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https://www.readbyqxmd.com/read/28535417/ezrin-nf-kb-activation-regulates-epithelial-mesenchymal-transition-induced-by-egf-and-promotes-metastasis-of-colorectal-cancer
#1
Yingru Li, Zhaoyu Lin, Bin Chen, Shuang Chen, Zhipeng Jiang, Taicheng Zhou, Zehui Hou, Youyuan Wang
There is growing evidence that epithelial mesenchymal-transition (EMT) plays significant roles in terms of tumor metastasis. There are a lot of cytokines inducing EMT of tumor cells, EGF is one of the important cytokines.Ezrin is a connexin between the cytoskeleton and the cell membrane, which is closely related to the morphological movement and metastasis of tumor cells.EGF can activate Ezrin and affects cell motility. In recent years, many studies have shown that NF-kB acts as an important transcription factor, involving in the process of EMT...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28531805/troxerutin-txn-potentiated-5-fluorouracil-5-fu-treatment-of-human-gastric-cancer-through-suppressing-stat3-nf-%C3%AE%C2%BAb-and-bcl-2-signaling-pathways
#2
Gui-Yun Xu, Xiao-Jun Tang
Gastric cancer still presents a significant problem for public health worldwide. Troxerutin (TXN), a flavonoid present in tea, coffee, cereal grains, and a variety of fruits and vegetables, exhibits various pharmacological and biological activities in vitro and in vivo. We investigated the ability of TXN to reverse the in vitro and in vivo drug resistance of human gastric cancer cells, which were resistant to treatment of 5-Fluorouracil (5-FU). 5-Fu is a pyrimidine analog, which is widely used in the treatment of cancers...
May 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28525898/ginsenoside-rg3-inhibits-the-senescence-of-prostate-stromal-cells-through-down-regulation-of-interleukin-8-expression
#3
Yanfei Peng, Ran Zhang, Lingfei Kong, Yongmei Shen, Da Xu, Fang Zheng, Jianwei Liu, Qian Wu, Bona Jia, Ju Zhang
Senescent stromal cells support the development of prostate cancer and are considered potential therapeutic targets. This research evaluated the regulatory effects of ginsenoside Rg3 on the senescence of prostatic stromal cells pre-incubated in medium supplemented with 0.5% fetal bovine serum. The results revealed that ginsenoside Rg3 decreased the number of stromal cells positively stained with a senescent cell marker (senescence-associated β-galactosidase). Ginsenoside Rg3 also increased the viability of stromal cells and promoted cell cycle transition from G0/G1 to S phase, as well as inhibited the carcinoma-associated fibroblast-like phenotype in prostate stromal cells, through the up-regulation of smooth muscle cell markers SM22 and smooth muscle myosin heavy chain...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524642/polydatin-reduces-staphylococcus-aureus-lipoteichoic-acid-induced-injury-by-attenuating-reactive-oxygen-species-generation-and-tlr2-nf%C3%AE%C2%BAb-signalling
#4
Gan Zhao, Kangfeng Jiang, Haichong Wu, Changwei Qiu, Ganzhen Deng, Xiuli Peng
Staphylococcus aureus (S. aureus) causes severe inflammation in various infectious diseases, leading to high mortality. The clinical application of antibiotics has gained a significant curative effect. However, it has led to the emergence of various resistant bacteria. Therefore, in this study, we investigated the protective effect of polydatin (PD), a traditional Chinese medicine extract, on S. aureus lipoteichoic acid (LTA)-induced injury in vitro and in vivo. First, a significant improvement in the pathological conditions of PD in vivo was observed, suggesting that PD had a certain protective effect on LTA-induced injury in a mouse model...
May 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28522567/myeloid-epithelial-crosstalk-coordinates-synthesis-of-the-tissue-protective-cytokine-leukemia-inhibitory-factor-during-pneumonia
#5
Katrina E Traber, Elise M Symer, Eri Allen, Yuri Kim, Kristie L Hilliard, Gregory A Wasserman, Colin L Stewart, Matthew R Jones, Joseph P Mizgerd, Lee Joseph Quinton
In bacterial pneumonia, lung damage resulting from epithelial cell injury is a major contributor to the severity of disease, and in some cases, can lead to long-term sequelae, especially in the setting of severe lung injury or ARDS. Leukemia inhibitory factor (LIF), a member of the IL-6 cytokine family, is a critical determinant of lung tissue protection during pneumonia, but the cellular sources of LIF and the signaling pathways leading to its production in the infected lung are not known. Here, we demonstrate that lung epithelium, specifically alveolar type II cells, is the predominant site of LIF transcript induction in pneumonic mouse lungs...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28512729/protective-effects-of-nebivolol-against-interleukin-1%C3%AE-il-1%C3%AE-induced-type-ii-collagen-destruction-mediated-by-matrix-metalloproteinase-13-mmp-13
#6
Zhigang Li, Baoyi Liu, Dewei Zhao, BenJie Wang, Yupeng Liu, Yao Zhang, Fengde Tian, Borui Li
The pathological progression of osteoarthritis (OA) involves degradation of articular cartilage matrix. Type II collagen is the main component of cartilage matrix, which is degraded by pro-inflammatory cytokines such as IL-1β mediated by MMP-13. Nebivolol, a licensed drug used for the treatment of hypertension in clinics, displays its anti-inflammatory capacity in various conditions. However, whether Nebivolol has a protective effect on cartilage matrix degradation has not been reported before. In this study, we investigated the effects of Nebivolol on regulating the expression of MMP-13 and degradation of type II collagen...
