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https://www.readbyqxmd.com/read/27936218/a-key-role-for-inhibins-in-dendritic-cell-maturation-and-function
#1
Roxana Olguín-Alor, Marisol de la Fuente-Granada, Laura C Bonifaz, Laura Antonio-Herrera, Eduardo A García-Zepeda, Gloria Soldevila
Inhibins are members of the TGFβ superfamily, which regulate many cellular processes including differentiation, proliferation, survival and apoptosis. Although initially described as hormones regulating the hypothalamus-pituitary-gonadal axis, based on their ability to antagonize Activins, our group has recently reported that they play a role in thymocyte differentiation and survival, as well as in thymic stromal cell maturation and nTreg generation. Here, we used Inhibin knock out mice (Inhα-/-) to investigate the role of Inhibins in peripheral dendritic cell maturation and function...
2016: PloS One
https://www.readbyqxmd.com/read/27935981/sympathetic-hyperactivity-increased-tyrosine-hydroxylase-and-exaggerated-corpus-cavernosum-relaxations-associated-with-oxidative-stress-plays-a-major-role-in-the-penis-dysfunction-in-townes-sickle-cell-mouse
#2
Fábio H Silva, Mário A Claudino, Fabiano B Calmasini, Eduardo C Alexandre, Carla Franco-Penteado, Arthur L Burnett, Edson Antunes, Fernando F Costa
BACKGROUND: Sickle cell disease patients display priapism that may progress to erectile dysfunction. However, little is known about the pathophysiological alterations of corpus cavernosum in sickle cell disease. OBJECTIVE: Thus, this study aimed to evaluate the functional and molecular alterations of sympathetic machinery and nitric oxide-cyclic guanosine monophosphate signaling pathway in Townes transgenic sickle cell disease mice. METHODS: Concentration-response curves to contractile (phenylephrine) and relaxant agents (acetylcholine and sodium nitroprusside) were obtained in corpus cavernosum strips from sickle and C57BL/6 (control) mice...
2016: PloS One
https://www.readbyqxmd.com/read/27933691/single-fusion-events-at-polarized-liquid-liquid-interfaces
#3
Eduardo Laborda, Angela Molina, Vanesa Fernández Espín, Francisco Martínez-Ortiz, José García de la Torre, Richard G Compton
A new electrochemical framework for tracking individual soft particles in solution and monitoring their fusion with polarized liquid-liquid interfaces is reported. The physicochemical principle lies in the interfacial transfer of an ionic probe confined in the particles dispersed in solution and that is released upon their collision and fusion with the fluid interface. As a proof-of-concept, spike-like transients of a stochastic nature are reported in the current-time response of 1,2-dichloroethane(DCE)|water(W) submilli-interfaces after injection of DCE-in-W emulsions...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27933479/-bunch-of-grapes-in-complete-hydatidiform-mole
#4
REVIEW
Eduardo Kaiser Ururahy Nunes Fonseca, Marina Athaniel Silva Rodrigues, Fernando Ide Yamauchi, Ronaldo Hueb Baroni
Complete hydatidiform mole is a common cause of gestational bleeding of the first trimester, commonly assessed by ultrasound. It represents an abnormal proliferation of trophoblastic tissue, with no fetal formation, just hydropic villi. These abnormal villi seen in ultrasound are compared to a "bunch of grapes," a classic description of this disease.
December 8, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27933457/pristine-but-metal-rich-r%C3%A3-o-sucio-dirty-river-is-dominated-by-gallionella-and-other-iron-sulfur-oxidizing-microbes
#5
Alejandro Arce-Rodríguez, Fernando Puente-Sánchez, Roberto Avendaño, Eduardo Libby, Leonardo Rojas, Juan Carlos Cambronero, Dietmar H Pieper, Kenneth N Timmis, Max Chavarría
Whether the extreme conditions of acidity and heavy metal pollution of streams and rivers originating in pyritic formations are caused primarily by mining activities or by natural activities of metal-oxidizing microbes living within the geological formations is a subject of considerable controversy. Most microbiological studies of such waters have so far focused on acid mine drainage sites, which are heavily human-impacted environments, so it has been problematic to eliminate the human factor in the question of the origin of the key metal compounds...
