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https://www.readbyqxmd.com/read/29561956/2-methyl-2-butanol-suppresses-human-retinoblastoma-cells-through-cell-cycle-arrest-and-autophagy
#1
Xiangyun Li, Xiangxiang Zhu, Chong Xu, Jianhua Wu
2-Methyl-2-butanol (MBT) is a chemical compound from the group of alcohols more specifically pentanols, which has shown an excellent anti-cancer activity in our previous study. However, its mechanism of action remains unclear. The present study was designed to investigate the anti-cancer effect of MBT on human retinoblastoma cells. The results showed that the use of MBT leads to HXO-RB44 cell death but is cytotoxic to normal cells at higher concentrations. It showed a dose- as well as a time-dependent inhibition of HXO-RB44 cells...
March 15, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29545747/cardiac-glycoside-glucoevatromonoside-induces-cancer-type-specific-cell-death
#2
Naira F Z Schneider, Claudia Cerella, Jin-Young Lee, Aloran Mazumder, Kyung Rok Kim, Annelise de Carvalho, Jennifer Munkert, Rodrigo M Pádua, Wolfgang Kreis, Kyu-Won Kim, Christo Christov, Mario Dicato, Hyun-Jung Kim, Byung Woo Han, Fernão C Braga, Cláudia M O Simões, Marc Diederich
Cardiac glycosides (CGs) are natural compounds used traditionally to treat congestive heart diseases. Recent investigations repositioned CGs as potential anticancer agents. To discover novel cytotoxic CG scaffolds, we selected the cardenolide glucoevatromonoside (GEV) out of 46 CGs for its low nanomolar anti-lung cancer activity. GEV presented reduced toxicity toward non-cancerous cell types (lung MRC-5 and PBMC) and high-affinity binding to the Na+ /K+ -ATPase α subunit, assessed by computational docking...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29512693/il%C3%A2-17-induces-nsclc-a549-cell-proliferation-via-the-upregulation-of-hmga1-resulting-in-an-increased-cyclin-d1-expression
#3
Chenhui Zhao, Yongting Li, Weiming Zhang, Dan Zhao, Ling Ma, Pei Ma, Fengming Yang, Yingwei Wang, Yongqian Shu, Wen Qiu
Non-small cell lung cancer (NSCLC) is considered to be an inflammation-associated carcinoma. Although interleukin‑17 (IL‑17) production contributes to the proliferation and growth of NSCLC, the mechanisms underlying IL‑17-induced NSCLC cell proliferation have not been fully elucidated. In the present study, by using ELISA and immunohistochemical analyses, we first found that the expression levels of IL‑17, IL‑17 receptor (IL‑17R), high-mobility group A1 (HMGA1) and cyclin D1 were elevated in the samples of patients with NSCLC...
March 7, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29435409/mir-204-5p-suppresses-hepatocellular-cancer-proliferation-by-regulating-homeoprotein-six1-expression
#4
Yi Chu, Mingzuo Jiang, Feng Du, Di Chen, Tao Ye, Bing Xu, Xiaowei Li, Weijie Wang, Zhaoyan Qiu, Haiming Liu, Yongzhan Nie, Jie Liang, Daiming Fan
Fewer than 30% of patients with hepatocellular carcinoma (HCC) are eligible to receive curative therapies, and so a better understanding of the molecular mechanisms of HCC is needed to identify potential therapeutic targets. The role of microRNA (miRNA) in modulating tumour progression has been demonstrated, and therapies targeting miRNA appear promising. miR-204-5p has been shown to function in numerous types of cancer, but its role in HCC remains unclear. In this study, we found that miR-204-5p expression was downregulated in cancerous HCC tissues compared to nontumour tissues...
February 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29403556/pyrroline-5-carboxylate-reductase-1-promotes-proliferation-and-inhibits-apoptosis-in-non-small-cell-lung-cancer
#5
Feng Cai, Yingying Miao, Chenyang Liu, Ting Wu, Simei Shen, Xin Su, Yi Shi
Disordered tumor cell metabolism is involved in the process of tumorigenesis. Proline metabolism is of critical importance for tumor cells, and pyrroline-5-carboxylate reductase 1 (PYCR1), a key proline biosynthesis enzyme, has been reported to be overexpressed in prostate cancer and to promote tumor cell growth in breast cancer. The present study investigated the relationship between PYCR1 and non-small cell lung cancer (NSCLC). The results revealed that PYCR1 was overexpressed in NSCLC tumor tissues compared with adjacent normal tissues...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29397453/synergistic-effect-of-the-pro-apoptosis-peptide-kla-tat-and-the-cationic-anticancer-peptide-hprp-a1
#6
Cuihua Hu, Xiaolong Chen, Yibing Huang, Yuxin Chen
In this study, a peptide-peptide co-administration therapy between hybrid peptide kla-TAT and cationic anticancer peptide HPRP-A1 was designed to increase the anticancer activity of the combination peptides through synergistic effect. kla is a pro-apoptotic peptide which could induce rapid cancer cell apoptosis by disruption the mitochondrial membrane when internalized the cells. To enhance more kla peptides pass through cell membrane, a double improvement strategy was designed by chemically conjugation with cell penetration peptide TAT as well as co-administration with cationic membrane active peptide HPRP-A1, and the double anticancer mechanism of the kla-TAT peptide and HPRP-A1 including membrane disruption and apoptosis induction was verified through in vitro experiments...
