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https://www.readbyqxmd.com/read/28410978/performance-monitoring-in-nicotine-dependence-considering-integration-of-recent-reinforcement-history
#1
Kevin Butler, Jennifer Rusted, Paul Gard, Anne Jackson
INTRODUCTION: Impaired monitoring of errors and conflict (performance monitoring; PM) is well documented in substance dependence (SD) including nicotine dependence and may contribute to continued drug use. Contemporary models of PM and complementary behavioural evidence suggest that PM works by integrating recent reinforcement history rather than evaluating individual behaviours. Despite this, studies of PM in SD have typically used indices derived from reaction to task error or conflict on individual trials...
April 11, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28403383/neural-signatures-of-cognitive-flexibility-and-reward-sensitivity-following-nicotinic-receptor-stimulation-in-dependent-smokers-a-randomized-trial
#2
Elise Lesage, Sarah E Aronson, Matthew T Sutherland, Thomas J Ross, Betty Jo Salmeron, Elliot A Stein
Importance: Withdrawal from nicotine is an important contributor to smoking relapse. Understanding how reward-based decision making is affected by abstinence and by pharmacotherapies such as nicotine replacement therapy and varenicline tartrate may aid cessation treatment. Objective: To independently assess the effects of nicotine dependence and stimulation of the nicotinic acetylcholine receptor on the ability to interpret valence information (reward sensitivity) and subsequently alter behavior as reward contingencies change (cognitive flexibility) in a probabilistic reversal learning task...
April 12, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28397160/implementation-of-a-tobacco-free-workplace-program-at-a-local-mental-health-authority
#3
Virmarie Correa-Fernández, William T Wilson, Deborah A Shedrick, Bryce Kyburz, Hannah L Samaha, Timothy Stacey, Teresa Williams, Cho Y Lam, Lorraine R Reitzel
Tobacco-free workplace policies that incorporate evidence-based practices can increase the reach and effectiveness of tobacco dependence treatment among underserved populations but may be underutilized due to limited knowledge about implementation processes. This paper describes the implementation of a comprehensive tobacco-free workplace program at a behavioral healthcare community center in Texas. The center participated in a tobacco-free workplace program implementation project that provided guidance and resources and allowed center autonomy in implementation...
April 10, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28395994/thujone-inhibits-the-function-of-%C3%AE-7-nicotinic-acetylcholine-receptors-and-impairs-nicotine-induced-memory-enhancement-in-one-trial-passive-avoidance-paradigm
#4
Ahmed Sultan, Keun-Hang Susan Yang, Dmitro Isaev, Eslam El Nebrisi, Nurulain Syed, Nadia Khan, Christopher F Howarth, Bassem Sadek, Murat Oz
Effects of thujone, a major ingredient of absinthe, wormwood oil and some herbal medicines, were tested on the function of α7 subunit of the human nicotinic acetylcholine (α7 nACh) receptor expressed in Xenopus oocytes using the two-electrode voltage-clamp technique. Thujone reversibly inhibited ACh (100μM)-induced currents with an IC50 value of 24.7μM. The effect of thujone was not dependent on the membrane potential and did not involve Ca(2+)-dependent Cl(-) channels expressed endogenously in oocytes...
April 7, 2017: Toxicology
https://www.readbyqxmd.com/read/28373127/rp5063-an-atypical-antipsychotic-drug-with-a-unique-pharmacologic-profile-improves-declarative-memory-and-psychosis-in-mouse-models-of-schizophrenia
#5
Lakshmi Rajagopal, Sunoh Kwon, Mei Huang, Eric Michael, Laxminarayan Bhat, Marc Cantillon, Herbert Y Meltzer
Various types of atypical antipsychotic drugs (AAPDs) modestly improve the cognitive impairment associated with schizophrenia (CIAS). RP5063 is an AAPD with a diverse and unique pharmacology, including partial agonism at dopamine (DA) D2, D3, D4, serotonin (5-HT)1A, and 5-HT2A receptors (Rs), full agonism at α4β2 nicotinic acetylcholine (ACh)R (nAChR), and antagonism at 5-HT2B, 5-HT6, and 5-HT7Rs. Most atypical APDs are 5-HT2A inverse agonists. The efficacy of RP5063 in mouse models of psychosis and episodic memory were studied...
