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https://www.readbyqxmd.com/read/28936853/-classics-textual-research-and-using-situation-investigation-of-tibetan-medicine-zha-xun
#1
Yun Cao, Rui Gu, Ming-Ming Zhao, Yu-Ying Ma, Shi-Hong Zhong, Jian Rang, Peng Mi
In this article the classics textual research to the origin of "Zha-xun" was carried out, the ethnobotanical research methods, the origin of visits, key informant interviews, sample collection and textual research were applied in the research. The results showed that the hypothesis of Zha-xun"s origin mainly included "source of mine", "source of feces", "source of monkey menstrual blood" in China. There were "source of fossil", "source of the plant secretion" abroad. The authors had interviewed the villagers at origin, herbalists, Tibetan doctors, herb dealers, foreign scholars for a total of 18 people, and collecting 45 batches medicinal materials...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936834/-advances-of-toxicity-evaluation-of-cinnabar-and-compatibility-necessity-analysis
#2
REVIEW
Tong Ding, Jiao-Yang Luo, Xu Han, Shi-Hai Yang, Rui-Chao Lin, Mei-Hua Yang
Cinnabars are widely used in the clinic and shows unique efficacy, and it has been used in treating diseases for thousands of years either single-use or combination with other traditional Chinese medicines. Cinnabar mainly contains mercury, which displays obvious hepatotoxicity and nephrotoxicity. The safety of cinnabar and its rational use caused extensive attention. However, there are some misunderstanding that cinnabar shows equivalent toxicity to the toxicity of mercury compounds such as mercuric chloride and methylmercury in safety evaluation of cinnabar, which in our view exaggerates the toxicity...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936830/-registration-of-30-026-cases-of-shenqi-fuzheng-injection-combined-with-other-drugs-in-real-world
#3
Lian-Xin Wang, Yan-Ming Xie, Qing-Hua Ai, Qian Feng
Prospective, multi-center, large-sample and registered design was used to analyze the drug combination features of Shenqi Fuzheng injection in the real world clinical application, and comprehend the drug combination in the real world. A total of 30 026 patients with the use of Shenqi Fuzheng injection were registered, where the chemical drugs were used for 57 436 times (accounting for 82.76%), and the Chinese patent medicines were used for 11 962 times (accounting for 17.24%), mainly including anti-acid drugs and anti-ulcer drugs, nutritional agent, immune enhancement agent, etc...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28933856/understanding-the-coordination-modes-of-cu-acac-2-imidazole-n-1-2-adducts-by-epr-endor-hyscore-and-dft-analysis
#4
Nadine Ritterskamp, Katherine Sharples, Emma Richards, Andrea Folli, Mario Chiesa, James A Platts, Damien M Murphy
The interaction of imidazole with a [Cu(acac)2] complex was studied using electron paramagnetic resonance (EPR), electron nuclear double resonance (ENDOR), hyperfine sublevel correlation spectroscopy (HYSCORE), and density functional theory (DFT). At low Im ratios (Cu:Im 1:10), a 5-coordinate [Cu(acac)2Imn=1] monoadduct is formed in frozen solution with the spin Hamiltonian parameters g1 = 2.063, g2 = 2.063, g3 = 2.307, A1 = 26, A2 = 15, and A3 = 472 MHz with Im coordinating along the axial direction. At higher Im concentrations (Cu:Im 1:50), a 6-coordinate [Cu(acac)2Imn=2] bis-adduct is formed with the spin Hamiltonian parameters g1 = 2...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28929649/-rationality-of-commodity-criteria-and-traditional-breeding-of-polygala-tenuifolia-based-on-agronomic-traits-and-determination-of-chemical-components
#5
Dan-Dan Wang, Lu Bai, Xiao-Shuang Xu, Fu-Sheng Zhang, Jie Xing, Jin-Ping Jia, Hong-Ling Tian, Xue-Mei Qin
The agronomic traits (plant height, root diameter, root length, first lateral root height, lateral root amount, root weight) of 18 Polygala tenuifolia samples with different agronomic traits were analyzed, respectively. HPLC was used to analyze three main characteristic components including tenuifolin, polygalaxanthone Ⅲ, and 3,6'-disinapoyl sucrose. At last, the correlation between six agronomic traits and three main characteristic components were analyzed by scatter plot. We found no significant correlation between root diameter and three main characteristic components...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28922959/compliance-to-the-primary-health-care-treatment-guidelines-and-the-essential-medicines-list-in-the-management-of-sexually-transmitted-infections-in-correctional-centres-in-south-africa-findings-and-implications
