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Rational use of medicine

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https://www.readbyqxmd.com/read/28627841/clinical-decision-making-from-theory-to-practice%C3%A2-and-backward
#1
Lionel De Alencastro, Carole Clair, Isabella Locatelli, Mark H Ebell, Nicolas Senn
Being able to analyze all the successive steps of decision making from the first contact with the patient to the final diagnosis is complex because it refers sometimes to intuitive elements proper to each clinician. However, understanding how they integrate probabilities of diseases into their clinical practice and manage diagnostic uncertainties is crucial. This allows a more rational practice of medicine and identifying factors related to the patient, physician or context that may modify the clinical decision making...
May 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28626850/prescribing-indicators-in-primary-health-care-in-belo-horizonte-brazil-associated-factors
#2
Marina Guimarães Lima, Kátia Reis Dutra, Ursula Carolina Morais Martins
Background The prescription is one of the factors that influences rational use of medicines. The evaluation of prescribing indicators should contribute to organization of primary health care services. Objective The aim of this study was to evaluate prescribing indicators and associated factors in primary health care in the northeast health district, Belo Horizonte, Brazil. Setting Twenty primary health care units in the Northeast Health District, Belo Horizonte, Brazil. Method The study was cross sectional...
June 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28622708/pharmacokinetic-comparison-of-two-phenolic-acids-after-oral-administration-of-typhae-pollen-to-normal-rats-and-rats-with-acute-cold-blood-stasis
#3
Yingni Pan, Wenjie Zhang, Wei Zhang, Xuewei Bai, Shumeng Ren, Jiang Zheng, Dongmei Wang, Xiaoqiu Liu
Typhae Pollen (TP), dried pollen of Typha angustifolia L., Typha orientalis Presl or other plants of the same genus (Typhaeceae), has effect of activating the circulation to cure blood stasis in traditional Chinese Medicine (TCM). The purpose of this study was to set up an ultra-high performance liquid chromatography method that could determine p-hydroxybenzoic acid and vanillic acid simultaneously in rat plasma, and to compare their pharmacokinetics in normal rats and rats with acute cold blood stasis, and further to investigate the influence of different dosages of oral administration...
June 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28618993/new-perspectives-on-biomedical-applications-of-iron-oxide-nanoparticles
#4
Massimiliano Magro, Davide Baratella, Emanuela Bonaiuto, Jessica de Almeida Roger, Fabio Vianello
Iron oxide nanomaterials are considered promising tools for improved therapeutic efficacy and diagnostic applications in biomedicine. Accordingly, engineered iron oxide nanomaterials are increasingly proposed in biomedicine, and the interdisciplinary researches involving physics, chemistry, biology (nanotechnology) and medicine have led to exciting developments in the last decades. The progresses of the development of magnetic nanoparticles with tailored physico-chemical and surface properties produced a variety of clinically relevant applications, spanning from magnetic resonance imaging (MRI), drug delivery, magnetic hyperthermia, to in vitro diagnostics...
June 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28616960/functional-build-in-template-directed-siliceous-fluorescent-supramolecular-vesicles-as-diagnostics
#5
Jie Li, Kaerdun Liu, Hengyu Chen, Ruoyan Li, Markus Drechsler, Fan Bai, Jianbin Huang, Ben Zhong Tang, Yun Yan
Functional template directed synthesis of hybrid siliceous fluorescent vesicle (HSFV) is fabricated by using fluorescent vesicle as a build-in template. The template vesicle is the ionic self-assembly of an aggregation-induced emission (AIE) fluorogen. Upon depositing folic acid modified silica shell on its surface, the obtained HSFVs display low cytotoxicity, significant fluorescence and targeted drug delivery toward cancer cells. Furthermore, the wall-thickness of the HSFVs can be controlled via altered concentration of silica source...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28606807/recent-pharmaceutical-evidence-on-the-compatibility-rationality-of-traditional-chinese-medicine
#6
REVIEW
Miaomiao Zhou, Yanlong Hong, Xiao Lin, Lan Shen, Yi Feng
ETHNOPHARMACOLOGICAL RELEVANCE: Chinese herbs have been used in China for thousands of years and are also becoming popular in Western medicine. Formulae of traditional Chinese medicine (TCM), which contain two or more herbs, can often obtain better curative efficacies and fewer side effects than single herbs. Though there are many reports on pharmaceutics, pharmacokinetics, and pharmacodynamics of TCM, there remains a serious lack of summarization and systemic analyses of these reported data to help uncover the compatibility rationale of TCM...
June 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28606198/clinical-information-transfer-between-ems-staff-and-emergency-medicine-assistants-during-handover-of-trauma-patients
#7
Seyedeh Almas Fahim Yegane, Ali Shahrami, Hamid Reza Hatamabadi, Seyed-Mostafa Hosseini-Zijoud
Introduction Clinical handover by Emergency Medical Services (EMS) staff, as the first people who have contact with trauma patients, in the emergency department (ED), is very important. Therefore, effective communication to transfer clinical information about patients in a concise, rational, clear, and time-bound manner is essential. In Iran, the transfer of necessary information in clinical handover in EDs was carried out orally and without following standard instructions. This study aimed to audit the current clinical handover according to the Identify, Situation, Background, Assessment, and Recommendation (ISBAR) tool and survey the effect of training the ISBAR tool to Emergency Medicine Assistants (EMAs) and EMS staff on improvement of the clinical handover of patients to the ED...
