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P M Raste, B K Sahoo, J J Gaware, Anil Sharma, M R Waikar, A A Shaikh, R G Sonkawade
Researchers have already established that inhalation of high radon concentration is hazardous to human health. Radon concentration has been measured in water and soil, in various part of Kolhapur district has been carried out by the AQTEK Smart RnDuo which is an active device technique. The observed minimum value of the radon mass exhalation rate of the soil is 13.16 ± 0.83 mBq/kg/h and maximum is 35.11 ± 1.84 mBq/kg/h. The minimum value of the Radon concentration in water is 0.33 ± 0.052 Bq/L and maximum is 7...
March 19, 2018: Radiation Protection Dosimetry
Danieli Parreira da Silva Stalisz da Paixão, Josemar Batista, Eliane Cristina Sanches Maziero, Francine Taporosky Alpendre, Marly Ryoko Amaya, Elaine Drehmer de Almeida Cruz
OBJECTIVE: To investigate compliance of national patient safety protocols in Emergency Care Units (UPA) of the Paraná State. METHOD: From April until September 2016, the exploratory stage of the action research was conducted on stratified sampling with 377 patients of eight units, with use of verification instrument of basic safety actions. RESULTS: The absence of systematic identification of patients, fall risk assessment and signaling and development of pressure injuries were evidenced...
2018: Revista Brasileira de Enfermagem
Débora Cristina Martins Barbosa, Gabriela Ramos Furman, Aliny de Lima Santos, Carlos Alexandre Molena-Fernandes
OBJECTIVE: To estimate the prevalence of depression and to identify the main risk factors associated with depression in wives of convicted men. METHOD: Descriptive, cross - sectional, quantitative approach. The data were collected with 349 female partners of convicted patients in three penitentiaries in the state of Paraná, with a semistructured research, between January and June of 2016, being compiled in a database and analyzed using SPSS® 20.0 software. RESULTS: It was possible to identify vulnerability to depression among wives of convicted men, most were young and 42...
2018: Revista Brasileira de Enfermagem
Ritika S Joshi, Dipanwita Das Mukherjee, Subhendu Chakrabarty, Ansie Martin, Manojkumar Jadhao, Gopal Chakrabarti, Angshuman Sarkar, Sujit Kumar Ghosh
In the development of small molecule drug candidates, naphthalimide based compounds hold a very important position as potent anti-cancer agents with considerable safety in drug discoveries. Being synthetically and readily accessible, naphthalimide compounds with planar architecture have been developed mostly as DNA targeting intercalators. However, in this article, we demonstrate, for the first time, wherein an unfused naphthalimide-benzothiazole bichromophoric compound 2-(6-chlorobenzo[d] thiazol-2-yl)-1H-benzo[de] isoquinoline-1,3(2H)-dione (CBIQD), designed and synthesized by our group, seem to expand the bioactivity of naphthalimide as anti-mitotic agents also...
March 21, 2018: Journal of Physical Chemistry. B
Zhao-Xia Cao, An-Guo Liu, Tian-Tian Zhu, Xiao-Juan Li, Yu-Ting Wei, Xing-Ke Yan
Acupuncture has been found effective for the treatment of amblyopia, and its mechanism has been investigated. A review of recently published research results indicated that when used to treat amblyopia, acupuncture induced changes in the action of neurotransmitters in the visual system, promoted the secretion and synthesis of brain-derived neurotrophic factor, and stimulated the expression of genes related to visual plasticity.
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Martha J Nelson-Flower, Elizabeth M Wiley, Tom P Flower, Amanda R Ridley
Delayed dispersal is a key step in the evolution of familial animal societies and cooperative breeding. However, no consensus has been reached on the ecological and social circumstances driving delayed dispersal. Here, we test predictions from the ecological constraints and benefits of philopatry hypotheses as well as the recently proposed dual benefits hypothesis to better understand the evolution of group-living and cooperative breeding. Furthermore, we consider how individual social circumstances within groups affect dispersal decisions...
March 20, 2018: Journal of Animal Ecology
Yawei Xu, Yan Zhou, Rui Yin, Cheng Wang, Haijiao Chu, Junling Wang
The balance of oxidation and reduction in the body requires the synergistic effect of various antioxidant enzymes. Therefore, the construction of enzyme mimics with multiple antioxidant activities is important and beneficial for further research on the synergistic effects of antioxidant enzymes and their mechanism of action. To explore the synergistic effect of superoxide dismutase (SOD) and glutathione peroxidase (GPx), a 76-mer selenium-containing peptide (Se-76P) mimic containing the active SOD and GPx centers was designed...
