keyword
MENU ▼
Read by QxMD icon Read
search

State dependent model

keyword
https://www.readbyqxmd.com/read/28445697/influence-of-maturation-on-in-vivo-tissue-to-plasma-partition-coefficients-for-cis-and-trans-permethrin
#1
Manoj Amaraneni, Jing Pang, James V Bruckner, Srinivasa Muralidhara, Tanzir B Mortuza, Darren Gullick, Shirin Hooshfar, Catherine A White, Brian S Cummings
Permethrin, the most widely used household insecticide in the U.S., is marketed as a mixture of its cis (CIS) and trans (TRANS) isomers. The major objective of this investigation was to develop and utilize a reliable approach to determine in vivo partition coefficients (PCs) for CIS and TRANS in immature and adult Sprague-Dawley rats. Adult, postnatal day (PND) 21 and PND 15 rats were infused with environmentally relevant concentrations of CIS or TRANS via a s.c. osmotic pump for 48 or 72 h. The adult and PND 21 rats also received an oral loading dose...
April 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28445537/predicting-epidemic-evolution-on-contact-networks-from-partial-observations
#2
Jacopo Bindi, Alfredo Braunstein, Luca Dall'Asta
The massive employment of computational models in network epidemiology calls for the development of improved inference methods for epidemic forecast. For simple compartment models, such as the Susceptible-Infected-Recovered model, Belief Propagation was proved to be a reliable and efficient method to identify the origin of an observed epidemics. Here we show that the same method can be applied to predict the future evolution of an epidemic outbreak from partial observations at the early stage of the dynamics...
2017: PloS One
https://www.readbyqxmd.com/read/28444057/determinant-factors-of-knowledge-attitudes-and-practices-regarding-std-aids-and-viral-hepatitis-among-youths-aged-18-to-29-years-in-brazil
#3
Miguel Barbosa Fontes, Rodrigo Campos Crivelaro, Alice Margini Scartezini, David Duarte Lima, Alexandre de Araújo Garcia, Rafael Tsuyoshi Fujioka
The scope of this study was to evaluate the vulnerability of Brazilian youths to STDs/HIV&AIDS and Viral Hepatitis. Interviews were conducted with 1,208 youths aged 18 to 29 in 15 states and the Federal District. The regional and national adjusted margin of error of the research was 2.8%. The study was approved by the School of Medicine of Brasilia University with support from PAHO and the Ministry of Health. A scale with 35 questions (knowledge, attitudes and practices) was the main dependent variable. Adjusted linear regression models identified the demographic and social determinant factors that explain scale variations...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444046/health-care-networks-implementation-and-regional-governance-challenges-in-the-legal-amazon-region-an-analysis-of-the-qualisus-rede-project
#4
Angela Oliveira Casanova, Marly Marques Cruz, Ligia Giovanella, Glaydes Dos Reis Alves, Gisela Cordeiro Pereira Cardoso
This paper aims to analyze the potential, limits and challenges of regional governance in the implementation process of health care networks in three Brazilian regions: Alto Solimões (Amazonas), Belém (Pará) and an interstate region comprising Tocantins, Pará and Maranhão states (Topama). The study is based on the evaluation study on the implementation of the Quality Health Care Network Development and Improvement Project (QualiSUS-Rede). This is a qualitative multiple case study with the analysis of official documents and use of semi-structured interviews with key stakeholders conducted from July to December 2014...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28443916/a-kinetic-model-of-water-adsorption-clustering-and-dissociation-on-the-fe3s4-001-surface
#5
Alberto Roldan, Nora H de Leeuw
The interaction of water with catalyst surfaces is a common process which requires investigation. Here, we have employed density functional theory calculations to investigate the adsorption of up to ten water molecules on the {001} surface of greigite (Fe3S4), which owing to its redox properties, is of increasing interest as a catalyst, e.g. in electro-catalysis. We have systematically analyzed and characterized the modes of water adsorption on the surface, where we have considered both molecular and dissociative adsorption processes...
April 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28443477/psychotherapist-trainees-professional-self-doubt-and-negative-personal-reaction-changes-during-cognitive-behavioral-therapy-and-association-with-patient-progress
#6
Patrizia Odyniec, Thomas Probst, Jürgen Margraf, Ulrike Willutzki
OBJECTIVE: This study examined psychotherapist trainees' experiences of "professional self-doubt" (PSD) and "negative personal reaction" (NPR) during cognitive behavioral therapy (CBT) and their associations with patients' symptoms and interpersonal problems. METHOD: Forty therapists treating 621 patients were analyzed. Patients' symptoms and interpersonal problems were collected repeatedly during therapy. Data about patients' interpersonal problems were available only for 106 patients and 18 therapists...
