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https://www.readbyqxmd.com/read/27913221/role-of-the-inflammasome-in-acetaminophen-induced-liver-injury-and-acute-liver-failure
#1
REVIEW
Benjamin L Woolbright, Hartmut Jaeschke
Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen overdose is the number one cause of acute liver failure and remains a major problem in Western medicine. Administration of N-acetyl cysteine is an effective antidote when given before the initial rise in toxicity; however, many patients present to the hospital after this stage occurs. As such, treatments which can alleviate late-stage acetaminophen-induced acute liver failure are imperative. While the initial mechanisms of toxicity are well described, a debate has occurred recently in the literature over whether or not there exists a second phase of injury, mediated by inflammatory processes...
November 29, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27911002/what-is-quality-of-life-and-how-do-we-measure-it-relevance-to-parkinson-s-disease-and-movement-disorders
#2
REVIEW
Pablo Martinez-Martin
Health-related quality of life is a patient-reported outcome that complements clinical evaluation and provides information about disease activity and effects of the treatment. The objective of this review is to present the conceptual framework, the measures, and some of their most relevant applications in the field of Parkinson's disease and movement disorders. Health-related quality of life is a subjective, individual, and multidimensional construct, and its main dimensions are physical, mental, and social, besides global perceptions of health and personal domains...
December 2, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27908047/assessing-the-perceptual-contributions-of-level-dependent-segments-to-sentence-intelligibility
#3
Tian Guan, Guang-Xing Chu, Yu Tsao, Fei Chen
The present work assessed the contributions of high root-mean-square (RMS) level (H-level, containing primarily vowels) and middle-RMS-level (M-level, with mostly consonants and vowel-consonant transitions) segments to the intelligibility of noise-masked and noise-suppressed sentences. In experiment 1, noise-masked (by speech-spectrum shaped noise and 6-talker babble) Mandarin sentences were edited to preserve only H- or M-level segments, while replacing the non-target segments with silence. In experiment 2, Mandarin sentences were subjected to four commonly-used single-channel noise-suppression algorithms before generating H-level-only and M-level-only noise-suppressed sentences...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27908000/on-synchronization-in-power-grids-modelled-as-networks-of-second-order-kuramoto-oscillators
#4
J M V Grzybowski, E E N Macau, T Yoneyama
This work concerns analytical results on the role of coupling strength in the phenomenon of onset of complete frequency locking in power-grids modelled as a network of second-order Kuramoto oscillators. Those results allow estimation of the coupling strength for the onset of complete frequency locking and to assess the features of network and oscillators that favor synchronization. The analytical results are evaluated using an order parameter defined as the normalized sum of absolute values of phase deviations of the oscillators over time...
November 2016: Chaos
https://www.readbyqxmd.com/read/27907840/clinical-68-ga-pet-is-radiosynthesis-module-an-absolute-necessity
#5
Rubel Chakravarty, Sudipta Chakraborty, E R Radhakrishnan, Koramadai Kamaleshwaran, Ajit Shinto, Ashutosh Dash
INTRODUCTION: The commercially available (68)Ge/(68)Ga generators are generally used in clinical context in conjunction with automated or semi-automated modules for the syntheses of (68)Ga radiopharmaceuticals. It is desirable to develop strategies for the formulation of (68)Ga-radiopharmaceuticals without use of such expensive modules in order to make (68)Ga-based clinical positron emission tomography (PET) more popular and affordable worldwide. METHODS: An organic matrix based (68)Ge/(68)Ga generator was used for preparation of clinically relevant doses of four different (68)Ga-based radiopharmaceuticals, namely (68)Ga-DOTA-NOC, (68)Ga-NODAGA-RGD2, (68)Ga-PSMA-11 and (68)Ga-BPAMD...
November 16, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27904531/effects-of-hyperbaric-oxygen-therapy-combined-with-platelet-rich-plasma-on-diabetic-wounds-an-experimental-rat-model
#6
Gündüz Yümün, Cüneyt Kahaman, Nail Kahaman, Ulviye Yalçınkaya, Aydin Akçılar, Engin Akgül, Ahmet Hakan Vural
INTRODUCTION: Hyperbaric oxygen and platelet-rich plasma are used in the treatment of diabetic wounds. The aim of this study is to evaluate the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing diabetic wounds. MATERIAL AND METHODS: Thirty-six female Wistar albino rats were used in this study. Diabetes mellitus was induced chemically with an intraperitoneal injection of streptozotocin. The rats were divided into a control group, a hyperbaric oxygen group, a platelet-rich plasma group, and a combined therapy group...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27903555/efficiency-of-hollow-fiber-liquid-phase-microextraction-chromatography-methods-in-the-separation-of-organic-compounds-a-review
#7
Ali Mohamed Ali Alsharif, Guan-Huat Tan, Yeun-Mun Choo, Abubakar Lawal
Hollow fiber liquid-phase microextraction (HF-LPME) techniques coupled to chromatographic systems have been widely used for extraction and determination of diverse compounds. HF-LPME was able to provide better results in precision, accuracy, selectivity and enrichment factor, in addition to reduction of matrix effect and carry over. It is applicable within a wide pH range and compatible with most analytical instruments which enable the utilization of HF-LPME in a wide variety of applications. This review focused on the modified HF-LPME techniques, efficiency, comparison to other LPME methods and applications...
