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https://www.readbyqxmd.com/read/29678749/benefit-of-bet-v-1-contiguous-overlapping-peptide-immunotherapy-persists-during-first-follow-up-season
#1
Alexander Kettner, Gilles DellaCorte, Fréderic de Blay, Lars Jacobsen, Marek Jutel, Margitta Worm, Vincent Charlon, Kim Simonsen, Christophe Reymond, François Spertini
A short course of 5 injection AIT with Bet v 1 Contiguous Overlapping Peptides was well tolerated and improved allergic rhinitis during the 2nd pollen season after treatment. Long lasting efficacy was associated with a persistent allergen-specific IgG4 response.
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29643205/in-vitro-iclip-based-modeling-uncovers-how-the-splicing-factor-u2af2-relies-on-regulation-by-cofactors
#2
F X Reymond Sutandy, Stefanie Ebersberger, Lu Huang, Anke Busch, Maximilian Bach, Hyun-Seo Kang, Jörg Fallmann, Daniel Maticzka, Rolf Backofen, Peter F Stadler, Kathi Zarnack, Michael Sattler, Stefan Legewie, Julian König
Alternative splicing generates distinct mRNA isoforms and is crucial for proteome diversity in eukaryotes. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it recognizes 3' splice sites and recruits the spliceosome. We establish "in vitro iCLIP" experiments, in which recombinant RBPs are incubated with long transcripts, to study how U2AF2 recognizes RNA sequences and how this is modulated by trans -acting RBPs. We measure U2AF2 affinities at hundreds of binding sites and compare in vitro and in vivo binding landscapes by mathematical modeling...
April 11, 2018: Genome Research
https://www.readbyqxmd.com/read/29579323/identification-of-potent-and-selective-small-molecule-inhibitors-of-the-cation-channel-trpm4
#3
Lijo Cherian Ozhathil, Clémence Delalande, Beatrice Bianchi, Gabor Nemeth, Sven Kappel, Urs Thomet, Daniela Ross-Kaschitza, Céline Simonin, Matthias Rubin, Jürg Gertsch, Martin Lochner, Christine Peinelt, Jean-Louis Reymond, Hugues Abriel
BACKGROUND AND PURPOSE: TRPM4 is a calcium-activated nonselective cation channel expressed in many tissues and implicated in several diseases, and has not yet been validated as a therapeutic target due to the lack of potent and selective inhibitors. We sought to discover a novel series of small-molecule inhibitor by combining in silico methods and cell based screening assay, with sub-micromolar potency and improved selectivity from previously reported TRPM4 inhibitors. EXPERIMENTAL APPROACH: Here, we developed a HTS compatible assay to record TRPM4-mediated Na+ influx in cells using a Na+ -sensitive dye and used this assay to screen a small set of compounds selected by ligand-based virtual screening using previously known weakly active and non-selective TRPM4 inhibitors as seed molecules...
March 26, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29574807/a-glycosyl-transferase-family-43-protein-involved-in-xylan-biosynthesis-is-associated-with-straw-digestibility-in-brachypodium-distachyon
#4
Caragh Whitehead, Francisco J Ostos Garrido, Matthieu Reymond, Rachael Simister, Assaf Distelfeld, Sergio G Atienza, Fernando Piston, Leonardo D Gomez, Simon J McQueen-Mason
The recalcitrance of secondary plant cell walls to digestion constrains biomass use for the production of sustainable bioproducts and for animal feed. We screened a population of Brachypodium recombinant inbred lines (RILs) for cell wall digestibility using commercial cellulases and detected a quantitative trait locus (QTL) associated with this trait. Examination of the chromosomal region associated with this QTL revealed a candidate gene that encodes a putative glycosyl transferase family (GT) 43 protein, orthologue of IRX14 in Arabidopsis, and hence predicted to be involved in the biosynthesis of xylan...
March 25, 2018: New Phytologist
https://www.readbyqxmd.com/read/29526367/multicenter-comprehensive-methodological-and-technical-analysis-of-832-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-interventions-performed-in-349-patients-for-peritoneal-carcinomatosis-treatment-an-international-survey-study
#5
Maciej Nowacki, Mohammad Alyami, Laurent Villeneuve, Frederic Mercier, Martin Hubner, Wouter Willaert, Wim Ceelen, Marc Reymond, Denis Pezet, Catherine Arvieux, Vladimir Khomyakov, Laura Lay, Sergio Gianni, Wojciech Zegarski, Naoual Bakrin, Olivier Glehen
BACKGROUND: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new drug delivery method offered in selected patients suffering from non-resectable peritoneal carcinomatosis (PC). As reported experience is still limited, we conducted a survey among active PIPAC centers aiming to report their technical approach and clinical findings. METHODS: An online survey was sent to active PIPAC centers worldwide. The questionnaire consisted of 34 closed questions and was conducted over a period of 3 months beginning in March 2017...
