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https://www.readbyqxmd.com/read/29242654/comparison-of-volume-control-and-pressure-control-ventilation-in-patients-undergoing-single-level-anterior-cervical-discectomy-and-fusion-surgery
#1
Srilata Moningi, Praveen Kumar Elmati, Prasad Rao, Geetha Kanithi, Dilip Kumar Kulkarni, Gopinath Ramachandran
Background and Aims: Pressure control and volume control ventilation are the most preferred modes of ventilator techniques available in the intraoperative period. The study compared the intraoperative ventilator and blood gas variables of volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) in patients undergoing single level anterior cervical discectomy and fusion (ACDF). Methods: After obtaining Institutional Ethical Committee approval and informed consent, sixty patients scheduled for single level ACDF surgery performed in supine position under general anaesthesia were included...
October 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29242653/awake-orotracheal-fibre-optic-intubation-comparison-of-two-different-doses-of-dexmedetomidine-on-intubation-conditions-in-patients-undergoing-cervical-spine-surgery
#2
Jaya Sharma, Shobha Purohit, Sonali Bhatia, Poonam Kalra, Mamta Sharma, Reema Meena
Background and Aims: Awake fibre-optic intubation (AFOI) is an integral part of anaesthetic management of difficult airways. Conscious sedation is essential to assist AFOI. This study compared two different doses of dexmedetomidine in combination with topical spray and airway blocks for awake orotracheal fibre-optic intubation in patients undergoing elective cervical spine surgery with rigid cervical collar in situ. Methods: A randomized, prospective, comparative study design was conducted in sixty patients divided into two groups: Group (L) (n = 30) patients received low dose of dexmedetomidine (0...
October 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29242264/prognostic-value-of-right-ventricular-dilatation-in-patients-with-low-risk-pulmonary-embolism
#3
Benoit Côté, David Jiménez, Benjamin Planquette, Anne Roche, Jonathan Marey, Jean Pastré, Guy Meyer, Olivier Sanchez
The prognosis of multidetector computed tomography (MDCT) assessed right ventricular dilatation (RVD) is unclear in patients with pulmonary embolism (PE) and a simplified Pulmonary Embolism Severity Index (sPESI) of 0. We investigated in these patients whether MDCT-assessed RVD, defined by a right to left ventricular ratio (RV/LV) ≥0.9 or ≥1.0, is associated with worse outcomes.We combined data from three prospective cohorts of patients with PE. The main study outcome was the composite of 30-day all-cause mortality, haemodynamic collapse or recurrent PE in patients with sPESI of 0...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29241463/-myocardial-contusion-following-trauma
#4
R T Stolmeijer, H Lameijer
BACKGROUND: Myocardial contusion is a potentially life threatening condition, which should be considered in patients with a compatible thoracic trauma. Guidelines for diagnosis and determination of management are non-existent. CASE DESCRIPTION: A 51-year-old man arrived at the accident and emergency department with thoracic trauma after being knocked down by a bus. A myocardial contusion was diagnosed based on the ECG and elevated high-sensitivity (hs) troponin levels...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29240905/coronary-autoregulation-and-assessment-of-stenosis-severity-without-pharmacological-vasodilation
#5
Guus A de Waard, Christopher M Cook, Niels van Royen, Justin E Davies
For identification of myocardial ischaemia by non-invasive imaging or invasive physiological assessment, administration of a vasodilating or positive inotropic agent is often considered indispensable to exhaust the cardiac compensation mechanisms. Indeed, microcirculatory dilatation is needed for assessment of myocardial perfusion or coronary blood flow. However, three different modalities exist that quantify myocardial ischaemia without recourse to pharmacological stress agents, using either myocardial contrast echocardiography, imaging of myocardial blood volume or invasive coronary pressure measurement with the instantaneous wave-free ratio (iFR)...
