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https://www.readbyqxmd.com/read/28644881/gestational-diabetes-mellitus-and-risk-of-type-2-diabetes-10-years-after-the-index-pregnancy-in-sri-lankan-women-a-community-based-retrospective-cohort-study
#1
Himali Herath, Rasika Herath, Rajitha Wickremasinghe
BACKGROUND: Women with a history of gestational diabetes mellitus (GDM) have an increased risk of type 2 diabetes mellitus (T2DM) later in life compared to women with no GDM. This study was aimed to determine the risk of developing T2DM 10 years after GDM in Sri Lankan women. METHODS: A retrospective cohort study was conducted in the Colombo district, Sri Lanka. 7205 women who delivered a child in 2005 were identified through Public Health Midwives in the field...
2017: PloS One
https://www.readbyqxmd.com/read/28641781/pregnancy-to-postpartum-transition-of-serum-metabolites-in-women-with-gestational-diabetes
#2
Elin Chorell, Ulrika Andersson Hall, Carolina Gustavsson, Kerstin Berntorp, Jatta Puhkala, Riitta Luoto, Tommy Olsson, Agneta Holmäng
CONTEXT: Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. OBJECTIVE: To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. DESIGN: The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28637888/maternal-bmi-and-glycemia-impact-the-fetal-metabolome
#3
William L Lowe, James R Bain, Michael Nodzenski, Anna C Reisetter, Michael J Muehlbauer, Robert D Stevens, Olga R Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, Denise M Scholtens
OBJECTIVE: We used targeted metabolomics to determine associations of maternal BMI and glucose levels with cord blood metabolites and associations of cord blood metabolites with newborn birth weight and adiposity in mother-offspring dyads. RESEARCH DESIGN AND METHODS: Targeted metabolomic assays were performed on cord blood serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American newborns (400 from each ancestry group) whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and who had anthropometric measurements at birth...
July 2017: Diabetes Care
https://www.readbyqxmd.com/read/28637315/attenuated-effects-of-bile-acids-on-glucose-metabolism-and-insulin-sensitivity-in-a-male-mouse-model-of-prenatal-undernutrition
#4
Huijuan Ma, Vicencia M Sales, Ashley R Wolf, Sathish Subramanian, Tucker J Matthews, Michael Chen, Aparna Sharma, Walt Gall, Wim Kulik, David E Cohen, Yusuke Adachi, Nicholas W Griffin, Jeffrey I Gordon, Mary-Elizabeth Patti, Elvira Isganaitis
Prenatal undernutrition and low birth weight are associated with risk of type 2 diabetes and obesity. Prenatal caloric restriction results in low birth weight, glucose intolerance, obesity, and reduced plasma bile acids (BA) in offspring mice. Since BAs can regulate systemic metabolism and glucose homeostasis, we hypothesized that BA supplementation could prevent diet-induced obesity and glucose intolerance in this model of developmental programming. Pregnant dams were food restricted by 50% from gestational days 12...
June 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28636750/comparison-of-serum-vaspin-levels-and-vaspin-expression-in-adipose-tissue-and-smooth-muscle-tissue-in-pregnant-women-with-and-without-gestational-diabetes
#5
Yuping Tang, Ping Qiao, Xiaoxian Qu, Yirong Bao, Yuhong Li, Yini Liao, Hao Ying
OBJECTIVE: Vaspin is associated with metabolic parameters and insulin resistance. However, the expression of vaspin in visceral adipose tissue (VAT) in pregnant women with gestational diabetes mellitus (GDM) has not been fully explored, and the contribution of vaspin to the biological mechanisms underlying GDM remains unclear. This study aimed to compare circulating vaspin levels and its expression in different insulin target tissues including subcutaneous adipose tissue (SAT), VAT, and smooth muscle tissue (SMT) in pregnant women with and without GDM...
