keyword
MENU ▼
Read by QxMD icon Read
search

p65 transcript

keyword
https://www.readbyqxmd.com/read/28918014/artificial-zinc-finger-transcription-factor-of-a20-suppresses-restenosis-in-sprague-dawley-rats-after-carotid-injury-via-the-ppar%C3%AE-pathway
#1
Zhaoyou Meng, Pan Gao, Lin Chen, Jing Peng, Jialu Huang, Min Wu, Kangning Chen, Zhenhua Zhou
The inhibition of inflammation and vascular smooth muscle cell (VSMC) proliferation is an ideal strategy to suppress intimal hyperplasia after percutaneous transluminal angioplasty (PTA). Evidence has indicated that overexpression of A20 suppresses neointima formation, but its low transfection efficiency limits its application. Hence, we upregulated A20 expression via transfection of rAd.ATF (recombinant adenovirus vector of artificial transcription factor) and rAd.A20 in rat carotid arteries after balloon dilatation (in vivo) and isolated VSMCs (in vitro)...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28917487/glutamate-attenuates-lipopolysaccharide-induced-oxidative-damage-and-mrna-expression-changes-of-tight-junction-and-defensin-proteins-inflammatory-and-apoptosis-response-signaling-molecules-in-the-intestine-of-fish
#2
Jun Jiang, Long Yin, Jin-Yang Li, Qian Li, Dan Shi, Lin Feng, Yang Liu, Wei-Dan Jiang, Pei Wu, Ye Zhao, Xiao-Qiu Zhou
The present study explored the possible preventive effects of dietary glutamate (Glu) on LPS-induced oxidative damage, mRNA expression changes of tight junction (TJ) proteins and defensins, inflammatory and apoptosis response signaling molecules in fish intestine. Young Jian carp were fed five diets supplemental graded levels of Glu (0, 4, 8, 16 and 32 g kg(-1) diet) for 63 days. The results indicated that Glu supplementation depressed LPS induced the production of reactive oxygen species (ROS) and severe oxidative damage (lipid peroxidation and protein oxidation) in fish intestine, which was partially due to the increased glutathione (GSH) content and antioxidant enzyme activities including superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR) (P < 0...
September 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28915576/hepatic-b-cell-leukemia-3-suppresses-chemically-induced-hepatocarcinogenesis-in-mice-through-altered-mapk-and-nf-%C3%AE%C2%BAb-activation
#3
Nadine Gehrke, Marcus A Wörns, Amrit Mann, Yvonne Huber, Nadine Hoevelmeyer, Thomas Longerich, Ari Waisman, Peter R Galle, Jörn M Schattenberg
The transcriptional nuclear factor kappa B (NF-κB)-coactivator B cell leukemia-3 (Bcl-3) is a molecular regulator of cell death and proliferation. Bcl-3 has been shown to be widely expressed in different cancer types including hepatocellular carcinoma (HCC). Its influence on hepatocarcinogenesis is still undetermined. To examine the role of Bcl-3 in hepatocarcinogenesis mice with hepatocyte-specific overexpression of Bcl-3 (Bcl-3(Hep)) were exposed to diethylnitrosamine (DEN) and phenobarbital (PB). Hepatic Bcl-3 overexpression attenuated DEN/PB-induced hepatocarcinogenesis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912778/neuroprotective-effects-of-annexin-a1-tripeptide-after-deep-hypothermic-circulatory-arrest-in-rats
#4
Zhiquan Zhang, Qing Ma, Bijal Shah, G Burkhard Mackensen, Donald C Lo, Joseph P Mathew, Mihai V Podgoreanu, Niccolò Terrando
Resolution agonists, including lipid mediators and peptides such as annexin A1 (ANXA1), are providing novel approaches to treat inflammatory conditions. Surgical trauma exerts a significant burden on the immune system that can affect and impair multiple organs. Perioperative cerebral injury after cardiac surgery is associated with significant adverse neurological outcomes such as delirium and postoperative cognitive dysfunction. Using a clinically relevant rat model of cardiopulmonary bypass (CPB) with deep hypothermic circulatory arrest (DHCA), we tested the pro-resolving effects of a novel bioactive ANXA1 tripeptide (ANXA1sp) on neuroinflammation and cognition...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28901418/profilin%C3%A2-1-contributes-to-cardiac-injury-induced-by-advanced-glycation-end%C3%A2-products-in-rats
#5
Dafeng Yang, Weiwei Liu, Liping Ma, Ya Wang, Jing Ma, Minna Jiang, Xu Deng, Fang Huang, Tianlun Yang, Meifang Chen
Cardiac injury, including hypertrophy and fibrosis, induced by advanced glycation end products (AGEs) has an important function in the onset and development of diabetic cardiomyopathy. Profilin‑1, a ubiquitously expressed and multifunctional actin‑binding protein, has been reported to be an important mediator in cardiac hypertrophy and fibrosis. However, whether profilin‑1 is involved in AGE‑induced cardiac hypertrophy and fibrosis remains to be determined. Therefore, the present study aimed to investigate the function of profilin‑1 in cardiac injury induced by AGEs...
