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https://www.readbyqxmd.com/read/29775747/mediterranean-diet-and-depression-among-older-individuals-the-multinational-medis-study
#1
Maria F Masana, Josep Maria Haro, Anargiros Mariolis, Suzanne Piscopo, Giuseppe Valacchi, Vassiliki Bountziouka, Foteini Anastasiou, Akis Zeimbekis, Dimitra Tyrovola, Efthimios Gotsis, George Metallinos, Anna Polystipioti, Josep-Antoni Tur, Antonia-Leda Matalas, Christos Lionis, Evangelos Polychronopoulos, Labros S Sidossis, Stefanos Tyrovolas, Demosthenes B Panagiotakos
BACKGROUND: Depression has been linked to a large and growing economic and societal burden worldwide. In Europe, depression is one of the most frequent mental disorders across all age groups, but particularly in people aged 65 years and over, and higher depressive symptoms have been reported among individuals with chronic diseases (e.g., diabetes and heart disease). AIM: To evaluate the role of adherence to the Mediterranean diet (MedDiet) in depression in a sample of older people living in the Mediterranean basin...
May 15, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29775185/bandgap-and-pseudohelicity-effects-over-conductance-in-gapped-graphene-junctures
#2
Jorge Andres Navarro-Giraldo, Carlos Jose Quimbay
We study the conductance in gapped single-layer graphene junctures as a function of bangap, pseudohelicity and charge carriers density. To do it, we first calculate the transmission coefficients of massive charge carries for p-n and n-p-n junctures of gapped single-layer graphene. Next, we calculate the conductance for these two systems using the Landauer formula. Only for the p-n juncture case and non-zero bandgap values, we find the existence of a contribution to the conductance from pseudohelicity inversion states, which is small compared to the contribution from pseudohelicity conservation states...
May 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29775141/effects-of-structured-group-reminiscence-therapy-on-the-life-satisfaction-of-institutionalized-older-adults-in-taiwan
#3
Yao Ching-Teng, Lin Chia-Ju, Liu Hsiu-Yueh
Health issues common among older adults living in institution settings include poor life satisfaction and depression conditions. Engagement in appropriate group reminiscence therapy programs could alleviate these health issues among older adults in long-term care institutions. This study tested the effectiveness of a structured group reminiscence therapy protocol on the life satisfaction of institutionalized older adults. A quasi-experimental design was applied. A convenience sample of older adults was drawn from two nursing homes in southern Taiwan...
May 18, 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29774747/hypertonic-saline-versus-isotonic-saline-nasal-irrigation-systematic-review-and-meta-analysis
#4
Dichapong Kanjanawasee, Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Kornkiat Snidvongs
Background Saline nasal lavage is one of the treatments of sinonasal diseases. Evidence from basic research favors hypertonic saline (HS) over isotonic saline (IS) for mucociliary clearance, but evidence from clinical studies is controversial. Conversely, HS may carry greater side effects. Objective To compare the effects of HS and IS nasal irrigation in treating sinonasal diseases. Methods Systematic search with Ovid MEDLINE, Scopus, PubMed, Google Scholar, and Manual additional sources was conducted. Randomized controlled trials comparing HS with IS nasal irrigation in treating any sinonasal diseases, including rhinitis and rhinosinusitis, were included...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29774369/-effectiveness-of-active-health-promotion-in-old-age-results-regarding-compression-of-morbidity-by-target-groups-in-13-8-years-of-observation-in-lucas
#5
REVIEW
Ulrike Dapp, Christoph Minder, Lilli Neumann, Stefan Golgert, Björn Klugmann, Wolfgang von Renteln-Kruse
BACKGROUND AND OBJECTIVE: Healthy ageing as defined by the World Health Organization (WHO) is the development and maintenance of functional competence. Unfavourable ageing is described by the term frailty and is characterised by a decline in functional reserves. The frailty process can be influenced in a positive way. Previous interventions concerned mostly hospital patients and residents of nursing homes. In this study we examined the maintenance of functional competence in an urban community setting...
