keyword
MENU ▼
Read by QxMD icon Read
search

State dependent model

keyword
https://www.readbyqxmd.com/read/28734958/the-relative-importance-of-water-temperature-and-residence-time-in-predicting-cyanobacteria-abundance-in-regulated-rivers
#1
YoonKyung Cha, Kyung Hwa Cho, Hyuk Lee, Taegu Kang, Joon Ha Kim
Despite a growing awareness of the problems associated with cyanobacterial blooms in rivers, and particularly in regulated rivers, the drivers of bloom formation and abundance in rivers are not well understood. We developed a Bayesian hierarchical model to assess the relative importance of predictors of summer cyanobacteria abundance, and to test whether the relative importance of each predictor varies by site, using monitoring data from 16 sites in the four major rivers of South Korea. The results suggested that temperature and residence time, but not nutrient levels, are important predictors of summer cyanobacteria abundance in rivers...
July 18, 2017: Water Research
https://www.readbyqxmd.com/read/28734301/communication-influence-of-external-static-and-alternating-electric-fields-on-water-from-long-time-non-equilibrium-ab-initio-molecular-dynamics
#2
Zdenek Futera, Niall J English
The response of water to externally applied electric fields is of central relevance in the modern world, where many extraneous electric fields are ubiquitous. Historically, the application of external fields in non-equilibrium molecular dynamics has been restricted, by and large, to relatively inexpensive, more or less sophisticated, empirical models. Here, we report long-time non-equilibrium ab initio molecular dynamics in both static and oscillating (time-dependent) external electric fields, therefore opening up a new vista in rigorous studies of electric-field effects on dynamical systems with the full arsenal of electronic-structure methods...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734073/differential-calcium-sensitivity-in-nav-1-5-mixed-syndrome-mutants
#3
Mena Abdelsayed, Alban-Elouen Baruteau, Karen Gibbs, Shubhayan Sanatani, Andrew D Krahn, Vincent Probst, Peter C Ruben
INTRODUCTION: Inherited arrhythmias may arise from mutations in the SCN5a gene, which encodes the cardiac voltage-gated sodium channel, NaV 1.5. Mutants in NaV 1.5 result in Brugada Syndrome (BrS1), Long-QT Syndrome (LQT3), or mixed syndromes (an overlap of BrS1/LQT3). Exercise is a potential arrhythmogenic trigger in mixed syndromes. We sought to determine the effects of elevated cytosolic calcium, common during exercise, in mixed syndrome NaV 1.5 mutants. METHODS: We used whole-cell patch-clamp to assess the biophysical properties of NaV 1...
July 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28732395/microalgae-bacteria-models-evolution-from-microalgae-steady-state-to-integrated-microalgae-bacteria-wastewater-treatment-models-a-comparative-review
#4
REVIEW
Alessandro Solimeno, Joan García
The search for environmentally neutral alternative fuels had revived the interest for microalgae-bacteria wastewater treatment systems. The potential achieving of bioproducts from microalgae biomass has also greatly contributed. The reactions that occur in these systems are complex, and the degree of scientific knowledge is still scarce compared to that of conventional bacteria wastewater treatments. Mathematical models offer a great opportunity to study the simultaneous effect of the multiple factors affecting microalgae and bacteria, thus allowing for the prediction of final biomass production, and contributing to the system design optimization in terms of operation and control...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732236/neighborhood-ses-is-particularly-important-to-the-cardiovascular-health-of-low-ses-individuals
#5
Jennifer Morozink Boylan, Stephanie A Robert
RATIONALE: Health disparities defined by neighborhood socioeconomic status (SES) are well established; it is less well understood whether neighborhood SES is differentially associated with health depending on one's own SES. OBJECTIVE: The double jeopardy hypothesis, collective resources model, fundamental cause theory, and relative deprivation hypothesis support differential patterns of association between neighborhood and individual SES with health. The first three models suggest that higher neighborhood SES predicts health more strongly among lower, as compared to higher, SES individuals...
