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Advances in heart failure

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https://www.readbyqxmd.com/read/29148148/an-integrative-translational-approach-to-study-heart-failure-with-preserved-ejection-fraction-a-position-paper-from-the-working-group-on-myocardial-function-of-the-european-society-of-cardiology
#1
REVIEW
Andre P Lourenço, Adelino F Leite-Moreira, Jean-Luc Balligand, Johann Bauersachs, Dana Dawson, Rudolf A de Boer, Leon J de Windt, Inês Falcão-Pires, Ricardo Fontes-Carvalho, Stefan Franz, Mauro Giacca, Denise Hilfiker-Kleiner, Emilio Hirsch, Christoph Maack, Manuel Mayr, Burkert Pieske, Thomas Thum, Carlo G Tocchetti, Dirk L Brutsaert, Stephane Heymans
As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages...
November 16, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29147800/the-pediatric-heart-failure-workforce-an-international-multicenter-survey
#2
Scott R Auerbach, Melanie D Everitt, Ryan J Butts, David N Rosenthal, Yuk M Law
Our objective was to understand the scope of pediatric heart failure (HF) and the current staffing environment of HF programs. An online survey was distributed to members of the Pediatric Heart Transplant Study and the Pediatric Council of the International Society for Heart and Lung Transplantation. All participants received the primary 23-question survey. Additionally, HF program directors received a 32-question supplemental survey. Of 235 invitations sent, there were 69 (29%) primary surveys and 34 program director surveys completed (24 U...
November 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29147074/increased-levels-of-srage-in-diabetic-ckd-g5d-patients-a-potential-protective-mechanism-against-age-related-upregulation-of-fibroblast-growth-factor-23-and-inflammation
#3
Elena Dozio, Valentina Corradi, Elena Vianello, Elisa Scalzotto, Massimo de Cal, Massimiliano Marco Corsi Romanelli, Claudio Ronco
Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29142816/unilateral-pulmonary-edema-in-a-patient-with-worsening-tricuspid-valve-regurgitation-a-secret-inside-pulmonary-veins
#4
Elvira Resciniti, Ilaria Caso, Iside Scarfò, Giuseppe Di Pasquale, Giovanni La Canna
We present the case of a 69-year-old patient who was referred to the Department of Echocardiography for surgical treatment of severe tricuspid valve regurgitation (TVR) with advanced congestive heart failure. In 2013 the patient underwent unsuccessful percutaneous ablation for permanent atrial fibrillation. In 2015, following numerous episodes of atrial fibrillation and congestive heart failure with left pleural effusion, the patient was admitted to another center. A transthoracic echocardiogram showed severe TVR and moderate precapillary pulmonary hypertension, confirmed at right cardiac catheterization...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29138179/association-between-leukocyte-telomere-length-and-the-risk-of-incident-atrial-fibrillation-the-framingham-heart-study
#5
Laila Staerk, Biqi Wang, Kathryn L Lunetta, Robert H Helm, Darae Ko, Jason A Sherer, Patrick T Ellinor, Steven A Lubitz, David D McManus, Ramachandran S Vasan, Emelia J Benjamin, Ludovic Trinquart
BACKGROUND: Advancing age is a prominent risk factor for atrial fibrillation (AF). Shorter telomere length is a biomarker of biological aging, but the link between shorter telomere length and increased risk of AF remains unclear. We examined the association between shorter leukocyte telomere length (LTL) and incident AF. METHODS AND RESULTS: We included AF-free participants from the observational Framingham Heart Study Offspring cohort from 1995 to 1998, who had LTL measurements...
November 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29135524/a-palliative-approach-for-heart-failure-end-of-life-care
#6
Jane Maciver, Heather J Ross
PURPOSE OF REVIEW: The current review discusses the integration of guideline and evidence-based palliative care into heart failure end-of-life (EOL) care. RECENT FINDINGS: North American and European heart failure societies recommend the integration of palliative care into heart failure programs. Advance care planning, shared decision-making, routine measurement of symptoms and quality of life and specialist palliative care at heart failure EOL are identified as key components to an effective heart failure palliative care program...
November 10, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29132918/the-first-in-human-experience-with-a-minimally-invasive-ambulatory-counterpulsation-heart-assist-system-for-advanced-congestive-heart-failure
#7
Valluvan Jeevanandam, Tae Song, David Onsager, Takeyoshi Ota, Colleen Juricek LaBuhn, Thomas Lammy, Gabriel Sayer, Gene Kim, Sonna Patel-Raman, Nir Uriel
BACKGROUND: The intravascular ventricular assist system (iVAS) is a new, minimally invasive, ambulatory counterpulsation heart assist system delivered via the subclavian artery and powered by a portable driver. It is designed for recovery, bridge to transplantation (BTT) or for prolonging medical therapy. We report the first-in-human (FIH) experience with iVAS. METHODS: This is a prospective, non-randomized single arm, U.S. Food and Drug Administration (FDA)-approved early feasibility trial in patients listed for cardiac transplantation...
