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https://www.readbyqxmd.com/read/28335200/structural-and-magnetic-response-in-bimetallic-core-shell-magnetic-nanoparticles
#1
Adeela Nairan, Usman Khan, Munawar Iqbal, Maaz Khan, Khalid Javed, Saira Riaz, Shahzad Naseem, Xiufeng Han
Bimagnetic monodisperse CoFe₂O₄/Fe₃O₄ core/shell nanoparticles have been prepared by solution evaporation route. To demonstrate preferential coating of iron oxide onto the surface of ferrite nanoparticles X-ray diffraction (XRD), High resolution transmission electron microscope (HR-TEM) and Raman spectroscopy have been performed. XRD analysis using Rietveld refinement technique confirms single phase nanoparticles with average seed size of about 18 nm and thickness of shell is 3 nm, which corroborates with transmission electron microscopy (TEM) analysis...
April 14, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335005/tdp-43-suppresses-tau-expression-via-promoting-its-mrna-instability
#2
Jianlan Gu, Feng Wu, Wen Xu, Jianhua Shi, Wen Hu, Nana Jin, Wei Qian, Xinglong Wang, Khalid Iqbal, Cheng-Xin Gong, Fei Liu
In the brains of individuals with Alzheimer's disease (AD) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response DNA-binding protein 43 (TDP-43). However, the role of TDP-43 in tau pathogenesis is not understood. Here, we investigated the role of TDP-43 in tau expression in vitro and in vivo. We found that TDP-43 suppressed tau expression by promoting its mRNA instability through the UG repeats of its 3΄-untranslated region (3΄-UTR)...
March 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334646/defluoridation-of-drinking-water-using-a-new-flow-column-electrocoagulation-reactor-fcer-experimental-statistical-and-economic-approach
#3
Khalid S Hashim, Andy Shaw, Rafid Al Khaddar, Montserrat Ortoneda Pedrola, David Phipps
A new batch, flow column electrocoagulation reactor (FCER) that utilises a perforated plate flow column as a mixer has been used to remove fluoride from drinking water. A comprehensive study has been carried out to assess its performance. The efficiency of fluoride removal (R%) as a function of key operational parameters such as initial pH, detention time (t), current density (CD), inter-electrode distance (ID) and initial concentration (C0) has been examined and an empirical model has been developed. A scanning electron microscopy (SEM) investigation of the influence of the EC process on morphology of the surface of the aluminium electrodes, showed the erosion caused by aluminium loss...
March 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28331912/effect-of-visible-range-electromagnetic-radiations-on-escherichia-coli
#4
Samina T Yousuf Azeemi, Saleem Farooq Shaukat, Khawaja Shamsuddin Azeemi, Idrees Khan, Khalid Mahmood, Farah Naz
BACKGROUND: Escherichia coli is the agent responsible for a range of clinical diseases. With emerging antimicrobial resistance, other treatment options including solar/photo-therapy are becoming increasingly common. Visible Range Radiation Therapy/Colour Therapy is an emerging technique in the field of energy/vibrational medicine that uses visible spectrum of Electromagnetic Radiations to cure different diseases. In this study, our goal was to understand the effect of Visible Range Electromagnetic Radiations on E...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28330141/evaluation-of-biochemical-markers-during-somatic-embryogenesis-in-silybum-marianum-l
#5
Bilal Haider Abbasi, Huma Ali, Buhara Yücesan, Sabahat Saeed, Khalid Rehman, Mubarak Ali Khan
In present report effects of explants type, basal media and plant growth regulators (PGRs) were tested for induction of indirect somatic embryogenesis in medicinally important plant Silybum marianum L. Leaf, petiole and root explants were exploited in vitro on B5 (Gamborg), SH (Schenk and Hildebrandt) and MS (Murashige and Skoog) media for induction of embryogenic callus followed by somatic embryogenesis. Highest callus induction frequency (76 ± 4.8 %) was recorded when petiole explants of in vitro derived plantlets were cultured on B5 medium supplemented with 1...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28328534/clinical-presentation-and-treatment-response-to-diazoxide-in-two-siblings-with-congenital-hyperinsulinism-as-a-result-of-a-novel-compound-heterozygous-abcc8-missense-mutation
#6
Sonya Galcheva, Violeta Iotova, Sian Ellard, Sarah E Flanagan, Irina Halvadzhiyan, Chayka Petrova, Khalid Hussain
BACKGROUND: Congenital hyperinsulinism (CHI) can present with considerable clinical heterogeneity which may be due to differences in the underlying genetic etiology. We present two siblings with hyperinsulinaemic hypoglycaemia (HH) and marked clinical heterogeneity caused by compound heterozygosity for the same two novel ABCC8 mutations. CASE PRESENTATION: The index patient is a 3-year-old boy with hypoglycaemic episodes presenting on the first day of life. HH was diagnosed and treatment with intravenous glucose and diazoxide was initiated...
