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https://www.readbyqxmd.com/read/28549899/utility-of-published-dna-reactivity-alerts
#1
Alun Myden, Sebastien Guesne, Alex Cayley, Richard V Williams
The identification of impurities with mutagenic potential is required for any potential pharmaceutical. The ICH M7 guidelines state that two complementary in silico toxicity prediction tools may be used to predict the mutagenic potential of pharmaceutical impurities. An expert review of the resulting in silico predictions is required, and numerous publications have been released to guide the expert review process. One such publication suggests that literature-based structural alerts (LBSAs) may provide a suitable aid in the expert review process...
May 23, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28549531/targeting-the-akt-gsk-3-bcl-2-axis-in-acute-myeloid-leukemia
#2
REVIEW
Maria Rosaria Ricciardi, Simone Mirabilii, Roberto Licchetta, Monica Piedimonte, Agostino Tafuri
Over the last few decades, there has been significant progress in the understanding of the pathogenetic mechanisms of the Acute Myeloid Leukemia (AML). However, despite important advances in elucidating molecular mechanisms, the treatment of AML has not improved significantly, remaining anchored at the standard chemotherapy regimen "3 + 7", with the prognosis of patients remaining severe, especially for the elderly and for those not eligible for transplant procedures. The biological and clinical heterogeneity of AML represents the major obstacle that hinders the improvement of prognosis and the identification of new effective therapeutic approaches...
May 19, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28549254/comparative-early-stage-assessment-of-multiproduct-biorefinery-systems-an-application-to-the-isobutanol-platform
#3
Jonathan Moncada, John A Posada, Andrea Ramírez
An early stage assessment method is applied to the production of isobutanol from lignocellulosic biomass, and to three multiproduct portfolios from the conversion of isobutanol: Case 1: production of isobutyl acetate and glycerol tert-butyl ether (GTBE), Case 2: production of isobutyl acetate and ketones, and Case 3: production of isobutyl acetate alkanes. The method screens and compares each route with its equivalent petrochemical counterpart. The method is composed by different indicators involving economic and environmental aspects...
May 15, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28548631/effectiveness-of-a-respiratory-day-hospital-program-to-reduce-admissions-for-exacerbation-in-patients-with-severe-copd-a-prospective-multicenter-study
#4
Daniel Huertas, Concepción Montón, Alicia Marín, Ingrid Solanes, Marta López-Sánchez, Xavier Pomares, Mariana Muñoz-Esquerre, Jordi Dorca, Salud Santos
The respiratory Day Hospital (DH) is a care facility currently operating at various healthcare institutions. It monitors patients with severe chronic obstructive pulmonary disease (COPD) presenting repeated exacerbations with at least two hospital admissions per year. The main aim of the study was to evaluate the effectiveness of the DH program for controlling admissions for COPD exacerbations in this cohort of patients, and to identify clinical factors associated with hospitalizations and mortality. An observational prospective multicenter study was carried out at three hospitals...
