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M Najjar, H Jebali, R Kheder, M Khaddar, L Raïs, L Ben Fatma, W Smaoui, M Krid, F Ben Moussa, S Beji, K Zouaghi
OBJECTIFS: Au cours du lupus érythémateux systémique (LES), l'hypertension artérielle (HTA) est une manifestation fréquente de mécanisme multifactoriel. On se propose de déterminer le profil anatomo-clinique de l'HTA chez les patients ayant une néphropathie lupique (NL). MéTHODES: Il s'agit d'une étude rétrospective portant sur 42 patients suivis pour LES colligés sur une période de 7 ans (2007-2015). Nous avons étudié leurs caractéristiques cliniques, biologiques, histologiques et évolutives...
December 2015: Annales de Cardiologie et D'angéiologie
A A Soliman, R Csorba, A Ullrich, P Tsikouras, W Rath, G-F von Tempelhoff
No abstract text is available yet for this article.
April 2014: Clinical and Applied Thrombosis/hemostasis
Nandini Chakrabarti, Chandan Chattopadhyay
No abstract text is available yet for this article.
January 2012: Indian Dermatology Online Journal
Mikhail A Iakhiaev, Alexei V Iakhiaev
Different proteins, even without sequence similarity, still can contain similar surface regions involved in protein-protein interactions with common target. These regions can serve as structural determinants of cross-reactivity and molecular mimicry. Molecular mimicry, defined as the process in which structural properties of one molecule are simulated by the dissimilar molecules, is implicated in several biologically important processes, including autoimmune and allergic reactions, binding of some ligands to common receptor, and interactions in cell signaling...
January 2010: Molecular Immunology
Carlos Borelli Zeller, Simone Appenzeller
Atherosclerosis is a chronic inflammatory disorder characterized by immune cell activation, inflammation driven plaque formation and subsequent destabilization. In other disorders of an inflammatory nature, the chronic inflammatory state per se has been linked to acceleration of the atherosclerotic process which is underlined by an increased incidence of cardiovascular disease (CVD) in disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and antiphopholipid (Hughes) syndrome (APS)...
May 2008: Current Cardiology Reviews
Hiromi Terashi, Shiori Hashimoto, Shinichiro Uchiyama
Antiphopholipid syndrome (APS) is a major cause of ischemic stroke in young adults. In our study, stroke patients with antiphospholipid antibodies (APL) were significantly younger and were more likely to be women than stroke patients without APL. Valvular heart disease, neurological complications, and hematological disorders were more frequent in the APL-positive group. The mean value of thrombin-antithrombin III complex was significantly lower in the APL-positive group. beta2-Glyoprotein I (beta2-GPI) is the antigen primarily responsible for APL...
November 2008: Brain and Nerve, Shinkei Kenkyū No Shinpo
Y-M Pers, M Puygrenier, F Borlot, B Simorre, I Barazer, E Oziol, J-L Reny
INTRODUCTION: Antiphospholipid antibodies (aPL) can be associated with numerous infectious and particularly Q fever. Data on the pathogenicity of aPL in the course of acute Q fever are scarce. CASE REPORT: We report the case an acute Coxiella burnetii infection associated with clinical and biological manifestations of the aPL syndrome, including a renal infarction. Along with antibiotic treatment, anticoagulation and intravenous immunoglobulins, the clinical outcome was favourable...
March 2009: La Revue de Médecine Interne
Alon Y Hershko, Yackov Berkun, Dror Mevorach, Alan Rubinow, Yaakov Naparstek
OBJECTIVE: To assess whether increased intracranial pressure (IIP) is associated or coincidental with systemic lupus erythematosus (SLE) and to characterize the patients with this condition, its commonly used treatment, and outcome. METHODS: A retrospective cohort study was conducted at the Hadassah Medical Center, Jerusalem, Israel. Files were retrieved from the hospital archives by screening records from 1980 to 2006 using the terms "SLE" and "pseudotumor cerebri" or "benign intracranial pressure...
October 2008: Seminars in Arthritis and Rheumatism
Y W Nyandaiti, A A Gadzama, D Bukbuk
BACKGROUND: Antiphospholipid antibodies have been associated with variety of conditions. There is no standard health associated reference values required for the interpretation of antiphospholipid antibodies result available among adults in North- eastern Nigeria and Nigeria in general. The aim of this study is to determine the normal serum level (cutoffpoint) in healthy adult Nigerians. The need or otherwise for stratification of the reference values by sex would also be determined. METHODS: Seventy-six healthy adults' medical students and health workers were enrolled in the study over the period of twelve consecutive months...
