keyword
MENU ▼
Read by QxMD icon Read
search

nicotine, learning

keyword
https://www.readbyqxmd.com/read/29667304/inhibition-of-alpha7-nicotinic-receptors-in-the-ventral-hippocampus-selectively-attenuates-reinstatement-of-morphine-conditioned-place-preference-and-associated-changes-in-ampa-receptor-binding
#1
Victoria L Wright, Polymnia Georgiou, Alexis Bailey, David J Heal, Christopher P Bailey, Susan Wonnacott
Recurrent relapse is a major problem in treating opiate addiction. Pavlovian conditioning plays a role in recurrent relapse whereby exposure to cues learned during drug intake can precipitate relapse to drug taking. α7 nicotinic acetylcholine receptors (nAChRs) have been implicated in attentional aspects of cognition and mechanisms of learning and memory. In this study we have investigated the role of α7 nAChRs in morphine-conditioned place preference (morphine-CPP). CPP provides a model of associative learning that is pertinent to associative aspects of drug dependence...
April 17, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29653137/hyperactivity-and-memory-learning-deficits-evoked-by-developmental-exposure-to-nicotine-and-or-ethanol-are-mitigated-by-camp-and-cgmp-signaling-cascades-activation
#2
Yael Abreu-Villaça, Anna C Carvalho-Graça, Gabriela Skinner, Bruna M Lotufo, Vitor H S Duarte-Pinheiro, Anderson Ribeiro-Carvalho, Alex C Manhães, Claudio C Filgueiras
Pregnant smoking women are frequently episodic drinkers. Here, we investigated whether ethanol exposure restricted to the brain growth spurt period when combined with chronic developmental exposure to nicotine aggravates memory/learning deficits and hyperactivity, and associated cAMP and cGMP signaling disruption. To further investigate the role of these signaling cascades, we verified whether vinpocetine (a phosphodiesterase inhibitor) ameliorates the neurochemical and behavioral outcomes. Swiss mice had free access to nicotine (NIC, 50 μg/ml) or water to drink during gestation and until the 8th postnatal day (PN8)...
April 10, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29563522/effects-of-the-novel-pesticide-flupyradifurone-sivanto-on-honeybee-taste-and-cognition
#3
Hannah Hesselbach, Ricarda Scheiner
Due to intensive agriculture honeybees are threatened by various pesticides. The use of one group of them, the neonicotinoids, was recently restricted by the European Union. These chemicals bind to the nicotinic acetylcholine receptor (nAchR) in the honeybee brain. Recently, Bayer AG released a new pesticide by the name of "Sivanto" against sucking insects. It is assumed to be harmless for honeybees, although its active ingredient, flupyradifurone, binds nAchR similar to the neonicotinoids. We investigated if this pesticide affects the taste for sugar and cognitive performance in honeybee foragers...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29530492/agmatine-inhibits-nicotine-withdrawal-induced-cognitive-deficits-in-inhibitory-avoidance-task-in-rats-contribution-of-%C3%AE-2-adrenoceptors
#4
Nandkishor R Kotagale, Mir Touseef Ali, Chandrabhan T Chopde, Milind J Umekar, Brijesh G Taksande
Nicotine abstinence following chronic exposure is associated with impairments in memory and variety of cognitive functions. Daily nicotine (2 mg/kg, sc, four times daily) administration for 14 days and its abrupt withdrawal significantly impaired avoidance learning in inhibitory avoidance task as indicated by a significant decrease in the step through latency. Animals injected with agmatine (10-40 μg/rat, icv) from day 7 to 14 before the first daily dose of nicotine (2 mg/kg, sc) showed increased step through latencies during retrieval test...
April 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29519998/hcn2-rescues-brain-defects-by-enforcing-endogenous-voltage-pre-patterns
#5
Vaibhav P Pai, Alexis Pietak, Valerie Willocq, Bin Ye, Nian-Qing Shi, Michael Levin
Endogenous bioelectrical signaling coordinates cell behaviors toward correct anatomical outcomes. Lack of a model explaining spatialized dynamics of bioelectric states has hindered the understanding of the etiology of some birth defects and the development of predictive interventions. Nicotine, a known neuroteratogen, induces serious defects in brain patterning and learning. Our bio-realistic computational model explains nicotine's effects via the disruption of endogenous bioelectrical gradients and predicts that exogenous HCN2 ion channels would restore the endogenous bioelectric prepatterns necessary for brain patterning...
