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CD96

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https://www.readbyqxmd.com/read/29531070/cd96-expression-determines-the-inflammatory-potential-of-il-9-producing-th9-cells
#1
Katarina Stanko, Christina Iwert, Christine Appelt, Katrin Vogt, Julia Schumann, Franziska Janina Strunk, Stefanie Ahrlich, Stephan Schlickeiser, Chiara Romagnani, Karsten Jürchott, Christian Meisel, Gerald Willimsky, Anja A Kühl, Birgit Sawitzki
Recent findings demonstrated proinflammatory functions of interleukin (IL)-9-producing T helper type (Th) 9 cells in the pathogenesis of intestinal bowel diseases (IBDs). However, also antiinflammatory properties have been ascribed to Th9 cells, pointing to a functional heterogeneity. To dissect the specific expression pattern and, especially, diversity of murine antigen-specific Th9 cells, we applied single cell transcription profiling. Th9 cells displayed reduced expression of typical activation markers, such as Cd40 ligand and Cd96 , whereas expression of Cd25 and Cd83 was increased compared with other Th subsets...
March 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29397845/-expressions-of-cd96-and-cd123-and-their-relationship-with-prognosis-of-patients-with-myelodysplastic-syndrome
#2
Xue-Fang Zhang, Shu-Ying Zhang, Hong Zhou, Jia-Wei Feng, Li-Bo Jiang, Yan-Zhang Qu, Heng Guo, Shu-Liang Wang
OBJECTIVE: To explore the relationship between expression of CD96 and CD123 and prognosis of patients with myelodysplastic syndrome(MDS). METHODS: Eight-nine MDS patients(MDS group) and 20 persons without hematologic disease as controls(Control group) were enrolled. The patients were grouped by the risk. All participants received bone marrow biopsy. Mononuclear cells were extracted, CD34+CD38-CD123+ and CD34+CD38-CD96+ cells were counted by using flow cytometry...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29275861/natural-killer-cells-control-tumor-growth-by-sensing-a-growth-factor
#3
Alexander D Barrow, Melissa A Edeling, Vladimir Trifonov, Jingqin Luo, Piyush Goyal, Benjamin Bohl, Jennifer K Bando, Albert H Kim, John Walker, Mary Andahazy, Mattia Bugatti, Laura Melocchi, William Vermi, Daved H Fremont, Sarah Cox, Marina Cella, Christian Schmedt, Marco Colonna
Many tumors produce platelet-derived growth factor (PDGF)-DD, which promotes cellular proliferation, epithelial-mesenchymal transition, stromal reaction, and angiogenesis through autocrine and paracrine PDGFRβ signaling. By screening a secretome library, we found that the human immunoreceptor NKp44, encoded by NCR2 and expressed on natural killer (NK) cells and innate lymphoid cells, recognizes PDGF-DD. PDGF-DD engagement of NKp44 triggered NK cell secretion of interferon gamma (IFN)-γ and tumor necrosis factor alpha (TNF-α) that induced tumor cell growth arrest...
January 25, 2018: Cell
https://www.readbyqxmd.com/read/29251166/expression-of-multiple-leukemic-stem-cell-markers-is-associated-with-poor-prognosis-in-de-novo-acute-myeloid-leukemia
#4
Tomohiro Yabushita, Hironaga Satake, Hayato Maruoka, Mari Morita, Daisuke Katoh, Yoshimitsu Shimomura, Satoshi Yoshioka, Takeshi Morimoto, Takayuki Ishikawa
Leukemic stem cells (LSCs) play a crucial role in chemotherapy resistance in acute myeloid leukemia (AML). Although the association between the expression of individual LSC markers and poor prognosis has been reported, few studies have evaluated the prognostic effect of multiple LSC markers in patients with AML. Herein, we examined three LSC markers (CD25, CD96, and CD123) and the combined effect of their expression on clinical outcome. We retrospectively analyzed 80 adult patients with de novo AML who received intensive chemotherapy...
December 18, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29180478/perioperative-spatiotemporally-coordinated-activation-of-t-and-nk-cells-prevents-recurrence-of-pancreatic-cancer
#5
Jennifer Brooks, Bettina Fleischmann-Mundt, Norman Woller, Julia Niemann, Silvia Ribback, Kristin Peters, Ihsan Ekin Demir, Nina Armbrecht, Guralp O Ceyhan, Michael P Manns, Thomas C Wirth, Stefan Kubicka, Gunter Bernhardt, Mark J Smyth, Diego F Calvisi, Engin Gürlevik, Florian Kühnel
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and disseminating cancer resistant to therapy, including checkpoint immunotherapies, and early tumor resection and (neo)adjuvant chemotherapy fails to improve a poor prognosis. In a transgenic mouse model of resectable PDAC, we investigated the coordinated activation of T and natural killier (NK) cells in addition to gemcitabine chemotherapy to prevent tumor recurrence. Only neoadjuvant, but not adjuvant treatment with a PD-1 antagonist effectively supported chemotherapy and suppressed local tumor recurrence and improved survival involving both NK and T cells...
