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https://www.readbyqxmd.com/read/27920678/diffuse-bullous-eruptions-in-an-elderly-woman-late-onset-bullous-systemic-lupus-erythematosus
#1
Prajwal Boddu, Mojtaba Nadiri, Owais Malik
Vesiculobullous eruptions in the elderly represent a diverse range of varying pathophysiologies and can present a significant clinical dilemma to the diagnostician. Diagnosis requires a careful review of clinical history, attention to detail on physical and histomorphological examination, and appropriate immunofluorescence testing. We describe the case of a 73-year-old female who presented to our hospital with a painful blistering skin rash developed over 2 days. Examination of the skin was remarkable for numerous flaccid hemorrhagic bullae on a normal-appearing nonerythematous skin involving both the upper and lower extremities...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/27909085/a-negative-antinuclear-antibody-does-not-indicate-autoantibody-negativity-in-myositis-role-of-anticytoplasmic-antibody-as-a-screening-test-for-antisynthetase-syndrome
#2
Rohit Aggarwal, Namrata Dhillon, Noreen Fertig, Diane Koontz, Zengbiao Qi, Chester V Oddis
OBJECTIVE: To evaluate the utility of anticytoplasmic autoantibody (anti-CytAb) in antisynthetase antibody-positive (anti-SynAb+) patients. METHODS: Anti-SynAb+ patients were evaluated for antinuclear antibody (ANA) and anti-CytAb [cytoplasmic staining on indirect immunofluorescence (IIF)] positivity. Anti-SynAb+ patients included those possessing anti-Jo1 and other antisynthetase autoantibodies. Control groups included scleroderma, systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis, and healthy subjects...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27904866/sj%C3%A3-gren-syndrome-related-membranous-glomerulonephritis-progressing-to-membranoproliferative-glomerulonephritis
#3
Junko Yabuuchi, Tatsuya Suwabe, Toshiharu Ueno, Junichi Hoshino, Akinari Sekine, Noriko Hayami, Masahiko Oguro, Kyohei Kunisawa, Masahiro Kawada, Masayuki Yamanouchi, Keiichi Sumida, Hiroki Mizuno, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara
We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluorescent studies showed predominant deposition of IgG2 and IgG4. This patient was positive for antinuclear antibody and anti-SS-A antibody...
September 2016: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/27904495/higher-frequency-of-brain-abnormalities-in-neuromyelitis-optica-spectrum-disorder-patients-without-primary-sj%C3%A3-gren-s-syndrome
#4
Li-Na Gu, Min Zhang, Hui Zhu, Jing-Yao Liu
Neuromyelitis optica spectrum disorder often co-exists with primary Sjögren's syndrome. We compared the clinical features of 16 neuromyelitis optica spectrum disorder patients with (n = 6) or without primary Sjögren's syndrome (n = 10). All patients underwent extensive clinical, laboratory, and MRI evaluations. There were no statistical differences in demographics or first neurological involvement at onset between neuromyelitis optica spectrum disorder patients with and without primary Sjögren's syndrome...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27901249/depression-sexuality-and-fibromyalgia-syndrome-clinical-findings-and-correlation-to-hematological-parameters
#5
Bruna Alves, Telma M Zakka, Manoel J Teixeira, Helena H Kaziyama, Jose T T Siqueira, Silvia R D T Siqueira
Objective: To investigate sexuality and depression in women with FM compared with controls and to correlate the findings with hematological parameters. Methods: 33 women with FM and 19 healthy women were included and evaluated with the following instruments: Female Sexual Function Index, Beck Inventory, Visual Analogue Scale, medical history and laboratory exams. Results: The prevalence of sexual dysfunction (P = 0.007) and depression (P < 0...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27900970/clinical-features-and-histological-patterns-of-lupus-nephritis-in-a-single-center-of-south-india
#6
Clement Wilfred Devadass, Vijaya Viswanath Mysorekar, Mahesh Eshwarappa, Lakshminarayanan Mekala, M Gireesh Siddaiah, K Gurudev Channabasappa
