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https://www.readbyqxmd.com/read/29156005/abiofilm-a-resource-of-anti-biofilm-agents-and-their-potential-implications-in-targeting-antibiotic-drug-resistance
#1
Akanksha Rajput, Anamika Thakur, Shivangi Sharma, Manoj Kumar
Biofilms play an important role in the antibiotic drug resistance, which is threatening public health globally. Almost, all microbes mimic multicellular lifestyle to form biofilm by undergoing phenotypic changes to adapt adverse environmental conditions. Many anti-biofilm agents have been experimentally validated to disrupt the biofilms during last three decades. To organize this data, we developed the 'aBiofilm' resource (http://bioinfo.imtech.res.in/manojk/abiofilm/) that harbors a database, a predictor, and the data visualization modules...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155806/anogenital-distance-as-a-phenotypic-signature-through-infancy
#2
Lærke Priskorn, Jørgen H Petersen, Niels Jørgensen, Henriette B Kyhl, Marianne S Andersen, Katharina M Main, Anna-Maria Andersson, Niels E Skakkebaek, Tina K Jensen
BACKGROUND: Anogenital distance (AGD) has been suggested to represent a phenotypic signature reflecting in utero androgen action. However, it is not known whether an individual's AGD at birth correlates to AGD later in life. We investigate correlations of AGD between 3 and 18 months and asses reproducibility of measurements. METHODS: We measured AGD from anus to scrotum (AGDas) and penis (AGDap) in 407 boys, and to posterior fourchette (AGDaf) and clitoris (AGDac) in 282 girls...
November 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29155570/chemistry-antimicrobial-mechanisms-and-antibiotic-activities-of-cinnamaldehyde-against-pathogenic-bacteria-in-animal-feeds-and-human-foods
#3
Mendel Friedman
Cinnamaldehyde is a major constituent of cinnamon essential oils produced by aromatic cinnamon plants. This compound has been reported to exhibit antimicrobial properties in vitro in laboratory media and in animal feeds and human foods contaminated with disease-causing bacteria including Bacillus cereus, Campylobacter jejuni, Clostridium perfringens, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. This integrated review surveys and interprets our current knowledge of the chemistry, analysis, safety, mechanism of action, and antibiotic activities of cinnamaldehyde in food animal (cattle, lambs, calves, pigs, poultry) diets and in widely consumed liquid (apple, carrot, tomato, and watermelon juices, milk) and solid foods...
November 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29155270/efficient-hemorrhage-control-skills-training-for-healthcare-employees
#4
Richard A Sidwell, Sarah K Spilman, Richard S Huntsman, Carlos A Pelaez
BACKGROUND: Several national initiatives are aimed at training citizens to assist bleeding victims. The purpose of this study was to evaluate an effort to quickly and efficiently teach basic bleeding control techniques to a clinical and nonclinical workforce. STUDY DESIGN: The research study was conducted at four hospitals in a mid-sized metropolitan area. In spring 2017, the trauma department at a Level 1 trauma center set an ambitious goal to provide hands-on training to 1000 employees over the course of 6 weeks...
November 16, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29155233/autologous-hematopoietic-stem-cell-transplantation-in-systemic-sclerosis-a-reset-to-tolerance
#5
REVIEW
Femke C C van Rhijn-Brouwer, Julia Spierings, Jacob M van Laar
Autologous hematopoietic stem cell transplantation (ASCT) is an effective therapy for refractory autoimmune disease, in particular diffuse cutaneous systemic sclerosis (dcSSc). ASCT is the only treatment that can induce long term remission in dcSSc. However, the mechanism of action of ASCT has not yet been fully elucidated. The current hypothesis is that ASCT induces a long term 'reset' of the immune system, but there is no clear definition yet of such an immunological 'reset to tolerance', nor has it been established how to distinguish a 'reset' from long term immunosuppression...