June 2017: COPD
https://www.readbyqxmd.com/read/28548469/trends-in-breast-cancer-epidemiology-in-chelyabinsk-region-2006-2015
#5
Irina A Aksenova, Malcolm A Moore, Alla S Domozhirova
Breast cancer among women occupies a leading position in the profile of cancer incidence in most parts of the world. The present study of the incidence and prevalence of breast cancer was carried out using data from the Chelyabinsk population cancer registry for 2006-2015. A stable growth trend in the incidence over time was noted overall, as well as major differences in the figures for women of different ethnicities (Russian, Tatar, Bashkir), by far the highest incidences being observed for Russian women. Urban rates were generally higher than in rural sites and a shift towards older age at presentation was seen between 2006 and 2015...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28546896/study-of-the-correlation-between-sensing-performance-and-surface-morphology-of-inkjet-printed-aqueous-graphene-based-chemiresistors-for-no2-detection
#6
F Villani, C Schiattarella, T Polichetti, R Di Capua, F Loffredo, B Alfano, M L Miglietta, E Massera, L Verdoliva, G Di Francia
The extremely high sensitivity to the external environment and the high specific surface area, as well as the absence of bulk phenomena that could interfere with the response signal, make graphene highly attractive for the applications in the field of sensing. Among the various methods for producing graphene over large areas, liquid phase exfoliation (LPE) appears to be very promising, especially if combined with inkjet printing (IJP), which offers several advantages, including the selective and controlled deposition of small ink volumes and the versatility of the exploitable inks and substrates...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28546885/a-prospective-study-of-adolescents-sexual-partnerships-on-emerging-adults-relationship-satisfaction-and-intimate-partner-aggression
#7
Monica A Longmore, Wendy D Manning, Jennifer E Copp, Peggy C Giordano
We examined whether the influence of adolescents' sexual partnerships, both dating and casual, carried over to affect emerging adults' relationship satisfaction and experiences of intimate partner aggression. Analyses of longitudinal data from the Toledo Adolescent Relationships Study (n = 294) showed that net of control variables (delinquency, depression, family violence, relational and sociodemographic characteristics), adolescents' number of dating, but not casual, sexual partners led to greater odds of intimate partner aggression during emerging adulthood...
December 2016: Emerging Adulthood
https://www.readbyqxmd.com/read/28546841/the-effect-of-cyclodextrin-complexation-on-the-solubility-and-photostability-of-nerolidol-as-pure-compound-and-as-main-constituent-of-cabreuva-essential-oil
#8
Joyce Azzi, Pierre-Edouard Danjou, David Landy, Steven Ruellan, Lizette Auezova, Hélène Greige-Gerges, Sophie Fourmentin
Nerolidol (Ner), a major component of many plant essential oils, is known for its various biological properties. However, the low solubility of Ner in water and its susceptibility to degradation limit its application. The aim of our study was to improve the solubility and photostability of Ner through its encapsulation in different cyclodextrins (CDs). The formation constants of cis-, trans-Ner and their commercial mixture with various CDs (α-CD, β-CD, γ-CD, HP-β-CD, RAMEB, CRYSMEB and SBE-β-CD) were determined by phase solubility studies and confirmed by the spectral displacement UV-visible method...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28546560/potential-decline-in-carbon-carrying-capacity-under-projected-climate-wildfire-interactions-in-the-sierra-nevada
#9
Shuang Liang, Matthew D Hurteau, Anthony LeRoy Westerling
Ecosystem carbon carrying capacity (CCC) is determined by prevailing climate and natural disturbance regimes, conditions that are projected to change significantly. The interaction of changing climate and its effects on disturbance regimes is expected to affect forest regeneration and growth, which may diminish forest carbon (C) stocks and uptake. We modeled landscape C dynamics over 590 years along the latitudinal gradient of the U.S. Sierra Nevada Mountains under climate and area burned by large wildfires projected by late 21(st) century...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28545187/enterolactone-suppresses-proliferation-migration-and-metastasis-of-mda-mb-231-breast-cancer-cells-through-inhibition-of-upa-induced-plasmin-activation-and-mmps-mediated-ecm-remodeling
#10
Aniket V Mali, Asavari A Joshi, Mahabaleshwar V Hegde, Shivajirao S Kadam
Background: To enhance their own survival, tumor cells can manipulate their microenvironment through remodeling of the extra cellular matrix (ECM). The urokinase-type plasminogen activator (uPA) system catalyzes plasmin production which further mediates activation of matrix metalloproteinases (MMPs) and plays an important role in breast cancer invasion and metastasis through ECM remodeling. This provides a potential target for therapeutic intervention of breast cancer treatment. Enterolactone (EL) is derived from dietary flax lignans in the human body and is known to have anti-breast cancer activity...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28544259/periodontal-maintenance-following-active-specialist-treatment-should-patients-stay-put-or-return-to-primary-dental-care-for-continuing-care-a-comparison-of-outcomes-based-on-the-literature
#11
REVIEW
P G Leavy, D P Robertson
OBJECTIVES: To review the evidence for the efficacy of periodontal maintenance (PM) carried out in primary dental care (PDC) compared to the specialist setting for patients previously treated in a specialist setting for chronic (ChP) or aggressive (AgP) periodontitis. METHODS: A focused PICO question and search protocol were developed. Online databases including MEDLINE, EMBASE, WEB OF SCIENCE™ and COCHRANE LIBRARY were searched along with specialist journals in the subject area of periodontal research...
