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https://www.readbyqxmd.com/read/27904077/synthesis-characterization-and-evaluation-of-thiazolidine-derivatives-of-cysteine-for-suppressing-eumelanin-production
#1
Yusuke Amino, Yoshinobu Takino, Megumi Kaneko, Fumie Ookura, Mai Yamamoto, Tatsuki Kashiwagi, Keiji Iwasaki
In the pathway of melanin biosynthesis, cysteine (Cys) is utilized for the synthesis of pheomelanin. Accordingly, Cys is considered to suppress the formation of brown-black eumelanin. Although attempts have been made to utilize Cys and its derivatives as skin-whitening agents, their instability and odor hinders their application as a cosmetic agent. Herein, N-acetyl-2-methylthiazolidine-2,4-dicarboxylic acid ethyl ester (AcCP2Et) was proposed as a candidate for a stable and prolonged-release derivative of Cys to inhibit dopachrome formation after its degradation in melanocytes...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27899520/is-adherence-to-the-american-college-of-chest-physicians-recommended-anticoagulation-treatment-duration-associated-with-different-outcomes-among-patients-with-venous-thromboembolism
#2
Alex C Spyropoulos, Ron Preblick, Winghan J Kwong, Melissa Lingohr-Smith, Jay Lin
Clinical and economic outcomes associated with venous thromboembolism (VTE) patient adherence to the American College of Chest Physicians (ACCP) anticoagulant (AC) treatment guidelines are incompletely understood. Patients with ≥1 inpatient or ≥2 separate outpatient claims for deep vein thrombosis and/or pulmonary embolism, based on International Classification of Diseases, Ninth Revision, Clinical Modification codes, were identified from the IMS PharMetrics Plus database. Patients had continuous insurance coverage for 12 months before (baseline) and after (follow-up) the index event (first VTE claim) but no baseline VTE claims...
November 28, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27858553/cross-sectional-evaluation-of-periodontal-status-microbiological-and-rheumatoid-parameters-in-a-large-cohort-of-patients-with-rheumatoid-arthritis
#3
Jan Schmickler, Annegret Rupprecht, Susann Patschan, Daniel Patschan, Gerhard A Müller, Rainer Haak, Rainer F Mausberg, Gerhard Schmalz, Tanja Kottmann, Dirk Ziebolz
BACKGROUND: This study evaluates periodontal conditions and microbiological findings and their influence on rheumatological disease parameters in patients with rheumatoid arthritis (RA). METHODS: 168 RA-patients were included. A healthy control group (HC, n=168) was composed according to age, gender and smoking habits. Rheumatological data (duration of illness, DAS28, RF, aCCP, medications) were extracted from patients' records. Dental examination included: dental findings (DMF-T), gingival inflammation (PBI), periodontal status (probing depth [PD], attachment loss [AL])...
November 18, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27804864/immunology-rheumatology-approach-to-sudden-sensorineural-hearing-loss
#4
Mohsen Rajati, Massod Saghafi, Houshang Rafatpanah, Bashir Rasoulian, Shirin Irani, Mohammadsaleh Soltankhah
BACKGROUND: Sensorineural hearing loss (SNHL) and vestibular dysfunction have been described in various autoimmune disorders and systemic vasculitides. A high prevalence of SNHL is reported to occur in established rheumatologic diseases; however, immunologic and rheumatologic disorders make up a small proportion of patients with sudden sensorineural hearing loss (SSNHL). OBJECTIVE: This prospective study was carried out in order to determine the prevalence of rheumatologic and immunologic disorders in patients with SSNHL in Northeast Iran...
