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https://www.readbyqxmd.com/read/29678640/changes-of-glucose-levels-precede-dementia-in-african-americans-with-diabetes-but-not-in-caucasians
#1
Hugh C Hendrie, Mengjie Zheng, Kathleen A Lane, Roberta Ambuehl, Christianna Purnell, Shanshan Li, Frederick W Unverzagt, Michael D Murray, Ashok Balasubramanyam, Chris M Callahan, Sujuan Gao
INTRODUCTION: Changes in glucose levels may represent a powerful metabolic indicator of dementia in African-Americans with diabetes. It is unclear whether these changes also occur in Caucasians. METHODS: A secondary data analysis using electronic medical records from 5228 African-Americans and Caucasians aged ≥65 years was carried out. Mixed effects models with repeated serum glucose measurements were used to compare changes in glucose levels between African-Americans and Caucasian patients with and without incident dementia...
April 17, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29676969/immobilization-of-heavy-metals-in-contaminated-soil-after-mining-activity-by-using-biochar-and-other-industrial-by-products-the-significant-role-of-minerals-on-the-biochar-surfaces
#2
Van Minh Dang, Stephen Joseph, Huu Tap Van, Thi Lan Anh Mai, Thi Minh Hoa Duong, Simon Weldon, Paul Munroe, David Mitchell, Sarasadat Taherymoosavi
Heavy metal contamination of crop lands surrounding mines in North Vietnam is a major environmental issue for both farmers and the population as a whole. Technology for the production of biochar at a village and household level has been successfully introduced into Vietnamese villages. This study was undertaken to determine if rice straw biochar produced in simple drum ovens could remediate contaminated land. Tests were also carried out to determine if biochar and apatite mixed together could be more effective than biochar alone...
April 20, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29675969/exercise-induced-pulmonary-haemorrhage-in-thoroughbred-racehorses-a-longitudinal-study
#3
E J Crispe, C J Secombe, D I Perera, A A Manderson, B A Turlach, G D Lester
BACKGROUND: Exercise induced pulmonary haemorrhage (EIPH) is considered a progressive disease based on histopathology, but it is unknown if tracheobronchoscopic EIPH severity worsens over time. OBJECTIVES: The aim of this study was to examine tracheobronchoscopic EIPH changes over time in a population of Thoroughbred racehorses. A secondary aim was to identify factors that affect changes in tracheobronchoscopic EIPH severity between observations. STUDY DESIGN: Prospective, longitudinal, observational cross-sectional study...
April 20, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29675559/truncated-aptamers-for-total-and-glycated-hemoglobin-and-their-integration-into-a-graphene-oxide-based-fluorometric-method-for-high-throughput-screening-for-diabetes
#4
Abrar Yousef Almusharraf, Shimaa Eissa, Mohammed Zourob
The authors describe the identification of an effective binding region of aptamers against glycated (HbA1c) and total haemoglobin (tHb) by using a fluorometric assay. Truncation of the originally selected aptamers from 60 to 46 and 34 nucleotides for HbA1c and tHb, respectively, enhances the affinity for their targets. Moreover, shortening the aptamer sequences leads to a better conformational change after target binding which enabled the integration of the aptamers in a graphene oxide (GO)-based fluorometric assay...
