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Matthew State

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https://www.readbyqxmd.com/read/29655642/estimating-medicare-and-patient-savings-from-the-use-of-bevacizumab-for-the-treatment-of-exudative-age-related-macular-degeneration
#1
Philip J Rosenfeld, Matthew A Windsor, William J Feuer, Sissi J J Sun, Kevin D Frick, Eric A Swanson, David Huang
PURPOSE: The Medicare cost savings from the use of bevacizumab in the United States for the treatment of exudative age-related macular degeneration (AMD) were estimated by replacing the use of bevacizumab with ranibizumab and aflibercept. DESIGN: Retrospective trend study. METHODS: Main outcome measures were spending by Medicare as tracked by Current Procedural Terminology (CPT) codes for intravitreal injections (67028) and treatment-specific J-codes (J0178, J2778, J9035, J3490 and J3590) for inhibitors of vascular endothelial growth factor...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29653354/a-self-tuned-graph-based-framework-for-localization-and-grading-prostate-cancer-lesions-an-initial-evaluation-based-on-multiparametric-magnetic-resonance-imaging
#2
Weifu Chen, Mingquan Lin, Eli Gibson, Matthew Bastian-Jordan, Derek W Cool, Zahra Kassam, Huageng Liang, Guocan Feng, Aaron D Ward, Bernard Chiu
Multiparametric magnetic resonance imaging (mpMRI) has been established as the state-of-the-art examination for the detection and localization of prostate cancer lesions. Prostate Imaging-Reporting and Data System (PI-RADS) has been established as a scheme to standardize the reporting of mpMRI findings. Although lesion delineation and PI-RADS ratings could be performed manually, human delineation and ratings are subjective and time-consuming. In this article, we developed and validated a self-tuned graph-based model for PI-RADS rating prediction...
April 3, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29653304/a-review-of-the-pharmaceutical-exposome-in-aquatic-fauna
#3
REVIEW
Thomas H Miller, Nicolas R Bury, Stewart F Owen, James I MacRae, Leon P Barron
Pharmaceuticals have been considered 'contaminants of emerging concern' for more than 20 years. In that time, many laboratory studies have sought to identify hazard and assess risk in the aquatic environment, whilst field studies have searched for targeted candidates and occurrence trends using advanced analytical techniques. However, a lack of a systematic approach to the detection and quantification of pharmaceuticals has provided a fragmented literature of serendipitous approaches. Evaluation of the extent of the risk for the plethora of human and veterinary pharmaceuticals available requires the reliable measurement of trace levels of contaminants across different environmental compartments (water, sediment, biota - of which biota has been largely neglected)...
April 10, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29652400/emission-beyond-4-%C3%AE-m-and-mid-infrared-lasing-in-a-dysprosium-doped-indium-fluoride-inf-3-fiber
#4
Matthew R Majewski, Robert I Woodward, Jean-Yves Carreé, Samuel Poulain, Marcel Poulain, Stuart D Jackson
Optical emission from rare-earth-doped fluoride fibers has thus far been limited to less than 4 μm. We extend emission beyond this limit by employing an indium fluoride (InF3 ) glass fiber as the host, which exhibits an increased infrared transparency over commonly used zirconium fluoride (ZBLAN). Near-infrared pumping of a dysprosium-doped InF3 fiber results in broad emission centered around 4.3 μm, representing the longest emission yet achieved from a fluoride fiber. The first laser emission in an InF3 fiber is also demonstrated from the 3 μm dysprosium transition...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29651998/high-resolution-local-field-potentials-measured-with-deep-brain-stimulation-arrays
#5
Simeng Zhang, Allison T Connolly, Lauren Madden, Jerrold L Vitek, Matthew D Johnson
Local field potential (LFP) recordings along a deep brain stimulation (DBS) lead can provide useful feedback for titrating DBS therapy. However, conventional DBS leads with four cylindrical macroelectrodes likely undersample the spatial distribution of sinks and sources in a given brain region. In this study, we investigated the spectral power and spatial feature sizes of LFP activity in non-human primate subthalamic nucleus and globus pallidus using chronically implanted 32-channel directional DBS arrays.
 
 Approach: Subthalamic nucleus and globus pallidus LFP signals were recorded from directional DBS arrays in the resting state and during a reach-and-retrieval task in two non-human primates in naïve and parkinsonian conditions...