December 8, 2016: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/27933440/modern-role-of-clinical-ultrasound-in-liver-abscess-and-echinococcosis
#6
REVIEW
Rita Barosa, João Pinto, Ana Caldeira, Eduardo Pereira
In the Western world, liver abscesses are predominantly of pyogenic origin and can present a wide range of ultrasonographic features, from a solid mass to a cystic cavity. Amoebic abscesses are endemic in tropical areas and typically round single lesions. Echinococcal cyst is diagnosed by ultrasound (US). Serology is particularly useful when pathognomonic US features are absent. Treatment is determined based on the WHO ultrasonographic classification, and puncture, aspiration, injection, re-aspiration (PAIR) is a US-guided therapeutic option...
December 8, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27933063/aire-downregulation-is-associated-with-changes-in-the-posttranscriptional-control-of-peripheral-tissue-antigens-in-medullary-thymic-epithelial-cells
#7
Ernna H Oliveira, Claudia Macedo, Cristhianna V Collares, Ana Carolina Freitas, Paula Barbim Donate, Elza T Sakamoto-Hojo, Eduardo A Donadi, Geraldo A Passos
Autoimmune regulator (Aire) is a transcriptional regulator of peripheral tissue antigens (PTAs) and microRNAs (miRNAs) in medullary thymic epithelial cells (mTECs). In this study, we tested the hypothesis that Aire also played a role as an upstream posttranscriptional controller in these cells and that variation in its expression might be associated with changes in the interactions between miRNAs and the mRNAs encoding PTAs. We demonstrated that downregulation of Aire in vivo in the thymuses of BALB/c mice imbalanced the large-scale expression of these two RNA species and consequently their interactions...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27932994/comparative-mrna-and-microrna-profiling-during-acute-myocardial-infarction-induced-by-coronary-occlusion-and-ablation-radio-frequency-currents
#8
Eduardo T Santana, Regiane Dos Santos Feliciano, Andrey J Serra, Eduardo Brigidio, Ednei L Antonio, Paulo J F Tucci, Lubov Nathanson, Mariana Morris, José A Silva
The ligation of the left anterior descending coronary artery is the most commonly used experimental model to induce myocardial infarction (MI) in rodents. A high mortality in the acute phase and the heterogeneity of the size of the MI obtained are drawbacks recognized in this model. In an attempt to solve the problem, our group recently developed a new MI experimental model which is based on application of myocardial ablation radio-frequency currents (AB-RF) that yielded MI with homogeneous sizes and significantly reduce acute mortality...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27932981/proton-pump-inhibitors-display-antitumor-effects-in-barrett-s-adenocarcinoma-cells
#9
Eduardo Chueca, Nadezda Apostolova, Juan V Esplugues, María A García-González, Ángel Lanas, Elena Piazuelo
Recent evidence has reported that proton pump inhibitors (PPIs) can exert antineoplastic effects through the disruption of pH homeostasis by inhibiting vacuolar ATPase (H(+)-VATPase), a proton pump overexpressed in several tumor cells, but this aspect has not been deeply investigated in EAC yet. In the present study, the expression of H(+)-VATPase was assessed through the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's esophagus (BE) and the antineoplastic effects of PPIs and cellular mechanisms involved were evaluated in vitro...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27932616/modified-profile-of-matrix-metalloproteinase-2-and-9-production-by-human-fallopian-tube-epithelial-cells-following-infection-in-vitro-with-neisseria-gonorrhoeae
#10
Paula I Rodas, Doris Pérez, Claudia Jaffret, Yaquelin González, Carolina Carreño, Cecilia V Tapia, Eduardo Osorio, Luis A Velasquez, Myron Christodoulides
Epithelial shedding and scarring of Fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and likely involves an imbalance of host extracellular matrix components (ECM) and their regulators such as matrix metalloproteinases (MMPs). In this brief report, primary human Fallopian tube epithelial cells were infected with N. gonorrhoeae and MMP patterns examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed...