January 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29133290/cd137-4-1bb-costimulation-modifies-dna-methylation-in-cd8-t-cell-relevant-genes
#6
M Angela Aznar, Sara Labiano, Angel Diaz-Lagares, Carmen Molina, Saray Garasa, Arantza Azpilikueta, Iñaki Etxeberria, Alfonso R Sanchez-Paulete, Alan J Korman, Manel Esteller, Juan Sandoval, Ignacio Melero
CD137 (4-1BB) costimulation imprints long-term changes that instruct the ultimate behavior of T cells that have previously experienced CD137 ligation. Epigenetic changes could provide a suitable mechanism for these long-term consequences. Genome-wide DNA methylation arrays were carried out on human peripheral blood CD8+ T lymphocytes stimulated with agonist monoclonal antibody to CD137, including urelumab, which is in phase I/II clinical trials for cancer immunotherapy. Several genes showed consistent methylation patterns in response to CD137 costimulation, which were confirmed by pyrosequencing in a series of healthy donors...
January 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/28986815/effects-of-compound-zhebei-granule-combined-with-doxorubicin-on-expression-of-specific-surface-antigens-in-mice-with-transplanted-kg-1a-cells
#7
Yu Zhang, Li Hou, Xin-Yi Chen
OBJECTIVE: To investigate the effects of Compound Zhebei Granule (, CZG) combined with doxorubicin hydrochloride (adriamycin, ADM) on specific surface antigens in mice with KG-1a transplanted cells. METHODS: A subcutaneous tumor xenograft model was established by injection of the acute myeloid leukemia cell line KG-1a into the axillary flanks of BALB/c-nude mice. Twenty-four tumor bearing mice were divided into 4 groups according to a random number table, including normal saline control group, ADM group, high-dose CZG group, and mid-dose CZG group, with 6 mice in each group...
October 6, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28979141/genome-scale-analysis-to-identify-prognostic-markers-in-patients-with-early-stage-pancreatic-ductal-adenocarcinoma-after-pancreaticoduodenectomy
#8
Xiwen Liao, Ketuan Huang, Rui Huang, Xiaoguang Liu, Chuangye Han, Long Yu, Tingdong Yu, Chengkun Yang, Xiangkun Wang, Tao Peng
BACKGROUND: Molecular analysis is a promising source of clinically useful prognostic biomarkers. The aim of this investigation was to identify prognostic biomarkers for patients with early-stage pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy. METHODS: An RNA sequencing dataset of PDAC was obtained from The Cancer Genome Atlas. Survival analysis and weighted gene co-expression network analysis were used to investigate the prognostic markers of early-stage PDAC after pancreaticoduodenectomy...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28447034/the-biomarkers-of-leukemia-stem-cells-in-acute-myeloid-leukemia
#9
REVIEW
Yahui Ding, Huier Gao, Quan Zhang
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by morphology and chromosome aberrations with high mortality. Leukemia stem cells (LSCs) in AML played important roles in leukemia initiation, progression, and were considered to be the root of chemotherapeutic drug resistance and disease relapse. The identification and targeting LSCs depended on membrane markers like CD34, CD38, CD123, TIM3, CD25, CD32 and CD96. In addition, the transcription factors were also therapeutic targets in eradicating LSCs, such as histone deacetylases (HDACs), NF-κB, HIF-1α and β-catenin...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28391288/cd33-cd96-and-death-associated-protein-kinase-dapk-expression-are-associated-with-the-survival-rate-and-or-response-to-the-chemotherapy-in-the-patients-with-acute-myeloid-leukemia-aml
#10
Yongfang Jiang, Ping Xu, Dandan Yao, Xi Chen, Haibin Dai
BACKGROUND Leukemia stem cells (LSC) are involved in the incidence, drug resistance, and relapse of leukemia while LSC-related antigen CD33, CD96, and DAPK expression in AML and its prognosis is still unclear. This study explored LSC-related antigens expression in acute myeloid leukemia (AML) and its prognosis. MATERIAL AND METHODS A total of 156 cases of AML patients were enrolled in the experiment. The expression of CD33, CD96, and DAPK in CD34+CD38-CD123+ LSC were tested by flow cytometry. The survival curve was established using the Kaplan-Meier method...
