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https://www.readbyqxmd.com/read/27933585/effect-of-rheology-and-poloxamers-properties-on-release-of-drugs-from-silicon-dioxide-gel-filled-hard-gelatin-capsules-a-further-enhancement-of-viability-of-liquid-semisolid-matrix-technology
#1
Misbah Sultana, Mobashar Ahmad Butt, Tariq Saeed, Rizwan Mahmood, Saeed Ul Hassan, Khalid Hussain, Syed Atif Raza, Muhammad Ahsan, Nadeem Irfan Bukhari
The liquid and semisolid matrix technology, filling liquids, semi-solids and gels in hard gelatin capsule are promising, thus, there is a need of enhanced research interest in the technology. Therefore, the present study was aimed to investigate isoniazid (freely soluble) and metronidazole (slightly soluble) gels filled in hard gelatin capsules for the effect of poloxamers of different viscosities on release of the drugs. Gel of each drug (10% w/w, particle size 180-250 μm), prepared by mixing poloxamer and 8% w/w hydrophilic silicon dioxide (Aerosil® A200), was assessed for rheology, dispersion stability and release profile...
December 8, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27933105/prevalence-of-atrial-fibrillation-in-the-malaysian-communities
#2
Chiao Wen Lim, Sazzli Kasim, Johan Rizwal Ismail, Nicholas Yul Chye Chua, Rizmy Najme Khir, Hafisyatul Aiza Zainal Abidin, Effarezan Abdul Rahman, Mohd Kamal Mohd Arshad, Zubin Ibrahim Othman, Khalid Yusoff
BACKGROUND AND AIM: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice. The REDISCOVER (Responding to Increasing Cardiovascular disease prevalence) study is an observational longitudinal community-based study that tracks changing lifestyles, risk factors and chronic disease in urban and rural areas of Malaysia. In this study, we aim to study the prevalence of AF and its associated risk factors. METHODS: The study was conducted between 2007 and 2014...
2016: Heart Asia
https://www.readbyqxmd.com/read/27932512/atf6-decreases-myocardial-ischemia-reperfusion-damage-and-links-er-stress-and-oxidative-stress-signaling-pathways-in-the-heart
#3
Jung-Kang Jin, Erik A Blackwood, Khalid M Azizi, Donna J Thuerauf, Asal G Fahem, Christoph Hofmann, Randal J Kaufman, Shirin Doroudgar, Christopher C Glembotski
RATIONALE: ER stress causes accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6, which induces ER stress response genes. Myocardial ischemia induces the ER stress response; however, neither the function of this response nor whether it is mediated by ATF6 is known. OBJECTIVE: Here, we examined the effects of blocking the ATF6-mediated ER stress response on ischemia/reperfusion (I/R) in cardiac myocytes and mouse hearts. METHODS AND RESULTS: Knockdown of ATF6 in cardiac myocytes subjected to I/R increased ROS and necrotic cell death, which were mitigated by ATF6 overexpression...
December 8, 2016: Circulation Research
https://www.readbyqxmd.com/read/27931681/mycobacterial-contamination-of-bronchoscopes-challenges-and-possible-solutions-in-low-resource-settings
#4
Dania Khalid Saeed, Sadia Shakoor, Seema Irfan, Rumina Hasan
The use of bronchoscopes has increased in tuberculosis (TB) diagnostics to circumvent the diagnostic challenges that are associated with low sputum volume and smear-negative TB. In healthcare facilities situated in low income countries that have a high burden of TB, adequate decontamination of bronchoscopes is a challenge and often overlooked to save on time and costs. This amplifies the risk of outbreaks and pseudo-outbreaks due to Mycobacterium tuberculosis and nontuberculosis mycobacteria. In this minireview, we review published literature of contaminated bronchoscopes causing pseudo-outbreaks of M...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27931679/extrapulmonary-tuberculosis-among-females-in-south-asia-gap-analysis
#5
Jaishri Mehraj, Zain Yar Khan, Dania Khalid Saeed, Sadia Shakoor, Rumina Hasan
The percentage of extrapulmonary tuberculosis (EPTB) among new and relapse tuberculosis cases in South Asia (Afghanistan, Pakistan, India, and Bangladesh) ranged from 19% to 23% in 2014. While tuberculosis was reportedly more prevalent in males, a higher preponderance of EPTB was observed in females. National tuberculosis control programs are highly focused on pulmonary tuberculosis. This creates gaps in the surveillance, diagnosis, and study of EPTB among females, which is especially pronounced in the South Asian setting...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27931350/in-reply-1
#6
Lorena Mota, Khalid Al-Efraij, Jonathon Campbell, Victoria Cook, Fawziah Marra Lalji, James Johnston
No abstract text is available yet for this article.
