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https://www.readbyqxmd.com/read/28230003/risk-stratification-for-disease-progression-in-pt3-prostate-cancer-after-robot-assisted-radical-prostatectomy
#1
Jeong Hee Hong, Young Suk Kwon, Isaac Yi Kim
The aim of this study is to identify optimal patients for adjuvant radiation therapy (ART) in pT3 prostate cancer. The role of ART for patients with adverse pathologic features after radical prostatectomy (RP) has been demonstrated, but over- or under-treatment remains a significant concern. Two-hundred and five patients with pT3N0M0 who underwent robot-assisted RP without ART were analyzed. Multivariate Cox proportional regression analyses were used to identify predictors of biochemical recurrence (BCR) and clinical progression (CP)...
February 21, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28227182/strategies-to-improve-stimulation-efficiency-for-retinal-prostheses
#2
Navya S Davuluri, Kiran Nimmagadda, Artin Petrossians, Mark S Humayun, James D Weiland, Navya S Davuluri, Kiran Nimmagadda, Artin Petrossians, Mark S Humayun, James D Weiland, Mark S Humayun, Kiran Nimmagadda, Navya S Davuluri, James D Weiland, Artin Petrossians
Retinitis Pigmentosa (RP) is a degenerative disease of the retina that leads to vision loss. Retinal prostheses are being developed in order to restore functional vision in patients suffering from RP. We conducted in-vivo experiments in order to identify strategies to efficiently stimulate the retina. We electrically stimulated the retina and measured electrically evoked potentials (EERs) from the superior colliculus of rats. We compared the strength of EERs when voltage-controlled and current-controlled pulses of varying pulse width and charge levels were applied to the retina...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227076/analysis-of-blood-pressure-signal-in-patients-with-different-ventricular-ejection-fraction-using-linear-and-non-linear-methods
#3
Andres Arcentales, Patricio Rivera, Pere Caminal, Andreas Voss, Antonio Bayes-Genis, Beatriz F Giraldo, Andres Arcentales, Patricio Rivera, Pere Caminal, Andreas Voss, Antonio Bayes-Genis, Beatriz F Giraldo, Pere Caminal, Antonio Bayes-Genis, Andres Arcentales, Patricio Rivera, Beatriz F Giraldo, Andreas Voss
Changes in the left ventricle function produce alternans in the hemodynamic and electric behavior of the cardiovascular system. A total of 49 cardiomyopathy patients have been studied based on the blood pressure signal (BP), and were classified according to the left ventricular ejection fraction (LVEF) in low risk (LR: LVEF>35%, 17 patients) and high risk (HR: LVEF≤35, 32 patients) groups. We propose to characterize these patients using a linear and a nonlinear methods, based on the spectral estimation and the recurrence plot, respectively...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225991/prevalence-of-musculoskeletal-symptoms-in-obese-patients-candidates-for-bariatric-surgery-and-its-impact-on-health-related-quality-of-life
#4
Gabriela Calenzani, Fabiana Ferreira Dos Santos, Veronica Lourenço Wittmer, Grace Kelly Filgueiras Freitas, Flávia Marini Paro
Objective: This study was designed to identify the major musculoskeletal symptoms of individuals with obesity, to assess their health-related quality of life, and to evaluate the correlation between the musculoskeletal symptoms and the individuals' health-related quality of life. Materials and methods: Cross-sectional study. Instruments used: "Nordic Musculoskeletal Questionnaire" and "The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36)"...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225724/outer-retinal-tubulation-in-retinal-dystrophies
#5
Imoro Z Braimah, Sunila Dumpala, Jay Chhablani
BACKGROUND/PURPOSE: To evaluate the occurrence and characteristics of outer retinal tubulation (ORT) in an Indian population with retinal dystrophies. METHODS: In this retrospective study, 309 eyes of 157 patients with retinal dystrophies including retinitis pigmentosa (RP, 183 eyes), Stargardt disease (STGD, 93 eyes) and Best disease (33 eyes) were reviewed. The demographic details, clinical data including visual acuity, treatment history and good quality spectral domain optical coherence tomography (SD-OCT) scans were collected...
