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https://www.readbyqxmd.com/read/28097379/t1-bright-appendix-sign-to-exclude-acute-appendicitis-in-pregnant-women
#1
Ilah Shin, Chansik An, Joon Seok Lim, Myeong-Jin Kim, Yong Eun Chung
OBJECTIVE: To evaluate the diagnostic value of the T1 bright appendix sign for the diagnosis of acute appendicitis in pregnant women. MATERIAL AND METHODS: This retrospective study included 125 pregnant women with suspected appendicitis who underwent magnetic resonance (MR) imaging. The T1 bright appendix sign was defined as a high intensity signal filling more than half length of the appendix on T1-weighted imaging. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the T1 bright appendix sign for normal appendix identification were calculated in all patients and in those with borderline-sized appendices (6-7 mm)...
January 17, 2017: European Radiology
https://www.readbyqxmd.com/read/28096326/a-rare-presentation-of-an-acute-appendicitis
#2
Ali Kordzadeh, Bruno Lorenzi, Jiten P Kalyan, Muhammad A Hanif, Alexandros Charalabopoulos
Paraumbilical hernia sac usually contains omentum, bowel loop and rarely appendicular epiploicae, metastatic deposits and vermiform appendix. Presentation of acute appendicitis in a paraumbilical hernia is rare and limited to few case reports in the literature. Herein, we would like to report a case of a successfully treated acute appendicitis presenting in a paraumbilical hernia in an 84-year-old lady with 6-month follow-up.
January 17, 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28094884/oxygen-delivery-as-a-limiting-factor-in-modelling-dicopper-ii-oxidase-reactivity
#3
Jana Gülzow, Gerald Hoerner, Peter Strauch, Anika Stritt, Elisabeth Irran, Andreas Grohmann
Ionisation of ligand-appended alkoxyl groups in mononuclear copper(II) complexes of N,O ligands L1 and L2, results in dinuclear complexes sharing symmetrical Cu2O2 cores. Mono- and binuclear complexes thus derived have been characterised with respect to molecular structure (XRD), electronic structure (UV-Vis, 1H-NMR, and EPR; density functional methods) and catalytic performance as models of catechol oxidase. The binuclear complexes with anti-ferromagnetically coupled copper(II) centres are moderately active in quinone formation from 3,5-di-tert-butyl-catechol under the established conditions of oxygen saturation, but are strongly activated when additional dioxygen is administered during catalytic turnover...
January 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28094476/dna-encoded-compound-libraries-as-open-source-a%C3%A2-powerful-pathway-to-new-drugs
#4
EDITORIAL
Richard A Lerner, Sydney Brenner
"… We envisioned an iterative system where a unique DNA tag identifier that encoded the event was appended to each newly formed molecule. These vast collections of molecules are known today as DNA- encoded chemical libraries (DECLs), and allow scientists to do selections on the benchtop that previously required access to large and complex high-throughput screening centers …" Read more in the Guest Editorial by Richard A. Lerner and Sydney Brenner.
January 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28094356/morphology-transition-in-helical-tubules-of-a-supramolecular-gel-driven-by-metal-ions
#5
Krishnamoorthy Lalitha, Vellaisamy Sridharan, C Uma Maheswari, Praveen Kumar Vemula, Subbiah Nagarajan
Our aim to access a particular chemical functionality on helical tubules has been achieved by the rational molecular design and synthesis of glucono-appended cardanol derivatives. For the first time, we report a chiral molecular packing with α-helical tubules, and chiral symmetry-breaking upon exposure to Cu(2+) that generated the final ordered structure via an in situ morphological transition without undergoing any phase change.
January 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28092251/-acute-appendicitis-surgical-and-non-surgical-treatment
#6
Luis Manuel Souza-Gallardo, José Luis Martínez-Ordaz
Appendicitis represents a common disease for the surgeon with a relative risk between 7-8%. It was thought that if more time passed between diagnosis and treatment, the risk for complications, such as perforation or abscess formation, was higher; nevertheless; the evolution is variable, making necessary the development of different strategies such as antibiotic use only, interval surgery or endoscopic treatment. The purpose of this study is to make a revision in the management of appendicitis comparing conservative and surgical treatment...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28091700/computed-tomography-localization-of-the-appendix-in-the-pediatric-population-relative-to-the-lumbar-spine
#7
John Davis, Albert T Roh, Matthew B Petterson, Tammy R Kopelman, Samantha L Matz, Daniel G Gridley, Mary J Connell
BACKGROUND: Computed tomography (CT) is commonly used to evaluate suspected acute appendicitis. Although very effective, CT uses ionizing radiation, exposing patients to an increased risk of cancer. OBJECTIVE: This study assessed the potential for decreasing the field of view of the CT (and therefore the dose to the patient) in the evaluation of suspected acute appendicitis in children. MATERIALS AND METHODS: This study was a retrospective review of prospectively collected data from 212 consecutive patients who underwent CT for suspected acute appendicitis...