May 17, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28509854/the-phenolic-fraction-of-mentha-haplocalyx-and-its-constituent-linarin-ameliorate-inflammatory-response-through-inactivation-of-nf-%C3%AE%C2%BAb-and-mapks-in-lipopolysaccharide-induced-raw264-7-cells
#7
Xiangyang Chen, Shujing Zhang, Zinan Xuan, Dongyu Ge, Xiaoming Chen, Junjie Zhang, Qian Wang, Ying Wu, Bin Liu
Mentha haplocalyx has been widely used for its flavoring and medicinal properties and as a traditional Chinese medicine with its anti-inflammation properties. The present study was designed to investigate the anti-inflammatory effects and potential molecular mechanisms of the phenolic fraction of M. haplocalyx (MHP) and its constituent linarin in lipopolysaccharide (LPS)-induced RAW264.7 cells. The high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry (HPLC-LTQ-Orbitrap MS) was used to analyze the chemical composition of MHP...
May 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28507060/alogliptin-a-dipeptidyl-peptidase-4-inhibitor-alleviates-atrial-remodeling-and-improves-mitochondrial-function-and-biogenesis-in-diabetic-rabbits
#8
Xiaowei Zhang, Zhiwei Zhang, Yungang Zhao, Ning Jiang, Jiuchun Qiu, Yajuan Yang, Jian Li, Xue Liang, Xinghua Wang, Gary Tse, Guangping Li, Tong Liu
BACKGROUND: There is increasing evidence implicating atrial mitochondrial dysfunction in the pathogenesis of atrial fibrillation. In this study, we explored whether alogliptin, a dipeptidyl peptidase-4 inhibitor, can prevent mitochondrial dysfunction and atrial remodeling in a diabetic rabbit model. METHODS AND RESULTS: A total of 90 rabbits were randomized into 3 groups as follows: control group (n=30), alloxan-induced diabetes mellitus group (n=30), and alogliptin-treated (12...
May 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28506899/hepatoprotective-activities-of-antrodia-camphorata-and-its-triterpenoid-compounds-against-ccl4-induced-liver-injury-in-mice
#9
Zi-Wei Li, Yi Kuang, Shu-Nan Tang, Kai Li, Yun Huang, Xue Qiao, Si-Wang Yu, Yew-Min Tzeng, Jen-Yu Lo, Min Ye
ETHNOPHARMACOLOGY RELEVANCE: Antrodia camphorata (AC) is a rare and precious fungus indigenous to Taiwan used as a traditional medicine for the treatment of liver injury. Triterpenoids are the major bioactive constituents of A. camphorata and have been reported to possess hepatoprotective activities. To meet the increasing demand, artificial cultivation techniques have been developed. AIM OF THE STUDY: This study aims to evaluate the hepatoprotective activities of AC samples derived from different cultivation techniques and to dissect the main active triterpenoid compounds...
May 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28504466/nepetoidin-b-a-natural-product-inhibits-lps-stimulated-nitric-oxide-production-via-modulation-of-inos-mediated-by-nf-%C3%AE%C2%BAb-mkp-5-pathways
#10
Xiaxia Wu, Hongwei Gao, Wen Sun, Jie Yu, Hao Hu, Qiongming Xu, Xiuping Chen
Previous reports showed that nepetoidin B (NTB), a natural product isolated from many herbs, has anti-fungal and anti-bacterial effects. In this study, the antiinflammatory effect of NTB was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The cytotoxic effect of NTB and LPS was determined by MTT assay. The nitric oxide (NO) production was detected by Griess assay. The TNF-α and IL-6 levels were determined by enzyme-linked immunosorbent assay kits. Protein expressions were tested by western blotting...
