keyword
https://read.qxmd.com/read/38558438/what-is-slough-defining-the-proteomic-and-microbial-composition-of-slough-and-its-implications-for-wound-healing
#1
JOURNAL ARTICLE
Elizabeth C Townsend, J Z Alex Cheong, Michael Radzietza, Blaine Fritz, Matthew Malone, Thomas Bjarnsholt, Karen Ousey, Terry Swanson, Gregory Schultz, Angela L F Gibson, Lindsay R Kalan
Slough is a well-known feature of non-healing wounds. This pilot study aims to determine the proteomic and microbiologic components of slough as well as interrogate the associations between wound slough components and wound healing. Ten subjects with slow-to-heal wounds and visible slough were enrolled. Aetiologies included venous stasis ulcers, post-surgical site infections and pressure ulcers. Patient co-morbidities and wound healing outcome at 3-months post-sample collection was recorded. Debrided slough was analysed microscopically, through untargeted proteomics, and high-throughput bacterial 16S-ribosomal gene sequencing...
April 1, 2024: Wound Repair and Regeneration
https://read.qxmd.com/read/38539013/long-term-in-vivo-three-photon-imaging-reveals-region-specific-differences-in-healthy-and-regenerative-oligodendrogenesis
#2
JOURNAL ARTICLE
Michael A Thornton, Gregory L Futia, Michael E Stockton, Samuel A Budoff, Alexandra N Ramirez, Baris Ozbay, Omer Tzang, Karl Kilborn, Alon Poleg-Polsky, Diego Restrepo, Emily A Gibson, Ethan G Hughes
The generation of new myelin-forming oligodendrocytes in the adult central nervous system is critical for cognitive function and regeneration following injury. Oligodendrogenesis varies between gray and white matter regions, suggesting that local cues drive regional differences in myelination and the capacity for regeneration. However, the layer- and region-specific regulation of oligodendrocyte populations is unclear due to the inability to monitor deep brain structures in vivo. Here we harnessed the superior imaging depth of three-photon microscopy to permit long-term, longitudinal in vivo three-photon imaging of the entire cortical column and subcortical white matter in adult mice...
March 27, 2024: Nature Neuroscience
https://read.qxmd.com/read/38460547/impact-of-risk-based-therapy-on-late-morbidity-and-mortality-in-neuroblastoma-survivors-a-report-from-the-childhood-cancer-survivor-study
#3
JOURNAL ARTICLE
Danielle Novetsky Friedman, Pamela J Goodman, Wendy M Leisenring, Lisa R Diller, Susan L Cohn, Rebecca M Howell, Susan A Smith, Emily S Tonorezos, Suzanne L Wolden, Joseph P Neglia, Kirsten K Ness, Todd M Gibson, Paul C Nathan, Lucie M Turcotte, Brent R Weil, Leslie L Robison, Kevin C Oeffinger, Gregory T Armstrong, Charles A Sklar, Tara O Henderson
BACKGROUND: Early efforts at risk-adapted therapy for neuroblastoma are predicted to result in differential late effects; the magnitude of these differences have not been well-described. METHODS: Late mortality, subsequent malignant neoplasms (SMN), and severe/life-threatening chronic health conditions (CHCs), graded according to CTCAE v4.03, were assessed among 5-year CCSS survivors of neuroblastoma diagnosed 1987-1999. Using age, stage at diagnosis, and treatment, survivors were classified into risk groups (low [n = 425]; intermediate [n = 252]; high [n = 245])...
March 9, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38454124/polygenic-risk-scores-radiation-treatment-exposures-and-subsequent-cancer-risk-in-childhood-cancer-survivors
#4
JOURNAL ARTICLE
Todd M Gibson, Danielle M Karyadi, Stephen W Hartley, Michael A Arnold, Amy Berrington de Gonzalez, Miriam R Conces, Rebecca M Howell, Vidushi Kapoor, Wendy M Leisenring, Joseph P Neglia, Joshua N Sampson, Lucie M Turcotte, Stephen J Chanock, Gregory T Armstrong, Lindsay M Morton
Survivors of childhood cancer are at increased risk for subsequent cancers attributable to the late effects of radiotherapy and other treatment exposures; thus, further understanding of the impact of genetic predisposition on risk is needed. Combining genotype data for 11,220 5-year survivors from the Childhood Cancer Survivor Study and the St Jude Lifetime Cohort, we found that cancer-specific polygenic risk scores (PRSs) derived from general population, genome-wide association study, cancer loci identified survivors of European ancestry at increased risk of subsequent basal cell carcinoma (odds ratio per s...
