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https://www.readbyqxmd.com/read/28449209/the-frequency-of-qtc-prolongation-among-pediatric-and-young-adult-patients-receiving-methadone-for-cancer-pain
#1
Kevin Madden, Minjeong Park, Diane Liu, Eduardo Bruera
INTRODUCTION: A prolonged corrected QT (QTc) interval in pediatric patients is defined as ≥470 msec. Methadone can cause a prolonged QTc interval that can lead to ventricular arrhythmias. The risk of methadone-induced prolongation of the QTc interval in children and young adults is unknown. The purpose of the study was to determine the frequency of QTc prolongation among pediatric and young adult patients with cancer pain on methadone treatment. METHODS: We retrospectively reviewed data for all patients on methadone during the study period...
April 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28449130/response-to-the-letter-to-the-editor-from-maddafari-et-al-about-reappraisal-and-new-observations-on-atrial-tachycardia-ablated-from-the-non-coronary-aortic-sinus-of-valsalva
#2
Shomu Bohora, Yash Lokhandwala, Eduardo Back Sternick, Robert H Anderson, Hein J J Wellens
No abstract text is available yet for this article.
April 24, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28449038/real-time-imaging-of-single-neuronal-cell-apoptosis-in-patients-with-glaucoma
#3
Maria F Cordeiro, Eduardo M Normando, M Jorge Cardoso, Serge Miodragovic, Seham Jeylani, Benjamin M Davis, Li Guo, Sebastien Ourselin, Roger A'Hern, Philip A Bloom
Retinal cell apoptosis occurs in many ocular neurodegenerative conditions including glaucoma-the major cause of irreversible blindness worldwide. Using a new imaging technique that we have called DARC (detection of apoptosing retinal cells), which until now has only been demonstrated in animal models, we assessed if annexin 5 labelled with fluorescent dye DY-776 (ANX776) could be used safely in humans to identify retinal cell apoptosis. Eight patients with glaucomatous neurodegeneration and evidence of progressive disease, and eight healthy subjects were randomly assigned to intravenous ANX776 doses of 0...
April 26, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28448938/choice-modeling-of-system-wide-or-large-scale-environmental-change-in-a-developing-country-context-lessons-from-the-para%C3%A3-ba-do-sul-river
#4
James R Kahn, William F Vásquez, Carlos Eduardo de Rezende
The Rio Paraiba do Sul is a highly polluted river in south central Brazil, that is contaminated by industrial, agricultural and municipal wastes, as well as being impacted by dams, water withdrawals and deforestation in the watershed. Since only very intensive and farreaching environmental policies could result in water quality improvements, valuing the restoration of the river presents many unique challenges. We develop a choice-modeling approach to valuation of the restoration of this river, with general tightening of environmental policy as the policy, and an increase in prices as the payment vehicle...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448845/use-of-aqueous-two-phase-peg-salt-systems-for-the-removal-of-anionic-surfactant-from-effluents
#5
Gabriella Frade Murari, Jussara Alves Penido, Heriveltom Morais da Silva, Bruno Eduardo Lôbo Baêta, Sérgio Francisco de Aquino, Leandro Rodrigues de Lemos, Guilherme Dias Rodrigues, Aparecida Barbosa Mageste
Linear alkylbenzene sulfonates (LAS) are synthetic anionic surfactants that are extensively used in many industries. As a result, large volumes of effluents containing high levels of these compounds are discharged into water bodies, causing risks to aquatic flora and fauna. Then, there is a need for environmentally safe and economically viable technologies for the removal of LAS from aqueous matrices. The present work evaluates the use of aqueous two-phase systems (ATPS) composed of PEG and sulfate salts for this purpose, considering the effects of tie line length (TLL), molar mass of polymer, and type of cation-forming salt on the partitioning behavior of LAS...
