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https://www.readbyqxmd.com/read/29332977/the-role-of-wnt-signalling-in-angiogenesis
#1
REVIEW
Jun Jun Olsen, Sebastian Öther-Gee Pohl, Abhijeet Deshmukh, Malini Visweswaran, Natalie C Ward, Frank Arfuso, Mark Agostino, Arun Dharmarajan
Angiogenesis is a normal biological process wherein new blood vessels form from the growth of pre-existing blood vessels. Preventing angiogenesis in solid tumours by targeting pro-angiogenic factors including vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), basic fibroblast growth factor (bFGF), hepatocyte growth factor, and platelet-derived growth factor (PDGF) is currently under investigation for cancer treatment. Concurrently targeting the cell signalling pathways involved in the transcriptional and post-translational regulation of these factors may provide positive therapeutic results...
November 2017: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/29332578/amyloid-%C3%AE-inhibits-pdgf%C3%AE-receptor-activation-and-prevents-pdgf-bb-induced-neuroprotection
#2
Hui Liu, Golam T Saffi, Maryam S Vasefi, Youngjik Choi, Jeff S Kruk, Nawaz Ahmed, Nyasha Gondora, John Mielke, Zoya Leonenko, Michael A Beazely
PDGFβ receptors and their ligand, PDGF-BB, are upregulated in vivo after neuronal insults such as ischemia. When applied exogenously, PDGF-BB is neuroprotective against excitotoxicity and HIV proteins. METHODS: Given this growth factor's neuroprotective ability, we sought to determine if PDGF-BB would be neuroprotective against amyloid-β (1-42), one of the pathological agents associated with Alzheimer's disease (AD). In both primary hippocampal neurons and the human-derived neuroblastoma cell line, SH-SY5Y, amyloid- treatment for 24 h decreased surviving cell number in a concentration-dependent manner...
January 9, 2018: Current Alzheimer Research
https://www.readbyqxmd.com/read/29327677/autologous-smooth-muscle-progenitor-cells-enhance-regeneration-of-tissue-engineered-bladder
#3
Liuhua Zhou, Jiadong Xia, Pengji Wang, Ruipeng Jia, Jun Hua Zheng, Xudong Yao, Yun Chen, Yutian Dai, Bin Yang
Tissue engineering techniques provide a great potential to de novo construct a histological bladder. Smooth muscle regeneration is extremely important for the functional recovery of engineered neo-bladder. However, many challenges remain for the use of bladder smooth muscle cells (SMCs) as the cell sources. Recent evidences showed that smooth muscle progenitor cells (SPCs) in the peripheral blood have the capacity of differentiating into SMCs, while their use for bladder regeneration hasn't yet been reported...
January 12, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29325278/-effect-of-cannabinoid-receptor-2-agonist-am1241-on-platelet-derived-growth-factor-expression-in-the-liver-tissue-of-mice-with-hepatic-fibrosis
#4
P He, Y F Wu, H Y Yang, M L Cheng, Y D Liang, Y P Wang
Objective: To investigate the effect of cannabinoid receptor-2 (CB2) agonist AM1241 on the mRNA and protein expression of platelet-derived growth factor (PDGF) and collagen-III (Col-III) in the liver tissue of mice with experimental liver fibrosis induced by carbon tetrachloride (CCl(4)). Methods: Totally 38 8-week-old male C57BL/6J mice were randomly divided into control group, model group, 3 mg/kg CB2 receptor agonist (AM1241) group, and 9 mg/kg AM1241 group. All mice, except for the control group, were treated with 30% CCl(4) (three times a week, 5 ml/kg body weight, 16 weeks) to establish a liver fibrosis model...
November 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29325224/hereditary-kidney-cancer-syndromes-genetic-disorders-driven-by-alterations-in-metabolism-and-epigenome-regulation
#5
Hisashi Hasumi, Masahiro Yao
Although hereditary kidney cancer syndrome accounts for around five percent of all kidney cancers, the mechanistic insight into tumor development in these rare conditions has provided the foundation for the development of molecular targeting agents currently used for sporadic kidney cancer. In the late 1980s, the comprehensive study for hereditary kidney cancer syndrome was launched in the National Cancer Institute, U.S.A. and the first kidney cancer associated gene, VHL was identified through kindred analysis of von Hippel-Lindau syndrome in 1993...
