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Thyroid children

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https://www.readbyqxmd.com/read/29240719/pericardial-effusion-as-a-presenting-symptom-of-hashimoto-thyroiditis-a-case-report
#1
Alberto Leonardi, Laura Penta, Marta Cofini, Lucia Lanciotti, Nicola Principi, Susanna Esposito
Background: Hashimoto thyroiditis (HT) is the most frequent cause of acquired hypothyroidism in paediatrics. HT is usually diagnosed in older children and adolescents, mainly in females and is rare in infants and toddlers with cardiac involvement, including pericardial effusion, that can be found in 10% to 30% of adult HT cases. In this paper, a child with HT and pericardial effusion as the most important sign of HT is described. Case presentation: A four-year-old male child suffering for a few months from recurrent abdominal pain sometimes associated with vomiting underwent an abdominal ultrasound scan outside the hospital...
December 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29240035/acinic-cell-carcinoma-of-the-parotid-gland-in-children-and-adolescents
#2
Shifra Ash, Isaac Yaniv, Raphael Feinmesser, Osnat Konen, Meora Feinmesser
Acinic cell carcinoma of the parotid gland is a rare low-grade malignant neoplasm. Data on children are sparse. For the present study, the database of a tertiary pediatric medical center was reviewed for all patients with parotid gland acinic cell carcinoma diagnosed and treated between 2004 and 2013. Clinical, histologic, treatment, and outcome parameters were collected from the medical files. Four patients were identified, 3 female and 1 male, aged 13.5 to 18 years (median 15.7) at diagnosis. One patient had a family history of parotid tumor and 1 of hypothyroidism/hyperthyroidism...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29234626/consumptive-hypothyroidism-case-report-of-hepatic-hemangioendotheliomas-successfully-treated-with-vincristine-and-systematic-review-of-the-syndrome
#3
Marina Weber Pasa, Rafael Selbach Scheffel, André Borsatto Zanella, Ana Luiza Maia, José Miguel Dora
Objectives: To provide a comprehensive description of consumptive hypothyroidism syndrome (CHS), a severe form of hypothyroidism that occurs due to the high expression levels of thyroid hormone inactivation enzyme type 3 deiodinase (D3) in tumors. Study Design: Case report and systematic review. Results: A 7-month-old girl with a diagnosis of massive hepatic hemangioendotheliomas was treated with high doses of thyroid hormones and tumor-directed chemotherapy with vincristine...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234623/are-perinatal-events-risk-factors-for-childhood-thyroid-autoimmunity
#4
Berglind Jonsdottir, Markus Lundgren, Sara Wallengren, Åke Lernmark, Ida Jönsson, Helena Elding Larsson
Background: Environmental and genetic factors possibly trigger thyroid autoimmunity. Studies on perinatal risk factors for childhood thyroid autoimmunity are sparse. Objectives: The aim was to investigate if perinatal factors, family history of autoimmune diseases, and HLA-DQ genotypes contribute to thyroid autoimmunity in the Diabetes Prediction in Skåne (DiPiS) study. Methods: Samples from 1,874 ten-year-old children were analyzed for autoantibodies to thyroid peroxidase (TPOAb), thyroglobulin (TGAb), and HLA-DQ genotypes...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29226569/children-born-by-women-with-rheumatoid-arthritis-have-increased-susceptibility-for-selected-chronic-diseases-a-nationwide-cohort-study
#5
Line R Jølving, Jan Nielsen, Ulrik S Kesmodel, Rasmus G Nielsen, Signe S Beck-Nielsen, Bente M Nørgård
OBJECTIVE: Fetal exposure to maternal rheumatoid arthritis (RA) might impact the long-term risk of disease in the offspring. We examined a possible association between maternal RA and 15 selected groups of chronic diseases in the offspring. METHODS: This nationwide cohort study was based on the Danish health registries and included data on all children born alive in Denmark from January 1st 1989 to December 31st 2013. The cohort comprised 2106 children born by women with RA (exposed), and 1 378 539 children born by women without RA (unexposed)...
