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https://www.readbyqxmd.com/read/29774465/effect-of-inositol-stereoisomers-at-different-dosages-in-gestational-diabetes-an-open-label-parallel-randomized-controlled-trial
#1
Federica Fraticelli, Claudio Celentano, Isaia Al Zecca, Giacoma Di Vieste, Basilio Pintaudi, Marco Liberati, Marica Franzago, Marta Di Nicola, Ester Vitacolonna
AIMS: Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women. METHODS: Participants were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg D-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27...
May 17, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29764499/gestational-diabetes-is-associated-with-change-in-the-gut-microbiota-composition-in-third-trimester-of-pregnancy-and-postpartum
#2
Mie Korslund Wiinblad Crusell, Tue Haldor Hansen, Trine Nielsen, Kristine Højgaard Allin, Malte C Rühlemann, Peter Damm, Henrik Vestergaard, Christina Rørbye, Niklas Rye Jørgensen, Ole Bjarne Christiansen, Femke-Anouska Heinsen, Andre Franke, Torben Hansen, Jeannet Lauenborg, Oluf Pedersen
BACKGROUND: Imbalances of gut microbiota composition are linked to a range of metabolic perturbations. In the present study, we examined the gut microbiota of women with gestational diabetes mellitus (GDM) and normoglycaemic pregnant women in late pregnancy and about 8 months postpartum. METHODS: Gut microbiota profiles of women with GDM (n = 50) and healthy (n = 157) pregnant women in the third trimester and 8 months postpartum were assessed by 16S rRNA gene amplicon sequencing of the V1-V2 region...
May 15, 2018: Microbiome
https://www.readbyqxmd.com/read/29750952/glucostabilizer%C3%A2-software-guided-insulin-dosing-improves-intrapartum-glycemic-management-in-women-with-diabetes
#3
Cheryl Dinglas, Jolene Muscat, Tracy Adams, Virginia Peragallo-Dittko, Anthony Vintzileos, Hye J Heo
BACKGROUND: During labor, maintenance of maternal euglycemia is critical to decrease the risk of neonatal hypoglycemia and associated morbidities. When continuous intravenous insulin infusion is needed, standardized insulin dosing charts have been used for titration of insulin to maintain glucose in target range. GlucoStabilizer™ is a software-guided insulin dosing system that calculates the dose of intravenous insulin needed based on metabolic parameters, target glucose concentration, and an individual's response to insulin...
May 8, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29749110/metformin-for-the-prevention-of-hypertensive-disorders-of-pregnancy-in-women-with-gestational-diabetes-and-obesity-a-systematic-review-and-meta-analysis
#4
REVIEW
Erkan Kalafat, Yavuz Emre Sukur, Abdulkadir, Basky Thilaganathan, Asma Khalil
OBJECTIVES: Metformin has been reported to reduce the risk of preeclampsia. It is also known to influence soluble fms-like tyrosine kinase-1 (sFlt-1) levels, which correlate significantly with the gestation of onset and severity of preeclampsia. The main aim of this systematic review and meta-analysis was to determine whether metformin use is associated with the incidence of hypertensive disorders of pregnancy (HDP). METHODS: MEDLINE (1947 - September 2017), Scopus (1970 - September 2017) and the Cochrane Library (since inception - September 2017) were searched for relevant citations in English language...
