keyword
MENU ▼
Read by QxMD icon Read
search

NF-KB Transcriptional regulation

keyword
https://www.readbyqxmd.com/read/29776446/valproic-acid-attenuates-traumatic-spinal-cord-injury-induced-inflammation-via-stat1-and-nf-%C3%AE%C2%BAb-pathway-dependent-of-hdac3
#1
Shoubo Chen, Jingfang Ye, Xiangrong Chen, Jinnan Shi, Wenhua Wu, Wenping Lin, Weibin Lin, Yasong Li, Huangde Fu, Shun Li
BACKGROUND: Microglial polarization with M1/M2 phenotype shifts and the subsequent neuroinflammatory responses are vital contributing factors for spinal cord injury (SCI)-induced secondary injury. Nuclear factor-κB (NF-κB) is considered the central transcription factor of inflammatory mediators, which plays a crucial role in microglial activation. Lysine acetylation of STAT1 seems necessary for NF-kB pathway activity, as it is regulated by histone deacetylases (HDACs). There have been no studies that have explained if HDAC inhibition by valproic acid (VPA) affects the NF-κB pathway via acetylation of STAT1 dependent of HDAC activity in the microglia-mediated central inflammation following SCI...
May 18, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29717026/steroid-receptor-coactivator-1-interacts-with-nf-%C3%AE%C2%BAb-to-increase-the-vegfc-level-in-human-thyroid-cancer
#2
Bo Gao, Lingji Guo, Donglin Luo, Yan Jiang, Jianjie Zhao, Chengyi Mao, Yan Xu
Thyroid cancer is the most common endocrine cancer, and has a high incidence of lymphatic metastasis. Vascular endothelial growth factor C (VEGFC) is essential for development of lymphatic vessels and lymphatic metastases during carcinogenesis. Steroid receptor coactivator-1 (SRC-1) interacts with nuclear receptors and transcription factors to promote tumor proliferation and metastasis. However, the correlation between SRC-1 and VEGFC levels in the lymphatic metastases of thyroid cancer remains unclear. We analyzed 20 paired specimens of thyroid cancer tissue and normal thyroid tissue and found increased levels of SRC-1 and VEGFC proteins in 13/20 and 15/20 thyroid cancer specimens, respectively, when compared with those levels in specimens of normal thyroid tissue...
May 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29705079/gold-nanoparticles-induce-serum-amyloid-a-1-toll-like-receptor-2-mediated-nf-kb-signaling-in-lung-cells-in-vitro
#3
Cheng Teng Ng, Wai Cheong George Yip, Ee Sin Chen, Wan Yan Rebecca Poh, Boon Huat Bay, Lin Yue Lanry Yung
Gold nanoparticles (AuNPs) have emerging applications in biomedicine and the industry. Exposure to AuNPs has previously been shown to alter the transcriptional activity of nuclear factor kappa B (NF-kB), which is known to mediate physiological and pathological processes. This study seeks to provide mechanistic insights into AuNP-induced NF-kB activation in Small Airway Epithelial Cells (SAECs) in vitro. Increased NF-kB transcriptional activity (quantified by the luciferase reporter assay) was observed in AuNP-treated SAECs...
April 26, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29703138/transcriptional-profiling-of-human-bronchial-epithelial-cell-beas-2b-exposed-to-diesel-and-biomass-ultrafine-particles
#4
Andrea Grilli, Rossella Bengalli, Eleonora Longhin, Laura Capasso, Maria Carla Proverbio, Mattia Forcato, Silvio Bicciato, Maurizio Gualtieri, Cristina Battaglia, Marina Camatini
BACKGROUND: Emissions from diesel vehicles and biomass burning are the principal sources of primary ultrafine particles (UFP). The exposure to UFP has been associated to cardiovascular and pulmonary diseases, including lung cancer. Although many aspects of the toxicology of ambient particulate matter (PM) have been unraveled, the molecular mechanisms activated in human cells by the exposure to UFP are still poorly understood. Here, we present an RNA-seq time-course experiment (five time point after single dose exposure) used to investigate the differential and temporal changes induced in the gene expression of human bronchial epithelial cells (BEAS-2B) by the exposure to UFP generated from diesel and biomass combustion...
