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Retinoic Acid 0.05

J J Wen, Z B Liu, C G Xu
Objective: To determine the anti-tumor effects of 13-cis-retinoic acid (13cRA) combined with interferonα-2b (IFNα-2b) in mantle cell lymphoma (MCL) animal model. Methods: The animal model of MCL was established by introducing Jeko-1 cell line into severe combined immunodeficiency disease mice. The successfully tumor-developed mice were assigned to different groups treated with negative control group (solvents), 13cRA (high dose: 200mg/kg; middle dose: 100mg/kg; low dose: 50 mg/kg) alone, IFNα-2b alone or combination of different dose of 13cRA with IFNα-2b, and positive control group (bortezomib, rituximab, cyclophosphamide), respectively...
September 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Richard F Schlenk, Michael Lübbert, Axel Benner, Alexander Lamparter, Jürgen Krauter, Wolfgang Herr, Hans Martin, Helmut R Salih, Andrea Kündgen, Heinz-A Horst, Peter Brossart, Katharina Götze, David Nachbaur, Mohammed Wattad, Claus-Henning Köhne, Walter Fiedler, Martin Bentz, Gerald Wulf, Gerhard Held, Bernd Hertenstein, Hans Salwender, Verena I Gaidzik, Brigitte Schlegelberger, Daniela Weber, Konstanze Döhner, Arnold Ganser, Hartmut Döhner
The aim of this clinical trial was to evaluate the impact of all-trans retinoic acid (ATRA) in combination with chemotherapy and to assess the NPM1 status as biomarker for ATRA therapy in younger adult patients (18-60 years) with acute myeloid leukemia (AML). Patients were randomized for intensive chemotherapy with or without open-label ATRA (45 mg/m(2), days 6-8; 15 mg/m(2), days 9-21). Two cycles of induction therapy were followed by risk-adapted consolidation with high-dose cytarabine or allogeneic hematopoietic cell transplantation...
October 3, 2016: Annals of Hematology
Naomi I Maria, Eline C Steenwijk, Arne S IJpma, Cornelia G van Helden-Meeuwsen, Petra Vogelsang, Wouter Beumer, Zana Brkic, Paul L A van Daele, P Martin van Hagen, Peter J van der Spek, Hemmo A Drexhage, Marjan A Versnel
OBJECTIVE: The interferon (IFN) type I signature is present in over half of patients with primary Sjögren's syndrome (pSS) and associated with higher disease-activity and autoantibody presence. Plasmacytoid dendritic cells (pDCs) are considered as the main source of enhanced IFN type I expression. The objective of this study was to unravel the molecular pathways underlying IFN type I bioactivity in pDCs of patients with pSS. METHODS: Blood samples from 42 healthy controls (HC) and 115 patients with pSS were stratified according to their IFN type I signature...
September 26, 2016: Annals of the Rheumatic Diseases
Esrafil Mansouri, Ameneh Hardani, Mohamad Reza Afzalzadeh, Ashraf Amir Zargar, Zakiaeh Meamar
Retinoic acid and Rosa damascena are compounds that have considerable effects in the cellular proliferation and synthesis of extracellular matrix. The present study was designed to assess the combined effects of retinoic acid and Rosa damascena mill on wound in diabetic rats. Seventy-two rats were used in this study. Diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg. Kg(-1)). Then, a full thickness wound was created on dorsal surface of all animals. After that, rats were divided, into three groups; control (normal saline), positive control (Phenytoin), and  case (combined of 0...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Beata Nowak, Agnieszka Matuszewska, Jarosław Filipiak, Anna Nikodem, Anna Merwid-Ląd, Małgorzata Pieśniewska, Joanna Kwiatkowska, Bartosz Grotthus, Adam Szeląg
BACKGROUND: Drug-induced osteoporosis is a significant health problem, as many drugs have deleterious effects on bone metabolism. Data from several studies concerning the influence of retinol on bone homeostasis are inconsistent. OBJECTIVES: The purpose of this study was to investigate the influence of tazarotene, a selective agonist of the retinoic acid receptor (RAR), on bone metabolism and bone mechanical properties in rats. MATERIAL AND METHODS: Sixteen male Wistar rats were assigned either to the group receiving tazarotene or to the control group...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Fatemeh Sabbaghziarani, Keywan Mortezaee, Mohammad Akbari, Iraj Ragerdi Kashani, Mansooreh Soleimani, Ashraf Moini, Nahid Ataeinejad, Adib Zendedel, Gholamreza Hassanzadeh
Stroke is the consequence of limited blood flow to the brain with no established treatment to reduce the neurological deficits. Focusing on therapeutic protocols in targeting subventricular zone (SVZ) neurogenesis has been investigated recently. This study was designed to evaluate the effects of retinoic acid (RA)-pretreated Wharton's jelly mesenchymal stem cells (WJ-MSCs) in combination with triiodothyronine (T3) in the ischemia stroke model. Male Wistar rats were used to induce focal cerebral ischemia by middle cerebral artery occlusion (MCAO)...