October 29, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27791276/the-2016-accp-pharmacotherapy-didactic-curriculum-toolkit
#5
Terry L Schwinghammer, Andrew J Crannage, Eric G Boyce, Bridget Bradley, Alyssa Christensen, Henry M Dunnenberger, Michelle Fravel, Holly Gurgle, Drayton A Hammond, Jennifer Kwon, Douglas Slain, Kurt A Wargo
The 2016 American College of Clinical Pharmacy (ACCP) Educational Affairs Committee was charged with updating and contemporizing ACCP's 2009 Pharmacotherapy Didactic Curriculum Toolkit. The toolkit has been designed to guide schools and colleges of pharmacy in developing, maintaining, and modifying their curricula. The 2016 committee reviewed the recent medical literature and other documents to identify disease states that are responsive to drug therapy. Diseases and content topics were organized by organ system, when feasible, and grouped into tiers as defined by practice competency...
October 28, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27770350/impact-of-clinical-pharmacy-interventions-on-medication-error-nodes
#6
Nibal R Chamoun, Rony Zeenny, Hanine Mansour
Background Pharmacists' involvement in patient care has improved the quality of care and reduced medication errors. However, this has required a lot of work that could not have been accomplished without documentation of interventions. Several means of documenting errors have been proposed in the literature but without a consistent comprehensive process. Recently, the American College of Clinical Pharmacy (ACCP) recognized that pharmacy practice lacks a consistent process for direct patient care and discussed several options for a pharmaceutical care plan, essentially encompassing medication therapy assessment, development and implementation of a pharmaceutical care plan and finally evaluation of the outcome...
December 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27765053/impact-of-recent-guideline-changes-on-aspirin-prescribing-after-knee-arthroplasty
#7
Sarav S Shah, Alexander M Satin, James R Mullen, Sara Merwin, Mark Goldin, Nicholas A Sgaglione
BACKGROUND: Prior to 2012, the American Academy of Orthopaedic Surgeons (AAOS) and American College of Chest Physicians (ACCP) differed in their recommendations for postoperative pharmacologic venous thromboembolism prophylaxis (VTEP) after total joint arthroplasty. More specifically, aspirin (ASA) monotherapy was not endorsed by the ACCP as an acceptable prophylaxis. In 2012, the ACCP supported ASA monotherapy compared with no prophylaxis. Our aim was to investigate the impact of the convergence of ACCP and AAOS recommendations on surgeon prescribing patterns after knee arthroplasty (KA)...
October 20, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27752864/adherence-to-thromboprophylaxis-guidelines-in-elderly-patients-with-hospital-acquired-venous-thromboembolism-a-case-control-study
#8
Jason Suh, Amishi Desai, Anish Desai, Josephine Dela Cruz, Anusiyanthan Mariampillai, Alexander Hindenburg
Venous thromboembolism (VTE) remains the number one preventable cause of hospital acquired mortality and morbidity. Each year, more than 12 million patients are at risk for VTE. The delivery of appropriate and timely VTE prophylaxis is still suboptimal in many healthcare institutions and can lead to increased readmissions, morbidity, as well as costs. To clarify this issue further, we performed a retrospective case control study at our institution to determine if poor adherence to the VTE prophylaxis guidelines could lead to an increase in VTE events...
October 17, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27713883/epidemiologic-trends-of-sepsis-in-western-countries
#9
Alejandro Suarez De La Rica, Fernando Gilsanz, Emilio Maseda
Since the American College of Chest Physicians (ACCP) and the Society of Critical care Medicine (SCCM) published the first consensus definition of syndromes related to sepsis in 1992, the knowledge of epidemiology of sepsis has clearly improved, although no prospective studies have been performed to analyse the incidence of sepsis in general population. There are differences in epidemiologic trends in sepsis between western countries and low-income and middle-income countries. In the United States (US), most of epidemiologic studies have been based on large, administrative databases, reporting an increase in the incidence of severe sepsis over years...
September 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27699759/severe-sepsis-in-the-icu-is-often-missing-in-hospital-discharge-codes
#10
S B Wilhelms, S M Walther, F Huss, F Sjöberg
BACKGROUND: Different International Classification of Diseases (ICD)-based code abstraction strategies have been used when studying the epidemiology of severe sepsis. The aim of this study was to compare three previously used ICD code abstraction strategies to the American College of Chest Physicians/Society of Critical Care Medicine (ACCP/SCCM) consensus criteria for severe sepsis, in a setting of intensive care patients. METHODS: All patients (≥ 18 years of age) with severe sepsis according to the ACCP/SCCM criteria registered in the Swedish Intensive Care Registry (2005-2009) were included in the study...