May 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28496416/lysophosphatidic-acid-is-associated-with-atherosclerotic-plaque-instability-by-regulating-nf-%C3%AE%C2%BAb-dependent-matrix-metalloproteinase-9-expression-via-lpa2-in-macrophages
#11
Chun Gu, Fang Wang, Zhenwen Zhao, Hongyue Wang, Xiangfeng Cong, Xi Chen
Lysophosphatidic acid (LPA), one of the simplest phospholipid signaling molecules, participates in formation and disruption of atherosclerotic plaque. Matrix metalloproteinases (MMPs) contribute to atherosclerotic plaque rupture by involving in extracellular matrix (ECM) degradation and then thinning fibrous cap. Our previous study demonstrated that macrophage-derived MMP-9 was associated with coronary plaque instability, but the relationship between LPA and MMP-9 remains unclear. The present work therefore aimed at elucidating association between LPA and MMP-9 and the regulation mechanism of LPA on MMP-9 in macrophages...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28487981/inhibition-of-notch1-protects-against-il-1%C3%AE-induced-inflammation-and-cartilage-destruction-in-temporomandibular-chondrocytes
#12
Wanggui Ying, Fang Yuan, Ping He, Ping Ji
Temporomandibular disorder (TMD) is a complex and multifactorial disease, with inflammatory response and cartilage destruction usually associated with its etiology. Notch1 is a type I transmembrane receptor, which is critical in determining the growth, differentiation and survival of various cell types. However, its role and mechanism in interleukin (IL)‑1β‑stimulated temporomandibular chondrocytes remain to be elucidated. In the present study, chondrocytes were isolated from Sprague‑Dawley rats and stimulated by IL‑1β at a concentration of 10 ng/ml, and the expression of Notch1 was inhibited by small interfering RNA...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28487955/regulation-of-mrna-gene-expression-of-members-of-the-nf-%C3%AE%C2%BAb-transcription-factor-gene-family-by-angiotensin-ii-and-relaxin-2-in-normal-and-cancer-prostate-cell-lines
#13
Kamila Domińska, Karolina Kowalska, Zuzanna Elżbieta Matysiak, Elżbieta Płuciennik, Tomasz Ochędalski, Agnieszka Wanda Piastowska-Ciesielska
An increasing number of researchers are focusing on the influence of local peptide hormones such as angiotensin II (Ang II) and relaxin 2 (RLN2) in the regulation of inflammation and carcinogenesis. The interaction between the renin‑angiotensin system (RAS) and relaxin family peptide system (RFPS) is known to influence the proliferation, adhesion and migration of normal and cancer prostate cell lines. The aim of the present study was to evaluate changes in the expression of nuclear factor‑κB subunit 1 (NFKB1), nuclear factor‑κB subunit 2 (NFKB2), REL proto‑oncogene nuclear factor‑κB p65 subunit (REL), RELA proto‑oncogene nuclear factor‑κB subunit (RELA) and RELB proto‑oncogene nuclear factor‑κB subunit (RELB) mRNA caused by Ang II and RLN2...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28487944/bortezomib-protects-against-dextran-sulfate-sodium%C3%A2-induced-ulcerative-colitis-in-mice
#14
Li-Hong Hu, Yu-Jing Fan, Qing Li, Jing-Ming Guan, Bo Qu, Feng-Hua Pei, Bing-Rong Liu
Bortezomib, a first‑in‑class proteasome inhibitor, is a standard method of treatment in multiple myeloma. In the present study, the therapeutic effect of bortezomib was evaluated in an ulcerative colitis model induced by dextran sulfate sodium (DSS) in mice, and the mechanism of action was also investigated. Mice were administered with 3% DSS drinking water for 7 consecutive days and then they were intraperitoneally treated with bortezomib (0.2, 0.6 or 1 mg/kg) for 1, 3 or 7 days. Mice in the control group and the DSS group were provided the same volume of PBS, respectively...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28487608/role-of-%C3%AE-133p53-isoform-in-nf-%C3%AE%C2%BAb-inhibitor-pdtc-mediated-growth-inhibition-of-mkn45-gastric-cancer-cells
#15
Hong-Mei Zhang, Xiao-Guang Sang, Yan-Ze Wang, Can Cui, Li Zhang, Wan-Sheng Ji
AIM: To investigate the role of Δ133p53 isoform in nuclear factor-κB (NF-κB) inhibitor pyrrolidine dithiocarbamate (PDTC)-mediated growth inhibition of MKN45 gastric cancer cells. METHODS: The growth rate of MKN45 cells after treatment with different concentrations of only PDTC or PTDC in combination with cisplatin was detected by the CCK-8 assay. mRNA expression levels of Δ133p53, p53β, and the NF-κB p65 subunit and p65 protein levels were detected by reverse transcription-polymerase chain reaction (RT-PCR) and immunofluorescence, respectively...
