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https://www.readbyqxmd.com/read/27862758/efficient-transfection-of-sirna-by-peptide-dendrimer-lipid-conjugates
#1
Albert Kwok, Gabriela A Eggimann, Marc Heitz, Jean-Louis Reymond, Florian Hollfelder, Tamis Darbre
Efficient delivery of small interfering RNA (siRNA) into cells is the basis of target-gene-specific silencing and, ultimately, gene therapy. However, current transfection reagents are relatively inefficient, and very few studies provide the sort of systematic understanding based on structure-activity relationships that would provide rationales for their improvement. This work established peptide dendrimers (administered with cationic lipids) as siRNA transfection reagents and recorded structure-activity relationships that highlighted the importance of positive charge distribution in the two outer layers and a hydrophobic core as key features for efficient performance...
November 9, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27829648/cuba-s-strategy-for-alzheimer-disease-and-dementia-syndromes
#2
Rodolfo I Bosch-Bayard, Juan J Llibre-Rodríguez, Alberto Fernández-Seco, Carmen Borrego-Calzadilla, Mayra R Carrasco-García, Tania Zayas-Llerena, Carmen R Moreno-Carbonell, Ana G Reymond-Vasconcelos
Dementia is a great challenge to public health in Cuba due to its impact on society and families. Cuba's National Intervention Strategy for Alzheimer Disease and Dementia Syndromes is designed to address this challenge. The Strategy includes working guidelines for primary and secondary care, education about rights of people with cognitive impairment, professional development, research, and health promotion and dementia prevention. An associated action plan, focused on primary care, includes proposals for creation of memory clinics, day centers and comprehensive rehabilitation services for cognitive stimulation...
October 2016: MEDICC Review
https://www.readbyqxmd.com/read/27799067/identification-of-a-rai1-associated-disease-network-through-integration-of-exome-sequencing-transcriptomics-and-3d-genomics
#3
Maria Nicla Loviglio, Christine R Beck, Janson J White, Marion Leleu, Tamar Harel, Nicolas Guex, Anne Niknejad, Weimin Bi, Edward S Chen, Isaac Crespo, Jiong Yan, Wu-Lin Charng, Shen Gu, Ping Fang, Zeynep Coban-Akdemir, Chad A Shaw, Shalini N Jhangiani, Donna M Muzny, Richard A Gibbs, Jacques Rougemont, Ioannis Xenarios, James R Lupski, Alexandre Reymond
BACKGROUND: Smith-Magenis syndrome (SMS) is a developmental disability/multiple congenital anomaly disorder resulting from haploinsufficiency of RAI1. It is characterized by distinctive facial features, brachydactyly, sleep disturbances, and stereotypic behaviors. METHODS: We investigated a cohort of 15 individuals with a clinical suspicion of SMS who showed neither deletion in the SMS critical region nor damaging variants in RAI1 using whole exome sequencing. A combination of network analysis (co-expression and biomedical text mining), transcriptomics, and circularized chromatin conformation capture (4C-seq) was applied to verify whether modified genes are part of the same disease network as known SMS-causing genes...
November 1, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27758847/central-metabolic-changes-in-o3-and-herbivory-affect-photosynthesis-and-stomatal-closure
#4
Stefano Papazian, Eliezer Khaling, Christelle Bonnet, Steve Lassueur, Philippe Reymond, Thomas Moritz, James Blande, Benedicte Riber Albrectsen
Plants have evolved adaptive mechanisms that allow them to tolerate a continuous range of abiotic and biotic stressors. Tropospheric ozone (O3), a global anthropogenic pollutant, directly affects living organisms and ecosystems, including plant-herbivore interactions. In this study, we investigate the stress responses of wild black mustard (Brassica nigra) exposed consecutively to O3 and the specialist herbivore Pieris brassicae. Transcriptomics and metabolomics data were evaluated using multivariate, correlation, and network analyses for the O3 and herbivory responses...