October 4, 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27685322/deficits-awareness-in-persons-with-mild-cognitive-impairment-and-family-care-partners
#11
Jyoti Savla, Zhe Wang, Karen A Roberto, Rosemary Blieszner
Introduction: An emerging perspective of dyadic coping with chronic illness argues that concordance in the appraisal of illness is crucial for collaborative attempts at seeking information, making treatment decisions, and planning for long-term management of the illness and psychological and physical adjustments of both the care provider and care recipient. The present study examined whether persons with mild cognitive impairment (PwMCIs) and their family care partners (CPs) exhibited concordance in their awareness of deficits in the PwMCIs...
September 29, 2016: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/27652114/venous-thromboembolism-prophylaxis-in-patients-undergoing-abdominal-and-pelvic-cancer-surgery-adherence-and-compliance-to-accp-guidelines-in-dionys-registry
#12
Negib Geahchan, Melkart Basile, Maroon Tohmeh
BACKGROUND: Venous thromboembolism (VTE) is a major health care problem resulting in significant mortality, morbidity and increase in medical expenses. Patients with malignant diseases represent a high risk population for VTE. The American College of Chest Physicians (ACCP) proposed, since 1986, prophylaxis guidelines that are unequally respected in surgical practice. METHODS: DIONYS is a multinational, longitudinal and non-interventional registry including patients having undergone abdominal or pelvic surgery for cancer in Latin America, Africa and the Middle East...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27614002/chronic-cough-due-to-gastroesophageal-reflux-in-adults-chest-guideline-and-expert-panel-report
#13
Peter J Kahrilas, Kenneth W Altman, Anne B Chang, Stephen K Field, Susan M Harding, Andrew P Lane, Kaiser Lim, Lorcan McGarvey, Jaclyn Smith, Richard S Irwin
BACKGROUND: We updated the 2006 ACCP clinical practice guidelines for management of reflux-cough syndrome. METHODS: Two PICO questions were addressed by systematic review: 1) can therapy for gastroesophageal reflux improve or eliminate cough in adults with chronic and persistently troublesome cough? and 2) are there minimal clinical criteria to guide practice in determining that chronic cough is likely to respond to therapy for gastroesophageal reflux? RESULTS: We found no high quality studies pertinent to either question...
September 7, 2016: Chest
https://www.readbyqxmd.com/read/27582411/the-pict-%C3%A2-test-is-a-reliable-alternative-to-the-activated-partial-thromboplastin-time-in-unfractionated-heparin-therapy-management-results-from-a-multicenter-study
#14
A C Brisset, A Ferrández, M Krause, S Rathbun, R Marlar, W Korte
: Essentials Activated partial thromboplastin time (APTT) or anti-Xa tests are used to monitor heparin. Prothrombinase-induced Clotting Time (PiCT) was compared to APTT in a clinical study. PiCT shows higher correlation to anti-Xa than APTT does and is more comparable between centers. PiCT demonstrates significantly higher accuracy and reliability than APTT in heparin monitoring. SUMMARY: Background Unfractionated heparin (UFH) is still a commonly used anticoagulant for prevention and treatment of thromboembolism in a variety of situations...