March 7, 2024: Nature Medicine
https://read.qxmd.com/read/38394591/achievement-of-target-gain-larger-than-unity-in-an-inertial-fusion-experiment
#5
JOURNAL ARTICLE
H Abu-Shawareb, R Acree, P Adams, J Adams, B Addis, R Aden, P Adrian, B B Afeyan, M Aggleton, L Aghaian, A Aguirre, D Aikens, J Akre, F Albert, M Albrecht, B J Albright, J Albritton, J Alcala, C Alday, D A Alessi, N Alexander, J Alfonso, N Alfonso, E Alger, S J Ali, Z A Ali, A Allen, W E Alley, P Amala, P A Amendt, P Amick, S Ammula, C Amorin, D J Ampleford, R W Anderson, T Anklam, N Antipa, B Appelbe, C Aracne-Ruddle, E Araya, T N Archuleta, M Arend, P Arnold, T Arnold, A Arsenlis, J Asay, L J Atherton, D Atkinson, R Atkinson, J M Auerbach, B Austin, L Auyang, A A S Awwal, N Aybar, J Ayers, S Ayers, T Ayers, S Azevedo, B Bachmann, C A Back, J Bae, D S Bailey, J Bailey, T Baisden, K L Baker, H Baldis, D Barber, M Barberis, D Barker, A Barnes, C W Barnes, M A Barrios, C Barty, I Bass, S H Batha, S H Baxamusa, G Bazan, J K Beagle, R Beale, B R Beck, J B Beck, M Bedzyk, R G Beeler, R G Beeler, W Behrendt, L Belk, P Bell, M Belyaev, J F Benage, G Bennett, L R Benedetti, L X Benedict, R L Berger, T Bernat, L A Bernstein, B Berry, L Bertolini, G Besenbruch, J Betcher, R Bettenhausen, R Betti, B Bezzerides, S D Bhandarkar, R Bickel, J Biener, T Biesiada, K Bigelow, J Bigelow-Granillo, V Bigman, R M Bionta, N W Birge, M Bitter, A C Black, R Bleile, D L Bleuel, E Bliss, E Bliss, B Blue, T Boehly, K Boehm, C D Boley, R Bonanno, E J Bond, T Bond, M J Bonino, M Borden, J-L Bourgade, J Bousquet, J Bowers, M Bowers, R Boyd, D Boyle, A Bozek, D K Bradley, K S Bradley, P A Bradley, L Bradley, L Brannon, P S Brantley, D Braun, T Braun, K Brienza-Larsen, R Briggs, T M Briggs, J Britten, E D Brooks, D Browning, M W Bruhn, T A Brunner, H Bruns, G Brunton, B Bryant, T Buczek, J Bude, L Buitano, S Burkhart, J Burmark, A Burnham, R Burr, L E Busby, B Butlin, R Cabeltis, M Cable, W H Cabot, B Cagadas, J Caggiano, R Cahayag, S E Caldwell, S Calkins, D A Callahan, J Calleja-Aguirre, L Camara, D Camp, E M Campbell, J H Campbell, B Carey, R Carey, K Carlisle, L Carlson, L Carman, J Carmichael, A Carpenter, C Carr, J A Carrera, D Casavant, A Casey, D T Casey, A Castillo, E Castillo, J I Castor, C Castro, W Caughey, R Cavitt, J Celeste, P M Celliers, C Cerjan, G Chandler, B Chang, C Chang, J Chang, L Chang, R Chapman, T D Chapman, L Chase, H Chen, H Chen, K Chen, L-Y Chen, B Cheng, J Chittenden, C Choate, J Chou, R E Chrien, M Chrisp, K Christensen, M Christensen, N S Christiansen, A R Christopherson, M Chung, J A Church, A Clark, D S Clark, K Clark, R Clark, L Claus, B Cline, J A Cline, J A Cobble, K Cochrane, B Cohen, S Cohen, M R Collette, G W Collins, L A Collins, T J B Collins, A Conder, B Conrad, M Conyers, A W Cook, D Cook, R Cook, J C Cooley, G Cooper, T Cope, S R Copeland, F Coppari, J Cortez, J Cox, D H Crandall, J Crane, R S Craxton, M Cray, A Crilly, J W Crippen, D Cross, M Cuneo, G Cuotts, C E Czajka, D Czechowicz, T Daly, P Danforth, C Danly, R Darbee, B Darlington, P Datte, L Dauffy, G Davalos, S Davidovits, P Davis, J Davis, S Dawson, R D Day, T H Day, M Dayton, C Deck, C Decker, C Deeney, K A DeFriend, G Deis, N D Delamater, J A Delettrez, R Demaret, S Demos, S M Dempsey, R Desjardin, T Desjardins, M P Desjarlais, E L Dewald, J DeYoreo, S Diaz, G Dimonte, T R Dittrich, L Divol, S N Dixit, J Dixon, A Do, E S Dodd, D Dolan, A Donovan, M Donovan, T Döppner, C Dorrer, N Dorsano, M R Douglas, D Dow, J Downie, E Downing, M Dozieres, V Draggoo, D Drake, R P Drake, T Drake, G Dreifuerst, O Drury, D F DuBois, P F DuBois, G Dunham, M Durocher, R Dylla-Spears, A K L Dymoke-Bradshaw, B Dzenitis, C Ebbers, M Eckart, S Eddinger, D Eder, D Edgell, M J Edwards, P Efthimion, J H Eggert, B Ehrlich, P Ehrmann, S Elhadj, C