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https://www.readbyqxmd.com/read/27892602/the-analog-blanking-period-of-implantable-cardiac-rhythm-devices
#1
S Serge Barold, Andreas Kucher
BACKGROUND: Analog blanking periods (BP) that hold down the display of electrograms (EGM) in cardiac rhythm devices have received much less attention than the well-known digital blanking periods which do not influence the EGM display. In Biotronik devices, when a paced event initiates an analog BP in one chamber [right atrium (RA), right ventricle (RV) or left ventricle (LV)], an identical cross-chamber analog BP starts in the other 2 chambers. METHODOLOGY: All clinical observations were recorded from patients with Biotronik devices...
November 28, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27875987/biomarkers-of-cardiovascular-injury-and-stress-are-associated-with-increased-frequency-of-ventricular-ectopy-a-population-based-study
#2
Julia Brox Skranes, Gunnar Einvik, Silje Kjeka Namtvedt, Anna Randby, Harald Hrubos-Strøm, Jon Brynildsen, Tor-Arne Hagve, Virend K Somers, Helge Røsjø, Torbjørn Omland
BACKGROUND: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting...
November 22, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27844191/-indications-for-implantable-loop-recorders-in-patients-with-channelopathies-and-ventricular-tachycardias
#3
Julia Köbe, Kristina Wasmer, Florian Reinke, Lars Eckardt
Implantable loop recorders (ILR) do not play a pivotal role in the current guidelines on ventricular arrhythmias except in identifying rhythm-symptom correlations if ventricular arrhythmias are assumed. Before a decision for a pure diagnostic implantable device is made, a thorough arrhythmic risk assessment is of major importance due to the potential lethal outcome of ventricular arrhythmias. Nevertheless, some clinical circumstances exist where long-term monitoring by an ILR may add significant information in electrical heart diseases, in patients with ventricular arrhythmias, or structural heart diseases and a potential risk of ventricular arrhythmias...
November 14, 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/27834139/microrna-130a-regulation-of-desmocollin-2-in-a-novel-model-of-arrhythmogenic-cardiomyopathy
#4
Stefan R Mazurek, Tyler Calway, Cynthia Harmon, Priyanka Farrell, Gene H Kim
BACKGROUND: MicroRNAs are small noncoding RNA molecules that play a critical role in regulating physiological and disease processes. Recent studies have now recognized microRNAs as an important player in cardiac arrhythmogenesis. Molecular insight into arrhythmogenic cardiomyopathy (AC) has primarily focused on mutations in desmosome proteins. To our knowledge, models of AC due to microRNA dysregulation have not been reported. Previously, we reported on miR-130a mediated down-regulation of Connexin43...
November 9, 2016: MicroRNA
https://www.readbyqxmd.com/read/27799555/cardiac-electrical-defects-in-progeroid-mice-and-hutchinson-gilford-progeria-syndrome-patients-with-nuclear-lamina-alterations
#5
José Rivera-Torres, Conrado J Calvo, Anna Llach, Gabriela Guzmán-Martínez, Ricardo Caballero, Cristina González-Gómez, Luis J Jiménez-Borreguero, Juan A Guadix, Fernando G Osorio, Carlos López-Otín, Adela Herraiz-Martínez, Nuria Cabello, Alex Vallmitjana, Raul Benítez, Leslie B Gordon, José Jalife, José M Pérez-Pomares, Juan Tamargo, Eva Delpón, Leif Hove-Madsen, David Filgueiras-Rama, Vicente Andrés
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death. Prelamin A alterations also occur in physiological aging. It remains unknown how defective prelamin A processing affects the cardiac rhythm. We show age-dependent cardiac repolarization abnormalities in HGPS patients that are also present in the Zmpste24(-/-) mouse model of HGPS. Challenge of Zmpste24(-/-) mice with the β-adrenergic agonist isoproterenol did not trigger ventricular arrhythmia but caused bradycardia-related premature ventricular complexes and slow-rate polymorphic ventricular rhythms during recovery...
