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Cancer autoantibody

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https://www.readbyqxmd.com/read/28105689/preferential-recognition-of-auto-antibodies-against-4-hydroxynonenal-modified-dna-in-the-cancer-patients
#1
Mohammad Faisal, Uzma Shahab, Abdulrahman A Alatar, Saheem Ahmad
BACKGROUND: The structural perturbations in DNA molecule may be caused by a break in a strand, a missing base from the backbone, or a chemically changed base. These alterations in DNA that occurs naturally can result from metabolic or hydrolytic processes. DNA damage plays a major role in the mutagenesis, carcinogenesis, aging and various other patho-physiological conditions. DNA damage can be induced through hydrolysis, exposure to reactive oxygen species (ROS) and other reactive carbonyl metabolites including 4-hydroxynonenal (HNE)...
January 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28099331/atorvastatin-induced-necrotizing-autoimmune-myositis-an-emerging-dominant-entity-in-patients-with-autoimmune-myositis-presenting-with-a-pure-polymyositis-phenotype
#2
Yves Troyanov, Océane Landon-Cardinal, Marvin J Fritzler, José Ferreira, Ira N Targoff, Eric Rich, Michelle Goulet, Jean-Richard Goulet, Josiane Bourré-Tessier, Yves Robitaille, Julie Drouin, Alexandra Albert, Jean-Luc Senécal
The general aim of this study was to evaluate the disease spectrum in patients presenting with a pure polymyositis (pPM) phenotype. Specific objectives were to characterize clinical features, autoantibodies (aAbs), and membrane attack complex (MAC) in muscle biopsies of patients with treatment-responsive, statin-exposed necrotizing autoimmune myositis (NAM). Patients from the Centre hospitalier de l'Université de Montréal autoimmune myositis (AIM) Cohort with a pPM phenotype, response to immunosuppression, and follow-up ≥3 years were included...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28074593/microtubule-associated-protein-map-1b-novel-paraneoplastic-biomarker-running-head-map-1b-igg-novel-paraneoplastic-biomarker
#3
Avi Gadoth, Thomas J Kryzer, Jim Fryer, Andrew McKeon, Vanda A Lennon, Sean J Pittock
To report the identification of microtubule associated protein (MAP)1B as the antigen of the previously described PCA-2 antibody, its frequency and clinical, oncological and serological associations. Methods Archival serum or cerebrospinal fluid (CSF) specimens were available from 96 of 118 consecutive PCA-2-IgG-seropositive patients identified 1993-2016. The autoantigen, defined in mouse brain lysate by western blot and mass spectrometry, was confirmed by dual immunohistochemical staining using commercial antibodies...
January 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28064445/a-panel-of-autoantibodies-against-multiple-tumor-associated-antigens-for-detecting-gastric-cancer
#4
Isamu Hoshino, Matsuo Nagata, Nobuhiro Takiguchi, Yoshihiro Nabeya, Atsushi Ikeda, Sana Yokoi, Akiko Kuwajima, Masatoshi Tagawa, Kazuyuki Matsushita, Yajima Satoshi, Shimada Hideaki
Gastric cancer is the second leading cause of cancer deaths in the world, and effective diagnosis is extremely important for good outcome. We assessed the diagnostic potential of an autoantibody panel that may provide a novel tool for the early detection of gastric cancer. We analyzed data from patients with gastric cancer and normal controls in a test and validation cohorts. Autoantibody levels were measured against a panel of six tumor-associated antigens [TAAs; p53, heat shock protein 70 (HSP70), HCC-22-5, peroxiredoxin VI (Prx VI), KM-HN-1, and p90 TAA (CYP2A)] via ELISA...
January 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/28063224/current-status-and-prospective-regarding-the-therapeutic-potential-of-natural-autoantibodies-in-cancer-therapy
#5
REVIEW
Salimeh Ebrahimnezhad, MirHadi Jazayeri, Seyed Mahdi Hassanian, Amir Avan
The presence of natural auto-antibodies (NAbs) in normal range/activity in healthy individuals is essential for body to maintain hemostasis, which are directed to self and altered self-components, while abnormal activity of this system can be associated with several health related diseases. It has been shown that NAbs regulate immune system, and can be changed during the individual's life. In other word, the level and pattern of Nabs is among the main factors to define the state of the body, suggesting their prognostic values as markers of immune system impairment such as autoimmunity and cancer...
