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Adenovirus 36

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https://www.readbyqxmd.com/read/29020589/phase-2-placebo-controlled-trial-of-two-vaccines-to-prevent-ebola-in-liberia
#1
RANDOMIZED CONTROLLED TRIAL
Stephen B Kennedy, Fatorma Bolay, Mark Kieh, Greg Grandits, Moses Badio, Ripley Ballou, Risa Eckes, Mark Feinberg, Dean Follmann, Birgit Grund, Swati Gupta, Lisa Hensley, Elizabeth Higgs, Krisztina Janosko, Melvin Johnson, Francis Kateh, James Logue, Jonathan Marchand, Thomas Monath, Martha Nason, Tolbert Nyenswah, François Roman, Eric Stavale, Julian Wolfson, James D Neaton, H Clifford Lane
BACKGROUND: The safety and efficacy of vaccines to prevent Ebola virus disease (EVD) were unknown when the incidence of EVD was peaking in Liberia. METHODS: We initiated a randomized, placebo-controlled, phase 3 trial of the chimpanzee adenovirus 3 vaccine (ChAd3-EBO-Z) and the recombinant vesicular stomatitis virus vaccine (rVSV∆G-ZEBOV-GP) in Liberia. A phase 2 subtrial was embedded to evaluate safety and immunogenicity. Because the incidence of EVD declined in Liberia, the phase 2 component was expanded and the phase 3 component was eliminated...
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29017084/disseminated-adenovirus-infection-after-allogeneic-stem-cell-transplant-and-the-potential-role-of-brincidofovir-case-series-and-10-year-experience-of-management-in-an-adult-transplant-cohort
#2
Isobel D Ramsay, Charlotte Attwood, Dianne Irish, Paul D Griffiths, Charalampia Kyriakou, David M Lowe
BACKGROUND: Adenovirus infection is a recognized complication following haematopoietic stem cell transplantation. We present a review of our experience of these infections in our transplant cohort over 10 years including 3 patients treated with the novel antiviral brincidofovir. OBJECTIVES: We aimed to describe the presentation, response to treatment and outcomes of adult stem cell transplant patients with disseminated adenovirus infection. STUDY DESIGN: All adult cases of disseminated adenovirus infection following haematopoietic stem cell transplant in our unit between 2005 and 2015 were identified...
October 3, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28980083/adenovirus-infection-in-savanna-chimpanzees-pan-troglodytes-schweinfurthii-in-the-issa-valley-tanzania
#3
Eva Dadáková, Kristýna Brožová, Alex K Piel, Fiona A Stewart, David Modrý, Vladimír Celer, Kristýna Hrazdilová
Adenoviruses are a widespread cause of diverse human infections with recently confirmed zoonotic roots in African great apes. We focused on savanna-dwelling chimpanzees in the Issa Valley (Tanzania), which differ from those from forested sites in many aspects of behavior and ecology. PCR targeting the DNA polymerase gene detected AdV in 36.7% (69/188) of fecal samples. We detected five groups of strains belonging to the species Human mastadenovirus E and two distinct groups within the species Human mastadenovirus C based on partial hexon sequence...
October 4, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28923509/the-complete-genome-sequence-of-human-adenovirus-84-a-highly-recombinant-new-human-mastadenovirus-d-type-with-a-unique-fiber-gene
#4
Győző L Kaján, Adriana E Kajon, Alexis Castillo Pinto, Dániel Bartha, Niklas Arnberg
A novel human adenovirus was isolated from a pediatric case of acute respiratory disease in Panama City, Panama in 2011. The clinical isolate was initially identified as an intertypic recombinant based on hexon and fiber gene sequencing. Based on the analysis of its complete genome sequence, the novel complex recombinant Human mastadenovirus D (HAdV-D) strain was classified into a new HAdV type: HAdV-84, and it was designated Adenovirus D human/PAN/P309886/2011/84[P43H17F84]. HAdV-D types possess usually an ocular or gastrointestinal tropism, and respiratory association is scarcely reported...
September 18, 2017: Virus Research
https://www.readbyqxmd.com/read/28903476/adenoviral-intramyocardial-vegf-d%C3%AE-n%C3%AE-c-gene-transfer-increases-myocardial-perfusion-reserve-in-refractory-angina-patients-a-phase-i-iia-study-with-1-year-follow-up
#5
Juha Hartikainen, Iiro Hassinen, Antti Hedman, Antti Kivelä, Antti Saraste, Juhani Knuuti, Minna Husso, Hanna Mussalo, Marja Hedman, Tuomas T Rissanen, Pyry Toivanen, Tommi Heikura, Joseph L Witztum, Sotirios Tsimikas, Seppo Ylä-Herttuala
Aims: We evaluated for the first time the effects of angiogenic and lymphangiogenic AdVEGF-DΔNΔC gene therapy in patients with refractory angina. Methods and results: Thirty patients were randomized to AdVEGF-DΔNΔC (AdVEGF-D) or placebo (control) groups. Electromechanical NOGA mapping and radiowater PET were used to identify hibernating viable myocardium where treatment was targeted. Safety, severity of symptoms, quality of life, lipoprotein(a) [Lp(a)] and routine clinical chemistry were measured...
