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https://www.readbyqxmd.com/read/30006481/apoptosis-signal-regulating-kinase-1-ask1-inhibition-attenuates-human-airway-smooth-muscle-growth-and-migration-in-chronic-obstructive-pulmonary-disease-copd
#1
Mathew S Eapen, Anudeep Kota, Howard Vindin, Kielan D McAlinden, Dia Xenaki, Brian G Oliver, Deepak A Deshpande, Sukhwinder Singh Sohal, Pawan Sharma
Increased airway smooth muscle (ASM) mass is observed in COPD which is correlated with disease severity and negatively impact lung function. Thus, there is clear unmet clinical need for finding new therapies which can target airway remodeling and disease progression in COPD. Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein kinase kinase kinase  activated by various stress stimuli, including reactive oxygen species, tumor necrosis factor-α, and lipopolysaccharide and is known to regulate cell proliferation...
July 13, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/30003342/injectable-platelet-rich-fibrin-cell-content-morphological-and-protein-characterization
#2
Hugo Almeida Varela, Júlio C M Souza, Rubens M Nascimento, Raimundo F Araújo, Roseane C Vasconcelos, Rômulo S Cavalcante, Paulo M Guedes, Aurigena A Araújo
OBJECTIVES: The aim of the present study was to evaluate the blood cell content, morphological aspects, gene expression of type I collagen, and release of growth factors on an injectable platelet rich fibrin (i-PRF). MATERIALS AND METHODS: Blood samples were collected from 15 volunteers to prepare i-PRF samples. Peripheral blood was used as a control group. Blood clot and i-PRF samples were cultured for 10 days. The supernatant of the samples was collected for ELISA immunoassay quantification of PDGF and VEGF growth factors over periods of 1, 8, 24, 72, and 240 h...
July 12, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29997150/modulation-of-circulating-protein-biomarkers-in-cancer-patients-receiving-bevacizumab-and-the-anti-endoglin-antibody-trc105
#3
Yingmiao Liu, Mark D Starr, John C Brady, Christel Rushing, Herbert Pang, Bonne Adams, Delia Alvarez, Charles P Theuer, Herbert I Hurwitz, Andrew B Nixon
TRC105 is an anti-endoglin antibody currently being tested in combination with VEGF inhibitors. In the phase Ib trial, 38 patients were treated with both TRC105 and bevacizumab (BEV) and improved clinical outcomes were observed, despite the fact that 30 patients (79%) were refractory to prior anti-VEGF therapy. Plasma samples were tested for angiogenic and inflammatory biomarkers at baseline and on-treatment. To provide broader context of this combination biomarker study, direct cross-study comparisons were made to biomarker studies previously conducted in patients treated with either BEV or TRC105 monotherapy...
July 11, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29996202/-the-effects-of-macrophages-with-high-expression-of-tl1a-on-activation-and-proliferation-of-hepatic-stellate-cells-in-vitro
#4
Y X Luo, J B Guo, F R Yin, X X Huo, L B Zheng, H Zhang, X L Zhang
Objective: To explore the effects of macrophages with high expression of TL1A on the activation and proliferation of HSCs in vitro. Methods: The Bone marrow-derived macrophages (BMMs) and peritoneal macrophages (PMs) from wild type (WT) and myeloid-overexpressed TL1A transgenic mice were isolated, differentiated and activated. HSCs were harvested from activated macrophages culture supernatant (CM). HSCs were detected by immunofluorescence and real-time Q-PCR. And the proliferation was detected by CCK-8 and BrdU assay kit...
May 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29989578/-inactivation-of-receptor-tyrosine-kinases-overcomes-resistance-to-targeted-b-raf-inhibitors-in-melanoma-cell-lines
#5
O O Ryabaya, A A Malysheva, Yu A Khochenkova, E Sh Solomko, D A Khochenkov
The discovery of B-RAF activating mutations in malignant melanoma cells has led to the development of a number of targeted drugs, which block exclusively the mutant B-RAF protein. Tumor cells often acquire resistance to B-RAF inhibitors via activation of alternative signaling pathways. One of the resistance mechanisms is activation of PDGF, VEGF, c-KIT, and certain other tyrosine kinases. The possibility of overcoming the resistance to the B-RAF inhibitor Vemurafenib by inactivating receptor tyrosine kinases (RTKs) was studied in metastatic melanoma cell lines differing in B-RAF mutations and RTK activity...