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27932292/graduated-compression-stockings-does-not-decrease-walking-capacity-and-muscle-oxygen-saturation-during-six-minute-walk-test-in-intermittent-claudication-patients
#11
Bruno Remígio Cavalcante, Raphael Mendes Ritti-Dias, Antônio Henrique Germano Soares, Wagner Jorge Ribeiro Domingues, Glauco Fernandes Saes, Flávio Henrique Duarte, Aline de Paula da Cruz, Nelson Wolosker, Pedro Puech-Leão, Gabriel Grizzo Cucato, Antonio Eduardo Zerati
BACKGROUND: We analyze the effects of graduated compression stoking (GCS) on walking capacity and oxygen saturation in intermittent claudication (IC) patients. METHODS: Eighteen patients with IC performed the six-minute walking test in two conditions in random order: GCS or placebo sock. Onset claudication distance and total walking distance were obtained. The calf muscle oxygen saturation was continuously monitored before, during and after six-minute walk test...
December 5, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27931932/susceptibility-of-rhipicephalus-boophilus-microplus-to-fluazuron-2-5mg-kg-and-a-combination-of-novaluron-2-0mg-kg-eprinomectin-0-36mg-kg-in-field-studies-in-brazil
#12
Willian Giquelin Maciel, Welber Daniel Zanetti Lopes, Lucas Vinicius Costa Gomes, Breno Cayeiro Cruz, Gustavo Felippelli, Isabella Barbosa Dos Santos, Fernando de Almeida Borges, Walter Antonio Gonçalves, Alexandre Braga Scarpa, João Eduardo Nicaretta, Thiago Souza Azeredo Bastos, Alvimar José da Costa
The present study aimed to determine the susceptibility of 32 R. (B.) microplus populations from Southeast, Midwest and South regions of Brazil, to fluazuron (2.5mg/kg), administered topically (pour-on). Additionally, five populations (Southeast and Midwest regions) of the southern cattle tick were evaluated using in vivo field studies, regarding their susceptibility to a new combination of novaluron (2.0mg/kg)+eprinomectin (0.36mg/kg), administered subcutaneously, compared with two positive controls (fluazuron 2...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27931930/urban-dogs-in-rural-areas-human-mediated-movement-defines-dog-populations-in-southern-chile
#13
Federico J Villatoro, Maximiliano A Sepúlveda, Paulina Stowhas, Eduardo A Silva-Rodríguez
Management strategies for dog populations and their diseases include reproductive control, euthanasia and vaccination, among others. However, the effectiveness of these strategies can be severely affected by human-mediated dog movement. If immigration is important, then the location of origin of dogs imported by humans will be fundamental to define the spatial scales over which population management and research should apply. In this context, the main objective of our study was to determine the spatial extent of dog demographic processes in rural areas and the proportion of dogs that could be labeled as immigrants at multiple spatial scales...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27931132/guillain-barr%C3%A3-syndrome-during-adalimumab-therapy-for-crohn%C3%A2-s-disease-coincidence-or-consequence
#14
Guilherme Grossi Lopes Cançado, Eduardo Garcia Vilela
We report the case of a 64-year-old patient diagnosed with extensive ileal Crohn´s disease who developed Guillain-Barré syndrome after starting biological therapy with adalimumab. Neurologic involvement associated with inflammatory bowel diseases is recognized as an extra-intestinal manifestation. After the breakthrough of antitumor necrosis factor alpha (anti-TNF-α) agents, an increasing number of cases of acute inflammatory demyelinating polyneuropathies have been reported; however, only one case has been described in a patient with Crohn´s disease...