April 9, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28258695/tigit-and-cd96-new-checkpoint-receptor-targets-for-cancer-immunotherapy
#11
REVIEW
William C Dougall, Sema Kurtulus, Mark J Smyth, Ana C Anderson
While therapies targeting the co-inhibitory or immune checkpoint receptors PD-1 and CTLA-4 have shown remarkable success in many cancers, not all patients benefit from these therapies. This has catalyzed enormous interest in the targeting of other immune checkpoint receptors. In this regard, TIGIT and CD96 have recently entered the limelight as novel immune checkpoint receptor targets. TIGIT and CD96 together with the co-stimulatory receptor CD226 form a pathway that is analogous to the CD28/CTLA-4 pathway, in which shared ligands and differential receptor:ligand affinities fine-tune the immune response...
March 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28138156/antibody-dependent-cell-cytotoxicity-immunotherapy-strategies-enhancing-effector-nk-cells
#12
REVIEW
Maria Carmen Ochoa, Luna Minute, Inmaculada Rodriguez, Saray Garasa, Elisabeth Perez-Ruiz, Susana Inogés, Ignacio Melero, Pedro Berraondo
Antibody-dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of cell-to-cell cytolysis executed by immune cells expressing FcRIIIA (CD16A). These effectors include not only natural killer (NK) cells but also other CD16(+) subsets such as monocyte/macrophages, NKT cells or γδ T cells. In cancer therapy, ADCC is exploited by antibodies that selectively recognize proteins on the surface of malignant cells...
April 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27626490/altered-expression-of-cd226-and-cd96-on-natural-killer-cells-in-patients-with-pancreatic-cancer
#13
Yun-Peng Peng, Chun-Hua Xi, Yi Zhu, Ling-Di Yin, Ji-Shu Wei, Jing-Jing Zhang, Xin-Chun Liu, Song Guo, Yue Fu, Yi Miao
The progression of pancreatic cancer (PC) is significantly associated with tumor immune escape, which may be associated with nature killer (NK) cell dysfunction. CD226, CD96, and TIGIT, which share the ligand CD155, play important roles in the regulation of NK cell function. The present study was conducted to investigate the roles of these molecules in NK cells from PC patients. Expression of these molecules on NK cells was detected from samples of 92 pancreatic cancer patients and 40 healthy controls. The expression of CD155 was also evaluated by immunohistochemistry in 88 pancreatic cancer tissues...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27620276/molecular-pathways-targeting-cd96-and-tigit-for-cancer-immunotherapy
#14
REVIEW
Stephen J Blake, William C Dougall, John J Miles, Michele W L Teng, Mark J Smyth
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96- / - mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. TIGIT overexpression has been shown to reduce NK-cell-mediated cytotoxicity. TIGIT is also upregulated on T cells during cancer and chronic viral infection, with expression associated with effector T-cell exhaustion and increased regulatory T-cell suppression...
November 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27503073/inflammatory-monocytes-and-nk-cells-play-a-crucial-role-in-dnam-1-dependent-control-of-cytomegalovirus-infection
#15
Tihana Lenac Rovis, Paola Kucan Brlic, Noa Kaynan, Vanda Juranic Lisnic, Ilija Brizic, Stefan Jordan, Adriana Tomic, Daria Kvestak, Marina Babic, Pinchas Tsukerman, Marco Colonna, Ulrich Koszinowski, Martin Messerle, Ofer Mandelboim, Astrid Krmpotic, Stipan Jonjic
The poliovirus receptor (PVR) is a ubiquitously expressed glycoprotein involved in cellular adhesion and immune response. It engages the activating receptor DNAX accessory molecule (DNAM)-1, the inhibitory receptor TIGIT, and the CD96 receptor with both activating and inhibitory functions. Human cytomegalovirus (HCMV) down-regulates PVR expression, but the significance of this viral function in vivo remains unknown. Here, we demonstrate that mouse CMV (MCMV) also down-regulates the surface PVR. The m20.1 protein of MCMV retains PVR in the endoplasmic reticulum and promotes its degradation...