January 11, 2018: Cancer Science
https://www.readbyqxmd.com/read/29319128/the-preliminary-study-on-expression-and-clinical-value-of-platelet-derived-growth-factor-bb-hypoxia-inducible-factor-1%C3%AE-and-c-c-motif-chemokine-receptor-2-in-the-peripheral-blood-during-the-pathogenesis-of-graves-disease
#6
Ying Liu, Jinglan Tang, Qiaohong Hu, Kefeng Lu, Chunjie Hou
Backgroud: Platelet-derived growth factor BB (PDGF-BB) plays an important role in the development of GD(Graves' disease). However, it is still unknown whether PDGF-BB is expressed in peripheral blood and whether the expression of PDGF-BB contributes to GD. We aim to study the expression of PDGF-BB, Hypoxia inducible factor(HIF)-1α and C-C motif chemokine receptor(CCR)-2 in peripheral blood of patients with GD and explore its effect and potential mechanism in pathogenesis. METHODS: 41 patients with GD (GD group) and 45 healthy people(control group) were chosen...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29317732/the-regulation-of-seventeen-inflammatory-mediators-are-associated-with-patient-outcomes-in-severe-fever-with-thrombocytopenia-syndrome
#7
Li-Fen Hu, Ting Wu, Bo Wang, Yuan-Yuan Wei, Qin-Xiang Kong, Ying Ye, Hua-Fa Yin, Jia-Bin Li
Severe fever with thrombocytopenia syndrome (SFTS) as an emerging infection disease results in high morbidity and mortality in China. In this study, the circulating levels of 36 inflammatory mediators in 33 SFTS patients on days 3-7, 8-12 and 13-20 post-illness were measured by a multiplex Luminex® system dynamically. Among the patients, 15 severe patients recovered, 11 severe patients died within three weeks. We found IL-1RA, IL-6, IL-15, IL-10, TNF-α, IFN-γ, G-CSF, eotaxin, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β and fractalkine were significantly upregulated in SFTS patients...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314868/bronchiolitis-obliterans-and-pulmonary-fibrosis-after-sulfur-mustard-inhalation-in-rats
#8
Matthew D McGraw, Marilyn M Dysart, Tara B Hendry-Hofer, Paul R Houin, Jacqueline S Rioux, Rhonda B Garlick, Joan E Loader, Russell Smith, Danielle C Paradiso, Wesley W Holmes, Dana R Anderson, Carl W White, Livia A Veress
RATIONALE: Inhalation of powerful chemical agents, such as sulfur mustard (SM), can have debilitating pulmonary consequences, such as bronchiolitis obliterans (BO) and parenchymal fibrosis (PF). The underlying pathogenesis of disorders after SM inhalation is not clearly understood, resulting in a paucity of effective therapies. OBJECTIVE: To evaluate the role of pro-fibrotic pathways involving TGF-β and PDGF in the development of BO and PF after inhalation injury sustained by SM, using a rat model...
January 9, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29306762/microfluidic-platform-for-single-cell-analysis-under-dynamic-spatial-and-temporal-stimulation
#9
Jiyoung Song, Hyunryul Ryu, Minhwan Chung, Youngtaek Kim, Yannick Blum, Sung Sik Lee, Olivier Pertz, Noo Li Jeon
Recent research on cellular responses is shifting from static observations recorded under static stimuli to real-time monitoring in a dynamic environment. Since cells sense and interact with their surrounding microenvironment, an experimental platform where dynamically changing cellular microenvironments should be recreated in vitro. There has been a lack of microfluidic devices to support spatial and temporal stimulations in a simple and robust manner. Here, we describe a microfluidic device that generates dynamic chemical gradients and pulses in both space and time using a single device...
December 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29305859/n-oleoylethanolamide-suppresses-intimal-hyperplasia-after-balloon-injury-in-rats-through-ampk-ppar%C3%AE-pathway
#10
Yun Zhao, Yijun Liu, Zuo Jing, Lu Peng, Peng Jin, Yangbin Lin, Yu Zhou, Lichao Yang, Jie Ren, Qiang Xie, Xin Jin
Vascular smooth muscle cell (VSMC) proliferation and migration are crucial events in the pathological course of restenosis after percutaneous coronary intervention (PCI). N-oleoylethanolamide (OEA) is a bioactive lipid amide released upon dietary fat digestion with many reported actions. However, the effect of OEA on restenosis after vascular injury remains unknown. Here, we investigated the effects of OEA on intimal hyperplasia after balloon injury in vivo, its effect on VSMC proliferation and migration induced by platelet-derived growth factor (PDGF) stimulation in vitro, and the underlying mechanism underlying these effects...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29301090/evaluation-of-therapeutic-effect-of-rice-husk-silica-combined-with-platelets-derived-growth-factor-in-hepatic-veno-occlusive-disease
#11
Eithar K Al Adham, Amal I Hassan, M M Hazem, Ahmed Shebl
Veno- occlusive disease is an important pattern of hepatotoxicity associated with antineoplastic drugs. The study aimed to investigate the possible therapeutic impact of rice husk silica (RHS) nanoparticles combined with a platelet-derived growth factor (PDGF) on the Veno-occlusive disease in liver (VOD) elicited by dactinomycin (DAC) in rats. Forty-eight male Sprague-Dawely rats were classified into six groups, 8 rats each. The first group served as control, the second, animals were infused by intraperitoneal injection with DAC (0...