December 11, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29225963/the-influence-of-juvenile-graves-ophthalmopathy-on-graves-disease-course
#6
Jurate Jankauskiene, Dalia Jarusaitiene
Purpose: To investigate juvenile Graves' ophthalmopathy (GO) signs and compare Graves' disease (GD) course in patients with or without GO. Patients and Methods: There were analyzed data (visual acuity, proptosis, palpebral fissure measurements, clinical activity score (CAS), and the course of GD) of 67 children who have been newly diagnosed with GD. 26.9% of patients with GD had signs of ophthalmopathy (GO+), and 73.1% were without ophthalmopathy (GO-). Results: Upper eyelid retraction (72...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29222896/serum-vitamin-b-12-in-children-presenting-with-vasovagal-syncope
#7
Ayhan Pektas, Resit Koken, Halit Bugra Koca
BACKGROUND AND OBJECTIVES: The present study aims to determine the serum vitamin B-12 in children presenting with vasovagal syncope. METHODS AND STUDY DESIGN: This is a prospective review of 160 children presenting with vasovagal syncope. Subgroup analysis was done based on the results of head up tilt test. RESULTS: Head up tilt test gave positive results in 80 children and yielded negative results in the remaining 80 children. The tilt test positive children had significantly lower thyroid stimulating hormone concentrations (p=0...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29221517/urban-rural-disparity-in-helicobacter-pylori-infection-related-upper-gastrointestinal-cancer-in-china-and-the-decreasing-trend-in-parallel-with-socioeconomic-development-and-urbanization-in-an-endemic-area
#8
Xiaoduo Wen, Denggui Wen, Yi Yang, Yuetong Chen, Guiying Wang, Baoen Shan
BACKGROUND: Globally China has the largest urban-rural disparity in socioeconomic development, and the urban-rural difference in upper gastrointestinal cancer (UGIC) is similar to the difference between developed and developing countries. OBJECTIVES: To describe urban-rural disparity in UGIC and to emphasize prevention by socioeconomic development and urbanization in China. METHODS: Age-standardized incidence rates (ASRs) of cancers in 2012 were compared between urban Shijiazhuang city and rural Shexian County, and trends from 2000-2015 in Shexian County were analyzed...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29220528/maternal-thyroid-function-in-early-pregnancy-and-neuropsychological-performance-of-the-child-at-5-years-of-age
#9
Stine Linding Andersen, Stig Andersen, Zeyan Liew, Peter Vestergaard, Jørn Olsen
Context: Abnormal maternal thyroid function in pregnancy may impair fetal brain development, but more evidence is needed to refine and corroborate the hypothesis. Objective: To estimate the association between maternal thyroid function in early pregnancy and neuropsychological performance of the child at 5 years of age. Design: Follow-up study. Participants: A cohort of 1,153 women and their children sampled from the Danish National Birth Cohort...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29207397/relationship-of-serum-fetuin-a-with-metabolic-and-clinical-parameters-in-german-children-and-adolescents-with-type-1-diabetes
#10
Christina Reinauer, Thomas Reinehr, Christina Baechle, Beate Karges, Julia Seyfarth, Katharina Foertsch, Martin Schebek, Joachim Woelfle, Michael Roden, Reinhard W Holl, Joachim Rosenbauer, Thomas Meissner
BACKGROUND AND AIM: The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients. METHODS: We studied the relationship between serum fetuin A and clinical diabetes-related data from the DPV registry (Diabetes-Pa-tienten-Verlaufsdokumentation) in 172 adolescent T1D patients with early-onset (<5 years) long-standing (>10 years) T1D...
December 5, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29204814/commentary-on-gay-male-only-children-evidence-for-low-birth-weight-and-high-maternal-miscarriage-rates-from-the-prenatal-thyroid-model-perspective
#11
Osman Sabuncuoglu
No abstract text is available yet for this article.
December 4, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29190168/the-effect-of-anti-thyroid-antibodies-positivity-on-children-with-primary-immune-thrombocytopenia
#12
Suzan O Mousa, Gamal T Soliman, Ahmed A-F Saedii, Emad N Hameed
Primary immune thrombocytopenia (ITP) is the most common cause of acquired thrombocytopenia in children. Anti-thyroid antibodies (aTA) have previously been found to be present in various autoimmune diseases. Our aim was to study the effect of aTA positivity (which are anti-thyroid peroxidase (aTPo) and/or anti-thyroglobulin (aTg)) on children with primary immune thrombocytopenia and their relation to treatment response. Sixty-one children with primary ITP were enrolled in the present study. They were further subdivided into: ND&P group (newly diagnosed and persistent) and chronic ITP group...
November 30, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29187654/-analysis-for-the-effect-of-different-regimens-on-ocular-myasthenia-gravis-in-children
#13
Chentao Liu, Xia Wang, Lili Xie, Jing Peng, Liwen Wu, Xiangrong Zheng
To evaluate the efficacy, recurrent risk factors and transferable ratio of treatments with 3 different regiments on children with systematic myasthenia gravis (MG).
 Methods: The data of 104 children with ocular MG from June 2010 to March 2014 were collected from Department of Pediatric Neurology of Xiangya Hospital and they were retrospectively studied. The patients were divided into 3 groups: a methylprednisolone group (n=44), a prednisone group (n=48) and a bromine pyridostigmine group (n=12). Evaluative system from American MG foundation was used to evaluate the efficacy of treatment and the ratio of ocular MG transformed into systematic MG...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29187393/outcomes-of-children-and-adolescents-with-advanced-hereditary-medullary-thyroid-carcinoma-treated-with-vandetanib
#14
Ira Lignugaris Kraft, Srivandana Akshintala, Yuelin J Zhu, Haiyan Lei, Claudia Derse-Anthony, Eva Dombi, Seth M Steinberg, Maya Lodish, Steven Waguespack, Oxana Kapustina, Elizabeth Fox, Frank M Balis, Maria J Merino, Paul S Meltzer, John Glod, Jack F Shern, Brigitte C Widemann
PURPOSE: Vandetanib is well-tolerated in patients with advanced medullary thyroid carcinoma (MTC). Long-term outcomes and mechanisms of MTC progression have not been reported previously.  Experimental Design:We monitored toxicities and disease status in patients taking vandetanib for hereditary, advanced MTC. Tumor samples were analyzed for molecular mechanisms of disease progression. RESULTS: Seventeen patients (8 male, age 13 (9-17)* years) enrolled; 16 had a RET p...
