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https://www.readbyqxmd.com/read/29053929/characterizing-workforces-exposed-to-current-and-emerging-non-carbonaceous-nanomaterials-in-the-u-s
#1
Kelsey R Babik, Matthew M Dahm, Kevin H Dunn, Kevin L Dunn, Mary K Schubauer-Berigan
OBJECTIVE: Toxicology studies suggest that exposure to certain types of engineered nanomaterials (ENMs) may cause adverse health effects, but little is known about the workforce in the United States that produces or uses these materials. In addition, occupational exposure control strategies in this industry are not well characterized. This study identified US ENM manufacturers and users (other than carbon nanotubes and nanofibers, which have been characterized elsewhere), determined workforce size, characterized types and quantities of materials used, occupational exposure control strategies, and the feasibility of occupational ENM exposure studies...
October 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29053868/lagos-ne-a-multi-scaled-geospatial-and-temporal-database-of-lake-ecological-context-and-water-quality-for-thousands-of-u-s-lakes
#2
Patricia A Soranno, Linda C Bacon, Michael Beauchene, Karen E Bednar, Edward G Bissell, Claire K Boudreau, Marvin G Boyer, Mary T Bremigan, Stephen R Carpenter, Jamie W Carr, Kendra S Cheruvelil, Samuel T Christel, Matt Claucherty, Sarah M Collins, Joseph D Conroy, John A Downing, Jed Dukett, C Emi Fergus, Christopher T Filstrup, Clara Funk, Maria J Gonzalez, Linda T Green, Corinna Gries, John D Halfman, Stephen K Hamilton, Paul C Hanson, Emily N Henry, Elizabeth M Herron, Celeste Hockings, James R Jackson, Kari Jacobson-Hedin, Lorraine L Janus, William W Jones, John R Jones, Caroline M Keson, Katelyn B S King, Scott A Kishbaugh, Jean-Francois Lapierre, Barbara Lathrop, Jo A Latimore, Yuehlin Lee, Noah R Lottig, Jason A Lynch, Leslie J Matthews, William H McDowell, Karen E B Moore, Brian P Neff, Sarah J Nelson, Samantha K Oliver, Michael L Pace, Donald C Pierson, Autumn C Poisson, Amina I Pollard, David M Post, Paul O Reyes, Donald O Rosenberry, Karen M Roy, Lars G Rudstam, Orlando Sarnelle, Nancy J Schuldt, Caren E Scott, Nicholas K Skaff, Nicole J Smith, Nick R Spinelli, Joseph J Stachelek, Emily H Stanley, John L Stoddard, Scott B Stopyak, Craig A Stow, Jason M Tallant, Pang-Ning Tan, Anthony P Thorpe, Michael J Vanni, Tyler Wagner, Gretchen Watkins, Kathleen C Weathers, Katherine E Webster, Jeffrey D White, Marcy K Wilmes, Shuai Yuan
Background: Understanding the factors that affect water quality and the ecological services provided by freshwater ecosystems is an urgent global environmental issue. Predicting how water quality will respond to global changes not only requires water quality data, but also information about the ecological context of individual water bodies across broad spatial extents. Because lake water quality is usually sampled in limited geographic regions, often for limited time periods, assessing the environmental controls of water quality requires compilation of many datasets across broad regions and across time into an integrated database...
October 19, 2017: GigaScience
https://www.readbyqxmd.com/read/29053783/systematic-assessment-of-multiple-routine-and-near-real-time-indicators-to-classify-the-severity-of-influenza-seasons-and-pandemics-in-the-united-states-2003-04-through-2015-2016
#3
Matthew Biggerstaff, Krista Kniss, Daniel B Jernigan, Lynnette Brammer, Joseph Bresee, Shikha Garg, Erin Burns, Carrie Reed
Assessments of influenza season severity can guide public health action. We used the Moving Epidemic Method to develop intensity thresholds (IT) for 3 US surveillance indicators from the 2003-04-2014-15 influenza season (excluding the 2009 pandemic): 1) outpatient visits for influenza-like illness, 2) influenza-related hospitalizations, and 3) influenza- and pneumonia-related deaths. ITs were developed for the overall population and children, adults, and older adults separately and were the upper limit of the 50% (IT50), 90% (IT90), and 98% (IT98) one-sided CIs of the geometric mean of each season's 3 highest values...