March 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29518543/nicotine-exposure-leads-to-deficits-in-differential-cued-fear-conditioning-in-mice-and-humans-a-potential-role-of-the-anterior-cingulate-cortex
#6
Munir Gunes Kutlu, Marie-France Marin, Jessica M Tumolo, Navneet Kaur, Michael B VanElzakker, Lisa M Shin, Thomas J Gould
Stress and anxiety disorders such as posttraumatic stress disorder (PTSD) are characterized by disrupted safety learning. Tobacco smoking has been strongly implicated in stress and anxiety disorder symptomatology, both as a contributing factor and as a vulnerability factor. Rodent studies from our lab have recently shown that acute and chronic nicotine exposure disrupts safety learning. However, it is unknown if these effects of nicotine translate to humans. The present studies addressed this gap by administering a translational differential cued fear conditioning paradigm to both mice and humans...
March 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29516284/stimulation-of-ace2-ang-1-7-mas-axis-by-diminazene-ameliorates-alzheimer-s-disease-in-the-d-galactose-ovariectomized-rat-model-role-of-pi3k-akt-pathway
#7
Ahmed S Kamel, Noha F Abdelkader, Sahar S Abd El-Rahman, Marwan Emara, Hala F Zaki, Mahmoud M Khattab
Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1 (ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in Alzheimer's disease (AD). Moreover, activation of AT1 impairs the survival pathway phosphoinositide 3-kinase/protein kinase B (PI3K/Akt). Interestingly, the coupling between ACE2/Ang(1-7)/Mas receptor (MasR) axis and PI3K/Akt activation opposes AT1-induced apoptosis. However, the effect of in vivo stimulation of MasR against AD and its correlation to PI3K/Akt is not yet elucidated...
March 7, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29501507/early-social-experience-alters-transcriptomic-responses-to-species-specific-song-stimuli-in-female-songbirds
#8
Matthew I M Louder, Mark E Hauber, Christopher N Balakrishnan
Amongst an array of stimuli from countless species, animals must recognize salient signals, including those of their own species. In songbirds, behavioral tests have demonstrated that preferences for conspecific male songs are determined by both preexisting biases and social experience with a male 'tutor' during the sensitive period for learning. Although immediate early gene expression (e.g. ZENK) and electrophysiological experiments generally find greater neural responses for conspecific songs, it remains unclear whether distinct mechanisms, such as sensory gating, are engaged to filter out irrelevant heterospecific songs...
March 1, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29493350/tyrosine-receptor-kinase-b-receptor-activation-reverses-the-impairing-effects-of-acute-nicotine-on-contextual-fear-extinction
#9
Munir Gunes Kutlu, Robert D Cole, David A Connor, Brendan Natwora, Thomas J Gould
Anxiety and stress disorders have been linked to deficits in fear extinction. Our laboratory and others have demonstrated that acute nicotine impairs contextual fear extinction, suggesting that nicotine exposure may have negative effects on anxiety and stress disorder symptomatology. However, the neurobiological mechanisms underlying the acute nicotine-induced impairment of contextual fear extinction are unknown. Therefore, based on the previous studies showing that brain-derived neurotrophic factor is central for fear extinction learning and acute nicotine dysregulates brain-derived neurotrophic factor signaling, we hypothesized that the nicotine-induced impairment of contextual fear extinction may involve changes in tyrosine receptor kinase B signaling...
February 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29490380/-attention-deficit-hyperactivity-disorder-adhd-in-adult-psychiatry-data-on-12-month-prevalence-risk-factors-and-comorbidity
#10
Matthias Miesch, Arno Deister
AIMS AND METHODS: To examine the 12-month prevalence, risk factors, and comorbidity of ADHD in a collective of adult psychiatric patients admitted to an open general ward in a psychiatric hospital in Schleswig-Holstein (Germany) over a period of one year (n = 166). RESULTS: The 12 months prevalence of ADHD was 59.0 % (severe symptomatology: 33.1 %), high rates of comorbid disorders (92.9 % depression, 5.1 % bipolar disorder, 28.6 % anxiety disorder, 30...