September 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28890236/adenovirus-initiative-study-in-epidemiology-advise-results-of-a-multicentric-epidemiology-study-in-spain
#6
A M Muñoz-Hernández, B Duquesroix, J M Benítez-Del-Castillo
OBJECTIVE: Non-interventional, observational, epidemiology study to assess clinical characteristics and frequency of adenovirus conjunctivitis diagnosed by AdenoPlus(®) in patients who presented with signs and symptoms of acute conjunctivitis. Safety aspects during use of the test were analyzed as well. METHOD: This analysis presents the data obtained from the 386 patients enrolled in Spain. Patients had to present with acute signs and symptoms of conjunctivitis ≤7days...
September 7, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28876460/viral-etiology-of-sporadic-cases-of-parotitis-among-children-in-korea-during-2013-2014
#7
Hae J Kang, Sun H Kim, Jae K Chung, Soon W Lee, Seung B Choi, Hye E Eom, Ok Park, Kisoon Kim, Sung S Kim
Recent years have seen a high incidence of mumps, which is generally diagnosed based on clinical features, especially parotitis, without laboratory confirmation in Korea. To better understand the epidemiology of mumps in Korean children, we investigated sporadic suspected mumps cases with parotitis. In total, 237 buccal swabs or throat swabs collected from children with parotitis who had been clinically diagnosed with mumps were tested using real-time PCR for the detection of six viruses (Epstein-Barr virus, Human herpesvirus 6, Mumps virus, Human parainfluenza virus-1, -2, -3, Human adenovirus, Human bocavirus)...
September 6, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28867494/targeting-human-breast-cancer-cells-by-an-oncolytic-adenovirus-using-microrna-targeting-strategy
#8
Mohammad Shayestehpour, Sharareh Moghim, Vahid Salimi, Somayeh Jalilvand, Jila Yavarian, Bizhan Romani, Talat Mokhtari-Azad
MicroRNA-targeting strategy is a promising approach that enables oncolytic viruses to replicate in tumor cells but not in normal cells. In this study, we targeted adenoviral replication toward breast cancer cells by inserting ten complementary binding sites for miR-145-5p downstream of E1A gene. In addition, we evaluated the effect of increasing miR-145 binding sites on inhibition of virus replication. Ad5-control and adenoviruses carrying five or ten copies of miR145-5p target sites (Ad5-5miR145T, Ad5-10miR145T) were generated and inoculated into MDA-MB-453, BT-20, MCF-7 breast cancer cell lines and human mammary epithelial cells (HMEpC)...
September 1, 2017: Virus Research
https://www.readbyqxmd.com/read/28822432/-clinical-analysis-of-children-with-pertussis-and-significance-of-respiratory-virus-detection-in-the-combined-diagnosis
#9
H Huang, L Deng, F Xiao, J Fu, J Deng, F Wang, J Yang
Objective: To analyze the clinical data of children with pertussis and explore the necessity of respiratory virus detection in the combined diagnosis so as to improve the clinician's understanding and standardize the diagnosis and treatment of pertussis in children. Method: Clinical data and laboratory examination of 195 suspected pertussis children between Jan. 2015 and Dec. 2016 in Children's Hospital Affiliated to Capital Institute of Pediatric were analyzed retrospectively. Result: The nasopharyngeal secretions were collected from 195 suspected pertussis children, PCR was employed to detect the nucleic acid of Bordetella pertussis...
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28792686/viral-surveillance-using-pcr-during-treatment-of-aml-and-all
#10
Stephanie B Dixon, Adam Lane, Maureen M O'Brien, Karen C Burns, Jennifer L Mangino, Erin H Breese, Michael J Absalon, John P Perentesis, Christine L Phillips
BACKGROUND: While viral surveillance of cytomegalovirus (CMV), Epstein-Barr virus (EBV), and adenovirus using PCR is routine in patients undergoing hematopoetic stem cell transplant and solid organ transplant, the utility in the nontransplant pediatric leukemia population is unknown. Our institution screens patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) for viral DNAemia by PCR as part of clinical care. PROCEDURE: This retrospective chart review included patients treated for newly diagnosed or relapsed AML or ALL between April 2010 and September 2014...