April 13, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29651359/preclinical-labor-and-delivery-shadowing-the-impact-on-medical-students-perceptions-of-obstetrics-and-gynecology
#6
Sarah Dotters-Katz, Alexis Panzer, Matthew Givens, Marcela Smid, Alice Chuang
Objective  We sought to determine the impact of preclinical exposure (shadowing) to labor and delivery (L&D) on medical students' perceptions of obstetrics and gynecology (OB/GYN). Study Design  We administered a written survey to rising third-year medical students at a single center prior to any clerkship. We described motivation/deterrents for shadowing among students, and experiences/perceptions of those students who shadowed. Results  In total, 119/136 (86%) students completed the survey. Of those, 29% participated in shadowing on L&D...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29651167/constraining-relativistic-bow-shock-properties-in-rotation-powered-millisecond-pulsar-binaries
#7
Zorawar Wadiasingh, Alice K Harding, Christo Venter, Markus Böttcher, Matthew G Baring
Multiwavelength followup of unidentified Fermi sources has vastly expanded the number of known galactic-field "black widow" and "redback" millisecond pulsar binaries. Focusing on their rotation-powered state, we interpret the radio to X-ray phenomenology in a consistent framework. We advocate the existence of two distinct modes differing in their intrabinary shock orientation, distinguished by the phase-centering of the double-peaked X-ray orbital modulation originating from mildly-relativistic Doppler boosting...
April 20, 2017: Astrophysical Journal
https://www.readbyqxmd.com/read/29651124/the-effects-of-sampling-location-and-predictor-point-estimate-certainty-on-posterior-support-in-bayesian-phylogeographic-generalized-linear-models
#8
Daniel Magee, Jesse E Taylor, Matthew Scotch
The use of generalized linear models in Bayesian phylogeography has enabled researchers to simultaneously reconstruct the spatiotemporal history of a virus and quantify the contribution of predictor variables to that process. However, little is known about the sensitivity of this method to the choice of the discrete state partition. Here we investigate this question by analyzing a data set containing 299 sequences of the West Nile virus envelope gene sampled in the United States and fifteen predictors aggregated at four spatial levels...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650757/conformational-flexibility-within-the-nascent-polypeptide-associated-complex-enables-its-interactions-with-structurally-diverse-client-proteins
#9
Esther M Martin, Matthew P Jackson, Martin Gamerdinger, Karina Gense, Theodoros K Karamanos, Julia R Humes, Elke Deuerling, Alison E Ashcroft, Sheena E Radford
As newly synthesized polypeptides emerge from the ribosome, it is crucial that they fold correctly. To prevent premature aggregation, nascent chains interact with chaperones that facilitate folding or prevent misfolding until protein synthesis is complete. Nascent polypeptide-associated complex (NAC) is a ribosome-associated chaperone important for protein homeostasis. However, how NAC binds its substrates remains unclear. Using native electrospray ionization MS (ESI MS), limited proteolysis, NMR and cross-linking, we analysed the conformational properties of NAC from Caenorhabditis elegans and studied its ability to bind proteins in different conformational states...
April 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29649631/simultaneous-risk-factor-control-using-telehealth-to-slow-progression-of-diabetic-kidney-disease-stop-dkd-study-protocol-and-baseline-characteristics-of-a-randomized-controlled-trial
#10
Clarissa J Diamantidis, Hayden B Bosworth, Megan M Oakes, Clemontina A Davenport, Jane F Pendergast, Sejal Patel, Jivan Moaddeb, Huiman X Barnhart, Peter D Merrill, Khaula Baloch, Matthew J Crowley, Uptal D Patel
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the United States. Multiple risk factors contribute to DKD development, yet few interventions target more than a single DKD risk factor at a time. This manuscript describes the study protocol, recruitment, and baseline participant characteristics for the Simultaneous Risk Factor Control Using Telehealth to slOw Progression of Diabetic Kidney Disease (STOP-DKD) study. The STOP-DKD study is a randomized controlled trial designed to evaluate the effectiveness of a multifactorial behavioral and medication management intervention to mitigate kidney function decline at 3 years compared to usual care...