#6
Tammy B Matsitse, Elvera Helberg, Johanna C Meyer, Brian Godman, Amos Massele, Natalie Schellack
BACKGROUND: The emergence of antimicrobial resistance (AMR) is a global concern and a growing health crisis. Additionally, evidence has shown that non-compliance to treatment guidelines, especially in the management of communicable diseases such as sexually transmitted infections (STIs), has the potential of further enhancing AMR rates. Data on the extent of these challenges in Primary Health Care (PHC) facilities in correctional centres in South Africa (SA) is limited. Hence this study was conducted to determine the level of compliance with the 2008 PHC Standard Treatment Guidelines and Essential Medicines List (PHC STGs/EML) in the management of STIs, and to identify potential factors contributing to the compliance and non-compliance to guide future strategies...
September 19, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28916961/practical-computational-toolkits-for-dendrimers-and-dendrons-structure-design
#7
Nuno Martinho, Liana C Silva, Helena F Florindo, Steve Brocchini, Teresa Barata, Mire Zloh
Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and structural determination, which can be overcome by judicious use of molecular modelling and molecular simulations. A major difficulty to utilise in silico studies to design dendrimers lies in the laborious generation of their structures. Current modelling tools utilise automated assembly of simpler dendrimers or the inefficient manual assembly of monomer precursors to generate more complicated dendrimer structures...
September 15, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28914436/chinese-and-indian-women-s-experience-with-alternative-medications-for-menopause-related-symptoms-a-qualitative-analysis
#8
Saw Ohn Mar, Fatehpal Singh Malhi, Syed Hamid Syed Rahim, Myint Myint Soe
OBJECTIVE: To explore women's rationalization for using alternative medications, their experience and view on safety of long-term use. METHODS: Two focus group discussions, involving 5 participants each for Chinese and Indian groups, were conducted separately. Participant's personal information was collected anonymously. The discussion covered 5 areas: determinants for taking medications; reason for choosing alternative medications rather than hormone replacement therapy (HRT); how these medications help them; their view on cost-effectiveness and concerns over long-term use...
September 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28911247/metabolic-pathways-and-pharmacokinetics-of-natural-medicines-with-low-permeability
#9
Mei Zeng, Lan Yang, Dan He, Yao Li, Mingxin Shi, Jingqing Zhang
Drug metabolism plays an important role in the drug disposal process. Differences in pharmacokinetics among individuals are the basis for personalized medicine. Natural medicines, formed by long-term evolution of nature, prioritize the action of a target protein with a drug. Natural medicines are valued for structural diversity, low toxicity, low cost, and definite biological activities. Metabolic pathway and pharmacokinetic research of natural medicines is highly beneficial for clinical dose adjustment and the development of personalized medicine...
September 14, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28905855/new-insights-into-the-epigenetics-of-inflammatory-rheumatic-diseases
#10
REVIEW
Esteban Ballestar, Tianlu Li
Over the past decade, awareness of the importance of epigenetic alterations in the pathogenesis of rheumatic diseases has grown in parallel with a general recognition of the fundamental role of epigenetics in the regulation of gene expression. Large-scale efforts to generate genome-wide maps of epigenetic modifications in different cell types, as well as in physiological and pathological contexts, illustrate the increasing recognition of the relevance of epigenetics. To date, although several reports have demonstrated the occurrence of epigenetic alterations in a wide range of inflammatory rheumatic conditions, epigenomic information is rarely used in a clinical setting...
