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syringomatous carcinoma

Bipasha Mukherjee, Nirmala Subramaniam, Krishna Kumar, Pratheeba Devi Nivean
Microcystic adnexal carcinoma (MAC) is a rare malignancy of sweat glands that has been reported most often on the face in the form of a cutaneous lesion, with the potential for deeper invasion. The synonyms of MAC include sclerosing sweat duct carcinoma, syringomatous carcinoma, and malignant syringoma. Clinically, MAC in the periocular area has been misdiagnosed as basal cell carcinoma, squamous cell carcinoma, or even chalazia. We report a case of MAC presenting clinically as sebaceous gland carcinoma with pagetoid spread for the first time in literature...
October 20, 2017: Orbit
D Tacchini, L Vassallo, M A G M Butorano, V Mancini, T Megha
Papillary breast lesions are a heterogeneous group of tumors which mainly arise in the central mammary region, ranging from benign to malignant. Among them, solid papillary carcinoma (SPC) represents a very uncommon variant with indolent clinical behavior and excellent prognosis. The categorization of papillary lesions as benign, atypical or malignant is often difficult even for experienced pathologists. Furthermore, for prognostic purposes, to decide whether to consider a lesions as in situ when it is not associated with frank invasive foci of carcinoma may be problematic...
September 2016: Pathologica
Eri Katayama, Hiroshi Saruta, Aya Nanri, Takekuni Nakama, Chika Ohata
Syringomatous carcinoma (SC) is a slow-growing malignant skin tumor that usually affects the face or scalp. An 83-year-old female developed SC on the sole, a rare location. Histopathologically, numerous ducts with few keratinizing cysts were seen in the upper dermis, and cords, strands and nests with sclerotic stroma were seen in the deep dermis and subcutis. In addition to the perineural and intraneural invasion of the tumor, the tumor cells had also invaded the vessel walls. There was no intravasation of tumor cells or interruption of the endothelium...
April 2017: Journal of Cutaneous Pathology
Anastasia M Konstantinova, Malcolm M Hayes, Colin J R Stewart, Jose A Plaza, Michal Michal, Katrin Kerl, Dmitry V Kazakov
Primary extramammary Paget disease (EMPD) is a form of intraepithelial adenocarcinoma. Different morphological changes may accompany EMPD, including the presence of syringoma-like structures. The authors report 10 cases of EMPD, all of which manifested syringoma-like structures within the dermis both in areas involved by the carcinoma and beyond, including at the margins of the excisions. All patients were women, whose ages ranged from 49 to 93 years (median 75 years). The possible pathogenesis of the syringoma-like lesions is discussed...
September 2016: American Journal of Dermatopathology
Deborah A Dillon, Susan C Lester
Because of the singular anatomic structure of the nipple, some breast lesions only occur at this site. The overlying skin includes normal Toker cells near the duct orifices. These cells are occasionally so numerous as to be called Toker cell hyperplasia. Ductal carcinoma in situ (DCIS) may involve nipple skin by direct extension from the underlying ducts (Paget disease of the nipple). The numerous skin appendages (eg, sebaceous, apocrine, and eccrine glands(1)) in the nipple and areola are the likely origin of syringomatous adenomas...
June 2009: Surgical Pathology Clinics
Timothy M D'Alfonso, Sandra J Shin
This article discusses the most common small glandular proliferations, namely sclerosing lesions (sclerosing adenosis and radial scar), tubular carcinoma, and epithelial displacement after needle core biopsy, as well as less common entities, such as low-grade adenosquamous carcinoma, microglandular adenosis, and syringomatous adenoma. Due to significant morphologic overlap, these entities are easily mistaken for one another. The similarities and differences among these lesions in their clinicopathologic features, radiologic findings, and immunohistochemical profiles are emphasizesd...
September 2012: Surgical Pathology Clinics
J L Senger, P Meiers, R Kanthan
INTRODUCTION: Low-grade adenosquamous carcinoma (LGASC) is a rare, unique variant of metaplastic breast carcinoma, characterized by clinical indolence and low-grade cytomorphology. Being clinically asymptomatic with indefinite imaging characteristics, diagnosis is solely dependent on histopathology. PRESENTATION OF CASE: A 68-year-old woman presented to the Breast Health Center with mammogram-detected left-sided retroareolar calcifications. She had a three-year history of non-progressive bilateral nipple inversion, and was otherwise asymptomatic...
