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JOURNAL ARTICLE
Philippe Reymond, Evgenia Roussinova, Olivier Brina, Jeremy Hofmeister, Gianmarco Bernava, Andrea Rosi, William Galand, Karl-Olof Lovblad, Vitor M Pereira, Mohamed Bouri, Paolo Machi
BACKGROUND: The identification of specific clot characteristics before mechanical thrombectomy (MTB) might allow the selection of the most effective first-line technique, thus potentially improving the procedural outcome. We aimed to evaluate if the microwire push forces could extrapolate information on clot consistency and extension before MTB, based on clot mechanical properties. METHODS: We measured in vitro the forces exerted on the proximal extremity of the guidewire during the advancement and retrieval of the guidewire through clot analogs of different compositions...
April 18, 2024: Journal of Neurointerventional Surgery
#2
JOURNAL ARTICLE
Andrea Marco Amati, Stefan Urs Moning, Sacha Javor, Sandra Schär, Sabina Deutschmann, Jean-Louis Reymond, Christoph von Ballmoos
Adenosine triphosphate (ATP)-producing modules energized by light-driven proton pumps are powerful tools for the bottom-up assembly of artificial cell-like systems. However, the maximum efficiency of such modules is prohibited by the random orientation of the proton pumps during the reconstitution process into lipid-surrounded nanocontainers. Here, we overcome this limitation using a versatile approach to uniformly orient the light-driven proton pump proteorhodopsin (pR) in liposomes. pR is post-translationally either covalently or noncovalently coupled to a membrane-impermeable protein domain guiding orientation during insertion into preformed liposomes...
April 3, 2024: ACS Synthetic Biology
#3
JOURNAL ARTICLE
Deborah Parker, Liz Reymond, Karen Cooper, Jennifer Tieman, Serra Ivynian
OBJECTIVES: Most people say if they had a terminal illness, they would prefer to be cared for at home and, if possible, to die there. Often this is not possible without a carer to assist with on-going practical care and symptom management. If breakthrough symptoms are not treated in a timely manner, symptoms can escalate quickly causing increased suffering resulting in unwanted hospital transfers. Many carers report feeling motivated but uneducated for the task of medicine management, especially if it involves preparation and/or administration of subcutaneous medicines This study assesses the impact of an education and resource package, caring@home, on carers' confidence, knowledge, and skills in managing palliative symptoms at home using subcutaneous medicines...
January 8, 2024: BMJ Supportive & Palliative Care
#4
JOURNAL ARTICLE
Camilla Cerutti, Serena Lucotti, Sofia T Menendez, Nicolas Reymond, Ritu Garg, Ignacio A Romero, Ruth Muschel, Anne J Ridley
Attachment of circulating tumor cells to the endothelial cells (ECs) lining blood vessels is a critical step in cancer metastatic colonization, which leads to metastatic outgrowth. Breast and prostate cancers are common malignancies in women and men, respectively. Here, we observe that β1-integrin is required for human prostate and breast cancer cell adhesion to ECs under shear-stress conditions in vitro and to lung blood vessel ECs in vivo. We identify IQGAP1 and neural Wiskott-Aldrich syndrome protein (NWASP) as regulators of β1-integrin transcription and protein expression in prostate and breast cancer cells...
March 26, 2024: Cell Reports
#5
REVIEW
Double stent-retriever technique for mechanical thrombectomy: a systematic review and meta-analysis.
Jeremy Hofmeister, Olivier Brina, Gianmarco Bernava, Andrea Rosi, Philippe Reymond, Karl-Olof Lovblad, Paolo Machi
BACKGROUND: Mechanical thrombectomy using a double stent-retriever technique has recently been described for the treatment of acute ischemic stroke, but its efficacy and safety are not well established. PURPOSE: The aim of this systematic review and meta-analysis was to evaluate reports of the use of double stent-retriever during the endovascular treatment of patients with ischemic stroke. DATA SOURCES: The PubMed, Embase, Web of Science and Scopus databases were searched to identify all studies (clinical trials, cohorts series and case reports) investigating the utility of double stent-retriever for the treatment of stroke...