November 29, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27902600/efficacy-and-safety-of-canagliflozin-in-patients-with-type-2-diabetes-a-meta-analysis-of-randomized-controlled-trials
#8
Wei Xiong, Ming Yue Xiao, Mei Zhang, Fei Chang
BACKGROUND: Canagliflozin is a new SGLT2 inhibitor which has been approved as an adjunct to diet and exercise for the treatment of adults with type 2 diabetes (T2D) mellitus in more than 30 countries. To evaluate the efficacy and safety of canagliflozin in patients with T2D, we carried out a meta-analysis of phase III clinical trials to offer an additional evidence of the efficacy and safety of canagliflozin for evidence-based clinical practice, strictly restricting the treatment durations to 26 weeks (core period) and 52 weeks (extension period)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27902429/plasmid-mediated-quinolone-resistance-determinants-among-gram-negative-bacteraemia-isolates-a-hidden-threat
#9
Athanasios Margaritis, Irene Galani, Marianthi Chatzikonstantinou, George Petrikkos, Maria Souli
The aim of the study was to investigate the prevalence of PMQR genes in an unselected collection of bloodstream isolates recovered over an 18-month period in a laboratory affiliated to a University Hospital in Athens, Greece and to assess their impact on the in vitro activity of ciprofloxacin and levofloxacin. Eight PMQR genes were screened by PCR and sequencing. All PMQR-positive isolates were submitted to isoelectric focusing for β-lactamase detection, conjugation or transformation, time-kill assays, MPC and inoculum effect evaluation...
November 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27900311/biological-enhancement-of-graft-tunnel-healing-in-anterior-cruciate-ligament-reconstruction
#10
Maristella F Saccomanno, Luigi Capasso, Luca Fresta, Giuseppe Milano
The sites where graft healing occurs within the bone tunnel and where the intra-articular ligamentization process takes place are the two most important sites of biological incorporation after anterior cruciate ligament (ACL) reconstruction, since they help to determine the mechanical behavior of the femur-ACL graft-tibia complex. Graft-tunnel healing is a complex process influenced by several factors, such as type of graft, preservation of remnants, bone quality, tunnel length and placement, fixation techniques and mechanical stress...
July 2016: Joints
https://www.readbyqxmd.com/read/27900215/drug-treatment-of-bothersome-lower-urinary-tract-symptoms-after-ureteric-jj-stent-insertion-a-contemporary-comparative-prospective-randomised-placebo-controlled-study-single-centre-experience
#11
Ihab A Hekal
OBJECTIVE: To provide a guide for medication to alleviate bothersome lower urinary tract symptoms (LUTS) in patients after JJ ureteric stenting. PATIENTS AND METHODS: Between June 2011 and June 2015, a prospective randomised placebo-controlled study was conducted on 200 consecutive cases of ureteric stones that required JJ stents. All patients had signed informed consent and JJ-stent placement confirmed by X-ray. The patients were randomised into five groups: A, solifenacin 5 mg; B, trospium chloride 20 mg; C, antispasmodic; and E, α-blocker; and a placebo group (D)...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27899894/moderate-load-eccentric-exercise-a-distinct-novel-training-modality
#12
REVIEW
Hans Hoppeler
Over the last 20 years a number of studies have been published using progressive eccentric exercise protocols on motorized ergometers or similar devices that allow for controlled application of eccentric loads. Exercise protocols ramp eccentric loads over an initial 3 weeks period in order to prevent muscle damage and delayed onset muscle soreness. Final training loads reach 400-500 W in rehabilitative settings and over 1200 W in elite athletes. Training is typically carried out three times per week for durations of 20-30 min...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27899264/cyclic-ferrocenylnaphthalene-diimide-derivative-as-a-new-class-of-g-quadruplex-dna-binding-ligand
#13
Md Monirul Islam, Shinobu Sato, Shingo Shinozaki, Shigeori Takenaka
To identify an effective ligand that binds to a G-quadruplex structure but not a double-stranded DNA (dsDNA), a set of biophysical and biochemical experiments were carried out using newly synthesized cyclic ferrocenylnaphthalene diimide (cFNDI, 1) or the non-cyclic derivative (2) with various structures of G-quadruplex DNAs and dsDNA. Compound 1 bound strongly to G-quadruplexes DNAs (10(6)M(-1) order) with diminished binding to dsDNA (10(4)M(-1) order) in 100mM AcOH-AcOK buffer (pH 5.5) containing 100mM KCl...