April 24, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28448570/disease-burden-for-patients-with-primary-immunodeficiency-diseases-identified-at-reference-hospitals-in-guanajuato-mexico
#6
Eduardo Guaní-Guerra, Ana Isabel Jiménez-Romero, Ulises Noel García-Ramírez, José Manuel Velázquez-Ávalos, Edgar Martínez-Guzmán, Eunice Sandoval-Ramírez, Ignacio Camacho-Meza
BACKGROUND: In addition to the deleterious effect on health, there is considerable economic and psychosocial morbidity associated with primary immunodeficiency diseases (PID). Also, the cost of a late diagnosis frequently results in a heavy disease burden on the patient. The objective of this study was to collect and analyze data on patients with PID in the state of Guanajuato in Mexico, to indirectly estimate the burden of the disease. METHODS: An observational, longitudinal, and comparative study was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28448524/modelling-the-vertical-distribution-of-canopy-fuel-load-using-national-forest-inventory-and-low-density-airbone-laser-scanning-data
#7
Eduardo González-Ferreiro, Stéfano Arellano-Pérez, Fernando Castedo-Dorado, Andrea Hevia, José Antonio Vega, Daniel Vega-Nieva, Juan Gabriel Álvarez-González, Ana Daría Ruiz-González
The fuel complex variables canopy bulk density and canopy base height are often used to predict crown fire initiation and spread. Direct measurement of these variables is impractical, and they are usually estimated indirectly by modelling. Recent advances in predicting crown fire behaviour require accurate estimates of the complete vertical distribution of canopy fuels. The objectives of the present study were to model the vertical profile of available canopy fuel in pine stands by using data from the Spanish national forest inventory plus low-density airborne laser scanning (ALS) metrics...
2017: PloS One
https://www.readbyqxmd.com/read/28448486/-first-mexican-consensus-of-vaccination-in-adults
#8
Luis Miguel Gutiérrez-Robledo, Elizabeth Caro-López, María de Lourdes Guerrero-Almeida, Margarita Dehesa-Violante, Eduardo Rodríguez-Noriega, Juan Miguel García-Lara, Zaira Medina-López, Renata Báez-Saldaña, Elsa Díaz-López, Flor Maria de Guadalupe Avila-Fematt, Miguel Betancourt-Cravioto, Lourdes Garcia-Garcia
For years our efforts have been focused on vaccination during childhood. Today we know that this is not enough to ensure health in the rest of the life. Childhood is as important as any other stage and, therefore, vaccination must be permanent and differentiated, according to our age, throughout life. Introducing a life course perspective in vaccination programs, with emphasis on adult vaccination, particularly in older adults, offers us the opportunity to review the performance of health programs, actions, and services in the field of immunization, as well as strengthening health promotion actions...
March 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28448411/image-quality-and-radiation-exposure-comparison-of-a-double-high-pitch-acquisition-for-coronary-computed-tomography-angiography-versus-standard-retrospective-spiral-acquisition-in-patients-with-atrial-fibrillation
#9
Carlos Eduardo Elias Dos Prazeres, Tiago Augusto Magalhães, Adriano Camargo de Castro Carneiro, Roberto Caldeira Cury, Valéria de Melo Moreira, Juliana Hiromi Silva Matsumoto Bello, Carlos Eduardo Rochitte
OBJECTIVE: The aim of this study was to compare image quality and radiation dose of coronary computed tomography (CT) angiography performed with dual-source CT scanner using 2 different protocols in patients with atrial fibrillation. METHODS: Forty-seven patients with AF underwent 2 different acquisition protocols: double high-pitch (DHP) spiral acquisition and retrospective spiral acquisition. The image quality was ranked according to a qualitative score by 2 experts: 1, no evident motion; 2, minimal motion not influencing coronary artery luminal evaluation; and 3, motion with impaired luminal evaluation...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28448316/regenerative-medicine-and-stem-cells-in-dermatology
#10
Eduardo K Moioli, Diana Bolotin, Murad Alam
BACKGROUND: Clinically relevant regenerative medicine is still in its early stages of development. Difficulties in regenerating large-scale and complex structures, the lack of safety data, and the paucity of clinical trials have slowed the process of technological advance. OBJECTIVE: To familiarize the clinician with techniques available in the laboratory and experimental approaches being tested clinically. In addition, a layout is discussed for how dermatologists can lead the way in bringing regenerative medicine to clinical reality...