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931255/wealth-and-cardiovascular-health-a-cross-sectional-study-of-wealth-related-inequalities-in-the-awareness-treatment-and-control-of-hypertension-in-high-middle-and-low-income-countries
#7
Benjamin Palafox, Martin McKee, Dina Balabanova, Khalid F AlHabib, Alvaro Jr Avezum, Ahmad Bahonar, Noorhassim Ismail, Jephat Chifamba, Clara K Chow, Daniel J Corsi, Gilles R Dagenais, Rafael Diaz, Rajeev Gupta, Romaina Iqbal, Manmeet Kaur, Rasha Khatib, Annamarie Kruger, Iolanthe Marike Kruger, Fernando Lanas, Patricio Lopez-Jaramillo, Fu Minfan, Viswanathan Mohan, Prem K Mony, Aytekin Oguz, Lia M Palileo-Villanueva, Pablo Perel, Paul Poirier, Sumathy Rangarajan, Lei Rensheng, Annika Rosengren, Biju Soman, David Stuckler, S V Subramanian, Koon Teo, Lungiswa P Tsolekile, Andreas Wielgosz, Peng Yaguang, Karen Yeates, Mo Yongzhen, Khalid Yusoff, Rita Yusuf, Afzalhussein Yusufali, Katarzyna Zatońska, Salim Yusuf
BACKGROUND: Effective policies to control hypertension require an understanding of its distribution in the population and the barriers people face along the pathway from detection through to treatment and control. One key factor is household wealth, which may enable or limit a household's ability to access health care services and adequately control such a chronic condition. This study aims to describe the scale and patterns of wealth-related inequalities in the awareness, treatment and control of hypertension in 21 countries using baseline data from the Prospective Urban and Rural Epidemiology study...
December 8, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27928080/burden-of-diarrhea-in-the-eastern-mediterranean-region-1990-2013-findings-from-the-global-burden-of-disease-study-2013
#8
Ibrahim Khalil, Danny V Colombara, Mohammad Hossein Forouzanfar, Christopher Troeger, Farah Daoud, Maziar Moradi-Lakeh, Charbel El Bcheraoui, Puja C Rao, Ashkan Afshin, Raghid Charara, Kalkidan Hassen Abate, Mohammed Magdy Abd El Razek, Foad Abd-Allah, Remon Abu-Elyazeed, Aliasghar Ahmad Kiadaliri, Ali Shafqat Akanda, Nadia Akseer, Khurshid Alam, Deena Alasfoor, Raghib Ali, Mohammad A AlMazroa, Mahmoud A Alomari, Rajaa Mohammad Salem Al-Raddadi, Ubai Alsharif, Shirina Alsowaidi, Khalid A Altirkawi, Nelson Alvis-Guzman, Walid Ammar, Carl Abelardo T Antonio, Hamid Asayesh, Rana Jawad Asghar, Suleman Atique, Ashish Awasthi, Umar Bacha, Alaa Badawi, Aleksandra Barac, Neeraj Bedi, Tolesa Bekele, Isabela M Bensenor, Balem Demtsu Betsu, Zulfiqar Bhutta, Aref A Bin Abdulhak, Zahid A Butt, Hadi Danawi, Manisha Dubey, Aman Yesuf Endries, Imad D A Faghmous, Talha Farid, Maryam S Farvid, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Florian Fischer, Joseph Robert Anderson Fitchett, Katherine B Gibney, Ibrahim Abdelmageem Mohamed Ginawi, Melkamu Dedefo Gishu, Harish Chander Gugnani, Rahul Gupta, Gessessew Bugssa Hailu, Randah Ribhi Hamadeh, Samer Hamidi, Hilda L Harb, Mohammad T Hedayati, Mohamed Hsairi, Abdullatif Husseini, Nader Jahanmehr, Mehdi Javanbakht, Tariku Jibat, Jost B Jonas, Amir Kasaeian, Yousef Saleh Khader, Abdur Rahman Khan, Ejaz Ahmad Khan, Gulfaraz Khan, Tawfik Ahmed Muthafer Khoja, Yohannes Kinfu, Niranjan