May 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29986685/protective-effects-of-liuweiwuling-tablets-on-carbon-tetrachloride-induced-hepatic-fibrosis-in-rats
#6
Huimin Liu, Zhenfang Zhang, Huangwanyin Hu, Congen Zhang, Ming Niu, Ruishen Li, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
BACKGROUND: Liuweiwuling tablets (LWWL) are an herbal product that exerts remarkable effects on liver protection and aminotransferase levels, and they have been approved by the Chinese State Food and Drug Administration (CFDA). Clinical studies have found that LWWL can inhibit collagen production and reduce the levels of liver fibrosis markers in the serum. Thus, LWWL is expected to have beneficial effects in the treatment of liver fibrosis. The purpose of this study was to evaluate the pharmacological effects of LWWL...
July 9, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29985958/kshv-induced-ligand-mediated-activation-of-pdgf-receptor-alpha-drives-kaposi-s-sarcomagenesis
#7
Lucas E Cavallin, Qi Ma, Julian Naipauer, Sachin Gupta, Mani Kurian, Paola Locatelli, Paolo Romanelli, Mehrdad Nadji, Pascal J Goldschmidt-Clermont, Enrique A Mesri
Kaposi's sarcoma (KS) herpesvirus (KSHV) causes KS, an angiogenic AIDS-associated spindle-cell neoplasm, by activating host oncogenic signaling cascades through autocrine and paracrine mechanisms. Tyrosine kinase receptor (RTK) proteomic arrays, identified PDGF receptor-alpha (PDGFRA) as the predominantly-activated RTK in KSHV-induced mouse KS-tumors. We show that: 1) KSHV lytic replication and the vGPCR can activate PDGFRA through upregulation of its ligands PDGFA/B, which increase c-myc, VEGF and KSHV gene expression in infected cells 2) Most KSHV infected spindle cells of KS lesions display robust phospho-PDGFRA staining 3) blocking PDGFRA-signaling with N-acetyl-cysteine, RTK-inhibitors Imatinib and Sunitinib, or dominant-negative PDGFRA inhibits tumorigenesis 4) PDGFRA D842V activating-mutation confers resistance to Imatinib in mouse-KS tumorigenesis...
July 9, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29984922/-an-in-vitro-study-of-the-angiogenic-effects-of-concentrate-growth-factor-on-human-umbilical-vein-endothelial-cells
#8
Jun Huan, Lei Dou, Qi-Fang Yan, De-Qin Yang
OBJECTIVE: This study aimed to explore the effects of concentrate growth factor extracts (CGFe) on human umbilical vein endothelial cells (HUVECs) in vitro. METHODS: Concentrate growth factor (CGF) were prepared from the peripheral blood of healthy donors, followed by CGFe. Four groups were designed based on cell culture medium, as follows: 2%CGFe, 5%CGFe, 10%CGFe, and control. The proliferation activity of HUVECs was detected by cell cycle and CCK-8 assays. The migration of HUVECs was detected by scratch assay...
June 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29982985/growth-factors-and-neuroglobin-in-astrocyte-protection-against-neurodegeneration-and-oxidative-stress
#9
REVIEW
Ricardo Cabezas, Eliana Baez-Jurado, Oscar Hidalgo-Lanussa, Valentina Echeverria, Ghulam Md Ashrad, Amirhossein Sahebkar, George E Barreto
Neurodegenerative diseases, such as Parkinson and Alzheimer, are among the main public health issues in the world due to their effects on life quality and high mortality rates. Although neuronal death is the main cause of disruption in the central nervous system (CNS) elicited by these pathologies, other cells such as astrocytes are also affected. There is no treatment for preventing the cellular death during neurodegenerative processes, and current drug therapy is focused on decreasing the associated motor symptoms...
July 7, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29982434/critical-role-of-histone-demethylase-jmjd3-in-the-regulation-of-neointima-formation-following-vascular-injury
#10
XiaoLing Luo, Di Yang, WeiJun Wu, Fen Long, ChenXi Xiao, Ming Qin, Betty YuenKwan Law, Rinkiko Suguro, Xin Xu, LeFeng Qu, XinHua Liu, Yi Zhun Zhu
Aims: Jumonji domain-containing protein 3 (JMJD3), also called lysine specific demethylase 6B (KDM6b), is an inducible histone demethylase which plays an important role in many biological processes, however, its function in vascular remodeling remains unknown. We aim to demonstrate that JMJD3 mediates vascular neointimal hyperplasia following carotid injury, and proliferation and migration in platelet-derived growth factor BB (PDGF-BB)-induced vascular smooth muscle cells (VSMCs). Methods and results: By using both genetic and pharmacological approaches, our study provides the first evidence that JMJD3 controls PDGF-BB-induced VSMCs proliferation and migration...