March 20, 2018: In Vitro Cellular & Developmental Biology. Animal
Daisuke Ono, Ken-Ichi Honma, Yuchio Yanagawa, Akihiro Yamanaka, Sato Honma
In mammals, circadian rhythms, such as sleep/wake cycles, are regulated by the central circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN consists of thousands of individual neurons, which exhibit circadian rhythms. They synchronize with each other and produce robust and stable oscillations. Although several neurotransmitters are expressed in the SCN, almost all SCN neurons are γ-amino butyric acid (GABA)-ergic. Several studies have attempted to understand the roles of GABA in the SCN; however, precise mechanisms of the action of GABA in the SCN are still unclear...
March 20, 2018: Journal of Physiological Sciences: JPS
Hang Joon Jo, Kevin W McCairn, William S Gibson, Paola Testini, Cong Zhi Zhao, Krzysztof R Gorny, Joel P Felmlee, Kirk M Welker, Charles D Blaha, Bryan T Klassen, Hoon-Ki Min, Kendall H Lee
Background and objectives: Deep brain stimulation (DBS) of the thalamus is a promising therapeutic alternative for treating medically refractory Tourette syndrome (TS). However, few human studies have examined its mechanism of action. Therefore, the networks that mediate the therapeutic effects of thalamic DBS remain poorly understood. Methods: Five participants diagnosed with severe medically refractory TS underwent bilateral thalamic DBS stereotactic surgery. Intraoperative fMRI characterized the blood oxygen level-dependent (BOLD) response evoked by thalamic DBS and determined whether the therapeutic effectiveness of thalamic DBS, as assessed using the Modified Rush Video Rating Scale test, would correlate with evoked BOLD responses in motor and limbic cortical and subcortical regions...
2018: NeuroImage: Clinical
Eva Ceskova, Petr Silhan
In spite of tremendous development in central nervous system research, current treatment is suboptimal, especially in severe mental disorders. In medicine, there are two main methods of improving the health care provided: seeking new treatment procedures and perfecting (optimizing) the existing ones. Optimization of treatment includes not only practical tools such as therapeutic drug monitoring but also implementation of general trends in the clinical practice. New pharmacological options include new more sophisticated forms of monoaminergic drugs, old drugs rediscovered on the base of a better understanding of pathophysiology of mental illnesses, and drugs aimed at new treatment targets...
2018: Neuropsychiatric Disease and Treatment
Asghar Razmara, Teamur Aghamolaei, Abdoulhossain Madani, Zahra Hosseini, Shahram Zare
BACKGROUND: Road accidents are among the main causes of mortality. As safe and secure driving is a key strategy to reduce car injuries and offenses, the present research aimed to explore safe driving behaviours among taxi drivers based on the Health Belief Model (HBM). METHODS: This study was conducted on 184 taxi drivers in Bandar Abbas who were selected based on a multiple stratified sampling method. Data were collected by a questionnaire comprised of a demographic information section along with the constructs of the HBM...
March 20, 2018: BMC Public Health
Hee Kyoung Kang, Moon-Chang Choi, Chang Ho Seo, Yoonkyung Park
Various organisms exist in the oceanic environment. These marine organisms provide an abundant source of potential medicines. Many marine peptides possess anticancer properties, some of which have been evaluated for treatment of human cancer in clinical trials. Marine anticancer peptides kill cancer cells through different mechanisms, such as apoptosis, disruption of the tubulin-microtubule balance, and inhibition of angiogenesis. Traditional chemotherapeutic agents have side effects and depress immune responses...
March 20, 2018: International Journal of Molecular Sciences
Kelly M Goedert, Peii Chen, Anne L Foundas, A M Barrett
Spatial neglect commonly follows right hemisphere stroke. It is defined as impaired contralesional stimulus detection, response, or action, causing functional disability. While prism adaptation treatment is highly promising to promote functional recovery of spatial neglect, not all individuals respond. Consistent with a primary effect of prism adaptation on spatial movements, we previously demonstrated that functional improvement after prism adaptation treatment is linked to frontal lobe lesions. However, that study was a treatment-only study with no randomised control group...
March 20, 2018: Neuropsychological Rehabilitation
Guoqing Chen, Yong Li, Wei Wang, Liping Deng
Introduction Mangosteen as a rare and precious fruit looks like a queen crown, known as "Queen of Fruit". α-Mangostin (α-MG) is the most representative xanthone isolated from the pericarp of mangosteen, possessing extensive biological activities and pharmacological properties, which can be considered as an antineoplastic agent, antioxidant, anti-proliferation and induces apoptosis in various types of human cancer cells, and has protective effect on induced apoptotic damage. Areas covered The bioactivity and pharmacological Properties of α-MG are being actively investigated by various industrial and academic institutions...