March 31, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28339973/day-to-day-variability-in-self-reported-cigarettes-per-day
#6
John R Hughes, Saul Shiffman, Shelly Naud, Erica N Peters
Background and Aims: Nicotine addiction theory predicts small day to day variability in cigarettes/day (CPD) whereas social learning theory predicts large variability. A description of the variability in CPD over multiple days is not available. Methods: We conducted secondary analyses of two natural history studies with daily smokers - one of smokers not intending to quit, and one of smokers intending to quit sometime in the next 3 months. In the former, smokers recorded their smoking during the day by Ecological Momentary Assessment, using a palm-top computer...
March 4, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28321180/multiple-kinases-involved-in-the-nicotinic-modulation-of-gamma-oscillations-in-the-rat-hippocampal-ca3-area
#7
JianGang Wang, XiaoLong He, Fangli Guo, XiangLin Cheng, Yali Wang, XiaoFang Wang, ZhiWei Feng, Martin Vreugdenhil, ChengBiao Lu
Neuronal synchronization at gamma band frequency (20-80 Hz, γ oscillations) is closely associated with higher brain function, such as learning, memory and attention. Nicotinic acetylcholine receptors (nAChRs) are highly expressed in the hippocampus, and modulate hippocampal γ oscillations, but the intracellular mechanism underlying such modulation remains elusive. We explored multiple kinases by which nicotine can modulate γ oscillations induced by kainate in rat hippocampal area CA3 in vitro. We found that inhibitors of cyclic AMP dependent kinase (protein kinase A, PKA), protein kinase C (PKC), N-methyl-D-aspartate receptor (NMDA) receptors, Phosphoinositide 3-kinase (PI3K) and extracellular signal-related kinases (ERK), each individually could prevent the γ oscillation-enhancing effect of 1 μM nicotine, whereas none of them affected baseline γ oscillation strength...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28315274/role-of-%C3%AF-1-receptors-in-learning-and-memory-and-alzheimer-s-disease-type-dementia
#8
Tangui Maurice, Nino Goguadze
The present chapter will review the role of σ1 receptor in learning and memory and neuroprotection , against Alzheimer's type dementia. σ1 Receptor agonists have been tested in a variety of pharmacological and pathological models of learning impairments in rodents these last past 20 years. Their anti-amnesic effects have been explained by the wide-range modulatory role of σ1 receptors on Ca(2+) mobilizations, neurotransmitter responses, and particularly glutamate and acetylcholine systems, and neurotrophic factors...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28293176/muscarinic-receptors-are-responsible-for-the-cholinergic-modulation-of-projection-neurons-in-the-song-production-brain-nucleus-ra-of-zebra-finches
#9
Wei Meng, Songhua Wang, Lihua Yao, Nan Zhang, Dongfeng Li
Songbirds are a useful model for the study of learned vocal behavior in vertebrates. The robust nucleus of the arcopallium (RA) is a premotor nucleus in the vocal motor pathway. It receives excitatory synaptic inputs from the anterior forebrain pathway. RA also receives cholinergic inputs from the ventral paleostriatum of the basal forebrain. Our previous study showed that carbachol, a non-selective cholinergic receptor agonist, modulates the electrophysiology of RA projection neurons (PNs), indicating that cholinergic modulation of RA may play an important role in song production...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28270757/effectiveness-of-a-novel-qigong-meditative-movement-practice-for-impaired-health-in-flight-attendants-exposed-to-second-hand-cigarette-smoke
#10
Peter Payne, Steven Fiering, James C Leiter, David T Zava, Mardi A Crane-Godreau
This single-arm non-randomized pilot study explores an intervention to improve the health of flight attendants (FA) exposed to second-hand cigarette smoke prior to the smoking ban on commercial airlines. This group exhibits an unusual pattern of long-term pulmonary dysfunction. We report on Phase I of a two-phase clinical trial; the second Phase will be a randomized controlled trial testing digital delivery of the intervention. Subjects were recruited in the Northeastern US; testing and intervention were administered in 4 major cities...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28258047/mobile-phone-apps-for-smoking-cessation-quality-and-usability-among-smokers-with-psychosis
#11
Joelle C Ferron, Mary F Brunette, Pamela Geiger, Lisa A Marsch, Anna M Adachi-Mejia, Stephen J Bartels
BACKGROUND: Smoking is one of the top preventable causes of mortality in people with psychotic disorders such as schizophrenia. Cessation treatment improves abstinence outcomes, but access is a barrier. Mobile phone apps are one way to increase access to cessation treatment; however, whether they are usable by people with psychotic disorders, who often have special learning needs, is not known. OBJECTIVE: Researchers reviewed 100 randomly selected apps for smoking cessation to rate them based on US guidelines for nicotine addiction treatment and to categorize them based on app functions...