May 22, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28543831/selective-bromination-of-graphene-oxide-by-hunsdiecker-reaction
#12
Ondrej Jankovsky, Michal Lojka, Jan Luxa, David Sedmidubsky, Ondrej Tomanec, Radek Zboril, Martin Pumera, Zdenek Sofer
Halogenated graphenes have been attracting great attention in the recent years. The currently used methods are usually non-specific and halogen groups are randomly distributed over the graphene surface. The selective functionalization based on well known reaction mechanism allowed selective functionalization of graphene sheets. We show the application of Hunsdicker based reaction on the graphene oxide for selective bromination of graphene oxide. The chemical analysis using various spectroscopic methods proved a highly effective functionalization...
May 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28543614/capillarys-2-flex-piercing-analytical-performance-assessment-according-to-clsi-protocols-for-hba1c-quantification
#13
Radhouene Doggui, Chaïma Abdelhafidh Sahli, Wassef Lotfi Aissa, Maroua Hammami, Maha Ben Sedrine, Rahma Mahjoub, Khemais Zouaoui, Rim Daboubi, Hajer Siala, Taieb Messaoud, Amina Bibi
HbA1c is used for monitoring diabetic balance. In this paper we report an assessment of the analytical performances of Capillarys 2 Flex Piercing (C2FP) for HbA1c measurement using CE (Capillary Electrophoresis). CLSI (Clinical and Laboratory Standard Institute) protocols are used for the evaluation of apparatus performances: precision, linearity, method comparison, truness and common interferences. HbA1c CVs average in intra-assay was 1.6% between run imprecision CV ranged from0.1 to 1.8%. The linearity was demonstrated between 4...
May 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28540026/meta-analysis-of-gwas-of-over-16-000-individuals-with-autism-spectrum-disorder-highlights-a-novel-locus-at-10q24-32-and-a-significant-overlap-with-schizophrenia
#14
(no author information available yet)
BACKGROUND: Over the past decade genome-wide association studies (GWAS) have been applied to aid in the understanding of the biology of traits. The success of this approach is governed by the underlying effect sizes carried by the true risk variants and the corresponding statistical power to observe such effects given the study design and sample size under investigation. Previous ASD GWAS have identified genome-wide significant (GWS) risk loci; however, these studies were of only of low statistical power to identify GWS loci at the lower effect sizes (odds ratio (OR) <1...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28539725/inhibition-of-cytochrome-p450-cyp3a4-activity-by-extracts-from-57-plants-used-in-traditional-chinese-medicine-tcm
#15
Mohamed L Ashour, Fadia S Youssef, Haidy A Gad, Michael Wink
BACKGROUND: Herbal medicine is widely used all over the world for treating various health disorders. It is employed either alone or in combination with synthetic drugs or plants to be more effective. OBJECTIVE: The assessment of the effect of both water and methanol extracts of 57 widely used plants from Traditional Chinese Medicine (TCM) against the main phase I metabolizing enzyme CYP3A4 in vitro for the first time. MATERIALS AND METHODS: The inhibition of cytochrome P450 activity was evaluated using a luminescence assay...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28537506/efficacy-and-safety-of-tapentadol-prolonged-release-for-moderate-to-severe-chronic-osteoarthritis-knee-pain-a-pooled-analysis-of-two-double-blind-randomized-placebo-and-oxycodone-controlled-release-studies
#16
Bernd Lange, Detlef von Zabern, Christian Elling, Cecile Dubois
OBJECTIVE: To compare efficacy and safety of tapentadol prolonged-release (PR) and oxycodone-controlled release (CR) in moderate to severe chronic osteoarthritis knee pain. METHODS: Data from two double-blind, randomized, placebo- and oxycodone CR-controlled phase 3 studies with 3-week titration period and 12-week controlled dose adjustment maintenance period were pooled. Primary efficacy endpoints were change from baseline in average pain intensity at week 12 (US endpoint) and over the entire maintenance period (non-US endpoint)...