April 12, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28448144/a-maldiisotopic-approach-to-discover-natural-products-cryptomaldamide-a-hybrid-tripeptide-from-the-marine-cyanobacterium-moorea-producens
#11
Robin B Kinnel, Eduardo Esquenazi, Tiago Leao, Nathan Moss, Emily Mevers, Alban R Pereira, Emily A Monroe, Anton Korobeynikov, Thomas F Murray, David Sherman, Lena Gerwick, Pieter C Dorrestein, William H Gerwick
Genome sequencing of microorganisms has revealed a greatly increased capacity for natural products biosynthesis than was previously recognized from compound isolation efforts alone. Hence, new methods are needed for the discovery and description of this hidden secondary metabolite potential. Here we show that provision of heavy nitrogen (15)N-nitrate to marine cyanobacterial cultures followed by single-filament MALDI analysis over a period of days was highly effective in identifying a new natural product with an exceptionally high nitrogen content...
April 27, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28448142/bottleneck-effect-of-n-n-dimethylformamide-in-inof-1-increasing-co2-capture-in-porous-coordination-polymers
#12
Elí Sánchez-González, Eduardo González-Zamora, Diego Martínez-Otero, Vojtech Jancik, Ilich A Ibarra
The bottleneck effect of confined N,N-dimethylformamide (DMF) molecules was observed in InOF-1 for the first time: CO2 capture was remarkably enhanced in samples of as-synthesized InOF-1, thermally activated in such a way that a small residual amount of DMF molecules remained confined within the pores (DMF@InOF-1). Dynamic CO2 adsorption experiments on DMF@InOF-1 exhibited a CO2 capture of 8.06 wt % [1.5-fold higher than that of a fully activated InOF-1 (5.24%)]. DMF@InOF-1 can reversibly adsorb/desorb 8.09% CO2 with no loss of CO2 capacity after 10 cycles, and the desorption is accomplished by only turning the CO2 flow off...
April 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28446543/comparison-of-the-natural-history-of-genital-hpv-infection-among-men-by-country-brazil-mexico-and-the-united-states
#13
Staci L Sudenga, B Nelson Torres, Roberto Silva, Luisa L Villa, Eduardo Lazcano-Ponce, Martha Abrahamsen, Maria Luiza Baggio, Jorge Salmeron, Manuel Quiterio, Anna R Giuliano
BACKGROUND: Male genital HPV prevalence and incidence has been reported to vary by geographical location. Our objective was to assess the natural history of genital HPV by country among men with a median of 48 months of follow-up. METHODS: Men aged 18-70 years were recruited from US (n=1326), Mexico (n=1349), and Brazil (n=1410). Genital specimens were collected every six months and HPV genotyping identified 37 HPV genotypes. Prevalence of HPV was compared between the three countries using the Fisher's exact test...
April 26, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28446488/eculizumab-in-a-child-with-atypical-haemolytic-uraemic-syndrome-and-haemophagocytic-lymphohistiocytosis-triggered-by-cytomegalovirus-infection
#14
Gloria M Fraga-Rodriguez, Sonia Brió-Sanagustin, Eulalia Turón-Viñas, Bradley P Dixon, Eduardo Carreras-González
We present the case of a 21-month-old girl with two rare and life-threatening conditions, atypical haemolytic uraemic syndrome (aHUS) and haemophagocytic lymphohistiocytosis (HLH), triggered by a cytomegalovirus (CMV) infection. Soon after admission, the girl became anuric and required continuous venovenous haemodiafiltration.Initial treatments included methylprednisolone, fibrinogen and plasma infusion (for HLH), plasmapheresis (for thrombotic microangiopathy), immunoglobulins (for inflammation), ganciclovir (for CMV infection) and the antibiotic cefotaxime...
