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Matthew State

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https://www.readbyqxmd.com/read/28549428/rheumatoid-factors-do-not-predict-cardiovascular-disease-and-mortality-in-the-general-population-in-the-busselton-health-survey
#1
Johannes Nossent, Warren Raymond, Mark Divitini, Matthew Knuiman
BACKGROUND: Rheumatoid Factors (RF) are antibodies directed against the Fc portion of IgG and are involved in clearance of immune complexes. While RF can develop in a wide range of conditions, higher RF levels indicate a greater risk for a severe disease course in Rheumatoid Arthritis (RA) patients including cardiovascular complications and premature death. We investigated whether RF also constitute a risk factor for these outcomes in the general population. METHODS: We included 2,323 participants (46% male, mean age 50 years) free of CVD at baseline in 1972...
May 26, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28548499/polyoxovanadate-alkoxide-clusters-as-a-redox-reservoir-for-iron
#2
Feng Li, Stephanie H Carpenter, Robert F Higgins, Mark G Hitt, William W Brennessel, Maryline G Ferrier, Samantha K Cary, Juan S Lezama-Pacheco, Joshua T Wright, Benjamin W Stein, Matthew P Shores, Michael L Neidig, Stosh A Kozimor, Ellen M Matson
Inspired by the multielectron redox chemistry achieved using conventional organic-based redox-active ligands, we have characterized a series of iron-functionalized polyoxovanadate-alkoxide clusters in which the metal oxide scaffold functions as a three-dimensional, electron-deficient metalloligand. Four heterometallic clusters were prepared through sequential reduction, demonstrating that the metal oxide scaffold is capable of storing up to four electrons. These reduced products were characterized by cyclic voltammetry, IR, electronic absorption, and (1)H NMR spectroscopies...
May 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28548150/using-%C3%AE-2-rheology-to-quantify-rheological-properties-during-repeated-reversible-phase-transitions-of-soft-matter
#3
Matthew D Wehrman, Melissa J Milstrey, Seth Lindberg, Kelly M Schultz
A microfluidic device is designed to measure repeated phase transitions, gelation and degradation, on a single sample by exchanging the surrounding fluid while minimizing shear stress. This device enables quantitative microrheological characterization of material properties over multiple phase transitions, determining whether the material returns to the same equilibrium state. Fluid exchange is accomplished by using a two layer design, the sample is trapped in the first layer and the second layer is a well for the exchanging fluid...
May 26, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28548097/scalable-focused-ion-beam-creation-of-nearly-lifetime-limited-single-quantum-emitters-in-diamond-nanostructures
#4
Tim Schröder, Matthew E Trusheim, Michael Walsh, Luozhou Li, Jiabao Zheng, Marco Schukraft, Alp Sipahigil, Ruffin E Evans, Denis D Sukachev, Christian T Nguyen, Jose L Pacheco, Ryan M Camacho, Edward S Bielejec, Mikhail D Lukin, Dirk Englund
The controlled creation of defect centre-nanocavity systems is one of the outstanding challenges for efficiently interfacing spin quantum memories with photons for photon-based entanglement operations in a quantum network. Here we demonstrate direct, maskless creation of atom-like single silicon vacancy (SiV) centres in diamond nanostructures via focused ion beam implantation with ∼32 nm lateral precision and <50 nm positioning accuracy relative to a nanocavity. We determine the Si+ ion to SiV centre conversion yield to be ∼2...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28547993/conformational-heterogeneity-and-dna-recognition-by-the-morphogen-bicoid
#5
Ramkrishna Adhikary, Yun Xuan Tan, Jian Liu, Jörg Zimmermann, Matthew Holcomb, Carolyn Yvellez, Philip E Dawson, Floyd E Romesberg
The morphogenic activity of the Drosophila transcription factor bicoid (Bcd), the first morphogenic protein identified, is controlled by its DNA binding homeodomain. Homeodomains mediate developmental processes in all multicellular organisms, but the Bcd homeodomain appears to be unique as it can bind multiple DNA sequences and even RNA. All homeodomain proteins adopt a three-helix fold, with residues of the third helix mediating recognition of the nucleic acid target via interactions with the major groove...