November 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29154952/in-vitro-mechanisms-of-beauvericin-toxicity-a-review
#6
REVIEW
Beatriz Mallebrera, Alessandra Prosperini, Guillermina Font, Maria-Jose Ruiz
Beauvericin (BEA) is a mycotoxin produced by many species of fungus Fusarium and by Beauveria bassiana; BEA is a natural contaminant of cereals and cereals based products and possesses a wide variety of biological properties. The mechanism of action seems to be related to its ionophoric activity, that increases ion permeability in biological membranes. As a consequence, BEA causes cytotoxicity in several cell lines and is capable to produce oxidative stress at molecular level. Moreover, BEA is genotoxic (produces DNA fragmentation, chromosomal aberrations and micronucleus) and causes apoptosis with the involvement of mitochondrial pathway...
November 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29154804/event-related-brain-potentials-and-the-study-of-reward-processing-methodological-considerations
#7
REVIEW
Olave E Krigolson
There is growing interest in using electroencephalography and specifically the event-related brain potential (ERP) methodology to study human reward processing. Since the discovery of the feedback related negativity (Miltner et al., 1997) and the development of theories associating the feedback related negativity and more recently the reward positivity with reinforcement learning, midbrain dopamine function, and the anterior cingulate cortex (i.e., Holroyd and Coles, 2002) researchers have used the ERP methodology to probe the neural basis of reward learning in humans...
November 14, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29154724/understanding-how-a-palliative-specific-patient-reported-outcome-intervention-works-to-facilitate-patient-centred-care-in-advanced-heart-failure-a-qualitative-study
#8
Pauline M Kane, Clare I Ellis-Smith, Barbara A Daveson, Karen Ryan, Niall G Mahon, Brendan McAdam, Regina McQuillan, Cecelia Tracey, Christine Howley, Geraldine O'Gara, Caroline Raleigh, Irene J Higginson, Fliss Em Murtagh, Jonathan Koffman
BACKGROUND: Palliative care needs of patients with chronic heart failure are poorly recognised. Policy makers advise a patient-centred approach to holistically assess patients' needs and care goals. Patient-reported outcome measures are proposed to facilitate patient-centred care. AIM: To explore whether and how a palliative care-specific patient-reported outcome intervention involving the Integrated Palliative care Outcome Scale influences patients' experience of patient-centred care in nurse-led chronic heart failure disease management clinics...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29154687/pyruvate-enhancement-of-cardiac-performance-cellular-mechanisms-and-clinical-application
#9
Robert T Mallet, Albert H Olivencia-Yurvati, Rolf Bünger
Cardiac contractile function is adenosine-5'-triphosphate (ATP)-intensive, and the myocardium's high demand for oxygen and energy substrates leaves it acutely vulnerable to interruptions in its blood supply. The myriad cardioprotective properties of the natural intermediary metabolite pyruvate make it a potentially powerful intervention against the complex injury cascade ignited by myocardial ischemia-reperfusion. A readily oxidized metabolic substrate, pyruvate augments myocardial free energy of ATP hydrolysis to a greater extent than the physiological fuels glucose, lactate and fatty acids, particularly when it is provided at supra-physiological plasma concentrations...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29154630/automatic-imitation-of-multiple-agents-simultaneous-or-random-representation
#10
Emiel Cracco, Marcel Brass
Research has shown that the observation of another's movement activates the corresponding motor representation in the observer. However, it is largely unknown how activation of these shared representations is influenced by the number of observed agents. In recent work, we have studied automatic imitation while participants saw 2 hands of which either one hand or both hands made a movement. These studies found that 2 hands produced a stronger imitative response than a single hand when the hands made an identical movement but not when they made different movements...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154468/fight-flight-or-remain-silent-juggling-multiple-accountabilities-throughout-the-formative-stage-of-a-neighborhood-revitalization-initiative
#11
Stacey M Kesten, Deborah A Perez, Denise S Marques, Scot D Evans, Adrienne Sulma
This paper describes the experiences of a research team as they navigated uncertain ethical and political terrain throughout the formative stage of a public housing redevelopment project. Specifically, we discuss the challenges related to balancing multiple accountabilities and the tensions among the various roles and responsibilities that emanated from different accountabilities. Due to contractual obligations to our funding source, established relations with community partners, and an ethical imperative to align with those holding the least power, we grappled with embodying multiple and often conflicting roles...