June 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28628847/the-importance-of-declining-insulin-requirements-during-pregnancy-in-patients-with-pre-gestational-gestational-diabetes-mellitus
#6
Maya Ram, Larissa Feinmesser, Shiri Shinar, Sharon Maslovitz
OBJECTIVE: In patients with pre-gestational and gestational diabetes mellitus (GDM), insulin requirements often increase during the third trimester of pregnancy in order to maintain proper glycemic control. However, a fraction of patients demonstrate a significant decrease in insulin requirements in late gestation. We aimed to evaluate the clinical significance of decreasing insulin requirements in patients with pre-gestational diabetes and GDM with respect to fetal wellbeing and pregnancy outcome...
June 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28624989/ponderal-index-at-birth-associates-with-later-risk-of-gestational-diabetes-mellitus
#7
Mie Crusell, Peter Damm, Torben Hansen, Oluf Pedersen, Charlotte Glümer, Allan Vaag, Jeannet Lauenborg
PURPOSE: Low birth weight (BW) and low ponderal index (PI) are associated with increased risk of type 2 diabetes mellitus. This study has two purposes: first to investigate the influence of PI on the risk of gestational diabetes mellitus (GDM); second, to study the association between glucose metabolism and BW in women with previous GDM. METHODS: GDM cohort: 185 women with GDM in 1978-1996, attending a follow-up study in 2000-2002. Control cohort: 1137 women from a population-based diabetes screening study (Inter99) in a neighbouring county in 1999-2001...
June 17, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28621051/plasma-microrna-16-5p-17-5p-and-20a-5p-novel-diagnostic-biomarkers-for-gestational-diabetes-mellitus
#8
Ya-Lei Cao, Yan-Ju Jia, Bao-Heng Xing, Dan-Dan Shi, Xiu-Juan Dong
AIM: To explore whether plasma microRNA-16-5p, -17-5p and -20a-5p can be used as diagnostic biomarkers in gestational diabetes mellitus (GDM) and to investigate the relationship between those microRNAs and the risk factors of GDM (body mass index [BMI], insulin resistance [IR] and tumor necrosis factor-α (TNF-α)). METHODS: A total of 85 pregnant women with GDM and 72 pregnant women without GDM were enrolled in this study. The plasma concentration of microRNAs (microRNA-16-5p, -17-5p, -19a-3p, -19b-3p, -20a-5p) was measured using quantitative reverse transcription-polymerase chain reaction (qRT-PCR)...
June 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28617561/cervicovaginal-bacteria-and-fungi-in-pregnant-diabetic-and-non-diabetic-women-a-multicenter-observational-cohort-study
#9
A Lukic, A Napoli, I Santino, P Bianchi, F Nobili, G Ciampittiello, M R Nardone, M Santomauro, M Di Properzio, D Caserta
OBJECTIVE: We evaluated the prevalence of cervicovaginal Bacteria, group B Streptococcus (GBS), Gardnerella vaginalis (GV), Candida spp., Chlamydia trachomatis (CT), Mycoplasma hominis (MH) and Ureaplasma urealyticum (UU) in pregnant women with and without diabetes mellitus (DM). PATIENTS AND METHODS: Cervicovaginal swabs were gathered from 473 pregnant patients divided into 127 diabetic and 346 non-diabetic. The results were correlated to gestational age, parity and glycemic control...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28616923/-effects-of-tramadol-on-insulin-resistance-during-cesarean-section-complicated-with-gestational-diabetes-mellitus
#10
Yuan-Gui Lin, Wei Huang
OBJECTIVES: To investigate the effects of tramadol on insulin resistance (IR) during cesarean section complicated with gestational diabetes mellitus (GDM). METHODS: 120 patients of elective caesarean sectioncomplicated with GDM (level A1) were collected from Dec.2015 to Oct.2016, randomly divided into the tramadol injection treated groups (0.5 mg/kg-TRM1, 1 mg/kg-TRM2 and 1.5 mg/kg-TRM3) and the control group (CON) (n=30). The patients of TRM groups were injected with tramadol after delivery of fetus during caesarean delivery under combined spinal-epidural anaesthesia (CSEA) and the patients of CON group were treated with normal saline as control...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28596534/circulating-3-carboxy-4-methyl-5-propyl-2-furanpropanoic-acid-cmpf-levels-are-associated-with-hyperglycemia-and-%C3%AE-cell-dysfunction-in-a-chinese-population