November 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27898900/effects-of-stocking-rate-forage-management-and-grazing-management-on-performance-and-economics-of-cow-calf-production-in-southwest-arkansas
#14
P A Beck, C B Stewart, M B Sims, M S Gadberry, J A Jennings
The objective this research was to determine the effect of application of multiple grazing management practices at 2 stocking rates (SR) on the productivity and economics of the cow-calf enterprise in the Southeastern United States over a 4-yr period. Pasture management systems included: continuous grazing management at a moderate SR (0.8 ha/cow; CG) without additional forage management, rotational grazing management at a moderate SR (0.8 ha/cow (MR) with addition of stockpiled bermudagrass [ (L.) Pers.] and complementary cool season annuals, and rotational grazing management similar to MR but with a high SR (0...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27895572/plastic-changes-in-human-motor-cortical-output-induced-by-random-but-not-closed-loop-peripheral-stimulation-the-curse-of-causality
#15
Kenneth I Brown, Elizabeth R Williams, Felipe de Carvalho, Stuart N Baker
Previous work showed that repetitive peripheral nerve stimulation can induce plastic changes in motor cortical output. Triggering electrical stimulation of central structures from natural activity can also generate plasticity. In this study, we tested whether triggering peripheral nerve stimulation from muscle activity would likewise induce changes in motor output. We developed a wearable electronic device capable of recording electromyogram (EMG) and delivering electrical stimulation under closed-loop control...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27895084/prescription-preferences-in-antipsychotics-and-attitude-towards-the-pharmaceutical-industry-in-belgium
#16
Stijn Cleymans, Manuel Morrens, Chris Bervoets
OBJECTIVES: The number of antipsychotic prescriptions are increasing rapidly worldwide, a trend which is mainly driven by the steep rise in second-generation antipsychotic (SGA) prescriptions. However, the success of SGA, compared with the older first-generation antipsychotics (FGAs), cannot be explained by evidence. Several studies concluded on equal efficacy of FGA and SGA on positive, negative and cognitive symptoms of schizophrenia. Next to that, the influence of the pharmaceutical industry on prescription behaviour has drawn considerable interest...
November 28, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27894613/comparative-study-between-thulium-laser-tm-yag-150w-and-greenlight-laser-lbo-nd-yag-120w-for-the-treatment-of-benign-prostatic-hyperpplasia-short-term-efficacy-and-security
#17
J L Palmero-Martí, J Panach-Navarrete, L Valls-González, A Ganau-Ituren, J Miralles-Aguado, A Benedicto-Redón
OBJECTIVE: To compare the results of efficacy and safety of Thulium laser 150W against Greenlight laser 120W in the treatment of short term benign prostatic hyperplasia (12 months after surgery). MATERIAL AND METHODS: This is a retrospective observational study where men who underwent the surgical technique of prostate vaporization over a period of four years in our center are included. The homogeneity of the sample was checked, and postoperative complications (acute urinary retention, reentry, need for transfusion), failures per year of surgery (reoperation, peak flow <15ml/sec, no improvement in comparing the I-PSS), and decreased PSA were compared a year after surgery...
November 25, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27894303/integrated-agriculture-programs-to-address-malnutrition-in-northern-malawi
#18
Rachel Bezner Kerr, Emmanuel Chilanga, Hanson Nyantakyi-Frimpong, Isaac Luginaah, Esther Lupafya
BACKGROUND: In countries where the majority of undernourished people are smallholder farmers, there has been interest in agricultural interventions to improve nutritional outcomes. Addressing gender inequality, however, is a key mechanism by which agriculture can improve nutrition, since women often play a crucial role in farming, food processing and child care, but have limited decision-making and control over agricultural resources. This study examines the approaches by which gender equity in agrarian, resource-poor settings can be improved using a case study in Malawi...
November 28, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27894269/prevalence-of-abdominal-aortic-aneurysms-and-its-relation-with-cardiovascular-risk-stratification-protocol-of-the-risk-of-cardiovascular-diseases-and-abdominal-aortic-aneurysm-in-varese-rocav-population-based-study
#19
F Gianfagna, G Veronesi, L Bertù, M Tozzi, A Tarallo, M M Ferrario, P Castelli
BACKGROUND: Recent meta-analyses suggested that screening program for abdominal aortic aneurysms (AAA) in 65-year old males is cost-effective at prevalence of about 1%. Since some events occur also in females and among the youngers, screening could be feasible among those at higher risk, such as smokers or individuals with a family history of AAA. The RoCAV (Risk of Cardiovascular diseases and abdominal aortic Aneurysms in Varese) Project is a population-based study aimed to evaluate AAA prevalence in Northern Italy in males over-65 years as well as among females and younger males, and to identify new markers for risk stratification by collecting a large set of CVD risk factors...
November 29, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27894231/evidence-of-exposure-to-cytostatic-drugs-in-healthcare-staff-a-review-of-recent-literature
#20
Pablo Martín Lancharro, Nuria De Castro-Acuña Iglesias, Francisco-Javier González-Barcala, José Domingo Moure González
OBJECTIVE: Provide updated evidence and learn about the actions that must be implemented in order to prevent the occupational exposure to cytostatic drugs. METHOD: A bibliographic search was carried out on the MEDLINE, COCHRANE PLUS and WEB OF SCIENCE databases, with the terms "surface contamination", "cytostatic drug", "drug preparation", "occupational exposure", "safe handling" and "closed-system transfer device", within the 2010-2015 period. RESULTS: Thirteen articles were selected for review...
November 1, 2016: Farmacia Hospitalaria
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