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https://www.readbyqxmd.com/read/28092845/cinnamaldehyde-potentially-attenuates-gestational-hyperglycemia-in-rats-through-modulation-of-ppar%C3%AE-proinflammatory-cytokines-and-oxidative-stress
#1
Ahmed A Hosni, A Adel Abdel-Moneim, Eman S Abdel-Reheim, Samah M Mohamed, Hamdi Helmy
Cinnamon has a history of use for medicinal purposes and its major benefits have been linked to cinnamaldehyde. The present study aimed to investigate the hypoglycemic action of cinnamaldehyde against fatty-sucrosed diet/streptozotocin (FSD/STZ)-rat model of gestational diabetes. Female albino rats were divided into three groups. Group I fed with normal diet (ND) while group II and III were fed with FSD for eight weeks (five weeks pre-gestational and three weeks gestational). Rats of group III were administered with a daily oral dose of 20mg/kg cinnamaldehyde one week before mating onward...
January 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28092062/-it-s-a-very-big-burden-on-me-women-s-experiences-using-insulin-for-gestational-diabetes
#2
Marlaine Figueroa Gray, Clarissa Hsu, Linda Kiel, Sascha Dublin
Objectives Gestational Diabetes Mellitus (GDM) affects hundreds of thousands of women each year. Many require medications to manage their blood glucose levels. Only insulin is approved by the U.S. Food and Drug Administration for use in pregnancy. While other medications can be used, their safety remains controversial. Few studies have examined women's lived experience of using insulin for GDM. Our objective in this study was to foreground the voices of women speaking about their treatment experience. Methods We conducted two focus groups including 16 women treated for GDM with medications, primarily insulin...
January 13, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28091647/phytosterol-nutritional-supplement-improves-pregnancy-and-neonatal-complications-of-gestational-diabetes-mellitus-in-a-double-blind-and-placebo-controlled-clinical-study
#3
Fang Gao, Guangya Wang, Linxia Wang, Ningning Guo
Gestational diabetes mellitus (GDM) is an increasingly serious health problem among pregnant women. Phytosterol-enriched spreads are known to reduce total cholesterol (TC) and low-density lipoprotein (LDL), but little is known about their effects on GDM. We aimed to examine the effect of the daily consumption of phytosterol-enriched spreads on both the maternal and neonatal outcomes of GDM patients. GDM patients during the third trimester of pregnancy were enrolled and assigned randomly to consume a regular spread or phytosterol-enriched spread daily until the end of their pregnancy...
January 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28090333/urinary-c-peptide-creatinine-ratio-in-pregnant-women-with-normal-glucose-tolerance-and-type-1-diabetes-evidence-for-insulin-secretion
#4
Ankica Markoska, Rajalakshmi Valaiyapathi, Chloe Thorn, Anne Dornhorst
HYPOTHESIS: In pregnancy, urinary C peptide creatinine ratio (UCPCR) reflects endogenous insulin secretion in women with normal glucose tolerance and type 1 diabetes. RESEARCH DESIGN AND METHODS: UCPCR and serum C peptide were measured in 90 glucose-tolerant women at 0 and 120 min during a 75 g oral glucose tolerance test (OGTT) at 28 weeks of gestation. UCPCR was measured in 2 samples obtained over 10 weeks apart in 7 pregnant women with longstanding type 1 diabetes...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28080219/adipose-tissue-insulin-resistance-in-gestational-diabetes
#5
Batbayar Tumurbaatar, Aaron T Poole, Gayle Olson, Michel Makhlouf, Hanaa S Sallam, Shwetha Thukuntla, Sucharitha Kankanala, Obos Ekhaese, Guillermo Gomez, Manisha Chandalia, Nicola Abate
BACKGROUND: Gestational diabetes mellitus (GDM) is a metabolic disorder characterized by insulin resistance (IR) and altered glucose-lipid metabolism. We propose that ectonucleotide pyrophosphate phosphodiesterase-1 (ENPP1), a protein known to induce adipocyte IR, is a determinant of GDM. Our objective was to study ENPP1 expression in adipose tissue (AT) of obese pregnant women with or without GDM, as well as glucose tolerance in pregnant transgenic (Tg) mice with AT-specific overexpression of human ENPP1...
