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https://www.readbyqxmd.com/read/29148199/five-lessons-in-uncomplicated-appendicitis-can-we-remove-the-surgery
#1
Andrew Read, Jane Xu, Susan Adams, Jonathan Karpelowsky
Appendicectomy has remained the treatment of choice for appendicitis for over a century and is the most commonly performed emergency operation in children. However, emerging evidence suggests that appendicectomy may not always be necessary in uncomplicated appendicitis, with early paediatric trials demonstrating that antibiotic-only therapy can be safe and effective. Further rigorously designed and appropriately powered studies are necessarily to establish the place of non-operative management of uncomplicated appendicitis in the future...
November 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29146647/initial-non-operative-management-of-uncomplicated-appendicitis-in-children-a-protocol-for-a-multicentre-randomised-controlled-trial-apac-trial
#2
Max Knaapen, Johanna H van der Lee, Roel Bakx, Sarah-May L The, Ernst W E van Heurn, Hugo A Heij, Ramon R Gorter
INTRODUCTION: Based on epidemiological, immunological and pathology data, the idea that appendicitis is not necessarily a progressive disease is gaining ground. Two types are distinguished: simple and complicated appendicitis. Non-operative treatment (NOT) of children with simple appendicitis has been investigated in several small studies. So far, it is deemed safe. However, its effectiveness and effect on quality of life (QoL) have yet to be established in an adequately powered randomised trial...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146633/comparison-of-outcomes-of-antibiotic-drugs-and-appendectomy-coda-trial-a-protocol-for-the-pragmatic-randomised-study-of-appendicitis-treatment
#3
Giana H Davidson, David R Flum, David A Talan, Larry G Kessler, Danielle C Lavallee, Bonnie J Bizzell, Farhood Farjah, Skye D Stewart, Anusha Krishnadasan, Erin E Carney, Erika M Wolff, Bryan A Comstock, Sarah E Monsell, Patrick J Heagerty, Annie P Ehlers, Daniel A DeUgarte, Amy H Kaji, Heather L Evans, Julianna T Yu, Katherine A Mandell, Ian C Doten, Kevin S Clive, Karen M McGrane, Brandon C Tudor, Careen S Foster, Darin J Saltzman, Richard C Thirlby, Erin O Lange, Amber K Sabbatini, Gregory J Moran
INTRODUCTION: Several European studies suggest that some patients with appendicitis can be treated safely with antibiotics. A portion of patients eventually undergo appendectomy within a year, with 10%-15% failing to respond in the initial period and a similar additional proportion with suspected recurrent episodes requiring appendectomy. Nearly all patients with appendicitis in the USA are still treated with surgery. A rigorous comparative effectiveness trial in the USA that is sufficiently large and pragmatic to incorporate usual variations in care and measures the patient experience is needed to determine whether antibiotics are as good as appendectomy...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146455/successful-nonoperative-management-of-uncomplicated-appendicitis-predictors-and-outcomes
#4
Tyler J Loftus, Scott C Brakenridge, Chasen A Croft, R Stephen Smith, Philip A Efron, Frederick A Moore, Alicia M Mohr, Janeen R Jordan
BACKGROUND: Our objective was to identify predictors of successful nonoperative management (NOM) of uncomplicated appendicitis. We hypothesized that the absence of diabetes, absence of an appendicolith, short duration of symptoms, absence of systemic inflammation, and low modified Alvarado score would predict successful NOM. METHODS: We performed a retrospective cohort analysis of 81 consecutive patients who underwent NOM of uncomplicated appendicitis. Successful NOM was defined as resolution of appendicitis with antibiotics alone and no recurrent appendicitis within 180 days...
November 13, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29146070/acute-appendicitis-due-to-parasitosis
#5
Cristina Alejandre Villalobos, David Fernández-SanMillán, Eudaldo López-Tomassetti Fernández, Juan Ramón Hernández Hernández
No abstract text is available yet for this article.
November 13, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29145325/perforated-appendicitis-after-colonoscopy-cause-or-coincidence-a-rare-case-report-and-literature-review
#6
Xiao-Cong Zhou, Chun-Wei Huang, Yan-Yan Dai, Zhi-Yang Huang, Zheng Lou
RATIONALE: Colonoscopy is a relatively safe and common procedure with low risks of complications, and acute appendicitis with perforation is an extremely rare complication of colonoscopy. The current study presents an unusual case of acute gangrenous appendicitis with perforation following a screening colonoscopy. PATIENT CONCERNS: A 73-year-old man presented to our emergency department with lower right abdominal pain 3 days after a routine screening colonoscopy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143222/quantitative-analysis-of-the-level-of-readability-of-online-emergency-radiology-based-patient-education-resources
#7
David R Hansberry, Michael D'Angelo, Michael D White, Arpan V Prabhu, Mougnyan Cox, Nitin Agarwal, Sandeep Deshmukh
PURPOSE: The vast amount of information found on the internet, combined with its accessibility, makes it a widely utilized resource for Americans to find information pertaining to medical information. The field of radiology is no exception. In this paper, we assess the readability level of websites pertaining specifically to emergency radiology. METHODS: Using Google, 23 terms were searched, and the top 10 results were recorded. Each link was evaluated for its readability level using a set of ten reputable readability scales...