January 4, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29298514/increased-calcitonin-gene-related-peptide-and-macrophages-are-involved-in-astragalus-membranaceus-mediated-peripheral-nerve-regeneration-in-rats
#12
Chung-Chia Chen, Ling-Chuan Chang, Chun-Hsu Yao, Yuan-Man Hsu, Jia-Horng Lin, Tse-Yen Yang, Yung-Hsiang Chen, Yueh-Sheng Chen
Astragalus membranaceus (AM) is one of 50 fundamental herbs in traditional Chinese medicine. Previous studies have shown that AM extract can be a potential nerve growth-promoting factor, being beneficial for the growth of peripheral nerve axons. We further investigated the effects of AM extract on regeneration in a rat sciatic nerve transection model. Rats were divided into three groups ([Formula: see text]): normal saline (intraperitoneal) as the control, and 1.5[Formula: see text]g/kg or 3.0[Formula: see text]g/kg of AM extract (every other day for four weeks), respectively...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29298329/molecular-and-functional-analysis-of-anchorage-independent-treatment-evasive-neuroblastoma-tumorspheres-with-enhanced-malignant-properties-a-possible-explanation-for-radio-therapy-resistance
#13
Tamara J Abou-Antoun, Javad Nazarian, Anthony Ghanem, Stanislav Vukmanovic, Anthony D Sandler
Despite significant advances in cancer treatment and management, more than 60% of patients with neuroblastoma present with very poor prognosis in the form of metastatic and aggressive disease. Solid tumors including neuroblastoma are thought to be heterogeneous with a sub-population of stem-like cells that are treatment-evasive with highly malignant characteristics. We previously identified a phenomenon of reversible adaptive plasticity (RAP) between anchorage dependent (AD) cells and anchorage independent (AI) tumorspheres in neuroblastoma cell cultures...
2018: PloS One
https://www.readbyqxmd.com/read/29285255/agrin-para-secreted-by-pdgf-activated-human-hepatic-stellate-cells-promotes-hepatocarcinogenesis-in-vitro-and-in-vivo
#14
Xing Lv, Cheng Fang, Ruozhe Yin, Bowei Qiao, Runze Shang, Jianlin Wang, Wenjie Song, Yong He, Yong Chen
Evaluating the process and mechanism of fibrogenesis is essential in hepatocellular carcinoma (HCC), especially in hepatocyte transformation and oncogenic signaling. We evaluated the oncogenic role of agrin secreted by platelet-derived growth factor (PDGF)-induced hepatic stellate cell (HSC) in HCC. Cells were co-cultured to investigate the effect of activated HSC on hepatocytes. Liquid chromatography and protein profiling analysis were used to search the distinct proteins secreted in HSC supernatant. Sprague Dawley rats with Diethylnitrosamine (DEN)-induced HCC were used to simulate human liver cancer and sorafenib was administered to investigate its effect on hepatocarcinogenesis...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29276926/-pathogenetic-and-prognostic-role-of-growth-factors-in-the-development-of-chronic-heart-failure
#15
A T Teplyakov, E N Berezikova, S N Shilov, A V Efremova, M G Pustovetova, A A Popova, E V Grakova, Y Y Torim, I D Safronov, A V Andriyanova
AIM: To study the role of growth factors ((vascular endothelial growth factor (VEGF), platelet derived growth factor AB (PDGF-AB) and basic fibroblast growth factor (FGF-basic)) in the development and progression of chronic heart failure (CHF) in patients with ishcemic heart disease (IHD). MATERIALS AND METHODS: We included in this study 94 patients with CHF. The control group comprised 32 persons. Blood serum levels of growth factors were determined at baseline and after 12 months of observation by enzyme-linked immunosorbent assay...