January 12, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28078553/expression-of-apoptosis-regulatory-genes-in-the-hippocampus-of-rat-neonates-born-to-mothers-with-diabetes
#6
Hossein Haghir, Javad Hami, Nassim Lotfi, Mostafa Peyvandi, Simagol Ghasemi, Mehran Hosseini
Diabetes during pregnancy impairs the development of the central nervous system (CNS) and causes cognitive and behavioral abnormalities in offspring. However, the exact mechanism by which the maternal diabetes affects the development of the brain remains to be elucidated. The aim of the present study was to investigate the effects of maternal diabetes in pregnancy on the expression of Bcl-2 and Bax genes and the numerical density of degenerating dark neurons (DNs) in the hippocampus of offspring at the first postnatal two weeks...
January 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28077460/glyburide-versus-metformin-and-their-combination-for-the-treatment-of-gestational-diabetes-mellitus-a-randomized-controlled-study
#7
Zohar Nachum, Noah Zafran, Raed Salim, Noura Hissin, Jamal Hasanein, Yifat Gam Ze Letova, Abeer Suleiman, Enav Yefet
OBJECTIVE: To compare the efficacy and safety of glyburide versus metformin and their combination for the treatment of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: In this prospective randomized controlled study, we randomly assigned patients with GDM at 13-33 weeks gestation and whose blood glucose was poorly controlled by diet to receive either glyburide or metformin. If optimal glycemic control was not achieved, the other drug was added. If adverse effects occurred, the drug was replaced...
January 11, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28074994/-normoglycemic-diabetic-ketoacidosis-in-pregnancy-report-of-one-case
#8
Margarita Rivas M, Pamela Belmar Z, Pilar Durruty A, Lilian Sanhueza M, Gloria López S
Normoglycemic diabetic ketoacidosis should be suspected in pregnant women presenting nausea, vomiting, abdominal pain and anorexia. We report a 39 years old woman with a 32 weeks pregnancy who sought emergency care due to hyperemesis. She was hospitalized with the following diagnoses: pregnancy hypertension syndrome, gestational diabetes, morbid obesity and poor prenatal control. The evaluation of the feto-placental unit showed perception of fetal movements, non-reactive non-stress baseline record and a biophysical profile of 6/8...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28073830/adiponectin-deficiency-impairs-maternal-metabolic-adaptation-to-pregnancy-in-mice
#9
Liping Qiao, Jean-Sebastien Wattez, Samuel Lee, Amanda Nguyen, Jerome Schaack, William W Hay, Jianhua Shao
Hypoadiponectinemia has been widely observed in patients with gestational diabetes. To investigate the causal role of hypoadiponectinemia in gestational diabetes, adiponectin gene knockout (Adipoq(-/-)) and wild-type (WT) mice were crossed to produce pregnant mouse models with or without adiponectin deficiency. Adenoviral vector-mediated in vivo transduction was used to reconstitute adiponectin during late pregnancy. Results showed that Adipoq(-/-) dams developed glucose intolerance and hyperlipidemia in late pregnancy...
January 10, 2017: Diabetes
https://www.readbyqxmd.com/read/28050707/effect-of-parental-obesity-and-gestational-diabetes-on-child-neuropsychological-and-behavioral-development-at-4%C3%A2-years-of-age-the-rhea-mother-child-cohort-crete-greece
#10
Vasiliki Daraki, Theano Roumeliotaki, Katerina Koutra, Vaggelis Georgiou, Mariza Kampouri, Andriani Kyriklaki, Marina Vafeiadi, Stathis Papavasiliou, Manolis Kogevinas, Leda Chatzi
Studies have suggested an association between maternal obesity pre-pregnancy and gestational diabetes (GDM) with impaired offspring neurodevelopment, but it is not clear if these associations are explained by shared familiar characteristics. We aimed to assess the associations of maternal and paternal obesity, maternal glucose intolerance in early pregnancy and GDM, with offspring neurodevelopment at 4 years of age. We included 772 mother-child pairs from the "Rhea" Mother-Child cohort in Crete, Greece. Data on maternal/paternal body mass index (BMI) and maternal fasting serum samples for glucose and insulin measurements were collected at 12 weeks of gestation...