2015: International Journal of Surgery Case Reports
Caterina Longo, Moira Ragazzi, Stefano Gardini, Elvira Moscarella, Giuseppe Argenziano
No abstract text is available yet for this article.
September 2015: JAMA Dermatology
E Frouin, M D Vignon-Pennamen, B Balme, B Cavelier-Balloy, U Zimmermann, N Ortonne, A Carlotti, L Pinquier, J André, B Cribier
BACKGROUND: Microcystic adnexal carcinoma (MAC), syringomatous carcinoma (SC) and "Squamoid eccrine ductal carcinoma" (SEDC) are rare sclerosing adnexal tumours. OBJECTIVE: To understand the histogenesis of these tumours and possible clinical implications. METHODS: We conducted a retrospective study of 30 cases, 18 MAC, 5 SC and 7 SEDC reviewed and classified by a panel of dermatopathology experts, with immunohistochemical analysis of keratins, including K77, a new keratin specific of eccrine ducts, and PHLDA1 expressed in adnexal structures...
October 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
Werner Boecker, Göran Stenman, Thomas Loening, Mattias K Andersson, Tobias Berg, Alina Lange, Agnes Bankfalvi, Vera Samoilova, Katharina Tiemann, Igor Buchwalow
A small group of tumors of breast and salivary glands contains squamous/epidermoid elements as a constitutive feature (e.g., squamous carcinoma, syringomatous tumors, and mucoepidermoid carcinoma). Other tumors (e.g., pleomorphic adenoma, adenomyoepithelial tumors, and adenoid cystic carcinoma) may show occasionally squamous differentiation. Furthermore, squamous metaplasia may be observed in non-neoplastic breast and salivary tissues. However, the histogenesis of these squamous differentiations is far from being understood...
January 2015: Virchows Archiv: An International Journal of Pathology
Nathan D Montgomery, Gregory D Bianchi, Nancy Klauber-Demore, Debra A Budwit
OBJECTIVES: Syringomatous adenoma of the nipple (SAN) is a rare benign infiltrative neoplasm that may be confused with low-grade breast carcinomas. We report the case of 71-year-old woman with a fungating left breast mass and subareolar calcifications in the contralateral breast. METHODS: Histomorphologic features were evaluated with standard H&E-stained sections. Both lesions were also evaluated by immunohistochemistry for further characterization. A literature review was performed to place the current case in context relative to previous observations...
May 2014: American Journal of Clinical Pathology
Suryasnata Rath, Bryce J Cowan, Peter J Dolman
A 41-year-old woman previously diagnosed with generalized eruptive keratoacanthomas of Grzybowski type presented with bilateral lower eyelid cicatrical ectropions. She had previously undergone multiple resections of syringomatous adenomas of both nipples, facial keratoacanthomas, and a lower left lip squamous cell carcinoma. Her facial and periocular skin was thickened with a cobblestone appearance. Cicatricial ectropions involved both upper and lower eyelids. Donor skin was harvested from the dorsum of the foot as this was the only disease-free area on her body, and she achieved a stable result with reduced tearing and improved appearance...
March 2014: Ophthalmic Plastic and Reconstructive Surgery
Felipe Fornias Sperandio, Fernanda Salgueiredo Giudice, Décio Dos Santos Pinto-Junior, Suzana Cantanhede Orsini Machado de Sousa
BACKGROUND: Myoepitheliomas are rare tumours that may generally arise from the minor or major salivary glands. The differential diagnosis of this tumour should be performed along with several benign and malignant soft tissue neoplasms. The present case report describes an asymptomatic mass that arose in the soft palate of 42 year old black woman with duration of the six months. METHODS: An incisional biopsy of soft palate lesion was carried out and submitted for histological evaluation under the clinical hypothesis of salivary gland tumour...