January 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28062719/characteristics-in-limbic-encephalitis-with-anti-adenylate-kinase-5-autoantibodies
#6
Le-Duy Do, Eve Chanson, Virginie Desestret, Bastien Joubert, François Ducray, Sabine Brugière, Yohann Couté, Maité Formaglio, Veronique Rogemond, Catherine Thomas-Antérion, Laura Borrega, Brice Laurens, Francois Tison, Jonathan Curot, Thomas De Brouker, Christine Lebrun-Frenay, Jean-Yves Delattre, Jean-Christophe Antoine, Jerome Honnorat
OBJECTIVE: To report 10 patients with limbic encephalitis (LE) and adenylate kinase 5 autoantibodies (AK5-Abs). METHODS: We conducted a retrospective study in a cohort of 50 patients with LE with uncharacterized autoantibodies and identified a specific target using immunohistochemistry, Western blotting, immunoprecipitation, mass spectrometry, and cell-based assay. RESULTS: AK5 (a known autoantigen of LE) was identified as the target of antibodies in the CSFs and sera of 10 patients with LE (median age 64 years; range 57-80), which was characterized by subacute anterograde amnesia without seizure and sometimes preceded by a prodromal phase of asthenia or mood disturbances...
January 6, 2017: Neurology
https://www.readbyqxmd.com/read/28056690/2016-guidelines-of-the-american-thyroid-association-for-the-diagnosis-and-management-of-thyroid-disease-during-pregnancy-and-the-postpartum
#7
Erik K Alexander, Elizabeth N Pearce, Gregory A Brent, Rosalind S Brown, Herbert Chen, Chrysoula Dosiou, William Grobman, Peter Laurberg, John H Lazarus, Susan J Mandel, Robin Peeters, Scott Sullivan
BACKGROUND: Thyroid disease in pregnancy is a common clinical problem. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were first published in 2011, significant clinical and scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid disease in women during pregnancy, preconception and the postpartum period...
January 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28045754/anti-nxp2-positive-paraneoplastic-dermatomyositis-with-histopathologic-changes-confined-to-the-acrosyringia
#8
Jose Luis Ramírez-Bellver, Elena Macías, Claudia Bernárdez, Joaquín López-Robles, Maria Del Carmen Vegas-Sánchez, Jose Luis Díaz-Recuero, Hernán Quiceno, Luis Requena
BACKGROUND: Paraneoplastic syndromes consist of a group of disorders that are not related to the extension of the primary tumor or its metastases and that might be the first manifestation of a hidden neoplasm. It is a well-known association between dermatomyositis (DM) and cancer, especially gynecological tumors in women and lung cancer in men. METHODS: We describe the case of a 67-year-old male who developed muscular weakness and pruritic skin lesions. Skin biopsies were performed and histologic findings were consistent with DM...
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28024097/immunoglobulin-a-magic-bullet-or-trojan-horse
#9
REVIEW
Marieke H Heineke, Marjolein van Egmond
BACKGROUND: Neutrophils participate in the first line of defense by executing several killing mechanisms, including phagocytosis, degranulation and the release of neutrophil extracellular traps. Additionally, they can orchestrate the adaptive immune system by secreting cytokines and chemokines. Opsonization with antibodies aids in the recognition of pathogens, via binding to Fc receptors on the neutrophil surface. Immunoglobulin A (IgA) is the most abundant antibody at mucosal sites and has multiple functions in homeostasis and immunity...
December 26, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27983529/autoantibodies-against-heat-shock-proteins-as-biomarkers-for-the-diagnosis-and-prognosis-of-cancer
#10
Liu Shi, Yann Chevolot, Eliane Souteyrand, Emmanuelle Laurenceau
Thanks to their specificity and stability in the sera, autoantibodies (AAbs) against tumor-associated antigens (TAAs) are very attractive biomarkers for the development of less invasive serological tests for the diagnosis and prognosis of cancer. Heat shock proteins (HSP) belong to TAAs and they are over-expressed in various human cancers. Elevated HSP can stimulate the immune system to produce anti-HSP antibodies. So far, AAbs against HSP have been identified in the circulation of various cancer patients. Here we will review current literature on the use of anti-HSP antibodies for cancer diagnosis and prognosis...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27965399/selenium-binding-protein-1-autoantibodies-in-ovarian-disorders-and-ovarian-cancer
#11
Yi Yu-Rice, Seby L Edassery, Nicole Urban, Ingegerd Hellstrom, Karl Eric Hellstrom, Youping Deng, Yan Li, Judith Luborsky
Infertility is a risk factor for ovarian cancer (OvCa). The goal was to determine if antibodies to Selenium Binding Protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and OvCa patients, and thus could be associated with preneoplasia. Anti-SBP1 was measured by immunoassay against recombinant SBP1, in sera from OvCa (n=41), infertility (n=92) and control (n=87) patients. Infertility causes were POF, unexplained, irregular ovulation or endometriosis...