September 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900044/regulation-of-autophagy-nf-%C3%AE%C2%BAb-signaling-and-cell-viability-by-mir-124-in-kras-mutant-mesenchymal-like-nsclc-cells
#6
Anita K Mehta, Kevin Hua, William Whipple, Minh-Thuy Nguyen, Ching-Ti Liu, Johannes Haybaeck, Joanne Weidhaas, Jeff Settleman, Anurag Singh
KRAS mutant non-small cell lung cancer (NSCLC) may be classified into epithelial or mesenchymal subtypes. Despite having the same "driver" mutation, mesenchymal NSCLCs are less responsive than are epithelial NSCLCs to inhibition of the RAS pathway. Identifying alternative networks that promote survival specifically in mesenchymal NSCLC may lead to more effective treatments for this subtype. Through their numerous targets in cellular signaling pathways, noncoding microRNAs (miRNAs) often function as tumor suppressors or oncogenes...
September 12, 2017: Science Signaling
https://www.readbyqxmd.com/read/28899779/eupatilin-with-ppar%C3%AE-agonistic-effects-inhibits-tnf%C3%AE-induced-mmp-signaling-in-hacat-cells
#7
Yujung Jung, Jin-Chul Kim, Yongsoo Choi, Sullim Lee, Ki Sung Kang, Yong Kee Kim, Su-Nam Kim
Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) is a flavonoid compound exhibiting several beneficial biological activities, including neuroprotection, anti-cancer, antinociception, chondroprotection, anti-oxidation, and anti-inflammation. Our previous study demonstrated that eupatilin specifically activates peroxisome proliferator-activated receptor alpha (PPARα) through direct binding. The PPAR subfamily includes ligand-dependent transcription factors that consist of three isotypes: PPARα, PPARβ/δ, and PPARγ...
September 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28889947/an-nf-%C3%AE%C2%BAb-transcription-factor-dependent-lineage-specific-transcriptional-program-promotes-regulatory-t-cell-identity-and-function
#8
Hyunju Oh, Yenkel Grinberg-Bleyer, Will Liao, Dillon Maloney, Pingzhang Wang, Zikai Wu, Jiguang Wang, Dev M Bhatt, Nicole Heise, Roland M Schmid, Matthew S Hayden, Ulf Klein, Raul Rabadan, Sankar Ghosh
Both conventional T (Tconv) cells and regulatory T (Treg) cells are activated through ligation of the T cell receptor (TCR) complex, leading to the induction of the transcription factor NF-κB. In Tconv cells, NF-κB regulates expression of genes essential for T cell activation, proliferation, and function. However the role of NF-κB in Treg function remains unclear. We conditionally deleted canonical NF-κB members p65 and c-Rel in developing and mature Treg cells and found they have unique but partially redundant roles...