Ellerbee, N S Elliott, C L Ellison, F Elsner, M Emerich, K Engelhorn, T England, E English, P Epperson, R Epstein, G Erbert, M A Erickson, D J Erskine, A Erlandson, R J Espinosa, C Estes, K G Estabrook, S Evans, A Fabyan, J Fair, R Fallejo, N Farmer, W A Farmer, M Farrell, V E Fatherley, M Fedorov, E Feigenbaum, T Fehrenbach, M Feit, B Felker, W Ferguson, J C Fernandez, A Fernandez-Panella, S Fess, J E Field, C V Filip, J R Fincke, T Finn, S M Finnegan, R G Finucane, M Fischer, A Fisher, J Fisher, B Fishler, D Fittinghoff, P Fitzsimmons, M Flegel, K A Flippo, J Florio, J Folta, P Folta, L R Foreman, C Forrest, A Forsman, J Fooks, M Foord, R Fortner, K Fournier, D E Fratanduono, N Frazier, T Frazier, C Frederick, M S Freeman, J Frenje, D Frey, G Frieders, S Friedrich, D H Froula, J Fry, T Fuller, J Gaffney, S Gales, B Le Galloudec, K K Le Galloudec, A Gambhir, L Gao, W J Garbett, A Garcia, C Gates, E Gaut, P Gauthier, Z Gavin, J Gaylord, C G R Geddes, M Geissel, F Génin, J Georgeson, H Geppert-Kleinrath, V Geppert-Kleinrath, N Gharibyan, J Gibson, C Gibson, E Giraldez, V Glebov, S G Glendinning, S Glenn, S H Glenzer, S Goade, P L Gobby, S R Goldman, B Golick, M Gomez, V Goncharov, D Goodin, P Grabowski, E Grafil, P Graham, J Grandy, E Grasz, F R Graziani, G Greenman, J A Greenough, A Greenwood, G Gregori, T Green, J R Griego, G P Grim, J Grondalski, S Gross, J Guckian, N Guler, B Gunney, G Guss, S Haan, J Hackbarth, L Hackel, R Hackel, C Haefner, C Hagmann, K D Hahn, S Hahn, B J Haid, B M Haines, B M Hall, C Hall, G N Hall, M Hamamoto, S Hamel, C E Hamilton, B A Hammel, J H Hammer, G Hampton, A Hamza, A Handler, S Hansen, D Hanson, R Haque, D Harding, E Harding, J D Hares, D B Harris, J A Harte, E P Hartouni, R Hatarik, S Hatchett, A A Hauer, M Havre, R Hawley, J Hayes, J Hayes, S Hayes, A Hayes-Sterbenz, C A Haynam, D A Haynes, D Headley, A Heal, J E Heebner, S Heerey, G M Heestand, R Heeter, N Hein, C Heinbockel, C Hendricks, M Henesian, J Heninger, J Henrikson, E A Henry, E B Herbold, M R Hermann, G Hermes, J E Hernandez, V J Hernandez, M C Herrmann, H W Herrmann, O D Herrera, D Hewett, R Hibbard, D G Hicks, D P Higginson, D Hill, K Hill, T Hilsabeck, D E Hinkel, D D Ho, V K Ho, J K Hoffer, N M Hoffman, M Hohenberger, M Hohensee, W Hoke, D Holdener, F Holdener, J P Holder, B Holko, D Holunga, J F Holzrichter, J Honig, D Hoover, D Hopkins, L F Berzak Hopkins, M Hoppe, M L Hoppe, J Horner, R Hornung, C J Horsfield, J Horvath, D Hotaling, R House, L Howell, W W Hsing, S X Hu, H Huang, J Huckins, H Hui, K D Humbird, J Hund, J Hunt, O A Hurricane, M Hutton, K H-K Huynh, L Inandan, C Iglesias, I V Igumenshchev, I Ivanovich, N Izumi, M Jackson, J Jackson, S D Jacobs, G James, K Jancaitis, J Jarboe, L C Jarrott, D Jasion, J Jaquez, J Jeet, A E Jenei, J Jensen, J Jimenez, R Jimenez, D Jobe, Z Johal, H M Johns, D Johnson, M A Johnson, M Gatu Johnson, R J Johnson, S Johnson, S A Johnson, T Johnson, K Jones, O Jones, M Jones, R Jorge, H J Jorgenson, M Julian, B I Jun, R Jungquist, J Kaae, N Kabadi, D Kaczala, D Kalantar, K Kangas, V V Karasiev, M Karasik, V Karpenko, A Kasarky, K Kasper, R Kauffman, M I Kaufman, C Keane, L Keaty, L Kegelmeyer, P A Keiter, P A Kellett, J Kellogg, J H Kelly, S Kemic, A J Kemp, G E Kemp, G D Kerbel, D Kershaw, S M Kerr, T J Kessler, M H Key, S F Khan, H Khater, C Kiikka, J Kilkenny, Y Kim, Y-J Kim, J Kimko, M Kimmel, J M Kindel, J King, R K Kirkwood, L Klaus, D Klem, J L Kline, J Klingmann, G Kluth, P Knapp, J Knauer, J Knipping, M Knudson, D Kobs, J Koch, T Kohut, C Kong, J M Koning, P Koning, S Konior, H Kornblum, L B Kot, B Kozioziemski, M Kozlowski, P M Kozlowski, J Krammen, N S Krasheninnikova, C M Krauland, B Kraus, W Krauser, J D Kress, A L Kritcher, E Krieger, J J Kroll, W L Kruer, M K G Kruse, S Kucheyev, M Kumbera, S