Kissoon, Ai Koyanagi, Aparna Lal, Asma Abdul Abdul Latif, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Azeem Majeed, Reza Malekzadeh, Alem Mehari, Alemayehu B Mekonnen, Yohannes Adama Melaku, Ziad A Memish, Walter Mendoza, Awoke Misganaw, Layla Abdalla Ibrahim Mohamed, Jean B Nachega, Quyen Le Nguyen, Muhammad Imran Nisar, Emmanuel Kwame Peprah, James A Platts-Mills, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Rajesh Kumar Rai, Saleem M Rana, Chhabi L Ranabhat, Sowmya R Rao, Amany H Refaat, Mark Riddle, Gholamreza Roshandel, George Mugambage Ruhago, Muhammad Muhammad Saleh, Juan R Sanabria, Monika Sawhney, Sadaf G Sepanlou, Tesfaye Setegn, Karen Sliwa, Chandrashekhar T Sreeramareddy, Bryan L Sykes, Mohammad Tavakkoli, Bemnet Amare Tedla, Abdullah S Terkawi, Kingsley Ukwaja, Olalekan A Uthman, Ronny Westerman, Mamo Wubshet, Muluken A Yenesew, Naohiro Yonemoto, Mustafa Z Younis, Zoubida Zaidi, Maysaa El Sayed Zaki, Abdullah A Al Rabeeah, Haidong Wang, Mohsen Naghavi, Theo Vos, Alan D Lopez, Christopher J L Murray, Ali H Mokdad
Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years (DALYs), which are the sum of years of life lost and years lived with disability...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27928011/high-prevalence-of-infectious-adeno-associated-virus-aav-in-human-peripheral-blood-mononuclear-cells-indicative-of-t-lymphocytes-as-sites-of-aav-persistence
#9
Daniela Hüser, Dina Khalid, Timo Lutter, Eva-Maria Hammer, Stefan Weger, Melanie Heßler, Ulrich Kalus, Yvonne Tauchmann, Karin Hensel-Wiegel, Dirk Lassner, Regine Heilbronn
: Seroepidemiology shows that infections with adeno-associated virus (AAV) are widespread, but diverse AAV serotypes isolated from man or non-human primates have so far not been proven as causes of human disease. In view of the increasing success of AAV-derived vectors in human gene therapy, the definition of the in vivo sites of wild-type AAV persistence and clinical consequences of its reactivation are becoming increasingly urgent.Here, we identified the presumed cell-type for AAV persistence in the human host, by highly sensitive AAV PCRs developed for the full spectrum of human AAV serotypes...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27926912/cranioplasty-after-craniectomy-in-a-pediatric-population-single-center-experience-from-a-developing-country
#10
Muhammad Waqas, Badar Ujjan, Yousaf Bashir Hadi, Faizuddin Najmuddin, Altaf Ali Laghari, Swaleha Khalid, Muhammad Ehsan Bari, Umar Farooq Bhatti
Cranioplasty is a frequently performed procedure in neurosurgery. The pediatric population for this procedure is distinct from the adult one because of the growing skulls and thinner bones of the calvarium. A paucity of data on the outcomes of this procedure in the pediatric population has been identified repeatedly. We conducted a retrospective cohort study to investigate the outcomes in a pediatric population that underwent cranioplasty after craniectomy at our institute in a developing-world country. Our cohort showed no association of complication rate or cosmetic outcomes with the timing of cranioplasty, area of skull defect, type of implant used, or method of storage...