January 14, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28089500/c-reactive-protein-may-predict-the-recurrence-of-appendicitis-in-children-formerly-with-appendiceal-mass-after-successful-non-operative-treatment
#8
Yi-Jung Chang, Hsun-Chin Chao, Chyi-Liang Chen, Shin-Yann Chen, Dah-Chin Yan, Ming-Han Tsai
BACKGROUND: This study identified factors associated with the recurrence of appendicitis in children with appendiceal masses after successful nonsurgical treatment. METHODS: In this retrospective study, children who were diagnosed as having appendiceal masses after undergoing conservative treatment between 2000 and 2014 were enrolled and the medical records of those who did not undergo an interval appendectomy were reviewed. The clinical features and outcomes of patients with and those without recurrent appendicitis were compared...
December 15, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28088862/self-assembling-peptides-epitopes-as-a-novel-platform-for-anti-cancer-vaccination
#9
Mazda Rad-Malekshahi, Marieke F Fransen, Małgorzata Krawczyk, Mercedeh Mansourian, Meriem Bourajjaj, Jian Chen, Ferry Ossendorp, Wim E Hennink, Enrico Mastrobattista, Maryam Amidi
The aim of the present study was to improve the immunogenicity of peptide epitope vaccines using novel nanocarriers based on self-assembling materials. Several studies demonstrated that peptide antigens in nanoparticulate forms induce stronger immune response than their soluble forms. However, several issues such as poor loading and risk of inducing T cell anergy due to premature release of antigenic epitopes have challenged the clinical success of such systems. In the present study, we developed two vaccine delivery systems by appending a self-assembling peptide (Ac-AAVVLLLW-COOH) or a thermosensitive polymer poly(N-isopropylacrylamide (pNIPAm) to the N-terminus of different peptide antigens (OVA250-264, HPV-E743-57) to generate self-assembling peptide epitopes (SAPEs)...
January 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28081559/an-unusual-cause-of-acute-appendicitis-in-new-zealand
#10
Yee Chen Lau
No abstract text is available yet for this article.
January 13, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28078461/cost-effectiveness-of-prophylactic-appendectomy-a-markov-model
#11
Karina Newhall, Benjamin Albright, Anna Tosteson, Elissa Ozanne, Thadeus Trus, Philip P Goodney
BACKGROUND: Appendectomy is the most common emergency surgery performed in the USA. Removal of a non-inflamed appendix during unrelated abdominal surgery (prophylactic or incidental appendectomy) can prevent the downstream risks and costs of appendicitis. It is unknown whether such a strategy could be cost saving for the health system. METHODS: We considered hypothetical patient cohorts of varying ages from 18 to 80, undergoing elective laparoscopic abdominal and pelvic procedures...
January 11, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28074461/acute-appendicitis-during-pregnancy-case-series-of-20-pregnant-women
#12
İlker Murat Arer, Songül Alemdaroğlu, Hasan Yeşilağaç, Hakan Yabanoğlu
BACKGROUND: Acute appendicitis (AA) is the most common cause of acute abdomen during pregnancy. Most of the signs of appendicitis are also found during normal pregnancy period, however, and diagnosis of appendicitis during pregnancy remains challenging. The aim of the current study was to report our clinical experience of AA during pregnancy and investigate optimal management of this difficult situation. METHODS: Records of 20 pregnant women with diagnosis of AA who underwent appendectomy between 2005 and 2015 were included in this study...
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28074455/effect-of-medical-treatment-on-histological-findings-in-rabbits-with-acute-appendicitis
#13
Gürcan Şimşek, Barış Sevinç, Yaşar Ünlü, İsmail Hasırcı, Hüseyin Kurku, Ömer Karahan
BACKGROUND: Acute appendicitis (AA) is the most common reason for abdominal surgery in the world. The aim of this study was to evaluate the effect of medical treatment on histological findings in rabbits with AA. METHODS: Twenty-one male New Zealand rabbits were divided into 3 groups: appendix ligation and medical treatment, appendix ligation and no treatment, and control group, which underwent only laparotomy. RESULTS: In appendix ligation without treatment group, AA findings were much more severe...
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28074452/hemoptysis-caused-by-pulmonary-sequestration-in-perforated-appendicitis-a-rare-case-report
#14
Dario Tartaglia, Francesca Cascione, Matteo Modesti, Desiree Gianardi, Rosilde Caputo, Christian Galatioto, Massimo Chiarugi
Pulmonary sequestration is a rare and usually asymptomatic congenital anomaly. Optimal management of this condition is still a subject of debate, including superiority of surgical resection or angiographic embolization of the aberrant arterial vessel. Presently described is rare case of a 51-year-old male who presented with hemoptysis related to pulmonary sequestration associated with acute right lower quadrant abdominal pain caused by perforated appendicitis.