December 13, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27956255/tumor-associated-autoantibodies-against-fascin-as-a-novel-diagnostic-biomarker-for-esophageal-squamous-cell-carcinoma
#12
Wen-Xia Chen, Xin-Bin Hong, Chao-Qun Hong, Ming Liu, Lan Li, Li-Sheng Huang, Li-Yan Xu, Yi-Wei Xu, Yu-Hui Peng, En-Min Li
BACKGROUND AND OBJECTIVE: Autoantibodies against tumor-associated antigens (TAAs) have been found in many kinds of cancers, and might serve as biomarkers for early cancer diagnosis. The present study was carried out to test if there is any relation between autoantibodies against Fascin and esophageal squamous cell carcinoma (ESCC). METHODS: One hundred and forty-nine patients with ESCC and 98 control subjects were recruited in the study. The levels of circulating autoantibodies against Fascin were measured by enzyme-linked immunosorbent assay (ELISA)...
December 9, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27933384/thyroid-autoimmunity-is-really-associated-with-papillary-thyroid-carcinoma
#13
Alev Selek, Berrin Cetinarslan, Ilhan Tarkun, Zeynep Canturk, Berna Ustuner, Zeynep Akyay
The incidence of thyroid cancer has been greatly increasing. Several studies aimed to investigate biomarkers for prediction of thyroid cancer. Some of these studies have suggested that thyroid autoantibodies (TAb) could be used as predictors of thyroid cancer risk, but the correlation between TAb and PTC is still a matter of debate. The aim of this study is to evaluate thyroid autoimmunity and TAbs in patients with PTC and benign multinodular goiter (MNG) to investigate if TAbs and autoimmune thyroid disease (ATD) could predict thyroid malignancy...
December 8, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27923250/clinical-evaluation-of-the-first-automated-assay-for-the-detection-of-stimulating-tsh-receptor-autoantibodies
#14
S Allelein, M Ehlers, S Goretzki, D Hermsen, J Feldkamp, M Haase, T Dringenberg, C Schmid, H Hautzel, M Schott
Until recently, stimulating TSH receptor autoantibodies (sTRAbs) could only be measured by bioassays. A new assay system, which directly detects sTRAb in sera by applying bridge technology, has been established and is now available as automated chemiluminescence (bridge) immunoassay. We evaluated the automated bridge assay in clinical routine and compared it with a conventional automated TRAb assay (competition assay). Altogether, 226 Graves' disease (GD), 57 autoimmune thyroiditis, 74 non-autoimmune nodular goiter and 49 thyroid cancer patients, as well as 41 healthy controls were retrospectively evaluated...
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27922049/identification-of-kiaa1199-as-a-biomarker-for-pancreatic-intraepithelial-neoplasia
#15
Han Na Suh, Sohee Jun, Ah-Young Oh, Mrinal Srivastava, Sunhye Lee, Cullen M Taniguchi, Songlin Zhang, Won Sup Lee, Junjie Chen, Bum-Joon Park, Jae-Il Park
Pancreatic cancer is one of the most aggressive cancers and has an extremely poor prognosis. Despite recent progress in both basic and clinical research, most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific symptoms. Thus, developing novel approaches for detecting pancreatic cancer at an early stage is imperative. Our in silico and immunohistochemical analyses showed that KIAA1199 is specifically expressed in human pancreatic cancer cells and pancreatic intraepithelial neoplasia, the early lesion of pancreatic cancer, in a genetically engineered mouse model and in human patient samples...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896669/detection-of-autoantibodies-to-dsf70-ledgfp75-in-mexican-hispanics-using-multiple-complementary-assay-platforms
#16
Mónica Vázquez-Del Mercado, Eduardo Gómez-Bañuelos, Rosa Elena Navarro-Hernández, Oscar Pizano-Martinez, Adan Saldaña-Millán, Efrain Chavarria-Avila, Lorena Gonzalez-Rosas, Lilia Andrade-Ortega, Miguel Angel Saavedra, Olga Lidia Vera-Lastra, Luis Javier Jara, Gabriel Medrano-Ramírez, Claudia Cruz-Reyes, Ignacio García-De la Torre, Marta Escarra-Senmarti, Lisiane Maria Enriconi-Dos Anjos, Anamika Basu, Roger Albesa, Michael Mahler, Carlos A Casiano
PURPOSE: Antinuclear autoantibodies (ANA) targeting the dense fine speckled antigen DFS70, also known as lens epithelium-derived growth factor p75 (LEDGF/p75), are attracting attention due to their low frequency in systemic rheumatic diseases but increased frequency in clinical laboratory referrals and healthy individuals (HI). These ANA specifically recognize the stress protein DFS70/LEDGFp75, implicated in cancer, HIV-AIDS, and inflammation. While their frequency has been investigated in various ethnic populations, there is little information on their frequency among Hispanics/Latinos...