December 8, 2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27921062/long-qt-syndrome-and-duodenal-ampullary-adenoma-a-new-association
#11
F N U Asad-Ur-Rahman, Laura Hughes, Muhammad Talha Khan, Muhammad Khalid Hasan, Irteza Inayat
KCNQ1 gene mutation has a well-known association with long QT syndrome (LQTS). However, recent studies suggest that it may be implicated in intestinal neoplasia. We present a 27-year-old Hispanic man with a known history of LQTS secondary to KCNQ1 mutation, who presented with painless jaundice. Endoscopic retrograde pancreatic cholangiography revealed a prominent ampulla, with histology consistent with ampullary adenoma with high-grade dysplasia. Further endoscopic studies did not suggest familial adenomatous polyposis...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27920858/beware-of-positive-pressure-coronary-artery-air-embolism-following-percutaneous-lung-biopsy
#12
Dmitriy N Kazimirko, William B Beam, Khalid Saleh, Akash M Patel
Patients undergoing percutaneous lung biopsy are at risk of developing a systemic air embolism. Air embolism may manifest as a catastrophic iatrogenic event with ischemic insult to the end organs, with sites of least resistance such as coronary and cerebral circulation the most susceptible. We review the available literature and present a case of iatrogenic air embolism during computed tomography guided percutaenous lung biopsy under general anesthesia. Management, outcome, and periprocedural factors that may have contributed to the complication are discussed...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920760/prevalence-of-the-antibiotic-resistance-genes-in-coagulase-positive-and-negative-staphylococcus-in-chicken-meat-retailed-to-consumers
#13
Kamelia Osman, Jihan Badr, Khalid S Al-Maary, Ihab M I Moussa, Ashgan M Hessain, Zeinab M S Amin Girah, Usama H Abo-Shama, Ahmed Orabi, Aalaa Saad
The use of antibiotics in farm management (growing crops and raising animals) has become a major area of concern. Its implications is the consequent emergence of antibiotic resistant bacteria (ARB) and accordingly their access into the human food chain with passage of antibiotic resistance genes (ARG) to the normal human intestinal microbiota and hence to other pathogenic bacteria causative human disease. Therefore, we pursued in this study to unravel the frequency and the quinolone resistance determining region, mecA and cfr genes of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27920410/a-novel-splice-site-mutation-in-the-aspm-gene-underlies-autosomal-recessive-primary-microcephaly
#14
Jamil A Hashmi, Khalid M Al-Harbi, Khushnooda Ramzan, Alia M Albalawi, Amir Mehmood, Mohammed I Samman, Sulman Basit
BACKGROUND: Autosomal recessive primary microcephaly (MCPH) is a clinically and genetically heterogeneous disorder. Patients with MCPH exhibit reduced occipito-frontal head circumference and non-progressive intellectual disability. To date, 17 genes have been known as an underlying cause of MCPH in humans. ASPM (abnormal spindle-like, microcephaly associated) is the most commonly mutated MCPH gene. OBJECTIVE: Identify the genetic defect underlying MCPH in a Saudi family...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27920409/prevalence-of-igg-mediated-food-intolerance-among-patients-with-allergic-symptoms
#15
Zahid Shakoor, Abrar AlFaifi, Bayan AlAmro, Lama Nabil AlTawil, Rana Yazid AlOhaly
BACKGROUND: Food intolerance mediated by food specific IgG antibodies has been implicated in a variety of disorders. OBJECTIVES: To assess the prevalence of food specific IgG antibodies among patients clinically presenting with allergic symptoms lacking laboratory evidence of allergy. DESIGN: Descriptive retrospective cross-sectional study. SETTING: King Khalid University Hospital, Riyadh between 2010-2015. PATIENTS AND METHODS: Patients were screened for food specific IgG antibodies...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27918584/the-ace-1-locus-is-amplified-in-all-resistant-anopheles-gambiae-mosquitoes-fitness-consequences-of-homogeneous-and-heterogeneous-duplications
#16
Benoît S Assogba, Pascal Milesi, Luc S Djogbénou, Arnaud Berthomieu, Patrick Makoundou, Lamine S Baba-Moussa, Anna-Sophie Fiston-Lavier, Khalid Belkhir, Pierrick Labbé, Mylène Weill
Gene copy-number variations are widespread in natural populations, but investigating their phenotypic consequences requires contemporary duplications under selection. Such duplications have been found at the ace-1 locus (encoding the organophosphate and carbamate insecticides' target) in the mosquito Anopheles gambiae (the major malaria vector); recent studies have revealed their intriguing complexity, consistent with the involvement of various numbers and types (susceptible or resistant to insecticide) of copies...