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28074278/laparoscopic-appendectomy-risk-factors-for-postoperative-intraabdominal-abscess
#15
Francisco Schlottmann, Emmanuel E Sadava, M E Peña, Nicolás A Rotholtz
BACKGROUND: Laparoscopic appendectomy (LA) has obtained wide acceptance over the last two decades. However, some studies suggest that there is an increased rate of intraabdominal abscess (IAA) when is compared with open appendectomy. Since postoperative IAA is associated with high morbidity, identifying predictive factors of this complication may help to prevent it. The aim of this study was to identify preoperative and intraoperative risk factors for IAA after LA. METHODS: From January 2005 to June 2015, all charts of consecutive patients underwent to LA were revised...
January 10, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28073700/the-yeast-ste2p-g-protein-coupled-receptor-dimerizes-on-the-cell-plasma-membrane
#16
Orkun Cevheroğlu, Gözde Kumaş, Melinda Hauser, Jeffrey M Becker, Çağdaş D Son
Dimerization of G protein-coupled receptors (GPCR) may play an important role in maturation, internalization, signaling and/or pharmacology of these receptors. However, the location where dimerization occurs is still under debate. In our study, variants of Ste2p, a yeast mating pheromone GPCR, were tagged with split EGFP (enhanced green fluorescent protein) fragments inserted between transmembrane domain seven and the C-terminus or appended to the C-terminus. Bimolecular Fluorescence Complementation (BiFC) assay was used to determine where receptor dimerization occurred during protein trafficking by monitoring generation of EGFP fluorescence, which occurred upon GPCR dimerization...
January 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28072446/randomized-clinical-trial-of-preoperative-dexamethasone-on-postoperative-nausea-and-vomiting-after-laparoscopy-for-suspected-appendicitis
#17
J Kleif, A Kirkegaard, J Vilandt, I Gögenur
BACKGROUND: Few studies have investigated the effects of preoperative dexamethasone in acute surgical patients. This study examined the effects of 8 mg dexamethasone administered intravenously 30 min before surgery for suspected acute appendicitis. METHODS: A multicentre, parallel-group, double-blind, placebo-controlled study was conducted at two university hospitals in Denmark. Adults undergoing laparoscopic surgery for suspected appendicitis were eligible for inclusion...
January 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28071890/peptide-conjugates-of-benzene-carboxylic-acids-as-agonists-and-antagonists-of-amylin-aggregation
#18
Ruel Z B Desamero, Adam A Profit, Jayson Del Rosario Vedad
Human islet amyloid polypeptide (hIAPP), also known as amylin, is a 37 residue peptide hormone that is stored and co-secreted with insulin. hIAPP plays a pivotal role in type 2 diabetes and is the major component of amyloid deposits found in the pancreas of patients afflicted with the disease. The self-assembly of hIAPP and the formation of amyloid is linked to the death of insulin producing -cells. Recent findings suggest soluble hIAPP oligomers are the cytotoxic species responsible for -cell loss whereas amyloid fibrils themselves may indeed be innocuous...
January 10, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28064243/meckel-s-diverticulitis-a-rare-entity-of-meckel-s-diverticulum
#19
Chee S Wong, Leanne Dupley, Haren N Varia, Darek Golka, Thu Linn
Meckel's diverticulum is the most common congenital abnormality of the small intestine that results from incomplete closure of the vitelline (omphalo-mesenteric) duct. This true diverticulum, ~2 ft from the ileocecal valve commonly found on the anti-mesenteric border of the ileum, is benign and majority asymptomatic. Diagnosis challenges arise when it became inflamed or presented in following ways, for example, haemorrhage (caused by ectopic pepsin-and hydrochloric acid-secreting gastric mucosa), intestinal obstruction (secondary to intussusception or volvulus) or the presence of diverticulum in the hernia sac (Littre's hernia)...
January 6, 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28063718/second-date-appendectomy-operating-for-failure-of-nonoperative-treatment-in-perforated-appendicitis
#20
Marco Lotti
BACKGROUND: Nonoperative treatment of acute appendicitis is embraced by many surgical teams, driven by low to moderate quality randomized studies that support noninferiority of antibiotics versus appendectomy for treatment of acute uncomplicated appendicitis. Several flaws of these studies have emerged, especially in the recruitment strategy and in the diagnostic criteria that were used. The growing confidence given to antibiotics, together with the lack of reliable criteria to distinguish between uncomplicated and perforated appendicitis, exposes patients with perforated appendicitis to the likelihood to be treated with antibiotics instead of surgery...
January 2, 2017: American Journal of Emergency Medicine
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