March 20, 2018: Expert Opinion on Therapeutic Patents
Jun Yin, Man Chen, Xiaoting Wang, Xiaowei Ding
The chasing action, in which an actor chases a target, is a fundamental activity for the evolutionary shaping of social abilities. Where previous research has emphasized the chaser's role, the current study explored whether the fleeing responsivity of a chased target influences the cognitive representation of the chasing action. We investigated this with a change-detection task, in which a set of chasing actions, either exhibiting or not exhibiting fleeing behavior, were memorized in sequence, and it was tested whether a memorized action reappeared after altering an object's appearance...
March 19, 2018: Attention, Perception & Psychophysics
Pei-Pei Sun, Fu-Lun Tan, Zong Zhang, Yi-Han Jiang, Yang Zhao, Chao-Zhe Zhu
The mirror neuron system (MNS), mainly including the premotor cortex (PMC), inferior frontal gyrus (IFG), superior parietal lobule (SPL), and rostral inferior parietal lobule (IPL), has attracted extensive attention as a possible neural mechanism of social interaction. Owing to high ecological validity, functional near-infrared spectroscopy (fNIRS) has become an ideal approach for exploring the MNS. Unfortunately, for the feasibility of fNIRS to detect the MNS, none of the four dominant regions were found in previous studies, implying a very limited capacity of fNIRS to investigate the MNS...
2018: Frontiers in Human Neuroscience
Ying Liu, Brent Logan, Ning Liu, Zhiyuan Xu, Jian Tang, Yanzhi Wang
In this paper, we propose the first deep reinforcement learning framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state spaces than existing reinforcement learning methods to model real life complexity in heterogeneous disease progression and treatment choices, with the goal to provide doctor and patients the data-driven personalized decision recommendations. The proposed deep reinforcement learning framework contains a supervised learning step to predict the most possible expert actions; and a deep reinforcement learning step to estimate the long term value function of Dynamic Treatment Regimes...
August 2017: Healthcare Informatics: the Business Magazine for Information and Communication Systems
Ewa Bromek, Marta Rysz, Anna Haduch, Jacek Wojcikowski, Władysława Anna Daniel
Our recent work suggested a negative effect for the serotonergic innervation of the paraventricular nuclei (PVN) of the hypothalamus on growth hormone secretion and growth hormone-dependent expression of cytochrome P450 2C11 (CYP2C11). The aim of our present research was to determine the effect of the activation of the 5-HT1 or 5-HT2 receptors in the PVN on the expression and activity of cytochrome P450 in male rat liver. The serotonergic agonists 5-CT (5-carboxyamidotryptamine, a 5-HT1 receptor-type agonist), 8-OH-DPAT (8-hydroxy-2-(di-n-propyloamino)-tetralin, a 5-HT1A receptor agonist), sumatriptan (a 5-HT1B/D receptor agonist) and DOI (2,5-dimethoxy-4-iodoamphetamine, a 5-HT2A/C receptor agonist) were individually injected into the PVN...
March 19, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
M Yolanda Cobo-Nuñez, Mariam El Assar, Pedro Cuevas, Alberto Sánchez-Ferrer, Jennifer Martínez-González, Leocadio Rodríguez-Mañas, Javier Angulo
Etamsylate is indicated for several anti-hemorrhagic indications in human and veterinary medicine. However, etamsylate has been shown to be effective only in specific haemorrhagic situations. Furthermore, mechanism of action of etamsylate is not known but recent research has shown its ability to inhibit heparin binding to several growth factors. We have evaluated the ability of etamsylate to interfere with the activities of heparin. Effects of etamsylate on vasodilatory activity of heparin were evaluated in rat aortic segments...
March 16, 2018: European Journal of Pharmacology
Shanta R Dube
Currently, in the U.S. and worldwide, childhood trauma is a public health crisis. Childhood adversities, such as abuse, neglect, and related household stressors, are common, interrelated and contribute to multiple adverse social, behavioral and health outcomes throughout the lifespan. The present article provides further discussion regarding adverse childhood experiences (ACEs) screening in healthcare utilizing the etic and emic perspectives. Screening in the healthcare system leans toward the etic view: objective observations of symptoms, which may then lead to intervention delivery...
March 16, 2018: Child Abuse & Neglect
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