February 28, 2018: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29477596/nicotine-facilitates-synaptic-depression-in-layer-v-pyramidal-neurons-of-the-mouse-insular-cortex
#11
Hiroki Toyoda
The insular cortex is known to play a pivotal role in addiction to nicotine. Long-term depression (LTD) in the central nervous system is a major form of synaptic plasticity which is involved in learning and memory and in various pathological conditions such as nicotine addiction. Until now, effects of nicotine on LTD were mainly examined in the hippocampus and striatum, and there is no report showing the effects of nicotine on LTD in the insular cortex. In the present study, I show for the first time that nicotine facilitates LTD which is induced by combination of presynaptic stimulation with postsynaptic depolarization (paired training) in layer 5 pyramidal neurons of the mouse insular cortex using whole-cell patch-clamp recordings...
February 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29459050/n-methyl-d-aspartate-type-glutamate-receptor-modulators-and-related-medications-for-the-enhancement-of-auditory-system-plasticity-in-schizophrenia
#12
Joshua T Kantrowitz
Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on early sensory (auditory and visual) information processing. Auditory mismatch negativity (MMN) can be both a target engagement biomarker for the NMDAR and a proxy measure of neurophysiological plasticity. This review covers the evidence for using NMDAR modulator and related compounds for enhancement of cognition, with a particular focus on early auditory processing/plasticity...
February 17, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29456645/influence-of-exposure-to-nicotine-during-pregnancy-on-the-learning-and-memory-for-adult-offspring
#13
Xing-Dui Ma, Bei-Ping Li, Yuan Han, Yun-Ping Tian, Liang Wu, Hang Wang
We aimed to investigate the indirect influence of exposure to nicotine during pregnancy on the learning and memory of adult offspring mice. Thirty pregnant C57 mice were randomly divided into either the control group (CON) or the nicotine group (NIC), with 15 mice each. The CON group was given access to drug-free water, and the NIC group was given 60 g/ml nicotine in drinking water. Sixteen adult mice were randomly selected from the 8 litters for Morris water maze test. The level of products of related factors in the hippocampus of mice in the NIC and the CON groups were compared using the1 H-MRS method...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29423839/molecular-neuronal-and-behavioral-effects-of-ethanol-and-nicotine-interactions
#14
Paul M Klenowski, Andrew R Tapper
Ethanol and nicotine can modulate the activity of several neurotransmitter systems and signalling pathways. Interactions between ethanol and nicotine can also occur via common molecular targets including nicotinic acetylcholine receptors (nAChRs). These effects can induce molecular and synaptic adaptations that over time, are consolidated in brain circuits that reinforce drug-seeking behavior, contribute to the development of withdrawal symptoms during abstinence and increase the susceptibility to relapse. This chapter will discuss the acute and chronic effects of ethanol and nicotine within the mesolimbic reward pathway and brain circuits involved in learning, memory, and withdrawal...
February 9, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29421347/the-emerging-marijuana-retail-environment-key-lessons-learned-from-tobacco-and-alcohol-retail-research
#15
REVIEW
Carla J Berg, Lisa Henriksen, Patricia A Cavazos-Rehg, Regine Haardoerfer, Bridget Freisthler
The emerging retail market for recreational marijuana use warrants research and surveillance as such markets are established in more US states. This research can be informed by the existing literature regarding tobacco and alcohol, which highlights the impact of spatial access to tobacco and alcohol retailers and exposure to tobacco and alcohol marketing on smoking and drinking among youth and young adults. Prior research indicates that tobacco and alcohol retailers, as well as medical marijuana dispensaries, are disproportionately located in neighborhoods characterized by socioeconomic disadvantage and by higher proportions of racial/ethnic minorities and young adults...
February 1, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29409736/biosignature-discovery-for-substance-use-disorders-using-statistical-learning
#16
REVIEW
James W Baurley, Christopher S McMahan, Carolyn M Ervin, Bens Pardamean, Andrew W Bergen
There are limited biomarkers for substance use disorders (SUDs). Traditional statistical approaches are identifying simple biomarkers in large samples, but clinical use cases are still being established. High-throughput clinical, imaging, and 'omic' technologies are generating data from SUD studies and may lead to more sophisticated and clinically useful models. However, analytic strategies suited for high-dimensional data are not regularly used. We review strategies for identifying biomarkers and biosignatures from high-dimensional data types...