March 22, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28327509/stability-study-and-a-14-day-oral-dose-toxicity-in-rats-of-plantain-leaf-extract-plantago-lanceolata-l-syrup
#7
Kenza Mansoor, Fadi Qadan, Mathias Schmidt, Eyad Mallah, Wael Abudayyih, Khalid Matalka
Plants have been used since antiquity to treat and prevent diseases. Plantain (Plantago lanceolata L.) is traditionally used for the treatment of the common cold and associated symptoms such as cough. This study was designed to evaluate the oral toxicity of plantain leaf extract-containing syrup. In preparation of the toxicological examination and to ensure the quality of the herbal preparation, analytical methods were developed and validated, and stability testing was performed. Physicochemical and microbial quality, thin layer chromatography patterns and high performance liquid chromatography fingerprints complied with the specifications during the entire period of stability testing...
March 22, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28327380/monetary-costs-of-multiple-medication-use-for-the-treatment-of-individuals-in-recovery-from-chemical-dependency
#8
Corry D Bondi, Clinton P Kassi, Erica L Loadman, Khalid M Kamal, Vincent J Giannetti
No abstract text is available yet for this article.
March 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28327142/exome-sequencing-identified-rare-variants-in-genes-hspg2-and-atp2b4-in-a-family-segregating-developmental-dysplasia-of-the-hip
#9
Sulman Basit, Alia M Albalawi, Essa Alharby, Khalid I Khoshhal
BACKGROUND: Developmental dysplasia of the hip (DDH) is a common pathological condition of the musculoskeletal system in infants which results in a congenital and developmental malformation of the hip joint. DDH is a spectrum of pathologies affecting the infant hip ranging from asymptomatic subtle radiographic signs through mild instability to frank dislocations with acetabular dysplasia. A Saudi family with three affected individuals with DDH was identified and genetic analysis was performed to detect the possible genetic defect(s) underlying DDH in the affected members of the family...
March 21, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28327087/nt5c2-novel-splicing-variant-expands-the-phenotypic-spectrum-of-spastic-paraplegia-spg45-case-report-of-a-new-member-of-thin-corpus-callosum-spg-subgroup
#10
Mahmoud F Elsaid, Khalid Ibrahim, Nader Chalhoub, Ahmed Elsotouhy, Noora El Mudehki, Alice Abdel Aleem
BACKGROUND: Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous group of neurodegenerative diseases. Thin Corpus Callosum (TCC) associated HSP is a distinguished subgroup of complex forms. Purines and pyrimidine, the basic DNA and RNA components, are regulating the cell metabolism, having roles in signal transduction, energy preservation and cellular repair. Genetic defects in nucleotide metabolism related genes have been only recently implicated in brain and neurodegenerative diseases' pathogenesis...
March 21, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28325623/impact-of-body-mass-index-on-survival-outcome-in-patients-with-differentiated-thyroid-cancer
#11
Yousif Al-Ammar, Bader Al-Mansour, Omar Al-Rashood, Mutahir A Tunio, Tahera Islam, Mushabbab Al-Asiri, Khalid Hussain Al-Qahtani
INTRODUCTION: Increased body mass index (BMI) is known to be associated with the high prevalence of Differentiated Thyroid Cancers (DTC); however data on its impact on survival outcome after thyroidectomy and adjuvant therapy is scanty. OBJECTIVE: We aimed to evaluate the impact of BMI on overall survival (OS) and disease free survival (DFS) rates in patients with DTC. METHODS: Between 2000 and 2011, 209 patients with DTC (papillary, follicular, hurthle cell) were treated with thyroidectomy followed by adjuvant radioactive iodine-131 (RAI) therapy and thyroid-stimulating hormone (TSH) suppression...