January 3, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28050671/adiponectin-and-leptin-gene-polymorphisms-in-women-with-gestational-diabetes-mellitus
#11
Andrzej Pawlik, Joanna Teler, Agnieszka Maciejewska, Marek Sawczuk, Krzysztof Safranow, Violetta Dziedziejko
PURPOSE: Gestational diabetes mellitus (GDM) is the glucose intolerance occurring during pregnancy. The prevalence of GDM is increased in obese women. Leptin and adiponectin are adipokines that play an important role in the regulation of insulin secretion and glucose and lipid metabolism. The aim of this study was to examine the association between adiponectin and leptin gene polymorphisms and the development of GDM. METHODS: This case-control study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT)...
January 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28049284/prevention-of-type-2-diabetes-mellitus-in-women-with-previous-gestational-diabetes-mellitus
#12
REVIEW
Joon Ho Moon, Soo Heon Kwak, Hak C Jang
Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset or first recognition during pregnancy, is characterized by underlying maternal defects in the β-cell response to insulin during pregnancy. Women with a previous history of GDM have a greater than 7-fold higher risk of developing postpartum diabetes compared with women without GDM. Various risk factors for postpartum diabetes have been identified, including maternal age, glucose levels in pregnancy, family history of diabetes, pre-pregnancy and postpartum body mass index, dietary patterns, physical activity, and breastfeeding...
January 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28040126/prediction-of-gestational-diabetes-mellitus-at-first-trimester-in-low-risk-pregnancies
#13
Pınar Kumru, Resul Arisoy, Emre Erdogdu, Oya Demirci, Mustecep Kavrut, Cem Ardıc, Nihan Aslaner, Aysen Ozkoral, Aktug Ertekin
OBJECTIVE: We aimed to assess the relationship among the sex hormone-binding globulin (SHBG), homeostasis model assessment (HOMA), glycosylated hemoglobin (HbA1c), and cholesterol panel values to predict subsequent gestational diabetes mellitus (GDM) in low-risk pregnancies. MATERIALS AND METHODS: Thirty-eight pregnant women with GDM and 295 low-risk pregnant women without GDM were included in this study. Maternal blood samples were obtained during the first trimester examination to determine the SHBG, HbA1c, fasting blood glucose, insulin, thyroid stimulating hormone (TSH), free thyroxine, total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL-C) levels...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28035763/circulating-milk-fat-globule-epidermal-growth-factor-8-levels-are-increased-in-pregnancy-and-gestational-diabetes-mellitus
#14
Yuanyuan Li, Wenzhuo Ran, Jiaqiang Zhang, Shi Chen, Yihang Li, Deng Luo, Chen Wang, Weiping Jia
AIMS/INTRODUCTION: Milk fat globule-epidermal growth factor 8 (MFG-E8) is the key mediator in anti-inflammatory responses that facilitate phagocytosis of apoptotic cells and play an essential role in type 2 diabetes and pregnancy, both of which are under a low-grade inflammatory state. However, the action of MFG-E8 in gestational diabetes mellitus (GDM) is unclear. We measured for the first time plasma MFG-E8 levels in pregnancy and GDM, and elucidated possible relationships between its plasma levels and various metabolic parameters...