May 26, 2017: Biochemistry
https://www.readbyqxmd.com/read/28544637/prevalence-of-autism-spectrum-disorder-and-autistic-symptoms-in-a-school-based-cohort-of-children-in-kolkata-india
#6
Alokananda Rudra, Matthew K Belmonte, Parmeet Kaur Soni, Saoni Banerjee, Shaneel Mukerji, Bhismadev Chakrabarti
Despite housing ∼18% of the world's population, India does not yet have an estimate of prevalence of autism. This study was carried out to estimate the prevalence of autism in a selected population of school-children in India. N = 11,849 children (mean age = 5.9 [SD = 1.3], 39.5% females) were selected from various school types from three boroughs in Kolkata, India. Parents/caregivers and teachers filled in the social and communication disorders checklist (SCDC). Children meeting cutoff on parent-reported SCDC were followed up with the social communication questionnaire (SCQ)...
May 25, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28544467/a-survey-on-the-beliefs-and-knowledge-of-gout-management-in-new-medical-graduates-new-south-wales-australia
#7
Matthew Terrill, John Riordan
AIM: To assess the beliefs and knowledge of gout management in new medical graduates. METHOD: A survey on gout management was sent to new medical graduates during their orientation week, New South Wales, Australia. RESULTS: Of 15 hospital networks, 11 agreed to participate. From these, 168 graduates responded (23.7% response rate). Most (81.1%) felt that gout was a serious disease, 51.2% answered that they had been taught adequately to manage acute gout, only 37...
May 25, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28543740/global-regulatory-requirements-for-mutagenicity-assessment-in-the-registration-of-industrial-chemicals
#8
REVIEW
Zhiying Ji, Nicholas S Ball, Matthew J LeBaron
Mutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). Here we compile the mutagenicity testing requirements for registration of industrial chemicals from representative geographic regions (in alphabetical order), that is Australia, Brazil, Canada, China, European Union (EU), India, Japan, South Korea, Taiwan, and United States (US)...
May 25, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28542682/applicant-perspectives-on-the-otolaryngology-residency-application-process
#9
Matthew Ward, Christian Pingree, Adrienne M Laury, Sarah N Bowe
Importance: It has been nearly 25 years since medical students were queried regarding their perspectives on otolaryngology-head and neck surgery (OHNS) residency selection. Understanding this viewpoint is critical to improving the current application process. Objective: To evaluate the perceptions of 2016 OHNS residency applicants regarding the application process and offer suggestions for reform. Design, Setting, and Participants: In this cross-sectional study of anonymous online survey data, a 14-question survey was designed based on resources obtained from a computerized PubMed, Ovid, and GoogleScholar database search of the English language from January 1, 1990, through December 31, 2015, was conducted using the following search terms: (medical student OR applicant) AND (application OR match) AND otolaryngology...
May 25, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28542603/a-conformational-switch-high-throughput-screening-assay-and-allosteric-inhibition-of-the-flavivirus-ns2b-ns3-protease
#10
Matthew Brecher, Zhong Li, Binbin Liu, Jing Zhang, Cheri A Koetzner, Adham Alifarag, Susan A Jones, Qishan Lin, Laura D Kramer, Hongmin Li
The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages by host and viral proteases in order to produce the individual proteins that constitute an infectious virion. Previous studies have revealed that the NS2B cofactor of the viral NS2B-NS3 heterocomplex protease displays a conformational dynamic between active and inactive states. Here, we developed a conformational switch assay based on split luciferase complementation (SLC) to monitor the conformational change of NS2B and to characterize candidate allosteric inhibitors...
May 25, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28542013/location-modification-factors-for-potential-dose-estimation
#11
Sandra F Snyder, J Matthew Barnett
A U.S. Department of Energy facility must comply with the National Emission Standard for Hazardous Air Pollutants for radioactive air emissions. The standard is an effective dose of less than 0.1 mSv y to the maximum public receptor. Additionally, a lower dose level may be assigned to a specific emission point in a State issued permit. A method to efficiently estimate the expected dose for future emissions is described. This method is most appropriately applied to a research facility with several emission points with generally low emission levels of numerous isotopes...