April 27, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29690521/the-gaba-a-receptor-%C3%AE-2-subunit-activates-a-neuronal-tlr4-signal-in-the-ventral-tegmental-area-that-regulates-alcohol-and-nicotine-abuse
#5
Irina Balan, Kaitlin T Warnock, Adam Puche, Marjorie C Gondre-Lewis, Harry June, Laure Aurelian
Alcoholism initiates with episodes of excessive alcohol drinking, known as binge drinking, which is one form of excessive drinking (NIAAA Newsletter, 2004) that is related to impulsivity and anxiety (Ducci et al., 2007; Edenberg et al., 2004) and is also predictive of smoking status. The predisposition of non-alcohol exposed subjects to initiate binge drinking is controlled by neuroimmune signaling that includes an innately activated neuronal Toll-like receptor 4 (TLR4) signal. This signal also regulates cognitive impulsivity, a heritable trait that defines drug abuse initiation...
April 21, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29664930/distinctive-variation-in-the-u3r-region-of-the-5-long-terminal-repeat-from-diverse-hiv-1-strains
#6
Christelle Mbondji-Wonje, Ming Dong, Xue Wang, Jiangqin Zhao, Viswanath Ragupathy, Ana M Sanchez, Thomas N Denny, Indira Hewlett
Functional mapping of the 5'LTR has shown that the U3 and the R regions (U3R) contain a cluster of regulatory elements involved in the control of HIV-1 transcription and expression. As the HIV-1 genome is characterized by extensive variability, here we aimed to describe mutations in the U3R from various HIV-1 clades and CRFs in order to highlight strain specific differences that may impact the biological properties of diverse HIV-1 strains. To achieve our purpose, the U3R sequence of plasma derived virus belonging to different clades (A1, B, C, D, F2) and recombinants (CRF02_AG, CRF01_AE and CRF22_01A1) was obtained using Illumina technology...
2018: PloS One
https://www.readbyqxmd.com/read/29594152/ionizing-radiation-induces-endothelial-inflammation-and-apoptosis-via-p90rsk-mediated-erk5-s496-phosphorylation
#7
Hang Thi Vu, Sivareddy Kotla, Kyung Ae Ko, Yuka Fujii, Yunting Tao, Jan Medina, Tamlyn Thomas, Megumi Hada, Anil K Sood, Pankaj Kumar Singh, Sarah A Milgrom, Sunil Krishnan, Keigi Fujiwara, Nhat-Tu Le, Jun-Ichi Abe
Adverse cardiovascular events are a leading nonmalignant cause of morbidity and mortality among cancer survivors who have been exposed to ionizing radiation (IR), but the exact mechanism of the cardiovascular complications induced by IR remains unclear. In this study we investigated the potential role of the p90RSK-ERK5 module in regulating IR-induced endothelial cell inflammation and apoptosis. Whole body radiation of mice with 2 Gy γ-ray significantly increased endothelial VCAM-1 expression; especially in the disturbed flow area in vivo ...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29589770/ros-and-rns-signaling-adaptive-redox-switches-through-oxidative-nitrosative-protein-modifications
#8
N T Moldogazieva, I M Mokhosoev, N B Feldman, S V Lutsenko
Over the last decade, a dual character of cell response to oxidative stress, eustress vs. distress, has become increasingly recognized. A growing body of evidence indicates that under physiological conditions, low concentrations of reactive oxygen and nitrogen species (RONS) maintained by the activity of endogenous antioxidant system (AOS) allow reversible oxidative/nitrosative modifications of key redox-sensitive residues in regulatory proteins. The reversibility of redox modifications such as Cys S-sulfenylation/S-glutathionylation/S-nitrosylation/S-persulfidation and disulfide bond formation, or Tyr nitration, which occur through electrophilic attack of RONS to nucleophilic groups in amino acid residues provides redox switches in the activities of signaling proteins...
March 28, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29589006/pretreatment-with-dihydroquercetin-a-dietary-flavonoid-protected-against-concanavalin-a-induced-immunological-hepatic-injury-in-mice-and-tnf-%C3%AE-actd-induced-apoptosis-in-hepg2-cells
#9
Jiajie Chen, Xu Sun, Tingting Xia, Qiqi Mao, Liang Zhong
We have previously demonstrated the hepatoprotective effect of dihydroquercetin (DHQ) against concanavalin A (Con A)-induced immunological hepatic injury in mice. In this study, we investigated the immunoregulatory effects of DHQ on Con A-induced liver injury in mice. DHQ administration significantly decreased the serum levels of alanine transaminase and aspartate transaminase, effectively prevented liver damage, and increased the survival rate of Con A-treated mice. Immunohistochemistry examination revealed that supplementation with DHQ obviously reduced infiltration of CD4+ and CD8+ T cells in the injured liver tissues...