February 3, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29306020/a-selective-cyclin-dependent-kinase-4-6-dual-inhibitor-ribociclib-lee011-inhibits-cell-proliferation-and-induces-apoptosis-in-aggressive-thyroid-cancer
#7
Hyun Joo Lee, Woo Kyung Lee, Chan Woo Kang, Cheol Ryong Ku, Yoon Hee Cho, Eun Jig Lee
The RB-E2F1 pathway is an important mechanism of cell-cycle control, and deregulation of this pathway is one of the key factors contributing to tumorigenesis. Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. However, there has been no study to investigate effects of a selective CDK 4/6 inhibitor, Ribociclib (LEE011), in thyroid cancer. Performing Western blotting, we found that RB phosphorylation and the expression of Cyclin D are significantly higher in papillary thyroid cancer (PTC) cell lines as well as anaplastic thyroid cancer (ATC) cell lines, compared with normal thyroid cell line and follicular thyroid cancer cell line...
March 28, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29277505/collagen-prolyl-hydroxylase-3-has-a-tumor-suppressive-activity-in-human-lung-cancer
#8
Yong Li, Yuan Chen, Yunxia Ma, Miljana Nenkov, Daniela Haase, Iver Petersen
Collagen prolyl hydroxylases (P3H) are required for proper collagen biosynthesis. One of the family members P3H3 was downregulated in breast cancer and lymphoma due to DNA methylation. However the role of P3H3 in lung cancer has not yet been elucidated. In this study, we analyzed P3H3 expression in a panel of lung cancer cell lines and primary lung tumors. Epigenetic regulation was explored and the function of P3H3 was investigated by stable transfection and RNA interference. We found that P3H3 was downregulated in 6 out of 10 lung cancer cell lines...
February 1, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29259898/clinical-and-experimental-study-on-angiopoietin-like-protein-8-associated-with-proliferative-diabetic-retinopathy
#9
Chang-Xia Dong, Cai-Ping Song, Chun-Ping Zhang, Mei Dong, Xiu-Rong Gong, He-Ying Gao, Hong Wang
AIM: To confirm the role of angiopoietin-like protein 8 (Angptl 8) in proliferative diabetic retinopathy (PDR). METHODS: The sera and aqueous humor of 10 PDR patients and 10 non-diabetic retinopathy (NDR) patients (idiopathic macular hole patients) were collected and the expression of Angptl 8 was detected by enzyme linked immune-sorbent assay (ELISA). Experimental diabetes mice model was induced with streptozotocin. The expression of glycosylated hemoglobin and Angptl 8 in sera was detected...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29207139/cpne1-silencing-inhibits-the-proliferation-invasion-and-migration-of-human-osteosarcoma-cells
#10
Zhenhuan Jiang, Jiannong Jiang, Bizeng Zhao, Huilin Yang, Yunliang Wang, Shang Guo, Youping Deng, Deyi Lu, Tieliang Ma, Hongwei Wang, Jinzhi Wang
Osteosarcoma (OS) is the most common primary malignancy of the bone affecting children and adolescents. Copine 1 (CPNE1) is a highly conserved calcium-dependent phospholipid-binding protein and may function in regulating signal transduction and membrane trafficking. In the present study, we investigated CPNE1 expression in osteosarcoma tissues and cells, and studied the effects of small interfering RNA (siRNA)-targeting CPNE1 on proliferation, metastasis and chemosensitivity of the osteosarcoma cells. The results demonstrated that CPNE1 was highly expressed in the osteosarcoma tissues and cell lines...