October 6, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27703984/efficacy-and-safety-of-a-permethrin-fipronil-spot-on-solution-effitix%C3%A2-in-dogs-naturally-infested-by-ticks-in-europe
#5
Christelle Navarro, Nadège Reymond, Nolwenn Crastes, Stéphane Bonneau
Effitix is a new broad spectrum product based on the combination of fipronil 6.1% and permethrin 54.5% in a solution for spot-on application. It has been shown to be safe and efficacious in dogs in controlling tick, flea, sandfly, and mosquito infestations in laboratory conditions. The aim of this controlled, randomised study was to assess its safety and efficacy against natural tick infestations in field conditions. One hundred eighty-two privately owned dogs were included in France and Germany: 123 dogs were treated on day 0 with the permethrin-fipronil combination (Effitix) and 59 with a permethrin-imidacloprid combination (Advantix®)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27678344/pressurized-intraperitoneal-aerosol-chemotherapy-pipac-as-a-neoadjuvant-therapy-before-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#6
Ramy Girshally, Cedric Demtröder, Nurettin Albayrak, Jürgen Zieren, Clemens Tempfer, Marc A Reymond
BACKGROUND: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel drug delivery system able to induce regression of peritoneal metastasis (PM) in the salvage situation. The aim of this study was to determine the clinical characteristics, tumor histology, and extent of disease of the patients having undergone cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) after "neoadjuvant" PIPAC. METHODS: This study was performed at a single institution, tertiary center...
September 27, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27664307/-the-mobile-paediatric-circulatory-support-unit
#7
Alain Amblard, Marie Reymond, Sandrine Champrenault, Pierre-Louis Leger, Jérôme Rambaud
A mobile paediatric circulatory support unit has been set up within the paediatric and neonatal intensive care service at the Armand-Trousseau Hospital in Paris (AP-HP, 75). It is in place for situations of refractory respiratory and/or circulatory failure and can intervene in a radius of several hundred kilometres, in order to establish long-term extracorporeal circulation. In this delicate context, transporting children requires specific skills, coordination between all intervening parties and faultless organisation...
September 2016: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/27639313/lung-adenocarcinomas-correlation-of-computed-tomography-and-pathology-findings
#8
J G Cohen, E Reymond, A Jankowski, E Brambilla, F Arbib, S Lantuejoul, G R Ferretti
Adenocarcinoma is the most common histologic type of lung cancer. Recent lung adenocarcinoma classifications from the International Association for the Study of Lung cancer, the American Thoracic Society and the European Respiratory Society (IASLC/ETS/ERS, 2011) and World Health Organization (WHO, 2015) define a wide range of adenocarcinoma types and subtypes featuring different prognosis and management. This spectrum of lesions translates into various CT presentations and features, which generally show good correlation with histopathology, stressing the key role of the radiologist in the diagnosis and management of those patients...
October 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27602486/synthetic-studies-toward-the-c14-c29-fragment-of-mirabalin
#9
Johan Cornil, Pierre-Georges Echeverria, Sébastien Reymond, Phannarath Phansavath, Virginie Ratovelomanana-Vidal, Amandine Guérinot, Janine Cossy
A convergent synthesis of one isomer of the C14-C29 fragment of mirabalin is disclosed. The key steps include a Marshall allenylation, a Mukaiyama aldol reaction and a Crimmins aldolization, which allow the control of 10 out of 25 stereogenic centers present in the molecule.
September 16, 2016: Organic Letters
https://www.readbyqxmd.com/read/27588455/gnb5-mutations-cause-an-autosomal-recessive-multisystem-syndrome-with-sinus-bradycardia-and-cognitive-disability
#10
Elisabeth M Lodder, Pasquelena De Nittis, Charlotte D Koopman, Wojciech Wiszniewski, Carolina Fischinger Moura de Souza, Najim Lahrouchi, Nicolas Guex, Valerio Napolioni, Federico Tessadori, Leander Beekman, Eline A Nannenberg, Lamiae Boualla, Nico A Blom, Wim de Graaff, Maarten Kamermans, Dario Cocciadiferro, Natascia Malerba, Barbara Mandriani, Zeynep Hande Coban Akdemir, Richard J Fish, Mohammad K Eldomery, Ilham Ratbi, Arthur A M Wilde, Teun de Boer, William F Simonds, Marguerite Neerman-Arbez, V Reid Sutton, Fernando Kok, James R Lupski, Alexandre Reymond, Connie R Bezzina, Jeroen Bakkers, Giuseppe Merla
No abstract text is available yet for this article.