March 28, 2018: Food & Function
https://www.readbyqxmd.com/read/29576747/cd38-cadpr-signaling-pathway-in-airway-disease-regulatory-mechanisms
#10
REVIEW
Deepak A Deshpande, Alonso G P Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian, Timothy F Walseth, Mathur S Kannan
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness. Inflammatory cytokines alter calcium (Ca2+ ) signaling and contractility of airway smooth muscle, which results in nonspecific airway hyperresponsiveness to agonists. In this context, Ca2+ regulatory mechanisms in airway smooth muscle and changes in these regulatory mechanisms encompass a major component of airway hyperresponsiveness...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29575726/p53-mediated-regulation-of-coactivator-associated-arginine-methyltransferase-1-carm1-expression-is-critical-for-suppression-of-adipogenesis
#11
Amit K Behera, Aditya Bhattacharya, Madavan Vasudevan, Tapas K Kundu
Coactivator associated arginine methyltransferase 1 (CARM1/PRMT4) is a type I arginine methyltransferase that mediates transcriptional activation via methylation of histone H3 on R17, R26 and R42. CARM1 is also a coactivator of transcription of various transcription factors such as NF-kB, MEF2C, β-catenin, p53, PPAR-gamma etc. CARM1 has been functionally implicated in maintenance of pluripotency, cellular differentiation and tumorigenesis; where its expression status plays an important role. Although its expression has been shown to be regulated by a few miRNAs in different contexts at post-transcriptional level, transcriptional regulation of CARM1 gene is still unexplored...
March 25, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29571741/immunobiologically-relevant-level-of-aflatoxin-b-1-alters-transcription-of-key-functional-immune-genes-phagocytosis-and-survival-of-human-dendritic-cells
#12
Jalil Mehrzad, Abbas Bahari, Mohammad Reza Bassami, Mahmoud Mahmoudi, Hesam Dehghani
The effects of naturally occurring levels of aflatoxin (AF) B1 on the expression of key molecules and function of dendritic cells (DCs) were investigated on human monocyte-derived DCs (MDDCs) by cell culture, RT-qPCR, and flow cytometry. An environmentally relevant level of AFB1 remarkably impaired the phagocytic capacity of MDDCs. Furthermore, AFB1 significantly affected the transcript levels of some key functional genes in MDDCs. It caused an up-regulation of key transcripts in cytochrome P450 (CYP) family, MyD88, NF-KB, TNF-α, TLR2, TLR4, COX-2, HLA-DR, CCR7, CD209, LFA3 and CD16...
March 20, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29562733/astragaloside-iv-prevents-obesity-associated-hypertension-by-improving-pro-inflammatory-reaction-and-leptin-resistance
#13
Ping Jiang, Dufang Ma, Xue Wang, Yongcheng Wang, Yuxin Bi, Jinlong Yang, Xuebing Wang, Xiao Li
Low-grade pro-inflammatory state and leptin resistance are important underlying mechanisms that contribute to obesityassociated hypertension. We tested the hypothesis that Astragaloside IV (As IV), known to counteract obesity and hypertension, could prevent obesity-associated hypertension by inhibiting pro-inflammatory reaction and leptin resistance. High-fat diet (HFD) induced obese rats were randomly assigned to three groups: the HFD control group (HF con group), As IV group, and the As IV + α-bungaratoxin (α-BGT) group (As IV+α-BGT group)...
March 20, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29553845/nano-gold-displayed-anti-inflammatory-property-via-nf-kb-pathways-by-suppressing-cox-2-activity
#14
Mahmood Ahmad Khan, Mohd Jahir Khan
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, affecting almost 1% of world population. Although the exact cause of RA is not known but the complex interaction between inflammatory mediators like tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2) and nitric oxide (NO) is accountable for cartilage destruction in joints. Gold is used for arthritis treatment since long without knowing its mechanism of action. Hence, the present study was designed to assess antiarthritic activity of nanogold (AuNGs) in collagen-induced arthritic (CIA) rat model by virtue of decreasing inflammatory mediators and oxidative stress...
March 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29532213/treatment-of-inflammatory-bowel-disease-via-green-tea-polyphenols-possible-application-and-protective-approaches
#15
REVIEW
Sajid Ur Rahman, Yu Li, Yingying Huang, Lei Zhu, Shibin Feng, Jinjie Wu, Xichun Wang
Inflammatory bowel disease (IBD) is a collection of inflammatory conditions of colon and small intestine which affect millions of individuals worldwide and the prevalence amount is on the rise. The organ failure as well as loss of tissue function is because of the inflammatory reaction which is the major contributor of tissue healing leading to lifelong debilitation. To stop the tough consequences of inflammation every patient pursues alternative therapy to relieve symptoms. Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-α) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2)...