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28882325/antimicrobial-stewardship-programme-in-critical-care-medicine-a-prospective-interventional-study
#11
J Ruiz, P Ramirez, M Gordon, E Villarreal, J Frasquet, J L Poveda-Andres, M Salavert-Lletí, A Catellanos
OBJECTIVE: Hospital antimicrobial stewardship programmes have achieved savings and a more rational use of antimicrobial treatments in general wards. The purpose of this report is to evaluate the experience of an antimicrobial stewardship programme in an intensive care unit (ICU). DESIGN: Prospective interventional, before-and-after study. SCOPE: 24-bed medical ICU in a tertiary hospital. INTERVENTION: Prospective audit and feedback antimicrobial stewardship programme...
September 4, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28877177/an-in-vitro-diagnostic-certified-point-of-care-single-nucleotide-test-for-il28b-polymorphisms
#12
Darragh Duffy, Estelle Mottez, Shaun Ainsworth, Tan-Phuc Buivan, Aurelie Baudin, Muriel Vray, Ben Reed, Arnaud Fontanet, Alexandra Rohel, Ventzislava Petrov-Sanchez, Laurent Abel, Ioannis Theodorou, Gino Miele, Stanislas Pol, Matthew L Albert
Numerous genetic polymorphisms have been identified as associated with disease or treatment outcome, but the routine implementation of genotyping into actionable medical care remains limited. Point-of-care (PoC) technologies enable rapid and real-time treatment decisions, with great potential for extending molecular diagnostic approaches to settings with limited medical infrastructure (e.g., CLIA certified diagnostic laboratories). With respect to resource-limited settings, there is a need for simple devices to implement biomarker guided treatment strategies...
2017: PloS One
https://www.readbyqxmd.com/read/28872402/overall-and-leisure-time-physical-activity-among-brazilian-adults-national-survey-based-on-the-global-physical-activity-questionnaire
#13
Inacio Crochemore Mohnsam da Silva, Grégore I Mielke, Andréa D Bertoldi, Paulo Arrais, Vera L Luiza, Sotero S Mengue, Pedro C Hallal
BACKGROUND: To describe overall physical activity prevalence measured by the Global Physical Activity Questionnaire (GPAQ), as well as inequalities in leisure-time physical activity among Brazilian adults (15+ years) Methods: Data from the Brazilian Survey on Medicine Access, Utilization and Rational Use of Medicines were analyzed. The study was carried out between September 2013 and January 2014. Physical activity was measured through GPAQ and classified according to the recommendations of the World Health Organization...
September 5, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28867241/targeted-nanomedicine-for-cancer-therapeutics-towards-precision-medicine-overcoming-drug-resistance
#14
Maya Bar-Zeev, Yoav D Livney, Yehuda G Assaraf
Intrinsic anticancer drug resistance appearing prior to chemotherapy as well as acquired resistance due to drug treatment, remain the dominant impediments towards curative cancer therapy. Hence, novel targeted strategies to overcome cancer drug resistance constitute a key aim of cancer research. In this respect, targeted nanomedicine offers innovative therapeutic strategies to overcome the various limitations of conventional chemotherapy, enabling enhanced selectivity, early and more precise cancer diagnosis, individualized treatment as well as overcoming of drug resistance, including multidrug resistance (MDR)...
March 2017: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/28856890/cyclic-dipeptide-based-ambidextrous-supergelators-minimalistic-rational-design-structure-gelation-studies-and-in-situ-hydrogelation
#15
Shivaprasad Manchineella, N Arul Murugan, Thimmaiah Govindaraju
Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic properties. Intermolecular hydrogen bonding, the major driving force for gelation was evaluated using temperature-dependent nuclear magnetic resonance (NMR) spectroscopy. The contribution of attractive van der Waals interaction of tBoc group in driving CDP gelation was ascertained using β-cyclodextrin (β-CD)-adamantane carboxylic acid (AC)-based host-guest gelation and (1)H NMR studies...