August 22, 2016: Metabolic Brain Disease
Vikram Gota, Girish Chinnaswamy, Tushar Vora, Sanhita Rath, Akanksha Yadav, Murari Gurjar, Gareth Veal, Purna Kurkure
PURPOSE: To compare the pharmacokinetics of 13-cis retinoic acid (13-cisRA) between Indian and UK neuroblastoma patients receiving comparable treatment, alongside measures of toxicity and response. METHODS: 13-cisRA (160 mg/m(2)/day) was administered to 36 patients ≤16 years in two divided doses. Plasma 13-cisRA concentrations were determined on days 1 and 14 of cycles 1 and 4 of treatment. Area under the plasma concentration-time curve (AUC0-6h) was estimated using non-compartment modelling...
October 2016: Cancer Chemotherapy and Pharmacology
Shamsoulmolouk Najafi, Narges Gholizadeh, Elahe Akhavan Rezayat, Mohammad Javad Kharrazifard
OBJECTIVES: Geographic tongue or migratory glossitis is an inflammatory disorder with unknown etiology. Considering the accompanied burning pain, taste dysfunction, and lack of definite cure, it is important to treat this condition symptomatically. The objective of the current study was to compare the efficacy of a combination of 0.05% retinoic acid and 0.1% triamcinolone acetonide with that of triamcinolone acetonide alone for treatment of symptomatic geographic tongue. MATERIALS AND METHODS: This randomized controlled double-blind clinical trial was performed on 28 patients with symptomatic geographic tongue, who were referred to two dental clinics...
January 2016: Journal of Dentistry of Tehran University of Medical Sciences
Abhishek Jauhari, Tanisha Singh, Ankita Pandey, Parul Singh, Nishant Singh, Ankur Kumar Srivastava, Aditya Bhushan Pant, Devendra Parmar, Sanjay Yadav
MicroRNAs (miRNAs) are generated by endonuclease activity of Dicer, which also helps in loading of miRNAs to their target sequences. SH-SY5Y, a human neuroblastoma and a cellular model of neurodevelopment, consistently expresses genes related to neurodegenerative disorders at different biological levels (DNA, RNA, and proteins). Using SH-SY5Y cells, we have studied the role of Dicer and miRNAs in neuronal differentiation and explored involvement of P53, a master regulator of gene expression in differentiation-induced induction of miRNAs...
August 15, 2016: Molecular Neurobiology
Selda Yildirim, Mehmet Salih Gurel, Sule Gungor, Omur Tekeli, Dilek Canat
INTRODUCTION: Skin aging is a problem which negatively affects the psyche of the person, social relations, as well as work life and health and which compels the patients to find appropriate treatment methods. Numerous treatment methods have been developed in order to delay aging and to reduce the aging effects in addition to having a younger, healthier and more beautiful facial appearance. AIM: To compare the efficiency, cosmetic results and possible adverse effects of the peeling treatment with 25% trichloroacetic acid (TCA) and 0...
