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Late preterm steroids

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https://www.readbyqxmd.com/read/27733360/antenatal-corticosteroids-for-maturity-of-term-or-near-term-fetuses-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Gabriele Saccone, Vincenzo Berghella
OBJECTIVE:  To evaluate the effectiveness of antenatal corticosteroids given at ≥34 weeks' gestation. DESIGN:  Systematic review with meta-analysis. DATA SOURCES:  Electronic databases were searched from their inception to February 2016. ELIGIBILITY CRITERIA FOR STUDY SELECTION:  Randomized clinical trials comparing antenatal corticosteroids with placebo or no treatment in women with a singleton pregnancy at ≥34 weeks' gestation...
October 12, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27651621/respiratory-morbidity-in-late-preterm-births-a-prospective-observational-study-at-a-tertiary-care-hospital
#2
Nazia Shaikh, Shaweez Faizi, Lavanya Rai
OBJECTIVES: To study the neonatal respiratory morbidity in late-preterm neonates. MATERIALS AND METHODS: This study was done over a period of 6 months (November 2014-April 2015) including 120 late-preterm births at a tertiary referral center. RESULTS: Among the 120 late-preterm babies, 42 (35 %) developed respiratory morbidity. Respiratory distress syndrome (RDS) developed in 43 % of the babies who had not received steroid prophylaxis against 25...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27613336/modeling-the-impact-of-growth-and-leptin-deficits-on-the-neuronal-regulation-of-blood-pressure
#3
Baiba Steinbrekera, Robert D Roghair
The risk of hypertension is increased by intrauterine growth restriction (IUGR) and preterm birth. In the search for modifiable etiologies for this life-threatening cardiovascular morbidity, a number of pathways have been investigated, including excessive glucocorticoid exposure, nutritional deficiency, and aberration in sex hormone levels. As a neurotrophic hormone intimately involved in cardiovascular regulation whose levels are influenced by glucocorticoids, nutritional status and sex hormones, leptin has emerged as a putative etiologic and thus therapeutic agent...
September 9, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27604074/pregnancy-outcomes-after-kidney-graft-in-italy-are-the-changes-over-time-the-result-of-different-therapies-or-of-different-policies-a-nationwide-survey-1978-2013
#4
Giorgina Barbara Piccoli, Gianfranca Cabiddu, Rossella Attini, Martina Gerbino, Paola Todeschini, Maria Luisa Perrino, Ana Maria Manzione, Gian Benedetto Piredda, Elisa Gnappi, Flavia Caputo, Giuseppe Montagnino, Vincenzo Bellizzi, Pierluigi Di Loreto, Francesca Martino, Domenico Montanaro, Michele Rossini, Santina Castellino, Marilisa Biolcati, Federica Fassio, Valentina Loi, Silvia Parisi, Elisabetta Versino, Antonello Pani, Tullia Todros
BACKGROUND: Kidney transplantation is the treatment of choice to restore fertility to women on renal replacement therapy. Over time, immunosuppressive, support therapies and approaches towards high-risk pregnancies have changed. The aim of this study was to analyse maternal-foetal outcomes in two cohorts of transplanted women who delivered a live-born baby in Italy in 1978-2013, dichotomized into delivery before and after January 2000. METHODS: A survey involving all the Italian transplant centres was carried out, gathering data on all pregnancies recorded since the start of activity at each centre; the estimated nationwide coverage was 75%...
July 5, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27577326/area-based-study-identifies-risk-factors-associated-with-missed-antenatal-corticosteroid-prophylaxis-in-women-delivering-preterm-infants
#5
Luigi Gagliardi, Carolina Amador, Monia Puglia, Federico Mecacci, Simone Pratesi, Emilio Sigali, Barbara Tomasini, Franca Rusconi
AIM: All women delivering a preterm infant should receive antenatal corticosteroid prophylaxis, but many miss this opportunity. We determined the risk factors associated with missed prophylaxis in a geographically defined area of Italy. METHODS: We prospectively studied all mothers who delivered babies between 24 and 31 completed weeks of gestation, from 2009 to 2013, in all maternity units in Tuscany. RESULTS: Of 1,232 mothers, 186 (15.1%) did not receive prophylaxis...