May 10, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29747601/pregnancy-outcomes-in-women-with-gestational-diabetes-mellitus-diagnosed-according-to-the-who-2013-and-who-1999-diagnostic-criteria-a-multicentre-retrospective-cohort-study
#5
Eva A R Goedegebure, Sarah H Koning, Klaas Hoogenberg, Fleurisca J Korteweg, Helen L Lutgers, Mattheus J M Diekman, Eva Stekkinger, Paul P van den Berg, Joost J Zwart
BACKGROUND: The World Health Organization (WHO) adopted more stringent diagnostic criteria for GDM in 2013, to improve pregnancy outcomes. However, there is no global consensus on these new diagnostic criteria, because of limited evidence. The objective of the study was to evaluate maternal characteristics and pregnancy outcomes in two cohorts in the Netherlands applying different diagnostic criteria for GDM i.e. WHO-2013 and WHO-1999. METHODS: A multicenter retrospective study involving singleton GDM pregnancies in two regions, between 2011 and 2016...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29745913/benefits-of-early-screening-and-proper-treatment-in-patient-with-significant-risk-factors-for-gestational-diabetes-mellitus-case-report
#6
V Limani
Gestational diabetes mellitus (GDM) occurs in 2-9% of all pregnancies. Evidence suggests that the use of insulin in treating hyperglycemia in GDM patients reduces the risk of perinatal morbidity. Pregnancy is an exciting time in a woman's life. However, once patient is diagnosed with GDM, she will be managed more intensively. GDM is managed using diet and exercise but one in six women with GDM requires insulin. A 35-year-old woman at the 14th gestational week of her tenth pregnancy was seen for routine prenatal care...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29744612/maternal-non-glycemic-contributors-to-fetal-growth-in-obesity-and-gestational-diabetes-spotlight-on-lipids
#7
REVIEW
Linda A Barbour, Teri L Hernandez
PURPOSE OF REVIEW: Excess fetal growth is increasingly recognized as a risk factor for childhood obesity, and mounting evidence supports that maternal glucose is not the only driver. This review focuses on the role of clinically applicable maternal non-glycemic contributors to excess fetal growth, particularly lipids, in addition to amino acids (AA), insulin resistance, inflammation, maternal nutrition, and gestational weight gain (GWG) in obesity and gestational diabetes mellitus (GDM)...
May 9, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29743342/the-role-of-obesity-and-adipose-tissue-dysfunction-in-gestational-diabetes-mellitus
#8
Patrik Šimják, Anna Cinkajzlová, Kateřina Anderlová, Antonín Pařízek, Milos Mraz, Michal Kršek, Martin Haluzik
Gestational diabetes mellitus is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation. It is the most common complication of pregnancy. The underlying pathophysiology shares some common features with type 2 diabetes mellitus combining relatively insufficient insulin secretion with increased peripheral insulin resistance. While a certain degree of insulin resistance is the physiological characteristics of the second half of pregnancy, it is significantly more pronounced in patients with gestational diabetes...
May 9, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29740395/maternal-diet-metabolic-state-and-inflammatory-response-exert-unique-and-long-lasting-influences-on-offspring-behavior-in-non-human-primates
#9
Jacqueline R Thompson, Hanna C Gustafsson, Madison DeCapo, Diana L Takahashi, Jennifer L Bagley, Tyler A Dean, Paul Kievit, Damien A Fair, Elinor L Sullivan
Nutritional status influences brain health and gestational exposure to metabolic disorders (e.g. obesity and diabetes) increases the risk of neuropsychiatric disorders. The aim of the present study was to further investigate the role of maternal Western-style diet (WSD), metabolic state, and inflammatory factors in the programming of Japanese macaque offspring behavior. Utilizing structural equation modeling, we investigated the relationships between maternal diet, prepregnancy adiposity, third trimester insulin response, and plasma cytokine levels on 11-month-old offspring behavior...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29740234/associations-of-spexin-and-cardiometabolic-parameters-among-women-with-and-without-gestational-diabetes-mellitus
#10
Nasser M Al-Daghri, Hazim A Al-Hazmi, Abdulrahman Al-Ajlan, Mohammad S Masoud, Abeer Al-Amro, Amani Al-Ghamdi, Abdullah M Alnaami, Omar S Al-Attas, Majed S Alokail