November 10, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29132217/update-on-pulmonary-arterial-hypertension-research-proceedings-from-a-meeting-of-experts
#8
Vallerie McLaughlin, Matthew Bacchetta, David Badesch, Raymond Benza, Charles Burger, Kelly Chin, Robert Frantz, Adaani Frost, Anna Hemnes, Nick H Kim, Erika B Rosenzweig, Lewis Rubin
While pulmonary arterial hypertension (PAH) remains a progressive, symptomatic condition characterized by increased pulmonary vascular resistance, ultimately leading to right heart failure, great strides have been made in its understanding and treatment over the past two decades. Continued research in preclinical, clinical, and health economic areas of research, in addition to registry analyses and technology advances, is critical for understanding the pathophysiology of the disease and devising the best ways to monitor and manage patients...
November 13, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29130535/between-center-disparities-in-access-to-heart-transplantation-in-france-contribution-of-candidate-and-center-factors
#9
Christelle Cantrelle, Richard Dorent, Emilie Savoye, Philippe Tuppin, Guillaume Lebreton, Camille Legeai, Olivier Bastien
Transplantation represents the last option for patients with advanced heart failure. We assessed between-center disparities in access to heart transplantation in France one year after registration and evaluated the contribution of factors to these disparities. Adults (n=2,347) registered on the French national waiting list between January 1, 2010 and December 31, 2014 in the 23 transplant centers were included. Associations between candidate and transplant center characteristics and access to transplantation were assessed by proportional hazards frailty models...
November 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29129497/frailty-and-clinical-outcomes-in-advanced-heart-failure-patients-undergoing-left-ventricular-assist-device-implantation-a-systematic-review-and-meta-analysis
#10
Gary Tse, Mengqi Gong, Sunny Hei Wong, William K K Wu, George Bazoukis, Konstantinos Lampropoulos, Wing Tak Wong, Yunlong Xia, Martin C S Wong, Tong Liu, Jean Woo
BACKGROUND: Frailty has been identified as a risk factor for adverse clinical outcomes after cardiac intervention or surgery. However, whether it increases the risk of adverse outcomes in patients undergoing left ventricular assist device (LVAD) therapy has been controversial. Therefore, we conducted a systematic review and meta-analysis of the frailty measures and clinical outcomes of length of stay and mortality in this setting. METHODS: PubMed and Embase were searched until September 11, 2017, for studies evaluating the association between frailty and clinical outcomes in advanced heart failure patients undergoing LVAD implantation...
November 9, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29128777/a-systematic-review-of-heart-failure-dyadic-self-care-interventions-focusing-on-intervention-components-contexts-and-outcomes
#11
REVIEW
Harleah G Buck, Anna Stromberg, Misook L Chung, Kristine A Donovan, Karen Harkness, Allison M Howard, Naoko Kato, Randall Polo, Lorraine S Evangelista
BACKGROUND: Having support from an informal carer is important for heart failure patients. Carers have the potential to improve patient self-care. At the same time, it should be acknowledged that caregiving could affect the carer negatively and cause emotional reactions of burden and stress. Dyadic (patient and informal carer) heart failure self-care interventions seek to improve patient self-care such as adherence to medical treatment, exercise training, symptom monitoring and symptom management when needed...
October 19, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29127185/advances-in-computational-modelling-for-personalised-medicine-after-myocardial-infarction
#12
REVIEW
Kenneth Mangion, Hao Gao, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide. Determining which patients will experience heart failure and sudden cardiac death after an acute MI is notoriously difficult for clinicians. The extent of heart damage after an acute MI is informed by cardiac imaging, typically using echocardiography or sometimes, cardiac magnetic resonance (CMR). These scans provide complex data sets that are only partially exploited by clinicians in daily practice, implying potential for improved risk assessment...
November 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29125137/red-blood-cell-distribution-width-relative-lymphocyte-count-and-type-2-diabetes-mellitus-predict-all-cause-mortality-in-patients-with-advanced-heart-failure
#13
Bożena Szyguła-Jurkiewicz, Łukasz Siedlecki, Łukasz Pyka, Ewa Romuk, Piotr Przybyłowski, Mariusz Gąsior
INTRODUCTION    Early identification of patients with advanced heart failure (HF) who are at a higher risk for poor outcome is an important element of patient management, both from the medical and the economic point of view. OBJECTIVES    In the present study, we sought to determine the association between hematologic parameters assessed on admission and within the 3-year mortality period in patients consecutively admitted with advanced HF.  We also investigated the association between baseline demographic and clinical data and mortality...