September 1, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27559946/five-year-follow-up-of-pulmonary-embolism-under-anticoaugulation-the-pisa-peet-pulmonary-embolism-extension-therapy-study
#15
Letizia Marconi, Laura Carrozzi, Ferruccio Aquilini, Alessandro Celi, Francesco Pistelli, Antonio Palla
Benefits and harms of long-term anticoagulant therapy (AT) after acute pulmonary embolism (PE) are poorly known. The aim of this study was to investigate the outcome of patients with PE treated with AT for 5 years according to American College of Chest Physicians (ACCP) guidelines.Patients with both unprovoked and secondary PE were consecutively enrolled in a "real life" study. After a 12-month AT, they continued or stopped the treatment according to ACCP guidelines, and were followed-up for 5 years. Outcomes were all-cause mortality, recurrence, and fatal recurrence under AT...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27553937/multicentre-external-validation-of-the-bimc-model-for-solid-solitary-pulmonary-nodule-malignancy-prediction
#16
Gian Alberto Soardi, Simone Perandini, Anna Rita Larici, Annemilia Del Ciello, Giovanna Rizzardi, Antonio Solazzo, Laura Mancino, Marco Bernhart, Massimiliano Motton, Stefania Montemezzi
OBJECTIVES: To provide multicentre external validation of the Bayesian Inference Malignancy Calculator (BIMC) model by assessing diagnostic accuracy in a cohort of solitary pulmonary nodules (SPNs) collected in a clinic-based setting. To assess model impact on SPN decision analysis and to compare findings with those obtained via the Mayo Clinic model. METHODS: Clinical and imaging data were retrospectively collected from 200 patients from three centres. Accuracy was assessed by means of receiver-operating characteristic (ROC) areas under the curve (AUCs)...
August 23, 2016: European Radiology
https://www.readbyqxmd.com/read/27525995/defining-futile-and-potentially-inappropriate-interventions-a-policy-statement-from-the-society-of-critical-care-medicine-ethics-committee
#17
Alexander A Kon, Eric K Shepard, Nneka O Sederstrom, Sandra M Swoboda, Mary Faith Marshall, Barbara Birriel, Fred Rincon
OBJECTIVES: The Society of Critical Care Medicine and four other major critical care organizations have endorsed a seven-step process to resolve disagreements about potentially inappropriate treatments. The multiorganization statement (entitled: An official ATS/AACN/ACCP/ESICM/SCCM Policy Statement: Responding to Requests for Potentially Inappropriate Treatments in Intensive Care Units) provides examples of potentially inappropriate treatments; however, no clear definition is provided...
September 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27521735/occupational-and-environmental-contributions-to-chronic-cough-in-adults-chest-expert-panel-report
#18
Susan M Tarlo, Kenneth W Altman, John Oppenheimer, Kaiser Lim, Anne Vertigan, David Prezant, Richard S Irwin
BACKGROUND: In response to occupational and environmental exposures, cough can be an isolated symptom reflecting exposure to an irritant with little physiological consequence, or it can be a manifestation of more significant disease. This document reviews occupational and environmental contributions to chronic cough in adults, focusing on aspects not previously covered in the 2006 ACCP Cough Guideline or our more recent systematic review, and suggests an approach to investigation of these factors when suspected...
October 2016: Chest
https://www.readbyqxmd.com/read/27518175/evaluation-outcomes-associated-with-alternative-dosing-strategies-for-piperacillin-tazobactam-a-systematic-review-and-meta-analysis
#19
Hui Yang, Xiangli Cui, Zhuo Ma, Lihong Liu
A better dosing strategy can improve clinical outcomes for patients. We systematically reviewed the literatures to determine whether any clinical benefits exist for piperacillin/tazobactam by extended or continuous infusion. Methods - A search of PubMed, Web of Science, ProQuest, ScienceDirect, Cochrane, Embase and related ICAAC and ACCP conferences were conducted up to September 5, 2015. Randomized controlled and observational studies that compared extended or continuous infusion with conventional intermittent infusion of piperacillin/tazobactam were identified from the databases above and analyzed...
April 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27516802/a-novel-point-for-warfarin-usage-in-accp-guidelines-2012-and-its-importance-for-quality-of-anticoagulation-commentary-on-the-article-by-dr-ciurus-et-al-kardiochir-torakochir-pol-2015-12-4-334-340
#20
Fahri Gurkan Yesil, Mustafa Kurkluoglu, Adem Guler, Mehmet Ali Sahin, Bilgehan Savas Oz
No abstract text is available yet for this article.
June 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
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