#11
Shan Zhang, Peihong Chen, Hua Jin, Jufen Yi, Xinmiao Xie, Meili Yang, Ting Gao, Lili Yang, Cheng Hu, Xueli Zhang, Xuemei Yu
Several recent clinical studies have suggested that the levels of circulating 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) are significantly higher in patients with gestational diabetes mellitus (GDM), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM). This study recruited a total of 516 participants. The following patient populations were enrolled: 99 newly diagnosed cases with T2DM, 219 cases with prediabetes [82 with isolated impaired glucose tolerance (I - IGT), 66 with isolated impaired fasting glucose (I - IFG) and 71 with impaired glucose tolerance and impaired fasting glucose (IGT + IFG)], and 198 cases with normal glucose tolerance [NGT, including 99 first-degree relatives of type 2 diabetes patients (FDRs) and 99 non-FDRs]...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28587267/insulin-treatment-may-alter-fatty-acid-carriers-in-placentas-from-gestational-diabetes-subjects
#12
Maria Ruiz-Palacios, Maria Teresa Prieto-Sánchez, Antonio José Ruiz-Alcaraz, José Eliseo Blanco-Carnero, Maria Sanchez-Campillo, Juan José Parrilla, Elvira Larqué
There is little information available on the effect of Gestational diabetes mellitus (GDM) treatment (diet or insulin) on placental lipid carriers, which may influence fetal fat accretion. Insulin may activate placental insulin receptors protein kinase (AKT) and extracellular signal regulated kinase ERK mediators, which might affect lipid metabolism. Placenta was collected from 25 control women, 23 GDM-Diet and 20 GDM-Insulin. Western blotting of insulin signaling mediators and lipid carriers was performed...
June 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28586507/patterns-of-glucose-lowering-therapies-and-neonatal-outcomes-in-the-treatment-of-gestational-diabetes-in-canada-2009-2014
#13
S L Bowker, A Savu, R O Yeung, J A Johnson, E A Ryan, P Kaul
AIM: To examine patterns of use of different glycaemic control agents for treating gestational diabetes mellitus. METHODS: This was a large, retrospective, population-based cohort study of pregnant women with gestational diabetes from Alberta, Canada. We linked data from the Alberta Vital Statistics - Birth database with administrative claims data. Alberta Vital Statistics - Birth data were used to identify births that occurred between 1 January 2009 and 31 December 2014...
June 6, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28580448/serum-ferritin-concentration-in-early-pregnancy-and-risk-of-subsequent-development-of-gestational-diabetes-a-prospective-study
#14
Sedigheh Soheilykhah, Mahdieh Mojibian, Maryam Jannati Moghadam
BACKGROUND: Elevated serum ferritin concentration is associated with insulin resistance and diabetes. Recently it has also been described in gestational diabetes mellitus (GDM). OBJECTIVE: A prospective study was done to determine whether there was a relationship between serum ferritin concentration in early pregnancy and the risk of GDM. MATERIALS AND METHODS: A study was performed on 1,384 pregnant women with gestational age of 12-16 weeks...
March 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28577545/the-effect-of-a-prenatal-lifestyle-intervention-on-glucose-metabolism-results-of-the-norwegian-fit-for-delivery-randomized-controlled-trial
#15
Linda R Sagedal, Ingvild Vistad, Nina C Øverby, Elling Bere, Monica K Torstveit, Hilde Lohne-Seiler, Elisabet R Hillesund, Are Pripp, Tore Henriksen
BACKGROUND: The effectiveness of prenatal lifestyle intervention to prevent gestational diabetes and improve maternal glucose metabolism remains to be established. The Norwegian Fit for Delivery (NFFD) randomized, controlled trial studied the effect of a combined lifestyle intervention provided to a general population, and found significantly lower gestational weight gain among intervention participants but no improvement in obstetrical outcomes or the proportion of large infants. The aim of the present study is to examine the effect of the NFFD intervention on glucose metabolism, including an assessment of the subgroups of normal-weight and overweight/obese participants...