Spexin (SPX) is a novel biomarker abundantly expressed in several animal and human tissues implicated in food intake and glucose control, respectively. As new roles for SPX are emerging, the present study explored for the first time, the associations of SPX to several cardiometabolic indices and inflammatory markers in pregnant women, a demographic not yet investigated with respect to SPX. A total of 117 Saudi women subdivided to those with gestational diabetes mellitus (GDM) (N = 63) and those without (N = 54) were included in this cross-sectional study...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29736403/temporal-trends-in-gestational-diabetes-prevalence-treatment-and-outcomes-at-aarhus-university-hospital-skejby-between-2004-and-2016
#11
Per Glud Ovesen, Jens Fuglsang, Mette Bisgaard Andersen, Charlotte Wolff, Olav Bjørn Petersen, H David McIntyre
Background: The prevalence of gestational diabetes (GDM) is increasing worldwide. The most important risk of GDM in pregnancy is excessive fetal growth, increasing the risk of complications during delivery as well as long-term complications like obesity and diabetes in both the mother and the offspring. Method: All women with GDM who delivered a singleton between 2004 and 2016 were included. The treatment of GDM patients sought to achieve normal blood glucose levels, primarily by diet and exercise...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29730391/pharmacotherapy-for-hyperglycemia-in-pregnancy-the-new-insulins
#12
REVIEW
Yoel Toledano, Eran Hadar, Moshe Hod
Hyperglycemia in pregnancy may lead to adverse maternal, fetal and neonatal outcomes. Tight glycemic control is prudent in order to reduce pregnancy complications. For many years, the gold standard pharmacological therapy during pregnancy was human insulin. Recently, insulin analogues were also introduced to clinical use in pregnancy. This brief review aims to summarize the information on the efficacy and safety of insulin analogue therapy during gestation. The strengths and pitfalls of insulin analogue administration during gestation, compared with human insulin, are presented...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29730292/altered-expression-of-pgc-1%C3%AE-and-pdx1-and-their-methylation-status-are-associated-with-fetal-glucose-metabolism-in-gestational-diabetes-mellitus
#13
Lizhen Wang, Hailing Fan, Ludan Zhou, Yanjun Wu, Hongping Lu, Jing Luo
PURPOSE: To investigate the effect of gestational diabetes mellitus (GDM) on the expression and methylation of PGC-1α and PDX1 in placenta and their effects on fetal glucose metabolism. METHODS: 20 cases of full-term placenta without pregnancy complications and umbilical cord abnormalities and 20 cases of GDM group were collected. DNA and RNA were isolated from samples of tissue collected from the fetal side of the placenta immediately after delivery. DNA methylation was quantified at 7 CpG sites within the PGC-1α and PDX1 genes using PCR amplification of bisulfite treated DNA and subsequent DNA sequencing...
May 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29724492/first-trimester-abdominal-adipose-tissue-thickness-to-predict-gestational-diabetes
#14
Mélodie Bourdages, Marie-Élaine Demers, Samuel Dubé, Cédric Gasse, Mario Girard, Amélie Boutin, Joel G Ray, Emmanuel Bujold, Suzanne Demers
OBJECTIVE: To estimate the discriminative capacity of first-trimester subcutaneous (SATT), visceral (VATT), and total (TATT) adipose tissue thickness in predicting gestational diabetes mellitus (GDM), including that requiring insulin. METHODS: We prospectively recruited a cohort of 1048 nulliparous women. Ultrasound images were used to determine abdominal SATT, VATT, and TATT at 11 to 14 weeks' gestation. Multivariate logistic regression models were used to predict GDM, as well as insulin-requiring GDM...
April 30, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29717618/glucocorticoid-signaling-enhances-expression-of-glucose-sensing-molecules-in-immature-pancreatic-beta-like-cells-derived-from-murine-embryonic-stem-cells-in-vitro
#15
Nadiah Ghazalli, Xiaoxing Wu, Stephanie Walker, Nancy Trieu, Li-Yu Hsin, Justin Choe, Chialin Chen, Jasper Hsu, Jeanne LeBon, Mark T Kozlowski, Jeffrey Rawson, David A Tirrell, M L Richard Yip, Hsun Teresa Ku
Pluripotent stem cells may serve as an alternative source of beta-like cells for replacement therapy of type 1 diabetes; however, the beta-like cells generated in many differentiation protocols are immature. The maturation of endogenous beta cells involves an increase in insulin expression starting in late gestation and a gradual acquisition of the abilities to sense glucose and secrete insulin by week 2 after birth in mice; however, what molecules regulate these maturation processes are incompletely known...