December 30, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28026897/pregnancy-outcome-of-gestational-diabetes-mellitus-using-a-structured-model-of-care-wings-project-wings-10
#15
Ram Uma, Balaji Bhavadharini, Harish Ranjani, Manni Mohanraj Mahalakshmi, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Arivudainambi Kayal, Belma Malanda, Anne Belton, Viswanathan Mohan
AIM: To evaluate the impact of a structured model of care (MOC) prepared for resource-constrained settings, on the pregnancy outcomes of Asian Indian women with gestational diabetes mellitus (GDM). METHODS: Pregnant women were screened under the Women in India with GDM Strategy (WINGS) MOC for GDM using the International Association of Diabetes and Pregnancy Study Groups criteria. Women with GDM went through a structured MOC that included medical nutrition therapy (MNT), regular physical activity (PA); and insulin when indicated...
December 27, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28024145/calorie-restriction-prevents-the-development-of-insulin-resistance-and-impaired-lipid-metabolism-in-gestational-diabetes-offspring
#16
Tao Li, Keyang Chen, Gang Liu, Li-Ping Huang, Long Chen, Qiu-Wei Wang, Chuan-Lai Hu, Li-Juan Hou
BackgroundGestational diabetes mellitus (GDM) has long-lasting influence on offspring, which is associated with increased risks of insulin resistance, obesity and type II diabetes mellitus. Calorie restriction (CR) is one of the most common and available nutritional interventions to prevent obesity and diabetes. We are trying to explore the effect of CR on GDM offspring.MethodsThe streptozotocin was used to stimulate C57BL/6J mice to develop GDM, a number of metabolic characteristics and related protein expression were determined in GDM offspring that were fed ad-libitum or treated with calorie restriction...
December 26, 2016: Pediatric Research
https://www.readbyqxmd.com/read/28017702/arsenite-in-drinking-water-produces-glucose-intolerance-in-pregnant-rats-and-their-female-offspring
#17
María Marta Bonaventura, Nadia Soledad Bourguignon, Marianne Bizzozzero, Diego Rodriguez, Clara Ventura, Claudia Cocca, Carlos Libertun, Victoria Adela Lux-Lantos
Drinking water is the main source of arsenic exposure. Chronic exposure has been associated with metabolic disorders. Here we studied the effects of arsenic on glucose metabolism, in pregnant and post-partum of dams and their offspring. We administered 5 (A5) or 50 (A50) mg/L of sodium arsenite in drinking water to rats from gestational day 1 (GD1) until two months postpartum (2MPP), and to their offspring from weaning until 8 weeks old. Liver arsenic dose-dependently increased in arsenite-treated rats to levels similar to exposed population...
December 23, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27995150/risk-factors-for-the-requirement-of-antenatal-insulin-treatment-in-gestational-diabetes-mellitus
#18
Mayu Watanabe, Akihiro Katayama, Hidetoshi Kagawa, Daisuke Ogawa, Jun Wada
Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in the pregnant women with GDM. We enrolled 37 pregnant women with GDM and investigated the risk for AIT by comparing the patients with AIT (AIT group; n = 10) and without insulin therapy (Diet group; n = 27)...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27990086/are-adipokines-associated-with-gestational-diabetes-mellitus
#19
Ümit Görkem, Ferit Kerim Küçükler, Cihan Toğrul, Tayfun Güngör
OBJECTIVE: To investigate the association of maternal serum levels of chemerin, retinol binding protein-4 (RBP-4), and visfatin with gestational diabetes mellitus (GDM). MATERIAL AND METHODS: 158 pregnant women were screened between 24 and 28 weeks of gestation. They were divided into two groups: GDM group (n=76) and control group (n=82). Maternal serum concentrations of chemerin, RBP-4, visfatin, insulin, and homeostasis model assessment-insulin resistance (HOMA-IR) were assessed...
2016: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/27989238/the-effects-of-synbiotic-supplementation-on-markers-of-insulin-metabolism-and-lipid-profiles-in-gestational-diabetes-a-randomized-double-blind-placebo-controlled-trial-corrigendum
#20
Shahnaz Ahmadi, Mehri Jamilian, Maryam Tajabadi-Ebrahimi, Parvaneh Jafari, Zatollah Asemi
No abstract text is available yet for this article.
December 2016: British Journal of Nutrition
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