December 2016: PLoS Biology
https://www.readbyqxmd.com/read/27918383/etiology-of-acute-otitis-media-in-children-less-than-5-years-of-age-a-pooled-analysis-of-10-similarly-designed-observational-studies
#17
Melissa K Van Dyke, Jean-Yves Pirçon, Robert Cohen, Shabir A Madhi, Andrés Rosenblüt, Mercedes Macias Parra, Khalid Al-Mazrou, Gerhard Grevers, Pio Lopez, Laura Naranjo, Felix Pumarola, Nuntigar Sonsuwan, William P Hausdorff
BACKGROUND: Acute otitis media (AOM) is an important cause of childhood morbidity and antibiotic prescriptions. However, the relative importance of the well-known otopathogens, Streptococcus pneumoniae (Spn) and Haemophilus influenzae (Hflu), remains unclear due to a limited number of tympanocentesis-based studies that vary significantly in populations sampled, case definitions, and heptavalent pneumococcal conjugate vaccine (PCV7-CRM) use. METHODS: We conducted a pooled analysis of results from ten AOM etiology studies of similar design the protocols of which were derived from a common protocol and conducted in children 3 months to 5 years of age in different countries...
November 30, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27917708/synthesis-spectroscopic-characterization-and-antimicrobial-activities-of-benzoxazolone-derivatives
#18
Nida Iqbal Siddiqui, Muhammad Ali Versiani, Khurshid Jawaid, Maryam Shafique, Abdul Hameed, Nida Ambreen, Aneela Karim, Khalid Mohammed Khan
: : Background: Pathogenic microbial diseases are now the key virulence in our daily life. Significant research has been carried out in order to trigger the bacterial infections. Amongst the organic molecules, oxazolone and derivatives were found to have excellent bioactivities including antimicrobial activities. METHODS: By keeping in mind the considerable antimicrobial activities of class benzoxazolones, a series of benzoxazolone derivatives 3-16 have been synthesized...
December 5, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27917540/interaction-of-procarbazine-with-calf-thymus-dna-a-biophysical-and-molecular-docking-study
#19
Razique Anwer, Nazia Ahmad, Khalid I Al Qumaizi, Osama A Al Khamees, Waleed Mohammed Al Shaqha, Tasneem Fatma
Interaction of procarbazine (PCZ) with calf thymus DNA was studied using biophysical and molecular docking studies. Procarbazine was to interact with DNA with a binding constant of 6.52 × 10(3)  M(-1) as calculated using ultraviolet-visible spectroscopy. To find out the binding mode, molecular docking was performed that predicted PCZ to interact with DNA through groove binding mode with binding affinity of -6.7 kcal/mole. To confirm the groove binding nature, different experiments were performed. Dye displacement assays confirmed the non-intercalative binding mode...
December 5, 2016: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/27916704/design-and-development-of-dry-powder-sulfobutylether-%C3%AE-cyclodextrin-complex-for-pulmonary-delivery-of-fisetin
#20
Noratiqah Mohtar, Kevin M G Taylor, Khalid Sheikh, Satyanarayana Somavarapu
This study has investigated complexation of fisetin, a natural flavonoid, with three types of cyclodextrins to improve its solubility. Sulfobutylether-β-cyclodextrin (SBE-β-CD) showed the highest complexation efficiency while maintaining the in vitro antioxidant activity of fisetin. Addition of 20%v/v ethanol in water improved the amount of solubilized fisetin in the complex 5.9-fold compared to the system containing water alone. Spray drying of fisetin-SBE-β-CD complex solution in the presence of ethanol produced a dry powder with improved aerosolization properties when delivered from a dry powder inhaler, indicated by a 2-fold increase in the fine particle fraction (FPF) compared to the powder produced from the complex solution containing water alone...
December 1, 2016: European Journal of Pharmaceutics and Biopharmaceutics
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