May 2, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29716559/health-behaviour-changes-in-partners-of-women-with-recent-gestational-diabetes-a-phase-iia-trial
#16
Anne-Sophie Brazeau, Sara J Meltzer, Romina Pace, Natasha Garfield, Ariane Godbout, Leslie Meissner, Elham Rahme, Deborah Da Costa, Kaberi Dasgupta
BACKGROUND: We recently demonstrated that a gestational diabetes history in mothers is associated with higher postpartum incident diabetes not only in mothers but also in fathers. In the present study, we examined changes in health behaviours and cardiometabolic profiles in both mothers and partners who participated in a diabetes prevention program within 5 years of a gestational diabetes pregnancy. METHODS: Couples were enrolled into a 13-week program that included 5 half-day group sessions and web/telephone-based support between sessions...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29715355/effect-of-glyburide-vs-subcutaneous-insulin-on-perinatal-complications-among-women-with-gestational-diabetes-a-randomized-clinical-trial
#17
Marie-Victoire Sénat, Helene Affres, Alexandra Letourneau, Magali Coustols-Valat, Marie Cazaubiel, Helene Legardeur, Julie Fort Jacquier, Nathalie Bourcigaux, Emmanuel Simon, Anne Rod, Isabelle Héron, Virginie Castera, Loic Sentilhes, Florence Bretelle, Catherine Rolland, Mathieu Morin, Philippe Deruelle, Celine De Carne, François Maillot, Gael Beucher, Eric Verspyck, Raoul Desbriere, Sandrine Laboureau, Delphine Mitanchez, Jean Bouyer
Importance: Randomized trials have not focused on neonatal complications of glyburide for women with gestational diabetes. Objective: To compare oral glyburide vs subcutaneous insulin in prevention of perinatal complications in newborns of women with gestational diabetes. Design, Settings, and Participants: The Insulin Daonil trial (INDAO), a multicenter noninferiority randomized trial conducted between May 2012 and November 2016 (end of participant follow-up) in 13 tertiary care university hospitals in France including 914 women with singleton pregnancies and gestational diabetes diagnosed between 24 and 34 weeks of gestation...
May 1, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29715338/insulin-vs-glyburide-for-gestational-diabetes
#18
EDITORIAL
Donald R Coustan, Linda Barbour
No abstract text is available yet for this article.
May 1, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29712720/metabolic-disorders-during-pregnancy-and-postpartum-cardiometabolic-risk
#19
Angelo Maria Patti, Kalliopi Pafili, Nikolaos Papanas, Manfredi Rizzo
Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter lead to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia...
April 30, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29709497/reduced-cortical-excitability-neuroplasticity-and-salivary-cortisol-in-11-13-year-old-children-born-to-women-with-gestational-diabetes-mellitus
#20
Jago M Van Dam, Amy J Garrett, Luke A Schneider, Nicolette A Hodyl, Mitchell R Goldsworthy, Suzette Coat, Janet A Rowan, William M Hague, Julia B Pitcher
BACKGROUND: Children exposed to gestational diabetes mellitus (GDM) in utero are at increased risk of neurodevelopmental difficulties, including autism and impaired motor control. However, the underlying neurophysiology is unknown. METHODS: Using transcranial magnetic stimulation, we assessed cortical excitability, long-term depression (LTD)-like neuroplasticity in 45 GDM-exposed and 12 control children aged 11-13 years. Data were analysed against salivary cortisol and maternal diabetes severity and treatment (insulin [N = 22] or metformin [N = 23]) during pregnancy...
April 10, 2018: EBioMedicine
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