October 31, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27799236/effects-of-statin-on-arrhythmia-and-heart-rate-variability-in-healthy-persons-with-48-hour-sleep-deprivation
#6
Wei Ren Chen, Hong Bin Liu, Yuan Sha, Yang Shi, Hao Wang, Da Wei Yin, Yun Dai Chen, Xiang Min Shi
BACKGROUND: It has been reported that sleep deprivation is associated with cardiac autonomic disorder, inflammation, and oxidative stress. Statins have significant cardiovascular protective effects in patients with cardiovascular disease. This study aimed to investigate the protective effect of statins on arrhythmia and heart rate variability in young healthy persons after 48-hour sleep deprivation. METHODS AND RESULTS: This study enrolled 72 young healthy participants aged 26...
October 31, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27789001/trade-off-between-elimination-of-premature-ventricular-complexes-and-loss-of-synchronized-left-ventricular-pacing-improved-cardiac-function-in-a-patient-with-heart-failure
#7
Hideyuki Hasebe, Masataka Iida, Naoki Hatano, Toshiro Muramatsu
Synchronized left ventricular pacing (sLVP) via adaptive cardiac resynchronization therapy (aCRT) algorithm might enhance the efficacy of CRT. A 71-year-old female was admitted with the diagnosis of heart failure. Electrocardiograms revealed left bundle branch block with QRS width of 144 ms, and frequent premature ventricular complexes (PVCs). A CRT device was implanted, and sLVP via a CRT algorithm was provided. Frequent PVCs arising from the His-bundle suppressed effective sLVP percentage. Radiofrequency application at the His-bundle successfully eliminated the PVCs, but induced complete atrioventricular (AV) block, leading to loss of sLVP...
May 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/27765749/spontaneous-initiation-of-premature-ventricular-complexes-and-arrhythmias-in-type-2-long-qt-syndrome
#8
Xiaodong Huang, Tae Yun Kim, Gideon Koren, Bum-Rak Choi, Zhilin Qu
The occurrence of early afterdepolarizations (EADs) and increased dispersion of repolarization are two known factors for arrhythmogenesis in long QT syndrome. However, increased dispersion of repolarization tends to suppress EADs due to the source-sink effect, and thus how the two competing factors cause initiation of arrhythmias remains incompletely understood. Here we used optical mapping and computer simulation to investigate the mechanisms underlying spontaneous initiation of arrhythmias in type 2 long QT (LQT2) syndrome...
December 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27752746/clinical-values-of-left-ventricular-mechanical-dyssynchrony-assessment-by-gated-myocardial-perfusion-spect-in-patients-with-acute-myocardial-infarction-and-multivessel-disease
#9
Sang-Geon Cho, Zeenat Jabin, Ki Seong Park, Jahae Kim, Sae-Ryung Kang, Seong Young Kwon, Geum-Cheol Jeong, Minchul Song, Jong Sang Kim, Jae Yeong Cho, Hyun Kuk Kim, Ho-Chun Song, Jung-Joon Min, Hee-Seung Bom
PURPOSE: The aim of this study was to evaluate the prognostic value of additional evaluation of left ventricular mechanical dyssynchrony (LVMD) by gated myocardial perfusion single-photon emission computed tomography (GMPS) in patients with acute myocardial infarction (MI) and multivessel disease. METHODS: One hundred and nine acute MI patients with >50 % stenosis in at least one non-culprit artery who underwent GMPS within 2 weeks were enrolled. All patients underwent successful revascularization of the culprit arteries...
October 18, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27738397/qt-dispersion-and-ventricular-arrhythmias-in-children-with-primary-mitral-valve-prolapse
#10
Ebru Yalın İmamoğlu, Ayşe Güler Eroğlu
AIM: To investigate ventricular arrhythmias in children with primary mitral valve prolapse and to evaluate its relation with QT length, QT dispersion, autonomic function tests and heart rate variability measurements. MATERIAL AND METHODS: Fourty two children with mitral valve prolapse and 32 healthy children were enrolled into the study. Twelve-lead electrocardiograms, autonomic function tests, echocardiography and 24-hour rhythm Holter tests were performed. Electrocardiograms were magnified digitally...
