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CT Colonography

Mitsutoshi Miyasaka, Daisuke Tsurumaru, Yusuke Nishimuta, Yoshiki Asayama, Satoshi Kawanami, Eiji Oki, Minako Hirahashi, Hiroshi Honda
OBJECTIVE: To investigate the feasibility of diagnosing the invasion depth of early colorectal cancer (CRC) by quantitatively evaluating the basal indentation (BI)-i.e., the intestinal lateral deformity-in CT colonography (CTC). MATERIALS AND METHODS: 34 early CRCs (13 Tis CRCs and 21 T1 CRCs) in 32 patients who underwent a preoperative CTC were retrospectively examined. Two radiologists calculated the depth of the BI on a computed tomographic air-contrast enema (CT enema) image, the depth of the BI due to the geometric function (BI-G) on a cross-sectional multiplanar reconstruction (CS-MPR) image, and the ratio of the BI to the BI-G (i...
October 7, 2016: Japanese Journal of Radiology
Elizabeth Sheena John, Ann M John, David R Hansberry, Prashant J Thomas, Prateek Agarwal, Christopher Deitch, Sita Chokhavatia
PURPOSE: Patients screened for colorectal cancer (CRC) frequently turn to the Internet to improve their understanding of tests used for detection, including colonoscopy, flexible sigmoidoscopy, fecal occult blood test (FOBT), and CT colonography. It was of interest to determine the quality and readability levels of online health information. METHODS: The screening tools were googled, and the top 20 results of each test were analyzed for readability, accessibility, usability, and reliability...
September 20, 2016: International Journal of Colorectal Disease
Chelsie K Sievers, Luli S Zou, Perry J Pickhardt, Kristina A Matkowskyj, Dawn M Albrecht, Linda Clipson, Jeffery W Bacher, B Dustin Pooler, Fouad J Moawad, Brooks D Cash, Mark Reichelderfer, Tien N Vo, Michael A Newton, Bret R Larget, Richard B Halberg
OBJECTIVE AND DESIGN: The goal of the study was to determine whether the mutational profile of early colorectal polyps correlated with growth behaviour. The growth of small polyps (6-9 mm) that were first identified during routine screening of patients was monitored over time by interval imaging with CT colonography. Mutations in these lesions with known growth rates were identified by targeted next-generation sequencing. The timing of mutational events was estimated using computer modelling and statistical inference considering several parameters including allele frequency and fitness...
September 8, 2016: Gut
Kenichi Utano, Koichi Nagata, Tetsuro Honda, Toru Mitsushima, Takaaki Yasuda, Takashi Kato, Shoichi Horita, Michio Asano, Noritaka Oda, Kenichiro Majima, Yasutaka Kawamura, Michiaki Hirayama, Naoki Watanabe, Hidenori Kanazawa, Alan Kawarai Lefor, Hideharu Sugimoto
Purpose To evaluate the diagnostic accuracy and patient acceptance of reduced-laxative computed tomographic (CT) colonography without computer-aided detection (CAD) for the detection of colorectal polypoid and non-polypoid neoplasms in a population with a positive recent fecal immunochemical test (FIT). Materials and Methods Institutional review board approval and written informed consent were obtained. This multicenter prospective trial enrolled patients who had positive FIT results. Reduced-laxative CT colonography and colonoscopy were performed on the same day...
August 31, 2016: Radiology
Perry J Pickhardt, B Dustin Pooler, Ifeanyi Mbah, Jennifer M Weiss, David H Kim
Purpose To determine the rate and types of polyps detected at repeat computed tomographic (CT) colonography screening after initial negative findings at CT colonography screening. Materials and Methods Among 5640 negative CT colonography screenings (no polyps ≥ 6 mm) performed before 2010 at one medical center, 1429 (25.3%; mean age, 61.4 years; 736 women, 693 men) patients have returned for repeat CT colonography screening (mean interval, 5.7 years ± 0.9; range, 4.5-10.7 years). Positive rates and histologic findings of initial and repeat screening were compared in this HIPAA-compliant, institutional review board-approved study...