September 1, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27581012/quantitative-analysis-of-human-cancer-cell-extravasation-using-intravital-imaging
#11
Lian Willetts, David Bond, Konstantin Stoletov, John D Lewis
Metastasis, or the spread of cancer cells from a primary tumor to distant sites, is the leading cause of cancer-associated death. Metastasis is a complex multi-step process comprised of invasion, intravasation, survival in circulation, extravasation, and formation of metastatic colonies. Currently, in vitro assays are limited in their ability to investigate these intricate processes and do not faithfully reflect metastasis as it occurs in vivo. Traditional in vivo models of metastasis are limited by their ability to visualize the seemingly sporadic behavior of where and when cancer cells spread (Reymond et al...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27542596/dynamic-changes-of-tumor-gene-expression-during-repeated-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-in-women-with-peritoneal-cancer
#12
Günther A Rezniczek, Friederike Jüngst, Hendrik Jütte, Andrea Tannapfel, Ziad Hilal, Lukas A Hefler, Marc-André Reymond, Clemens B Tempfer
BACKGROUND: Intraperitoneal chemotherapy is used to treat peritoneal cancer. The pattern of gene expression changes of peritoneal cancer during intraperitoneal chemotherapy has not been studied before. Pressurized intraperitoneal aerosol chemotherapy is a new form of intraperitoneal chemotherapy using repeated applications and allowing repeated tumor sampling during chemotherapy. Here, we present the analysis of gene expression changes during pressurized intraperitoneal aerosol chemotherapy with doxorubicin and cisplatin using a 22-gene panel...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27531712/extension-of-human-lncrna-transcripts-by-race-coupled-with-long-read-high-throughput-sequencing-race-seq
#13
Julien Lagarde, Barbara Uszczynska-Ratajczak, Javier Santoyo-Lopez, Jose Manuel Gonzalez, Electra Tapanari, Jonathan M Mudge, Charles A Steward, Laurens Wilming, Andrea Tanzer, Cédric Howald, Jacqueline Chrast, Alicia Vela-Boza, Antonio Rueda, Francisco J Lopez-Domingo, Joaquin Dopazo, Alexandre Reymond, Roderic Guigó, Jennifer Harrow
Long non-coding RNAs (lncRNAs) constitute a large, yet mostly uncharacterized fraction of the mammalian transcriptome. Such characterization requires a comprehensive, high-quality annotation of their gene structure and boundaries, which is currently lacking. Here we describe RACE-Seq, an experimental workflow designed to address this based on RACE (rapid amplification of cDNA ends) and long-read RNA sequencing. We apply RACE-Seq to 398 human lncRNA genes in seven tissues, leading to the discovery of 2,556 on-target, novel transcripts...
August 17, 2016: Nature Communications
https://www.readbyqxmd.com/read/27523599/gnb5-mutations-cause-an-autosomal-recessive-multisystem-syndrome-with-sinus-bradycardia-and-cognitive-disability
#14
Elisabeth M Lodder, Pasquelena De Nittis, Charlotte D Koopman, Wojciech Wiszniewski, Carolina Fischinger Moura de Souza, Najim Lahrouchi, Nicolas Guex, Valerio Napolioni, Federico Tessadori, Leander Beekman, Eline A Nannenberg, Lamiae Boualla, Nico A Blom, Wim de Graaff, Maarten Kamermans, Dario Cocciadiferro, Natascia Malerba, Barbara Mandriani, Zeynep Hande Coban Akdemir, Richard J Fish, Mohammad K Eldomery, Ilham Ratbi, Arthur A M Wilde, Teun de Boer, William F Simonds, Marguerite Neerman-Arbez, V Reid Sutton, Fernando Kok, James R Lupski, Alexandre Reymond, Connie R Bezzina, Jeroen Bakkers, Giuseppe Merla
GNB5 encodes the G protein β subunit 5 and is involved in inhibitory G protein signaling. Here, we report mutations in GNB5 that are associated with heart-rate disturbance, eye disease, intellectual disability, gastric problems, hypotonia, and seizures in nine individuals from six families. We observed an association between the nature of the variants and clinical severity; individuals with loss-of-function alleles had more severe symptoms, including substantial developmental delay, speech defects, severe hypotonia, pathological gastro-esophageal reflux, retinal disease, and sinus-node dysfunction, whereas related heterozygotes harboring missense variants presented with a clinically milder phenotype...
September 1, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27487209/emergence-of-a-homo-sapiens-specific-gene-family-and-chromosome-16p11-2-cnv-susceptibility
#15
Xander Nuttle, Giuliana Giannuzzi, Michael H Duyzend, Joshua G Schraiber, Iñigo Narvaiza, Peter H Sudmant, Osnat Penn, Giorgia Chiatante, Maika Malig, John Huddleston, Chris Benner, Francesca Camponeschi, Simone Ciofi-Baffoni, Holly A F Stessman, Maria C N Marchetto, Laura Denman, Lana Harshman, Carl Baker, Archana Raja, Kelsi Penewit, Nicolette Janke, W Joyce Tang, Mario Ventura, Lucia Banci, Francesca Antonacci, Joshua M Akey, Chris T Amemiya, Fred H Gage, Alexandre Reymond, Evan E Eichler
Genetic differences that specify unique aspects of human evolution have typically been identified by comparative analyses between the genomes of humans and closely related primates, including more recently the genomes of archaic hominins. Not all regions of the genome, however, are equally amenable to such study. Recurrent copy number variation (CNV) at chromosome 16p11.2 accounts for approximately 1% of cases of autism and is mediated by a complex set of segmental duplications, many of which arose recently during human evolution...