October 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29053524/nursing-humanities-teaching-for-a-sense-of-salience
#4
Fidelindo Lim, Matthew John Marsaglia
Reports have indicated that nursing programs in the United States are not generally effective in teaching nursing science, natural science, the social sciences, and the humanities. The value of the lifelong study of humanities for nurses is the invitation for contemplation on the human experience so we can make informed moral, spiritual, and intellectual sense of the world. In essence, when we understand, we become more empathetic. This article adds to the call for teaching for a sense of salience in nursing through the meaningful synthesis of humanities in baccalaureate education...
October 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29053377/substance-use-among-bi-multiracial-youth-in-the-united-states-profiles-of-psychosocial-risk-and-protection
#5
Trenette Clark Goings, Christopher P Salas-Wright, Matthew O Howard, Michael G Vaughn
BACKGROUND: Bi/multiracial youth face higher risk of engaging in substance use than most monoracial youth. OBJECTIVES: This study contrasts the prevalence of substance use among bi/multiracial youth with that of youth from other racial/ethnic groups, and identifies distinct profiles of bi/multiracial youth by examining their substance use risk. METHODS: Using data from the National Survey on Drug Use and Health (collected between 2002 and 2014), we analyze data for 9,339 bi/multiracial youth ages 12-17 living in the United States...
October 20, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29052618/a-role-for-prefrontal-cortical-nmda-receptors-in-murine-alcohol-heightened-aggression
#6
Emily L Newman, Miho Terunuma, Tiffany Wang, Nishani Hewage, Matthew B Bicakci, Stephen J Moss, Joseph F DeBold, Klaus A Miczek
Alcohol is associated with nearly half of all violent crimes committed in the United States; yet, a potential neural basis for this type of pathological aggression remains elusive. Alcohol may act on NMDA receptors (NMDARs) within cortical circuits to impede processing and to promote aggression. Here, male mice were characterized as alcohol-heightened (AHAs) or alcohol non-heightened aggressors (ANAs) during resident-intruder confrontations after self-administering 1.0 g/kg alcohol (6% w/v) or water. Alcohol produced a pathological-like pattern of aggression in AHAs; these mice shifted their bites to more vulnerable locations on the body of a submissive animal, including the anterior back and ventrum after consuming alcohol...
October 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29052259/molecular-switches-for-any-ph-a-systematic-study-of-the-versatile-coordination-behaviour-of-cyclam-scorpionands
#7
Yu Heng Lau, Jack K Clegg, Jason R Price, Rene B Marquart, Matthew H Todd, Peter J Rutledge
Molecular switches have many potential applications in nanoscience and biomedicine. Transition metal complexes that can be switched from an unreactive state to an active one by a simple change in conditions (e.g. pH shift) or by binding to a specific biomolecular target - so-called target-activated metal complexes (TAMCs) - hold particular allure as a means of harnessing the potent but at times indiscriminate reactivity of metal-based drugs. We have prepared a series of ten structurally related ligands each of which bears a different pendant side-arm functional group off a common macrocyclic core...
October 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29052102/changes-in-cerebellar-functional-connectivity-and-autonomic-regulation-in-cancer-patients-treated-with-the-neuro-emotional-technique-for-traumatic-stress-symptoms
#8
Daniel A Monti, Anna Tobia, Marie Stoner, Nancy Wintering, Michael Matthews, Chris J Conklin, Feroze B Mohamed, Inna Chervoneva, Andrew B Newberg
PURPOSE: A growing number of research studies have implicated the cerebellum in emotional processing and regulation, especially with regard to negative emotional memories. However, there currently are no studies showing functional changes in the cerebellum as a result of treatment for traumatic stress symptoms. The Neuro Emotional Technique (NET) is an intervention designed to help improve symptoms related to traumatic stress using an integrative approach that combines emotional, cognitive, and motor processing, with a particular focus on autonomic nervous system regulation...
October 19, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29049297/functional-connectivity-structure-of-cortical-calcium-dynamics-in-anesthetized-and-awake-mice
#9
Patrick W Wright, Lindsey M Brier, Adam Q Bauer, Grant A Baxter, Andrew W Kraft, Matthew D Reisman, Annie R Bice, Abraham Z Snyder, Jin-Moo Lee, Joseph P Culver
The interplay between hemodynamic-based markers of cortical activity (e.g. fMRI and optical intrinsic signal imaging), which are an indirect and relatively slow report of neural activity, and underlying synaptic electrical and metabolic activity through neurovascular coupling is a topic of ongoing research and debate. As application of resting state functional connectivity measures is extended further into topics such as brain development, aging and disease, the importance of understanding the fundamental physiological basis for functional connectivity will grow...