August 31, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27526255/systematic-review-and-meta-analysis-of-clinical-outcomes-of-early-caffeine-therapy-in-preterm-neonates
#6
Kok Pim Kua, Shaun Wen Huey Lee
AIMS: This study evaluated the therapeutic outcomes of early versus late caffeine therapy in preterm neonates. METHODS: We performed a systematic literature search in PubMed, Embase, CINAHL and CENTRAL from inception to 30 June 2016 to identify studies investigating the use of early caffeine therapy (initiated at less than 3 days of life) in preterm infants. Effect estimates were combined using random-effects meta-analysis. The primary outcomes for this study were bronchopulmonary dysplasia and mortality...
August 15, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27518672/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery
#7
LETTER
Gordon C S Smith
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27518671/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery
#8
LETTER
Anke Redlich, Ralf Böttger, Serban D Costa
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27518670/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery
#9
LETTER
Peter R Stutchfield, Sailesh Kotecha, Iolo J M Doull
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27518669/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery
#10
LETTER
Cynthia Gyamfi-Bannerman, Elizabeth A Thom
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27411106/antenatal-steroid-exposure-in-the-late-preterm-period-is-associated-with-reduced-cord-blood-neurotrophin-3
#11
Nicolette A Hodyl, Tara M Crawford, Lorna McKerracher, Andrew Lawrence, Julia B Pitcher, Michael J Stark
BACKGROUND: Neurotrophins are proteins critically involved in neural growth, survival and differentiation, and therefore important for fetal brain development. Reduced cord blood neurotrophins have been observed in very preterm infants (<32weeks gestation) who subsequently develop brain injury. Antenatal steroid exposure can alter neurotrophin concentrations, yet studies to date have not examined whether this occurs in the late preterm infant (33-36weeks gestation), despite increasing recognition of subtle neurodevelopmental deficits in this population...
October 2016: Early Human Development
https://www.readbyqxmd.com/read/27405904/morbidity-and-mortality-of-preterm-infants-less-than-26-weeks-of-gestational-age
#12
Maria I Durães, Filipa Flor-DE-Lima, Gustavo Rocha, Henrique Soares, Hercília Guimarães
BACKGROUND: Extreme preterm infants have a high risk of morbidity and mortality. Newborns delivered between 23+0 and 25+6 weeks, are considered to be in the "gray zone" and have uncertain prognosis. For these children medical decision-making becomes complex and controversial. The present study intends to evaluate the neonatal morbidity and mortality of preterm infants born between 23 weeks and 25+6 weeks of gestational age. METHODS: A retrospective study was conducted including all inborn preterm infants, with a gestational age between 23+0 and 25+6 weeks, admitted to a level IIIC NICU, between 1st January, 1996 and 31th December, 2014...
July 13, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27342043/antenatal-corticosteroids-beyond-34-weeks-gestation-what%C3%A2-do%C3%A2-we%C3%A2-do%C3%A2-now
#13
REVIEW
Beena D Kamath-Rayne, Paul J Rozance, Robert L Goldenberg, Alan H Jobe
The practice of antenatal corticosteroid administration in pregnancies of 24-34 weeks of gestation that are at risk of preterm delivery was adopted over 20 years after the first randomized clinical trial in humans. It is biologically plausible that antenatal corticosteroid in pregnancies beyond 34 weeks of gestation would reduce rates of respiratory morbidity and neonatal intensive care admission. Mostly guided by the results of a large multicenter randomized trial of antenatal corticosteroid in late preterm infants, the Antenatal Late Preterm Steroids Trial, the American Congress of Obstetricians and Gynecologists has released a practice advisory that the "administration of betamethasone may be considered in women with a singleton pregnancy between 34 0/7 and 36 6/7 weeks of gestation at imminent risk of preterm birth within 7 days...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27154242/ongoing-pharmacological-management-of-chronic-pain-in-pregnancy
#14
REVIEW
Bengt Källén, Margareta Reis
The article discusses possible effects of the use of analgesics during pregnancy. It summarizes the pertinent literature and reports some previously unpublished data from the Swedish Medical Birth Register. Most likely the use of analgesics does not cause spontaneous abortion. Only small malformation risk increases are seen after the use of opioids and perhaps non-steroid anti-inflammatory drug (NSAID) use. If possible, the latter should be avoided during the first trimester. If exposure has occurred there is no reason to consider an interruption of the pregnancy...