March 3, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28217868/an-anti-nicotinic-cognitive-challenge-model-using-mecamylamine-in-comparison-with-the-anti-muscarinic-cognitive-challenge-using-scopolamine
#12
A C Baakman, R Alvarez-Jimenez, R Rissmann, E S Klaassen, J Stevens, S C Goulooze, J Burger, E L Swart, J M A van Gerven, G J Groeneveld
INTRODUCTION: The muscarinic acetylcholine receptor antagonist scopolamine is often used for proof-of-pharmacology studies with pro-cognitive compounds. From a pharmacological point of view, it would seem more rational to use a nicotinic rather than a muscarinic anticholinergic challenge to prove pharmacology of a nicotinic acetylcholine receptor agonist. This study aims to characterize a nicotinic anticholinergic challenge model using mecamylamine and to compare it to the scopolamine model...
February 20, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28213446/acetylcholine-release-in-prefrontal-cortex-promotes-gamma-oscillations-and-theta-gamma-coupling-during-cue-detection
#13
William M Howe, Howard J Gritton, Nicholas A Lusk, Erik A Roberts, Vaughn L Hetrick, Joshua D Berke, Martin Sarter
The capacity for using external cues to guide behavior ("cue detection") constitutes an essential aspect of attention and goal-directed behavior. The cortical cholinergic input system, via phasic increases in prefrontal acetylcholine release, plays an essential role in attention by mediating such cue detection. However, the relationship between cholinergic signaling during cue detection and neural activity dynamics in prefrontal networks remains unclear. Here we combined subsecond measures of cholinergic signaling, neurophysiological recordings, and cholinergic receptor blockade to delineate the cholinergic contributions to prefrontal oscillations during cue detection in rats...
March 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28209560/from-the-experience-of-interactivity-and-entertainment-to-lower-intention-to-smoke-a-randomized-controlled-trial-and-path-analysis-of-a-web-based-smoking-prevention-program-for-adolescents
#14
Georges Elias Khalil, Hua Wang, Karen Sue Calabro, Natasha Mitra, Ross Shegog, Alexander V Prokhorov
BACKGROUND: Web-based programs for smoking prevention are being increasingly used with some success among adolescents. However, little is known about the mechanisms that link the experience of such programs to intended nicotine or tobacco control outcomes. OBJECTIVE: Based on the experiential learning theory and extended elaboration likelihood model, this study aimed to evaluate the impact of a Web-based intervention, A Smoking Prevention Interactive Experience (ASPIRE), on adolescents' intention to smoke, while considering the experience of interactivity and entertainment as predictors of reduced intention to smoke, under a transitional user experience model...
February 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28146250/effect-of-selective-inhibition-of-reactivated-nicotine-associated-memories-with-propranolol-on-nicotine-craving
#15
Yan-Xue Xue, Jia-Hui Deng, Ya-Yun Chen, Li-Bo Zhang, Ping Wu, Geng-Di Huang, Yi-Xiao Luo, Yan-Ping Bao, Yu-Mei Wang, Yavin Shaham, Jie Shi, Lin Lu
Importance: A relapse into nicotine addiction during abstinence often occurs after the reactivation of nicotine reward memories, either by acute exposure to nicotine (a smoking episode) or by smoking-associated conditioned stimuli (CS). Preclinical studies suggest that drug reward memories can undergo memory reconsolidation after being reactivated, during which they can be weakened or erased by pharmacological or behavioral manipulations. However, translational clinical studies using CS-induced memory retrieval-reconsolidation procedures to decrease drug craving reported inconsistent results...
March 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28146248/disruption-of-reward-processing-in-addiction-an-image-based-meta-analysis-of-functional-magnetic-resonance-imaging-studies
#16
Maartje Luijten, Arnt F Schellekens, Simone Kühn, Marise W J Machielse, Guillaume Sescousse
Importance: Disrupted reward processing, mainly driven by striatal dysfunction, is a key characteristic of addictive behaviors. However, functional magnetic resonance imaging (fMRI) studies have reported conflicting results, with both hypoactivations and hyperactivations during anticipation and outcome notification of monetary rewards in addiction. Objective: To determine the nature and direction of reward-processing disruptions during anticipation and outcome notification of monetary rewards in individuals with addiction using image-based meta-analyses of fMRI studies...