November 15, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29143092/laparoscopic-appendectomy-minimally-invasive-surgery-training-improves-outcomes-in-basic-laparoscopic-procedures
#8
Katherine D Gray, Joshua G Burshtein, Lama Obeid, Maureen D Moore, Gregory Dakin, Alfons Pomp, Cheguevara Afaneh
BACKGROUND: To determine whether minimally invasive surgery (MIS) training improves outcomes in laparoscopic appendectomy, a procedure that is commonly performed in general surgery training. METHODS: Retrospective review was conducted of all patients undergoing laparoscopic appendectomy for suspected acute appendicitis between 2014 and 2015 at a single-center, tertiary-care academic institution. Patients operated on by MIS-trained surgeons (MIS group) were compared to those operated on by general surgeons (GS group)...
November 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29141286/ultrasound-features-of-secondary-appendicitis-in-pediatric-patients
#9
Lyo Min Kwon, Kwanseop Lee, Soo Kee Min, Soo Min Ahn, Hong Il Ha, Min-Jeong Kim
Purpose: The purpose of this study was to evaluate the ultrasonographic findings of secondary appendicitis (SA) and to discuss the differential findings compared with primary appendicitis. Methods: In this study, we analyzed the ultrasonographic findings of 94 patients under 15 years old of age treated at our institution from May 2005 to May 2014 who had bowel inflammation and an inflamed appendix with a maximal outer diameter >6 mm that improved with nonsurgical treatment (the SA group)...
August 25, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29138382/-a-case-of-retroperitoneal-abscess-due-to-acute-appendicitis-during-neo-adjuvant-chemotherapy-for-breast-cancer
#10
Takaaki Oba, Kazuma Maeno, Kenichi Ito, Satoshi Ishizone, Takaomi Hanaoka
When acute appendicitis occurs in patients treated with chemotherapy, neutropenia and abdominal complaints caused by chemotherapy can contribute to the diagnostic difficulty, masking the increase in white blood cell(WBC)counts and physical findings of acute appendicitis. A 43-year-old premenopausal woman who was diagnosed with stage IIIA left breast cancer was scheduled for neoadjuvant chemotherapy includingfluorouracil plus epirubicin plus cyclophosphamide(FEC), followed by docetaxel and trastuzumab(DOC plus HER)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29137008/the-sonographic-features-of-neonatal-appendicitis-a-case-report
#11
Shu-Yu Si, Yi-Yi Guo, Jian-Feng Mu, Chao-Ying Yan
RATIONALE: Neonatal appendicitis is extremely rare, and preoperative diagnosis is challenging. This study aimed to investigate the utility of ultrasound for the diagnosis of neonatal appendicitis. PATIENT CONCERNS: Four cases of neonatal appendicitis were included in this case series. One was a female infant and the other 3 were male infants; they were aged from 10 to 17 days. DIAGNOSES: Neonatal appendicitis. INTERVENTIONS: Four newborns in our hospital were diagnosed with neonatal appendicitis by abdominal ultrasound...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135899/new-oxidative-stress-markers-useful-in-the-diagnosis-of-acute-appendicitis-in-children-thiol-disulfide-homeostasis-and-the-asymmetric-dimethylarginine-level
#12
Bahri Elmas, Turan Yildiz, Hayrullah Yazar, Zekeriya İlçe, Ceylan Bal, Betül Özbek, Yusuf Yürümez
OBJECTIVES: The aim of this study was to evaluate 2 new oxidative stress markers, thiol/disulfide homeostasis status and the asymmetric dimethylarginine (ADMA) level, in children with acute appendicitis (AA) and to evaluate their diagnostic utility. METHODS: This case-control study included 45 patients with AA and 35 healthy children. Age, sex, white blood cell count, neutrophil-to-lymphocyte ratio, high-sensitivity C-reactive protein (hs-CRP) level, ultrasonographic findings, thiol/disulfide homeostasis parameters (native and total thiol levels, native thiol/total thiol ratios [antioxidant parameters], and disulfide, disulfide/native thiol, and disulfide/total thiol ratios [oxidant parameters]), and the ADMA level were compared between the 2 groups...
