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https://www.readbyqxmd.com/read/29351783/simple-citrate-anticoagulation-protocol-for-low-flux-haemodialysis
#1
Eng Kuang Lim, Ying-Ying T Seow, Shun E Chen, Gao Yang, Min Er Liaw, Shimi Isaac
BACKGROUND: For patients unable to receive heparin anticoagulation during haemodialysis, saline flushes to reduce circuit clotting are often the norm. Regional citrate anticoagulation (RCA) although effective is not used by many centres including in Singapore. We wanted to demonstrate the superiority and safety of a simple regional citrate anticoagulation regime, compared to saline flushes, for heparin-free low flux haemodialysis. METHODS: This is a prospective, open label, cross over study on 25 sequential haemodialysis sessions for inpatients receiving heparin-free haemodialysis...
January 19, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29350475/water-deficit-disrupts-male-gametophyte-development-in-quercus-ilex
#2
Olga Bykova, Jean-Marc Limousin, Jean-Marc Ourcival, Isabelle Chuine
Tree species distribution, and hence forest biodiversity, rely on the reproductive capacity of trees which is currently affected by climate change. Drought-induced pollen sterility could increase as a consequence of more intense and more frequent droughts projected for temperate and Mediterranean regions and threaten the sexual regeneration of trees in these regions. To evaluate this possibility, we examined the effect of long-term partial rainfall exclusion (-27% of precipitation) on male reproductive development in holm oak, Quercus ilex, one of the most important and widespread tree species of the Mediterranean region...
January 19, 2018: Plant Biology
https://www.readbyqxmd.com/read/29347452/incorporating-born-solvation-energy-into-the-three-dimensional-poisson-nernst-planck-model-to-study-ion-selectivity-in-kcsa-k-channels
#3
Xuejiao Liu, Benzhuo Lu
Potassium channels are much more permeable to potassium than sodium ions, although potassium ions are larger and both carry the same positive charge. This puzzle cannot be solved based on the traditional Poisson-Nernst-Planck (PNP) theory of electrodiffusion because the PNP model treats all ions as point charges, does not incorporate ion size information, and therefore cannot discriminate potassium from sodium ions. The PNP model can qualitatively capture some macroscopic properties of certain channel systems such as current-voltage characteristics, conductance rectification, and inverse membrane potential...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347101/formation-of-liquid-drops-at-an-orifice-and-dynamics-of-pinch-off-in-liquid-jets
#4
Manash Pratim Borthakur, Gautam Biswas, Dipankar Bandyopadhyay
This paper presents a numerical investigation of the dynamics of pinch-off in liquid drops and jets during injection of a liquid through an orifice into another fluid. The current study is carried out by solving axisymmetric Navier-Stokes equations and the interface is captured using a coupled level-set and volume-of-fluid approach. The delicate interplay of inertia and viscous effects plays a crucial role in deciding the dynamics of the formation as well as breakup of liquid drops and jets. In the dripping regime, the growth and breakup rate of a drop are studied and quantified by corroborating with theoretical predictions...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346316/chronic-dietary-intake-of-enniatin-b-in-broiler-chickens-has-low-impact-on-intestinal-morphometry-and-hepatic-histology-and-shows-limited-transfer-to-liver-tissue
#5
Sophie Fraeyman, Siska Croubels, Mathias Devreese, Richard Ducatelle, Michael Rychlik, Gunther Antonissen
The Fusarium mycotoxin enniatin B (ENN B) is a so-called emerging mycotoxin frequently contaminating poultry feed. To investigate the impact of chronic ENN B exposure on animal health, broiler chickens were fed either a diet naturally contaminated with ENN B (2352 µg/kg) or a control diet (135 µg/kg) for 2, 7, 14, or 21 days. ENN B concentrations were determined in plasma and liver using a validated ultra-high performance liquid chromatography-tandem mass spectrometry UHPLC-MS/MS method. Liver was evaluated histologically, and the villus length and crypt depth of the duodenum, jejunum, and ileum were measured...