July 2017: Health Physics
https://www.readbyqxmd.com/read/28540866/electrophysiological-signatures-of-atypical-intrinsic-brain-connectivity-networks-in-autism
#12
Guofa Shou, Matthew W Mosconi, Jun Wang, Lauren E Ethridge, John A Sweeney, Lei Ding
OBJECTIVE: Abnormal local and long-range brain connectivity have been widely reported in autism spectrum disorder (ASD), yet the nature of these abnormalities and their functional relevance at distinct cortical rhythms remains unknown. Investigations of intrinsic connectivity networks (ICNs) and their coherence across whole brain networks hold promise for determining whether patterns of functional connectivity abnormalities vary across frequencies and networks in ASD. In the present study, we aimed to probe atypical intrinsic brain connectivity networks in ASD from resting-state electroencephalography (EEG) data via characterizing the whole brain network...
May 25, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28540162/effect-of-brand-and-advertising-medium-on-demand-for-e-cigarettes-evidence-from-an-experimental-auction
#13
Matthew C Rousu, Richard O'Connor, Jay Corrigan
Print and television advertisements for e-cigarettes are currently legal in the United States. Given that e-cigarettes are a lower-risk alternative to cigarettes, these ads could have a positive public health impact if they motivate smokers to switch to e-cigarettes. However, the public health impact of e-cigarette ads could be negative if ads increase demand for both e-cigarettes and cigarettes. We use experimental auctions -in which participants bid in real auctions and winners pay for the items they purchase - to study the effect of print and TV e-cigarettes ads on demand for the brand from the ad, for another e-cigarettes brand, and for cigarettes...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28539451/reducing-v3-antigenicity-and-immunogenicity-on-soluble-native-like-hiv-1-env-sosip-trimers
#14
Rajesh P Ringe, Gabriel Ozorowski, Kimmo Rantalainen, Weston B Struwe, Katie Matthews, Jonathan L Torres, Anila Yasmeen, Christopher A Cottrell, Thomas J Ketas, Celia C LaBranche, David C Montefiori, Albert Cupo, Max Crispin, Ian A Wilson, Andrew B Ward, Rogier W Sanders, P J Klasse, John P Moore
Native-like trimers of the SOSIP design are being developed as immunogens in human immunodeficiency virus type 1 (HIV-1) vaccine development programs. These trimers display the epitopes for multiple broadly neutralizing antibodies (bNAbs), but can also expose binding sites for some types of non-neutralizing antibodies (non-NAbs). Among the latter are epitopes in the gp120 V3 region that are highly immunogenic when SOSIP trimers are evaluated in animal models. It is presently uncertain whether antibodies against V3 can interfere with the induction of NAbs, but there are good arguments in favor of suppressing such "off-target" immune responses...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28536030/lot-to-lot-consistency-safety-and-immunogenicity-of-3-lots-of-haemophilus-influenzae-type-b-conjugate-vaccine-results-from-a-phase-iii-randomized-multicenter-study-in-infants
#15
Nicola P Klein, Remon Abu-Elyazeed, Matthew Cornish, Michael L Leonardi, Leonard B Weiner, Peter E Silas, Stanley E Grogg, Meera Varman, Robert W Frenck, Brigitte Cheuvart, Yaela Baine, Jacqueline M Miller, Maarten Leyssen, Narcisa Mesaros, Sumita Roy-Ghanta
BACKGROUND: Vaccination against Haemophilus influenzae type b (Hib) is included in routine pediatric immunization schedule in the United States. Previous vaccine shortages have created the need for additional options for Hib vaccination. METHODS: This phase III, randomized, multi-centered study (NCT01000974) evaluated the safety and immunogenicity of a monovalent tetanus toxoid-conjugate Hib vaccine (Hib-TT) compared to a monovalent (Hib-TT control) and a combination Hib-TT vaccine...