November 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29154436/the-ecology-of-teachers-experiences-with-violence-and-lack-of-administrative-support
#12
Susan D McMahon, Samantha Reaves, Elizabeth A McConnell, Eric Peist, Linda Ruiz
Teacher-directed violence is a common, yet understudied, phenomenon. Perpetrators of violence against teachers include not just students, but also administrators, parents, and colleagues. Administrators are key stakeholders when it comes to shaping school climate and safety that can reduce or increase the negative impact of violence against teachers. In this study, 237 teachers' qualitative responses from a larger sample of 2,431 anonymous, online survey responses were examined to better understand their experiences with incidents of violence and how administrators played a role in these experiences...
November 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29154103/lung-cancer-messages-on-twitter-content%C3%A2-analysis-and-evaluation
#13
Jeannette Sutton, Sarah C Vos, Michele K Olson, Chelsea Woods, Elisia Cohen, C Ben Gibson, Nolan Edward Phillips, Jamie L Studts, Jan M Eberth, Carter T Butts
PURPOSE: The aim of this project was to describe and evaluate the levels of lung cancer communication across the cancer prevention and control continuum for content posted to Twitter during a 10-day period (September 30 to October 9) in 2016. METHODS: Descriptive and inferential statistics were used to identify relationships between tweet characteristics in lung cancer communication on Twitter and user-level data. Overall, 3,000 tweets published between September 30 and October 9 were assessed by a team of three coders...
November 15, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29153726/bioindicators-for-monitoring-marine-litter-ingestion-and-its-impacts-on-mediterranean-biodiversity
#14
REVIEW
Maria Cristina Fossi, Cristina Pedà, Montserrat Compa, Catherine Tsangaris, Carme Alomar, Francoise Claro, Christos Ioakeimidis, Francois Galgani, Tatjana Hema, Salud Deudero, Teresa Romeo, Pietro Battaglia, Franco Andaloro, Ilaria Caliani, Silvia Casini, Cristina Panti, Matteo Baini
The Mediterranean Sea has been described as one of the most affected areas by marine litter in the world. Although effects on organisms from marine plastic litter ingestion have been investigated in several oceanic areas, there is still a lack of information from the Mediterranean Sea. The main objectives of this paper are to review current knowledge on the impact of marine litter on Mediterranean biodiversity, to define selection criteria for choosing marine organisms suitable for use as bioindicator species, and to propose a methodological approach to assessing the harm related to marine litter ingestion in several Mediterranean habitats and sub-regions...
November 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29153180/a-100-year-review-progress-on-the-chemistry-of-milk-and-its-components
#15
John A Lucey, Don Otter, David S Horne
Understanding the chemistry of milk and its components is critical to the production of consistent, high-quality dairy products as well as the development of new dairy ingredients. Over the past 100 yr we have gone from believing that milk has only 3 protein fractions to identifying all the major and minor types of milk proteins as well as discovering that they have genetic variants. The structure and physical properties of most of the milk proteins have been extensively studied. The structure of the casein micelle has been the subject of many studies, and the initial views on submicelles have given way to the current model of the micelle as being assembled as a result of the concerted action of several types of interactions (including hydrophobic and the formation of calcium phosphate nanoclusters)...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29152872/authority-autonomy-and-deception-evaluating-the-legitimacy-of-parental-authority-and-adolescent-deceit
#16
Matthew Gingo, Alona D Roded, Elliot Turiel
This research examined adolescents' judgments about lying to avoid parental control over different types of activities. Participants (N = 66, Mage  = 16.38, 73% European American) were interviewed about hypothetical situations describing adolescents who defied parental directives and lied about their defiance. Judgments about the legitimacy of parents' directives and protagonists' deception differed by types of parent relationship with adolescents (mutual or unilateral). Directives were least accepted, and deception was most accepted, in the context of unilateral relationships...