August 22, 2016: Radiology
Lapo Sali, Daniele Regge
CT colonography (CTC) is a minimally invasive radiological investigation of the colon. Robust evidence indicates that CTC is safe, well tolerated and highly accurate for the detection of colorectal cancer (CRC) and large polyps, which are the targets of screening. Randomised controlled trials were carried out in Europe to evaluate CTC as primary test for population screening of CRC in comparison with faecal immunochemical test (FIT), sigmoidoscopy and colonoscopy. Main outcomes were participation rate and detection rate...
August 19, 2016: British Journal of Radiology
Gerritt M Lagemann, Patrick W Aldred, Amir A Borhani, Anish Ghodadra, Vikas Agarwal
OBJECTIVE: Planning imaging performed during CT-guided procedures may occasionally contain important incidental findings. The purpose of this study was to identify and characterize by clinical relevance the extraspinal findings detected on planning imaging for CT-guided lumbar transforaminal epidural steroid injections (TFESIs). MATERIALS AND METHODS: Four radiologists retrospectively evaluated the planning scout views and CT studies for 488 consecutive CT-guided lumbar TFESIs performed in 400 patients over a 1-year period...
August 17, 2016: AJR. American Journal of Roentgenology
B Dustin Pooler, David H Kim, Perry J Pickhardt
OBJECTIVE: The purpose of this study was to analyze the incidence and outcomes of unsuspected indeterminate but likely unimportant extracolonic findings (CT Colonography Reporting and Data System [C-RADS] category E3) at screening CT colonography (CTC). MATERIALS AND METHODS: Over 99 months (April 2004 through June 2012), 7952 consecutive adults without symptoms of colorectal cancer (4277 women, 3675 men; mean age ± SD, 56.7 ± 7.3 years) underwent first-time screening CTC...
November 2016: AJR. American Journal of Roentgenology
Elias Nerad, Max J Lahaye, Monique Maas, Patty Nelemans, Frans C H Bakers, Geerard L Beets, Regina G H Beets-Tan
OBJECTIVE: The purpose of this article is to determine the accuracy of CT in the detection of tumor invasion beyond the bowel wall and nodal involvement of colon carcinomas. A literature search was performed to identify studies describing the accuracy of CT in the staging of colon carcinomas. Studies including rectal carcinomas that were inseparable from colon carcinomas were excluded. Publication bias was explored by using a Deeks funnel plot asymmetry test. A hierarchic summary ROC model was used to construct a summary ROC curve and to calculate summary estimates of sensitivity, specificity, and diagnostic odds ratios (ORs)...
November 2016: AJR. American Journal of Roentgenology
Prasanna L Ponugoti, Oscar W Cummings, Douglas K Rex
The prevalence of cancer in small and diminutive polyps is relevant to "resect and discard" and CT colonography reporting recommendations. We evaluated a prospectively collected colonoscopy polyp database to identify polyps <10mm and those with cancer or advanced histology (high-grade dysplasia or villous elements). Of 32,790 colonoscopies, 15,558 colonoscopies detected 42,630 polyps <10mm in size. A total of 4790 lesions were excluded as they were not conventional adenomas or serrated class lesions. There were 23,524 conventional adenomas <10mm of which 22,952 were tubular adenomas...
June 28, 2016: Digestive and Liver Disease
Masahiro Oda, Hiroaki Kondo, Takayuki Kitasaka, Kazuhiro Furukawa, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto, Nassir Navab, Kensaku Mori
PURPOSE: Polyps found during CT colonography can be removed by colonoscopic polypectomy. A colonoscope navigation system that navigates a physician to polyp positions while performing the colonoscopic polypectomy is required. Colonoscope tracking methods are essential for implementing colonoscope navigation systems. Previous colonoscope tracking methods have failed when the colon deforms during colonoscope insertions. This paper proposes a colonoscope tracking method that is robust against colon deformations...
July 18, 2016: International Journal of Computer Assisted Radiology and Surgery
David H Kim, Kristina A Matkowskyj, Perry J Pickhardt
No abstract text is available yet for this article.
August 2016: Abdominal Radiology
Michael P Achiam, Jakob Kjellberg, Jacob Rosenberg
BACKGROUND: Colorectal cancer is a frequent type of cancer, and with the risk of synchronous disease, the need for a complete staging leads to an extensive and costly preoperative diagnostic evaluation. Previously we described a total preoperative evaluation using magnetic resonance (MR) colonography and diffusion-weighted MR of the liver. PURPOSE: To compare the economic aspects of this modality with the standard evaluation in an analysis of the different cost drivers...