November 29, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29184815/transient-hypothyroidism-in-the-newborn-to-treat-or-not-to-treat
#15
REVIEW
Neelakanta Kanike, Ajuah Davis, Prem S Shekhawat
Transient congenital hypothyroidism (CH) refers to a temporary deficiency of thyroid hormone identified after birth, with low thyroxine (T4) and elevated thyrotropin (TSH), which later recovers to improved thyroxine production, typically in first few months of infancy. Approximately 17% to 40% of children diagnosed with CH by newborn screening (NBS) programs were later determined to have transient hypothyroidism. Causes of transient CH are prematurity, iodine deficiency, maternal thyrotropin receptor blocking antibodies, maternal intake of anti-thyroid drugs, maternal or neonatal iodine exposure, loss of function mutations and hepatic hemangiomas...
October 2017: Translational pediatrics
https://www.readbyqxmd.com/read/29182645/hla-and-non-hla-genes-and-familial-predisposition-to-autoimmune-diseases-in-families-with-a-child-affected-by-type-1-diabetes
#16
Anna Parkkola, Antti-Pekka Laine, Markku Karhunen, Taina Härkönen, Samppa J Ryhänen, Jorma Ilonen, Mikael Knip
Genetic predisposition could be assumed to be causing clustering of autoimmunity in individuals and families. We tested whether HLA and non-HLA loci associate with such clustering of autoimmunity. We included 1,745 children with type 1 diabetes from the Finnish Pediatric Diabetes Register. Data on personal or family history of autoimmune diseases were collected with a structured questionnaire and, for a subset, with a detailed search for celiac disease and autoimmune thyroid disease. Children with multiple autoimmune diseases or with multiple affected first- or second-degree relatives were identified...
2017: PloS One
https://www.readbyqxmd.com/read/29174431/pediatric-thyroid-cancer-patients-referred-to-high-volume-facilities-have-improved-short-term-outcomes
#17
Linda M Youngwirth, Mohamed A Adam, Samantha M Thomas, Sanziana A Roman, Julie A Sosa, Randall P Scheri
BACKGROUND: Thyroid cancer is the most common endocrine malignancy in children, albeit still rare. This study sought to measure the association between outcomes and case volume of the treatment facility for pediatric patients with thyroid cancer. METHODS: The National Cancer Data Base (1998-2011) was queried for all pediatric patients (age ≤ 18 years) with thyroid cancer. Demographic, clinical, and pathologic features were evaluated for all patients. Case volume of the treating facility was defined as the number of pediatric thyroid cancer patients at that facility during the study period...
November 22, 2017: Surgery
https://www.readbyqxmd.com/read/29174305/perinatal-hypothyroidism-increases-play-behaviors-in-juvenile-rats
#18
Spencer G Smith, Katharine V Northcutt
Thyroid hormones play an instrumental role in the development of the central nervous system. During early development, the fetus is dependent on maternal thyroid hormone production due to the dysfunction of its own thyroid gland. Thus, maternal thyroid dysfunction has been shown to elicit significant abnormalities in neural development, neurochemistry, and behavior in offspring. Previous reports have suggested that human maternal hypothyroidism may increase the chances of having children with autism spectrum disorder and attention-deficit/hyperactivity disorder...
November 21, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29171140/safety-and-efficacy-of-autoantigen-specific-therapy-with-2-doses-of-alum-formulated-glutamate-decarboxylase-in-children-with-multiple-islet-autoantibodies-and-risk-for-type-1-diabetes-a-randomized-clinical-trial
#19
Helena Elding Larsson, Markus Lundgren, Berglind Jonsdottir, David Cuthbertson, Jeffrey Krischer
OBJECTIVE: Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity. METHODS: In an investigator-initiated, double-blind, placebo-controlled clinical trial, non-diabetic children aged 4 to 17.9 years with autoantibodies to glutamate decarboxylase (GADA) and at least one of insulinoma-associated protein 2, insulin or zinc-transporter 8, were randomized, stratified by 2 or ≥3 islet autoantibodies, to 2 injections of 20 μg GAD-Alum or placebo, 30 days apart...
November 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29166388/associations-between-thyroid-dysfunction-and-developmental-status-in-children-with-excessive-iodine-status
#20
Inger Aakre, Tor A Strand, Khalil Moubarek, Ingrid Barikmo, Sigrun Henjum
BACKGROUND AND OBJECTIVE: Adequate iodine status and normal thyroid hormone synthesis are important for optimal child development. In this study, we explored whether young children's developmental status is associated with thyroid dysfunction in an area of chronic excessive iodine exposure. METHODS: We included 298 children between 18 and 48 months of age residing in Algerian refugee camps. Early child development was measured using the Ages and Stages Questionnaires, third edition (ASQ-3), consisting of five domains: Communication, Gross Motor, Fine Motor, Problem Solving and Personal-Social...
2017: PloS One
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