August 9, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28704319/topical-tacrolimus-for-corneal-subepithelial-infiltrates-secondary-to-adenoviral-keratoconjunctivitis
#11
Silvia Berisa Prado, Ana C Riestra Ayora, Carlos Lisa Fernández, Manuel Chacón Rodríguez, Jesús Merayo-Lloves, José F Alfonso Sánchez
PURPOSE: The objective of this study was to determine the efficacy and safety of topical tacrolimus compounded in the Pharmacy Service for the treatment of subepithelial corneal infiltrates (SEIs) secondary to adenoviral keratoconjunctivitis. METHODS: This retrospective study included patients who had been dispensed topical tacrolimus for the treatment of SEIs during the previous year. Patients were treated with tacrolimus 0.03% eye drops twice daily or tacrolimus 0...
September 2017: Cornea
https://www.readbyqxmd.com/read/28648029/-effects-of-overexpression-of-human-tissue-inhibitor-of-metalloproteinase-1-on-the-inflammatory-response-in-rats-with-myocardial-infarction-and-related-mechanisms
#12
L L Zhao, Y Q Song, Y Zhang, Y Shi, M Ren, S Liu, Y M Mao
Objective: To observe the effects of recombinant adenovirus with human tissue inhibitor of metalloproteinase-1(Ad-hTIMP-1) on the inflammatory response in rats with myocardial infarction (MI) and explore the related mechanisms. Methods: The male Wistar rats were randomly divided into sham-operated group, saline group, Ad-Track group and Ad-hTIMP-1 group according to the random number table (n=8 each group). MI was induced by ligation of the left anterior descending coronary artery and MI rats were injected with saline, Ad-Track and Ad-hTIMP-1, respectively...
June 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28607454/insulin-sparing-and-fungible-effects-of-e4orf1-combined-with-an-adipocyte-targeting-sequence-in-mouse-models-of-type-1-and-type-2-diabetes
#13
I-S Yoon, S Park, R-H Kim, H L Ko, J-H Nam
Obesity impairs glycemic control and causes insulin resistance and type 2 diabetes. Adenovirus 36 (Ad36) infection can increase the uptake of excess glucose from blood into adipocytes by increasing GLUT4 translocation through the Ras-Akt signaling pathway, which bypasses PI3K-Akt-mediated insulin receptor signaling. E4orf1, a viral gene expressed early during Ad36 infection, is responsible for this insulin-sparing effect and may be an alternative target for improving insulin resistance. To deliver the gene to adipocytes only, we connected the adipocyte-targeting sequence (ATS) to the 5' end of E4orf1 (ATS-E4orf1)...
October 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28506838/phylogenomic-analysis-of-the-complete-sequence-of-a-gastroenteritis-associated-cetacean-adenovirus-bottlenose-dolphin-adenovirus-1-reveals-a-high-degree-of-genetic-divergence
#14
Maja Malmberg, Consuelo Rubio-Guerri, Juliette Hayer, Daniel García-Párraga, Elvira Nieto-Pelegrín, Mar Melero, Teresa Álvaro, Mónica Valls, Jose Manuel Sánchez-Vizcaíno, Sándor Belák, Fredrik Granberg
Adenoviruses are common pathogens in vertebrates, infecting a wide range of hosts, but only having rarely been detected and correlated with disease in cetaceans. This article describes the first complete genomic sequence of a cetacean adenovirus, bottlenose dolphin adenovirus 1 (BdAdV-1), detected in captive bottlenose dolphin population (Tursiops truncatus) suffering from self-limiting gastroenteritis. The complete genome sequence of BdAdV-1 was recovered from data generated by high-throughput sequencing and validated by Sanger sequencing...
May 12, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28488368/a-cluster-of-adenovirus-type-b55-infection-in-a-neurosurgical-inpatient-department-of-a-general-hospital-in-guangdong-china
#15
Lina Yi, LiRong Zou, Jing Lu, Min Kang, Yingchao Song, Juan Su, Xin Zhang, LiJun Liang, HanZhong Ni, Changwen Ke, Jie Wu
BACKGROUND: Human adenovirus type 55 is a re-emerging human respiratory pathogen that is associated with several respiratory infections outbreaks in military and school populations. In this study, we describe the first HAdV55-associated hospital outbreak documented in Guangdong, China. METHODS: Active surveillance was conducted in the involved neurosurgical inpatient department. All staff and patients in the involved neurosurgical department were surveyed for any symptoms of fever (≥38°C) and enlarged tonsils during the outbreak period...