November 9, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29124464/linezolid-associated-hypoglycemia
#14
Herman Joseph Johannesmeyer, Suhani Bhakta, Felix Morales
Our case describes a 77-year-old, African American male who was experiencing recurrent hypoglycemic episodes, which resulted in two emergency department (ED) visits and a subsequent inpatient admission during his second ED visit. He was prescribed linezolid 600 mg twice daily for 14 days for the treatment of a Staphylococcus hominis urinary tract infection. Nine and a half days into therapy, the patient began having recurrent hypoglycemic episodes. These episodes persisted despite repeated intravenous dextrose boluses...
November 9, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29119374/review-of-cardiovascular-imaging-in-the-journal-of-nuclear-cardiology-2017-part-1-of-2-positron-emission-tomography-computed-tomography-and-magnetic-resonance
#15
Wael A AlJaroudi, Fadi G Hage
Several original articles and editorials have been published in the Journal of Nuclear Cardiology in 2017. It has become a tradition at the beginning of each year to summarize some of these key articles in 2 sister reviews. In this first part one, we will discuss some of the progress made in the field of heart failure (cardio-oncology, myocardial blood flow, viability, dyssynchrony, and risk stratification), inflammation, molecular and hybrid imaging using advancement in positron emission tomography, computed tomography, and magnetic resonance imaging...
November 8, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29118467/the-light-and-shadow-of-senescence-and-inflammation-in-cardiovascular-pathology-and-regenerative-medicine
#16
REVIEW
Laura Iop, Eleonora Dal Sasso, Leonardo Schirone, Maurizio Forte, Mariangela Peruzzi, Elena Cavarretta, Silvia Palmerio, Gino Gerosa, Sebastiano Sciarretta, Giacomo Frati
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised tissue abilities to protect the heart against stress. At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29117575/self-assembling-peptide-hydrogel-enables-instant-epicardial-coating-of-the-heart-with-mesenchymal-stromal-cells-for-the-treatment-of-heart-failure
#17
Yuki Ichihara, Masahiro Kaneko, Kenichi Yamahara, Marinos Koulouroudias, Nobuhiko Sato, Rakesh Uppal, Kenji Yamazaki, Satoshi Saito, Ken Suzuki
Transplantation of mesenchymal stromal cells (MSCs) is an emerging therapy for the treatment of heart failure. However, the delivery method of MSC is currently suboptimal. The use of self-assembling peptide hydrogels, including PuraMatrix(®) (PM; 3-D Matrix, Ltd), has been reported for clinical hemostasis and in research models. This study demonstrates the feasibility and efficacy of an advanced approach for MSC-therapy, that is coating of the epicardium with the instantly-produced PM hydrogel incorporating MSCs (epicardial PM-MSC therapy)...
October 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/29114921/association-of-early-left-ventricular-dysfunction-with-advanced-magnetic-resonance-white-matter-and-gray-matter-brain-measures-the-cardia-study
#18
Anderson C Armstrong, Majon Muller, Bharath Ambale-Ventakesh, Michael Halstead, Satoru Kishi, Nick Bryan, Stephen Sidney, Luís C L Correia, Samuel S Gidding, Lenore J Launer, João A C Lima
INTRODUCTION: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. AIMS: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. METHODS: The CARDIA study enrolled 5115 young adults aged 18-30 years at baseline (1985-1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010-2011)...
November 8, 2017: Echocardiography
https://www.readbyqxmd.com/read/29114596/clinical-outcomes-of-intensity-modulated-proton-therapy-and-concurrent-chemotherapy-in-esophageal-carcinoma-a-single-institutional-experience
#19
Anussara Prayongrat, Cai Xu, Heng Li, Steven H Lin
Purpose: Intensity-modulated proton therapy (IMPT) is an emerging advanced radiation technique. Although dosimetric studies demonstrate the superiority of IMPT for improving target conformity and reducing unnecessary dose to critical normal tissues, clinical experience is limited. We aim to describe our preliminary experience implementing IMPT concurrently with chemotherapy in esophageal carcinoma (EC). Methods and materials: From May 2011 through February 2016, 19 patients with EC (median age, 73 years) were treated with IMPT using 180 to 250 MV protons with a median dose of 50...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29113705/recent-advances-in-diagnosis-and-treatment-of-cardiac-amyloidosis
#20
REVIEW
Yasuhiro Izumiya, Seiji Takashio, Seitaro Oda, Yasuyuki Yamashita, Kenichi Tsujita
Cardiac amyloidosis (CA) has been believed to be a rare disease for a long time, but recent sophisticated diagnostic modalities demonstrate that a considerable number of CA patients are hidden among those diagnosed with heart failure. Prognosis of CA was poor, but recent developments in therapeutic interventions have improved survival in these patients. Therefore, early detection and precise diagnosis is clinically important. In this review article, we overview recent progress in diagnosis and treatment for CA...
November 4, 2017: Journal of Cardiology
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