August 11, 2016: Nature
https://www.readbyqxmd.com/read/27464907/bigchem-challenges-and-opportunities-for-big-data-analysis-in-chemistry
#16
Igor V Tetko, Ola Engkvist, Uwe Koch, Jean-Louis Reymond, Hongming Chen
The increasing volume of biomedical data in chemistry and life sciences requires the development of new methods and approaches for their handling. Here, we briefly discuss some challenges and opportunities of this fast growing area of research with a focus on those to be addressed within the BIGCHEM project. The article starts with a brief description of some available resources for "Big Data" in chemistry and a discussion of the importance of data quality. We then discuss challenges with visualization of millions of compounds by combining chemical and biological data, the expectations from mining the "Big Data" using advanced machine-learning methods, and their applications in polypharmacology prediction and target de-convolution in phenotypic screening...
December 2016: Molecular Informatics
https://www.readbyqxmd.com/read/27444697/-prediction-of-the-efficiency-of-endoscopic-lung-volume-reduction-by-valves-in-severe-emphysema
#17
V Bocquillon, A Briault, E Reymond, F Arbib, A Jankowski, G Ferretti, C Pison
INTRODUCTION: In severe emphysema, endoscopic lung volume reduction with valves is an alternative to surgery with less morbidity and mortality. In 2015, selection of patients who will respond to this technique is based on emphysema heterogeneity, a complete fissure visible on the CT-scan and absence of collateral ventilation between lobes. Our case report highlights that individualized prediction is possible. CASE REPORT: A 58-year-old woman had severe, disabling pulmonary emphysema...
July 18, 2016: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/27420907/fluorogenic-probes-for-multicolor-imaging-in-living-cells
#18
Gražvydas Lukinavičius, Luc Reymond, Keitaro Umezawa, Olivier Sallin, Elisa D'Este, Fabian Göttfert, Haisen Ta, Stefan W Hell, Yasuteru Urano, Kai Johnsson
Here we present a far-red, silicon-rhodamine-based fluorophore (SiR700) for live-cell multicolor imaging. SiR700 has excitation and emission maxima at 690 and 715 nm, respectively. SiR700-based probes for F-actin, microtubules, lysosomes, and SNAP-tag are fluorogenic, cell-permeable, and compatible with superresolution microscopy. In conjunction with probes based on the previously introduced carboxy-SiR650, SiR700-based probes permit multicolor live-cell superresolution microscopy in the far-red, thus significantly expanding our capacity for imaging living cells...
August 3, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27402902/new-quality-measure-for-snp-array-based-cnv-detection
#19
A Macé, M A Tuke, J S Beckmann, L Lin, Jacquemont S, M N Weedon, A Reymond, Z Kutalik
MOTIVATION: Only a few large systematic studies have evaluated the impact of copy number variants (CNVs) on common diseases. Several million individuals have been genotyped on SNP arrays, which could be used for genome-wide CNVs association studies. However, CNV calls remain prone to false positives and only empirical filtering strategies exist in the literature. To overcome this issue, we defined a new quality score (QS) estimating the probability of a CNV called by PennCNV to be confirmed by other software...
July 10, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27391133/discovery-of-a-selective-aurora-a-kinase-inhibitor-by-virtual-screening
#20
Falco Kilchmann, Maria J Marcaida, Sachin Kotak, Thomas Schick, Silvan D Boss, Mahendra Awale, Pierre Gönczy, Jean-Louis Reymond
Here we report the discovery of a selective inhibitor of Aurora A, a key regulator of cell division and potential anticancer target. We used the atom category extended ligand overlap score (xLOS), a 3D ligand-based virtual screening method recently developed in our group, to select 437 shape and pharmacophore analogs of reference kinase inhibitors. Biochemical screening uncovered two inhibitor series with scaffolds unprecedented among kinase inhibitors. One of them was successfully optimized by structure-based design to a potent Aurora A inhibitor (IC50 = 2 nM) with very high kinome selectivity for Aurora kinases...
August 11, 2016: Journal of Medicinal Chemistry
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