February 22, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29523716/retraction
#6
Philippe Reymond
No abstract text is available yet for this article.
March 9, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29501553/bold-signal-in-sensorimotor-regions-reveals-differential-encoding-of-passive-forefinger-velocity-and-displacement-amplitude
#7
Julio Dueñas, James Sulzer, Philipp Stämpfli, Marie-Claude Hepp-Reymond, Spyros Kollias, Erich Seifritz, Roger Gassert
Peripheral encoding of movement kinematics has been well-characterized, but there is little understanding of the relationship between movement kinematics and associated brain activation. We hypothesized that kinematics of passive movement is differentially represented in the sensorimotor network, reflecting the well-studied afferent responses to movement. A robotic forefinger manipulandum was used to induce passive kinematic stimuli and monitor interaction force in 41 healthy participants during whole-brain functional magnetic resonance imaging (fMRI)...
February 28, 2018: NeuroImage
https://www.readbyqxmd.com/read/29490798/deep-learning-invades-drug-design-and-synthesis
#8
Josep Arús-Pous, Daniel Probst, Jean-Louis Reymond
No abstract text is available yet for this article.
February 1, 2018: Chimia
https://www.readbyqxmd.com/read/29477490/ct-texture-analysis-of-subsolid-nodules-for-differentiating-invasive-from-in-situ-and-minimally-invasive-lung-adenocarcinoma-subtypes
#9
J G Cohen, E Reymond, M Medici, M Lederlin, S Lantuejoul, F Laurent, A C Toffart, A Moreau-Gaudry, A Jankowski, G R Ferretti
PURPOSE: The purpose of this study was to evaluate the usefulness of computed tomography-texture analysis (CTTA) in differentiating between in-situ and minimally-invasive from invasive adenocarcinomas in subsolid lung nodules (SSLNs). MATERIAL AND METHODS: Two radiologists retrospectively reviewed 49 SSLNs in 44 patients. There were 27 men and 17 women with a mean age of 63±7 (SD) years (range: 47-78years). For each SSLN, type (pure ground-glass or part-solid) was assessed by consensus and CTTA was conducted independently by each observer using a filtration-histogram technique...
February 21, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29476118/disentangling-thermal-stress-responses-in-a-reef-calcifier-and-its-photosymbionts-by-shotgun-proteomics
#10
Marleen Stuhr, Bernhard Blank-Landeshammer, Claire E Reymond, Laxmikanth Kollipara, Albert Sickmann, Michal Kucera, Hildegard Westphal
The proliferation of key marine ecological engineers and carbonate producers often relies on their association with photosymbiotic algae. Evaluating stress responses of these organisms is important to predict their fate under future climate projections. Physiological approaches are limited in their ability to resolve the involved molecular mechanisms and attribute stress effects to the host or symbiont, while probing and partitioning of proteins cannot be applied in organisms where the host and symbiont are small and cannot be physically separated...
February 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29434453/faecal-calprotectin-and-magnetic-resonance-imaging-in-detecting-crohn-s-disease-endoscopic-postoperative-recurrence
#11
Pierre Baillet, Guillaume Cadiot, Marion Goutte, Felix Goutorbe, Hedia Brixi, Christine Hoeffel, Christophe Allimant, Maud Reymond, Hélène Obritin-Guilhen, Benoit Magnin, Gilles Bommelaer, Bruno Pereira, Constance Hordonneau, Anthony Buisson
AIM: To assess magnetic resonance imaging (MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease (CD). METHODS: From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo (5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29386647/structural-basis-of-the-molecular-ruler-mechanism-of-a-bacterial-glycosyltransferase
#12
Ana S Ramírez, Jérémy Boilevin, Ahmad Reza Mehdipour, Gerhard Hummer, Tamis Darbre, Jean-Louis Reymond, Kaspar P Locher
The membrane-associated, processive and retaining glycosyltransferase PglH from Campylobacter jejuni is part of the biosynthetic pathway of the lipid-linked oligosaccharide (LLO) that serves as the glycan donor in bacterial protein N-glycosylation. Using an unknown counting mechanism, PglH catalyzes the transfer of exactly three α1,4 N-acetylgalactosamine (GalNAc) units to the growing LLO precursor, GalNAc-α1,4-GalNAc-α1,3-Bac-α1-PP-undecaprenyl. Here, we present crystal structures of PglH in three distinct states, including a binary complex with UDP-GalNAc and two ternary complexes containing a chemo-enzymatically generated LLO analog and either UDP or synthetic, nonhydrolyzable UDP-CH2-GalNAc...