Kumpan, J Kunimune, E Kur, B Kustowski, T J T Kwan, G A Kyrala, S Laffite, M Lafon, K LaFortune, L Lagin, B Lahmann, B Lairson, O L Landen, T Land, M Lane, D Laney, A B Langdon, J Langenbrunner, S H Langer, A Langro, N E Lanier, T E Lanier, D Larson, B F Lasinski, D Lassle, D LaTray, G Lau, N Lau, C Laumann, A Laurence, T A Laurence, J Lawson, H P Le, R R Leach, L Leal, A Leatherland, K LeChien, B Lechleiter, A Lee, M Lee, T Lee, R J Leeper, E Lefebvre, J-P Leidinger, B LeMire, R W Lemke, N C Lemos, S Le Pape, R Lerche, S Lerner, S Letts, K Levedahl, T Lewis, C K Li, H Li, J Li, W Liao, Z M Liao, D Liedahl, J Liebman, G Lindford, E L Lindman, J D Lindl, H Loey, R A London, F Long, E N Loomis, F E Lopez, H Lopez, E Losbanos, S Loucks, R Lowe-Webb, E Lundgren, A P Ludwigsen, R Luo, J Lusk, R Lyons, T Ma, Y Macallop, M J MacDonald, B J MacGowan, J M Mack, A J Mackinnon, S A MacLaren, A G MacPhee, G R Magelssen, J Magoon, R M Malone, T Malsbury, R Managan, R Mancini, K Manes, D Maney, D Manha, O M Mannion, A M Manuel, M J-E Manuel, E Mapoles, G Mara, T Marcotte, E Marin, M M Marinak, D A Mariscal, E F Mariscal, E V Marley, J A Marozas, R Marquez, C D Marshall, F J Marshall, M Marshall, S Marshall, J Marticorena, J I Martinez, D Martinez, I Maslennikov, D Mason, R J Mason, L Masse, W Massey, P-E Masson-Laborde, N D Masters, D Mathisen, E Mathison, J Matone, M J Matthews, C Mattoon, T R Mattsson, K Matzen, C W Mauche, M Mauldin, T McAbee, M McBurney, T Mccarville, R L McCrory, A M McEvoy, C McGuffey, M Mcinnis, P McKenty, M S McKinley, J B McLeod, A McPherson, B Mcquillan, M Meamber, K D Meaney, N B Meezan, R Meissner, T A Mehlhorn, N C Mehta, J Menapace, F E Merrill, B T Merritt, E C Merritt, D D Meyerhofer, S Mezyk, R J Mich, P A Michel, D Milam, C Miller, D Miller, D S Miller, E Miller, E K Miller, J Miller, M Miller, P E Miller, T Miller, W Miller, V Miller-Kamm, M Millot, J L Milovich, P Minner, J-L Miquel, S Mitchell, K Molvig, R C Montesanti, D S Montgomery, M Monticelli, A Montoya, J D Moody, A S Moore, E Moore, M Moran, J C Moreno, K Moreno, B E Morgan, T Morrow, J W Morton, E Moses, K Moy, R Muir, M S Murillo, J E Murray, J R Murray, D H Munro, T J Murphy, F M Munteanu, J Nafziger, T Nagayama, S R Nagel, R Nast, R A Negres, A Nelson, D Nelson, J Nelson, S Nelson, S Nemethy, P Neumayer, K Newman, M Newton, H Nguyen, J-M G Di Nicola, P Di Nicola, C Niemann, A Nikroo, P M Nilson, A Nobile, V Noorai, R C Nora, M Norton, M Nostrand, V Note, S Novell, P F Nowak, A Nunez, R A Nyholm, M O'Brien, A Oceguera, J A Oertel, A L Oesterle, J Okui, B Olejniczak, J Oliveira, P Olsen, B Olson, K Olson, R E Olson, Y P Opachich, N Orsi, C D Orth, M Owen, S Padalino, E Padilla, R Paguio, S Paguio, J Paisner, S Pajoom, A Pak, S Palaniyappan, K Palma, T Pannell, F Papp, D Paras, T Parham, H-S Park, A Pasternak, S Patankar, M V Patel, P K Patel, R Patterson, S Patterson, B Paul, M Paul, E Pauli, O T Pearce, J Pearcy, A Pedretti, B Pedrotti, A Peer, L J Pelz, B Penetrante, J Penner, A Perez, L J Perkins, E Pernice, T S Perry, S Person, D Petersen, T Petersen, D L Peterson, E B Peterson, J E Peterson, J L Peterson, K Peterson, R R Peterson, R D Petrasso, F Philippe, D Phillion, T J Phipps, E Piceno, L Pickworth, Y Ping, J Pino, K Piston, R Plummer, G D Pollack, S M Pollaine, B B Pollock, D Ponce, J Ponce, J Pontelandolfo, J L Porter, J Post, O Poujade, C Powell, H Powell, G Power, M Pozulp, M Prantil, M Prasad, S Pratuch, S Price, K Primdahl, S Prisbrey, R Procassini, A Pruyne, B Pudliner, S R Qiu, K Quan, M Quinn, J Quintenz, P B Radha, F Rainer, J E Ralph, K S Raman, R Raman, P W Rambo, S Rana, A Randewich, D Rardin, M Ratledge, N Ravelo, F Ravizza, M Rayce, A Raymond, B Raymond, B Reed, C Reed, S Regan, B Reichelt, V Reis, S Reisdorf, V Rekow, B A Remington, A Rendon, W