June 2016: Postȩpy Dermatologii i Alergologii
Hanqing Li, Haiwen Zhou, Xin Fu, Ran Xiao
Human embryonic stem cells (hESCs) can differentiate into all somatic lineages including stratified squamous epithelia. Thus, efficient methods are required to direct hESC differentiation to obtain a pure subpopulation for tissue engineering. The study aimed to assess the effects of retinoic acid (RA), bone morphogenetic protein-4 (BMP4), and ascorbic acid (AA) on the differentiation of hESCs into keratinocyte progenitors in vitro. The first media contained AA and BMP4; the second contained RA, AA, and BMP4; the third was commercial-defined keratinocyte serum-free medium, which was used to differentiate H9 hESCs (direct approach) or embryoid bodies (EBs) (indirect approach) into keratinocyte progenitors...
September 2016: In Vitro Cellular & Developmental Biology. Animal
Giovanni Lodi, Roberto Franchini, Saman Warnakulasuriya, Elena Maria Varoni, Andrea Sardella, Alexander R Kerr, Antonio Carrassi, L C I MacDonald, Helen V Worthington
BACKGROUND: Oral leukoplakia is a relatively common oral lesion that, in a small proportion of people, precedes the development of oral cancer. Most leukoplakias are asymptomatic; therefore, the primary objective of treatment should be to prevent onset of cancer. This review updates our previous review, published in 2006. OBJECTIVES: To assess the effectiveness, safety and acceptability of treatments for leukoplakia in preventing oral cancer. SEARCH METHODS: We searched the following electronic databases: Cochrane Oral Health's Trials Register (to 16 May 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2016, Issue 4), MEDLINE Ovid (1946 to 16 May 2016), Embase Ovid (1980 to 16 May 2016) and CancerLit via PubMed (1950 to 16 May 2016)...
2016: Cochrane Database of Systematic Reviews
Hyun-Suk Lee, Sun-Ouck Kim, Kyuyoun Ahn, Kwangsung Park
INTRODUCTION: Water channel aquaporin 3 (AQP3) is an aquaglyceroporin that transports small neutral solutes and water. All-trans retinoic acid (ATRA), a member of the retinoid drug class, acts as a regulator in several biological processes. AIM: To investigate the effect of ATRA on the expression of AQP3 in human vaginal epithelial cells. METHODS: Human vaginal mucosal epithelial cells (CRL2616) were treated with ATRA 0, 0.01, 0.1, and 1 μmol/L for 24 hours to examine the dose-dependent effects of ATRA and with ATRA 1 μmol/L for 0, 3, 6, 12, and 24 hours...
July 22, 2016: Sexual Medicine
Burcu Bakır, Zuhal Yetkin Ay, H İbrahim Büyükbayram, Duygu Kumbul Doğuç, Dilek Bayram, I Aydın Candan, Ersin Uskun
BACKGROUND: Curcumin has anti-inflammatory and antioxidant effects and is reported to have several biological activities. Hence, the current study examined the effect of curcumin on the systemic Th17 response, on the gingival expression of IL-17 and retinoic acid receptor-related orphan receptor (RORγt), and on alveolar bone loss (ABL) in experimental periodontitis. METHODS: Thirty-eight male albino Wistar rats were divided into four groups: Group 1: periodontitis; Group 2: periodontitis with curcumin treatment; Group 3: periodontally healthy with curcumin treatment; Group 4: periodontally healthy...
July 23, 2016: Journal of Periodontology
Yafang Ma, Lu Liu, Jie Jin, Yinjun Lou
BACKGROUND: Recently, the all-trans retinoic acid (ATRA) plus arsenic trioxide (ATO) protocol has become a promising first-line therapeutic approach in patients with newly diagnosed acute promyelocytic leukemia (APL), but its benefits compared with standard ATRA plus chemotherapy regimen needs to be proven. Herein, we conducted a meta-analysis comparing the efficacy of ATRA plus ATO with ATRA plus chemotherapy for adult patients with newly diagnosed APL. METHODS: We systematically searched biomedical electronic databases and conference proceedings through February 2016...
