Félix Sánchez-Valverde, Eva Martínez-Ojinaga, Ester Donat, Andrés Bodas, Eva Bandrés, Ricardo Torres, Berta Ibáñez, Mª Luz Cilleruelo, Gemma Castillejo, David Pérez-Solis, Carlos Ochoa, Francisco Javier Eizaguirre, Salvador García, Jose Ignacio García, Josefa Barrio, Raquel Vecino, María Del Carmen Miranda, Mercedes Juste, Jose Carlos Salazar, Honorio Armas, Luis Ortigosa, Pedro Urruzuno, Zuriñe García, Elena Balmaseda, Cecila Martínez, Enrique La Orden, Pilar Codoñer, Amadeu Roca, Carlos Trillo, Mercedes Sebastian, Ruth García, Luis Peña-Quintana, Patricia Barros, Marta Soria, Roger García, Begoña Pérez-Moneo, Isabel Polanco, Carmen Ribes, Enriqueta Román
Celiac disease is strongly associated with HLA DQ, specifically with haplotypes. DRB1*03-DQA1*05:01/DQB1*02:01 (DQ2.5),DRB1*07-DQA1*02:01/DQB1*02:02 (DQ2.2), DRB1*11-DQA1*05:05/DQB1*03:01 (DQ7.5), and DRB1*04-DQA1*03:01/DQB1*03:02 (DQ8). The distribution of these risk haplotypes in patients with celiac disease is different in the geographical areas investigated. A high frequency of DRB1*07- DQA1*02:01/DQB1*02:02 (DQ2.2) and DRB1*11-DQA1*05:05/DQB1*03:01 (DQ7.5), has been described in Southern Europe. We analyzed 2102 confirmed CD cases with information on both DQB1* alelles and their distribution by geographical area in Spain...
February 27, 2023: Human Immunology