March 2017: Retina
https://www.readbyqxmd.com/read/28224248/vis-nir-spectroscopy-with-moving-window-pls-method-applied-to-rapid-analysis-of-whole-blood-viscosity
#6
Jiemei Chen, Zhiwei Yin, Yi Tang, Tao Pan
A rapid analytical method of human whole blood viscosity with low, medium, and high shear rates [WBV(L), WBV(M), and WBV(H), respectively] was developed using visible and near-infrared (Vis-NIR) spectroscopy combined with a moving-window partial least squares (MW-PLS) method. Two groups of peripheral blood samples were collected for modeling and validation. Separate analytical models were established for male and female groups to avoid interference in different gender groups and improve the homogeneity and prediction accuracy...
February 21, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28223972/changes-in-metabolically-active-bacterial-community-during-rumen-development-and-their-alteration-by-rhubarb-root-powder-revealed-by-16s-rrna-amplicon-sequencing
#7
Zuo Wang, Chijioke Elekwachi, Jinzhen Jiao, Min Wang, Shaoxun Tang, Chuanshe Zhou, Zhiliang Tan, Robert J Forster
The objective of this present study was to explore the initial establishment of metabolically active bacteria and subsequent evolution in four fractions: rumen solid-phase (RS), liquid-phase (RL), protozoa-associated (RP), and epithelium-associated (RE) through early weaning and supplementing rhubarb root powder in 7 different age groups (1, 10, 20, 38, 41, 50, and 60 d) during rumen development. Results of the 16S rRNA sequencing based on RNA isolated from the four fractions revealed that the potentially active bacterial microbiota in four fractions were dominated by the phyla Proteobacteria, Firmicutes, and Bacteroidetes regardless of different ages...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28222734/diabetes-and-beta-adrenergic-blockage-are-risk-factors-for-metastatic-prostate-cancer
#8
Malte Krönig, Christian Haverkamp, Antonia Schulte, Laura Heinicke, Kathrin Schaal, Vanessa Drendel, Martin Werner, Ulrich Wetterauer, Wolfgang Schultze-Seemann, Cordula Annette Jilg
BACKGROUND: We evaluated the influence of comorbidity inferred risks for lymph node metastasis (pN1) and positive surgical margins (R1) after radical prostatectomy in order to optimize pretherapeutic risk classification. We analyzed 454 patients after radical prostatectomy (RP) between 2009 and 2014. Comorbidities were defined by patients' medication from our electronic patient chart and stratified according to the ATC WHO code. Endpoints were lymph node metastasis (pN1) and positive surgical margins (R1)...
February 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28222175/factors-associated-with-post-diagnosis-pregnancies-in-women-living-with-hiv-in-the-south-of-brazil
#9
Luciana Barcellos Teixeira, Flávia Bulegon Pilecco, Álvaro Vigo, Maria de Lourdes Drachler, José Carlos de Carvalho Leite, Daniela Riva Knauth
OBJECTIVES: To analyze the factors associated with the occurrence of pregnancies after the diagnosis of infection by HIV. METHODS: Cross-sectional study with women of a reproductive age living with HIV/AIDS cared for in the public services of the city of Porto Alegre, in southern Brazil. The data was analyzed from a comparison between two groups: women with and women without pregnancies after the diagnosis of HIV. Poisson regression models were used to estimate the reasons of prevalence (RP)...
2017: PloS One
https://www.readbyqxmd.com/read/28221344/chemoproteomic-profiling-and-discovery-of-protein-electrophiles-in-human-cells
#10
Megan L Matthews, Lin He, Benjamin D Horning, Erika J Olson, Bruno E Correia, John R Yates, Philip E Dawson, Benjamin F Cravatt
Activity-based protein profiling (ABPP) serves as a chemical proteomic platform to discover and characterize functional amino acids in proteins on the basis of their enhanced reactivity towards small-molecule probes. This approach, to date, has mainly targeted nucleophilic functional groups, such as the side chains of serine and cysteine, using electrophilic probes. Here we show that 'reverse-polarity' (RP)-ABPP using clickable, nucleophilic hydrazine probes can capture and identify protein-bound electrophiles in cells...