April 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28146243/effect-of-a-brief-memory-updating-intervention-on-smoking-behavior-a-randomized-clinical-trial
#17
Lisa J Germeroth, Matthew J Carpenter, Nathaniel L Baker, Brett Froeliger, Steven D LaRowe, Michael E Saladin
Importance: Recent research on addiction-related memory processes suggests that protracted extinction training following brief cue-elicited memory retrieval (ie, retrieval-extinction [R-E] training) can attenuate/eradicate the ability of cues to elicit learned behaviors. One study reported that cue-elicited craving among detoxified heroin addicts was substantially attenuated following R-E training and through 6-month follow-up. Objective: To build on these impressive findings by examining whether R-E training could attenuate smoking-related craving and behavior...
March 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28126511/efficacy-of-mindfulness-meditation-for-smoking-cessation-a-systematic-review-and-meta-analysis
#18
REVIEW
Margaret A Maglione, Alicia Ruelaz Maher, Brett Ewing, Benjamin Colaiaco, Sydne Newberry, Ryan Kandrack, Roberta M Shanman, Melony E Sorbero, Susanne Hempel
BACKGROUND: Smokers increasingly seek alternative interventions to assist in cessation or reduction efforts. Mindfulness meditation, which facilitates detached observation and paying attention to the present moment with openness, curiosity, and acceptance, has recently been studied as a smoking cessation intervention. AIMS: This review synthesizes randomized controlled trials (RCTs) of mindfulness meditation (MM) interventions for smoking cessation. METHODS: Five electronic databases were searched from inception to October 2016 to identify English-language RCTs evaluating the efficacy and safety of MM interventions for smoking cessation, reduction, or a decrease in nicotine cravings...
January 18, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28126277/weight-of-evidence-evaluation-of-a-network-of-adverse-outcome-pathways-linking-activation-of-the-nicotinic-acetylcholine-receptor-in-honey-bees-to-colony-death
#19
REVIEW
Carlie A LaLone, Daniel L Villeneuve, Judy Wu-Smart, Rebecca Y Milsk, Keith Sappington, Kristina V Garber, Justin Housenger, Gerald T Ankley
Ongoing honey bee (Apis mellifera) colony losses are of significant international concern because of the essential role these insects play in pollinating crops. Both chemical and non-chemical stressors have been implicated as possible contributors to colony failure; however, the potential role(s) of commonly-used neonicotinoid insecticides has emerged as particularly concerning. Neonicotinoids act on the nicotinic acetylcholine receptors (nAChRs) in the central nervous system to eliminate pest insects. However, mounting evidence indicates that neonicotinoids also may adversely affect beneficial pollinators, such as the honey bee, via impairments on learning and memory, and ultimately foraging success...
April 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28105289/development-of-4-heteroarylamino-1-azaspiro-oxazole-5-3-bicyclo-2-2-2-octanes-as-%C3%AE-7-nicotinic-receptor-agonists
#20
Matthew D Hill, Haiquan Fang, H Dalton King, Christiana I Iwuagwu, Ivar M McDonald, James Cook, F Christopher Zusi, Robert A Mate, Ronald J Knox, Debra Post-Munson, Amy Easton, Regina Miller, Kimberley Lentz, Wendy Clarke, Yulia Benitex, Nicholas Lodge, Robert Zaczek, Rex Denton, Daniel Morgan, Linda Bristow, John E Macor, Richard Olson
We describe the synthesis of quinuclidine-containing spiroimidates and their utility as α7 nicotinic acetylcholine receptor (nAChR) partial agonists. A convergent synthetic route allowed for rapid SAR investigation and provided a diverse set of fused 6,5-heteroaryl analogs. Two potent and selective α7 nAChR partial agonists, (1'S,3'R,4'S)-N-(7-bromopyrrolo[2,1-f][1,2,4]triazin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine (20) and (1'S,3'R,4'S)-N-(7-chloropyrrolo[2,1-f][1,2,4]triazin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2...
January 12, 2017: ACS Medicinal Chemistry Letters
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