August 22, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/26910244/antigen-expression-on-a-putative-leukemic-stem-cell-population-and-aml-blast
#16
Swati Garg, Kanjaksha Ghosh, Manisha Madkaikar
A putative leukemic stem cell population in AML defined by Lin-/CD38-/CD34+ is associated with disease prognosis. Antigens that are differentially expressed on normal and leukemic stem cells are known for their potential use in AML prognosis, but their differential expression on blast and pLSC has not been extensively explored in the clinical setting. In the present study, we sought to identify expression level differences of CD44, CD90, CD96, CD123, CD25 and intracellular WT-1; on AML blasts and Lin-/CD38-/CD34+ population in CD34+ AMLs using multi-parametric flow cytometry...
May 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/26823790/differential-loss-of-natural-killer-cell-activity-in-patients-with-acute-myocardial-infarction-and-stable-angina-pectoris
#17
Wenwen Yan, Lin Zhou, Siwan Wen, Qianglin Duan, Feifei Huang, Yu Tang, Xiaohong Liu, Yongyan Chai, Lemin Wang
BACKGROUND: To evaluate the activity of natural killer cells through their inhibitory and activating receptors and quantity in peripheral blood mononuclear cells extracted from patients with acute myocardial infarction, stable angina pectoris and the controls. METHODS: 100 patients with myocardial infarction, 100 with stable angina, and 20 healthy volunteers were recruited into the study. 20 randomly chosen people per group were examined for the whole human genome microarray analysis to detect the gene expressions of all 40 inhibitory and activating natural killer cell receptors...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26787820/suppression-of-metastases-using-a-new-lymphocyte-checkpoint-target-for-cancer-immunotherapy
#18
Stephen J Blake, Kimberley Stannard, Jing Liu, Stacey Allen, Michelle C R Yong, Deepak Mittal, Amelia Roman Aguilera, John J Miles, Viviana P Lutzky, Lucas Ferrari de Andrade, Ludovic Martinet, Marco Colonna, Kazuyoshi Takeda, Florian Kühnel, Engin Gurlevik, Günter Bernhardt, Michele W L Teng, Mark J Smyth
UNLABELLED: CD96 has recently been shown as a negative regulator of mouse natural killer (NK)-cell activity, with Cd96(-/-)mice displaying hyperresponsive NK cells upon immune challenge. In this study, we have demonstrated that blocking CD96 with a monoclonal antibody inhibited experimental metastases in three different tumor models. The antimetastatic activity of anti-CD96 was dependent on NK cells, CD226 (DNAM-1), and IFNγ, but independent of activating Fc receptors. Anti-CD96 was more effective in combination with anti-CTLA-4, anti-PD-1, or doxorubicin chemotherapy...
April 2016: Cancer Discovery
https://www.readbyqxmd.com/read/26768331/screening-of-cd96-and-asxl1-in-11-patients-with-opitz-c-or-bohring-opitz-syndromes
#19
Roser Urreizti, Neus Roca-Ayats, Judith Trepat, Francisco Garcia-Garcia, Alejandro Aleman, Daniela Orteschi, Giuseppe Marangi, Giovanni Neri, John M Opitz, Joaquin Dopazo, Bru Cormand, Lluïsa Vilageliu, Susana Balcells, Daniel Grinberg
Opitz C trigonocephaly (or Opitz C syndrome, OTCS) and Bohring-Opitz syndrome (BOS or C-like syndrome) are two rare genetic disorders with phenotypic overlap. The genetic causes of these diseases are not understood. However, two genes have been associated with OTCS or BOS with dominantly inherited de novo mutations. Whereas CD96 has been related to OTCS (one case) and to BOS (one case), ASXL1 has been related to BOS only (several cases). In this study we analyze CD96 and ASXL1 in a group of 11 affected individuals, including 2 sibs, 10 of them were diagnosed with OTCS, and one had a BOS phenotype...
January 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/26689152/cd155-cd226-interaction-impacts-on-the-generation-of-innate-cd8-thymocytes-by-regulating-inkt-cell-differentiation
#20
Hristo Georgiev, Inga Ravens, Akira Shibuya, Reinhold Förster, Günter Bernhardt
The cell surface receptor CD155 influences a variety of immune processes by binding to its ligands CD226, CD96, or TIGIT. Here, we report that the interaction of CD155 with CD226 in the thymus of BALB/c mice has a dual function. It directly influences the dwell time of memory-like CD8(+) T cells, while it is indirectly involved in generating these cells. It was shown earlier that a massive emergence of memory-like CD8 T cells in thymus crucially depends on abundant IL-4, secreted in steady state by iNKT2 (where iNKT is invariant NKT) cells, a subclass of iNKT cells...
April 2016: European Journal of Immunology
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