May 17, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29774210/hypertension-in-children-role-of-obesity-simple-carbohydrates-and-uric-acid
#6
REVIEW
Antonina Orlando, Emanuela Cazzaniga, Marco Giussani, Paola Palestini, Simonetta Genovesi
Over the past 60 years there has been a dramatic increase in the prevalence of overweight in children and adolescents, ranging from 4% in 1975 to 18% in 2016. Recent estimates indicate that overweight or obese children and adolescents are more than 340 million. Obesity is often associated with hypertension, which is an important cardiovascular risk factor. Recent studies show that the presence of hypertension is a frequent finding in the pediatric age. Hypertensive children easily become hypertensive adults...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29772578/long-term-omalizumab-treatment-a-multicenter-real-life-5-year-trial
#7
Arzu Yorgancıoğlu, Ferda Öner Erkekol, Dilşad Mungan, Münevver Erdinç, Bilun Gemicioğlu, Zeynep Ferhan Özşeker, Papatya Bayrak Değirmenci, Sibel Naycı, Aykut Çilli, Füsun Erdenen, Cengiz Kırmaz, Dane Ediger, Arzu Didem Yalçın, Suna Büyüköztürk, Sami Öztürk, Mustafa Güleç, Sacide Rana Işık, Ali Fuat Kalyoncu, Özlem Göksel, Ömür Aydın, Yavuz Havlucu, İdilhan Baloğlu Ar, Ahmet Erdoğdu
BACKGROUND: Omalizumab has demonstrated therapeutic benefits both in controlled clinical trials and real-life studies. However, research concerning the long-term effects and tolerability of omalizumab is needed. The main objective of this study was to evaluate the effectiveness and tolerability of treatment with omalizumab for up to 5 years. METHODS: A multicenter, retrospective, chart-based study was carried out to compare documented exacerbations, hospitalizations, systemic steroid requirement, FEV1, and asthma control test (ACT) results during 1 year prior to omalizumab treatment versus at 1, 3, and 5 years of treatment...
May 17, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29772462/photocatalytic-mineralization-and-degradation-kinetics-of-sulphamethoxazole-and-reactive-red-194-over-silver-zirconium-co-doped-titanium-dioxide-reaction-mechanisms-and-phytotoxicity-assessment
#8
Saraschandra Naraginti, Yi Li, Gianluca Li Puma
The photodegradation and phytotoxicity of the pharmaceutical antibiotic, sulphamethoxazole (SMX) and the azo-dye reactive-red-194 (RR194) under visible-light irradiation of TiO2 nanoparticles modified by silver and zirconium was investigated. The results indicated that sulphamethoxazole and its toxic degradation by product, 3-amino-5-methylisoxazole and RR-194 could be degraded efficiently by the co-doped Zr/Ag-TiO2 catalyst. PL studies and ROS generation results suggested that the effective charge separation was carried out while irradiation of the modified TiO2 nanoparticles...
May 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29772432/silymarin-prevents-apoptosis-through-inhibiting-the-bax-caspase-3-expression-and-suppresses-toll-like-receptor-4-pathway-in-the-snc-of-6-ohda-intoxicated-rats
#9
Rasool Haddadi, Alireza Mohajjel Nayebi, Shahla Eyvari Brooshghalan
BACKGROUND AND PURPOSE: Several lines of evidence show that apoptosis, oxidative stress and neuroinflammation are associated with the development of Parkinson's disease (PD). In the present study, we investigated the effect of pre-treatment with silymarin (SM) on oxidative stress, apoptosis and toll-like receptor 4 (TLR4) expression in substantia nigra pars copmacta (SNc) of 6-hydroxydopamine (6-OHDA)-lesioned rats. METHODS: Animals were pretreated with 100, 200 or 300 mg/kg of SM daily for 5 days and at 6th day 6-OHDA (8 μg/2 μl) was infused unilaterally into the central region of the SNc...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29772175/systematic-excited-state-studies-of-reversibly-switchable-fluorescent-proteins
#10
Daryna Smyrnova, María Del Carmen Marín, Massimo Olivucci, Arnout Ceulemans
A set formed by five reversibly-switchable fluorescent proteins (RSFPs) display spread over 40~nm in absorption maxima and only 18~nm in emission. The five proteins -- Dronpa, rsFastLime, rsKame, Padron(anionic form) and bsDronpa -- carry exactly the same chromophore and differ just in a few mutations. Thus they form an ideal set for mechanistic investigation. Starting with the results of molecular dynamics simulations we use QM/MM calculations to investigate the effects controlling the spectral tuning . In this contribution we show that the models, which are based on CASPT2//CASSCF level of QM theory, reproduce the observed absorption trend with only a limited blue-shift of 4...