December 8, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27931106/gastric-schwannoma-presenting-as-a-casual-ultrasonographic-findings
#15
Francisco Javier Álvarez Higueras, Ana Pereñíguez López, Esther Estrella Díez, María Muñoz Tornero, Juan Egea Valenzuela, Águeda Bas Bernal, Carmen Garre Sánchez, Ángel Vargas Acosta, Eduardo Sánchez Velasco, Luis Fernando Carballo Álvarez
We present the case of a patient under study due to ascites in which a mass located on the gastric wall was observed during ultrasonography. Further studies (upper endoscopy and computed tomography) confirmed this finding. After an ultrasound-guided percutaneous biopsy, diagnosis of gastric schwannoma was made as intense S-100 expression was found. Surgery was rejected due to the bad clinical situation of the patient and because the mass was an asymptomatic benign tumor.
December 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27930736/analysis-of-a-smartphone-based-architecture-with-multiple-mobility-sensors-for-fall-detection
#16
Eduardo Casilari, Jose Antonio Santoyo-Ramón, Jose Manuel Cano-García
During the last years, many research efforts have been devoted to the definition of Fall Detection Systems (FDSs) that benefit from the inherent computing, communication and sensing capabilities of smartphones. However, employing a smartphone as the unique sensor in a FDS application entails several disadvantages as long as an accurate characterization of the patient's mobility may force to transport this personal device on an unnatural position. This paper presents a smartphone-based architecture for the automatic detection of falls...
2016: PloS One
https://www.readbyqxmd.com/read/27930650/a-historic-report-of-zika-in-mozambique-implications-for-assessing-current-risk
#17
Eduardo Samo Gudo, Kerstin I Falk, Sadia Ali, Argentina Felisbela Muianga, Vanessa Monteiro, Julie Cliff
No abstract text is available yet for this article.
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27930404/sandwich-osteotomies-to-treat-vertical-defects-of-the-alveolar-ridge
#18
Claudio Ferreira Nóia, Rafael Ortega-Lopes, Leandro Eduardo Kluppel, Bruno Costa Martins de Sá
PURPOSE: To evaluate the vertical bone gain after osteotomy sandwich. MATERIALS AND METHODS: Fourteen patients (mean age, 41 years) underwent 17 procedures of osteotomy sandwich. Of these 17 procedures, 15 involved reconstructive surgery and 2 involved the repositioning of implants. The patients were submitted to computed tomography before the surgical procedure and 4 months after the completion of the graft, with measurements taken to assess the vertical gain that had been achieved...
December 7, 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27929741/cerebral-microvascular-dysfunction-and-inflammation-are-improved-by-centrally-acting-antihypertensive-drugs-in-metabolic-syndrome
#19
Vanessa Estato, Alessandro Nascimento, Barbara Antunes, Fabiana Gomes, Laura Coelho, Raquel Rangel, Luciana Garzoni, Anissa Daliry, Pascal Bousquet, Eduardo Tibiriçá
BACKGROUND: We aimed to investigate the effects of chronic oral treatment with centrally acting antihypertensive drugs, such as clonidine (CLO), an α2-adrenoceptor agonist, or LNP599, a selective I1 imidazoline receptor agonist, on brain microvascular function in rats with high-fat diet (HFD)-induced metabolic syndrome. METHODS: Male Wistar Kyoto rats were maintained on a normal diet (CON) or a HFD for 20 weeks. After this period, the HFD group received oral CLO (0...
December 8, 2016: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/27929586/new-methods-general-discussion
#20
Gonzalo Angulo, Raymond Dean Astumian, Vijay Beniwal, Peter G Bolhuis, Christoph Dellago, John Ellis, Bernd Ensing, David R Glowacki, Sharon Hammes-Schiffer, Johannes Kästner, Tony Lelièvre, Nancy Makri, David Manolopoulos, Georg Menzl, Thomas F Miller, Adrian Mulholland, Ewa Anna Oprzeska-Zingrebe, Michele Parrinello, Eli Pollak, Jonny Proppe, Markus Reiher, Jeremy Richardson, Priyadarshi Roy Chowdhury, Eduardo Sanz, Christof Schütte, Dmitry Shalashilin, Rafał Szabla, Srabani Taraphder, Ambuj Tiwari, Eric Vanden-Eijnden, Adithya Vijaykumar, Kirill Zinovjev
No abstract text is available yet for this article.
December 8, 2016: Faraday Discussions
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