October 2017: Kardiologiia
https://www.readbyqxmd.com/read/29275861/natural-killer-cells-control-tumor-growth-by-sensing-a-growth-factor
#16
Alexander D Barrow, Melissa A Edeling, Vladimir Trifonov, Jingqin Luo, Piyush Goyal, Benjamin Bohl, Jennifer K Bando, Albert H Kim, John Walker, Mary Andahazy, Mattia Bugatti, Laura Melocchi, William Vermi, Daved H Fremont, Sarah Cox, Marina Cella, Christian Schmedt, Marco Colonna
Many tumors produce platelet-derived growth factor (PDGF)-DD, which promotes cellular proliferation, epithelial-mesenchymal transition, stromal reaction, and angiogenesis through autocrine and paracrine PDGFRβ signaling. By screening a secretome library, we found that the human immunoreceptor NKp44, encoded by NCR2 and expressed on natural killer (NK) cells and innate lymphoid cells, recognizes PDGF-DD. PDGF-DD engagement of NKp44 triggered NK cell secretion of interferon gamma (IFN)-γ and tumor necrosis factor alpha (TNF-α) that induced tumor cell growth arrest...
December 20, 2017: Cell
https://www.readbyqxmd.com/read/29274477/intrafibrillar-silicified-collagen-scaffold-promotes-in-situ-bone-regeneration-by-activating-the-monocyte-p38-signaling-pathway
#17
Jin-Long Sun, Kai Jiao, Qun Song, Chu-Fan Ma, Chao Ma, Franklin R Tay, Li-Na Niu, Ji-Hua Chen
Intrafibrillar silicified collagen scaffold (SCS) is a promising biomaterial for bone regeneration because it promotes cell homing and angiogenesis in bone defects via monocyte modulation. In the present study, a rat femoral defect model was used to examine the contribution of monocyte signaling pathways to SCS modulation. Activation of the monocyte p38 signaling pathway by SCS resulted in monocyte differentiation into TRAP-positive mononuclear cells. These cells demonstrated increased secretion of SDF-1α, VEGFa and PDGF-BB, which, in turn, promoted homing of bone marrow stromal cells (BMSCs) and endothelial progenitor cells (EPCs), as well as local vascularization...
December 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29273278/co-expression-of-pdgf-b-and-vegfr-3-strongly-correlates-with-poor-prognosis-in-hepatocellular-carcinoma-patients-after-hepatectomy
#18
Bin Chen, Jinghua Liu, Xionghua Wang, Qian Shen, Chao Li, Chunshan Dai
BACKGROUND: The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) patients following hepatectomy with biological markers is of great importance. METHODS: In this study, we collected samples from 90 patients with HCC after hepatectomy. Immunohistochemistry was used to detect the expression of PDGF-B and VEGFR-3 in these HCC samples. RESULTS: According to the immunohistochemical results, PDGF-B and VEGFR-3 staining were significantly associated with clinical features...
December 19, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29259043/platelet-derived-growth-factor-bb-stimulates-differentiation-of-rat-immature-leydig-cells
#19
Yiyan Wang, Xiaoheng Li, Fei Ge, Kaiming Yuan, Zhijian Su, Guimin Wang, Qingquan Lian, Ren-Shan Ge
Platelet-derived growth factor (PDGF) is one family of growth factors that regulate cell growth and differentiation. Rat Leydig cells express PDGF-β receptor (PDGFRB) during pubertal development. However, the mechanism of PDGF in the regulation of Leydig cell development is unclear. In the present study, rat immature Leydig cells were isolated from the testes of 35-day-old Sprague-Dawley rats and treated with 1 and 10 ng/mL of PDGF-BB. After 24 h of treatment, these cells were harvested for genomics profiling and the medium steroids were measured...
January 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29258450/serum-cytokine-profiles-predict-survival-benefits-in-patients-with-advanced-hepatocellular-carcinoma-treated-with-sorafenib-a-retrospective-cohort-study
#20
Tomoyuki Hayashi, Taro Yamashita, Takeshi Terashima, Tsuyoshi Suda, Hikari Okada, Yoshiro Asahina, Takehiro Hayashi, Yasumasa Hara, Kouki Nio, Hajime Sunagozaka, Hajime Takatori, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
BACKGROUND: Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that serum cytokines levels could predict the survival of advanced HCC patients, as sorafenib targets signaling pathways activated in the tumor stromal microenvironment and potentially affects serum cytokine profiles...
December 19, 2017: BMC Cancer
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