March 23, 2024: AJNR. American Journal of Neuroradiology
#6
JOURNAL ARTICLE
Mélanie Frei, Philippe Reymond, Julie Wacker, Mathieu Van Steenberghe, Maurice Beghetti, Tornike Sologashvili, Jean-Paul Vallée
OBJECTIVES: Many types of congenital heart disease are amenable to surgical repair or palliation. The procedures are often challenging and require specific surgical training, with limited real-life exposure and often costly simulation options. Our objective was to create realistic and affordable 3D simulation models of the heart and vessels to improve training. METHODS: We created molded vessel models using several materials, in order to identify the material that best replicated human vascular tissue...
March 5, 2024: European Journal of Cardio-thoracic Surgery
#7
JOURNAL ARTICLE
Olivier Jordan, Bee-Ha Gan, Sari Alwan, Karl Perron, Emmanuelle Sublet, Verena Ducret, Hua Ye, Gerrit Borchard, Jean-Louis Reymond, Viorica Patrulea
The burden of bacterial wound infections has considerably increased due to antibiotic resistance to most of the currently available antimicrobial drugs. Herein, we report for the first time a chemical coupling of two cationic N-aryl (pyridyl and aminocinnamyl) chitosan derivatives to antimicrobial peptide dendrimers (AMPDs) of different generations (first, second and third) via thioether-haloacetyl reaction. The new chitosan-AMPD conjugates showed high selectivity by killing Pseudomonas aeruginosa and very low toxicity towards mammalian cells, as well as extremely low hemolysis to red blood cells...
February 27, 2024: Advanced Healthcare Materials
#8
JOURNAL ARTICLE
Evangelos Balanikas, Maric Reymond-Joubin, Eric Vauthey
A large number of multipolar dyes undergo excited-state symmetry breaking (ESSB) in polar media. During this process, electronic excitation, initially distributed evenly over the molecule, localizes, at least partially, on one donor-acceptor branch. To resolve its initial stage, ESSB is investigated with a donor-acceptor-donor dye in binary mixtures of nonpolar and polar solvents using time-resolved infrared absorption spectroscopy. The presence of a few polar molecules around the dye is sufficient to initiate ESSB...
February 26, 2024: Journal of Physical Chemistry Letters
#9
Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles.
Sissy Bassani, Jacqueline Chrast, Giovanna Ambrosini, Norine Voisin, Frédéric Schütz, Alfredo Brusco, Fabio Sirchia, Lydia Turban, Susanna Schubert, Rami Abou Jamra, Jan-Ulrich Schlump, Desiree DeMille, Pinar Bayrak-Toydemir, Gary Rex Nelson, Kristen Nicole Wong, Laura Duncan, Mackenzie Mosera, Christian Gilissen, Lisenka E L M Vissers, Rolph Pfundt, Rogier Kersseboom, Hilde Yttervik, Geir Åsmund Myge Hansen, Marie Falkenberg Smeland, Kameryn M Butler, Michael J Lyons, Claudia M B Carvalho, Chaofan Zhang, James R Lupski, Lorraine Potocki, Leticia Flores-Gallegos, Rodrigo Morales-Toquero, Florence Petit, Binnaz Yalcin, Annabelle Tuttle, Houda Zghal Elloumi, Lane Mccormick, Mary Kukolich, Oliver Klaas, Judit Horvath, Marcello Scala, Michele Iacomino, Francesca Operto, Federico Zara, Karin Writzl, Ales Maver, Maria K Haanpää, Pia Pohjola, Harri Arikka, Christian Iseli, Nicolas Guex, Alexandre Reymond
BACKGROUND: We previously described the KINSSHIP syndrome, an autosomal dominant disorder associated with intellectual disability (ID), mesomelic dysplasia and horseshoe kidney,caused by de novo variants in the degron of AFF3. Mouse knock-ins and overexpression in zebrafish provided evidence for a dominant-negative (DN) mode-of-action, wherein an increased level of AFF3 resulted in pathological effects. METHODS: Evolutionary constraints suggest that other mode-of-inheritance could be at play...
