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https://www.readbyqxmd.com/read/29684930/-prevention-and-detection-of-multidrug-resistant-bacteria
#1
Simone Scheithauer, Martin Kaase
Patients colonized or infected by multidrug-resistant bacteria (MDR) are entitled to the same medical treatment as other patients and infection control measures based on the current evidence are not in conflict with this aim. Recent studies indicate that the correct sampling technique is of utmost importance when screening for MRSA and usage of certain swabs might reduce the sensitivity considerably. Despite improvements in diagnostic strategies for direct MRSA detection by PCR, false positive results cannot be totally excluded...
May 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29684911/high-throughput-simultaneous-quantitation-of-hemoglobin-adducts-of-acrylamide-glycidamide-and-ethylene-oxide-using-uhplc-ms-ms
#2
Min Yang, Tunde Frame, Chui Tse, Hubert W Vesper
Ethylene oxide (EO), acrylamide (AA) and glycidamide (GA) exposures are associated with mammary tumors in animals. Currently available information about human exposure to these chemicals is limited creating the need for analytical methods to assess their exposure. We developed a sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method to simultaneously quantitate hemoglobin (Hb) N-terminal valine adducts of AA (HbAA), GA (HbGA), and EO (HbEO) using modified Edman reaction...
April 3, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29684908/chemometrics-assisted-investigation-of-interactions-of-tasmar-with-human-serum-albumin-at-a-glassy-carbon-disk-application-to-electrochemical-biosensing-of-electro-inactive-serum-albumin
#3
Ghobad Mohammadi, Elahe Faramarzi, Majid Mahmoudi, Sirous Ghobadi, Ali Reza Ghiasvand, Hector C Goicoechea, Ali R Jalalvand
In this work, voltammetric data recorded by a glassy carbon electrode (GCE) was used to investigate the interactions of tolcapone (Tasmar, TAS) with human serum albumin (HSA) at the electrode surface. The recorded voltammetric data was also combined with spectroscopic data to construct an augmented data matrix which was analysed by multivariate curve resolution-alternating least squares (MCR-ALS) as an efficient chemometric tool to obtain more information about TAS-HSA interactions. The results of MCR-ALS confirmed formation of one complex species (HSA-TAS2 ) and application of MCR-BANDS to the results of MCR-ALS confirmed the absence of rotational ambiguities and existing unambiguous and reliable results...
April 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684904/excess-hospitalization-expenses-attributable-to-type-2-diabetes-mellitus-in-singapore
#4
May Ee Png, Joanne Yoong, Chuen Seng Tan, Kee Seng Chia
OBJECTIVES: To estimate the excess hospitalization expenses attributable to type 2 diabetes mellitus (T2DM) in a high-income Asian country from the health system perspective and the patient perspective. METHODS: Electronic medical records from a tertiary academic hospital in Singapore from 2012 to 2013 were used to create propensity score-matched cohorts with and without T2DM on the basis of their entry characteristics. A two-part model was then used to control for remaining differences between the cohorts...
April 20, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29684893/comparison-of-the-moca-and-bearni-tests-for-detection-of-cognitive-impairment-in-in-patients-with-alcohol-use-disorders
#5
Stéphanie Pelletier, Régis Alarcon, Valérie Ewert, Margot Forest, Bertrand Nalpas, Pascal Perney
INTRODUCTION: Screening of cognitive impairment is a major challenge in alcoholics seeking treatment, since cognitive dysfunction may impair the overall efficacy of rehabilitation programs and consequently increase relapse rate. We compared the performance of two screening tools: the MoCA (Montreal Cognitive Assessment), which is widely used in patients with neurological diseases and already used in patients with alcohol use disorder (AUD), and the BEARNI (Brief Evaluation of Alcohol-Related Neuropsychological Impairments), a recent test specifically developed for the alcoholic population...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29684853/naringenin-improve-hepatitis-c-virus-infection-induced-insulin-resistance-by-increase-pten-expression-via-p53-dependent-manner
#6
Benli Jia, Dongsheng Yu, Gang Yu, Yunsheng Cheng, Yang Wang, Xiaoqiang Yi, Xiaoping Li, Yong Wang
Hepatitis C virus (HCV) infection may finally lead to hepatocellular carcinoma (HCC), and also associated with insulin resistance (IR). Naringenin (NGEN), a flavonoid found in grapefruit, has anti-virus, anti-inflammation and insulin sensitization effects. In the present study we examined the effects of NGEN on HCV core protein (HCVCP) infection induced IR and investigated the mechanism involved. We found that NGEN ameliorated IR and glucose tolerance in HCVCP infected mice by increase the phosphorylation of Akt at both Ser473 and Thr308 site, and also inhibited the inflammation cytokine production and T-cell immune response...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684847/the-association-between-p53-protein-phosphorylation-at-serine-15-serine-20-and-sensitivity-of-cells-isolated-from-patients-with-ovarian-cancer-and-cell-lines-to-chemotherapy-in-in-vitro-study
#7
Iwona Kamińska, Julia K Bar
BACKGROUND: The association between p53 protein phosphorylated at serine 15 (Ser15), serine 20 (Ser20) and ovarian tumor cell sensitivity after chemotherapy was analyzed in order to define the influence of p53 activation on tumor cell sensitivity to chemotherapy. METHODS: The study was performed on ovarian cancer cell line (OvBH-1), colon adenocarcinoma metastasis to ovary (SW626) and on cells isolated from ascitic fluids from patients with ovarian cancer: with (p53+) or without (p53-) p53 nuclear protein accumulation...