December 11, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29240070/-method-of-forming-a-distal-anastomosis-with-an-autovenous-cuff
#6
A G Shalashov
Presented herein is a brief review of the world literature dedicated to methods of formation of composite arterial anastomoses in the femoropopliteal-tibial region The most justified is considered the use of a composite shunt formed proximally from a synthetic vascular graft made of polytetrafluoroethylene and distally with an extension from a portion of the suitable for reconstruction autovein (the so-called autovenous cuff of patch). The use of an autovenous cuff is more physiological since it provides closer correspondence of the diameters of the distal anastomosis being applied between the artery and autovenous extension, as well as contributes to creation of more adequate haemodynamic conditions in the shunt...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29240066/peculiarities-of-vitalization-of-grafts-made-of-porous-polytetrafluoroethylene-in-reconstruction-of-major-veins-an-experimental-study
#7
S É Voskanian, M V Shabalin, A V Volkov, I Iu Kolyshev
Increased incidence of locally disseminated malignant neoplasms with invasion of major veins compels modern surgery to search for an optimal material for reconstruction of major veins. Presented herein are the results of an experimental study aimed at exploring patency and peculiarities of vitalization of grafts made of porous polytetrafluoroethylene (7th generation, 2010) manufactured by the Closed Joint Stock Company 'Research and Production Complex 'Ecoflon' (St. Petersburg, Russia) with an internal diameter measuring 4...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29240063/-simultaneous-operation-in-a-patient-with-stenosis-of-the-extracranial-portion-and-an-intracranial-aneurysm-of-the-internal-carotid-artery
#8
A N Kazantsev, R S Tarasov, A I Anufriev, N N Burkov, A R Shabaev, E V Ruban
Presented herein is a clinical case report concerning surgical treatment of a patient with a rare combination of two pathologies, i. e., a haemodynamically significant stenosis of the extracranial portion and a sacciform aneurysm of the communicative portion of the right internal carotid artery on the background of multifocal atherosclerosis. The patient underwent a simultaneous operation consisting in clipping of the sacciform arterial aneurysm of the communicative portion of the right internal carotid artery and carotid endarterectomy on the right...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29240056/-hybrid-intervention-for-a-multilevel-aneurysmatic-lesion-of-the-aorta-in-a-patient-with-multifocal-atherosclerosis
#9
K V Kochkina, A V Sidorenko, A V Myznikov, G A Usik, A A Shtark, T A Kochkina, A V Pustovoĭtov, A V Protopopov
A multilevel aneurysmatic lesion of the aorta is a rare pathology. The authors describe herein a clinical case report regarding stage-wise treatment of a patient presenting with aneurysms of the thoracic and abdominal portions of the aorta and a haemodynamically significant lesion of coronary and carotid arteries. Strategy of surgical management was decided upon collegially. Successful endoprosthetic repair of the aneurysm of the thoracic portion of the aorta required closure of the left carotid artery with a graft, which, taking into consideration an existing occlusion of the right internal carotid artery, demanded preliminary carotid-subclavian bypass grafting...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29240049/-use-of-local-thrombolysis-in-patients-with-massive-pulmonary-thromboembolism-and-moderate-to-severe-pulmonary-hypertension
#10
Iu E Klevanets, A A Karpenko, A N Shilova
Presented herein are the results of treating a total of 110 patients with acute massive pulmonary thromboembolism. The patients included in the study were divided into 2 groups depending on the degree of severity of pulmonary hypertension. All patients underwent interventional treatment, i.e., endovascular mechanical fragmentation with local thrombolysis. Both short- and long-term outcomes were then analysed. Performing local thrombolysis made it possible to achieve regression of clinical manifestations of acute respiratory insufficiency in more than 98% of patients...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29239515/rationale-and-design-of-transition-a-randomized-trial-of-pre-discharge-vs-post-discharge-initiation-of-sacubitril-valsartan
#11
Domingo Pascual-Figal, Rolf Wachter, Michele Senni, Jan Belohlavek, Adele Noè, David Carr, Dmytro Butylin
AIMS: The prognosis after hospitalization for acute decompensated heart failure (ADHF) remains poor, especially <30 days post-discharge. Evidence-based medications with prognostic impact administered at discharge improve survival and hospital readmission, but robust studies comparing pre-discharge with post-discharge initiation are rare. The PARADIGM-HF trial established sacubitril/valsartan as a new evidence-based therapy in patients with heart failure (HF) and reduced left ventricular ejection fraction (<40%) (rEF)...