June 13, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28606186/comparison-of-chemical-profiles-between-the-root-and-aerial-parts-from-three-bupleurum-species-based-on-a-uhplc-qtof-ms-metabolomics-approach
#8
Lin Zhu, Zhi-Tao Liang, Tao Yi, Yue Ma, Zhong-Zhen Zhao, Bao-Lin Guo, Jian-Ye Zhang, Hu-Biao Chen
BACKGROUND: Bupleuri Radix (Chaihu) represents one of the most successful and widely used herbal medicines in Asia for the treatment of many diseases such as inflammatory disorders and infectious diseases over the past 2000 years. In the Chinese Pharmacopoeia, Chaihu is recorded as the dried roots of Bupleurum chinense DC. and B. scorzonerifolium Willd. (Umbelliferae). However, the widespread demand for the herb has tended to far outstrip the supply. Whether the aerial parts, which account for 70 ~ 85% of the dry weights of Bupleurum species, could be used as an alternative for the root has become an important scientific issue for the sustainable utilization of Bupleurum species...
June 12, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28596645/platelet-derived-biomaterials-for-therapeutic-use-review-of-technical-aspects
#9
REVIEW
Satyam Arora, Naveen Agnihotri
Whole blood is composed of both cellular and plasma components, providing a rich source of therapeutic products. Of late, platelet derived biomaterial (platelet rich plasma) consisting of plasma proteins and platelets are increasingly being used for various indications. Protocols for preparation and nomenclature of this biomaterial vary widely amongst authors and are often not well defined. Additionally, they are not uniformly documented in the literature, making results difficult to compare or replicate. In this paper we review the evolution and type of these products available for clinical use...
June 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28579004/sirna-delivery-system-based-on-magnetic-nanovectors-characterization-and-stability-evaluation
#10
Mohammed Abdelrahman, Laurence Douziech Eyrolles, Suad Y Alkarib, Katel Hervé-Aubert, Sanaa Ben Djemaa, Hervé Marchais, Igor Chourpa, Stephanie David
Gene therapy and particularly small interfering RNA (siRNA) is a promising therapeutic method for treatment of various human diseases, especially cancer. However the lack of an ideal delivery system limits its clinical applications. Effective anticancer drug development represents the key for translation of research advances into medicines. Previously we reported, the optimization of magnetic siRNA nanovectors (MSN) formulation based on superparamagnetic iron oxide nanoparticles (SPION) and chitosan for systemic administration...
June 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28576250/patient-safety-in-burn-care-application-of-evidence-based-medicine-to-improve-outcomes
#11
REVIEW
Elizabeth L Dale, Charles Scott Hultman
This article reviews 5 areas in burn care that increasingly use evidence-based medicine to optimize quality and safety: resuscitation protocols, transfusion practices, vascular access, venous thromboembolic prophylaxis, and rational use of antibiotics.
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28574393/-rational-use-apricot-gum-gummi-armeniacae-in-republic-of-armenia
#12
N Chichoyan
Till nowadays the sources of gums of Armenian flora are remaining unutilized because of absence of resoursological and phytochemical research as well as standards corresponding. Amongst the camed-bearing trees of the flora of Armenia (apricot, peach, plum, almond) and the other families representatives (eleagnus, tragakant) the apricot trees (Armeniaca vulgaris Lam.) became an object of our great interests, considering its being as the most important cultivating fruit-bearing trees in Armenia and the fact, that they cover significant areas in the Ararat valley, Kotayk, Aragatsotn and the footings of the Vayk region...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28571162/a-qualitative-study-of-knowledge-attitude-and-practice-towards-pharmacovigilance-among-doctors-and-nursing-staff-in-a-tertiary-care-hospital-in-india
#13
Bharat Gajjar, Nazima Mirza, Alpa Gor, Malkesh Mistry, Nishal Shah
INTRODUCTION: Pharmacovigilance is the branch of science that deals with the detection, assessment, understanding and prevention of adverse reactions to medicines (i.e., adverse drug reactions or ADRs). The purpose of pharmacovigilance is to implement the safe and rational use of medicines, which ultimately helps in improving patient care. AIM: To investigate the Knowledge, Attitude And Practice (KAP) of clinicians, residents and nursing staff towards pharmacovigilance and Adverse Drug Events (ADE) reporting and to identify possible reasons for underreporting and to receive suggestions to improve the ADE reporting...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28567371/the-use-of-finite-element-analyses-to-design-and-fabricate-three-dimensional-scaffolds-for-skeletal-tissue-engineering
#14
REVIEW
Wim J Hendrikson, Clemens A van Blitterswijk, Jeroen Rouwkema, Lorenzo Moroni
Computational modeling has been increasingly applied to the field of tissue engineering and regenerative medicine. Where in early days computational models were used to better understand the biomechanical requirements of targeted tissues to be regenerated, recently, more and more models are formulated to combine such biomechanical requirements with cell fate predictions to aid in the design of functional three-dimensional scaffolds. In this review, we highlight how computational modeling has been used to understand the mechanisms behind tissue formation and can be used for more rational and biomimetic scaffold-based tissue regeneration strategies...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28562078/alpha-glucosidase-inhibitory-activity-of-ethanol-extract-fractions-and-purified-compounds-from-the-wood-of-albizia-myriophylla
#15
Nantiya Joycharat, Papawarin Issarachote, Chonlatid Sontimuang, Supayang Piyawan Voravuthikunchai
Albizia myriophylla Benth. is a medicinal herb which is used as a traditional remedy for various ailments including diabetes in Thailand. In our continued investigation of the biological activity of A. myriophylla, the ethanol extract, fractions and the isolated compounds from the wood of this plant were evaluated for in vitro α-glucosidase inhibition using spectrophotometric method. The plant ethanol extract and its different fractions possessed α-glucosidase inhibitory activity in a concentration-dependent manner...
