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Theraputic immunology

Lei Chen, Lin Liu, Tao Wang, Yong-chun Shen, Fu-qiang Wen
Receptor for advanced glycation end products (RAGE), a multiligand receptor, has been suggested to be implicated in inflammatory response. However, its role in chronic obstructive pulmonary disease (COPD) has not been well elucidated. Recently, several studies reported RAGE and its common ligands were upregulated in airways and lung tissues from COPD smokers. Moreover, inhibition of RAGE activation significantly attenuated cigarette smoke extract or bacteria-induced pulmonary inflammation. Based on these findings, a conclusion could be made that ligand-activated RAGE may play a key role in COPD and thus RAGE could be a new therapeutic target for COPD...
January 2013: Archives of Medical Research
Feng Lu, Hongwei Guo
The role of glucosamine hydrochloride in the pathogenesis of osteoarthritis in animal models of sponge granuloma, Kaolin arthritiaand and adjuant arthritis was studied. The results showed that glucosamine hydrochloride inhibited granulation, delayed immunoreactivity, immunological-reative arthritis in daily doses of 0.25-0.75 g/kg BW orally and vascular oozing, tissue swelling and cell isolating in daily doses of 0.5-1.5 g/kg BW orally, indicating that glucosamine hydrochloride might have a preventive and theraputic effect on osteoarthritis...
November 2003: Wei Sheng Yan Jiu, Journal of Hygiene Research
T B Petrova
Structure of the thymus in Wistar rats has been studied during antenatal and early postnatal periods of ontogenesis by means of histological, morphometric and electron microscopic methods. Theraputic doses of tetracycline hydrochloride have been administered during fetogenesis (15-20 days of pregnancy). An accelerated formation of the thymic structures, cellular blasttransformation in the thymic cortex and movement of lymphocytes from the cortex into medulla and increased secretory activity of epithelioreticulocytes have been revealed...
November 1984: Arkhiv Anatomii, Gistologii i émbriologii
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