February 2018: Oncology Reports
https://www.readbyqxmd.com/read/28985758/pharmacological-targeting-of-the-ephrin-receptor-kinase-signalling-by-glpg1790-in-vitro-and-in-vivo-reverts-oncophenotype-induces-myogenic-differentiation-and-radiosensitizes-embryonal-rhabdomyosarcoma-cells
#11
Francesca Megiorni, Giovanni Luca Gravina, Simona Camero, Simona Ceccarelli, Andrea Del Fattore, Vincenzo Desiderio, Federica Papaccio, Heather P McDowell, Rajeev Shukla, Antonio Pizzuti, Filip Beirinckx, Philippe Pujuguet, Laurent Saniere, Ellen Van der Aar, Roberto Maggio, Francesca De Felice, Cinzia Marchese, Carlo Dominici, Vincenzo Tombolini, Claudio Festuccia, Francesco Marampon
BACKGROUND: EPH (erythropoietin-producing hepatocellular) receptors are clinically relevant targets in several malignancies. This report describes the effects of GLPG1790, a new potent pan-EPH inhibitor, in human embryonal rhabdomyosarcoma (ERMS) cell lines. METHODS: EPH-A2 and Ephrin-A1 mRNA expression was quantified by real-time PCR in 14 ERMS tumour samples and in normal skeletal muscle (NSM). GLPG1790 effects were tested in RD and TE671 cell lines, two in vitro models of ERMS, by performing flow cytometry analysis, Western blotting and immunofluorescence experiments...
October 6, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28948561/relationship-between-the-contents-of-cyclins-cyclin-dependent-kinases-and-their-inhibitors-in-whole-blood-mononuclear-leukocytes-during-the-postclinical-stage-of-community-acquired-pneumonia-under-the-influence-of-1-ghz-microwaves
#12
V G Zilov, A A Khadartsev, I V Terekhov, S S Bondar'
The contents of cyclins A1, B1, E1, and D1, cyclin-dependent kinases 2 and 4 (CDK2 and CDK4), cyclin-dependent kinase 2C inhibitor (p18), and cyclin-dependent kinase 1C inhibitor (p57) in whole blood mononuclear cells of practically healthy donors and convalescents from community-acquired pneumonia were measured after cell exposure to low-intensity electromagnetic radiation of 1 GHz. The level of cyclins A1, D1, and B1, p57, and p18 proteins, and CDK2 was reduced in convalescents, while the content of cyclin B1 was elevated in both groups...
September 26, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28870911/sunitinib-inhibits-breast-cancer-cell-proliferation-by-inducing-apoptosis-cell-cycle-arrest-and-dna-repair-while-inhibiting-nf-%C3%AE%C2%BAb-signaling-pathways
#13
Hesham M Korashy, Zaid H Maayah, Fawaz E Al Anazi, Abdulaziz M Alsaad, Ibrahim O Alanazi, Osamah M Belali, Fahad O Al-Atawi, Aws Alshamsan
The tyrosine kinase inhibitor sunitinib was recently approved for use against gastrointestinal stromal tumors and advanced renal cell carcinoma. Yet, the protective effect of sunitinib against breast cancer has been poorly investigated. In this study, we investigated the antiproliferative and apoptogenic effects of sunitinib and the possible mechanism involved against the MCF7 human breast cancer cell line. Treatment of MCF7 cells with sunitinib caused concentration-dependent cell growth suppression due to apoptosis...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28803881/cell-specific-and-dose-dependent-effects-of-pahs-on-proliferation-cell-cycle-and-apoptosis-protein-expression-and-hormone-secretion-by-placental-cell-lines
#14
Eliza Drwal, Agnieszka Rak, Adam Grochowalski, Tomasz Milewicz, Ewa Lucja Gregoraszczuk
In the preset study we measured the concentrations of 16 priority PAHs in maternal blood and placental tissue by using the GC-MS/MS system, and investigated the effects of selected PAHs (naphthalene, anthracene, phenanthrene, pyrene) and mixtures on BeWo and JEG-3 human placental cell line proliferation (Alamar Blue), cytotoxicity (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (XTT), lactate dehydrogenase (LDH), acid phosphatase (AP), endocrine activity (progesterone and estradiol secretion) and apoptosis (cyclin A1, cyclin D2, cdk 2, cdk 4, Bcl-xl, Bax, and caspase-3 protein expression)...
October 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28777434/bifunctional-role-of-ephrin-a1-eph-system-in-stimulating-cell-proliferation-and-protecting-cells-from-cell-death-through-the-attenuation-of-er-stress-and-inflammatory-responses-in-bovine-mammary-epithelial-cells
#15
Minkyung Kang, Wooyoung Jeong, Hyocheol Bae, Whasun Lim, Fuller W Bazer, Gwonhwa Song
Structural and functional development of the mammary gland is constant in the mammary gland life cycle. Eph receptors and their ligands, ephrins, control events through cell-to-cell interactions during embryonic development, and adult tissue homeostasis; however, little information on participation of ephrin A1, a representative ligand of the Eph receptor, in the development and function of normal mammary glands is known. In this study, we demonstrated functional effects of the ephrin A1-Eph system and mechanisms of its action on bovine mammary epithelial (MAC-T) cells...
