Jorgensen, Danièle Noel
OBJECTIVE: Mesenchymal stem cells isolated from adipose tissue (ASC) have been shown to influence the course of osteoarthritis (OA) in different animal models and are promising in veterinary medicine for horses involved in competitive sport. The aim of this study was to characterize equine ASCs (eASCs) and investigate the role of interferon-gamma (IFNγ)-priming on their therapeutic effect in a murine model of OA, which could be relevant to equine OA. METHODS: ASC were isolated from subcutaneous fat...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27695698/a-prospective-randomized-masked-and-placebo-controlled-efficacy-study-of-intraarticular-allogeneic-adipose-stem-cells-for-the-treatment-of-osteoarthritis-in-dogs
#16
Robert Harman, Kim Carlson, Jamie Gaynor, Scott Gustafson, Sarit Dhupa, Keith Clement, Michael Hoelzler, Tim McCarthy, Pamela Schwartz, Cheryl Adams
Osteoarthritis (OA) is a degenerative joint disease with a high prevalence in dogs. Mesenchymal stem cells (MSCs) have been used to treat humans, dogs, and horses with OA. This report describes a prospective, randomized, blinded, and placebo-controlled clinical efficacy study of intraarticular allogeneic adipose stem cells for the treatment of dogs with OA. Health assessments and measurements of pain and activity impairment were performed at baseline and at selected time points through day 60. The primary outcome variable was the owner Client-Specific Outcome Measurement (CSOM) and secondary measures included veterinary pain on manipulation, veterinary global score, and owner global score...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27590427/comparison-of-mesenchymal-stem-cells-and-leukocytes-from-large-white-and-g%C3%A3-ttingen-minipigs-clues-for-stem-cell-based-immunomodulatory-therapies
#17
COMPARATIVE STUDY
Verónica Álvarez, Francisco-Miguel Sánchez-Margallo, Rebeca Blázquez, Raquel Tarazona, Javier G Casado
The mesenchymal stem cells (MSCs) are one of the most promising cell types for human and veterinary use and their therapeutic effect is associated with their immunomodulatory properties. Farm animal models, such as pigs, have become a valuable tool to evaluate the safety and efficacy of adoptively transferred MSCs in the setting of veterinary medicine. In order to evaluate the immunomodulatory effect of stem cell-based therapies in porcine breeds, a deep analysis and comparison of MSCs and leukocyte subsets are absolutely necessary...
October 15, 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27575050/autologous-bone-marrow-derived-mesenchymal-stem-cells-modulate-molecular-markers-of-inflammation-in-dogs-with-cruciate-ligament-rupture
#18
Peter Muir, Eric C Hans, Molly Racette, Nicola Volstad, Susannah J Sample, Caitlin Heaton, Gerianne Holzman, Susan L Schaefer, Debra D Bloom, Jason A Bleedorn, Zhengling Hao, Ermias Amene, M Suresh, Peiman Hematti
Mid-substance rupture of the canine cranial cruciate ligament rupture (CR) and associated stifle osteoarthritis (OA) is an important veterinary health problem. CR causes stifle joint instability and contralateral CR often develops. The dog is an important model for human anterior cruciate ligament (ACL) rupture, where rupture of graft repair or the contralateral ACL is also common. This suggests that both genetic and environmental factors may increase ligament rupture risk. We investigated use of bone marrow-derived mesenchymal stem cells (BM-MSCs) to reduce systemic and stifle joint inflammatory responses in dogs with CR...
2016: PloS One
https://www.readbyqxmd.com/read/27520504/mammary-epithelial-cell-hierarchy-in-the-dairy-cow-throughout-lactation
#19
Marie-Hélène Perruchot, Magdalena Arévalo-Turrubiarte, Florence Dufreneix, Laurence Finot, Vanessa Lollivier, Eric Chanat, Frédérique Mayeur, Frédéric Dessauge
The plasticity of the mammary gland relies on adult mammary stem cells (MaSCs) and their progenitors, which give rise to various populations of mammary epithelial cells (MECs). To face global challenges, an in-depth characterization of milk-producing animal mammary gland plasticity is required, to select more sustainable and robust dairy cows. The identification and characterization of MaSC and their progenitors will also provide innovative tools in veterinary/human medicine regarding mammary tissue damage (carcinogenesis, bacterial infections)...
October 1, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27425208/isolation-and-biological-characterization-of-a-novel-type-of-pulmonary-mesenchymal-stem-cells-derived-from-wuzhishan-miniature-pig-embryo
#20
Caiyun Ma, Yu Guo, Hao Liu, Kunfu Wang, Jinjuan Yang, Xiangchen Li, Changqing Liu, Weijun Guan
Pulmonary mesenchymal stem cells (PMSCs) have great potential in lung tissue engineering and represent attractive candidates for disease treatment in human and veterinary research. However, a reliable method for isolation and localization of porcine PMSCs in situ is still uncertain. In this study, we successfully isolated PMSCs from Wuzhishan miniature pig embryos in vitro and also attempted to unravel its fundamental differentiation potential and biological characteristics. The isolated PMSCs, which could be cultured and passaged for at least 15 passages, exhibited a typical fibroblast-like morphology and high proliferative potential...
October 2016: Cell Biology International
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