Renal involvement occurs in up to 60% of patients with systemic lupus erythematosus (SLE) and signifies a poor prognosis. The class of lupus nephritis (LN), determined on renal biopsy evaluation, guides the therapeutic management and has prognostic connotations. Our aim is to determine the clinicolaboratory features and histopathological patterns of LN at presentation in our local (South Indian) population. The study was conducted in a tertiary care hospital in South India between 2009 and 2014 on SLE patients with clinical evidence of LN...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27899373/influence-of-geolocation-and-ethnicity-on-the-phenotypic-expression-of-primary-sj%C3%A3-gren-s-syndrome-at-diagnosis-in-8310-patients-a-cross-sectional-study-from-the-big-data-sj%C3%A3-gren-project-consortium
#7
Pilar Brito-Zerón, Nihan Acar-Denizli, Margit Zeher, Astrid Rasmussen, Raphaele Seror, Elke Theander, Xiaomei Li, Chiara Baldini, Jacques-Eric Gottenberg, Debashish Danda, Luca Quartuccio, Roberta Priori, Gabriela Hernandez-Molina, Aike A Kruize, Valeria Valim, Marika Kvarnstrom, Damien Sene, Roberto Gerli, Sonja Praprotnik, David Isenberg, Roser Solans, Maureen Rischmueller, Seung-Ki Kwok, Gunnel Nordmark, Yasunori Suzuki, Roberto Giacomelli, Valerie Devauchelle-Pensec, Michele Bombardieri, Benedikt Hofauer, Hendrika Bootsma, Johan G Brun, Guadalupe Fraile, Steven E Carsons, Tamer A Gheita, Jacques Morel, Cristina Vollenveider, Fabiola Atzeni, Soledad Retamozo, Ildiko Fanny Horvath, Kathy Sivils, Thomas Mandl, Pulukool Sandhya, Salvatore De Vita, Jorge Sanchez-Guerrero, Eefje van der Heijden, Virginia Fernandes Moça Trevisani, Marie Wahren-Herlenius, Xavier Mariette, Manuel Ramos-Casals
OBJECTIVES: To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. RESULTS: We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years...
November 29, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27896669/detection-of-autoantibodies-to-dsf70-ledgfp75-in-mexican-hispanics-using-multiple-complementary-assay-platforms
#8
Mónica Vázquez-Del Mercado, Eduardo Gómez-Bañuelos, Rosa Elena Navarro-Hernández, Oscar Pizano-Martinez, Adan Saldaña-Millán, Efrain Chavarria-Avila, Lorena Gonzalez-Rosas, Lilia Andrade-Ortega, Miguel Angel Saavedra, Olga Lidia Vera-Lastra, Luis Javier Jara, Gabriel Medrano-Ramírez, Claudia Cruz-Reyes, Ignacio García-De la Torre, Marta Escarra-Senmarti, Lisiane Maria Enriconi-Dos Anjos, Anamika Basu, Roger Albesa, Michael Mahler, Carlos A Casiano
PURPOSE: Antinuclear autoantibodies (ANA) targeting the dense fine speckled antigen DFS70, also known as lens epithelium-derived growth factor p75 (LEDGF/p75), are attracting attention due to their low frequency in systemic rheumatic diseases but increased frequency in clinical laboratory referrals and healthy individuals (HI). These ANA specifically recognize the stress protein DFS70/LEDGFp75, implicated in cancer, HIV-AIDS, and inflammation. While their frequency has been investigated in various ethnic populations, there is little information on their frequency among Hispanics/Latinos...
December 2017: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/27893665/is-it-relevant-to-screen-young-women-hospitalized-in-psychiatric-department-for-neuropsychiatric-systemic-lupus-erythematosus-npsle-a-prospective-study-of-100-psychiatric-inpatients
#9
Alexandra Audemard-Verger, Elizabeth Comby, Clément Nathou, Audrey Sultan, Mathieu Frémont, Aurélie Baldolli, Louis Simon Trumier, Vincent Marzloff, Brigitte Le Mauff, Jennifer Manuzak, Sonia Dollfus, Boris Bienvenu
On the basis that diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is sometimes difficult and systemic lupus erythematosus (SLE) can present with isolated psychiatric symptoms, we initiated a survey in a psychiatric department to screen for NPSLE in young female inpatients.We prospectively studied consecutive young female patients referred to the department of psychiatry. Antinuclear antibodies (ANA), anti-deoxyribonucleic acid (DNA), and antiextractable soluble nuclear antigens (ENA) in the serum of patients were screened...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27893578/propylthiouracil-associated-leukocytoclastic-necrotizing-cutaneous-vasculitis-a-case-report-and-review-of-the-literature
#10
Anji E Wall, Sheena M Weaver, Jeffrey S Litt, Lisa Rae
The purpose of this case report and review of the literature is to provide an exploration of the clinical symptoms, diagnosis, prevention, and management of propylthiouracil (PTU)-associated vasculitis in the intensive care setting. A PubMed search of the available literature was conducted using the MeSH search terms "propylthiouracil" and "vasculitis." The literature search returned 121 articles. Twenty-five were excluded because they were not in English. Fifty-nine case reports or case studies describing PTU-associated vasculitis were included...