January 17, 2024: medRxiv
#10
JOURNAL ARTICLE
Chiara Auwerx, Maarja Jõeloo, Marie C Sadler, Nicolò Tesio, Sven Ojavee, Charlie J Clark, Reedik Mägi, Alexandre Reymond, Zoltán Kutalik
BACKGROUND: Copy-number variations (CNVs) have been associated with rare and debilitating genomic disorders (GDs) but their impact on health later in life in the general population remains poorly described. METHODS: Assessing four modes of CNV action, we performed genome-wide association scans (GWASs) between the copy-number of CNV-proxy probes and 60 curated ICD-10 based clinical diagnoses in 331,522 unrelated white British UK Biobank (UKBB) participants with replication in the Estonian Biobank...
January 8, 2024: Genome Medicine
#11
JOURNAL ARTICLE
Gianmarco Bernava, Rosa Tesoro, José Boto, Myriam Challita, Andrea Rosi, Jeremy Hofmeister, Hasan Yilmaz, Emmanuel Carrera, Olivier Brina, Philippe Reymond, Michel Muster, Zsolt Kulcsar, Karl-Olof Lovblad, Paolo Machi
BACKGROUND: Focal vasospasm (FV) of the occluded vessel can occur during the endovascular treatment of acute ischemic stroke (AIS). Nimodipine is commonly used to treat vasospasm and can play a role in distinguishing it from artery narrowing due to iatrogenic dissection or residual clot. However, nimodipine administration can result in arterial hypotension and subsequent enlargement of the ischemic core. OBJECTIVE: To assess the efficacy of preventive and continuous vasoactive amine infusion to counterbalance nimodipine-induced hypotension...
December 17, 2023: Interventional Neuroradiology
#12
JOURNAL ARTICLE
Valentina Rossetti, Jean-Louis Reymond
In occasion of its conclusion, the National Center of Competence in Research (NCCR) TransCure launched a temporary learning and artistic path in the city of Bern named 'Vitaport - Was unser Körper transportiert'. The path explained how nutrients are transported through our body and how molecules find their way to the right organ to achieve their effect there. NCCR TransCure researchers, together with students of the Bern School of Design, developed ceramic objects, texts and information graphics that took the public on a multidisciplinary journey of discovery through the human body...
December 21, 2022: Chimia
#13
JOURNAL ARTICLE
Jean-Louis Reymond
Similar drug molecules often have similar properties and activities. Therefore, quantifying molecular similarity is central to drug discovery and optimization. Here I review computational methods using molecular similarity measures developed in my group within the interdisciplinary network NCCR TransCure investigating the physiology, structural biology and pharmacology of ion channels and membrane transporters. We designed a 3D molecular shape and pharmacophore comparison algorithm to optimize weak and unselective inhibitors by scaffold hopping and discovered potent and selective inhibitors of the ion channels TRPV6 and TRPM4, of endocannabinoid membrane transport, and of the divalent metal transporters DMT1 and ZIP8...
December 21, 2022: Chimia
#14
JOURNAL ARTICLE
Tin Manh Ho, Stephan Berger, Philipp Müller, Céline Simonin, Jean-Louis Reymond, Christoph Von Ballmoos, Daniel G Fuster
NHA2, also known as SLC9B2, is an orphan intracellular Na+/H+ exchanger (NHE) that has been associated with arterial hypertension and diabetes mellitus in humans. The objective of this NCCR TransCure project was to define the physiological and molecular function of NHA2, to develop a high resolution kinetic transport assay for NHA2 and to identify specific and potent compounds targeting NHA2. In this review, we summarize the results of this highly interdisciplinary and interfaculty effort, led by the groups of Proffs...
December 21, 2022: Chimia
#15
EDITORIAL
Hugues Abriel, Jean-Louis Reymond
No abstract text is available yet for this article.