September 1, 2017: Immunity
https://www.readbyqxmd.com/read/28887111/impairment-of-gill-structural-integrity-by-manganese-deficiency-or-excess-related-to-induction-of-oxidative-damage-apoptosis-and-dysfunction-of-the-physical-barrier-as-regulated-by-nf-%C3%AE%C2%BAb-caspase-and-nrf2-signaling-in-fish
#9
Wei-Dan Jiang, Ren-Jun Tang, Yang Liu, Pei Wu, Sheng-Yao Kuang, Jun Jiang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou, Lin Feng
This study is for the first time to explore the possible effects of dietary manganese (Mn) on structural integrity and the related signaling in the gills of fish. Grass carp (Ctenopharyngodon idella) were fed with six diets containing graded levels of Mn [3.65-27.86 mg Mn/kg diet] for 8 weeks. The results firstly demonstrated that Mn deficiency aggravated inflammation indicated by up-regulation of pro-inflammatory cytokines (tumour necrosis factor α, interleukin 8, and interleukin 1β mRNA levels) and down-regulation of anti-inflammatory cytokines (interleukin 10, transforming growth factor-β1) mRNA levels, which might be partially related to the up-regulation of nuclear factor kappa B (NF-κB p65) and down-regulation of nuclear inhibitor factor κBα (iκBα) mRNA levels in the gills of fish...
September 6, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28885545/trim44-is-a-poor-prognostic-factor-for-breast-cancer-patients-as-a-modulator-of-nf-%C3%AE%C2%BAb-signaling
#10
Hidetaka Kawabata, Kotaro Azuma, Kazuhiro Ikeda, Ikuko Sugitani, Keiichi Kinowaki, Takeshi Fujii, Akihiko Osaki, Toshiaki Saeki, Kuniko Horie-Inoue, Satoshi Inoue
Many of the tripartite motif (TRIM) proteins function as E3 ubiquitin ligases and are assumed to be involved in various events, including oncogenesis. In regard to tripartite motif-containing 44 (TRIM44), which is an atypical TRIM family protein lacking the RING finger domain, its pathophysiological significance in breast cancer remains unknown. We performed an immunohistochemical study of TRIM44 protein in clinical breast cancer tissues from 129 patients. The pathophysiological role of TRIM44 in breast cancer was assessed by modulating TRIM44 expression in MCF-7 and MDA-MB-231 breast cancer cells...
September 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28874447/salmonella-utilizes-zinc-to-subvert-anti-microbial-host-defense-of-macrophages-via-modulation-of-nf-%C3%AE%C2%BAb-signaling
#11
Aimin Wu, Piotr Tymoszuk, David Haschka, Simon Heeke, Stefanie Dichtl, Verena Petzer, Markus Seifert, Richard Hilbe, Sieghart Sopper, Heribert Talasz, Dirk Bumann, Cornelia Lass-Flörl, Igor Theurl, Keying Zhang, Guenter Weiss
Zinc sequestration by macrophages is considered a crucial host defense strategy against infection with the intracellular bacterium Salmonella Typhimurium. However, the underlying mechanisms remain elusive. In this study we found zinc to favor pathogen survival within macrophages. Salmonella-hosting macrophages contained higher free zinc levels than uninfected macrophages and cells that successfully eliminated bacteria, which was paralleled by impaired production of reactive oxygen (ROS) and nitrogen (RNS) species in bacteria-harboring cells...
September 5, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28865949/valproic-acid-increases-nf-%C3%AE%C2%BAb-transcriptional-activation-despite-decreasing-dna-binding-ability-in-p19-cells-which-may-play-a-role-in-vpa-initiated-teratogenesis
#12
Christina L Lamparter, Nicola A Philbrook, Louise M Winn
The nuclear factor-kappa B (NF-κB) family of transcription factors regulate gene expression in response to diverse stimuli. We previously demonstrated that valproic acid (VPA) exposure in utero decreases total cellular protein expression of the NF-κB subunit p65 in CD-1 mouse embryos with a neural tube defect but not in phenotypically normal littermates. This study evaluated p65 mRNA and protein expression in P19 cells and determined the impact on DNA binding ability and activity. Exposure to 5mM VPA decreased p65 mRNA and total cellular protein expression however, nuclear p65 protein expression was unchanged...