December 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29684842/shear-force-analysis-by-core-location-in-longissimus-steaks-from-nellore-cattle-using-hyperspectral-images-a-feasibility-study
#8
Juliana Monteiro Balage, José Manuel Amigo, Daniel Silva Antonelo, Madeline Rezende Mazon, Saulo da Luz E Silva
Industry requires non-destructive real-time methods for quality control of meat in order to improve production efficiency and meet consumer expectations. Near Infrared Hyperspectral Images were used for tenderness evaluation of Nellore beef and the construction of tenderness distribution maps. To investigate whether the selection of the region of interest (ROI) in the image at the exact location where the shear force core was collected improves tenderness prediction and classification models, 50 samples from Longissimus muscle were imaged (1000-2500 nm) and shear force were measured (Warner-Bratzler)...
April 12, 2018: Meat Science
https://www.readbyqxmd.com/read/29684829/the-effect-of-a-training-programme-on-school-nurses-knowledge-attitudes-and-depression-recognition-skills-the-quest-cluster-randomised-controlled-trial
#9
Mark Haddad, Vanessa Pinfold, Tamsin Ford, Brendan Walsh, Andre Tylee
BACKGROUND: Mental health problems in children and young people are a vital public health issue. Only 25% of British school children with diagnosed mental health problems have specialist mental health services contact; front-line staff such as school nurses play a vital role in identifying and managing these problems, and accessing additional services for children, but there appears limited specific training and support for this aspect of their role. OBJECTIVES: To evaluate the effectiveness of a bespoke short training programme, which incorporated interactive and didactic teaching with printed and electronic resources...
April 5, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29684819/protein-and-cell-wall-polysaccharide-carbonyl-determination-by-a-neutral-ph-2-4-dinitrophenylhydrazine-based-photometric-assay
#10
Christos D Georgiou, Dimitrios Zisimopoulos, Vasiliki Argyropoulou, Electra Kalaitzopoulou, George Salachas, Tilman Grune
A new 2,4-dinitrophenylhydrazine (DNPH)-based photometric assay is developed for the quantification of carbonyls in protein samples from any biological source by protein carbonyl-DNPH hydrazone formation at acidic pH in the presence of denaturing urea, and subsequent hydrazone solubilization in the presence of SDS and stabilization from acid hydrolysis at pH 7.0. At this neutral (ntr) pH, interfering unreacted DNPH is uncharged and its thus increased hydrophobicity permits its 100% effective removal from the solubilizate with ethyl acetate/hexane wash...
April 10, 2018: Redox Biology
https://www.readbyqxmd.com/read/29684818/glut1-protects-prostate-cancer-cells-from-glucose-deprivation-induced-oxidative-stress
#11
Pedro Gonzalez-Menendez, David Hevia, Rebeca Alonso-Arias, Alejandro Alvarez-Artime, Aida Rodriguez-Garcia, Sandrina Kinet, Ivan Gonzalez-Pola, Naomi Taylor, Juan C Mayo, Rosa M Sainz
Glucose, chief metabolic support for cancer cell survival and growth, is mainly imported into cells by facilitated glucose transporters (GLUTs). The increase in glucose uptake along with tumor progression is due to an increment of facilitative glucose transporters as GLUT1. GLUT1 prevents cell death of cancer cells caused by growth factors deprivation, but there is scarce information about its role on the damage caused by glucose deprivation, which usually occurs within the core of a growing tumor. In prostate cancer (PCa), GLUT1 is found in the most aggressive tumors, and it is regulated by androgens...