Requieron, M Rever, H Reynolds, J Reynolds, J Rhodes, M Rhodes, M C Richardson, B Rice, N G Rice, R Rieben, A Rigatti, S Riggs, H G Rinderknecht, K Ring, B Riordan, R Riquier, C Rivers, D Roberts, V Roberts, G Robertson, H F Robey, J Robles, P Rocha, G Rochau, J Rodriguez, S Rodriguez, M D Rosen, M Rosenberg, G Ross, J S Ross, P Ross, J Rouse, D Rovang, A M Rubenchik, M S Rubery, C L Ruiz, M Rushford, B Russ, J R Rygg, B S Ryujin, R A Sacks, R F Sacks, K Saito, T Salmon, J D Salmonson, J Sanchez, S Samuelson, M Sanchez, C Sangster, A Saroyan, J Sater, A Satsangi, S Sauers, R Saunders, J P Sauppe, R Sawicki, D Sayre, M Scanlan, K Schaffers, G T Schappert, S Schiaffino, D J Schlossberg, D W Schmidt, P F Schmit, J M Smidt, D H G Schneider, M B Schneider, R Schneider, M Schoff, M Schollmeier, C R Schroeder, S E Schrauth, H A Scott, I Scott, J M Scott, R H H Scott, C R Scullard, T Sedillo, F H Seguin, W Seka, J Senecal, S M Sepke, L Seppala, K Sequoia, J Severyn, J M Sevier, N Sewell, S Seznec, R C Shah, J Shamlian, D Shaughnessy, M Shaw, R Shaw, C Shearer, R Shelton, N Shen, M W Sherlock, A I Shestakov, E L Shi, S J Shin, N Shingleton, W Shmayda, M Shor, M Shoup, C Shuldberg, L Siegel, F J Silva, A N Simakov, B T Sims, D Sinars, P Singh, H Sio, K Skulina, S Skupsky, S Slutz, M Sluyter, V A Smalyuk, D Smauley, R M Smeltser, C Smith, I Smith, J Smith, L Smith, R Smith, R Smith, M Schölmerich, R Sohn, S Sommer, C Sorce, M Sorem, J M Soures, M L Spaeth, B K Spears, S Speas, D Speck, R Speck, J Spears, T Spinka, P T Springer, M Stadermann, B Stahl, J Stahoviak, J Stanley, L G Stanton, R Steele, W Steele, D Steinman, R Stemke, R Stephens, S Sterbenz, P Sterne, D Stevens, J Stevers, C H Still, C Stoeckl, W Stoeffl, J S Stolken, C Stolz, E Storm, G Stone, S Stoupin, E Stout, I Stowers, R Strauser, H Streckart, J Streit, D J Strozzi, J Stutz, L Summers, T Suratwala, G Sutcliffe, L J Suter, S B Sutton, V Svidzinski, G Swadling, W Sweet, A Szoke, M Tabak, M Takagi, A Tambazidis, V Tang, M Taranowski, L A Taylor, S Telford, W Theobald, M Thi, A Thomas, C A Thomas, I Thomas, R Thomas, I J Thompson, A Thongstisubskul, C B Thorsness, G Tietbohl, R E Tipton, M Tobin, N Tomlin, R Tommasini, A J Toreja, J Torres, R P J Town, S Townsend, J Trenholme, A Trivelpiece, C Trosseille, H Truax, D Trummer, S Trummer, T Truong, D Tubbs, E R Tubman, T Tunnell, D Turnbull, R E Turner, M Ulitsky, R Upadhye, J L Vaher, P VanArsdall, D VanBlarcom, M Vandenboomgaerde, R VanQuinlan, B M Van Wonterghem, W S Varnum, A L Velikovich, A Vella, C P Verdon, B Vermillion, S Vernon, R Vesey, J Vickers, R M Vignes, M Visosky, J Vocke, P L Volegov, S Vonhof, R Von Rotz, H X Vu, M Vu, D Wall, J Wall, R Wallace, B Wallin, D Walmer, C A Walsh, C F Walters, C Waltz, A Wan, A Wang, Y Wang, J S Wark, B E Warner, J Watson, R G Watt, P Watts, J Weaver, R P Weaver, S Weaver, C R Weber, P Weber, S V Weber, P Wegner, B Welday, L Welser-Sherrill, K Weiss, K B Wharton, G F Wheeler, W Whistler, R K White, H D Whitley, P Whitman, M E Wickett, K Widmann, C Widmayer, J Wiedwald, R Wilcox, S Wilcox, C Wild, B H Wilde, C H Wilde, K Wilhelmsen, M D Wilke, H Wilkens, P Wilkins, S C Wilks, E A Williams, G J Williams, W Williams, W H Williams, D C Wilson, B Wilson, E Wilson, R Wilson, S Winters, P J Wisoff, M Wittman, J Wolfe, A Wong, K W Wong, L Wong, N Wong, R Wood, D Woodhouse, J Woodruff, D T Woods, S Woods, B N Woodworth, E Wooten, A Wootton, K Work, J B Workman, J Wright, M Wu, C Wuest, F J Wysocki, H Xu, M Yamaguchi, B Yang, S T Yang, J Yatabe, C B Yeamans, B C Yee, S A Yi, L Yin, B Young, C S Young, C V Young, P Young, K Youngblood, J Yu, R Zacharias, G Zagaris, N Zaitseva, F Zaka, F Ze, B Zeiger, M Zika, G B Zimmerman, T Zobrist, J D Zuegel, A B Zylstra
On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys...