May 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28535374/discovery-of-stromal-regulatory-networks-that-suppress-ras-sensitized-epithelial-cell-proliferation
#16
Huayang Liu, James A Dowdle, Safiya Khurshid, Nicholas J Sullivan, Nicholas Bertos, Komal Rambani, Markus Mair, Piotr Daniel, Esther Wheeler, Xing Tang, Kyle Toth, Michael Lause, Markus E Harrigan, Karl Eiring, Connor Sullivan, Matthew J Sullivan, Serena W Chang, Siddhant Srivastava, Joseph S Conway, Raleigh Kladney, Joseph McElroy, Sooin Bae, Yuanzhi Lu, Ali Tofigh, Sadiq M I Saleh, Soledad A Fernandez, Jeffrey D Parvin, Vincenzo Coppola, Erin R Macrae, Sarmila Majumder, Charles L Shapiro, Lisa D Yee, Bhuvaneswari Ramaswamy, Michael Hallett, Michael C Ostrowski, Morag Park, Helen M Chamberlin, Gustavo Leone
Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a Caenorhabditis elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adjacent Ras pathway-sensitized epithelial cells. These candidates encode components of protein complexes and signaling pathways that converge on the control of chromatin dynamics, cytoplasmic polyadenylation, and translation...
May 22, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28535334/maximizing-the-photocatalytic-activity-of-metal-organic-frameworks-with-aminated-functionalized-linkers-sub-stoichiometric-effects-in-mil-125-nh2
#17
Matthew Chambers, Xia Wang, Laura Ellezam, Ovidiu Ersen, Marc Fontecave, Clément Sanchez, Laurence Rozes, Caroline Mellot-Draznieks
Despite the promise of utilizing metal-organic frameworks (MOFs) as highly tunable photocatalytic materials, systematic studies that interrogate the relationship between their catalytic performances and the amount of function-alized linkers are lacking. Aminated linkers are known to enhance the absorption of light and afford photocatalysis with MOFs under visible-light irradiation. However, the manner in which the photocatalytic performances are impacted by the amount of such linkers is poorly understood. Here, we assess the photocatalytic activity of MIL-125, a TiO2/1,4-benzenedicarboxylate (bdc) MOF for the oxidation of benzyl alcohol to benzaldehyde when increasing amounts of bdc-NH2 linkers (0%, 20%, 46%, 70% and 100%) are incorporated in the framework...
May 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28535093/the-effects-of-crushed-ice-ingestion-prior-to-steady-state-exercise-in-the-heat
#18
Matthew Zimmermann, Grant Landers, Karen E Wallman, Jacinta Saldaris
This study examined the physiological effects of crushed ice ingestion before steady state exercise in the heat. Ten healthy males with age (23 ± 3 y), height (176.9 ± 8.7 cm), body-mass (73.5 ± 8.0 kg), VO2peak (48.5 ± 3.6 mL∙kg∙min(-1)) participated in the study. Participants completed 60 min of cycling at 55% of their VO2peak preceded by 30 min of precooling whereby 7 g∙kg(-1) of thermoneutral water (CON) or crushed ice (ICE) was ingested. The reduction in Tc at the conclusion of precooling was greater in ICE (-0...
June 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28534414/estimating-pm2-5-concentrations-in-the-conterminous-united-states-using-the-random-forest-approach
#19
Xuefei Hu, Jessica Hartmann Belle, Xia Meng, Avani Wildani, Lance Waller, Matthew Strickland, Yang Liu
To estimate PM2.5 concentrations, many parametric regression models have been developed, while non-parametric machine learning algorithms are used less often and national-scale models are rare. In this paper, we develop a random forest model incorporating Aerosol Optical Depth (AOD) data, meteorological fields, and land use variables to estimate daily 24-hour averaged ground level PM2.5 concentrations over the conterminous United States in 2011. Random forests are an ensemble learning method that provides predictions with high accuracy and interpretability...
May 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28533955/among-site-variability-in-the-stochastic-dynamics-of-east-african-coral-reefs
#20
Katherine A Allen, John F Bruno, Fiona Chong, Damian Clancy, Tim R McClanahan, Matthew Spencer, Kamila Żychaluk
Coral reefs are dynamic systems whose composition is highly influenced by unpredictable biotic and abiotic factors. Understanding the spatial scale at which long-term predictions of reef composition can be made will be crucial for guiding conservation efforts. Using a 22-year time series of benthic composition data from 20 reefs on the Kenyan and Tanzanian coast, we developed Bayesian vector autoregressive state-space models for reef dynamics, incorporating among-site variability, and quantified their long-term behaviour...
2017: PeerJ
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