November 11, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27884272/50-years-ago-in-thejournal-ofpediatrics-antinuclear-factors-in-childhood-rheumatic-diseases
#11
Philip J Hashkes
No abstract text is available yet for this article.
December 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27872779/ultra-wide-field-fluorescein-angiography-in-microscopic-polyangiitis
#12
Philip P Storey, Shannon A Philander, Anna Ter-Zakarian, Narsing A Rao, Damien C Rodger
A 25-year-old Hispanic female presented with 5 months of dry eyes and 2 months of bilateral photophobia and decreased vision. On examination, she had bilateral anterior uveitis and mild disc edema of the left eye. A complete infectious and inflammatory work-up was positive for elevated antinuclear antibodies and p-ANCA, leading to a diagnosis of microscopic polyangiitis. One year after initial treatment and steroid taper, an ultra-wide-field fluorescein angiography revealed peripheral vasculitis, outside of the standard traditional field of view, leading to an increase in immunomodulatory therapy and illustrating the utility of wide-field angiography for managing patients with uveitis...
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27872767/diffuse-alveolar-hemorrhage-associated-with-edoxaban-therapy
#13
Kenichi Nitta, Hiroshi Imamura, Akihiro Yashio, Satoko Kashima, Katsunori Mochizuki
Introduction. The main adverse effect of anticoagulant therapy is bleeding, and major bleeding, including intracranial, gastrointestinal, and retroperitoneal bleeding, has been reported as an adverse effect of edoxaban, a direct oral anticoagulant (DOAC). Bleeding during systemic anticoagulation with edoxaban presents a therapeutic conundrum, because there is currently no safe or efficacious reversal agent to stop major bleeding. Case Report. A 51-year-old woman had multiple traumatic injuries, including lower limb fractures...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27864990/the-clinical-relevance-of-anti-fibrillarin-anti-u3-rnp-autoantibodies-in-systemic-sclerosis
#14
F Tall, M Dechomet, S Riviere, V Cottin, E Ballot, K P Tiev, R Montin, C Morin, Y Chantran, C Grange, D Jullien, J Ninet, P Chretien, J Cabane, N Fabien, C Johanet
OBJECTIVES: Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of anti-fibrillarin autoantibodies (AFA) in patients with SSc. METHODS: The clinical features of 37 SSc patients positive for AFA (AFA+) and 139 SSc patients without AFA (AFA-) were collected retrospectively from medical records to enable a comparison between AFA- and AFA+ patients...
November 16, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27864697/characteristics-of-primary-sj%C3%A3-gren-s-syndrome-patients-with-igg4-positive-plasma-cells-infiltration-in-the-labial-salivary-glands
#15
Chang Liu, Huayong Zhang, Genhong Yao, Yunxia Hu, Jingjing Qi, Yan Wang, Weiwei Chen, Xiaojun Tang, Wenchao Li, Liwei Lu, Luo Gu, Lingyun Sun
The purpose of this study was to investigate the characteristics of primary Sjögren's syndrome (pSS) patients with IgG4 positive (IgG4(+)) plasma cell infiltration in labial salivary glands (LSGs). Paraffin sections of LSGs from 336 pSS patients were stained with IgG4 and IgG monoclonal antibodies. According to the infiltration of IgG4(+) plasma cells, patients were divided and clinical and serological characteristics were analyzed and compared. Based on the infiltration of IgG4(+) plasma cells in the LSGs, patients were divided into three subgroups, low IgG4, moderate IgG4, and high IgG4 groups...