April 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28446422/web-based-medical-appointment-systems-a-systematic-review
#15
Peng Zhao, Illhoi Yoo, Jaie Lavoie, Beau James Lavoie, Eduardo Simoes
BACKGROUND: Health care is changing with a new emphasis on patient-centeredness. Fundamental to this transformation is the increasing recognition of patients' role in health care delivery and design. Medical appointment scheduling, as the starting point of most non-urgent health care services, is undergoing major developments to support active involvement of patients. By using the Internet as a medium, patients are given more freedom in decision making about their preferences for the appointments and have improved access...
April 26, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28446237/oral-impacts-on-quality-of-life-and-problem-oriented-attendance-among-south-east-london-adults
#16
Piyada Gaewkhiew, Eduardo Bernabé, Jennifer E Gallagher, Charlotte Klass, Elsa K Delgado-Angulo
BACKGROUND: Dental care seeking behaviour is often driven by symptoms. The value of oral health related quality of life (OHRQoL) measures to predict utilisation of dental services is unknown. This study aims to explore the association between OHRQoL and problem-oriented dental attendance among adults. METHODS: We analysed cross-sectional data for 705 adults, aged 16 years and above, living in three boroughs of Inner South East London. Data were collected during structured interviews at home...
April 26, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28446150/signatures-of-co-evolutionary-host-pathogen-interactions-in-the-genome-of-the-entomopathogenic-nematode-steinernema-carpocapsae
#17
Mitzi Flores-Ponce, Miguel Vallebueno-Estrada, Eduardo González-Orozco, Hilda E Ramos-Aboites, J Noé García-Chávez, Nelson Simões, Rafael Montiel
BACKGROUND: The entomopathogenic nematode Steinernema carpocapsae has been used worldwide as a biocontrol agent for insect pests, making it an interesting model for understanding parasite-host interactions. Two models propose that these interactions are co-evolutionary processes in such a way that equilibrium is never reached. In one model, known as "arms race", new alleles in relevant genes are fixed in both host and pathogens by directional positive selection, producing recurrent and alternating selective sweeps...
April 26, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28446077/expression-of-mmp-13-in-human-temporomandibular-joint-disc-derangement-and-osteoarthritis
#18
Juliano Henrique Perotto, Flavio de Alcantara Camejo, Andrea Duarte Doetzer, Luis Eduardo Almeida, Marina Azevedo, Márcia Olandoski, Lucia Noronha, Paula Cristina Trevilatto
OBJECTIVE: MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular disc. This study evaluated the expression of MMP-13 in patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR), and in the presence of TMJ osteoarthrosis. METHODS: Thirty-nine human temporomandibular joint disc samples were collected and divided in two ways: ADDwR (21 samples), ADDwoR (10 samples), and a control group (8 samples); and with osteoarthrosis (10 samples) and without osteoarthrosis (29 samples)...
April 26, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28445860/brephedrone-a-new-psychoactive-substance-seized-in-brazil
#19
Yuri Machado, José Coelho Neto, Paulo Eduardo Nunes Barbosa, Rogério Araújo Lordeiro, Rosemeire Brondi Alves
At the beginning of 2015, sixty-two capsules containing red-brown crystals seized in a historical city in Brazil were sent to this forensic laboratory for drug testing analysis. The material was identified as being Brephedrone, a new psychoactive substance and a bromine synthetic cathinone that is related to serotonin transportation. This substance was analyzed by ATR-FTIR, GC-MS, LC-MS, (1)H, (13)C and 2D NMR. Brephedrone apprehensions have been previously reported in Finland, France and Spain. It was the first detection of this substance in the State of Minas Gerais...
April 15, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28445603/alternating-flow-filtration-as-an-alternative-to-internal-spin-filter-based-perfusion-process-impact-on-productivity-and-product-quality
#20
María Bosco, Cristian Paillet, Laura Mauro, Ignacio Amadeo, Eduardo Orti, Guillermina Forno
No abstract text is available yet for this article.
April 26, 2017: Biotechnology Progress
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