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https://www.readbyqxmd.com/read/28199771/thyroid-dysfunction-in-children-with-autism-spectrum-disorder-is-associated-with-folate-receptor-alpha-autoimmune-disorder
#1
Richard E Frye, Rebecca Wynne, Shannon Rose, John Slattery, Leanna Delhey, Marie Tippett, Stephen G Kahler, Sirish C Bennuri, Stepan Melnyk, Jeffrey M Sequeira, Edward Quadros
Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in Autism Spectrum Disorder (ASD). FRAAs disrupt folate transport across the blood-brain barrier by binding to the FRα. Thyroid dysfunction is frequently found in children with ASD. We measured blocking and binding FRAAs and thyroid stimulating hormone (TSH), free T4 (FT4), total T3 (TT3), reverse T3 (rT3), thyroid releasing hormone (TRH) and other metabolites in 87 children with ASD, 84 of whom also underwent behavior and cognition testing and in 42 of whom FRAAs, TSH and FT4 were measured at two time points...
February 15, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28181228/thyrotropin-receptor-gene-expression-in-the-association-between-chronic-spontaneous-urticaria-and-hashimoto-s-thyroiditis
#2
Maria R C Silvares, Maria R P Fortes, Renata de A M L Nascimento, Carlos R Padovani, Hélio A Miot, Célia R Nogueira, Gláucia M F da S Mazeto
BACKGROUND: Chronic spontaneous urticaria (CSU) may be associated with autoimmune thyroid diseases, and the Autologous Serum Skin Test (ASST) is an autoreactivity marker. The thyrotropin (TSH) and TSH receptor (TSHR) could play a role in the pathogenesis of CSU. The aim of this study was to evaluate ASST positivity and TSHR gene expression in healthy skin and ASST wheals in euthyroid women with CSU, with (14 patients) and without (15 patients) Hashimoto's thyroiditis (HT). METHODS: ASST was performed and TSHR gene expression studied in wheals induced by ASST and in healthy skin...
February 8, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28134999/pathogenesis-of-hyperthyroidism
#3
Ishita Singh, Jerome M Hershman
Hyperthyroidism is a form of thyrotoxicosis in which there is excess thyroid hormone synthesis and secretion. Multiple etiologies can lead to a common clinical state of "thyrotoxicosis," which is a consequence of the high thyroid hormone levels and their action on different tissues of the body. The most common cause of thyrotoxicosis is Graves' disease, an autoimmune disorder in which stimulating thyrotropin receptor antibodies bind to thyroid stimulating hormone (TSH) receptors on thyroid cells and cause overproduction of thyroid hormones...
December 6, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/28123504/identification-and-functional-characterization-of-a-novel-thyrotropin-receptor-mutation-v87l-in-a-chinese-woman-with-subclinical-hypothyroidism
#4
Hong-Mei Zhang, Ya-Qin Zhou, Yan Dong, Qing Su
The thyrotropin receptor (TSHR) gene has been defined as a highly mutable gene. Mutations in the TSHR gene result in either gain or loss of the receptor function. Subclinical hypothyroidism (SH) is a clinical condition defined as an elevated serum TSH level associated with normal free thyroxine and free triiodothyronine. Chronic autoimmune thyroiditis is the most frequent cause of subclinical hypothyroidism in adults. In rare cases, a loss-of-function mutation of TSHR is the cause of SH. In the present study, a novel TSHR mutation (V87L; confirmed to be a loss-of-function mutation) was identified in a 59-year-old Chinese woman, as the potential cause of the patient's subclinical hypothyroidism...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28099999/high-level-intrathymic-thyrotropin-receptor-expression-in-thyroiditis-prone-mice-protects-against-the-spontaneous-generation-of-pathogenic-thyrotropin-receptor-autoantibodies
#5
Sandra M McLachlan, Holly A Aliesky, Bianca Banuelos, Sylvie Lesage, Roxanne Collin, Basil Rapoport B
The thyrotropin receptor (TSHR) A-subunit is the autoantigen targeted by pathogenic autoantibodies that cause Graves' hyperthyroidism, a common autoimmune disease in humans. Previously, we reported that pathogenic TSHR antibodies develop spontaneously in thyroiditis-susceptible NOD.H2(h4) mice bearing a human TSHR A-subunit transgene which is expressed at low levels in both the thyroid and thymus (Lo-expressor transgene). The present study tested recent evidence that high intrathymic TSHR expression protects against the development of pathogenic TSHR antibodies in humans...