2011: Journal of Oral & Maxillofacial Research
Werner Boecker, Göran Stenman, Thomas Loening, Mattias K Andersson, Hans-Peter Sinn, Peter Barth, Felix Oberhellmann, Inge Bos, Tobias Berg, Zlatko Marusic, Vera Samoilova, Igor Buchwalow
AIMS: Syringomatous tumour of the nipple and low-grade adenosquamous carcinoma (LGAdSC) of the breast are regarded as distinct entities. To clarify the nature of these two lesions, we compared the expression of different lineage/differentiation markers in 12 syringomatous tumours of the nipple, nine LGAdSCs, and normal breast epithelium. METHODS AND RESULTS: Using triple immunofluorescence labelling and quantitative RT-PCR for keratins, p63, and smooth muscle actin, we demonstrated that syringomatous tumour and LGAdSC contain p63+/K5/14+ tumour cells, K10+ squamous cells, and K8/18+ glandular cells, with intermediary cells being found in both lineages...
July 2014: Histopathology
Markus D Boos, Rosalie Elenitsas, John Seykora, Michael S Lehrer, Christopher J Miller, Joseph Sobanko
Microcystic adnexal carcinoma (MAC) is an uncommon, locally aggressive, malignant cutaneous tumor with pilar and eccrine differentiation. Mohs micrographic surgery is the treatment of choice for this condition, but specific histological findings can complicate MAC removal and leave doubt as to whether the tumor has been completely removed. Here we describe the clinical and pathological characteristics of a case in which a patient with an MAC underwent multiple reexcisions because of the presence of benign subclinical syringomatous proliferations adjacent to the primary lesion...
February 2014: American Journal of Dermatopathology
Basma El khannoussi, Hajar Hechlaf, Issam Lalya, Mohamed Oukabli, Abderrahman Al Bouzidi, Nicolas Ortonne
Syringomatous carcinoma is a rare cutaneous neoplasm, most frequently situated on the face and scalp and histologically characterised by an infiltrative pattern of basaloid or squamous cells, a desmoplastic stromal reaction and keratin filled cysts. We report the case of a 76-year-old woman who presented an ulcerative interscapular lesion measuring 3x4cm. After resection, the histological examinations of the specimens have identified a basal cell carcinoma. However, a local recurrence was observed 18 months later; histopathological findings showed a syringomatous pattern and neoplastic epithelial cells arranged in interconnecting cords with microcystic areas...
2012: Pan African Medical Journal
Jing Li, Guang-zhi Yang, Hua Jin, Hua-ye Ding
OBJECTIVE: To investigate the pathologic and immunohistochemical features, diagnosis and differential diagnosis of low-grade adenosquamous carcinoma of the breast and syringomatous adenoma of the nipple. METHODS: Six cases of low-grade adenosquamous carcinoma of the breast and four cases of syringomatous adenoma of the nipple were examined histologically and immunohistochemically (MaxVision method), and the literature was reviewed. RESULTS: The two types of tumors were similar in morphology, but located in different regions with low-grade adenosquamous carcinoma being present in the deep parenchyma and syringomatous adenoma in nipple...
May 2012: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Christine A Liang, Klaus J Busam, Kishwer S Nehal
No abstract text is available yet for this article.
October 2011: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Deba P Sarma, Todd Stevens
BACKGROUND: Differential diagnosis for a nodule in the nipple or subareolar area of woman includes both primary neoplasms of breast as well as those from skin and adnexae. CASE PRESENTATION: A 32-year-old woman presented with a painless 0.5 cm subareolar nodule of her left nipple that she had noticed for several months, with no associated nipple discharge. A biopsy revealed an infiltrating adnexal neoplasm with features similar to those seen in syringomas commonly occurring in locations such as upper face and pubis...
2009: Cases Journal
Khine Z Oo, Philip Q Xiao
Infiltrating syringomatous adenoma of the nipple is a rare neoplasm of the breast. Syringomatous adenoma of the nipple is often misdiagnosed because clinical examination and mammographic findings of syringomatous adenoma of the nipple mimic carcinoma. Despite its benign behavior, syringomatous adenoma of the nipple usually shows infiltrative expansile proliferation into adjacent tissue and underlying breast tissue. Up until now, to our knowledge, there has been no reported case of regional or distant metastasis...
September 2009: Archives of Pathology & Laboratory Medicine
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