2017: PloS One
https://www.readbyqxmd.com/read/29048965/the-effectiveness-of-hiv-prevention-interventions-in-socioeconomically-disadvantaged-ethnic-minority-women-a-systematic-review-and-meta-analysis
#10
Isabel Ruiz-Perez, Matthew Murphy, Guadalupe Pastor-Moreno, Antonio Rojas-García, Miguel Rodríguez-Barranco
BACKGROUND: Surveys in the United States and Europe have shown a plateau of new HIV cases, with certain regions and populations disproportionately affected by the disease. Ethnic minority women and socioeconomically disadvantaged groups are disproportionately affected by HIV. Previous reviews have focused on prevention interventions targeting ethnic minority men who have sex with men, have not accounted for socioeconomic status, or have included only interventions carried out in clinical settings...
October 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29048962/integrating-hiv-surveillance-and-field-services-data-quality-and-care-continuum-in-king-county-washington-2010-2015
#11
Julia E Hood, David A Katz, Amy B Bennett, Susan E Buskin, Julia C Dombrowski, Stephen E Hawes, Matthew R Golden
OBJECTIVES: To assess how integration of HIV surveillance and field services might influence surveillance data and linkage to care metrics. METHODS: We used HIV surveillance and field services data from King County, Washington, to assess potential impact of misclassification of prior diagnoses on numbers of new diagnoses. The relationship between partner services and linkage to care was evaluated with multivariable log-binomial regression models. RESULTS: Of the 2842 people who entered the King County HIV Surveillance System in 2010 to 2015, 52% were newly diagnosed, 41% had a confirmed prior diagnosis in another state, and 7% had an unconfirmed prior diagnosis...
October 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29048957/loaded-handgun-carrying-among-us-adults-2015
#12
Ali Rowhani-Rahbar, Deborah Azrael, Vivian H Lyons, Joseph A Simonetti, Matthew Miller
OBJECTIVES: To determine the frequency of loaded handgun carrying among US adult handgun owners, characterize those who carry, and examine concealed carrying by state concealed carry laws. METHODS: Using a nationally representative survey of US adults in 2015, we asked handgun owners (n = 1444) about their past-30-day carrying behavior. RESULTS: Among surveyed handgun owners, 24% (95% confidence interval[CI] = 21%, 26%) carried loaded handguns monthly, of whom 35% (95% CI = 29%, 41%) did so daily; 82% (95% CI = 77%, 86%) carried primarily for protection...
October 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29048348/analysis-of-a-community-pharmacy-intervention-to-improve-low-adherence-rates-to-oral-diabetes-medications
#13
Jerica Singleton, Stevie Veach, Christine Catney, Matthew Witry
For patients with diabetes, suboptimal medication adherence contributes to disease progression, complications, and increased healthcare costs. Identification of, and intervention for patient-identified reasons for nonadherence are essential to improving medication adherence. This prospective, quality improvement study was conducted at an independent community pharmacy in the Mid-West United States. Patients with a proportion of days covered (PDC) for their oral antidiabetic medications of less than 80% were contacted by telephone and interviewed by a clinical pharmacist...
October 19, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29046570/general-ecological-models-for-human-subsistence-health-and-poverty
#14
Calistus N Ngonghala, Giulio A De Leo, Mercedes M Pascual, Donald C Keenan, Andrew P Dobson, Matthew H Bonds
The world's rural poor rely heavily on their immediate natural environment for subsistence and suffer high rates of morbidity and mortality from infectious diseases. We present a general framework for modelling subsistence and health of the rural poor by coupling simple dynamic models of population ecology with those for economic growth. The models show that feedbacks between the biological and economic systems can lead to a state of persistent poverty. Analyses of a wide range of specific systems under alternative assumptions show the existence of three possible regimes corresponding to a globally stable development equilibrium, a globally stable poverty equilibrium and bistability...