January 18, 2018: Toxins
https://www.readbyqxmd.com/read/29341503/tadalafil-5-mg-once-daily-improves-lower-urinary-tract-symptoms-and-erectile-dysfunction-a-systematic-review-and-meta-analysis
#6
Yilin Wang, Yiping Bao, Jie Liu, Lijun Duan, Yuanshan Cui
OBJECTIVES: We carried out a systematic review and meta-analysis to assess tadalafil 5 mg once-daily for the treatment of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). METHODS: A literature review was performed to identify all published randomized double-blind, placebo-controlled trials of tadalafil 5 mg once-daily for the treatment of LUTS and ED. The search included the following databases: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register...
January 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29340893/a-prospective-study-of-humoral-and-cellular-immune-responses-to-hepatitis-b-vaccination-in-habitual-marijuana-smokers
#7
Sylvia M Kiertscher, Pallavi R Gangalum, Grace Ibrahim, Donald P Tashkin, Michael D Roth
Exposure to Δ9-tetrahydrocannabinol (THC) in vitro and in animal models can significantly impair the differentiation, activation and function of dendritic cells, T cells and B cells. However, studies directly assessing the impact of marijuana smoking on human immunity are lacking. A prospective study of immune responses to a standard hepatitis B vaccination was therefore carried out in a matched cohort of 9 marijuana smokers (MS) and 9 nonsmokers (NS). In addition to their regular marijuana use, MS smoked four marijuana cigarettes in a monitored setting on the day of each vaccination...
January 16, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29340311/hyponatremia-and-the-brain
#8
REVIEW
Fabrice Gankam Kengne, Guy Decaux
Hyponatremia is defined by low serum sodium concentration and is the most common electrolyte disorder encountered in clinical practice. Serum sodium is the main determinant of plasma osmolality, which, in turn, affects cell volume. In the presence of low extracellular osmolality, cells will swell if the adaptation mechanisms involved in the cell volume maintenance are inadequate. The most dramatic effects of hyponatremia on the brain are seen when serum sodium concentration decreases in a short period, allowing little or no adaptation...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29340208/are-they-publishing-a-descriptive-cross-sectional-profile-and-bibliometric-analysis-of-the-journal-publication-productivity-of-italian-physiotherapists
#9
Stefano Vercelli, Elisa Ravizzotti, Matteo Paci
Background: In a clinical science-based profession such as physiotherapy, research is mandatory to update knowledge and to provide cost-effective, high quality treatments. This study aimed to provide point prevalence of Italian physiotherapists who are academics, holding a PhD degree, or being authors of scientific papers. The scientific journal productivity of physiotherapists was also thoroughly analyzed. Methods: A descriptive cross-sectional study was carried out on all Italian physiotherapists...
2018: Archives of Physiotherapy
https://www.readbyqxmd.com/read/29339418/an-evolutionary-biochemical-connection-between-promoter-and-primer-dependent-polymerases-revealed-by-selective-evolution-of-ligands-by-exponential-enrichment-selex
#10
Katherine J Fenstermacher, Vasudevan Achuthan, Thomas D Schneider, Jeffrey J DeStefano
DNA polymerases (DNAPs) recognize 3' recessed termini on duplex DNA and carry out nucleotide catalysis. Unlike promoter-specific RNA polymerases (RNAPs), no sequence specificity is required for binding or initiation of catalysis. Despite this, previous results indicate that viral reverse transcriptases bind much more tightly to DNA primers that mimic the polypurine tract. In the current report, primer sequences that bind with high affinity to Taq and Klenow polymerases were identified using a modified Selective Evolution of Ligands by Exponential Enrichment (SELEX) approach...