June 15, 2016: Acta Radiologica
Charles N Weber, Anna S Lev-Toaff, Marc S Levine, Sandra Sudarsky, Lutz Guendel, Bernhard Geiger, Hanna M Zafar
The aim of this study was to evaluate feasibility and reproducibility of quantitative assessment of colonic morphology on CT colonography (CTC). CTC datasets from 60 patients with optimal colonic distension were assessed using prototype software. Metrics potentially associated with poor endoscopic performance were calculated for the total colon and each segment including: length, volume, tortuosity (number of high curvature points <90°), and compactness (volume of box containing centerline divided by centerline length)...
June 11, 2016: Medical & Biological Engineering & Computing
Judy Yee, Kevin J Chang, Abraham H Dachman, David H Kim, Elizabeth G McFarland, Perry J Pickhardt, Brooks D Cash, David H Bruining, Michael E Zalis
No abstract text is available yet for this article.
August 2016: Journal of the American College of Radiology: JACR
Perry J Pickhardt
Colorectal cancer (CRC) screening can be undertaken utilizing a variety of distinct approaches, which provides both opportunities and confusion. Traditionally, there has often been a trade-off between the degree of invasiveness of a screening test and its ability to prevent cancer, with fecal occult blood testing (FOBT) and optical colonoscopy (OC) at each end of the spectrum. CT colonography (CTC), although currently underutilized for CRC screening, represents an exception since it is only minimally invasive, yet provides accurate evaluation for advanced adenomas...
August 2016: Abdominal Radiology
D Fuster, M Pagès, U Granados, P Perlaza, D Rubello, F Lomeña
No abstract text is available yet for this article.
July 2016: Revista Española de Medicina Nuclear e Imagen Molecular
N Maggialetti, R Capasso, D Pinto, M Carbone, A Laporta, S Schipani, C L Piccolo, M Zappia, A Reginelli, M D'Innocenzo, L Brunese
INTRODUCTION: This study evaluated the role of computed tomography colonography (CTC) in patients who previously underwent incomplete optical colonoscopy (OC). We analyzed the impact of colonic lesions in intestinal segments not studied by OC and extracolonic findings in these patients. METHODS: Between January 2014 and May 2015, 61 patients with a history of abdominal pain and incomplete OC examination were studied by CTC. CTCs were performed by 320-row CT scan in both the supine and the prone position, without intravenous administration of contrast medium...
September 2016: International Journal of Surgery
Paola Scalise, Annalisa Mantarro, Francesca Pancrazi, Emanuele Neri
Colorectal cancer (CRC) represents one of the most relevant causes of morbidity and mortality in Western societies. CRC screening is actually based on faecal occult blood testing, and optical colonoscopy still remains the gold standard screening test for cancer detection. However, computed tomography colonography (CT colonography) constitutes a reliable, minimally-invasive method to rapidly and effectively evaluate the entire colon for clinically relevant lesions. Furthermore, even if the benefits of its employment in CRC mass screening have not fully established yet, CT colonography may represent a reasonable alternative screening test in patients who cannot undergo or refuse colonoscopy...
May 28, 2016: World Journal of Radiology
Kazuhito Sato, Toshiaki Tanaka, Jiro Sato, Eisuke Shibata, Yuzo Nagai, Koji Murono, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Junichiro Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Shinsuke Kazama, Hironori Yamaguchi, Soichiro Ishihara, Eiji Sunami, Joji Kitayama, Kuni Ohtomo, Toshiaki Watanabe
BACKGROUND: Computed tomographic colonography (CTC) is reported to be feasible for screening of colorectal polyps; however, its efficacy in preoperative workup remains unknown. This study was done to define our CTC methodology and assess CTC's potential for preoperative examination in patients with colon cancer. METHODS: A total of 86 colon cancer patients underwent CTC prior to laparoscopic colectomy in our department from February 2014 to November 2015. The location of primary colon cancer determined by CTC was compared with that confirmed during the surgery...
May 20, 2016: Asian Journal of Surgery
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