December 14, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29238586/international-prospective-observational-study-of-upper-gastrointestinal-haemorrhage-does-weekend-admission-affect-outcome
#12
Iain A Murray, Harry R Dalton, Adrian J Stanley, Jing H Ngu, Brian Maybin, Mahmoud Eid, Kenneth G Madsen, Rozeta Abazi, Hamad Ashraf, Mohamed Abdelrahim, Rebecca Lissmann, Jenny Herrod, Christopher Jl Khor, Hock S Ong, Doreen Sc Koay, Yung K Chin, Stig B Laursen
Introduction: Out of hours admissions have higher mortality for many conditions but upper gastrointestinal haemorrhage studies have produced variable outcomes. Methods: Prospective study of 12 months consecutive admissions of upper gastrointestinal haemorrhage from four international high volume centres. Admission period (weekdays, weeknights or weekends), demographics, haemodynamic parameters, laboratory results, endoscopy findings, further procedures and 30-day mortality were recorded...
December 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29237825/mitochondrial-ca2-transport-in-the-endothelium-regulation-by-ions-redox-signalling-and-mechanical-forces
#13
REVIEW
B Rita Alevriadou, Santhanam Shanmughapriya, Akshar Patel, Peter B Stathopulos, Muniswamy Madesh
Calcium (Ca2+) transport by mitochondria is an important component of the cell Ca2+ homeostasis machinery in metazoans. Ca2+ uptake by mitochondria is a major determinant of bioenergetics and cell fate. Mitochondrial Ca2+ uptake occurs via the mitochondrial Ca2+ uniporter (MCU) complex, an inner mitochondrial membrane protein assembly consisting of the MCU Ca2+ channel, as its core component, and the MCU complex regulatory/auxiliary proteins. In this review, we summarize the current knowledge on the molecular nature of the MCU complex and its regulation by intra- and extramitochondrial levels of divalent ions and reactive oxygen species (ROS)...
December 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29237015/perceval-less-invasive-aortic-replacement-register-multicentric-spanish-experience-with-the-perceval-s-bioprosthesis-in-moderate-high-risk-aortic-surgery
#14
Elisabet Berastegui García, Maria Luisa Camara Rosell, Francisco Estevez Cid, Eladio Sanchez Dominguez, Remedios Rios Barrera, Fabrizio Sbraga, Julio Garcia Puente, Elena Rosello Diez, Gregorio Pablo Cuerpo Caballero, Juan Bustamante Munguira, Guillermo Reyes Copa, Marian Tena Pajuelo, Santiago Serrano Fiz, Jose Alfonso Buendía Miñano, Ivan García Martin, Jose Cuenca Castillo, Sergio Cánovas Lopez, Angel Gonzalez Pinto, Xavier Ruyra Baliarda
OBJECTIVES: The development of new percutaneous and surgical techniques has reduced the risk associated with aortic valve replacement procedures. We present the results of a Spanish register after initiating a programme for sutureless prostheses in moderate-high-risk patients. METHODS: This prospective multicentre study was carried out from November 2013 to November 2016. Data were obtained from 448 patients in whom a Perceval S prosthesis was implanted. RESULTS: The mean age was 79...
December 8, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29236952/impaired-cardiac-contractile-function-in-agat-knockout-mice-devoid-of-creatine-is-rescued-by-homoarginine-but-not-creatine
#15
Kiterie M E Faller, Dorothee Atzler, Debra J McAndrew, Sevasti Zervou, Hannah J Whittington, Jillian N Simon, Dunja Aksentijevic, Michiel Ten Hove, Chi-Un Choe, Dirk Isbrandt, Barbara Casadei, Jurgen E Schneider, Stefan Neubauer, Craig A Lygate
Aims: Creatine buffers cellular ATP via the creatine kinase reaction. Creatine levels are reduced in heart failure, but their contribution to pathophysiology is unclear. Arginine:glycine amidinotransferase (AGAT) in the kidney catalyses both the first step in creatine biosynthesis as well as homoarginine synthesis. AGAT-/- mice fed a creatine-free diet have a whole body creatine-deficiency. We hypothesised that AGAT-/- mice would develop cardiac dysfunction and rescue by dietary creatine would imply causality...