April 26, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28442890/justification-of-disintegration-testing-beyond-current-fda-criteria-using-in-vitro-and-in-silico-models
#7
Lukas Uebbing, Lukas Klumpp, Gregory K Webster, Raimar Löbenberg
Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration testing, the mentioned criteria are not globally accepted. This study provides scientific justification for using disintegration testing rather than dissolution testing as a quality control method for certain immediate release (IR) formulations...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28442770/design-principles-governing-chemomechanical-coupling-of-kinesin
#8
Tomonari Sumi
A systematic chemomechanical network model for the molecular motor kinesin is presented in this report. The network model is based on the nucleotide-dependent binding affinity of the heads to an microtubule (MT) and the asymmetries and similarities between the chemical transitions caused by the intramolecular strain between the front and rear heads. The network model allows for multiple chemomechanical cycles and takes into account all possible mechanical transitions between states in which one head is strongly bound and the other head is weakly bound to an MT...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442731/glag-theory-for-superconducting-property-variations-with-a15-composition-in-nb3sn-wires
#9
Yingxu Li, Yuanwen Gao
We present a model for the variation of the upper critical field H c2 with Sn content in A15-type Nb-Sn wires, within the Ginzburg-Landau-Abrikosov-Gor'kov (GLAG) theory frame. H c2 at the vicinity of the critical temperature T c is related quantitatively to the electrical resistivity ρ, specific heat capacity coefficient γ and T c. H c2 versus tin content is theoretically formulated within the GLAG theory, and generally reproduces the experiment results. As Sn content gradually approaches the stoichiometry, A15-type Nb-Sn undergoes a transition from the dirty limit to clean limit, split by the phase transformation boundary...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442564/on-the-permeation-of-large-organic-cations-through-the-pore-of-atp-gated-p2x-receptors
#10
Mahboubi Harkat, Laurie Peverini, Adrien H Cerdan, Kate Dunning, Juline Beudez, Adeline Martz, Nicolas Calimet, Alexandre Specht, Marco Cecchini, Thierry Chataigneau, Thomas Grutter
Pore dilation is thought to be a hallmark of purinergic P2X receptors. The most commonly held view of this unusual process posits that under prolonged ATP exposure the ion pore expands in a striking manner from an initial small-cation conductive state to a dilated state, which allows the passage of larger synthetic cations, such as N-methyl-d-glucamine (NMDG(+)). However, this mechanism is controversial, and the identity of the natural large permeating cations remains elusive. Here, we provide evidence that, contrary to the time-dependent pore dilation model, ATP binding opens an NMDG(+)-permeable channel within milliseconds, with a conductance that remains stable over time...
April 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28442324/the-interactive-role-of-cb1-receptors-and-l-type-calcium-channels-in-hippocampal-long-term-potentiation-in-rats
#11
Hamidreza Komaki, Fargol Saadat, Siamak Shahidi, Abdolrahman Sarihi, Parisa Hasanein, Alireza Komaki
'Long-term potentiation (LTP) of synaptic responses is a widely researched model of synaptic plasticity that occurs during learning and memory. The cannabinoid system is an endogenous system that modulate this kind of synaptic plasticity. In addition, voltage dependent calcium channels is essential for induction of LTP at some synapses in the hippocampus. However, there is currently debate over the interaction between L-type calcium channels and cannabinoid system on the synaptic plasticity. In this study, we examined the effects of an acute administration of the cannabinoid antagonist AM251 following a chronic administration of the Ca(2+) channel blocker verapamil on LTP induction in the hippocampal dentate gyrus(DG) of rats...
April 22, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28441676/transitioning-from-volume-to-value-one-academic-medical-center-s-approach-to-improving-population-health
#12
Stephanie A C Halvorson, Mary E Tanski, Thomas R Yackel
PROBLEM: The U.S. health care system is undergoing a major transformation. Clinical delivery systems are now being paid according to the value of the care they provide, in accordance with the Triple Aim, which incorporates improving the quality and cost of care and the patient experience. Increasingly, financial risk is being transferred from insurers to clinical delivery systems that become responsible for both episode-based clinical care and the longitudinal care of patients. Thus, these delivery systems need to develop strategies to manage the health of populations...
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441603/assessment-of-wastewater-treatment-facility-compliance-with-decreasing-ammonia-discharge-limits-using-a-regression-tree-model
#13
Bihu Suchetana, Balaji Rajagopalan, JoAnn Silverstein
A regression tree-based diagnostic approach is developed to evaluate factors affecting US wastewater treatment plant compliance with ammonia discharge permit limits using Discharge Monthly Report (DMR) data from a sample of 106 municipal treatment plants for the period of 2004-2008. Predictor variables used to fit the regression tree are selected using random forests, and consist of the previous month's effluent ammonia, influent flow rates and plant capacity utilization. The tree models are first used to evaluate compliance with existing ammonia discharge standards at each facility and then applied assuming more stringent discharge limits, under consideration in many states...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441502/differential-coupling-of-binding-atp-hydrolysis-and-transport-of-fluorescent-probes-with-p-glycoprotein-in-lipid-nanodiscs
#14
Mavis Jiarong Li, Abhinav Nath, William M Atkins
The ATP-binding cassette transporter P-glycoprotein (ABCB1) plays a major role in cellular resistance to drugs, and drug interactions. Experimental studies support a mechanism with nucleotide-dependent fluctuation between inward-facing and outward-facing conformations, which are coupled to nucleotide hydrolysis. However, detailed insight into drug-dependent modulation of these conformational ensembles is lacking. Different drugs likely occupy partially overlapping but distinct sites, and are therefore variably coupled to nucleotide binding and hydrolysis...