January 18, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28074218/-autoimmune-diseases-of-the-thyroid-gland
#6
S Allelein, J Feldkamp, M Schott
Autoimmune diseases of the thyroid gland are considered to be the most frequent cause of thyroid gland disorders. Autoimmune thyroid diseases consist of two subgroups: autoimmune thyroiditis (AIT) and Graves' disease. The AIT is the most common human autoimmune disease. Infiltration of the thyroid gland with cytotoxic T‑cells can lead to an initial thyrotoxicosis und during the course to hypothyroidism due to destruction of the thyroid gland. Substitution with Levothyroxine is indicated for manifest hypothyroidism and subclinical hypothyroidism with increased thyroid antibodies with the intention of normalizing the serum thyroid stimulating hormone (TSH)...
January 2017: Der Internist
https://www.readbyqxmd.com/read/28054989/effects-of-long-term-in-vivo-exposure-to-di-2-ethylhexylphthalate-on-thyroid-hormones-and-the-tsh-tshr-signaling-pathways-in-wistar-rats
#7
Xinwen Dong, Jin Dong, Yue Zhao, Jipeng Guo, Zhanju Wang, Mingqi Liu, Yunbo Zhang, Xiaolin Na
Di-(2-ethylhexyl)phthalate (DEHP) was a widely used chemical with human toxicity. Recent in vivo and in vitro studies suggested that DEHP-exposure may be associated with altered serum thyroid hormones (THs) levels, but the underlying molecular mechanisms were largely unknown. To explore the possible molecular mechanisms, 128 Wistar rats were dosed with DEHP by gavage at 0, 150, 300, and 600 mg/kg/day for 3 months (M) and 6 M, respectively. After exposure, expression of genes and proteins in the thyroid, pituitary, and hypothalamus tissues of rats were analyzed by Q-PCR and western blot, while the sera and urine samples were assayed by radioimmunoassay and ELISA...
January 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28025026/hyperdynamic-right-heart-function-in-graves-hyperthyroidism-measured-by-echocardiography-normalises-on-restoration-of-euthyroidism
#8
Stephanie L Teasdale, Warrick J Inder, Michael Stowasser, Tony Stanton
BACKGROUND: Graves' hyperthyroidism commonly causes tachycardia and may result in pulmonary hypertension and high output cardiac failure. There is limited information regarding the effect of treatment on cardiac function measured using modern echocardiographic techniques. METHODS: Eight individuals with Graves' hyperthyroidism, aged 22-64 years, underwent comprehensive transthoracic echocardiography at three time points: before treatment, two weeks after commencement of carbimazole, and at six months or more when euthyroid...
November 19, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28017871/no-mediated-anticontractile-effect-of-the-endothelium-is-abolished-in-coronary-arteries-of-adult-rats-with-antenatal-early-postnatal-hypothyroidism
#9
Dina K Gaynullina, Svetlana I Sofronova, Ekaterina K Selivanova, Anastasia A Shvetsova, Anna A Borzykh, Anna P Sharova, Daria S Kostyunina, Andrey A Martyanov, Olga S Tarasova
INTRODUCTION: Thyroid hormones are essential for proper development of many systems and organs, including circulatory system. Thyroid deficiency during pregnancy may affect the cardiovascular function in children early on and later in adulthood. However, long-term effects of early thyroid deficiency are poorly understood. We hypothesized that antenatal/early postnatal hypothyroidism will influence anticontractile effect of NO in coronary arteries of adult rats. DESIGN AND METHODS: To model antenatal/early postnatal hypothyroidism dams were treated with 6-propyl-2-thiouracil (PTU) in drinking water (0...