January 16, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29338743/the-prospective-and-concurrent-effect-of-exercise-on-health-related-quality-of-life-in-older-adults-over-a-3%C3%A2-year-period
#11
Helen-Maria Vasiliadis, Mathieu F Bélanger
BACKGROUND: It is not clear whether socioeconomic status influences health outcomes among older adults through its effect on physical activity. The aim of this study was to assess the effect of sex and neighborhood socio-economic status on the change in health related quality of life (HR-QOL) as a function of physical activity over a three-year period. METHODS: This cohort study included French-speaking community-dwelling older adults recruited in primary care practices in the province of Quebec and participating in the 'Étude sur la Santé des Ainés' (ESA)-Services study on the health of the elderly...
January 16, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29338038/does-the-leading-pharmaceutical-reform-in-china-really-solve-the-issue-of-overly-expensive-healthcare-services-evidence-from-an-empirical-study
#12
Yunzhen He, Guanshen Dou, Qiaoyun Huang, Xinyu Zhang, Yingfeng Ye, Mengcen Qian, Xiaohua Ying
BACKGROUND: Healthcare system reform of Sanming city has become a leading healthcare reform model in China. It has developed a rigorous pharmaceutical reform consisted of the Zero Mark-up Drug Policy and the Centralized Procurement of Medicine Policy to bring down drug expenses and total health expenditures. However, despite the credit and much attention have been given to Sanming's pharmaceutical reform, its impact still remains unclear. Therefore, the purpose of this study was to explore the impact of the pharmaceutical reform of Sanming on both drug and total health expenditures...
2018: PloS One
https://www.readbyqxmd.com/read/29337897/long-term-mechanical-behavior-of-nano-silica-sol-grouting
#13
Dongjiang Pan, Nong Zhang, Chenghao Zhang, Deyu Qian, Changliang Han, Sen Yang
The longevity of grouting has a significant effect on the safe and sustainable operation of many engineering projects. A 500-day experiment was carried out to study the long-term mechanical behavior of nano silica sol grouting. The nano silica sol was activated with different proportions of a NaCl catalyst and cured under fluctuating temperature and humidity conditions. The mechanical parameters of the grout samples were tested using an electrohydraulic uniaxial compression tester and an improved Vicat instrument...
January 16, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29337397/2d-pdag-alloy-nanodendrites-for-enhanced-ethanol-electroxidation
#14
Wenjing Huang, Xiaolin Kang, Cheng Xu, Junhua Zhou, Jun Deng, Yanguang Li, Si Cheng
The development of highly active and stable electrocatalysts for ethanol electroxidation is of decisive importance to the successful commercialization of direct ethanol fuel cells. Despite great efforts invested over the past decade, their progress has been notably slower than expected. In this work, the facile solution synthesis of 2D PdAg alloy nanodendrites as a high-performance electrocatalyst is reported for ethanol electroxidation. The reaction is carried out via the coreduction of Pd and Ag precursors in aqueous solution with the presence of octadecyltrimethylammonium chloride as the structural directing agent...
January 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29337327/modulating-inflammation-in-a-cutaneous-chronic-wound-model-by-il-10-released-from-collagen-silica-nanocomposites-via-gene-delivery
#15
Xiaolin Wang, Thibaud Coradin, Christophe Hélary
Cutaneous chronic wounds remain a major clinical challenge which requires the development of novel wound dressings. Previously, we showed that collagen-silica nanocomposites consisting of polyethyleneimine (PEI)-DNA complexes associated with silica nanoparticles (SiNP), collagen hydrogel and 3T3 fibroblasts, can work as a local "cell factory". Indeed, the "in-gel" transfection leads to a sustained production and release of biomolecules. Herein, we further explored the possibility for nanocomposites to deliver interleukin-10 (IL-10), a potent anti-inflammatory cytokine, which favors tissue repair...