September 1, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28864168/liuweiwuling-tablets-attenuate-bdl-induced-hepatic-fibrosis-via-modulation-of-tgf-%C3%AE-smad-and-nf-%C3%AE%C2%BAb-signaling-pathways
#13
Huimin Liu, Fang Dong, Guangquan Li, Ming Niu, Congen Zhang, Yanzhong Han, Lanzhi He, Ping Yin, Bin Wang, Xiuxiu Sang, Ruishen Li, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: Liuweiwuling (LWWL) tablets contain a six-herb Chinese formula and are commonly prescribed to facilitate nourishment of the liver and kidneys, clear away toxic materials and activate blood circulation. Administration of LWWL is well known for its protective effects on the liver and its capacity to confer long-term stability in patients exhibiting reduced transaminase levels. Clinical studies have reported that LWWL can also be used for the treatment of liver fibrosis with associated treatment regimens resulting in a concomitant reduction in transforming growth factor β1 (TGF-β1) levels in the serum of patients with hepatic fibrosis...
August 31, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28863383/acetylenic-derivative-of-betulin-induces-apoptosis-in-endometrial-adenocarcinoma-cell-line
#14
Lukasz Szoka, Ewa Karna, Kornelia Hlebowicz-Sarat, Jacek Karaszewski, Stanisław Boryczka, Jerzy A Palka
Since betulin (Bet) and its acetylenic derivative, 28-O-propynoylbetulin (proBet) were shown to induce apoptosis in several cancer cell lines, we studied the mechanism of this process in human endometrial adenocarcinoma cells (EA). Previous studies suggested that this group of compounds affect prolidase activity (proline releasing enzyme from imidodipeptides) and collagen biosynthesis (proline utilizing process) providing substrate (proline) for proline oxidase (POX) dependent apoptosis. Here we provide evidence that Bet and proBet exhibit prolidase-inducing activity in EA cell line...
August 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28859166/primate-lentiviruses-use-at-least-three-alternative-strategies-to-suppress-nf-%C3%AE%C2%BAb-mediated-immune-activation
#15
Dominik Hotter, Teresa Krabbe, Elisabeth Reith, Ali Gawanbacht, Nadia Rahm, Ahidjo Ayouba, Benoît Van Driessche, Carine Van Lint, Martine Peeters, Frank Kirchhoff, Daniel Sauter
Primate lentiviruses have evolved sophisticated strategies to suppress the immune response of their host species. For example, HIV-2 and most simian immunodeficiency viruses (SIVs) use their accessory protein Nef to prevent T cell activation and antiviral gene expression by downmodulating the T cell receptor CD3. This Nef function was lost in HIV-1 and other vpu-encoding viruses suggesting that the acquisition of Vpu-mediated NF-κB inhibition reduced the selection pressure for inhibition of T cell activation by Nef...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28857167/tumor-necrosis-factor-alpha-inhibits-osteogenic-differentiation-of-pre-osteoblasts-by-downregulation-of-ephb4-signaling-via-activated-nuclear-factor-kappab-signaling-pathway
#16
L M Wang, N Zhao, J Zhang, Q F Sun, C Z Yang, P S Yang
BACKGROUND AND OBJECTIVE: The majority of experiments show that tumor necrosis factor-alpha (TNF-α) inhibits osteogenic differentiation of mesenchymal stem cells and pre-osteoblasts by activated nuclear factor-kappaB (NF-κB) signaling. However, the underlying mechanisms by which NF-κB signaling inhibits osteogenic differentiation are not fully understood. The aim of the present study was to investigate whether EphB4 signaling inhibition mediates the effects of TNF-α-activated NF-κB signaling on osteogenic differentiation of pre-osteoblasts...