February 28, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28325600/synthesis-and-anti-cancer-activities-of-new-sulfonamides-4-substituted-triazolyl-nucleosides
#12
Soukaina Alaoui, Maeva Dufies, Mohsine Driowya, Luc Demange, Khalid Bougrin, Guillaume Robert, Patrick Auberger, Gilles Pagès, Rachid Benhida
Nucleoside analogues are among the most known drugs commonly used in antiviral and anticancer chemotherapies. Among them, those featuring a five-membered ring nucleobase are of utmost interest such as the anti-cancer agent AICAR or the anti-viral drug ribavirin. Despite its low activity in vitro in different cell lines, AICAR is under clinical development for several pathologies, thanks to its original mode of action. Indeed, AICAR induced autophagy cell death and is able, following this mechanism, to circumvent resistance to apoptotic drugs including kinase inhibitors currently on the market...
March 9, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28325319/bacterial-cellulose-zinc-oxide-nanocomposites-as-a-novel-dressing-system-for-burn-wounds
#13
Ayesha Khalid, Romana Khan, Mazhar Ul-Islam, Taous Khan, Fazli Wahid
Bacterial cellulose possesses physical and mechanical properties of an ideal wound dressing material but lack of antimicrobial activity limits its biomedical applications. Therefore, in current study, the inherent wound healing characteristics of bacterial cellulose and antimicrobial properties of zinc oxide nanoparticles were combined. The reinforcement (impregnation) of zinc oxide nanoparticles into bacterial cellulose sheets was confirmed through various characterization techniques. The antimicrobial capacity of bacterial cellulose-zinc oxide nanocomposites was tested against common burn pathogens...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28325226/cardiac-pneumonia-acute-mitral-regurgitation-causing-lobar-infiltrate
#14
Ninel Hovnanians, Osama Alsara, Ahmed N Mahmoud, Nayan Agarwal, Sanaullah Mojaddedi, R David Anderson, Mohammad Khalid Mojadidi
No abstract text is available yet for this article.
April 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28323659/stimulus-induced-rhythmic-periodic-or-ictal-discharges-in-coma-incidence-and-interrater-reliability-of-continuous-eeg-after-a-standard-stimulation-protocol-a-prospective-study
#15
Khalid A Alsherbini, Joao Mc-OʼNeil Plancher, David M Ficker, Brandon P Foreman, Opeolu M Adeoye, Jun Ying, Michael D Privitera
PURPOSE: Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs) are often seen during continuous electroencephalographic (cEEG) monitoring in coma. Given their uncertain clinical significance, our prospective study evaluated incidence of SIRPIDs in comatose patients in the neuroscience intensive care unit (NSICU) who underwent a standard stimulation protocol and defined interreader reliability for cEEG. METHODS: Of 146 patients prospectively screened who underwent cEEG during a 6-month period, 53 patients were included and 93 patients were excluded...
March 17, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28323451/phytostabilization-of-heavy-metals-by-the-emergent-macrophyte-vossia-cuspidata-roxb-griff-a-phytoremediation-approach
#16
Tarek M Galal, Fatma A Gharib, Safia M Ghazi, Khalid H Mansour
The present study was conducted to investigate the potential of Vossia cuspidata as a phytoremediator to accumulate heavy metals from polluted water bodies. Thirty-two quadrats, distributed equally in eight sites (six polluted sites along Ismailia canal and two unpolluted sites along the Nile River) were selected seasonally for plant, water and sediment investigations. Winter plants recorded the highest values of shoot height, diameter, and leaf width, but the lowest shoot density. Plants collected in autumn had the lowest values of leaf length, width and area, while those in spring had the highest shoot density, with the lowest shoot height...