January 16, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29336009/gefitinib-for-advanced-non-small-cell-lung-cancer
#16
REVIEW
Esther Ha Sim, Ian A Yang, Richard Wood-Baker, Rayleen V Bowman, Kwun M Fong
BACKGROUND: The role of gefitinib for the treatment of advanced non-small cell lung cancer (NSCLC) is evolving. We undertook a systematic review to evaluate the available evidence from all randomised trials. OBJECTIVES: To determine the effectiveness and safety of gefitinib as first-line, second-line or maintenance treatment for advanced NSCLC. SEARCH METHODS: We performed searches in CENTRAL, MEDLINE and Embase from inception to 17 February 2017...
January 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29335788/over-expression-of-a-grafting-responsive-gene-from-hickory-increases-abiotic-stress-tolerance-in-arabidopsis
#17
R M Saravana Kumar, Guocun Ji, Haipeng Guo, Liang Zhao, Bingsong Zheng
A grafting response gene CcPIP1;2 was cloned from hickory plant, further functional characterization of the gene for water transport activity and abiotic stress tolerances were carried out through heterologous expression in Xenopus and Arabidopsis. Plasma membrane intrinsic proteins (PIPs) are multifunctional channel proteins belonging to the membrane intrinsic protein (MIP) family. In this study, a grafting-responsive gene from hickory (CcPIP1;2) was cloned and functionally characterized. Application of non-selective water inhibitors (HgCl2 and phloretin) led to the death of grafted hickory plants at 30 days after grafting (DAG)...
January 15, 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29335168/wrf-modeling-of-pm2-5-remediation-by-salscs-and-its-clean-air-flow-over-beijing-terrain
#18
Qingfeng Cao, Lian Shen, Sheng-Chieh Chen, David Y H Pui
Atmospheric simulations were carried out over the terrain of entire Beijing, China, to investigate the effectiveness of an air-pollution cleaning system named Solar-Assisted Large-Scale Cleaning System (SALSCS) for PM2.5 mitigation by using the Weather Research and Forecasting (WRF) model. SALSCS was proposed to utilize solar energy to generate airflow therefrom the airborne particulate pollution of atmosphere was separated by filtration elements. Our model used a derived tendency term in the potential temperature equation to simulate the buoyancy effect of SALSCS created with solar radiation on its nearby atmosphere...
January 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29334843/high-genetic-diversity-and-low-population-differentiation-in-the-patagonian-sprat-sprattus-fuegensis-based-on-mitochondrial-dna
#19
Cristian B Canales-Aguirre, Sandra Ferrada-Fuentes, Ricardo Galleguillos, Fernanda X Oyarzun, Claudio C Buratti, Cristián E Hernández
The Patagonian sprat, Sprattus fuegensis, is a small pelagic marine fish that inhabits the continental shelf along the coasts of Chilean Patagonian and Argentina, a distribution that was highly impacted during the Last Glacial Maximum (LGM). In order to identify how the LGM played a role on the current observed genetic diversity and population structure of S. fuegensis, we analyzed 1438 nucleotide positions from the control region of 335 individuals collected at 12 sites across its distribution. Genetic diversity and differentiation indices were calculated to identify population structure, and a Bayesian skyride plot (BSRP) reconstruction was carried out to infer the historic population dynamics...
January 15, 2018: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29334369/dual-gene-activation-and-knockout-screen-reveals-directional-dependencies-in-genetic-networks
#20
Michael Boettcher, Ruilin Tian, James A Blau, Evan Markegard, Ryan T Wagner, David Wu, Xiulei Mo, Anne Biton, Noah Zaitlen, Haian Fu, Frank McCormick, Martin Kampmann, Michael T McManus
Understanding the direction of information flow is essential for characterizing how genetic networks affect phenotypes. However, methods to find genetic interactions largely fail to reveal directional dependencies. We combine two orthogonal Cas9 proteins from Streptococcus pyogenes and Staphylococcus aureus to carry out a dual screen in which one gene is activated while a second gene is deleted in the same cell. We analyze the quantitative effects of activation and knockout to calculate genetic interaction and directionality scores for each gene pair...
January 15, 2018: Nature Biotechnology
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