February 9, 2024: Physical Review Letters
https://read.qxmd.com/read/38380940/regional-practice-variation-and-outcomes-in-the-standard-versus-accelerated-initiation-of-renal-replacement-therapy-in-acute-kidney-injury-starrt-aki-trial-a-post-hoc-secondary-analysis
#6
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
https://read.qxmd.com/read/38325376/sequential-activity-of-ca1-hippocampal-cells-constitutes-a-temporal-memory-map-for-associative-learning-in-mice
#7
JOURNAL ARTICLE
Ming Ma, Fabio Simoes de Souza, Gregory L Futia, Sean R Anderson, Jose Riguero, Daniel Tollin, Arianna Gentile-Polese, Jonathan P Platt, Kira Steinke, Naoki Hiratani, Emily A Gibson, Diego Restrepo
Sequential neural dynamics encoded by time cells play a crucial role in hippocampal function. However, the role of hippocampal sequential neural dynamics in associative learning is an open question. We used two-photon Ca2+ imaging of dorsal CA1 (dCA1) neurons in the stratum pyramidale (SP) in head-fixed mice performing a go-no go associative learning task to investigate how odor valence is temporally encoded in this area of the brain. We found that SP cells responded differentially to the rewarded or unrewarded odor...
February 1, 2024: Current Biology: CB
https://read.qxmd.com/read/38305113/intestinal-barrier-biomarkers-in-clinical-evaluation-of-patients-with-inflammatory-bowel-disease
#8
JOURNAL ARTICLE
Tamara Mogilevski, Anke L Nguyen, Mary Ajamian, Rebecca Smith, Sam Rosella, Miles P Sparrow, Gregory T Moore, Peter R Gibson
BACKGROUND: Inflammatory bowel disease (IBD) is associated with chronic intestinal barrier dysfunction, though its non-invasive assessment remains challenging. This study aimed to determine how four putative circulating markers vary across differing states of intestinal inflammation and with therapy in patients with IBD. METHODS: Plasma samples from one prospective cross-sectional and four longitudinal studies, including healthy controls, were analysed for markers of lipopolysaccharide translocation, lipopolysaccharide-binding protein (LBP) and soluble-CD14 (sCD14), and markers of epithelial injury, syndecan-1 and intestinal-type fatty acid-binding protein (IFABP)...
March 1, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38300573/the-protective-roles-of-coping-self-efficacy-and-social-support-for-posttraumatic-stress-during-the-covid-19-pandemic
#9
JOURNAL ARTICLE
Christina X Korth, Gregory C Gibson, Anthony Vander Horst, Kimberly Cleveland, Joel W Hughes
OBJECTIVE: This study examined the roles of social support and coping self-efficacy (CSE) in attenuating posttraumatic stress (PTS) symptoms during the COVID-19 pandemic among a nonclinical university student sample. METHOD: Participants ( n = 610; 59% female) completed questionaries assessing psychological distress (Kessler Psychological Distress Scale) at baseline and 6-month follow-up, and social support (Interpersonal Support Evaluation List-12), CSE Scale, and PTS symptoms (Impact of Event Scale-Revised) at 6 months...
February 1, 2024: Psychological Trauma: Theory, Research, Practice and Policy
https://read.qxmd.com/read/38183179/evaluating-the-impact-of-external-forces-on-peripheral-intravenous-catheter-movement-using-ultrasound-a-randomized-pilot-study
#10
JOURNAL ARTICLE
Amit Bahl, Vance Clement, Emily DiLoreto, Nicholas Mielke, Alexandria Carr, Gregory Panza, S Matthew Gibson
BACKGROUND: A major contributor to peripheral intravenous catheter (PIVC) failure may be related to PIVC movement within the vein which is associated with vein wall damage. The magnitude of PIVC movement against the vein wall has not previously been quantified. This study aimed to examine PIVC movement within the vein when minor forces were applied to the PIVC. METHODS: This was a prospective, pilot trial including healthy volunteers in an outpatient research laboratory...