May 24, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28537501/tapentadol-prolonged-release-for-moderate-to-severe-chronic-osteoarthritis-knee-pain-a-double-blind-randomized-placebo-and-oxycodone-controlled-study
#17
Alain Serrie, Bernd Lange, Achim Steup
OBJECTIVE: To assess efficacy and safety of tapentadol prolonged release (PR) for moderate-to-severe chronic osteoarthritis knee pain. METHODS: Patients (n = 990) were randomized (1:1:1) to tapentadol PR, oxycodone controlled release (CR; reference compound for assay sensitivity), or placebo for a double-blind 3-week titration and 12-week maintenance period. Primary efficacy endpoints were change from baseline in average pain intensity at week 12 of maintenance (US endpoint) and over the entire maintenance period (non-US endpoint) with 'last observation carried forward' as imputation method for missing scores...
May 24, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28537217/effect-of-the-sulphur-atom-on-geometry-and-spectra-of-the-biomolecule-2-thiouracil-and-in-the-wc-base-pair-2-thiouridine-adenosine-influence-of-water-in-the-first-hydration-shell
#18
M Alcolea Palafox, V K Rastogi, S P Singh
The effect of the sulphur atom on 2-thiouracil (2TU) and 2-thiouridine molecules, as compared with uracil and uridine molecules, respectively, was carried out in several environments. The predicted IR spectrum of 2TU in the isolated state was compared with that obtained for uracil molecule and with those reported experimentally in matrix isolation. Its crystal unit cell in the solid state was simulated through a tetramer form using DFT methods for the first time. The calculated Raman spectrum was compared to the experimental ones in the solid state...
May 24, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28537035/characteristics-of-columnar-aerosol-optical-and-microphysical-properties-retrieved-from-the-sun-photometer-and-its-impact-on-radiative-forcing-over-skukuza-south-africa-during-1999-2010
#19
Ayodele Joseph Adesina, Stuart Piketh, Raghavendra Kumar Kanike, Sivakumar Venkataraman
The detailed analysis of columnar optical and microphysical properties of aerosols obtained from the AErosol RObotic NETwork (AERONET) Cimel sun photometer operated at Skukuza (24.98° S, 31.60° E, 150 m above sea level), South Africa was carried out using the level 2.0 direct sun and inversion products measured during 1999-2010. The observed aerosol optical depth (AOD) was generally low over the region, with high values noted in late winter (August) and mid-spring (September and October) seasons. The major aerosol types found during the study period were made of 3...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28535693/experience-with-sunitinib-in-metastatic-renal-cell-carcinoma-mrcc-patients-pooled-analysis-from-3-spanish-observational-prospective-studies
#20
Daniel Castellano, José Pablo Maroto, Enrique Espinosa, Enrique Grande, Victoria Bolos, Julia Linares, Emilio Esteban, Aranzazu Gonzalez Del Alba, M A Climent, J A Arranz, Mª José Méndez, Eva Fernadez Parra, Luis Antón-Aparicio, Cristina Bayona, Isabel Gallegos, Enrique Gallardo, Luz Samaniego, J Garcia Donas
BACKGROUND: A pivotal, randomized, phase III trial demonstrated a statistically significant superiority of sunitinib over interferon-α in metastatic renal cell carcinoma (mRCC) patients. OBJECTIVE: To evaluate the effectiveness and safety of sunitinib in patients with advanced or mRCC in routine clinical practice. METHODS: Retrospective pooled analysis of clinical data from three observational and prospective studies carried out between 2007 and 2011 in 33 Spanish hospitals...
May 24, 2017: Expert Opinion on Drug Safety
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