January 31, 2018: Nature Communications
https://www.readbyqxmd.com/read/29291349/an-opr3-independent-pathway-uses-4-5-didehydrojasmonate-for-jasmonate-synthesis
#13
Andrea Chini, Isabel Monte, Angel M Zamarreño, Mats Hamberg, Steve Lassueur, Philippe Reymond, Sally Weiss, Annick Stintzi, Andreas Schaller, Andrea Porzel, José M García-Mina, Roberto Solano
Biosynthesis of the phytohormone jasmonoyl-isoleucine (JA-Ile) requires reduction of the JA precursor 12-oxo-phytodienoic acid (OPDA) by OPDA reductase 3 (OPR3). Previous analyses of the opr3-1 Arabidopsis mutant suggested an OPDA signaling role independent of JA-Ile and its receptor COI1; however, this hypothesis has been challenged because opr3-1 is a conditional allele not completely impaired in JA-Ile biosynthesis. To clarify the role of OPR3 and OPDA in JA-independent defenses, we isolated and characterized a loss-of-function opr3-3 allele...
February 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29290337/kiaa1109-variants-are-associated-with-a-severe-disorder-of-brain-development-and-arthrogryposis
#14
Lucie Gueneau, Richard J Fish, Hanan E Shamseldin, Norine Voisin, Frédéric Tran Mau-Them, Egle Preiksaitiene, Glen R Monroe, Angeline Lai, Audrey Putoux, Fabienne Allias, Qamariya Ambusaidi, Laima Ambrozaityte, Loreta Cimbalistienė, Julien Delafontaine, Nicolas Guex, Mais Hashem, Wesam Kurdi, Saumya Shekhar Jamuar, Lim J Ying, Carine Bonnard, Tommaso Pippucci, Sylvain Pradervand, Bernd Roechert, Peter M van Hasselt, Michaël Wiederkehr, Caroline F Wright, Ioannis Xenarios, Gijs van Haaften, Charles Shaw-Smith, Erica M Schindewolf, Marguerite Neerman-Arbez, Damien Sanlaville, Gaëtan Lesca, Laurent Guibaud, Bruno Reversade, Jamel Chelly, Vaidutis Kučinskas, Fowzan S Alkuraya, Alexandre Reymond
Whole-exome and targeted sequencing of 13 individuals from 10 unrelated families with overlapping clinical manifestations identified loss-of-function and missense variants in KIAA1109 allowing delineation of an autosomal-recessive multi-system syndrome, which we suggest to name Alkuraya-Kučinskas syndrome (MIM 617822). Shared phenotypic features representing the cardinal characteristics of this syndrome combine brain atrophy with clubfoot and arthrogryposis. Affected individuals present with cerebral parenchymal underdevelopment, ranging from major cerebral parenchymal thinning with lissencephalic aspect to moderate parenchymal rarefaction, severe to mild ventriculomegaly, cerebellar hypoplasia with brainstem dysgenesis, and cardiac and ophthalmologic anomalies, such as microphthalmia and cataract...
January 4, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29237728/slightly-deleterious-genomic-variants-and-transcriptome-perturbations-in-down-syndrome-embryonic-selection
#15
Konstantin Popadin, Stephan Peischl, Marco Garieri, M Reza Sailani, Audrey Letourneau, Federico Santoni, Samuel W Lukowski, Georgii A Bazykin, Sergey Nikolaev, Diogo Meyer, Laurent Excoffier, Alexandre Reymond, Stylianos E Antonarakis
The majority of aneuploid fetuses are spontaneously miscarried. Nevertheless, some aneuploid individuals survive despite the strong genetic insult. Here, we investigate if the survival probability of aneuploid fetuses is affected by the genome-wide burden of slightly deleterious variants. We analyzed two cohorts of live-born Down syndrome individuals (388 genotyped samples and 16 fibroblast transcriptomes) and observed a deficit of slightly deleterious variants on Chromosome 21 and decreased transcriptome-wide variation in the expression level of highly constrained genes...
January 2018: Genome Research
https://www.readbyqxmd.com/read/29209081/low-number-of-fixed-somatic-mutations-in-a-long-lived-oak-tree
#16
Emanuel Schmid-Siegert, Namrata Sarkar, Christian Iseli, Sandra Calderon, Caroline Gouhier-Darimont, Jacqueline Chrast, Pietro Cattaneo, Frédéric Schütz, Laurent Farinelli, Marco Pagni, Michel Schneider, Jérémie Voumard, Michel Jaboyedoff, Christian Fankhauser, Christian S Hardtke, Laurent Keller, John R Pannell, Alexandre Reymond, Marc Robinson-Rechavi, Ioannis Xenarios, Philippe Reymond
Because plants do not possess a defined germline, deleterious somatic mutations can be passed to gametes, and a large number of cell divisions separating zygote from gamete formation may lead to many mutations in long-lived plants. We sequenced the genome of two terminal branches of a 234-year-old oak tree and found several fixed somatic single-nucleotide variants whose sequential appearance in the tree could be traced along nested sectors of younger branches. Our data suggest that stem cells of shoot meristems in trees are robustly protected from the accumulation of mutations...