April 19, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29673832/effects-of-physical-training-with-the-nintendo-wii-fit-plus-%C3%A2-and-protein-supplementation-on-musculoskeletal-function-and-the-risk-of-falls-in-pre-frail-older-women-protocol-for-a-randomized-controlled-clinical-trial-the-wiiprotein-study
#5
Audrin Said Vojciechowski, Simone Biesek, Jarbas Melo Filho, Estela Iraci Rabito, Maryelle Paula do Amaral, Anna Raquel Silveira Gomes
BACKGROUND: Frailty is one of the key geriatric syndromes and is related to the loss of functional independence. However, the practice of physical training (PT) combined with protein supplementation (PS) may improve musculoskeletal function (MF). OBJECTIVE: To verify the effect of PT using 'exergames' with or without PS on MF, nutritional status, and risk of falls in pre-frail older women. METHOD: The protocol is for a randomized controlled clinical trial with a sample of pre-frail older women, divided into 5 groups: control group; PT using exergames; PS; PT using exergames combined with PS; PT using exergames combined with isoenergetic supplementation...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29671377/estimating-under-five-mortality-in-space-and-time-in-a-developing-world-context
#6
Jon Wakefield, Geir-Arne Fuglstad, Andrea Riebler, Jessica Godwin, Katie Wilson, Samuel J Clark
Accurate estimates of the under-five mortality rate in a developing world context are a key barometer of the health of a nation. This paper describes a new model to analyze survey data on mortality in this context. We are interested in both spatial and temporal description, that is wishing to estimate under-five mortality rate across regions and years and to investigate the association between the under-five mortality rate and spatially varying covariate surfaces. We illustrate the methodology by producing yearly estimates for subnational areas in Kenya over the period 1980-2014 using data from the Demographic and Health Surveys, which use stratified cluster sampling...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29669883/impact-of-long-term-erythromycin-therapy-on-the-oropharyngeal-microbiome-and-resistance-gene-reservoir-in-non-cystic-fibrosis-bronchiectasis
#7
Jocelyn M Choo, Guy C J Abell, Rachel Thomson, Lucy Morgan, Grant Waterer, David L Gordon, Steven L Taylor, Lex E X Leong, Steve L Wesselingh, Lucy D Burr, Geraint B Rogers
Long-term macrolide therapy reduces rates of pulmonary exacerbation in bronchiectasis. However, little is known about the potential for macrolide therapy to alter the composition and function of the oropharyngeal commensal microbiota or to increase the carriage of transmissible antimicrobial resistance. We assessed the effect of long-term erythromycin on oropharyngeal microbiota composition and the carriage of transmissible macrolide resistance genes in 84 adults with bronchiectasis, enrolled in the Bronchiectasis and Low-dose Erythromycin Study (BLESS) 48-week placebo-controlled trial of twice-daily erythromycin ethylsuccinate (400 mg)...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29669708/evaluation-of-two-mobile-health-apps-in-the-context-of-smoking-cessation-qualitative-study-of-cognitive-behavioral-therapy-cbt-versus-non-cbt-based-digital-solutions
#8
Carina Tudor-Sfetea, Riham Rabee, Muhammad Najim, Nima Amin, Mehak Chadha, Minal Jain, Kishan Karia, Varun Kothari, Tejus Patel, Melanie Suseeharan, Maroof Ahmed, Yusuf Sherwani, Sarim Siddiqui, Yuting Lin, Andreas B Eisingerich
BACKGROUND: Mobile health (mHealth) apps can offer users numerous benefits, representing a feasible and acceptable means of administering health interventions such as cognitive behavioral therapy (CBT). CBT is commonly used in the treatment of mental health conditions, where it has a strong evidence base, suggesting that it represents an effective method to elicit health behavior change. More importantly, CBT has proved to be effective in smoking cessation, in the context of smoking-related costs to the National Health Service (NHS) having been estimated to be as high as £2...
April 18, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29669516/a-recurrent-silent-mutation-implicates-feca-in-ethanol-tolerance-by-escherichia-coli
#9
Katherine M Lupino, Kymberleigh A Romano, Matthew J Simons, John T Gregg, Leanna Panepinto, Ghislaine M Cruz, Lauren Grajek, Gregory A Caputo, Mark J Hickman, Gregory B Hecht
BACKGROUND: An issue associated with efficient bioethanol production is the fact that the desired product is toxic to the biocatalyst. Among other effects, ethanol has previously been found to influence the membrane of E. coli in a dose-dependent manner and induce changes in the lipid composition of the plasma membrane. We describe here the characterization of a collection of ethanol-tolerant strains derived from the ethanologenic Escherichia coli strain FBR5. RESULTS: Membrane permeability assays indicate that many of the strains in the collection have alterations in membrane permeability and/or responsiveness of the membrane to environmental changes such as temperature shifts or ethanol exposure...