May 31, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28558875/characterization-and-quantitation-of-aristolochic-acid-analogs-in-different-parts-of-aristolochiae-fructus-using-uhplc-q-tof-ms-and-uhplc-qqq-ms
#16
Wen-Wen Mao, Wen Gao, Zhi-Tao Liang, Ping Li, Zhong-Zhen Zhao, Hui-Jun Li
Aristolochiae Fructus, a Chinese herbal medicine derived from the fruit of Aristolochia contorta Bge., contains nephrotoxic aristolochic acid analogues (AAAs). According to ancient medical texts, various medicinal parts of the fruit of A. contorta were ever used. In order to reveal which part could be safely and effectively used, it is necessary to analyze the chemical profiles of different medicinal parts. Herein we compared the chemical compositions and determined aristolochic acid I (AA-I) and aristolochic acid II (AA-II) in the four parts viz...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28555527/mapping-the-collaterome-for-precision-cerebrovascular-health-theranostics-in-the-continuum-of-stroke-and-dementia
#17
David S Liebeskind
Precision cerebrovascular health or individualized long-term preservation of the brain and associated blood vessels, is predicated on understanding, diagnosing, and tailoring therapies for people at risk of ischemic injury associated with stroke and vascular dementia. The associated imaging patterns are sculpted by the protective effect of the collaterome, the innate compensatory ability of the brain and vasculature to offset hypoperfusion when antegrade or normal arterial inflow pathways are compromised. Theranostics or rational and synchronous use of diagnostic studies in tandem with specific therapies to optimally guide patient outcomes in ischemic brain disorders may capitalize on the pivotal role of the collaterome...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28545375/natural-product-gossypol-and-its-derivatives-in-precision-cancer-medicine
#18
Yun Zeng, Jingwen Ma, Liang Xu, Daocheng Wu
Gossypol, a natural product extracted from the seed, roots, and stem of cotton, was initially used as a male contraceptive but was subsequently investigated as a novel antitumor agent. This review depicts the current status of gossypol and its derivatives as novel antitumor agents as well as presents their preparation and characteristics, especially of some gossypol Schiff bases, through quantitative and structural analyses. The main attractive target sites of gossypol and its derivatives are Bcl-2 family proteins containing the anti-apoptosis proteins Bcl-2 and Bcl-XL...
May 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28544541/identification-and-analysis-of-chemical-constituents-and-rat-serum-metabolites-in-suan-zao-ren-granule-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-combined-with-multiple-data-processing-approaches
#19
Yiyang Du, Bosai He, Qing Li, Jiao He, Di Wang, Kaishun Bi
Suan-Zao-Ren granule is widely used to treat insomnia in China. However, because of the complexity and diversity of the chemical compositions in traditional Chinese medicine formula, the comprehensive analysis of constituents in vitro and in vivo are rather difficult. In our study, an ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry and the PeakView® software, which uses multiple data processing approaches including product ion filter, neutral loss filter and mass defect filter, method was developed to characterize the ingredients and rat serum metabolites in Suan-Zao-Ren granule...
May 24, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28539738/the-mealiness-and-quality-of-herbal-medicine-licorice-for-example
#20
Xueying Liu, Weilong Hou, Deqiang Dou
BACKGROUND: The morphological identification is an effective and simple quality evaluation method in Chinese drugs, and the traits of mealiness and color were widely used in the commercial market of Chinese drugs. OBJECTIVE: The objective of this study was to explore the correlation between mealiness of herbal drugs and its quality; licorice was selected as an example. MATERIALS AND METHODS: The mealiness of licorice was graded by its weight; meanwhile, the content of glycyrrhizic acid and liquiritin was determined by high-performance liquid chromatography-diode-array detection method; the content of polysaccharides, soluble sugars, pectin, total starch, amylose, and amylopectin was measured by colorimetric method; and the number and diameter of starch granule were observed by microscope...
April 2017: Pharmacognosy Research
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