April 12, 2018: Redox Biology
https://www.readbyqxmd.com/read/29684813/metabolite-characterization-of-ambrisentan-in-in-vitro-and-in-vivo-matrices-by-uhplc-qtof-ms-ms-detection-of-glutathione-conjugate-of-epoxide-metabolite-evidenced-by-in-vitro-gsh-trapping-assay
#12
P Johnsi Rani, Chiguru Vishnuvardhan, Rakesh D Nimbalkar, Prabha Garg, N Satheeshkumar
The focus of the present study is on in vitro and in vivo metabolite identification of ambrisentan (AMBR) a selective endothelin type - A (ETA) receptor antagonist using quadruple time-of-flight mass spectrometry (QTOF/MS). in vitro metabolism study was conducted by incubating AMBR in rat liver microsomes (RLM), rat and human liver S9 fractions. In vivo study was carried out through the collection of urine, faeces and plasma samples at various time points after oral administration of AMBR in suspension form at a dose of 25 mg/kg to six male Sprague - Dawley (SD) rats...
April 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684758/non-enzymatic-sensing-of-glucose-using-screen-printed-electrode-modified-with-novel-synthesized-ceo-2-cuo-core-shell-nanostructure
#13
Dayakar T, K Venkateswara Rao, K Bikshalu, V Malapati, Kishor Kumar Sadasivuni
We fabricated a fourth generation glucose biosensor using CeO2 @CuO core shell nano structure (CeCCS NSs). A simple leave extract of Ocimum tenuiflorum was used to prepare different wt% of 0.2, 04, 0.6, and 0.8 CuO (shell), above 1 wt% of CeO2 (core). The successful formation was confirmed by various characterization techniques like XRD, Uv-Vis, FTIR, SEM and HR-TEM. In the biosensor, 0.4 wt% of CeCCS NSs has shown efficient properties due to its high surface area. The good conductivity and high catalytic activity towards glucose sensing properties were estimated by screen-printed electrode (SPE)...
April 5, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29684748/silk-fibroin-as-a-platform-for-dual-sensing-of-vitamin-b-12-using-photoluminescence-and-electrical-techniques
#14
Sudesna Chakravarty, Bedanta Gogoi, Biman B Mandal, Nandana Bhardwaj, Neelotpal Sen Sarma
The amalgamation of natural origin materials and technologies for label-free and real time detection is pertinent in analytical field. In this study, Bombyx mori silk fibroin protein (BMSF) has been utilized for the dual sensing of vitamin B12 via fluorescence and electrical impedance techniques. The processing of BMSF is done to generate an aqueous solution of BMSF along with the development of micro patterned thin films via soft lithography technique. The BMSF aqueous solution exhibit auto fluorescence property and thereby utilized for label free detection of vitamin B12 with an estimated limit of detection (LOD) of about 0...
March 28, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29684747/the-possible-dna-damage-induced-by-environmental-organic-compounds-the-case-of-nonylphenol
#15
REVIEW
Zahra Noorimotlagh, Seyyed Abbas Mirzaee, Mehdi Ahmadi, Neemat Jaafarzadeh, Fakher Rahim
Human impact on the environment leads to the release of many pollutants that produce artificial compounds, which can have harmful effects on the body's endocrine system; these are known as endocrine disruptors (EDs). Nonylphenol (NP) is a chemical compound with a nonyl group that is attached to a phenol ring. NP-induced H2 AX is a sensitive genotoxic biomarker for detecting possible DNA damage; it also causes male infertility and carcinogenesis. We attempt to comprehensively review all the available evidence about the different ways with descriptive mechanisms for explaining the possible DNA damage that is induced by NP...
