Marko Stojanović, Mirjana B Čolović, Jovana Lalatović, Aleksandra Milosavljević, Nada D Savić, Kilian Declerck, Branimir Radosavljević, Mila Ćetković, Tamara Kravić-Stevović, Tatjana N Parac-Vogt, Danijela Krstić
Polyoxotungstate nanoclusters have recently emerged as promising contrast agents for computed tomography (CT). In order to evaluate their clinical potential, in this study, we evaluated the in vitro CT imaging properties, potential toxic effects in vivo, and tissue distribution of monolacunary Wells-Dawson polyoxometalate, α2 -K10 P2 W17 O61 . 20H2 O (mono-WD POM). Mono-WD POM showed superior X-ray attenuation compared to other tungsten-containing nanoclusters (its parent WD-POM and Keggin POM) and the standard iodine-based contrast agent (iohexol)...
February 22, 2024: International Journal of Molecular Sciences