September 2007: Nigerian Journal of Clinical Practice
Dharambir K Sanghera, Susan Manzi, Ryan L Minster, Penny Shaw, Amy Kao, Franklin Bontempo, M Ilyas Kamboh
Low serum paraoxonase1 (PON1) activity determined by paraoxon substrate is associated with coronary heart disease (CHD), diabetes and systemic lupus erythematosus (SLE) risk. In this investigation, we have examined the role of genetic variation in the PON3 gene in relation to PON1 activity and SLE risk in a biracial sample comprising 377 SLE patients and 482 controls from US whites and blacks. We genotyped six PON3 tagging single nucleotide polymorphisms (tagSNPs) and examined their associations with PON1 activity, SLE risk, antiphopholipid autoantibodies (APA), lupus nephritis, carotid vascular disease, and inflammation...
January 2008: Annals of Human Genetics
S Branger, N Schleinitz, V Veit, C Martaresche, M Bourlière, X Roblin, S Garcia, M San Marco, L Camoin, J-M Durand, J-R Harlé
INTRODUCTION: Only few series have reported the association of autoimmune hepatitis with antiphospholipid antibodies. The aim of our study is to investigate the frequency of these antibodies in a series of autoimmune hepatitis and to search for a correlation with clinical, biological or histological characteristics. MATERIAL AND METHODS: Antiphospholipid were investigated in 24 patients with well defined autoimmune hepatitis. Characteristics were compared between antiphopholipids positive and negative patients...
April 2007: La Revue de Médecine Interne
S I van Leuven, J J P Kastelein, D P D'Cruz, G R Hughes, E S Stroes
Atherosclerosis is a chronic inflammatory disorder characterized by immune cell activation, inflammation driven plaque formation and subsequent destabilization. In other disorders of an inflammatory nature, the chronic inflammatory state per se has been linked to acceleration of the atherosclerotic process which is underlined by an increased incidence of cardiovascular disease (CVD) in disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and antiphopholipid (Hughes) syndrome (APS)...
2006: Lupus
Shinichiro Uchiyama
Current topics and new developments in risk factors for ischemic stroke were reviewed. Hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation, cigarrette smoking, and heavy alcohol drinking have been established as being common treatable risk factors for stroke. Recent studies have clarified that homocysteine, various cardiac sources of embolism such as patent foramen ovale, antiphopholipid antibodies, lipoprotein (Lp) abnormalities including Lp(a) and remnant-like particle, insulin resistance or hyperinsulinemia, infectious diseases such as Chlamydia Pneumoniae, and CRP are additional risk factors for stroke...
November 2002: Rinshō Shinkeigaku, Clinical Neurology
Hyun-Sook Chi
Antiphospholipid antibodies are autoantibodies directed against anionic phospholipids or protein-phospholipid complexes measured in solid-phase immunoassays such as anticardiolipin (aCL) antibody or detected in phospholipid-dependent clotting tests as lupus anticoagulant (LA). The term "antiphospholipid syndrome (APS)" was first coined to denote the clinical association between antiphospholipid antibodies and a syndrome of episodes of thrombosis in arteries and/or veins, pregnancy loss, and thrombocytopenia...
August 2002: International Journal of Hematology
B Wechsler, D Lê Thi Huong, J C Piette
Acute disseminated lupus erythematosus primarily affects young women. The highly unfavorable influence of sex hormones is well known and women are advised against pregnancy. Therapeutic termination of pregnancy has been considered necessary. Regular progress in patient management has however completely changed the short, mid and long-term prognosis, although severe forms still resist treatment. As life expectancy improves, better disease control would allow revisiting the possibility of pregnancy. The spontaneous risk of an acute flare-up during pregnancy is debated but estimated in the 60% range...
September 1999: Annales de Médecine Interne
J C Gris, S Ripart-Neveu, C Maugard, M L Tailland, S Brun, C Courtieu, C Biron, M Hoffet, B Hédon, P Marès
The prevalence of haemostasis abnormalities was evaluated in 500 consecutive women with unexplained primary recurrent miscarriages. Two matched reference groups with no antecedent of miscarriage were studied: 100 healthy mothers and 50 childless women. In the prospective part of the study, we found 9.4% of the patients (95% C.I.: 6.8-12%) with an isolated factor XII deficiency, 7.4% of the patients (5.0-9.8%) with primary antiphopholipid antibodies, 47% of the patients (42.6-51.4%) with an insufficient response to the venous occlusion test and an isolated hypofibrinolysis was found in 42...
June 1997: Thrombosis and Haemostasis
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