June 2016: Drugs
https://www.readbyqxmd.com/read/26895651/steroids-reduce-respiratory-problems-in-late-preterm-infants
#15
Roxanne Nelson
No abstract text is available yet for this article.
March 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/26796125/the-spectrum-of-onset-of-acute-kidney-injury-in-premature-infants-less-than-30-weeks-gestation
#16
A S Weintraub, J Connors, A Carey, V Blanco, R S Green
OBJECTIVE: To determine risk factors for acute kidney injury (AKI) in preterm infants as a function of time of onset. STUDY DESIGN: In this 5 1/2-year, single-center, retrospective study, incidence and timing of AKI was determined using modified Acute Kidney Injury Network criteria. Characteristics of newborns with and without AKI were compared by chi square and t-tests. Logistic regression was used to examine risk factors for AKI as a function of time of onset and potential confounders...
June 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/26733313/interaction-of-steroid-receptor-coactivators-and-estrogen-receptors-in-the-human-placenta
#17
Seung Chul Kim, Mee-Na Park, Young Joo Lee, Jong Kil Joo, Beum-Soo An
Female sex steroid hormones such as estrogen and progesterone have a pivotal role in maintaining pregnancy in human and animals. Especially, estrogen exerts specific effects on the cardiovascular system and angiogenesis, and thus affects significantly on placentation. Although the functions of estrogen have been emphasized during pregnancy, their signaling pathways in the placenta have not been fully understood. In this study, estrogen signaling was evaluated according to gestational age. Human placenta samples were collected and divided into early preterm (n=10), late preterm (n=18), and term (n=20) groups...
April 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/26677882/neonatal-morbidities-and-need-for-intervention-in-twins-and-singletons-born-at-34-35-weeks-of-gestation
#18
Michal J Simchen, Avital L Okrent Smolar, Mordechai Dulitzky, Eyal Sivan, Iris Morag
OBJECTIVE: To compare indications for delivery and neonatal morbidities between twins and singletons born between 34 and 35 weeks of gestation. STUDY DESIGN: A prospective observational study was performed in which all infants born between January and August 2008, at Sheba Medical Center at 34 0/7-35 6/7 weeks of gestational age were included. Indications for delivery, infants' morbidities and medical interventions were documented. Twins and singletons were compared for antenatal maternal characteristics, risks of short-term neonatal complications and interventions...
October 1, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/26590298/the-clinical-use-of-corticosteroids-in-pregnancy
#19
REVIEW
M W Kemp, J P Newnham, J G Challis, A H Jobe, S J Stock
BACKGROUND: The use of antenatal steroid therapy is common in pregnancy. In early pregnancy, steroids may be used in women for the treatment of recurrent miscarriage or fetal abnormalities such as congenital adrenal hyperplasia. In mid-late pregnancy, the antenatal administration of corticosteroids to expectant mothers in anticipation of preterm birth is one of the most important advances in perinatal medicine; antenatal corticosteroids are now standard care for pregnancies at risk of premature delivery in high- and middle-income countries...
March 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/26496004/the-fetal-brain-sparing-response-to-hypoxia-physiological-mechanisms
#20
Dino A Giussani
How the fetus withstands an environment of reduced oxygenation during life in the womb has been a vibrant area of research since this field was introduced by Joseph Barcroft, a century ago. Studies spanning five decades have since used the chronically instrumented fetal sheep preparation to investigate the fetal compensatory responses to hypoxia. This defence is contingent on the fetal cardiovascular system, which in late gestation adopts strategies to decrease oxygen consumption and redistribute the cardiac output away from peripheral vascular beds and towards essential circulations, such as those perfusing the brain...
March 1, 2016: Journal of Physiology
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