April 25, 2017: Biochemistry
https://www.readbyqxmd.com/read/28440982/-intelligence-quotient-loss-in-mexican-pottery-artisan-s-children
#15
Daniel Estrada-Sánchez, Bret Ericson, Cuauhtémoc Arturo Juárez-Pérez, Guadalupe Aguilar-Madrid, Lina Hernández, Sandra Gualtero, Jack Caravanos
BACKGROUND: In Mexico, artisans frequently use lead oxide or greta in order to produce utensils, which are destined to preparation and storage of food and drinks. Additionally, the risk of lead poisoning of artisans and their families is greater than in general population, and within these families, children are the most susceptible to lead poisoning. The aim of this study was to estimate IQ loss in Mexican children from potter families exposed to lead. METHODS: Lead concentrations in soil were determined in 19 potter's homes that functioned as pottery workshops in seven Mexican states between 2009 and 2012...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28440387/thermal-bending-coupled-with-volume-change-in-liquid-crystal-gels
#16
Haruka Doi, Kenji Urayama
We investigate the thermal bending behavior of liquid crystal gels with hybrid alignment (H-LCGs) accompanied by volume change in isotropic and nematic solvents. The curvature (r(-1)) of H-LCGs in each solvent markedly depends on the temperature (T) in the nematic state including the reversal of the bending direction, as in the case of the corresponding elastomers in the dry state (H-LCE). The thermal bending of three systems-H-LCGs in isotropic and nematic solvents and H-LCE-differs significantly in several aspects including the T range where r(-1) depends on T and the total variation of r(-1)...
April 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28439147/a-semi-parametric-transformation-frailty-model-for-semi-competing-risks-survival-data
#17
Fei Jiang, Sebastien Haneuse
In the analysis of semi-competing risks data interest lies in estimation and inference with respect to a so-called non-terminal event, the observation of which is subject to a terminal event. Multi-state models are commonly used to analyse such data, with covariate effects on the transition/intensity functions typically specified via the Cox model and dependence between the non-terminal and terminal events specified, in part, by a unit-specific shared frailty term. To ensure identifiability, the frailties are typically assumed to arise from a parametric distribution, specifically a Gamma distribution with mean 1...
March 2017: Scandinavian Journal of Statistics, Theory and Applications
https://www.readbyqxmd.com/read/28439002/reading-a-400-000-year-record-of-earthquake-frequency-for-an-intraplate-fault
#18
Randolph T Williams, Laurel B Goodwin, Warren D Sharp, Peter S Mozley
Our understanding of the frequency of large earthquakes at timescales longer than instrumental and historical records is based mostly on paleoseismic studies of fast-moving plate-boundary faults. Similar study of intraplate faults has been limited until now, because intraplate earthquake recurrence intervals are generally long (10s to 100s of thousands of years) relative to conventional paleoseismic records determined by trenching. Long-term variations in the earthquake recurrence intervals of intraplate faults therefore are poorly understood...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28438657/the-thiol-of-human-serum-albumin-acidity-microenvironment-and-mechanistic-insights-on-its-oxidation-to-sulfenic-acid
#19
Jenner Bonanata, Lucía Turell, Laura Antmann, Gerardo Ferrer-Sueta, Santiago Botasini, Eduardo Méndez, Beatriz Alvarez, E Laura Coitiño
Human serum albumin (HSA) has a single reduced cysteine residue, Cys34, whose acidity has been controversial. Three experimental approaches (pH-dependence of reactivity towards hydrogen peroxide, ultraviolet titration and infrared spectroscopy) are used to determine that the pKa value in delipidated HSA is 8.1 ± 0.2 at 37°C and 0.1M ionic strength. Molecular dynamics simulations of HSA in the sub-microsecond timescale show that while sulfur exposure to solvent is limited and fluctuating in the thiol form, it increases in the thiolate, stabilized by a persistent hydrogen-bond (HB) network involving Tyr84 and bridging waters to Asp38 and Gln33 backbone...
April 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28438167/dependency-criterion-based-brain-pathological-age-estimation-of-alzheimer-s-disease-patients-with-mr-scans
#20
Yongming Li, Yuchuan Liu, Pin Wang, Jie Wang, Sha Xu, Mingguo Qiu
OBJECTIVES: Traditional brain age estimation methods are based on the idea that uses the real age as the training label. However, these methods ignore that there is a deviation between the real age and the brain age due to the accelerated brain aging. METHODS: This paper considers this deviation and obtains it by maximizing the correlation between the estimated brain age and the class label rather than by minimizing the difference between the estimated brain age and the real age...
April 24, 2017: Biomedical Engineering Online
keyword
keyword
99530
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"