February 3, 2018: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29390543/the-risk-of-missed-abortion-associated-with-the-levels-of-tobacco-heavy-metals-and-phthalate-in-hair-of-pregnant-woman-a-case-control-study-in-chinese-women
#17
Ranran Zhao, Yuelian Wu, Fangfang Zhao, Yingnan Lv, Damin Huang, Jinlian Wei, Chong Ruan, Mingli Huang, Jinghuan Deng, Dongping Huang, Xiaoqiang Qiu
To assess the association between exposure to the tobacco, heavy metals and phthalate on early pregnancy and missed abortion.42 women with missed abortion and 57 matched controls (women with normal pregnancies) were recruited between March and May 2012, from the Department of Gynecology and Obstetrics, First Affiliated Hospital of Guangxi Medical University and the People Hospital of Guangxi Zhuang Autonomous Region. The questionnaire survey was carried on to learn about the basic conditions, as well as smoking history of all participants...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384449/similar-nicotinic-excitability-responses-across-the-developing-hippocampal-formation-are-regulated-by-small-conductance-calcium-activated-potassium-channels
#18
Beryl Y T Chung, Craig D C Bailey
The hippocampal formation forms a cognitive circuit that is critical for learning and memory. Cholinergic input to nicotinic acetylcholine receptors plays an important role in the normal development of principal neurons within the hippocampal formation. However, the ability of nicotinic receptors to stimulate principal neurons across all regions of the developing hippocampal formation has not been determined. We show here that heteromeric nicotinic receptors mediate direct inward current and depolarization responses in principal neurons across the hippocampal formation of the young postnatal mouse...
January 31, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29383396/differential-effects-of-%C3%AE-4%C3%AE-2-nicotinic-receptor-antagonists-and-partial-agonists-on-contextual-fear-extinction-in-male-c57bl-6-mice
#19
Munir Gunes Kutlu, Jessica M Tumolo, Courtney Cann, Thomas J Gould
RATIONALE: Numerous studies have attributed the psychopathology of post-traumatic stress disorder (PTSD) to maladaptive behavioral responses such as an inability to extinguish fear. While exposure therapies are mostly effective in treating these disorders by enhancing extinction learning, relapse of PTSD symptoms is common. Although several studies indicated a role for cholinergic transmission and nicotinic acetylcholine receptors (nAChRs) in anxiety and stress disorder symptomatology, very little is known about the specific contribution of nAChRs to fear extinction OBJECTIVES: In the present study, we examined the effects of inhibition and desensitization of α4β2 nAChRs via a full antagonist (Dihydro-beta-erythroidine (DhβE)) and two α4β2 nAChR partial-agonists (varenicline and sazetidine-A) on contextual fear extinction, locomotor activity, and spontaneous recovery of contextual fear in mice...
January 30, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29379089/the-alpha7-nicotinic-receptor-contributes-to-gp120-induced-neurotoxicity-implications-in-hiv-associated-neurocognitive-disorders
#20
Coral M Capó-Vélez, Bryan Morales-Vargas, Aurian García-González, José G Grajales-Reyes, Manuel Delgado-Vélez, Bismark Madera, Carlos A Báez-Pagán, Orestes Quesada, José A Lasalde-Dominicci
Currently, there are no specific therapies to treat HIV-1 associated neurocognitive disorders (HAND). The HIV-1 envelope, gp120, induces neuropathological changes similar to those in HAND patients; furthermore, it triggers an upregulation of the α7-nicotinic acetylcholine receptor (α7-nAChR), facilitating intracellular calcium overload and neuronal cell death. Using a gp120IIIB-transgenic mouse (gp120-tgm) model, we demonstrate that α7-nAChRs are upregulated on striatal neurons. Activation of α7-nAChRs leads to an increase in both intracellular calcium and percentage of apoptotic cells, which can be abrogated by antagonizing the receptor, suggesting a role for α7-nAChRs in gp120-induced neurotoxicity...
January 29, 2018: Scientific Reports
keyword
keyword
99551
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"