April 18, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29669076/effect-of-lower-energy-higher-fiber-diets-on-pigs-divergently-selected-for-residual-feed-intake-when-fed-higher-energy-lower-fiber-diets
#10
E D Mauch, J M Young, N V L Serão, W L Hsu, J F Patience, B J Kerr, T E Weber, N K Gabler, J C M Dekkers
Residual feed intake (RFI) is the difference between observed and predicted feed intake of an animal, based on growth and maintenance requirements. In Yorkshire pigs, divergent selection for increased (Low RFI) and decreased (High RFI) RFI was carried out over 10 generations (G) while feeding a corn- and soybean-meal-based, higher-energy, lower-fiber (HELF) diet. In G8 to G10, representing 4 replicates, barrows and gilts (n = 649) of the RFI lines were fed the HELF diet and a diet incorporating coproducts that were lower in energy and higher in dietary fiber (LEHF)...
April 14, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29668841/the-impact-of-social-isolation-on-pain-interference-a-longitudinal-study
#11
Nicholas V Karayannis, Isabel Baumann, John A Sturgeon, Markus Melloh, Sean C Mackey
Background: Evidence suggests social interactions play an important role in pain perception. Purpose: The aim of this study was to determine whether social isolation (SI) in people with persistent pain determines pain interference (PI) and physical function over time. Methods: Patients seeking care at a tertiary pain management referral center were administered the Patient Reported Outcome Measurement Information System (PROMIS®) SI, PI, physical function, depression, and average pain intensity item banks at their initial consultation and subsequent visits as part of their routine clinical care...
April 12, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29666240/urbanization-prolongs-hantavirus-epidemics-in-cities
#12
Huaiyu Tian, Shixiong Hu, Bernard Cazelles, Gerardo Chowell, Lidong Gao, Marko Laine, Yapin Li, Huisuo Yang, Yidan Li, Qiqi Yang, Xin Tong, Ru Huang, Ottar N Bjornstad, Hong Xiao, Nils Chr Stenseth
Urbanization and rural-urban migration are two factors driving global patterns of disease and mortality. There is significant concern about their potential impact on disease burden and the effectiveness of current control approaches. Few attempts have been made to increase our understanding of the relationship between urbanization and disease dynamics, although it is generally believed that urban living has contributed to reductions in communicable disease burden in industrialized countries. To investigate this relationship, we carried out spatiotemporal analyses using a 48-year-long dataset of hemorrhagic fever with renal syndrome incidence (HFRS; mainly caused by two serotypes of hantavirus in China: Hantaan virus and Seoul virus) and population movements in an important endemic area of south China during the period 1963-2010...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29664632/ph-and-amylase-responsive-carboxymethyl-starch-poly-2-isobutyl-acrylic-acid-hybrid-microgels-as-effective-enteric-carriers-for-oral-insulin-delivery
#13
Liang Liu, Ying Zhang, Shuangjiang Yu, Zhen Zhang, Chaoliang He, Xuesi Chen
Oral delivery of insulin has the potential to revolutionize diabetes care since it is regarded as a non-invasive therapeutic approach without the side effects caused by frequent subcutaneous injection. However, the insulin delivery efficiency through oral route was still limited, likely due to the chemical, enzymatic and absorption barriers. In this study, a novel type of pH- and amylase-responsive microgels as an insulin drug carrier for oral administration was developed to improve the drug delivery efficiency...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29660963/readiness-to-recognize-a-qualitative-case-study-of-educational-identification-of-tbi
#14
David Greene, Pat L Sample, Nicole Johns, Maureen Palmer
BACKGROUND: The educational identification (ED-ID) of students with traumatic brain injury (TBI) has been legislated in numerous states, and TBI has become its own special education category. Questions abound as to whether these changes will lead to more readily identifying these students to provide appropriate special education supports. OBJECTIVE: Elucidate one state's response to legislative changes around ED-ID of TBI. METHODS: This is a phenomenological case study of nine school districts in one state...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29658331/patients-exposure-to-pvc-plasticizers-from-ecmo-circuits
#15
Charlotte Fernandez-Canal, Pierre-Gabriel Pinta, Teuta Eljezi, Virginie Larbre, Sophie Kauffmann, Lionel Camilleri, Bernard Cosserant, Lise Bernard, Bruno Pereira, Jean-Michel Constantin, Gael Grimandi, Valérie Sautou
BACKGROUND: ECMO is a therapeutic act with a high risk of exposure to diethylhexylphthalate (DEHP), plasticizer from PVC tubings. The replacement of this plasticizer with alternative compounds is recommended but the risks associated with the use of new plasticizers have not been evaluated in ECMO situations. METHODS: Ex vivo ECMO models were performed with different flow rates over 6 days to evaluate the migration of plasticizers and their potential toxic risk for patient...