November 18, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27862036/association-of%C3%AE-1-adrenergic%C3%A3-m2-muscarinic-receptor-autoantibody-with-occurrence-and-development-of-nonvalvular-atrial-fibrillation
#16
Bing Hu, Yanxiang Sun, Sha Li, Jie Sun, Tong Liu, Zidi Wu, L I Feng
BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia and an independent increased risk of stroke and death. Although the exact mechanisms of AF are not completely elucidated, a large number of evidences demonstrate that autoimmunity may play an important role in the initiation, the progression and the maintenance of AF. In this study, we aimed to compare Anti-β1-Adrenergic Receptor Autoantibody (anti-β1 -R) and Anti- M2-Muscarinic Receptor Autoantibody(anti-M2 -R) levels between non-valvular AF patients and healthy control subjects...
November 10, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27861944/chronic-parotitis-with-multiple-calcifications-clinical-and-sialendoscopic-findings
#17
Emmanuel Jáuregui, Ruwan Kiringoda, William R Ryan, David W Eisele, Jolie L Chang
OBJECTIVES/HYPOTHESIS: To characterize clinical, imaging, and sialendoscopy findings in patients with chronic parotitis and multiple parotid calcifications. STUDY DESIGN: Retrospective review. METHODS: Clinical history, radiographic images and reports, lab tests, and operative reports were reviewed for adult patients with chronic parotitis and multiple parotid calcifications who underwent parotid sialendoscopy. RESULTS: Thirteen of 133 (10%) patients undergoing parotid sialendoscopy for chronic sialadenitis had more than one calcification in the region of the parotid gland...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27843539/regulatory-and-activated-effector-t-cells-in-chronic-hepatitis-c-virus-relation-to-autoimmunity
#18
Hanan Fouad, Maissa El Raziky, Eman Medhat Hassan, Ghada Mahmoud Abdel Aziz, Samar K Darweesh, Ahmed Reda Sayed
AIM: To investigate how Tregs are regulated in chronic hepatitis C virus (HCV) patients via assessment of Tregs markers (granzyme 2, CD69 and FoxP3), Teffs markers [TNFRSF4 (OX40), INFG] and CD4, CD25 genes. METHODS: A prospective study was conducted on 120 subjects divided into 4 groups: Group I (n = 30) treatment naïve chronic HCV patients; Group II (n = 30) chronic HCV treated with Peg/Riba; Group III (n = 30) chronic HCV associated with non-organ specific autoantibody and Group IV (n = 30) healthy persons as a control group...
October 28, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27843373/the-onset-of-rheumatoid-arthritis-following-trauma
#19
Arthur E Brawer, Noopur Goel
BACKGROUND: Rheumatoid arthritis (RA) is known to have many predisposing factors. OBJECTIVE: We studied individuals whose RA was initiated by physical injuries. PATIENTS AND METHODS: Sixty patients (43 females), previously well, developed RA following trauma. No other known environmental or familial influences were present. Fourteen sustained a fracture; of the 46 who did not, 36 sustained multiple injuries that in part involved the axial skeleton...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27835759/zika-virus-epidemic-in-brazil-i-fatal-disease-in-adults-clinical-and-laboratorial-aspects
#20
Raimunda S S Azevedo, Marialva T Araujo, Arnaldo J Martins Filho, Consuelo S Oliveira, Bruno T D Nunes, Ana C R Cruz, Ana G P A C Nascimento, Rita C Medeiros, Cezar A M Caldas, Fernando C Araujo, Juarez A S Quaresma, Barbara C B Vasconcelos, Maria G L Queiroz, Elizabeth S Travassos da Rosa, Daniele F Henriques, Eliana V P Silva, Jannifer O Chiang, Lívia C Martins, Daniele B A Medeiros, Juliana A Lima, Márcio R T Nunes, Jedson F Cardoso, Sandro P Silva, Pei-Yong Shi, Robert B Tesh, Sueli G Rodrigues, Pedro F C Vasconcelos
BACKGROUND: Zika virus (ZIKV) was first detected in Brazil in May 2015 and the country experienced an explosive epidemic. However, recent studies indicate that the introduction of ZIKV occurred in late 2013. Cases of microcephaly and deaths associated with ZIKV infection were identified in Brazil in November, 2015. OBJECTIVES: To determine the etiology of three fatal adult cases. STUDY DESIGN: Here we report three fatal adult cases of ZIKV disease...
December 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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