July 8, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28731730/uhlmann-connection-in-fermionic-systems-undergoing-phase-transitions
#6
Bruno Mera, Chrysoula Vlachou, Nikola Paunković, Vítor R Vieira
We study the behavior of the Uhlmann connection in systems of fermions undergoing phase transitions. In particular, we analyze some of the paradigmatic cases of topological insulators and superconductors in one dimension, as well as the BCS theory of superconductivity in three dimensions. We show that the Uhlmann connection signals phase transitions in which the eigenbasis of the state of the system changes. Moreover, using the established fidelity approach and the study of the edge states, we show the absence of thermally driven phase transitions in the case of topological insulators and superconductors...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28729926/coherence-of-bold-signal-and-electrical-activity-in-the-human-brain-during-deep-sevoflurane-anesthesia
#7
Daniel Golkowski, Andreas Ranft, Tobias Kiel, Valentin Riedl, Philipp Kohl, Guido Rohrer, Joachim Pientka, Sebastian Berger, Christine Preibisch, Claus Zimmer, George A Mashour, Gerhard Schneider, Eberhard F Kochs, Rüdiger Ilg, Denis Jordan
INTRODUCTION: Changes in neural activity induce changes in functional magnetic resonance (fMRI) blood oxygenation level dependent (BOLD) signal. Commonly, increases in BOLD signal are ascribed to cellular excitation. OBJECTIVE: The relationship between electrical activity and BOLD signal in the human brain was probed on the basis of burst suppression EEG. This condition includes two distinct states of high and low electrical activity. METHODS: Resting-state simultaneous EEG and BOLD measurements were acquired during deep sevoflurane anesthesia with burst suppression EEG in nineteen healthy volunteers...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729891/vibrational-excitation-of-h2-scattering-from-cu-111-effects-of-surface-temperature-and-of-allowing-energy-exchange-with-the-surface
#8
Geert-Jan Kroes, J I Juaristi, M Alducin
In scattering of H2 from Cu(111), vibrational excitation has so far defied an accurate theoretical description. To expose the causes of the large discrepancies with experiment, we investigate how the feature due to vibrational excitation (the "gain peak") in the simulated time-of-flight spectrum of (v = 1, j = 3) H2 scattering from Cu(111) depends on the surface temperature (Ts) and the possibility of energy exchange with surface phonons and electron-hole pairs (ehp's). Quasi-classical dynamics calculations are performed on the basis of accurate semiempirical density functionals for the interaction with H2 + Cu(111)...
June 29, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28729702/structure-of-general-population-antibody-titer-distributions-to-influenza-a-virus
#9
Nguyen Thi Duy Nhat, Stacy Todd, Erwin de Bruin, Tran Thi Nhu Thao, Nguyen Ha Thao Vy, Tran Minh Quan, Dao Nguyen Vinh, Janko van Beek, Pham Hong Anh, Ha Minh Lam, Nguyen Thanh Hung, Nguyen Thi Le Thanh, Huynh Le Anh Huy, Vo Thi Hong Ha, Stephen Baker, Guy E Thwaites, Nguyen Thi Nam Lien, Tran Thi Kim Hong, Jeremy Farrar, Cameron P Simmons, Nguyen Van Vinh Chau, Marion Koopmans, Maciej F Boni
Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729424/molecular-determinants-of-acidic-ph-dependent-transport-of-human-equilibrative-nucleoside-transporter-3
#10
Md Fazlur Rahman, Candice Askwith, Rajgopal Govindarajan
Equilibrative nucleoside transporters (ENTs) translocate hydrophilic nucleosides across cellular membranes and are essential for salvage nucleotide synthesis and purinergic signaling. Unlike the prototypic human ENT members hENT1 and hENT2, which mediate plasma membrane nucleoside transport at pH 7.4, hENT3 is an acidic pH-activated lysosomal transporter partially localized to mitochondria. Recent studies demonstrate that hENT3 is indispensable for lysosomal homeostasis, and that mutations in hENT3 can result in a spectrum of lysosomal storage-like disorders...