April 9, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29645346/identification-of-a-siglec-f-granulocyte-macrophage-progenitor
#11
Jessica E Bolden, Erin C Lucas, Geyu Zhou, Jeremy A O'Sullivan, Carolyn A de Graaf, Mark D McKenzie, Ladina Di Rago, Tracey M Baldwin, Jake Shortt, Warren S Alexander, Bruce S Bochner, Matthew E Ritchie, Douglas J Hilton, Kirsten A Fairfax
In recent years multi-parameter flow cytometry has enabled identification of cells at major stages in myeloid development; from pluripotent hematopoietic stem cells, through populations with increasingly limited developmental potential (common myeloid progenitors and granulocyte-macrophage progenitors), to terminally differentiated mature cells. Myeloid progenitors are heterogeneous, and the surface markers that define transition states from progenitors to mature cells are poorly characterized. Siglec-F is a surface glycoprotein frequently used in combination with IL-5 receptor alpha (IL5Rα) for the identification of murine eosinophils...
April 12, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29643510/intra-tumour-diversification-in-colorectal-cancer-at-the-single-cell-level
#12
Sophie F Roerink, Nobuo Sasaki, Henry Lee-Six, Matthew D Young, Ludmil B Alexandrov, Sam Behjati, Thomas J Mitchell, Sebastian Grossmann, Howard Lightfoot, David A Egan, Apollo Pronk, Niels Smakman, Joost van Gorp, Elizabeth Anderson, Stephen J Gamble, Chris Alder, Marc van de Wetering, Peter J Campbell, Michael R Stratton, Hans Clevers
Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of intra-tumour diversification, we characterized organoids derived from multiple single cells from three colorectal cancers as well as from adjacent normal intestinal crypts. Colorectal cancer cells showed extensive mutational diversification and carried several times more somatic mutations than normal colorectal cells...
April 11, 2018: Nature
https://www.readbyqxmd.com/read/29642590/characterizing-phage-genomes-for-therapeutic-applications
#13
Casandra W Philipson, Logan J Voegtly, Matthew R Lueder, Kyle A Long, Gregory K Rice, Kenneth G Frey, Biswajit Biswas, Regina Z Cer, Theron Hamilton, Kimberly A Bishop-Lilly
Multi-drug resistance is increasing at alarming rates. The efficacy of phage therapy, treating bacterial infections with bacteriophages alone or in combination with traditional antibiotics, has been demonstrated in emergency cases in the United States and in other countries, however remains to be approved for wide-spread use in the US. One limiting factor is a lack of guidelines for assessing the genomic safety of phage candidates. We present the phage characterization workflow used by our team to generate data for submitting phages to the Federal Drug Administration (FDA) for authorized use...
April 10, 2018: Viruses
https://www.readbyqxmd.com/read/29642433/spatially-correlated-single-nanomaterial-level-structural-and-optical-profiling-of-cu-doped-zno-nanorods-synthesized-via-multifunctional-silicides
#14
Johnson Truong, Matthew Hansen, Brian Szychowski, Tian Xie, Marie-Christine Daniel, Jong-In Hahm
We demonstrate a straightforward and effective method to synthesize vertically oriented, Cu-doped ZnO nanorods (NRs) using a novel multipurpose platform of copper silicide nanoblocks (Cu₃Si NBs) preformed laterally in well-defined directions on Si. The use of the surface-organized Cu₃Si NBs for ZnO NR growth successfully results in densely assembled Cu-doped ZnO NRs on each NB platform, whose overall structures resemble thick bristles on a brush head. We show that Cu₃Si NBs can uniquely serve as a catalyst for ZnO NRs, a local dopant source of Cu, and a prepatterned guide to aid the local assembly of the NRs on the growth substrate...
April 7, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29629471/energy-transfer-and-photoluminescence-properties-of-lanthanide-containing-polyoxotitanate-cages-coordinated-by-salicylate-ligands
#15
Ning Li, Gomathy Sandhya Subramanian, Peter D Matthews, James Xiao, Vijila Chellappan, Timothy E Rosser, Erwin Reisner, He-Kuan Luo, Dominic S Wright
Polyoxotitanate (POT) cages have attracted considerable attention recently; much of this from the fact that they can be considered to be structural models for the technologically important semiconductor TiO2. Among the reported POT cages, lanthanide-containing (Ln-POT) cages are of particular interest owing to the fascinating luminescence properties of Ln3+ ions and the versatile coordination environments that they can adopt. In the present study, we report the energy transfer mechanism and photoluminescence properties of a series of isostructural Ln-POT cages coordinated by salicylate ligands, of general formula [LnTi6O3(OiPr)9(salicylate)6] (Ln-1, Ln = La to Er excluding Pm)...