November 14, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29134955/is-ultrasound-a-reliable-diagnostic-tool-for-acute-appendicitis-a-single-centre-experience
#13
Dimitrios Zosimas, Panagis M Lykoudis, Phoebe Leung, Giuseppe Strano, Veeranna Shatkar
AIM: Aim of the present study is to evaluate the utility of US as a diagnostic method for acute appendicitis (AA) in a district general hospital, by use of accurate quality indices. MATERIAL AND METHODS: The records of all patients who underwent an appendicectomy in a one year period in a single centre were reviewed. The patients who underwent a preoperative US scan were included in the study in accordance to specific criteria and the results were statistically compared to the final surgical histology...
November 14, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29134308/appendicitis-rural-patient-status-is-associated-with-increased-duration-of-prehospital-symptoms-and-worse-outcomes-in-high-and-low-middle-income-countries
#14
Matthew C Hernandez, Eric Finnesgaard, Johnathon M Aho, Victor Y Kong, John L Bruce, Stephanie F Polites, Grant L Laing, Damian L Clarke, Martin D Zielinski
INTRODUCTION: Appendicitis is a significant economic and healthcare burden in low-, middle-, and high-income countries. We aimed to determine whether urban and rural patient status would affect outcomes in appendicitis in a combined population regardless of country of economic status. We hypothesize that patients from rural areas and both high- and low-middle-income countries would have disproportionate outcomes and duration of symptoms compared to their urban counterparts. METHODS: Adults (≥18 years) with appendicitis during 2010-2016 in South Africa and USA were reviewed using multi-institutional data...
November 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29131879/time-to-appendectomy-and-risk-of-complicated-appendicitis-and-adverse-outcomes-in-children-reply
#15
Shawn J Rangel
No abstract text is available yet for this article.
November 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29131877/time-to-appendectomy-and-risk-of-complicated-appendicitis-and-adverse-outcomes-in-children
#16
William Bonadio
No abstract text is available yet for this article.
November 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29131764/nongynecologic-findings-seen-at-pelvic-us
#17
Akram M Shaaban, Maryam Rezvani, Jeffrey D Olpin, Anne M Kennedy, Ayman H Gaballah, Bryan R Foster, Christine O Menias, Khaled M Elsayes
Ultrasonography (US) is frequently the first imaging modality used to examine women with symptoms involving the pelvis. It is widely available and involves no exposure to ionizing radiation. Images can be acquired with a transabdominal, endovaginal, or translabial approach, and the use of video clips and three-dimensional reconstructions can be helpful. US is excellent for assessment of the uterus, ovaries, and adnexa. Occasionally, nongynecologic pelvic diseases arising from the gastrointestinal, genitourinary, and musculoskeletal systems and the pelvic peritoneal and extraperitoneal spaces may be detected and can be a source of diagnostic dilemma...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29130739/trans-umbilical-laparoscopic-assisted-appendectomy-in-the-pediatric-population-comparing-single-incision-and-2-trocar-techniques
#18
Mariana Borges-Dias, Leonor Carmo, Ruben Lamas-Pinheiro, Tiago Henriques-Coelho, José Estevão-Costa
INTRODUCTION: Trans-umbilical laparoscopic-assisted appendectomy (TULAA) combines advantages of open surgery with benefits of laparoscopy and can be performed either by single-incision or with two trocars; the present study aims to compare outcomes and cost of these techniques in a pediatric serie. MATERIAL AND METHODS: Patients undergoing TULAA between July 2013 and June 2014 were retrospectively reviewed. There were two groups: A (single-incision) - one umbilical trocar for a telescope with inbuilt working channel; and B (2-trocar) - one umbilical trocar for a 'standard' telescope plus a supra-pubic trocar for instruments...
November 13, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29130557/out-of-sight-out-of-mind-perforated-distal-stump-appendicitis
#19
Khadijah Nadeem, Mathew O Jacob, Ollapallil Jacob
No abstract text is available yet for this article.
November 12, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29130464/boronic-acid-recognition-of-non-interacting-carbohydrates-for-biomedical-applications-increasing-fluorescence-signals-of-minimally-interacting-aldoses-and-sucralose
#20
Angel Resendez, Md Abdul Halim, Jasmeet Singh, Dominic-Luc Webb, Bakthan Singaram
To address carbohydrates that are commonly used in biomedical applications with low binding affinities for boronic acid based detection systems, two chemical modification methods were utilized to increase sensitivity. Modified carbohydrates were analyzed using a two component fluorescent probe based on boronic acid-appended viologen-HPTS (4,4'-o-BBV). Carbohydrates normally giving poor signals (fucose, l-rhamnose, xylose) were subjected to sodium borohydride (NaBH4) reduction in ambient conditions for 1 h yielding the corresponding sugar alcohols from fucose, l-rhamnose and xylose in essentially quantitative yields...
November 13, 2017: Organic & Biomolecular Chemistry
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