January 5, 2024: Journal of Vascular Access
https://read.qxmd.com/read/38147185/acute-effects-of-ad-libitum-use-of-commercially-available-cannabis-products-on-the-subjective-experience-of-aerobic-exercise-a-crossover-study
#11
JOURNAL ARTICLE
Laurel P Gibson, Gregory R Giordano, L Cinnamon Bidwell, Kent E Hutchison, Angela D Bryan
OBJECTIVE: The present study aimed to examine the acute effects of legal-market cannabis on regular cannabis users' subjective responses to exercise in a controlled laboratory environment. BACKGROUND: Given the stereotype that cannabis is associated with extreme sedentary behavior, there are concerns that cannabis legalization may exacerbate the US physical inactivity epidemic. However, despite these concerns, recent years have seen considerable public interest in the use of cannabis concurrently with exercise (e...
December 26, 2023: Sports Medicine
https://read.qxmd.com/read/38013658/neurologic-morbidity-and-functional-independence-in-adult-survivors-of-childhood-cancer
#12
JOURNAL ARTICLE
Stefanie C Vuotto, Mingjuan Wang, M Fatih Okcu, Daniel C Bowers, Nicole J Ullrich, Kirsten K Ness, Chenghong Li, Deo Kumar Srivastava, Rebecca M Howell, Todd M Gibson, Wendy M Leisenring, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Kevin R Kull, Tara M Brinkman
OBJECTIVE: To examine associations between neurologic late effects and attainment of independence in adult survivors of childhood cancer treated with central nervous system (CNS)-directed therapies. METHODS: A total of 7881 survivors treated with cranial radiation therapy (n = 4051; CRT) and/or intrathecal methotrexate (n = 4193; IT MTX) ([CNS-treated]; median age [range] = 25.5 years [18-48]; time since diagnosis = 17...
November 28, 2023: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/37961298/long-term-in-vivo-three-photon-imaging-reveals-region-specific-differences-in-healthy-and-regenerative-oligodendrogenesis
#13
Michael A Thornton, Gregory L Futia, Michael E Stockton, Samuel A Budoff, Alexandra N Ramirez, Baris Ozbay, Omer Tzang, Karl Kilborn, Alon Poleg-Polsky, Diego Restrepo, Emily A Gibson, Ethan G Hughes
The generation of new myelin-forming oligodendrocytes in the adult CNS is critical for cognitive function and regeneration following injury. Oligodendrogenesis varies between gray and white matter regions suggesting that local cues drive regional differences in myelination and the capacity for regeneration. Yet, the determination of regional variability in oligodendrocyte cell behavior is limited by the inability to monitor the dynamics of oligodendrocytes and their transcriptional subpopulations in white matter of the living brain...
November 1, 2023: bioRxiv
https://read.qxmd.com/read/37942750/the-value-of-whole-body-dual-energy-x-ray-absorptiometry-in-assessing-body-composition-in-patients-with-inflammatory-bowel-disease-a-prospective-study
#14
JOURNAL ARTICLE
Anke L Nguyen, Madhuni Herath, Megan Burns, Darcy Holt, Peter R Ebeling, Frances Milat, Peter R Gibson, Gregory T Moore
OBJECTIVES: Low skeletal muscle index (SMI) is common in inflammatory bowel disease (IBD) but has an uncertain relationship with active intestinal inflammation. This study evaluated body composition by whole-body dual-energy X-ray absorptiometry (DXA) in patients with IBD and healthy controls to enable the value of formal body composition analysis to be judged. METHODS: Patients with IBD and sex/age-matched controls prospectively underwent full body composition assessment by DXA, assessment by BMI, eating questionnaires and handgrip strength...
November 7, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37909388/somatic-tet2-mutations-are-associated-with-giant-cell-arteritis
#15
JOURNAL ARTICLE
Michelle L Robinette, Lachelle D Weeks, Ryan J Kramer, Mridul Agrawal, Christopher J Gibson, Zhi Yu, Aswin Sekar, Arnav Mehta, Abhishek Niroula, Jared T Brown, Gregory C McDermott, Edith R Reshef, Jonathan E Lu, Victor D Liou, Carolina A Chiou, Pradeep Natarajan, Suzanne K Freitag, Deepak A Rao, Benjamin L Ebert
OBJECTIVE: Giant cell arteritis (GCA) is an age-related vasculitis. Prior studies have identified an association between GCA and hematologic malignancies (HM). How the presence of somatic mutations which drive development of HM, or clonal hematopoiesis (CH), may influence clinical outcomes in GCA is not well understood. METHODS: To examine an association between CH and GCA, we analyzed sequenced exomes of 470960 UK Biobank participants for the presence of CH and used multivariable Cox regression...