September 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/27732926/quantitative-analysis-of-ventricular-ectopic-beats-in-short-term-rr-interval-recordings-to-predict-imminent-ventricular-tachyarrhythmia
#11
Marisol Martínez-Alanis, Silvia Ruiz-Velasco, Claudia Lerma
BACKGROUND: Most approaches to predict ventricular tachyarrhythmias which are based on RR intervals consider only sinus beats, excluding premature ventricular complexes (PVCs). The method known as heartprint, which analyses PVCs and their characteristics, has prognostic value for fatal arrhythmias on long recordings of RR intervals (>70,000 beats). OBJECTIVE: To evaluate characteristics of PVCs from short term recordings (around 1000 beats) and their prognostic value for imminent sustained tachyarrhythmia...
October 3, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27729344/non-reentrant-fascicular-tachycardia-clinical-and-electrophysiological-characteristics-of-a-distinct-type-of-idiopathic-ventricular-tachycardia
#12
Ahmed Karim Talib, Akihiko Nogami, Itsuro Morishima, Yasushi Oginosawa, Kenji Kurosaki, Shinya Kowase, Yuki Komatsu, Kenji Kuroki, Miyako Igarashi, Yukio Sekiguchi, Kazutaka Aonuma
BACKGROUND: The most common form of idiopathic Purkinje-related ventricular tachycardia (VT) is the reentrant type. We describe the clinical and electrophysiological characteristics of focal non-reentrant fascicular tachycardia. METHODS AND RESULTS: Among 530 idiopathic VT patients who were referred for ablation, we identified 15 (2.8%) with non-reentrant fascicular tachycardia (11 men, 45±21 years). Sinus rhythm ECG showed normal conduction intervals with a His-ventricular interval of 41±4 ms...
October 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27720380/twenty-four-hour-holter-monitoring-in%C3%A2-finishing-cattle-housed-outdoors
#13
D A Frese, J D Thomason, C Reinhardt, S Bartle, D Rethorst, G H Loneragan, D Thomson
INTRODUCTION: Atrial premature complexes have been reported to be the most common arrhythmia in cattle and is suspected to be secondary to systemic disease, especially gastrointestinal disease. In order to properly identify pathologic arrhythmia in cattle, the normal rhythm and arrhythmia prevalence should be defined. The objective of this study was to determine the normal heart rate, rhythm, number of ventricular premature complexes (VPCs), and atrial premature complexes (APCs) in unrestrained Angus steers...
October 6, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27664004/77-year-old-female-with-syncope
#14
Mahmoud A Abdelsalam, Jeffrey B Geske
CLINICAL INTRODUCTION: A 77-year-old female was referred for evaluation of an episode of syncope while eating breakfast. There was no history of fall, syncope, prodrome, dyspnoea, chest discomfort or palpitations. Medical history was notable for hyperlipidaemia and treated hypertension. Blood pressure was 140/90 mm Hg, pulse 85  beats per minute (BPM). No murmurs were present on cardiac examination. ECG revealed normal sinus rhythm with left ventricular (LV) hypertrophy (see online supplementary figure S1)...