July 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28729405/super-enhancer-analysis-defines-novel-epigenomic-subtypes-of-non-apl-aml-including-an-rar%C3%AE-dependency-targetable-by-sy-1425-a-potent-and-selective-rar%C3%AE-agonist
#11
Michael R McKeown, M Ryan Corces, Matthew L Eaton, Chris Fiore, Emily Lee, Jeremy T Lopez, Mei Wei Chen, Darren Smith, Steven M Chan, Julie L Koenig, Kathryn Austgen, Matt G Guenther, David A Orlando, Jakob Lovén, Christian C Fritz, Ravindra Majeti
We characterized the enhancer landscape of 66 AML patients, identifying 6 novel subgroups and their associated regulatory loci. These subgroups are defined by their super-enhancer (SE) maps, orthogonal to somatic mutations, and are associated with distinct leukemic cell states. Examination of transcriptional drivers for these epigenomic subtypes uncovers a subset of patients with a particularly strong super-enhancer at the retinoic acid receptor alpha (RARA) gene locus. Presence of a RARA SE and concomitant high levels of RARA mRNA predisposes cell lines and ex vivo models to exquisite sensitivity to a selective agonist of RARα, SY-1425 (tamibarotene)...
July 20, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28729163/computational-analysis-of-interactions-of-oxidative-stress-and-tetrahydrobiopterin-reveals-instability-in-enos-coupling
#12
Sheetal Joshi, Saptarshi Kar, Mahendra Kavdia
In cardiovascular and neurovascular diseases, an increase in oxidative stress and endothelial dysfunction has been reported. There is a reduction in tetrahydrobiopterin (BH4), which is a cofactor for the endothelial nitric oxide synthase (eNOS), resulting in eNOS uncoupling. Studies of the enhancement of BH4 availability have reported mixed results for improvement in endothelial dysfunction. Our understanding of the complex interactions of eNOS uncoupling, oxidative stress and BH4 availability is not complete and a quantitative understanding of these interactions is required...
July 17, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28729016/learning-based-structurally-guided-construction-of-resting-state-functional-correlation-tensors
#13
Lichi Zhang, Han Zhang, Xiaobo Chen, Qian Wang, Pew-Thian Yap, Dinggang Shen
Functional magnetic resonance imaging (fMRI) measures changes in blood-oxygenation-level-dependent (BOLD) signals to detect brain activities. It has been recently reported that the spatial correlation patterns of resting-state BOLD signals in the white matter (WM) also give WM information often measured by diffusion tensor imaging (DTI). These correlation patterns can be captured using functional correlation tensor (FCT), which is analogous to the diffusion tensor (DT) obtained from DTI. In this paper, we propose a noise-robust FCT method aiming at further improving its quality, and making it eligible for further neuroscience study...
July 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28727451/regular-fluorescence-of-4-fluoro-n-n-dimethylaniline-fdma-no-charge-transfer-and-no-twisting
#14
Mercedes Vanessa Bohnwagner, Andreas Dreuw
Recently, two contradicting experimental investigations by Zachariasse et al. (J. Phys. Chem. A, 2017, 121, 1223) and Fujiwara et al. (Chem. Phys. Lett., 2013, 586, 70) have been published on the fluorescence behavior of FDMA. Motivated by the discrepancies between these studies we have examined the deactivation pathways of photoexcited FDMA using high-level quantum chemical methods like time-dependent density functional theory (TDDFT), coupled cluster (CC2) and algebraic-diagrammatic construction scheme (ADC(2), ADC(3)) simulating solvation using continuum solvation models...