August 31, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28851397/nf-%C3%AE%C2%BAb-regulated-microrna-574-5p-underlies-synaptic-and-cognitive-impairment-in-response-to-atmospheric-pm2-5-aspiration
#17
Tingting Ku, Ben Li, Rui Gao, Yingying Zhang, Wei Yan, Xiaotong Ji, Guangke Li, Nan Sang
BACKGROUND: PM2.5 (particulate matter ≤ 2.5 μm) is one of the leading environmental risk factors for the global burden of disease. Whereas increasing evidence has linked the adverse roles of PM2.5 with cardiovascular and respiratory diseases, limited but growing emerging evidence suggests that PM2.5 exposure can affect the nervous system, causing neuroinflammation, synaptic dysfunction and cognitive deterioration. However, the molecular mechanisms underlying the synaptic and cognitive deficits elicited by PM2...
August 29, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28842689/altered-expression-of-tumor-necrosis-factor-alpha-induced-protein-3-correlates-with-disease-severity-in-ulcerative-colitis
#18
Ishani Majumdar, Vineet Ahuja, Jaishree Paul
Ulcerative colitis (UC), an inflammatory disorder of the colon arises from dysregulated immune response towards gut microbes. Transcription factor NFκB is a major regulatory component influencing mucosal inflammation. We evaluated expression of Tumor Necrosis Factor Alpha Induced Protein3 (TNFAIP3), the inhibitor of NFκB activation and its associated partners ITCH, RNF11 and Tax1BP1 in inflamed mucosa of UC patients. We found highly significant up-regulated mRNA expression of TNFAIP3 that negatively correlated with disease activity in UC...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842466/il-18-drives-ilc3-proliferation-and-promotes-il-22-production-via-nf-%C3%AE%C2%BAb
#19
Aaron R Victor, Ansel P Nalin, Wenjuan Dong, Susan McClory, Min Wei, Charlene Mao, Raleigh D Kladney, Youssef Youssef, Wing Keung Chan, Edward L Briercheck, Tiffany Hughes, Steven D Scoville, Jason R Pitarresi, Charlie Chen, Sarah Manz, Lai-Chu Wu, Jianying Zhang, Michael C Ostrowski, Aharon G Freud, Gustavo W Leone, Michael A Caligiuri, Jianhua Yu
Group 3 innate lymphoid cells (ILC3s) are important regulators of the immune system, maintaining homeostasis in the presence of commensal bacteria, but activating immune defenses in response to microbial pathogens. ILC3s are a robust source of IL-22, a cytokine critical for stimulating the antimicrobial response. We sought to identify cytokines that can promote proliferation and induce or maintain IL-22 production by ILC3s and determine a molecular mechanism for this process. We identified IL-18 as a cytokine that cooperates with an ILC3 survival factor, IL-15, to induce proliferation of human ILC3s, as well as induce and maintain IL-22 production...
August 25, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28836948/il-8-and-ip-10-expression-from-human-bronchial-epithelial-cells-beas-2b-are-promoted-by-streptococcus-pneumoniae-endopeptidase-o-pepo
#20
Jiaqiong Zou, Long Zhou, Chunlan Hu, Peng Jing, Xiaolan Guo, Sulan Liu, Yan Lei, Shangyu Yang, Jiankang Deng, Hong Zhang
BACKGROUND: The bronchial epithelium serves as the first defendant line of host against respiratory inhaled pathogens, mainly through releasing chemokines (e.g. interleukin-8 (IL-8), interferon-induced protein 10 (IP-10) etc.) responsible for neutrophil or lymphocyte recruitment to promote the clearance of inhaled pathogens including Streptococcus pneumoniae (S. pneumoniae). Previous studies have shown that IL-8 expression is induced by pneumococcal virulence factors (e.g. pneumolysin, peptidoglycan-polysaccharides, pneumococcal surface protein A (PspA) etc...
August 24, 2017: BMC Microbiology
keyword
keyword
99482
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"