June 2, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28577154/association-of-endometrial-hyperplasia-and-cancer-with-a-history-of-gestational-diabetes
#16
Paige D Wartko, Tiffany L Beck, Susan D Reed, Beth A Mueller, Stephen E Hawes
PURPOSE: Excess circulating insulin may contribute to endometrial cancer (EC) development; studies suggest increased risk of EC associated with type 2 diabetes. We investigated whether gestational diabetes is associated with increased risk of EC and its precursor, endometrial hyperplasia (EH). METHODS: We conducted a population-based, case-control study of women in Washington State. Cases were women with a hospital discharge record indicating the presence of EH/EC who could be linked to a prior delivery hospitalization or birth record from 1987 to 2013 (n = 593)...
June 2, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28572303/maternal-exercise-improves-glucose-tolerance-in-female-offspring
#17
Kristin I Stanford, Hirokazu Takahashi, Kawai So, Ana Barbara Alves-Wagner, Noah B Prince, Adam C Lehnig, Kristen M Getchell, Min-Young Lee, Michael F Hirshman, Laurie J Goodyear
Poor maternal diet can lead to metabolic disease in offspring whereas maternal exercise may have beneficial effects on offspring health. Here, we determined if maternal exercise could reverse the detrimental effects of maternal high fat feeding on offspring metabolism of female mice. C57BL/6 female mice were fed a chow (21%) or high-fat (60%) diet and further divided by housing in static cages or cages with running wheels for 2 weeks prior to breeding and throughout gestation. Females were bred with chow-fed sedentary C57BL/6 males...
June 1, 2017: Diabetes
https://www.readbyqxmd.com/read/28571777/postpartum-screening-practices-progression-to-abnormal-glucose-tolerance-and-its-related-risk-factors-in-asian-women-with-a-known-history-of-gestational-diabetes-a-systematic-review-and-meta-analysis
#18
REVIEW
Sedigheh Nouhjah, Hajieh Shahbazian, Neda Amoori, Shayesteh Jahanfar, Nahid Shahbazian, Alireza Jahanshahi, Bahman Cheraghian
AIMS: Rate of postpartum screening and progression to glucose intolerance (diabetes and/or pre-diabetes) in Asian women with prior GDM and risk factors of diversion to abnormal glucose tolerance were reviewed. MATERIALS AND METHODS: We searched Pub Med, Cochrane Library, Web of Science, EMBASE, and Ovid data base. About 1300 studies were screened and 27 articles were selected. Meta-analysis using Comprehensive Meta -Analysis software was conducted. All results were reported at the pooled ORs and 95% CI...
May 24, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28556992/management-of-sulfonylurea-treated-monogenic-diabetes-in-pregnancy-implications-of-placental-glibenclamide-transfer
#19
REVIEW
M Shepherd, A J Brook, A J Chakera, A T Hattersley
The optimum treatment for HNF1A/HNF4A maturity-onset diabetes of the young and ATP-sensitive potassium (KATP ) channel neonatal diabetes is sulfonylureas outside pregnancy, but there is little evidence regarding the most appropriate treatment during pregnancy. Glibenclamide has been widely used in the treatment of gestational diabetes, but recent data have established that glibenclamide crosses the placenta and increases risk of macrosomia and neonatal hypoglycaemia. This raises questions about its use in pregnancy...
May 30, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28555324/low-maternal-circulating-levels-of-vitamin-d-as-potential-determinant-in-the-development-of-gestational-diabetes-mellitus
#20
REVIEW
S Triunfo, A Lanzone, P G Lindqvist
Gestational diabetes mellitus (GDM), defined as any glucose intolerance with the onset or first recognition during pregnancy, is characterized by rising incidence, fostered by the worldwide increase of pathological nutritional status from young age. Clinical research has intended to identify potential risk factors, suggested improvements in screening strategies, and recommended the combination between promotion of an appropriate lifestyle before and during pregnancy and selected therapeutic approaches. Preventing pathological hyperglycemia could have several benefits, ranging from clinical side (reduction in the risk of adverse perinatal and long-term sequelae) to financial side (cost reduction to healthcare systems)...
May 29, 2017: Journal of Endocrinological Investigation
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