December 11, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29233756/paediatric-minimally-invasive-abdominal-and-urological-surgeries-current-trends-and-perioperative-management
#16
Myriam Bellon, Alia Skhiri, Florence Julien-Marsollier, Serge Malbezin, Diallo Thierno, Julie Hilly, Alaa ElGhoneimi, Arnaud Bonnard, Daphné Michelet, Souhayl Dahmani
Minimally invasive surgery during abdominal, thoracic and urological procedures has become the standard management of many surgical interventions in adults. Recent development of smaller devices has allowed the management of many paediatric surgeries using these minimally invasive techniques. However, the lack of knowledge of (a) adequate management of haemodynamic and respiratory alterations occurring during those procedures and (b) postoperative advantages of these techniques over open surgeries, still impairs their development...
December 9, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29228054/brain-to-brain-hyperclassification-reveals-action-specific-motor-mapping-of-observed-actions-in-humans
#17
Dmitry Smirnov, Fanny Lachat, Tomi Peltola, Juha M Lahnakoski, Olli-Pekka Koistinen, Enrico Glerean, Aki Vehtari, Riitta Hari, Mikko Sams, Lauri Nummenmaa
Seeing an action may activate the corresponding action motor code in the observer. It remains unresolved whether seeing and performing an action activates similar action-specific motor codes in the observer and the actor. We used novel hyperclassification approach to reveal shared brain activation signatures of action execution and observation in interacting human subjects. In the first experiment, two "actors" performed four types of hand actions while their haemodynamic brain activations were measured with 3-T functional magnetic resonance imaging (fMRI)...
2017: PloS One
https://www.readbyqxmd.com/read/29227869/reliability-of-oscillometric-central-blood-pressure-responses-to-lower-limb-resistance-exercise
#18
Simon Fryer, Keeron Stone, Tabitha Dickson, James Faulkner, Danielle Lambrick, Pablo Corres, Lauren Jerred, Lee Stoner
BACKGROUND AND AIMS: Although it is well known that resistance training (RT) is beneficial for patients suffering from a variety of cardiovascular diseases, it remains underutilized as a rehabilitation tool as there is no reliable way to monitor the additional stress placed on the central organs. The current study aimed to determine between-day reliability of central haemodynamic indices using oscillometric pulse wave analysis (PWA) during progressive sub-maximal RT. METHODS: Nineteen healthy young males were tested on 3 different mornings in a fasted state...
December 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29224239/personalized-stepwise-vascular-control-during-complex-hepatectomy-involving-hepatocaval-confluence
#19
Lei Dou, Zong-Ping Yu, Hui-Yuan Yang, Ji Ran, Yi-Fa Chen, Xiao-Ping Chen
BACKGROUND: This study introduces an innovative stepwise vascular control technique to address the high risk of massive bleeding from main hepatic veins and the retro-hepatic inferior vena cava during hepatectomy involving hepatocaval confluence. METHODS: From January 2010 to July 2016, 80 patients underwent stepwise vascular occlusion during complex liver resection involving hepatocaval confluence. Relevant clinical data were collected and compared with those obtained in parallel studies...
December 10, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29223567/predictive-ability-of-the-evaruci-scale-and-comhon-index-for-pressure-injury-risk-in-critically-ill-patients-a-diagnostic-accuracy-study
#20
M de Los Ángeles Leal-Felipe, M Del Carmen Arroyo-López, M Del Cristo Robayna-Delgado, Ana Gómez-Espejo, Patricia Perera-Díaz, Carmen D Chinea-Rodríguez, Natalia García-Correa, Alejandro Jiménez-Sosa
BACKGROUND: Hospital-acquired pressure injuries are a costly and largely preventable complication occurring in a variety of acute care settings. Patients admitted to the intensive care unit are at greater risk of developing pressure injuries. OBJECTIVE: To determine whether the efficiency of scales to measure pressure injury risk increase when a continuously updated 3-day moving average method is used. METHODS: With a retrospective cohort design we recruited 3085 patients treated between June 2011 and February 2015 in the intensive care unit of a tertiary level university hospital...
December 6, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
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