April 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28485511/combination-of-nexrutine-and-docetaxel-suppresses-nf%C3%AE%C2%BAb-mediated-activation-of-c-flip
#16
Yangang Zhang, Li Li, Jingyu Wang, Wei Cheng, Jiandong Zhang, Xueting Li, Zhenhua Zhang, Jingjing Gong, Rita Ghosh, Addanki Pratap Kumar, Jianping Xie
Lack of effective options following failure to conventional chemotherapeutic agent such as Docetaxel is a major clinical challenge in the management of prostate cancer. These observations underscore the need for deciphering the underlying mechanism of docetaxel resistance to enable the development of effective therapeutic approaches. We observed up regulation of the anti-apoptotic protein c-FLIP and its up stream regulators including receptor tyrosine kinase RON and transcription factor NFκB (p65) in tumors obtained from metastatic prostate cancer patients...
May 9, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28478803/peptide-11r-vivit-stimulates-osteoblastogenesis-through-regulating-the-expression-of-nuclear-factor-of-activated-t-cells-cytoplasmic-1
#17
M Li, X Wang, Z Bian, W Yao, Q He, F Tian, J Zhang, L Zhu
Osteoporosis is characterized by the imbalance of two relatively independent processes-osteoblastogenesis and osteoclastogenesis. Calcineurin (Cn)/nuclear factor of activated T cells (NFAT)(Cn/NFAT) signaling pathway is involved in these two processes in bone metabolism, but its potential as a target to treat osteoporosis needs to be defined. The aim of this study is to investigate the inhibition of polypeptide 11R-VIVIT onCn/NFAT signaling pathway. Rat calvaria (RC) cells were prepared from experimental model of osteoporosis in rat...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28474156/jnk-inhibitor-sp600125-attenuates-paraquat-induced-acute-lung-injury-an-in-vivo-and-in-vitro-study
#18
Haitao Shen, Na Wu, Yu Wang, Xinfei Han, Qiang Zheng, Xue Cai, Honglei Zhang, Min Zhao
Acute lung injury (ALI) is a major complication soon after paraquat poisoning and rapidly progresses with high mortality. However, the specific mechanism underlying paraquat-induced ALI is still unclear. In this study, the mechanism underlying the protective effects of SP600125 on paraquat-induced ALI was investigated according to oxidative stress, inflammation, and apoptosis. The rats were randomly assigned into the control group (CON), the paraquat poisoning group (PQ), and the PQ + SP600125 group (SP). A549 cells were divided into the Con group, Pq group, and Sp group...
May 4, 2017: Inflammation
https://www.readbyqxmd.com/read/28473882/sirtuin-1-regulates-matrix-metalloproteinase-13-expression-induced-by-porphyromonas-endodontalis-lipopolysaccharide-via-targeting-nuclear-factor-%C3%AE%C2%BAb-in-osteoblasts
#19
Liu Qu, Yaqiong Yu, Lihong Qiu, Di Yang, Lu Yan, Jiajie Guo, Rabita Jahan
Porphyromonas endodontalis lipopolysaccharide (P.e LPS) is an important initiating factor for periapical inflammation and bone destruction. Matrix metalloproteinase-13 (MMP-13) has been shown to participate in the formation and diffusion of periapical bone lesion in chronic apical periodontitis. Sirtuin 1 (SIRT1) is a key regulator of inflammation in mammalian cells which suppresses the release of inflammatory mediators. This study aimed to explore the role of SIRT1 in regulating MMP-13 expression induced by P...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28469251/lipopolysaccharide-induced-nf-%C3%AE%C2%BAb-nuclear-translocation-is-primarily-dependent-on-myd88-but-tnf%C3%AE-expression-requires-trif-and-myd88
#20
Jiro Sakai, Eugenia Cammarota, John A Wright, Pietro Cicuta, Rachel A Gottschalk, Ning Li, Iain D C Fraser, Clare E Bryant
TLR4 signalling through the MyD88 and TRIF-dependent pathways initiates translocation of the transcription factor NF-κB into the nucleus. In cell population studies using mathematical modeling and functional analyses, Cheng et al. suggested that LPS-driven activation of MyD88, in the absence of TRIF, impairs NF-κB translocation. We tested the model proposed by Cheng et al. using real-time single cell analysis in macrophages expressing EGFP-tagged p65 and a TNFα promoter-driven mCherry. Following LPS stimulation, cells lacking TRIF show a pattern of NF-κB dynamics that is unaltered from wild-type cells, but activation of the TNFα promoter is impaired...
May 3, 2017: Scientific Reports
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