December 2017: Nature Plants
https://www.readbyqxmd.com/read/29206041/lipidated-peptide-dendrimers-killing-multidrug-resistant-bacteria
#17
Thissa N Siriwardena, Michaela Stach, Runze He, Bee-Ha Gan, Sacha Javor, Marc Heitz, Lan Ma, Xiangju Cai, Peng Chen, Dengwen Wei, Hongtao Li, Jun Ma, Thilo Köhler, Christian van Delden, Tamis Darbre, Jean-Louis Reymond
New antibiotics are urgently needed to address multidrug-resistant (MDR) bacteria. Herein we report that second-generation (G2) peptide dendrimers bearing a fatty acid chain at the dendrimer core efficiently kill Gram-negative bacteria including Pseudomonas aeruginosa and Acinetobacter baumannii, two of the most problematic MDR bacteria worldwide. Our most active dendrimer TNS18 is also active against Gram-positive methicillin-resistant Staphylococcus aureus. Based on circular dichroism and molecular dynamics studies, we hypothesize that TNS18 adopts a hydrophobically collapsed conformation in water with the fatty acid chain backfolded onto the peptide dendrimer branches and that the dendrimer unfolds in contact with the membrane to expose its lipid chain and hydrophobic residues, thereby facilitating membrane disruption leading to rapid bacterial cell death...
January 10, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29195391/micro-view-cell-for-phase-behaviour-and-in-situ-raman-analysis-of-heterogeneously-catalysed-co-2-hydrogenation
#18
Helena Reymond, Philipp Rudolf von Rohr
The operando study of CO2 hydrogenation is fundamental for a more rational optimisation of heterogeneous catalyst and reactor designs. To further complement the established efficiency of microreactors in reaction screening and bridge the operating and optical gaps, a micro-view-cell is presented for Raman microscopy at extreme conditions with minimum flow interference for genuine reaction analysis. Based on a flat sapphire window unit sealed in a plug flow-type enclosure holding the sample, the cell features unique 14 mm working distance and 0...
November 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29193635/inactivation-of-ammecr1-is-associated-with-growth-bone-and-heart-alterations
#19
Mariana Moysés-Oliveira, Giuliana Giannuzzi, Richard J Fish, Jill A Rosenfeld, Florence Petit, Maria de Fatima Soares, Leslie Domenici Kulikowski, Adriana Di-Battista, Malú Zamariolli, Fan Xia, Thomas Liehr, Nadezda Kosyakova, Gianna Carvalheira, Michael Parker, Eleanor G Seaby, Sarah Ennis, Rodney D Gilbert, R Tanner Hagelstrom, Maria L Cremona, Wenhui L Li, Alka Malhotra, Anjana Chandrasekhar, Denise L Perry, Ryan J Taft, Julie McCarrier, Donald G Basel, Joris Andrieux, Taiza Stumpp, Fernanda Antunes, Gustavo José Pereira, Marguerite Neerman-Arbez, Vera Ayres Meloni, Margaret Drummond-Borg, Maria Isabel Melaragno, Alexandre Reymond
We report five individuals with loss-of-function of the X-linked AMMECR1: a girl with a balanced X-autosome translocation and inactivation of the normal X-chromosome; two boys with maternally inherited and de novo nonsense variants; and two half-brothers with maternally inherited microdeletion variants. They present with short stature, cardiac and skeletal abnormalities, and hearing loss. Variants of unknown significance in AMMECR1 in four male patients from two families with partially overlapping phenotypes were previously reported...
February 2018: Human Mutation
https://www.readbyqxmd.com/read/29186333/fun-a-framework-for-interactive-visualizations-of-large-high-dimensional-datasets-on-the-web
#20
Daniel Probst, Jean-Louis Reymond
Motivation: During the past decade, big data has become a major tool in scientific endeavors. While statistical methods and algorithms are well-suited for analyzing and summarizing enormous amounts of data, the results do not allow for a visual inspection of the entire data. Current scientific software, including R packages and Python libraries such as ggplot2, matplotlib, and plot.ly, do not support interactive visualizations of datasets exceeding 100,000 data points on the web. Other solutions enable the web-based visualization of big data only through data reduction or statistical representations...
November 24, 2017: Bioinformatics
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