April 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29684744/the-role-of-circulating-tumour-cells-and-nucleic-acids-in-blood-for-the-detection-of-bladder-cancer-a-systematic-review
#16
REVIEW
Pramit Khetrapal, Matthew Wei Liang Lee, Wei Shen Tan, Liqin Dong, Patricia de Winter, Andrew Feber, John D Kelly
BACKGROUND: Blood-based biomarkers are a neglected resource in bladder cancer, where the mainstay of focus has been on urinary biomarkers. However, blood-based biomarkers are gaining popularity in other solid cancers, particularly circulating tumour cells (CTCs) and circulating nucleic acids. In this systematic review, we identify and discuss the diagnostic value of CTC, cell-free DNA and RNA based biomarkers in bladder cancer. METHODS: A MEDLINE/Pubmed systematic search was performed using the following keywords: (bladder cancer) AND (blood OR plasma OR serum) AND biomarker AND (DNA OR RNA OR cfDNA OR cell-free DNA OR RNA OR CTC)...
April 17, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29684721/oocyte-atresia-in-wt-hdrr-and-p53-medaka-oryzias-latipes-exposed-to-uva
#17
A H Sayed, Rania F Ismail, Hiroshi Mitani
The negative effects of ambient ultraviolet (UVA) on the water environment have been recently highlighted; UVA can create deleterious effects by stimulating stress on pelagic organisms. Little is known about UVA effects on oocyte characteristics of female fish. In the present study we explored the effects of exposure to ecologically relevant levels of simulated UVA radiation on ovaries of two major strains WT (HdrR) and P53 (-/-) of medaka (Oryzias latipes) mature female. Fish were assigned to control and three UVA-exposed groups as (15 min, 30 min, and 60 min/day) for three days and sample selection was 24 h and 14 days after exposure...
April 12, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29684719/interhelical-interactions-between-d92-and-c218-in-the-cytoplasmic-domain-regulate-proton-uptake-upon-n-decay-in-the-proton-transport-of-acetabularia-rhodopsin-ii
#18
Jun Tamogami, Takashi Kikukawa, Keisuke Ohkawa, Noboru Ohsawa, Toshifumi Nara, Makoto Demura, Seiji Miyauchi, Tomomi Kimura-Someya, Mikako Shirouzu, Shigeyuki Yokoyama, Kazumi Shimono, Naoki Kamo
Acetabularia rhodopsin II (ARII or Ace2), an outward light-driven algal proton pump found in the giant unicellular marine alga Acetabularia acetabulum, has a unique property in the cytoplasmic (CP) side of its channel. The X-ray crystal structure of ARII in a dark state suggested the formation of an interhelical hydrogen bond between C218ARII and D92ARII , an internal proton donor to the Schiff base (Wada et al., 2011). In this report, we investigated the photocycles of two mutants at position C218ARII : C218AARII which disrupts the interaction with D92ARII , and C218SARII which potentially forms a stronger hydrogen bond...
April 11, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29684678/hydrogen-bonds-autonomously-powered-gelatin-methacrylate-hydrogels-with-super-elasticity-self-heal-and-underwater-self-adhesion-for-sutureless-skin-and-stomach-surgery-and-e-skin
#19
Bingcheng Liu, Ying Wang, Yong Miao, Xinyu Zhang, Zhexiang Fan, Gurankit Singh, Xingying Zhang, Kaige Xu, Bingyun Li, Zhiqi Hu, Malcolm Xing
Interface-interaction induced self-healing and self-adhesive are a gem-like attribute inspired by our Mother Nature. Biocompatible gelatin methacrylate (GelMA) hydrogels exhibit tunable mechanical properties which are favorable in biomedical applications. However, it is difficult to integrate high stiffness, super-elasticity, large deformability and self-healing property together. Here, we report a GelMA-based double-network (DN) hydrogel with above properties by utilizing tannic acid (TA) as a multi-functional H-bond provider...
April 15, 2018: Biomaterials
https://www.readbyqxmd.com/read/29684659/anxiety-sensitivity-and-suicide-risk-among-firefighters-a-test-of-the-depression-distress-amplification-model
#20
Ian H Stanley, Lia J Smith, Joseph W Boffa, Jana K Tran, N Brad Schmidt, Thomas E Joiner, Anka A Vujanovic
BACKGROUND: Firefighters represent an occupational group at increased suicide risk. How suicidality develops among firefighters is poorly understood. The depression-distress amplification model posits that the effects of depression symptoms on suicide risk will be intensified in the context of anxiety sensitivity (AS) cognitive concerns. The current study tested this model among firefighters. METHODS: Overall, 831 firefighters participated (mean [SD] age = 38...
April 7, 2018: Comprehensive Psychiatry
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