December 23, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28009314/hurtle-cells-immunohistochemical-activities-in-hashimoto-thyroiditis-parenchyma
#10
Z Tsagareli, T Kvachadze, E Melikadze, L Metreveli, E Nikobadze, L Gogiashvili
The present study was designed to evaluate the participation and utility of Hǘrtle cells morphological requirment and transformation under Hashimoto autoimmune thyroiditis versus Riedel´s struma. Several markers have been evaluated to detect induced activities of Hǘrtle cells. Study subject - specimens (tissue fragments) collected from TG surgery (thyroidectomy) for mollecular (receptor) diagnosis of Hǘrtle cells activities using routine histological and immunohistochemical samples. 89 cases were selected in Hashimoto thyroiditis diagnosis with Hǘrtle cells history (adenoma and adenomatous grouth of oncocytes)...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27994875/management-of-metastatic-thyroid-cancer-in-pregnancy-risk-and-uncertainty
#11
Christopher W Rowe, Kirsten Murray, Andrew Woods, Sandeep Gupta, Roger Smith, Katie Wynne
: Metastatic thyroid cancer is an uncommon condition to be present at the time of pregnancy, but presents a challenging paradigm of care. Clinicians must balance the competing interests of long-term maternal health, best achieved by iatrogenic hyperthyroidism, regular radioiodine therapy and avoidance of dietary iodine, against the priority to care for the developing foetus, with inevitable compromise. Additionally, epidemiological and cellular data support the role of oestrogen as a growth factor for benign and malignant thyrocytes, although communicating the magnitude of this risk to patients and caregivers, as well as the uncertain impact of any pregnancy on long-term prognosis, remains challenging...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27987211/inhibiting-thyrotropin-insulin-like-growth-factor-1-receptor-crosstalk-to-treat-graves-ophthalmopathy-studies-in-orbital-fibroblasts-in-vitro
#12
Robert F Place, Christine C Krieger, Susanne Neumann, Marvin C Gershengorn
BACKGROUND AND PURPOSE: Crosstalk between thyrotropin (TSH) receptors and insulin-like growth factor 1 (IGF-1) receptors initiated by activation of TSH receptors could be important in the development of Graves' ophthalmopathy (GO). Specifically, TSH receptor activation alone is sufficient to stimulate hyaluronic acid (HA) secretion, a major component of GO, through both IGF-1 receptor-dependent and -independent pathways. Although an anti-IGF-1 receptor antibody is in clinical trials, its effectiveness depends on the relative importance of IGF-1 versus TSH receptor signalling in GO pathogenesis...
February 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27986127/irisin-and-myostatin-levels-in-patients-with-graves-disease
#13
Mehmet Muhittin Yalcin, Mujde Akturk, Yusuf Tohma, Ethem Turgay Cerit, Alev Eroglu Altinova, Emre Arslan, Ilhan Yetkin, Fusun Balos Toruner
BACKGROUND AND AIMS: Skeletal muscle system, which is one of the primary targets for thyroid hormones, has an important role in energy metabolism. Some myokines such as irisin and myostatin have considerable effects on energy metabolism in addition to the musculoskeletal system. Our aim was to investigate circulating irisin and myostatin levels in patients with Graves' Disease (GD). METHODS: This study included 41 patients with GD who were in overt hyperthyroid status and 44 healthy subjects...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27981252/thyroid-hormone-dysfunction-during-pregnancy-a-review
#14
REVIEW
Aynadis Alemu, Betelihem Terefe, Molla Abebe, Belete Biadgo
Thyroid dysfunctions such as hypothyroidism, thyrotoxicosis and thyroid nodules may develop during pregnancy leading to abortion, placental abruptions, preeclampsia, preterm delivery and reduced intellectual function in the offspring. Epidemiological data have shown the significant role of maternal thyroid hormone in fetal neurologic development and maternal health. It has been suggested that the deleterious effects of thyroid dysfunction can also extend beyond pregnancy and delivery to affect neuro-intellectual development in the early life of the child...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27967219/a-survey-of-clinical-practice-patterns-in-management-of-graves-disease-in-the-middle-east-and-north-africa
#15
Salem A Beshyah, Aly B Khalil, Ibrahim H Sherif, Mahmoud M Benbarka, Syed Abbas Raza, Wiam Hussein, Ali S Alzahrani, Asma Chadli
OBJECTIVES: Graves' disease (GD) is commonly seen in endocrine clinical practice. The objective of this study was to evaluate the current diagnosis and management of patient's with GD in the Middle East and North Africa (MENA). METHODOLOGY: An electronic survey on management of GD, using an online questionnaire of a large pool of practicing physicians was performed. Responses from 352 eligible and willing physicians were included in this study. They were mostly endocrinologists (157) and internal medicine physicians (116)...