July 4, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29973153/immune-responses-in-the-treatment-of-drug-sensitive-pulmonary-tuberculosis-with-phenylbutyrate-and-vitamin-d-3-as-host-directed-therapy
#11
Rokeya Sultana Rekha, Akhirunnesa Mily, Tajnin Sultana, Ahsanul Haq, Sultan Ahmed, S M Mostafa Kamal, Annemarie van Schadewijk, Pieter S Hiemstra, Gudmundur H Gudmundsson, Birgitta Agerberth, Rubhana Raqib
BACKGROUND: We have previously shown that 8 weeks' treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D3 (vitD3 ) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum culture conversion and increased expression of cathelicidin LL-37 by immune cells in a randomized, placebo-controlled trial in adults with pulmonary tuberculosis (TB). In this study we further aimed to examine whether HDT with PBA and vitD3 promoted clinically beneficial immunomodulation to improve treatment outcomes in TB patients...
July 4, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29972714/thymosin-%C3%AE-4-suppresses-ccl-4-induced-murine-hepatic-fibrosis-by-down-regulating-transforming-growth-factor-%C3%AE-receptor-ii
#12
Hanchao Li, Qian Li, Xueting Zhang, Xiaoyan Zheng, Qiannan Zhang, Zhiming Hao
AIM: To clarify the effects of thymosin β4 (Tβ4) on CCl4 -induced hepatic fibrosis in mice and further explore the underlying mechanisms. METHODS: Expression of Tβ4 in fibrotic liver tissues was assessed by real-time quantitative reverse transcriptase PCR (RQ-PCR) and immunohistochemistry (IHC). The effects of intraperitoneal adeno-associated virus-Tβ4 (AAV-Tβ4) on CCl4 -induced hepatic fibrosis were observed through the evaluation of collagen deposition, hepatic stellate cell (HSC) activation and pro-fibrotic cytokine expression...
July 4, 2018: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29972605/concentrations-of-immune-marker-in-newborn-dried-blood-spots-and-early-childhood-development-results-from-the-upstate-kids-study
#13
Akhgar Ghassabian, Rajeshwari Sundaram, Nikhita Chahal, Alexander C McLain, Erin M Bell, David A Lawrence, Stephen E Gilman, Edwina H Yeung
BACKGROUND: Evidence shows cytokine dysregulation in children with developmental disabilities. The association between immune activity during the perinatal period and child development is less clear. METHODS: We examined the relationship between newborn concentrations of immune markers and child development. Within Upstate KIDS, a population-based birth cohort (2008-2010, upstate New York), we assayed immune markers, which are postulated to have neuro-modulatory effects, in newborn dried blood spots (NDBS, n = 3038)...
July 4, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29966370/the-genomics-and-molecular-biology-of-natural-killer-t-cell-lymphoma-opportunities-for-translation
#14
REVIEW
Sanjay de Mel, Gwyneth Shook-Ting Soon, Yingting Mok, Tae-Hoon Chung, Anand D Jeyasekharan, Wee-Joo Chng, Siok-Bian Ng
Extranodal NK/T-cell lymphoma, nasal type (ENKTL), is an aggressive malignancy with a poor prognosis. While the introduction of L-asparaginase in the treatment of this disease has significantly improved the prognosis, the outcome of patients relapsing after asparaginase-based chemotherapy, which occurs in up to 50% of patients with disseminated disease, remains dismal. There is hence an urgent need for effective targeted therapy especially in the relapsed/refractory setting. Gene expression profiling studies have provided new perspectives on the molecular biology, ontogeny and classification of ENKTL and further identified dysregulated signaling pathways such as Janus associated kinase (/Signal Transducer and activation of transcription (JAK/STAT), Platelet derived growth factor (PDGF), Aurora Kinase and NF-κB, which are under evaluation as therapeutic targets...
June 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29963188/effects-of-endometrial-stem-cell-transplantation-combined-with-estrogen-in-the-repair-of-endometrial-injury
#15
Xinrong Wang, Hongchu Bao, Xuemei Liu, Chengde Wang, Cuifang Hao
The present study investigated the effects of endometrial stem cell (EnSCs) transplantation combined with estrogen in the repair of endometrial injury. A total of 30 patients with intrauterine adhesions (IUA) and 30 healthy individuals were selected. Expression of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF)-BB in endometrial tissue was assessed. Additionally, expression levels of epithelial membrane antigen (EMA), cytokeratin (CK), integrin α-6 (CD49f), Thy-1 membrane glycoprotein (THY-1), collagen type 1 (Col I), fibroblast (5B5) and vimentin in EnSCs were detected using western blot analysis and reverse transcription-quantitative polymerase chain reaction...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29961751/effects-of-3-tetrazolyl-methyl-3-hydroxy-oxindole-hybrid-thoh-on-cell-proliferation-apoptosis-and-g2-m-cell-cycle-arrest-occurs-by-targeting-platelet-derived-growth-factor-d-pdgf-d-and-the-mek-erk-signaling-pathway-in-human-lung-cell-lines-sk-lu-1-a549-and
#16
Peng Li, Zhiqiang Zhang, Feng Zhang, Hongling Zhou, Bei Sun
BACKGROUND The aim of this study was to evaluate the effects of 3-tetrazolyl methyl-3-hydroxy-oxindole hybrid (THOH) on cell proliferation, apoptosis, and the cell cycle in human lung cancer cell lines SK-LU-1, A549, and A-427, and the normal lung fibroblast cell line, MRC-5, in vitro. MATERIAL AND METHODS Human lung adenocarcinoma cells SK-LU-1, A549, and A-427, and the normal lung fibroblast cells, MRC-5 were cultured and treated with increasing concentrations of 10 mM of a stock solution of THOH in dimethyl sulfoxide (DMSO)...