December 2017: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/27875523/a-protein-fragment-derived-from-dna-topoisomerase-i-as-a-novel-tumour-associated-antigen-for-the-detection-of-early-stage-carcinoma
#17
Shang-Mian Yie, Shang-Rong Ye, Xiao-Li Ma, Ke Xie, Jian-Bo Zhang, Mei Cao, Xu He, Zhen-Bo Hu, Cheng-Lu Yang, Jia Zhang, Jie Zeng
BACKGROUND: The production of autoantibodies against tumour-associated antigens (TAAs) is believed to reflect greater immunologic reactivity in cancer patients and enhanced immune surveillance for cancer cells. Over the past few decades, a number of different TAAs and their corresponding autoantibodies have been investigated. However, positive frequency of autoantibody detection in cancer patients has been relatively low. Here we describe a novel TAA that was a fragment derived from human DNA-topoiomerase I and an autoantibody against the novel TAA with relatively high positive frequency in the sera of early-stage non-small-cell lung cancer (NSCLC), gastric cancer (GC), colorectal cancer (CRC) and oesophageal squamous cell carcinoma (ESCC)...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27856749/in-vivo-amelioration-of-endogenous-antitumor-autoantibodies-via-low-dose-p4n-through-the-lta4h-activin-a-baff-pathway
#18
Yu-Ling Lin, Nu-Man Tsai, Cheng-Hao Hsieh, Shu-Yi Ho, Jung Chang, Hsin-Yi Wu, Ming-Hua Hsu, Chia-Ching Chang, Kuang-Wen Liao, Tiffany L B Jackson, David E Mold, Ru Chih C Huang
Cancer progression is associated with the development of antitumor autoantibodies in patients' sera. Although passive treatment with antitumor antibodies has exhibited remarkable therapeutic efficacy, inhibitory effects on tumor progression by endogenous antitumor autoantibodies (EAAs) have been limited. In this study, we show that P4N, a derivative of the plant lignan nordihydroguaiaretic acid (NDGA), enhanced the production of EAAs and inhibited tumor growth at low noncytotoxic concentrations via its immunoregulatory activity...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27847402/autoantibody-response-to-zrf1-and-krr1-serex-antigens-in-patients-with-breast-tumors-of-different-histological-types-and-grades
#19
Lada Dyachenko, Kristina Havrysh, Anita Lytovchenko, Irina Dosenko, Stepan Antoniuk, Valeriy Filonenko, Ramziya Kiyamova
Purpose. To investigate a frequency of antibody response to SEREX-identified medullary breast carcinoma autoantigens ZRF1 and KRR1 in sera of breast cancer patients taking into account clinical and molecular characteristics of tumors for opening of new perspectives in creation of minimally invasive immunological tests for cancer diagnostics. Methods. Enzyme-linked immunosorbent assay and bioinformatics analysis. Results. Increased frequency of antibody response was found in sera of breast cancer patients to ZRF and KRR1 antigens...
2016: Disease Markers
https://www.readbyqxmd.com/read/27821747/systematic-autoantigen-analysis-identifies-a-distinct-subtype-of-scleroderma-with-coincident-cancer
#20
George J Xu, Ami A Shah, Mamie Z Li, Qikai Xu, Antony Rosen, Livia Casciola-Rosen, Stephen J Elledge
Scleroderma is a chronic autoimmune rheumatic disease associated with widespread tissue fibrosis and vasculopathy. Approximately two-thirds of all patients with scleroderma present with three dominant autoantibody subsets. Here, we used a pair of complementary high-throughput methods for antibody epitope discovery to examine patients with scleroderma with or without known autoantibody specificities. We identified a specificity for the minor spliceosome complex containing RNA Binding Region (RNP1, RNA recognition motif) Containing 3 (RNPC3) that is found in patients with scleroderma without known specificities and is absent in unrelated autoimmune diseases...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
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