2016: PloS One
Ran Li, Yanhong Tan, Xiuhua Chen, Fanggang Ren, Yaofang Zhang, Hongwei Wang
BACKGROUND: Current diagnostic methods of acute promyelocytic leukemia (APL) have some inevitable shortcomings; therefore, further studies are needed to develop more effective diagnostic methods. We used functionalized graphene oxide (GO) to detect the promyelocytic leukemia/retinoic acid receptor, α fusion gene (PML/RARα fusion gene) in bone marrow of APL patients. This method was more convenient and time-saving, and we can obtain the detection results in 1 hour. METHODS: Our group consists of 36 cases, among them are 16 cases which are PML-RARα positive, 20 cases which are PML-RARα negative...
2016: Clinical Laboratory
Xiao-Li Huang, Xin Zhang, Xian-Yan Fei, Zhao-Gui Chen, Yan-Ping Hao, Shu Zhang, Ming-Ming Zhang, Yan-Qiu Yu, Cheng-Gong Yu
AIM: To explore the preventive and therapeutic effects of Faecalibacterium prausnitzii (F. prausnitzii) supernatant on dextran sulfate sodium (DSS) induced colitis in mice. METHODS: Forty C57BL/6J male mice were randomly divided into four groups: control group, model group, treatment group, and prevention group. Mice were weighed daily. On day 10, the colon length was measured, the colorectal histopathologic damage score (HDS) was assessed, and plasma interleukin (IL)-17A, IL-6, and IL-4 levels were detected by enzyme-linked immunosorbent assay...
June 14, 2016: World Journal of Gastroenterology: WJG
Jianbin Zhao, Jie Ma, Xiaoyan Zhang, Qing Li, Xueping Yang
The aim of the present study was to examine changes of cellular homeostasis in regulatory T (Treg) and T helper 17 (Th17) cells by detecting the proportion of Treg and Th17 cells of peripheral blood, as well as the expression of specific transcription factors in these two types of cells, in syphilitic patients with sero-resistance. A total of 49 subjects were enrolled in the study and divided into two groups, comprising 26 cases of sero-resistant syphilitic patients in the experimental group, and 23 cases of healthy donors in the normal control group...
June 2016: Experimental and Therapeutic Medicine
Sadudee Chotirat, Tawit Suriyo, Marianne Hokland, Peter Hokland, Jutamaad Satayavivad, Chirayu U Auewarakul
The non-neuronal cholinergic system (NNCS) has been shown to play a role in regulating hematopoietic differentiation. We determined the expression of cholinergic components in leukemic cell lines by Western blotting and in normal leukocyte subsets by flow cytometry and found a heterogeneous expression of choline acetyltransferase (ChAT), acetylcholinesterase (AChE), choline transporter (CHT), M3 muscarinic acetylcholine receptor (M3-mAChR) and α7 nicotinic acetylcholine receptor (α7-nAChR). We then evaluated NNCS role in differentiation of human NB-4 acute promyelocytic leukemia cell line and discovered a dramatic induction of M3-mAChR after all-trans retinoic acid (ATRA) treatment (p<0...
July 2016: Blood Cells, Molecules & Diseases
Luis A Videla, Virginia Fernández, Romina Vargas, Pamela Cornejo, Gladys Tapia, Nelson Varela, Rodrigo Valenzuela, Allan Arenas, Javier Fernández, María C Hernández-Rodas, Bárbara Riquelme
Prevention of ischemia-reperfusion liver injury is achieved by a combined omega-3 and thyroid hormone (T3 ) protocol, which may involve peroxisome-proliferator activated receptor-α (PPAR-α)-fibroblast growth factor 21 (FGF21) signaling supporting energy requirements. Combined docosahexaenoic acid (DHA; daily doses of 300 mg/kg for 3 days) plus 0.05 mg T3 /kg given to fed rats elicited higher hepatic DHA contents and serum T3 levels, increased PPAR-α mRNA and its DNA binding, with higher mRNA expression of the PPAR-α target genes for carnitine-palmitoyl transferase 1α, acyl-CoA oxidase, and 3-hydroxyl-3-methylglutaryl-CoA synthase 2, effects that were mimicked by 0...
June 1, 2016: BioFactors
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