May 17, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29771540/mechanistic-study-of-the-reactions-of-methyl-peroxy-radical-with-methanol-or-hydroxyl-methyl-radical
#11
Zhongrui Zhao, Jinou Song, Boyang Su, Xiaowen Wang, Zhijun Li
An ab initio and direct dynamic study on the reactions of CH3O2 + CH3OH and CH3O2 + CH2OH has been carried out over the temperature range of 300 - 1500 K. All stationary points were calculated at MP2/Aug-cc-pVTZ level of theory for CH3O2 + CH3OH or at M06-2X/MG3S level of theory for CH3O2 + CH2OH and identified for local minimum. The energetic parameters were refined at QCISD (T)/cc-pVTZ and CCSD (T)/aug-cc-pVTZ levels of theory. For the reaction of CH3OO + CH3OH, two hydrogen abstraction channels producing CH3OOH+CH2OH (R1) and CH3OOH+CH3O (R2) were confirmed...
May 17, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29769354/allele-specific-alterations-in-the-peptidome-underlie-the-joint-association-of-hla-a-29-02-and-endoplasmic-reticulum-aminopeptidase-2-erap2-with-birdshot-chorioretinopathy
#12
Alejandro Sanz-Bravo, Adrian Martin-Esteban, Jonas J W Kuiper, Marina García-Peydró, Eilon Barnea, Arie Admon, José A López de Castro
Virtually all patients of the rare inflammatory eye disease birdshot chorioretinopathy (BSCR) carry the HLA-A*29:02 allele. BSCR is also associated with endoplasmic reticulum aminopeptidase 2 (ERAP2), an enzyme involved in processing HLA class I ligands, thus implicating the A*29:02 peptidome in this disease. To investigate the relationship between both risk factors we employed label-free quantitative mass spectrometry to characterize the effects of ERAP2 on the A*29:02-bound peptidome. An ERAP2-negative cell line was transduced with lentiviral constructs containing GFP-ERAP2 or GFP alone, and the A*29:02 peptidomes from both transduced cells were compared...
May 16, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29769301/incubation-behaviours-of-oviraptorosaur-dinosaurs-in-relation-to-body-size
#13
Kohei Tanaka, Darla K Zelenitsky, Junchang Lü, Christopher L DeBuhr, Laiping Yi, Songhai Jia, Fang Ding, Mengli Xia, Di Liu, Caizhi Shen, Rongjun Chen
Most birds sit on their eggs during incubation, a behaviour that likely evolved among non-avian dinosaurs. Several 'brooding' specimens of smaller species of oviraptorosaurs and troodontids reveal these non-avian theropods sat on their eggs, although little is known of incubation behaviour in larger theropod species. Here we examine egg clutches over a large body size range of oviraptorosaurs in order to understand the potential effect of body size on incubation behaviour. Eggshell porosity indicates that the eggs of all oviraptorosaurs were exposed in the nest, similar to brooding birds...
May 2018: Biology Letters
https://www.readbyqxmd.com/read/29768662/immersion-in-water-during-labour-and-birth
#14
REVIEW
Elizabeth R Cluett, Ethel Burns, Anna Cuthbert
BACKGROUND: Water immersion during labour and birth is increasingly popular and is becoming widely accepted across many countries, and particularly in midwifery-led care settings. However, there are concerns around neonatal water inhalation, increased requirement for admission to neonatal intensive care unit (NICU), maternal and/or neonatal infection, and obstetric anal sphincter injuries (OASIS). This is an update of a review last published in 2011. OBJECTIVES: To assess the effects of water immersion during labour and/or birth (first, second and third stage of labour) on women and their infants...
May 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29766842/continuous-low-dose-antibiotic-prophylaxis-to-prevent-urinary-tract-infection-in-adults-who-perform-clean-intermittent-self-catheterisation-the-antic-rct
#15
Robert Pickard, Thomas Chadwick, Yemi Oluboyede, Catherine Brennand, Alexander von Wilamowitz-Moellendorff, Doreen McClurg, Jennifer Wilkinson, Laura Ternent, Holly Fisher, Katherine Walton, Elaine McColl, Luke Vale, Ruth Wood, Mohamed Abdel-Fattah, Paul Hilton, Mandy Fader, Simon Harrison, James Larcombe, Paul Little, Anthony Timoney, James N'Dow, Heather Armstrong, Nicola Morris, Kerry Walker, Nikesh Thiruchelvam
BACKGROUND: People carrying out clean intermittent self-catheterisation (CISC) to empty their bladder often suffer repeated urinary tract infections (UTIs). Continuous once-daily, low-dose antibiotic treatment (antibiotic prophylaxis) is commonly advised but knowledge of its effectiveness is lacking. OBJECTIVE: To assess the benefit, harms and cost-effectiveness of antibiotic prophylaxis to prevent UTIs in people who perform CISC. DESIGN: Parallel-group, open-label, patient-randomised 12-month trial of allocated intervention with 3-monthly follow-up...