August 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/29044185/structural-analysis-of-variant-of-helicobacter-pylori-motb-in-its-activated-form-engineered-as-chimera-of-motb-and-leucine-zipper
#15
Daniel A Andrews, Yuri E Nesmelov, Matthew C Wilce, Anna Roujeinikova
Rotation of the bacterial flagellum is powered by a proton influx through the peptidoglycan (PG)-tethered stator ring MotA/B. MotA and MotB form an inner-membrane complex that does not conduct protons and does not bind to PG until it is inserted into the flagellar motor. The opening of the proton channel involves association of the plug helices in the periplasmic region of the MotB dimer into a parallel coiled coil. Here, we have characterised the structure of a soluble variant of full-length Helicobacter pylori MotB in which the plug helix was engineered to be locked in a parallel coiled coil state, mimicking the open state of the stator...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042570/fan-out-estimation-in-spin-based-quantum-computer-scale-up
#16
Thien Nguyen, Charles D Hill, Lloyd C L Hollenberg, Matthew R James
Solid-state spin-based qubits offer good prospects for scaling based on their long coherence times and nexus to large-scale electronic scale-up technologies. However, high-threshold quantum error correction requires a two-dimensional qubit array operating in parallel, posing significant challenges in fabrication and control. While architectures incorporating distributed quantum control meet this challenge head-on, most designs rely on individual control and readout of all qubits with high gate densities. We analysed the fan-out routing overhead of a dedicated control line architecture, basing the analysis on a generalised solid-state spin qubit platform parameterised to encompass Coulomb confined (e...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29041475/sub-shot-noise-shadow-sensing-with-quantum-correlations
#17
Ermes Toninelli, Matthew P Edgar, Paul-Antoine Moreau, Graham M Gibson, Giles D Hammond, Miles J Padgett
The quantised nature of the electromagnetic field sets the classical limit to the sensitivity of position measurements. However, techniques based on the properties of quantum states can be exploited to accurately measure the relative displacement of a physical object beyond this classical limit. In this work, we use a simple scheme based on the split-detection of quantum correlations to measure the position of a shadow at the single-photon light level, with a precision that exceeds the shot-noise limit. This result is obtained by analysing the correlated signals of bi-photon pairs, created in parametric downconversion and detected by an electron multiplying CCD (EMCCD) camera employed as a split-detector...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29039999/treatment-and-survival-of-childhood-neuroblastoma-evidence-from-a-population-based-study-in-the-united-states
#18
Dairmuid Coughlan, Matthew Gianferante, Charles F Lynch, Jennifer L Stevens, Linda C Harlan
BACKGROUND: Childhood neuroblastoma describes a heterogeneous group of extracranial solid tumors, that are treated per risk profile. We sought to describe treatment patterns and survival using population-based data from throughout the United States. MATERIALS AND METHODS: Using the National Cancer Institute (NCI)'s Patterns of Care data, we analyzed treatment provided to newly diagnosed, histologically confirmed neuroblastoma patients in 2010 and 2011, registered to one of 14 Surveillance, Epidemiology, and End Results (SEER) cancer registries...
October 17, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29039180/heart-failure-and-long-term-survival-among-older-women-with-breast-cancer
#19
Jordan Harrison, Christopher Friese, Debra Barton, Nancy Janz, Susan Pressler, Matthew Davis
Objectives: To evaluate the association between heart failure and overall survival up to 10 years after breast cancer diagnosis. Sample & Setting: Women aged 65 years or older diagnosed with invasive breast cancer, with and without self-reported heart failure, were examined for this retrospective cohort study using Surveillance, Epidemiology, and End Results cancer registries in the United States. Methods & Variables: Cox proportional hazards regression was used to examine the association between heart failure status and mortality, adjusting for comorbidity and other clinical or sociodemographic differences...
January 2, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29038582/direct-visualization-of-critical-hydrogen-atoms-in-a-pyridoxal-5-phosphate-enzyme
#20
Steven Dajnowicz, Ryne C Johnston, Jerry M Parks, Matthew P Blakeley, David A Keen, Kevin L Weiss, Oksana Gerlits, Andrey Kovalevsky, Timothy C Mueser
Enzymes dependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin B6) perform a myriad of diverse chemical transformations. They promote various reactions by modulating the electronic states of PLP through weak interactions in the active site. Neutron crystallography has the unique ability of visualizing the nuclear positions of hydrogen atoms in macromolecules. Here we present a room-temperature neutron structure of a homodimeric PLP-dependent enzyme, aspartate aminotransferase, which was reacted in situ with α-methylaspartate...
October 16, 2017: Nature Communications
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