November 1, 2023: Arthritis & Rheumatology
https://read.qxmd.com/read/37873178/decision-making-time-cells-in-hippocampal-dorsal-ca1
#16
Ming Ma, Fabio Simoes de Souza, Gregory L Futia, Sean R Anderson, Jose Riguero, Daniel Tollin, Arianna Gentile-Polese, Johnathan P Platt, Naoki Hiratani, Emily A Gibson, Diego Restrepo
Sequential neural dynamics encoded by time cells play a crucial role in hippocampal function. However, the role of hippocampal sequential neural dynamics in associative learning is an open question. In this manuscript, we used two-photon Ca2+ imaging of dorsal CA1 pyramidal neurons in head-fixed mice performing a go-no-go associative learning task. We found that pyramidal cells responded differentially to the rewarded or unrewarded stimuli. The stimuli were decoded accurately from the activity of the neuronal ensemble, and accuracy increased substantially as the animal learned to differentiate the stimuli...
October 22, 2023: bioRxiv
https://read.qxmd.com/read/37712340/asthma-and-landscape-fire-smoke-a-thoracic-society-of-australia-and-new-zealand-position-statement
#17
JOURNAL ARTICLE
Vanessa M McDonald, Gregory Archbold, Tesfalidet Beyene, Bronwyn K Brew, Peter Franklin, Peter G Gibson, John Harrington, Philip M Hansbro, Fay H Johnston, Paul D Robinson, Michael Sutherland, Deborah Yates, Graeme R Zosky, Michael J Abramson
Landscape fires are increasing in frequency and severity globally. In Australia, extreme bushfires cause a large and increasing health and socioeconomic burden for communities and governments. People with asthma are particularly vulnerable to the effects of landscape fire smoke (LFS) exposure. Here, we present a position statement from the Thoracic Society of Australia and New Zealand. Within this statement we provide a review of the impact of LFS on adults and children with asthma, highlighting the greater impact of LFS on vulnerable groups, particularly older people, pregnant women and Aboriginal and Torres Strait Islander peoples...
September 15, 2023: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/37632144/biologics-mepolizumab-and-omalizumab-induced-remission-in-severe-asthma-patients
#18
JOURNAL ARTICLE
Dennis Thomas, Vanessa M McDonald, Sean Stevens, Erin S Harvey, Melissa Baraket, Philip Bardin, Jeffrey J Bowden, Simon Bowler, Jimmy Chien, Li Ping Chung, Andrew Gillman, Mark Hew, Sandra Hodge, Alan James, Christine Jenkins, Constance H Katelaris, Gregory P Katsoulotos, David Langton, Joy Lee, Guy Marks, Matthew Peters, Naghmeh Radhakrishna, Paul N Reynolds, Janet Rimmer, Pathmanathan Sivakumaran, John W Upham, Peter Wark, Ian A Yang, Peter G Gibson
BACKGROUND: Asthma remission has emerged as a potential treatment goal. This study evaluated the effectiveness of two biologics (mepolizumab/omalizumab) in achieving asthma remission. METHODS: This observational study included 453 severe asthma patients (41% male; mean age ± SD 55.7 ± 14.7 years) from two real-world drug registries: the Australian Mepolizumab Registry and the Australian Xolair Registry. The composite outcome clinical remission was defined as zero exacerbations and zero oral corticosteroids during the previous 6 months assessed at 12 months and 5-item Asthma Control Questionnaire (ACQ-5) ≤1 at 12 months...
August 25, 2023: Allergy
https://read.qxmd.com/read/37614575/cardiovascular-risk-factor-disparities-in-adult-survivors-of-childhood-cancer-compared-with-the-general-population
#19
JOURNAL ARTICLE
David H Noyd, Qi Liu, Yutaka Yasui, Eric J Chow, Smita Bhatia, Paul C Nathan, Andrew P Landstrom, Emily Tonorezos, Jacqueline Casillas, Amy Berkman, Kirsten K Ness, Daniel A Mulrooney, Wendy M Leisenring, Carrie R Howell, Jamie Shoag, Anne Kirchhoff, Rebecca M Howell, Todd M Gibson, Leah L Zullig, Gregory T Armstrong, Kevin C Oeffinger
BACKGROUND: It is unknown whether a history of childhood cancer modifies the established disparities in cardiovascular risk factors (CVRFs) observed in the general population. OBJECTIVES: We sought to determine if disparities in CVRFs by race/ethnicity are similar among childhood cancer survivors compared with the general population. METHODS: The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort with a longitudinal follow-up of 24,084 5-year survivors diagnosed between 1970 and 1999...
August 2023: JACC CardioOncology
https://read.qxmd.com/read/37599724/a-daily-diary-investigation-of-cannabis-use-and-its-diet-and-exercise-correlates
#20
JOURNAL ARTICLE
Laurel P Gibson, Carillon J Skrzynski, Gregory R Giordano, Angela D Bryan
BACKGROUND: The increasing availability of legal-market cannabis products has raised many questions about potential harms and benefits of increased use. In particular, concerns have been raised about the possible negative impact of cannabis use on behavioral determinants of obesity and chronic disease, including diet and exercise. However, previous research is mixed and has largely relied on cross-sectional survey data and coarse measurements of cannabis use, underscoring the need for more rigorous research designs...
2023: Frontiers in Psychology
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