December 21, 2022: Chimia
#16
JOURNAL ARTICLE
Etienne Bonvin, Hippolyte Personne, Thierry Paschoud, Jérémie Reusser, Bee-Ha Gan, Alexandre Luscher, Thilo Köhler, Christian van Delden, Jean-Louis Reymond
Among synthetic analogues of antimicrobial peptides (AMPs) under investigation to address antimicrobial resistance, peptoids ( N -alkylated oligoglycines) have been reported to act both by membrane disruption and on intracellular targets. Here we gradually introduced peptoid units into the membrane-disruptive undecapeptide KKLLKLLKLLL to test a possible transition toward intracellular targeting. We found that selected hybrids containing up to five peptoid units retained the parent AMP's α-helical folding, membrane disruption, and antimicrobial effects against Gram-negative bacteria including multidrug-resistant (MDR) strains of Pseudomonas aeruginosa and Klebsiella pneumoniae while showing reduced hemolysis and cell toxicities...
December 8, 2023: ACS Infectious Diseases
#17
JOURNAL ARTICLE
Huanjie Yang, Xeniya Kim, Jan Skłenar, Sébastien Aubourg, Gloria Sancho-Andrés, Elia Stahl, Marie-Charlotte Guillou, Nora Gigli-Bisceglia, Loup Tran Van Canh, Kyle W Bender, Annick Stintzi, Philippe Reymond, Clara Sánchez-Rodríguez, Christa Testerink, Jean-Pierre Renou, Frank L H Menke, Andreas Schaller, Jack Rhodes, Cyril Zipfel
Plant signalling peptides are typically released from larger precursors by proteolytic cleavage to regulate plant growth, development and stress responses. Recent studies reported the characterization of a divergent family of Brassicaceae-specific peptides, SERINE RICH ENDOGENOUS PEPTIDES (SCOOPs), and their perception by the leucine-rich repeat receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2). Here, we reveal that the SCOOP family is highly expanded, containing at least 50 members in the Columbia-0 reference Arabidopsis thaliana genome...
December 4, 2023: Nature Plants
#18
JOURNAL ARTICLE
Deborah Parker, Liz Reymond, Karen Cooper, Jennifer Tieman, Serra Ivynian
BACKGROUND: Most Australians say they wish to die at home, but many are admitted to inpatient facilities for symptom management. Caring@home resources can be used to support informal carers to manage breakthrough symptoms safely using subcutaneous medicines. Nurses require education about how to teach informal carers to use these resources. AIM: To evaluate the effectiveness and relevance of an online education programme for registered nurses (RNs) about using the caring@home resources...
November 2, 2023: International Journal of Palliative Nursing
#19
JOURNAL ARTICLE
Assia Daikh, Fabienne Reymond, Dorothée Lombardo, Caroline Thuillier, Pierrick Bedouch, Jean-Luc Faucheron
PURPOSE: Sacral nerve neuromodulation (SNM) is a safe and effective therapy for the management of fecal and/or urinary incontinence. The generators InterStim™ and InterStim™ II (Medtronic™) are non-rechargeable active implantable medical devices with a limited lifespan. The aims of this study were to assess the generators' median lifespan for all indications and the long-term hospital costs of the therapy. METHODS: This was a retrospective monocentric study that included 215 patients aged over 18 years who were treated by SNM for fecal incontinence and/or urinary incontinence...
November 28, 2023: International Journal of Colorectal Disease
#20
JOURNAL ARTICLE
Markus Orsi, Daniel Probst, Philippe Schwaller, Jean-Louis Reymond
Chemical space maps help visualize similarities within molecular sets. However, there are many different molecular similarity measures resulting in a confusing number of possible comparisons. To overcome this limitation, we exploit the fact that tools designed for reaction informatics also work for alchemical processes that do not obey Lavoisier's principle, such as the transmutation of lead into gold. We start by using the differential reaction fingerprint (DRFP) to create tree-maps (TMAPs) representing the chemical space of pairs of drugs selected as being similar according to various molecular fingerprints...
October 9, 2023: Digit Discov
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