March 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28737823/overexpression-of-non%C3%A2-smc-condensin%C3%A2-i-complex-subunit%C3%A2-g-serves-as-a-promising-prognostic-marker-and-therapeutic-target-for-hepatocellular-carcinoma
#16
Wanwei Liu, Bo Liang, Hongliang Liu, Yong Huang, Xiangbao Yin, Fan Zhou, Xin Yu, Qian Feng, Enliang Li, Zhenhong Zou, Linquan Wu
The non‑SMC condensin I complex subunit G (NCAPG) that organizes the coiling topology of individual chromatids, represents an overexpressed antigen in various types of cancer, and also contributes to restructuring chromatin into rod‑shaped mitotic chromosomes and ensuring the segregation of sister chromatid during cell division. In this study, we investigated the association between NCAPG expression and the biological behavior of hepatocellular carcinoma (HCC) to further explore the potential of NCAPG as a therapeutic target...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28670110/cryptotanshinone-induces-cell-cycle-arrest-and-apoptosis-through-the-jak2-stat3-and-pi3k-akt-nf%C3%AE%C2%BAb-pathways-in-cholangiocarcinoma-cells
#17
Fayong Ke, Zheng Wang, Xiaoling Song, Qiang Ma, Yunping Hu, Lin Jiang, Yijian Zhang, Yingbin Liu, Yong Zhang, Wei Gong
BACKGROUND: Cholangiocarcinoma (CCA) is the most common biliary tract malignancy in the world with high resistance to current chemotherapies and extremely poor prognosis. The main objective of this study was to investigate the inhibitory effects of cryptotanshinone (CTS), a natural compound isolated from Salvia miltiorrhiza Bunge, on CCA both in vitro and in vivo and to explore the underlying mechanisms of CTS-induced apoptosis and cell cycle arrest. METHODS: The anti-tumor activity of CTS on HCCC-9810 and RBE cells was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay and colony forming assays...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28627629/reducing-autophagy-and-inducing-g1-phase-arrest-by-aloperine-enhances-radio-sensitivity-in-lung-cancer-cells
#18
Zhijie Xu, Yuanliang Yan, Shuangshuang Zeng, Long Qian, Shuang Dai, Lingfang Xiao, Lin Wang, Xue Yang, Yi Xiao, Zhicheng Gong
Aloperine (ALO), an isolated alkaloid from the leaves of Sophora alopecuroides (S. alopecuroides), has been suggested to exhibit anti-inflammatory and antitumor properties, and has been traditionally used to treat various diseases, including cancers. However, little is known about the effects of ALO on the radio-sensitivity of lung cancer cells. In the present study, we confirmed that agent ALO inhibits cell growth, promotes cell aopotosis and induces G1 phase arrest and consequently enhanced the radio-sensitivity in radio-resistant lung cancer cells A549/IR...
June 19, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28608720/diagnostic-algorithm-of-common-mature-b-cell-lymphomas-by-immunohistochemistry
#19
REVIEW
Huan-You Wang, Youli Zu
CONTEXT: - Different types of mature B-cell lymphomas, including plasma cell neoplasms, exhibit distinct immunohistochemical profiles, which enable them to be correctly diagnosed. However, except for rare examples of lymphoma-specific immunohistochemistry, such as cyclin D1 in mantle cell lymphoma and annexin A1 in hairy cell leukemia, immunohistochemical profiles of mature B-cell lymphomas overlap and lack specificity. OBJECTIVES: - To systemically review immunohistochemical features associated with commonly encountered mature B-cell lymphomas based on the presence or absence of CD5 and CD10; to review the immunophenotypic profile of plasma cells derived from plasma cell myelomas and B-cell lymphomas; and to review a group of rare, aggressive B-cell lymphomas with antigen expression features of plasma cells...
September 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28569402/lrwd1-regulates-microtubule-nucleation-and-proper-cell-cycle-progression-in-the-human-testicular-embryonic-carcinoma-cells
#20
Chia-Yih Wang, Yu-Han Hong, Jhih-Siang Syu, Yung-Chieh Tsai, Xiu-Ying Liu, Ting-Yu Chen, Yin-Mei Su, Pao-Lin Kuo, Yung-Ming Lin, Yen-Ni Teng
Leucine-rich repeats and WD repeat domain containing protein 1 (LRWD1) is a testis-specific protein that mainly expressed in the sperm neck where centrosome is located. By using microarray analysis, LRWD1 is identified as a putative gene that involved in spermatogenesis. However, its role in human male germ cell development has not been extensively studied. When checking in the semen of patients with asthenozoospermia, teratozoospermia, and asthenoteratozoospermia, the level of LRWD1 in the sperm neck was significantly reduced with a defective neck or tail...
January 2018: Journal of Cellular Biochemistry
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