April 9, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29629434/contextualizing-naturalistic-driving-data-in-a-rural-state-among-drivers-with-and-without-obstructive-sleep-apnea
#16
Jeffrey D Dawson, Elizabeth Bair, Nazan Askan, Kelly Sewell, Jon Tippin, Matthew Rizzo
In naturalistic studies, Global Positioning System (GPS) data and date/time stamps can link driver exposure to specific environments (e.g., road types, speed limits, night driving, etc.), providing valuable context for analyzing critical events, such as crashes, near crashes, and breaches of accelerometer limits. In previous work, we showed how to automate this contextualization, using GPS data obtained at 1 Hz and merging this with Geographic Information Systems (GIS) databases maintained by the Iowa Department of Transportation (DOT)...
June 2017: Proceedings of the ... International Driving Symposium on Human Factors in Driver Assessment, Training, and Vehicle Design
https://www.readbyqxmd.com/read/29627714/circulating-endocannabinoids-and-affect-regulation-in-human-subjects
#17
Emil F Coccaro, Matthew N Hill, Lauren Robinson, Royce J Lee
The endocannabinoid (EC) system influences a wide variety of neurobiological processes including affect and emotionality as well as other neuropsychiatric functions. In this study we examined the relationship of circulating endocannabinoids [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)] with affect and emotionality in 175 individuals with (n = 115) and without (n = 60) mood, anxiety, and/or personality disorders. Circulating AEA levels displayed a modest, though statistically significant, inverse relationship with a composite measure of affect regulation (β = - 0...
March 16, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29626741/prescription-opioid-misusing-chronic-pain-patients-exhibit-dysregulated-context-dependent-associations-investigating-associative-learning-in-addiction-with-the-cue-primed-reactivity-task
#18
Eric L Garland, Craig J Bryan, Lydia Kreighbaum, Yoshio Nakamura, Matthew O Howard, Brett Froeliger
BACKGROUND: Associative learning undergirds the development of addiction, such that drug-related cues serve as conditioned stimuli to elicit drug-seeking responses. Plausibly, among opioid misusing chronic pain patients, pain-related information may serve as a conditioned stimulus to magnify opioid cue-elicited autonomic and craving responses through a process of second-order conditioning. METHODS: We utilized a novel psychophysiological probe of pain-opioid conditioned associations, the Cue-Primed Reactivity (CPR) task...
March 27, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29626083/the-pseudokinase-domain-of-saccharomyces-cerevisiae-tra1-is-required-for-nuclear-localization-and-incorporation-into-the-saga-and-nua4-complexes
#19
Matthew D Berg, Julie Genereaux, Jim Karagiannis, Christopher J Brandl
Tra1 is an essential component of the SAGA/SLIK and NuA4 complexes in S. cerevisiae , recruiting these co-activator complexes to specific promoters. As a PIKK family member, Tra1 is characterized by a C-terminal phosphoinositide 3-kinase (PI3K) domain. Unlike other PIKK family members (e.g. Tor1, Tor2, Mec1, Tel1), Tra1 has no demonstrable kinase activity. We identified three conserved arginine residues in Tra1 that reside proximal or within the cleft between the N- and C-terminal subdomains of the PI3K domain...
April 6, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29625744/long-term-7-or-more-years-outcomes-of-the-sleeve-gastrectomy-a-meta-analysis
#20
Benjamin Clapp, Matthew Wynn, Colin Martyn, Chase Foster, Montana O'Dell, Alan Tyroch
BACKGROUND: The laparoscopic sleeve gastrectomy is now the most common bariatric operation in the United States and has become an established procedure in the armamentarium of the bariatric surgeon. However, this has happened without the strong support of long-term outcomes data, namely the rate of revision and durability of the weight loss. Newly published data from around the world are starting to show alarming trends in these 2 areas. This paper will examine the published and presented data with at least a 7-year follow-up...
March 6, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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