September 23, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27642300/supine-frequent-ventricular-extrasystoles-in-a-pregnant-woman-without-structural-heart-disease
#15
Natália Stela Sandes Ferreira, Tatiana La Croix Barros, Ronaldo Altenburg Gismondi
Arrhythmias are the most common cardiac complication during gestational period and may occur in women with or without known structural heart disease. Premature extra beats and sustained tachyarrhythmias are the most common arrhythmias in pregnancy. Symptomatic episodes occur in 20-44% of pregnant women, usually as palpitations, dizziness, or syncope. We searched on Pubmed for ventricular premature complexes (VPC) in pregnant women and found no case reporting increased incidence of this arrhythmia while supine...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27568851/mismatch-between-the-origin-of-premature-ventricular-complexes-and-the-noncompacted-myocardium-in-patients-with-noncompaction-cardiomyopathy-patients-involvement-of-the-conduction-system
#16
Sophie Van Malderen, Sip Wijchers, Ferdi Akca, Kadir Caliskan, Tamas Szili-Torok
BACKGROUND: Noncompaction cardiomyopathy (NCCM) is considered to be the result of an arrest in the normal myocardial embryogenesis. The histological, developmental, and electrophysiological explanation of ventricular arrhythmias in NCCM is still unknown. The aim of this study was to determine the origin of premature ventricular contractions (PVCs) in NCCM and to identify any predominant arrhythmic foci. METHODS: Retrospective data from our NCCM registry including 101 patients were analyzed...
August 29, 2016: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/27553109/outcomes-of-combined-endocardial-epicardial-ablation-compared-with-endocardial-ablation-alone-in-patients-who-undergo-epicardial-access
#17
Ammar M Killu, Siva K Mulpuru, Mohammed A Al-Hijji, Alan Sugrue, Thomas M Munger, David O Hodge, Christopher J McLeod, Douglas L Packer, Suraj Kapa, Samuel J Asirvatham, Paul A Friedman
Percutaneous epicardial access (EpiAcc) is used in an attempt to improve outcomes of ablation. We aim to report our experience in EpiAcc for management of symptomatic ventricular premature complexes (VPC) and ventricular tachycardia (VT). All patients from January 2004 to July 2014 who underwent EpiAcc as part of a VPC or VT ablation procedure were included. Outcomes between those with endocardial-only (Gp1) and endocardial/epicardial (Gp2) ablation and those for VPC and VT ablation were compared. EpiAcc for VPC or VT ablation was attempted in 173 patients; 10 patients were excluded because of failure of access (n = 7) or no ablation performed (n = 3)...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27521096/sustained-ventricular-tachycardia-in-apparently-normal-hearts-medical-therapy-should-be-the-first-step-in%C3%A2-management
#18
REVIEW
Ali Kazemi Saeid, George J Klein, Peter Leong-Sit
Sustained monomorphic ventricular tachycardia or repetitive premature ventricular complexes can be seen in patients with structurally normal hearts. Among these types of patients, the prognosis is predominantly benign and the treatment mostly focused on elimination of symptoms rather than improving survival or reduction of mortality. This article focuses on the pharmacologic options for management and compares them with invasive options. Based on the current literature, we demonstrate that medical therapies should be used as first-line management and favored over invasive therapies...
September 2016: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/27521094/ventricular-arrhythmias-in-apparently-normal-hearts-who-needs-an-implantable-cardiac-defibrillator
#19
REVIEW
Alex Y Tan, Kenneth Ellenbogen
Idiopathic ventricular tachycardia is often considered a benign form of ventricular arrhythmia in patients without apparent structural heart disease. However, a subset of patients may develop malignant ventricular arrhythmias and present with syncope and sudden cardiac arrest. Survivors of cardiac arrest are candidates for implantable cardiac defibrillators (ICDs). The indications for ICDs in patients with less than a full-blown cardiac arrest presentation but with electrocardiographically high-risk ectopy features remain uncertain...
September 2016: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/27521090/spectrum-of-fascicular-arrhythmias
#20
REVIEW
Raphael Sung, Melvin Scheinman
Fascicular arrhythmias encompass a wide spectrum of ventricular arrhythmias that depend on the specialized conduction system of the right and left ventricles. These arrhythmias include premature ventricular complexes, monomorphic ventricular tachycardia, polymorphic ventricular tachycardia, and ventricular fibrillation. These arrhythmias may be organized by mechanism, including intrafascicular reentry, interfascicular reentry, and focal. Mapping and ablation of the fascicular system can result in high cure rates of debilitating and potentially life-threatening arrhythmias...
September 2016: Cardiac Electrophysiology Clinics
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