December 14, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27923251/measurement-of-tsh-receptor-epitope-specific-t-cells-in-graves-disease
#16
S Allelein, A Kuebart, M Haase, T Dringenberg, C Schmid, M Schott, M Ehlers
No abstract text is available yet for this article.
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27923250/clinical-evaluation-of-the-first-automated-assay-for-the-detection-of-stimulating-tsh-receptor-autoantibodies
#17
S Allelein, M Ehlers, S Goretzki, D Hermsen, J Feldkamp, M Haase, T Dringenberg, C Schmid, H Hautzel, M Schott
Until recently, stimulating TSH receptor autoantibodies (sTRAbs) could only be measured by bioassays. A new assay system, which directly detects sTRAb in sera by applying bridge technology, has been established and is now available as automated chemiluminescence (bridge) immunoassay. We evaluated the automated bridge assay in clinical routine and compared it with a conventional automated TRAb assay (competition assay). Altogether, 226 Graves' disease (GD), 57 autoimmune thyroiditis, 74 non-autoimmune nodular goiter and 49 thyroid cancer patients, as well as 41 healthy controls were retrospectively evaluated...
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27921237/structure-and-activation-of-the-tsh-receptor-transmembrane-domain
#18
Ricardo Núñez Miguel, Jane Sanders, Jadwiga Furmaniak, Bernard Rees Smith
PURPOSE: The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves' disease. The TSHR is composed of: a leucine-rich repeat domain (LRD), a hinge region or cleavage domain (CD) and a transmembrane domain (TMD). The binding arrangements between the TSHR LRD and the thyroid-stimulating autoantibody M22 or TSH have become available from the crystal structure of the TSHR LRD-M22 complex and a comparative model of the TSHR LRD in complex with TSH, respectively...
December 2017: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/27916585/perinatal-exposure-to-glyphosate-based-herbicide-alters-the-thyrotrophic-axis-and-causes-thyroid-hormone-homeostasis-imbalance-in-male-rats
#19
Janaina Sena de Souza, Marina Malta Letro Kizys, Rodrigo Rodrigues da Conceição, Gabriel Glebocki, Renata Marino Romano, Tania Maria Ortiga-Carvalho, Gisele Giannocco, Ismael Dale Cotrim Guerreiro da Silva, Magnus Regios Dias da Silva, Marco Aurélio Romano, Maria Izabel Chiamolera
Glyphosate-based herbicides (GBHs) are widely used in agriculture. Recently, several animal and epidemiological studies have been conducted to understand the effects of these chemicals as an endocrine disruptor for the gonadal system. The aim of the present study was to determine whether GBHs could also disrupt the hypothalamic-pituitary-thyroid (HPT) axis. Female pregnant Wistar rats were exposed to a solution containing GBH Roundup(®)Transorb (Monsanto). The animals were divided into three groups (control, 5mg/kg/day or 50mg/kg/day) and exposed from gestation day 18 (GD18) to post-natal day 5 (PND5)...
December 1, 2016: Toxicology
https://www.readbyqxmd.com/read/27913646/critical-differences-between-induced-and-spontaneous-mouse-models-of-graves-disease-with-implications-for-antigen-specific-immunotherapy-in-humans
#20
Basil Rapoport, Bianca Banuelos, Holly A Aliesky, Nicole Hartwig Trier, Sandra M McLachlan
Graves' hyperthyroidism, a common autoimmune disease caused by pathogenic autoantibodies to the thyrotropin (TSH) receptor (TSHR), can be treated but not cured. This single autoantigenic target makes Graves' disease a prime candidate for Ag-specific immunotherapy. Previously, in an induced mouse model, injecting TSHR A-subunit protein attenuated hyperthyroidism by diverting pathogenic TSHR Abs to a nonfunctional variety. In this study, we explored the possibility of a similar diversion in a mouse model that spontaneously develops pathogenic TSHR autoantibodies, NOD...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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