December 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29152523/workshops-of-the-sixth-international-brain-computer-interface-meeting-brain-computer-interfaces-past-present-and-future
#17
Jane E Huggins, Christoph Guger, Mounia Ziat, Thorsten O Zander, Denise Taylor, Michael Tangermann, Aureli Soria-Frisch, John Simeral, Reinhold Scherer, Rüdiger Rupp, Giulio Ruffini, Douglas K R Robinson, Nick F Ramsey, Anton Nijholt, Gernot Müller-Putz, Dennis J McFarland, Donatella Mattia, Brent J Lance, Pieter-Jan Kindermans, Iñaki Iturrate, Christian Herff, Disha Gupta, An H Do, Jennifer L Collinger, Ricardo Chavarriaga, Steven M Chase, Martin G Bleichner, Aaron Batista, Charles W Anderson, Erik J Aarnoutse
The Sixth International Brain-Computer Interface (BCI) Meeting was held 30 May-3 June 2016 at the Asilomar Conference Grounds, Pacific Grove, California, USA. The conference included 28 workshops covering topics in BCI and brain-machine interface research. Topics included BCI for specific populations or applications, advancing BCI research through use of specific signals or technological advances, and translational and commercial issues to bring both implanted and non-invasive BCIs to market. BCI research is growing and expanding in the breadth of its applications, the depth of knowledge it can produce, and the practical benefit it can provide both for those with physical impairments and the general public...
2017: Brain Computer Interfaces
https://www.readbyqxmd.com/read/29152436/on-the-horizon-the-synthetic-opioid-u-49900
#18
EDITORIAL
Saeed K Alzghari, Zubair M Amin, Sophie Chau, Steven W Fleming, Kevin Cho, Victor Fung
Synthetic opioid use continues to be a problem in the United States. New designer opioids continue to be released as "research chemicals" by vendors, leading to widespread use and potentially devastating consequences. U-49900 is a new synthetic opioid with limited clinical data available. Herein, we provide an overview of U-49900, the anecdotal accounts of U-49900 use that clinicians need to be made aware of, and a call for the federal government to take immediate action in curtailing the use of U-49900.
September 12, 2017: Curēus
https://www.readbyqxmd.com/read/29152215/ozone-therapy-an-overview-of-pharmacodynamics-current-research-and-clinical-utility
#19
REVIEW
Noel L Smith, Anthony L Wilson, Jason Gandhi, Sohrab Vatsia, Sardar Ali Khan
The use of ozone (O3) gas as a therapy in alternative medicine has attracted skepticism due to its unstable molecular structure. However, copious volumes of research have provided evidence that O3's dynamic resonance structures facilitate physiological interactions useful in treating a myriad of pathologies. Specifically, O3 therapy induces moderate oxidative stress when interacting with lipids. This interaction increases endogenous production of antioxidants, local perfusion, and oxygen delivery, as well as enhances immune responses...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29151775/the-application-of-antimicrobial-photodynamic-therapy-apdt-in-dentistry-a-critical-review
#20
E T Carrera, H B Dias, S C T Corbi, R A C Marcantonio, A C A Bernardi, V S Bagnato, M R Hamblin, A N S Rastelli
In recent years there have been an increasing number of in vitro and in vivo studies that show positive results regarding antimicrobial photodynamic therapy (aPDT) used in dentistry. These include applications in periodontics, endodontics, and mucosal infections caused by bacteria present as biofilms. Antimicrobial photodynamic therapy is a therapy based on the combination of a non-toxic photosensitizer (PS) and appropriate wavelength visible light, which in the presence of oxygen is activated to produce reactive oxygen species (ROS)...
December 2016: Laser Physics
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