March 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28220652/etiology-and-management-of-earlier-versus-later-biochemical-recurrence-following-retropubic-radical-prostatectomy
#11
Elton Llukani, Herbert Lepor
Approximately 100,000 radical prostatectomies (RP) are performed annually in the US with the intent to cure clinically localized prostate cancer. Oncological control following RP is assessed by monitoring serum PSA levels. By consensus, a PSA exceeding 0.2 ng/mL is considered the threshold for a biochemical recurrence (BCR) following RP (3). BCR often predates radiographic and clinical evidence of disease recurrence by many years (4-6). This article is protected by copyright. All rights reserved.
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220550/metabolomic-profiling-in-umbilical-venous-plasma-reveals-effects-of-dietary-rumen-protected-arginine-or-n-carbamylglutamate-supplementation-in-nutrient-restricted-hu-sheep-during-pregnancy
#12
L Sun, H Zhang, Y Fan, Y Guo, G Zhang, H Nie, F Wang
Maternal nutrient restriction during pregnancy is a major problem worldwide for human and animal production. Arginine (Arg) is critical to health, growth and reproduction. N-carbamylglutamate (NCG), a key enzyme in arginine synthesis, is not extensively degraded in rumen. The aim of this study was to investigate ameliorating effects of rumen-protected arginine (RP-Arg) and NCG supplementation on dietary in undernourished Hu sheep during gestation. From day 35 to 110 of gestation, 32 Hu ewes carrying twin foetuses were randomly divided into four groups: a control (CG) group (n = 8; fed 100% National Research Council (NRC) requirements for pregnant sheep), a nutrient-restricted (RG) group (n = 8; fed 50% NRC requirements, which included 50% mineral-vitamin mixture) and two treatment (Arg and NCG) groups (n = 8; fed 50% NRC requirements supplemented with 20 g/day RP-Arg or 5 g/day NCG, which included 50% mineral-vitamin mixture)...
February 20, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28219796/simultaneous-quantitation-of-abiraterone-enzalutamide-n-desmethyl-enzalutamide-and-bicalutamide-in-human-plasma-by-lc-ms-ms
#13
Kyu-Pyo Kim, Robert A Parise, Julianne L Holleran, Lionel D Lewis, Leonard Appleman, Nielka van Erp, Michael J Morris, Jan H Beumer
Inhibiting the androgen receptor (AR) pathway is an important clinical strategy in metastatic prostate cancer. Novel agents including abiraterone acetate and enzalutamide have been shown to prolong life in men with metastatic, castration-resistant prostate cancer (mCRPC). To evaluate the pharmacokinetics of AR-targeted agents, we developed and validated an LC-MS/MS assay for the quantitation of enzalutamide, N-desmethyl enzalutamide, abiraterone and bicalutamide in 0.05mL human plasma. After protein precipitation, chromatographic separation was achieved with a Phenomenex Synergi Polar-RP column and a linear gradient of 0...
February 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28219525/acclimation-strategy-of-rhodopseudomonas-palustris-to-high-light-irradiance
#14
Dayana Muzziotti, Alessandra Adessi, Cecilia Faraloni, Giuseppe Torzillo, Roberto De Philippis
The ability of Rhodopseudomonas palustris cells to rapidly acclimate to high light irradiance is an essential issue when cells are grown under sunlight. The aim of this study was to investigate the photo-acclimation process in Rhodopseudomonas palustris 42OL under different culturing conditions: (i) anaerobic (AnG), (ii) aerobic (AG), and (iii) under H2-producing (HP) conditions both at low (LL) and high light (HL) irradiances. The results obtained clearly showed that the photosynthetic unit was significantly affected by the light irradiance at which Rp...