April 16, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29656267/a-naturalistic-examination-of-the-perceived-effects-of-cannabis-on-negative-affect
#16
Carrie Cuttler, Alexander Spradlin, Ryan J McLaughlin
BACKGROUND: Cannabis is commonly used to alleviate symptoms of negative affect. However, a paucity of research has examined the acute effects of cannabis on negative affect in everyday life. The current study provides a naturalistic account of perceived changes in symptoms of depression, anxiety, and stress as a function of dose and concentration of Δ9 tetrahydrocannabinol (THC) and cannabidiol (CBD). METHOD: Data from the app StrainprintTM (which provides medical cannabis users a means of tracking changes in symptoms as a function of different doses and chemotypes of cannabis) were analyzed using multilevel modeling...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29655933/-document-management-systems-to-support-quality-management-systems-at-university-hospitals-an-interview-based-study
#17
Martin Holderried, Ann-Catrin Bökel, Elke Ochsmann
In order to save and control the processes and quality of medical services, a suitable steering system of all relevant documents is essential from the point of view of clinical quality management. Systems supporting an automated steering system of documents are called document management systems (DMS), and they also enter the healthcare sector. The use of DMS in the German healthcare sector has hardly been investigated so far. To close this knowledge gap, interviews were carried out with German university hospitals over a six-month period and subjected to a qualitative content analysis according to Mayring...
April 12, 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29653361/lncrna-asap1-it1-positively-modulates-the-development-of-cholangiocarcinoma-via-hedgehog-signaling-pathway
#18
Linqi Guo, Yu Zhou, Ying Chen, Huawei Sun, Yue Wang, Yikun Qu
Over the past decades, lncRNAs have attracted more and more attentions of researchers. It has been verified that lncRNAs can modulate multiple biological behaviors in various human cancers. LncRNA ASAP1-IT1 has been certified to be a tumor facilitator in several malignant tumors. This study aims to investigate the effects of dysregulated ASAP1-IT1 on biological processes of Cholangiocarcinoma. The high expression level of ASAP1-IT1 was tested in Cholangiocarcinoma tissues and cells with qRT-PCR. Upregulation of ASAP1-IT predicted the unfavorable prognosis for Cholangiocarcinoma patients...
April 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29653312/improved-chemo-photothermal-therapy-of-hepatocellular-carcinoma-using-chitosan-coated-gold-nanoparticles
#19
Dina S Salem, Mahmoud A Sliem, Mohamed El-Sesy, Samia A Shouman, Yehia Badr
A green method was used for producing gold nanoparticles (Au NPs) using chitosan as a natural cationic, biodegradable and biocompatible polymer. In this method, chitosan acts as a reducing and stabilizing agent for the synthesis of Au NPs. Different concentrations of chitosan solutions (0.01%, 0.05%, 0.1%, 0.2%, 0.5% and 1%) were applied. In an attempt to mitigate the side effects of anti-cancer drug, 5-fluorouracil (5-FU), through reducing drug doses in photothermal therapy, the formed positively-charged chitosan-wrapped Au NPs were used as a drug delivery system for negatively charged 5-FU to hepatocellular carcinoma cells (HepG2)...
April 4, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29653056/uv-photolysis-of-chloramine-and-persulfate-for-1-4-dioxane-removal-in-reverse-osmosis-permeate-for-potable-water-reuse
#20
Wei Li, Samuel Patton, Jamie M Gleason, Stephen Peter Mezyk, Kenneth P Ishida, Haizhou Liu
A sequential combination of membrane treatment and UV-based advanced oxidation processes (UV/AOP) has become the industry standard for potable water reuse. Chloramines are used as membrane anti-fouling agents and therefore carried over into the UV/AOP. In addition, persulfate (S2O82-) is an emerging oxidant which can be added into a UV/AOP, thus creating radicals generated from both chloramines and persulfate for water treatment. This study investigated the simultaneous photolysis of S2O82- and monochloramine (NH2Cl) on the removal of 1,4-dioxane (1,4-D) for potable water reuse...
April 13, 2018: Environmental Science & Technology
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