Xianyong Zhou, Yongming Zhu, Defei Gao, Min Li, Liang Lin, Zhanxiang Wang, Huaping Du, Yuan Xu, Jin Liu, Yang He, Yi Guo, Shuai Wang, Shigang Qiao, Yingshi Bao, Yuan Liu, Huiling Zhang
In the brain, the role of matrilin-3, an extracellular matrix component in cartilage, is unknown. Here, we identify that matrilin-3 decreased in reactive astrocytes but was unchanged in neurons after ischemic stroke in animals. Importantly, it declined in serum of patients with acute ischemic stroke. Genetic or pharmacological inhibition or supplementation of matrilin-3 aggravates or reduces brain injury, astrocytic cell death, and glial scar, respectively, but has no direct effect on neuronal cell death. RNA sequencing demonstrates that Matn3-/- mice display an increased inflammatory response profile in the ischemic brain, including the nuclear factor κB (NF-κB) signaling pathway...
March 21, 2024: Cell Reports