April 2017: Microbiological Research
https://www.readbyqxmd.com/read/28217445/the-controversy-surrounding-penile-rehabilitation-after-radical-prostatectomy
#15
REVIEW
Jonathan Clavell-Hernández, Run Wang
Radical prostatectomy (RP) techniques have been refined in the last few decades. Despite nerve-sparing surgery, erectile dysfunction (ED) still seems to be affecting more than half of patients undergoing RP. Penile rehabilitation consists of understanding the mechanisms that affect erectile function (EF) and utilizing pharmacologic agents, devices or interventions to promote male sexual function before and after any insult to the penile erectile physiologic axis. There currently is a limited amount of clinical trials that assess treatments with the goal of recovering post-prostatectomy EF...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28216884/chemical-components-from-aloe-and-their-inhibition-of-indoleamine-2-3-dioxygenase
#16
Ya Nan Sun, Lin Ying Li, Wei Li, Jong Seong Kang, Inkyu Hwang, Young Ho Kim
BACKGROUND: In Korea, Aloe is routinely ingested as a traditional medicine or as a component of health beverages. OBJECTIVE: To research the inhibition of indoleamine 2, 3-dioxygenase (IDO) activities of components from Aloe. MATERIALS AND METHODS: the compounds were isolated by a combination of silica gel and YMC Rp-18 column chromatography, and their structures were identified by analysis of spectroscopic data (1D, 2D-NMR, and MS). All of the isolated compounds were examined for their ability to inhibit IDO, which actively suppresses immune functions by catalyzing the rate limiting reaction in the conversion of tryptophan to kynurenine...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28216676/fractalkine-cx3cr1-signaling-is-critical-for-progesterone-mediated-neuroprotection-in-the-retina
#17
Sarah L Roche, Alice C Wyse-Jackson, Ana M Ruiz-Lopez, Ashleigh M Byrne, Thomas G Cotter
Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss and blindness. We have previously shown in the rd10 mouse model of RP, that rd10 microglia drive degeneration of viable neurons. Norgestrel, a progesterone analogue, primes viable neurons against potential microglial damage. In the current study we wished to investigate this neuroprotective effect further. We were particularly interested in the role of fractalkine-CX3CR1 signaling, previously shown to mediate photoreceptor-microglia crosstalk and promote survival in the rd10 retina...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216641/targeted-rp9-ablation-and-mutagenesis-in-mouse-photoreceptor-cells-by-crispr-cas9
#18
Ji-Neng Lv, Gao-Hui Zhou, Xuejiao Chen, Hui Chen, Kun-Chao Wu, Lue Xiang, Xin-Lan Lei, Xiao Zhang, Rong-Han Wu, Zi-Bing Jin
Precursor messenger RNA (Pre-mRNA) splicing is an essential biological process in eukaryotic cells. Genetic mutations in many spliceosome genes confer human eye diseases. Mutations in the pre-mRNA splicing factor, RP9 (also known as PAP1), predispose autosomal dominant retinitis pigmentosa (adRP) with an early onset and severe vision loss. However, underlying molecular mechanisms of the RP9 mutation causing photoreceptor degeneration remains fully unknown. Here, we utilize the CRISPR/Cas9 system to generate both the Rp9 gene knockout (KO) and point mutation knock in (KI) (Rp9, c...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216329/oncological-and-functional-outcomes-after-radical-prostatectomy-for-high-or-very-high-risk-prostate-cancer-european-validation-of-the-current-nccn-guideline
#19
Raisa S Pompe, Pierre I Karakiewicz, Zhe Tian, Philipp Mandel, Thomas Steuber, Thorsten Schlomm, Georg Salomon, Markus Graefen, Hartwig Huland, Derya Tilki
PURPOSE: To validate the current NCCN-classification of very high-risk (VHR) patients and compare the pathological, functional and oncological outcomes between surgically treated high- (HR) and VHR patients. MATERIALS & METHODS: We retrospectively analyzed 4041 patients stratified into high- or VHR who underwent RP between 1992-2016. Kaplan-Meier as well as multivariable logistic and Cox regression analyses compared outcomes between the two groups. RESULTS: After RP, the rate of adverse pathological features was higher in 1369 VHR vs...
February 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28216327/combined-whole-body-and-multi-parametric-prostate-mri-as-a-single-step-approach-for-the-simultaneous-assessment-of-local-recurrence-and-metastatic-disease-after-radical-prostatectomy
#20
Nicola L Robertson, Evis Sala, Matthias Benz, Jonathan Landa, Peter Scardino, Howard I Scher, Hedvig Hricak, Hebert A Vargas
PURPOSE: To report our initial experience using "whole body and dedicated prostate (WB+P)" MRI as a single exam for the assessment of local recurrence and metastatic disease in patients with suspected recurrent prostate cancer (PCa) after radical prostatectomy (RP). MATERIALS AND METHODS: IRB-approved retrospective single-center study. 76 consecutive patients with clinically suspected recurrent PCa following RP underwent combined WB+P-MRI in a single session (10/2014-01/2016)...
February 16, 2017: Journal of Urology
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