July 2, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29956736/reversal-of-the-warburg-effect-with-dca-in-pdgf%C3%A2-treated-human-pasmc-is-potentiated-by-pyruvate-dehydrogenase-kinase%C3%A2-1-inhibition-mediated-through-blocking-akt-gsk%C3%A2-3%C3%AE-signalling
#17
Bingbing Li, Yuling Zhu, Qing Sun, Chunfang Yu, Lian Chen, Yali Tian, Jie Yan
There is accumulating evidence indicating that the growth inhibitory effect of dichloroacetate (DCA) on pulmonary arterial smooth muscle cells (PASMCs) may be associated with the reversal of the Warburg effect and initiation of the mitochondria‑dependent apoptotic pathway. Previous studies indicated that platelet‑derived growth factor (PDGF) promoted the Warburg effect and resulted in apoptotic resistance of PASMCs, which was attributed to activation of the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) signalling pathway...
June 27, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29955127/nanosphere-mediated-co-delivery-of-vegf-a-and-pdgf-b-genes-for-accelerating-diabetic-foot-ulcers-healing-in-rats
#18
Rongfeng Shi, Weishuai Lian, Shilong Han, Chuanwu Cao, Yinpeng Jin, Yifeng Yuan, Hui Zhao, Maoquan Li
Diabetic ischemic ulcer is an intractable diabetic complication. Angiogenesis is a critical factor for wound healing in patients with diabetic foot wounds. Sustained gene delivery could be notably necessary in modulating gene expression in chronic ulcer healing and might be a promising approach for diabetic foot ulcers. In the present study, Sprague-Dawley rats were used to establish diabetic foot ulcer models by streptozotocin and skin biopsy punch. The plasmids expressing VEGF-A and PDGF-B were prepared and then incorporated with polylactic-co-glycolic acid (PLGA) nanospheres to upregulate genes expression...
June 28, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29953880/diabetex-a-novel-approach-for-diabetic-wound-healing
#19
Alshaymaa Amin Zaki El-Bahy, Yara Mohamed Aboulmagd, Mohanad Zaki
INTRODUCTION AND AIM: Wound healing is an orderly complex process involving inflammation, clotting, re-epithelialization, neovascularization and wound closure. In diabetic patients, such process is impaired and delayed, posing negative economic as well as social consequences. Diabetex, (patency# EP 0877617 A1) composed of L-alanine, d-ribose, nicotinic acid and calcium ascorbate, which was initially introduced to treat cancer is thought to have anti- diabetic effects. The present study was designed to investigate the therapeutic merit of diabetex as well as the cellular mechanisms involved in such effects and its safety profile compared to metformin in wounded diabetic rats...
June 25, 2018: Life Sciences
https://www.readbyqxmd.com/read/29951536/oxidation-prevents-hmgb1-inhibition-on-pdgf-induced-differentiation-of-multipotent-vascular-stem-cells-to-smooth-muscle-cells-a-possible-mechanism-linking-oxidative-stress-to-atherosclerosis
#20
Xiaohu Meng, Wenjie Su, Xuan Tao, Mingyang Sun, Rongchao Ying, Wei Wei, Baolin Wang
Atherosclerosis is considered as a multifactorial disease in terms of the pathogenic mechanisms. Oxidative stress has been implicated in atherogenesis, and the putative mechanisms of its action include oxidative modification of redox-sensitive signaling factors. High mobility group box 1 (HMGB1) is a key inflammatory mediator in atherosclerosis, but if oxidized it loses its activity. Thus, whether and how it participates in oxidative stress-induced atherosclerosis are not clear. The current study found that exogenous HMGB1 dose-dependently inhibited the proliferation of multipotent vascular stem cells and their differentiation to smooth muscle cells induced by platelet-derived growth factor...
2018: BioMed Research International
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