September 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28854906/flavonoids-from-tetracera-indica-merr-induce-adipogenesis-and-exert-glucose-uptake-activities-in-3t3-l1-adipocyte-cells
#16
Md Mahmudul Hasan, Qamar Uddin Ahmed, Siti Zaiton Mat Soad, Jalifah Latip, Muhammad Taher, Tengku Muhamad Faris Syafiq, Murni Nazira Sarian, Alhassan Muhammad Alhassan, Zainul Amiruddin Zakaria
BACKGROUND: Tetracera indica Merr. (Family: Dilleniaceae), known to the Malay as 'Mempelas paya', is one of the medicinal plants used in the treatment of diabetes in Malaysia. However, no proper scientific study has been carried out to verify the traditional claim of T. indica as an antidiabetic agent. Hence, the aims of the present study were to determine the in vitro antidiabetic potential of the T. indica stems ethanol extract, subfractions and isolated compounds. METHODS: The ethanol extract and its subfractions, and isolated compounds from T...
August 30, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28852629/essential-medicine-utilization-and-situation-in-selected-ten-developing-countries-a-compendious-audit
#17
REVIEW
Mainul Haque
Medicine improves the quality of life and increases mean age of human beings as it fights against diseases. Accessibility to medicines is the fundamental right of every person. The principle of the essential medicines (EMs) is that a limited number of availability of medicine will promote to a better supply chain and rational prescribing to the rural and remote health centers for any developing countries. Furthermore, it was also expected that this concept will also ensure better procurement policy at lower costs, more in amount, with easier storage...
July 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28846018/investigating-the-effect-of-syrian-refugees-on-the-pharmaceutical-sector-in-jordan
#18
Amirah Daher, Ibrahim Alabbadi
The aim of this study was to investigate the effect of Syrian refugees on the pharmaceutical sector in Jordan. Based on a standardized methodology developed by the WHO, Level II Facility (2009) structured questionnaires (including: medicine access [availability, affordability and geographical accessibility], quality, and rational use of medicines) were used to investigate the effect of Syrian refugees influx on the pharmaceutical sector in Jordan. Lists of essential medicines (N = 50) were included in the survey forms...
August 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28840614/pharmacological-evaluation-of-gut-modulatory-and-bronchodilator-activities-of-achyranthes-aspera-linn
#19
Hafiz Muhammad Abdur Rahman, Samra Bashir, Safur Rehman Mandukhail, Sohaib Huda, Anwarul Hassan Gilani
Achyranthes aspera L. is traditionally used to relieve constipation, diarrhea, and asthma. Its crude extract (Aa.Cr) was evaluated through in vivo and ex vivo experiments to rationalize these medicinal uses of A. aspera and to provide their scientific basis. Aa.Cr, at 3 and 10 mg/kg, increased fecal output, similar to castor oil, whereas at 30, 100, 300, and 700 mg/kg, it protected against castor oil-induced diarrhea in mice when administered orally. Aa.Cr caused spasmogenic effect on rabbit jejunum and guinea pig ileum preparations, which was partially inhibited by atropine while completely blocked by cyproheptadine preincubation...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28836365/use-of-antidepressants-in-dentistry-a-systematic-review
#20
REVIEW
Patrícia Azevedo Lino, Carolina de Castro Martins, Gabriel Ferreira Pessoa Carvalho Miranda, Maria Elisa de Souza E Silva, Mauro Henrique Nogueira Guimarães de Abreu
OBJECTIVE: Previous research has suggested that antidepressants can be used in oral health care. The aim of this systematic review was to search for scientific evidence of the efficacy of the use of antidepressants in dentistry. MATERIALS AND METHODS: The clinical question was as follows (PICO Question): dentistry patients (Patients); antidepressants (Intervention); no use or placebo or other drug (Comparison); efficacy in oral health problems (Outcome). An electronic search was conducted in seven databases, as well as a manual search without restriction regarding language and date of publication...
August 24, 2017: Oral Diseases
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