July 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28483199/a-prime-boost-immunization-regimen-based-on-a-simian-adenovirus-36-vectored-multi-stage-malaria-vaccine-induces-protective-immunity-in-mice
#16
Jairo A Fonseca, Jessica N McCaffery, Elena Kashentseva, Balwan Singh, Igor P Dmitriev, David T Curiel, Alberto Moreno
Malaria remains a considerable burden on public health. In 2015, the WHO estimates there were 212 million malaria cases causing nearly 429,000 deaths globally. A highly effective malaria vaccine is needed to reduce the burden of this disease. We have developed an experimental vaccine candidate (PyCMP) based on pre-erythrocytic (CSP) and erythrocytic (MSP1) stage antigens derived from the rodent malaria parasite P. yoelii. Our protein-based vaccine construct induces protective antibodies and CD4(+) T cell responses...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28483017/expressions-and-functions-of-kr%C3%A3-ppel-like-factor-5-and-tumor-necrosis-factor-receptor-superfamily-member-11a-in-cervical-cancer-tissues-and-cells
#17
Lingya Chang, Dong Ma, Ou Li, Xinyue Wang, Qi Zhang, Lijie Zhang, Xizhao Yan, Huanyu Zheng
Objective To investigate the expressions of Krüppel like factor 5 (KLF5) and tumor necrosis factor receptor superfamily member 11a (TNFRSF11a) in cervical cancer tissues and their effect on proliferation,migration,and invasion of HeLa cells. Methods Microarray technology was used to detect the mRNA expression of gene in cytocine stimulusin cervical tissues,and the result was verified by real-time fluorescence quantitative polymerase chain reaction. The expressions of KLF5 and TNFRSF11a in cervical tissues were detected by double immunofluorescence staining...
April 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28455139/evaluation-of-adenovirus-36-ad-36-antibody-seropositivity-and-adipokine-levels-in-obese-children
#18
Bekir Kocazeybek, Harika Oyku Dinc, Sevgi Ergin, Suat Saribas, Bahar Taskın Ozcabi, Utku Cizmecigil, Eda Altan, Kevser Atalik, Pelin Yüksel, Zeynep Taner, Asiye Karakullukcu, Serhat Sirekbasan, Nuri Turan, Penbe Cagatay, Nergiz Imamova, Olcay Evliyaoglu, Huseyin Yilmaz
Adenovirus 36 (Ad-36) has recently been suggested as a possible contributor to the current obesity epidemic. The aim of this study was to investigate the prevalence of Ad-36 antibodies in obese children, as well as investigate the role of serum leptin and lipid levels in Ad-36-obesity. Seventy-one obese children and 62 non-obese children were included as the patient group (PG), including the healthy control group (HCG), respectively. Simultaneously, Ad-36 antibodies and adipokine levels were assessed with serum neutralization assays (SNA) and ELISA...
July 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28452009/detection-of-potential-infectious-enteric-viruses-in-fresh-produce-by-rt-qpcr-preceded-by-nuclease-treatment
#19
Elisabet Marti, Monique Ferrary-Américo, Célia Regina Monte Barardi
Foodborne illnesses associated with contaminated fresh produce are a common public health problem and there is an upward trend of outbreaks caused by enteric viruses, especially human noroviruses (HNoVs) and hepatitis A virus (HAV). This study aimed to assess the use of DNase and RNase coupled to qPCR and RT-qPCR, respectively, to detect intact particles of human adenoviruses (HAdVs), HNoV GI and GII and HAV in fresh produce. Different concentrations of DNase and RNase were tested to optimize the degradation of free DNA and RNA from inactivated HAdV and murine norovirus (MNV), respectively...
April 27, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/28444305/dissemination-of-gastroenteric-viruses-in-the-production-of-lettuce-in-developing-countries-a-public-health-concern
#20
Lucia M C Werneck, Carmen B Vieira, Tulio M Fumian, Thalles Borges Caetano, Jarbas Emílio Dos Santos, Fernando César Ferreira, Marcia Maria Pimenta, Marize P Miagostovich
Investigation of major viruses responsible for acute viral gastroenteritis, such as norovirus (NoV), rotavirus species A (RVA) and human adenovirus (HAdV), was conducted in the mountainous region of the state of Rio de Janeiro in a lettuce-producing area. Irrigation water and lettuce samples were collected at different production stages. Viruses were concentrated using an adsorption-elution method and detected by quantitative polymerase chain reaction (qPCR). We detected HAdV in all collection points, although no virus infectivity was shown...
May 1, 2017: FEMS Microbiology Letters
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