April 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29502489/chitosan-oligosaccharide-promotes-osteoclast-formation-by-stimulating-the-activation-of-mapk-and-akt-signaling-pathways
#16
Bing-Li Bai, Zhong-Jie Xie, She-Ji Weng, Zong-Yi Wu, Hang Li, Zhou-Shan Tao, Viraj Boodhun, De-Yi Yan, Zi-Jian Shen, Jia-Hao Tang, Lei Yang
Chitosan Oligosaccharide (COS) has been widely used for the systemic treatment of clinical diseases such as bone tissue engineering. However, its influence on osteoclast formation, which plays a critical role in bone homeostasis, has never been investigated. The aim of this study was to investigate the effect of chitosan oligosaccharide on differentiation of osteoclast. Using cell counting kit-8, tartrate-resistant acid phosphatase staining, reverse transcription‑quantitative polymerase chain reaction assay and western blot analysis, we demonstrated that chitosan oligosaccharide cannot inhibit RANKL-induced osteoclast precursor proliferation but does promote osteoclast differentiation by stimulating the activation of p38/mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)/MAPK, extracellular signal-regulated kinase (ERK)/MAPK and protein kinase B (AKT) without affecting nuclear factor kappaB (NF-kB) signaling pathways...
July 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29479354/withaferin-a-associated-differential-regulation-of-inflammatory-cytokines
#17
Seema Dubey, Hyunho Yoon, Mark Steven Cohen, Prakash Nagarkatti, Mitzi Nagarkatti, Dev Karan
A role of inflammation-associated cytokines/chemokines has been implicated in a wide variety of human diseases. Here, we investigated the regulation of inflammatory cytokines released by monocyte-derived THP-1 cells following treatment with the dietary agent withaferin A (WFA). Membrane-based cytokine array profiling of the culture supernatant from adenosine triphosphate-stimulated WFA-treated THP-1 cells showed differential regulation of multiple cytokines/chemokines. A selected group of cytokines/chemokines [interleukin-1 beta (IL-1β), CCL2/MCP-1, granulocyte-macrophage colony stimulating factor, PDGF-AA, PTX3, cystatin-3, relaxin-2, TNFRSF8/CD30, and ACRP30] was validated at the transcription level using qPCR...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29462603/lox-1-receptor-a-potential-link-in-atherosclerosis-and-cancer
#18
REVIEW
Silvana Balzan, Valter Lubrano
Altered production of reactive oxygen species (ROS), causing lipid peroxidation and DNA damage, contributes to the progression of atherosclerosis and cancer. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a lectin-like receptor for oxidized low-density lipoproteins (ox-LDL) primarily expressed in endothelial cells and vasculature-rich organs. LOX-1 receptors is a marker for atherosclerosis, and once activated by ox-LDL or other ligands, stimulates the expression of adhesion molecules, pro-inflammatory signaling pathways and proangiogenic proteins, including NF-kB and VEGF, in vascular endothelial cells and macrophages...
April 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29452637/ubiquitin-mediated-regulation-of-ripk1-kinase-activity-independent-of-ikk-and-mk2
#19
Alessandro Annibaldi, Sidonie Wicky John, Tom Vanden Berghe, Kirby N Swatek, Jianbin Ruan, Gianmaria Liccardi, Katiuscia Bianchi, Paul R Elliott, Sze Men Choi, Samya Van Coillie, John Bertin, Hao Wu, David Komander, Peter Vandenabeele, John Silke, Pascal Meier
Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor κB (NF-κB)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains unclear whether ubiquitylation can directly repress TNF-induced death. Here, we show that ubiquitylation regulates RIPK1's cytotoxic potential not only via activation of downstream kinases and NF-kB transcriptional responses, but also by directly repressing RIPK1 kinase activity via ubiquitin-dependent inactivation...
February 15, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29428944/clusterin-reduces-cold-ischemia-reperfusion-injury-in-heart-transplantation-through-regulation-of-nf-kb-signaling-and-bax-bcl-xl-expression
#20
Guodong Liu, Hongmei Zhang, Fengyun Hao, Jing Hao, Lixiao Pan, Qing Zhao, Jinshan Wo
BACKGROUND/AIMS: Ischemia-reperfusion (I/R) injury is an unavoidable event occurring during heart transplantation and is a key factor in graft failure and the long-term survival rate of recipients. Therefore, there is an urgent need for the development of new therapies to prevent I/R injury. Clusterin is a hetero-dimeric glycoprotein with an antiapoptotic function. In this study, we investigated whether clusterin was cardioprotective in heart transplantation against I/R injury using an in vivo rat model and an in vitro cell culture system, and examined the underlying mechanisms of I/R injury...
2018: Cellular Physiology and Biochemistry
keyword
keyword
99483
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"