May 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29766020/amelioration-of-muscle-and-nerve-pathology-in-lama2-muscular-dystrophy-by-aav9-mini-agrin
#16
Chunping Qiao, Yi Dai, Viktoriya D Nikolova, Quan Jin, Jianbin Li, Bin Xiao, Juan Li, Sheryl S Moy, Xiao Xiao
LAMA2-related muscular dystrophy (LAMA2 MD) is the most common and fatal form of early-onset congenital muscular dystrophies. Due to the large size of the laminin α2 cDNA and heterotrimeric structure of the protein, it is challenging to develop a gene-replacement therapy. Our group has developed a novel adeno-associated viral (AAV) vector carrying the mini-agrin, which is a non-homologous functional substitute for the mutated laminin α2. A significant therapeutic effect in skeletal muscle was observed in our previous study using AAV serotype 1 (AAV1)...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29765703/effects-of-baricitinib-on-radiographic-progression-of-structural-joint-damage-at-1-year-in-patients-with-rheumatoid-arthritis-and-an-inadequate-response-to-conventional-synthetic-disease-modifying-antirheumatic-drugs
#17
Desirée van der Heijde, Maxime Dougados, Ying-Chou Chen, Maria Greenwald, Edit Drescher, Rena Klar, Li Xie, Inmaculada de la Torre, Terence P Rooney, Sarah L Witt, Douglas E Schlichting, Stephanie de Bono, Paul Emery
Background: Baricitinib was efficacious in a 24-week phase III study in patients with rheumatoid arthritis (RA) and an inadequate response to conventional synthetic disease-modifying anti rheumatic drugs (DMARDs) (csDMARDs) (RA-BUILD). Objectives: To evaluate radiographic progression of structural joint damage in RA-BUILD patients over 48 weeks of baricitinib treatment in the long-term extension study, RA-BEYOND. Methods: In RA-BUILD, patients were randomised to placebo, baricitinib 2 mg or 4 mg once daily, with rescue possible from week 16...
2018: RMD Open
https://www.readbyqxmd.com/read/29765400/single-trial-evoked-potential-estimating-based-on-sparse-coding-under-impulsive-noise-environment
#18
Nannan Yu, Ying Chen, Lingling Wu, Hanbing Lu
Estimating single-trial evoked potentials (EPs) corrupted by the spontaneous electroencephalogram (EEG) can be regarded as signal denoising problem. Sparse coding has significant success in signal denoising and EPs have been proven to have strong sparsity over an appropriate dictionary. In sparse coding, the noise generally is considered to be a Gaussian random process. However, some studies have shown that the background noise in EPs may present an impulsive characteristic which is far from Gaussian but suitable to be modeled by the α -stable distribution (1 < α ≤ 2)...
2018: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/29765346/auditory-emotion-word-primes-influence-emotional-face-categorization-in-children-and-adults-but-not-vice-versa
#19
Michael Vesker, Daniela Bahn, Christina Kauschke, Monika Tschense, Franziska Degé, Gudrun Schwarzer
In order to assess how the perception of audible speech and facial expressions influence one another for the perception of emotions, and how this influence might change over the course of development, we conducted two cross-modal priming experiments with three age groups of children (6-, 9-, and 12-years old), as well as college-aged adults. In Experiment 1, 74 children and 24 adult participants were tasked with categorizing photographs of emotional faces as positive or negative as quickly as possible after being primed with emotion words presented via audio in valence-congruent and valence-incongruent trials...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29757971/comparison-of-the-conventional-and-electroenhanced-direct-immersion-solid-phase-microextraction-for-sampling-of-nicotine-in-biological-fluids-of-the-human-body
#20
Sana Abdolhosseini, Ali Reza Ghiasvand, Nahid Heidari
A stainless steel fiber was made porous and adhesive by platinization and then coated by nanostructured polypyrrole (PPy), using an appropriate electrophoretic deposition (EPD) method. The morphological surface structure and functional groups of the PPy-coated fiber were studied using SEM (Scanning electron microscope) instrument. The prepared fiber was used for comparison of direct immersion (DI) and electroenhanced direct immersion solid-phase microextraction (EE-DI-SPME) of nicotine in human plasma and urine samples followed by gas chromatography flame ionization detector (GC-FID) determination...
May 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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