March 21, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28322948/development-of-curcumin-loaded-chitosan-polymer-based-nanoemulsion-gel-in-vitro-ex-vivo-evaluation-and-in-vivo-wound-healing-studies
#17
Lydia Thomas, Foziyah Zakira, Mohd Aamir Mirza, Md Khalid Anwer, Farhan Jalees Ahmad, Zeenat Iqbal
In the present study, various nanoemulsions were prepared using Labrafac PG+Triacetin as oil, Tween 80 as a surfactant and polyethylene glycol (PEG 400) as a co-surfactant. The developed nanoemulsions (NE1-NE5) were evaluated for physicochemical characterizations and ex-vivo for skin permeation and deposition studies. The highest skin deposition was observed for NE2 with 46.07% deposition amongst all developed nanoemulsions (NE1-NE5). Optimized nanoemulsion (NE2) had vesicle size of 84.032±0.023nm, viscosity 78...
March 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28319600/early-and-late-factors-impacting-patient-and-graft-outcome-in-pediatric-liver-transplantation-summary-of-an-espghan-monothematic-conference
#18
Valérie A McLin, Upton Allen, Olivia Boyer, John Bucuvalas, Michele Colledan, Maria-Cristina Cuturi, Lorenzo d'Antiga, Dominique Debray, Antal Dezsofi, Jean de Ville de Goyet, Anil Dhawan, Ozlem Durmaz, Christine Falk, Sandy Feng, Björn Fischler, Stéphanie Franchi-Abella, Esteban Frauca, Rainer Ganschow, Stephen Gottschalk, Nedim Hadzic, Loreto Hierro, Simon Horslen, Stefan Hubscher, Vincent Karam, Deirdre Kelly, Britta Maecker-Kolhoff, George Mazariegos, Patrick McKiernan, Anette Melk, Valerio Nobili, Funda Ozgenç, Raymond Reding, Marco Sciveres, Khalid Sharif, Piotr Socha, Christian Toso, Pietro Vajro, Anita Verma, Barbara E Wildhaber, Ulrich Baumann
As pediatric liver transplantation comes of age, experts gathered to discuss current paradigms and define gaps in knowledge warranting research to further improve patient and graft outcomes. Identified areas ripe for collaborative research include understanding the molecular and cellular mechanisms of tolerance and the role of donor-specific antibodies, considering ways to expand donor pool, minimizing long term side effects of immunosuppression, and fine-tuning surgical techniques to minimize biliary and vascular complications...
March 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28319521/warfarin-and-aspirin-versus-warfarin-alone-for-prevention-of-embolic-events-in-patients-with-a-heartmate-ii%C3%A2-left-ventricular-assist-device
#19
Joseph S Van Tuyl, Ian B Hollis, Khalid A Alburikan, Richard Tran, Brian P Murray, Jo E Rodgers, Jason N Katz, Brett C Sheridan
Acquired von Willebrand disease increases bleeding risk in patients implanted with a continuous-flow left ventricular assist device. Lower aspirin doses decrease the risk of bleeding without an increased risk of embolic events. No published studies in the U.S. have compared the incidence of bleeding and thrombotic events between antithrombotic regimens with and without aspirin. A single-center, retrospective analysis was conducted of adult patients implanted with a HM II. Patients received warfarin and aspirin 81 mg daily or warfarin alone...
March 17, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28317970/rheological-and-dynamic-insights-into-an-in-situ-reactive-interphase-with-graft-copolymers-in-multilayered-polymer-systems
#20
Bo Lu, Khalid Lamnawar, Abderrahim Maazouz
We provide rheological and dynamic insights into the role of an in situ reactive interphase with graft copolymers in multilayered polymer systems, using a polyamide-6 (PA6)/maleic anhydride grafted poly(vinylidene fluoride) (PVDF-g-MAH) bilayer as a model. Firstly, the influence of the reactive interphase on macroscopic melt flow behavior was studied. The in situ generated interphase from coupling reactions in bilayers significantly contributed to overall viscoelastic responses in both linear and nonlinear regimes...
March 20, 2017: Soft Matter
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