July 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28726909/lysine-based-amino-functionalized-lipids-for-gene-transfection-the-protonation-state-in-monolayers-at-the-air-liquid-interface
#15
Stephanie Tassler, Christian Wölk, Christopher Janich, Bodo Dobner, Gerald Brezesinski
Cationic lipids are considered as non-viral carriers for genetic material used in gene therapy. They have no carcinogenic potential and cause low immune response compared to existing viral systems. The protonation degree of these cationic lipids is a crucial parameter for the binding behavior of polynucleotides (e.g., DNA). Newly synthesized peptide-mimic lysine-based amino-functionalized lipids have been investigated in 2D models as monolayers at the air-liquid interface. Standard surface pressure - area isotherms have been measured to prove the layer stability...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726895/a-fluorescence-electrochemical-study-of-carbon-nanodots-cnds-in-bio-and-photoelectronic-applications-and-energy-gap-investigation
#16
Zheng Zeng, Wendi Zhang, Durga M Arvapalli, Brian Bloom, Alex Sheardy, Taylor Mabe, Yiyang Liu, Zuowei Ji, Harish Chevva, David H Waldeck, Jianjun Wei
Carbon nanodots (CNDs) have attracted great attention due to their superior solubility, biocompatibility, tunable photoluminescence, and opto-electronic properties. This work describes a new fluorescence-based spectroelectrochemistry approach to simultaneously study the photoluminescence and wavelength dependent photocurrent of microwave synthesized CNDs. The fluorescence of CNDs shows selective quenching upon a reversible redox couple, ferricyanide/ferrocyanide, reaction during cyclic voltammetry. The CND modified gold slide electrode demonstrates wavelength dependent photocurrent generation during the fluorescence-electrochemical study, suggesting the potential application of CNDs in photoelectronics...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726643/reconstructed-ancestral-enzymes-reveal-that-negative-selection-drove-the-evolution-of-substrate-specificity-in-adp-dependent-kinases
#17
Víctor Castro-Fernandez, Alejandra Herrera-Morande, Ricardo Zamora, Felipe Merino, Felipe Gonzalez-Ordenes, Felipe Padilla-Salinas, Humberto M Pereira, Jose Brandão-Neto, Richard C Garratt, Victoria Guixe
One central goal in molecular evolution is to pinpoint the mechanisms and evolutionary forces that cause an enzyme to change its substrate specificity; however, these processes remain largely unexplored. Using the glycolytic ADP-dependent kinases of archaea, including the orders Thermococcales, Methanosarcinales, and Methanococcales, as a model and employing an approach involving paleoenzymology, evolutionary statistics, and protein structural analysis, we could track changes in substrate specificity during ADP-dependent kinase evolution along with the structural determinants of these changes...
July 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28726128/on-the-response-of-the-baltic-proper-to-changes-of-the-total-phosphorus-supply
#18
Anders Stigebrandt
Using a time-dependent phosphorus (P) budget model for the Baltic proper, describing sources and sinks at the external borders of the water column, one may compute the e-folding time T of the adjustment of the winter surface water P concentration c 1 to abruptly changed total P supply. The restoration time TR = 3T is introduced as a practical measure of the time it takes to achieve 95% of the change of c 1 towards the final, equilibrium, state c 1e. The P budget model, including an internal source emanating from deep anoxic bottoms, also shows that c 1e is proportional to the total P supply to the water column...
July 19, 2017: Ambio
https://www.readbyqxmd.com/read/28725998/membrane-phase-transition-during-heating-and-cooling-molecular-insight-into-reversible-melting
#19
Liping Sun, Rainer A Böckmann
With increasing temperature, lipid bilayers undergo a gel-fluid phase transition, which plays an essential role in many physiological phenomena. In the present work, this first-order phase transition was investigated for variable heating and cooling rates for a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer by means of atomistic molecular dynamics simulations. Alternative methods to track the melting temperature [Formula: see text] are compared. The resulting [Formula: see text] is shown to be independent of the scan rate for small heating rates (0...
July 19, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28724784/representing-delayed-force-feedback-as-a-combination-of-current-and-delayed-states
#20
Guy Avraham, Firas Mawase, Amir Karniel, Lior Shmuelof, Opher Donchin, Ferdinando A Mussa-Ivaldi, Ilana Nisky
To adapt to deterministic force perturbations that depend on the current state of the hand, internal representations are formed to capture the relationships between forces experienced and motion. However, information from multiple modalities travels at different rates, resulting in intermodal delays that require compensation for these internal representations to develop. To understand how these delays are represented by the brain, we presented participants with delayed velocity-dependent force fields; i.e., forces that depend on hand velocity either 70 or 100 ms beforehand...
July 19, 2017: Journal of Neurophysiology
keyword
keyword
99530
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"