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https://www.readbyqxmd.com/read/28230172/evidence-for-critical-role-of-lymphocyte-cytosolic-protein-1-in-oral-cancer
#1
Nao Koide, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Sho Ishida, Toshihiro Shimizu, Yasushi Kimura, Isao Miyamoto, Shusaku Yoshimura, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Lymphocyte cytosolic protein 1 (LCP1), a member of actin-binding protein of the plastin family, has been identified in several malignant tumors of non-hematopoietic sites, such as the colon, prostate, and breast. However, little is known about the roles of LCP1 in oral squamous cell carcinomas (OSCCs). This present study sought to clarify the clinical relevance of LCP1 in OSCCs and investigate possible clinical applications for treating OSCCs by regulating LCP1 expression. We found up-regulation of LCP1in OSCCs compared with normal counterparts using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), immunoblotting, and immunohistochemistry (P < 0...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28223824/mir182-activates-the-ras-mek-erk-pathway-in-human-oral-cavity-squamous-cell-carcinoma-by-suppressing-rasa1-and-spred1
#2
Jinhui Wang, Wei Wang, Jichen Li, Liji Wu, Mei Song, Qinggang Meng
PURPOSE: The constitutive activation of the Ras-MEK-ERK signaling pathway in oral cavity squamous cell carcinoma (OSCC) has been found to be tightly controlled at multiple levels under physiological conditions. RASA1 and SPRED1 are two important negative regulators of this pathway, but the exact regulating mechanism remains unclear. In this study, we aimed to explore the potential regulating mechanisms involved in the Ras-MEK-ERK signaling pathway in OSCC. MATERIALS AND METHODS: MicroRNA (miRNA) expression was detected by quantitative reverse-transcription polymerase chain reaction...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28218707/fkbp51-immunohistochemical-expression-a-new-prognostic-biomarker-for-oscc
#3
Daniela Russo, Francesco Merolla, Massimo Mascolo, Gennaro Ilardi, Simona Romano, Silvia Varricchio, Virginia Napolitano, Angela Celetti, Loredana Postiglione, Pier Paolo Di Lorenzo, Luigi Califano, Giovanni Orabona Dell'Aversana, Fabio Astarita, Maria Fiammetta Romano, Stefania Staibano
Up-to-date, several molecular markers of prognosis have been studied in Oral Squamous Cell Carcinoma (OSCC), but none entered in the clinical setting. Therapy of OSCC tumors mainly relies on surgery, radiotherapy and partially on chemotherapy; there is an urgent need for biomarkers able to better stratify OSCC patients' risk to address targeted therapeutic strategies. The role of immune response in the pathogenesis and biological behavior of OSCC has been investigated by several authors, and promising results have been obtained with immune checkpoint inhibitors...
February 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28215944/cd44-cancer-cell-induced-metastasis-a-feasible-neck-metastasis-model
#4
Tian-Fu Wu, Lei Chen, Lin-Lin Bu, Jie Gao, Wen-Feng Zhang, Jun Jia
Neck metastasis of oral squamous cell carcinoma (OSCC) indicates a poor prognosis. Few neck metastasis models are currently available for drug trials and clinical research on OSCC. This study constructed a feasible animal model of neck metastasis by using CD44+ stem cell-like cancer cells. Real-time PCR was used to determine the expression levels of several reported cancer stem cell (CSC) markers, including CD44, CD133, ALDH1 and OCT4, in three OSCC cell lines. Magnetic sorting and DiO/DiD labelling were used to isolate subpopulations of cells and monitor cancer cell migration...
February 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28214216/cancer-stem-cell-cytokeratins-and-epithelial-to-mesenchymal-transition-markers-expression-in-oral-squamous-cell-carcinoma-derived-from-ortothopic-xenoimplantation-of-cd44-high-cells
#5
Nathália Paiva de Andrade, Maria Fernanda Setúbal Destro Rodrigues, Camila Oliveira Rodini, Fabio Daumas Nunes
Oral squamous cell carcinoma (OSCC) is the most prevalent neoplasia of oral cavity worldwide and prognosis remains unchanged in decades. Recently, different authors reported that head and neck squamous cell carcinomas have a subpopulation of tumor initiating cells that apparently correspond to cancer stem cells (CSC) and are also responsible for tumor growth and metastasis. The purpose of the present study was to investigate the microscopic and phenotypic characteristics of OSCC tumors induced after orthotopic xenoimplantation of SCC9(WT) cell line and CSC-enriched subpopulation isolated from SCC9 cell line based on high expression of the putative CSC marker CD44...
December 23, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28212555/construction-of-a-pathological-risk-model-of-occult-lymph-node-metastases-for-prognostication-by-semi-automated-image-analysis-of-tumor-budding-in-early-stage-oral-squamous-cell-carcinoma
#6
Nicklas Juel Pedersen, David Hebbelstrup Jensen, Giedrius Lelkaitis, Katalin Kiss, Birgitte Charabi, Lena Specht, Christian von Buchwald
It is challenging to identify at diagnosis those patients with early oral squamous cell carcinoma (OSCC), who have a poor prognosis and those that have a high risk of harboring occult lymph node metastases. The aim of this study was to develop a standardized and objective digital scoring method to evaluate the predictive value of tumor budding. We developed a semi-automated image-analysis algorithm, Digital Tumor Bud Count (DTBC), to evaluate tumor budding. The algorithm was tested in 222 consecutive patients with early-stage OSCC and major endpoints were overall (OS) and progression free survival (PFS)...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28209617/loss-of-ndrg2-expression-confers-oral-squamous-cell-carcinoma-with-enhanced-metastatic-potential
#7
Tomohiro Tamura, Tomonaga Ichikawa, Shingo Nakahata, Yudai Kondo, Yuri Tagawa, Kouji Yamamoto, Kentaro Nagai, Takashi Baba, Ryoji Yamaguchi, Mitsuru Futakuchi, Yoshihiro Yamashita, Kazuhiro Morishita
Loss of the tumor suppressor NDRG2 has been implicated in the development of oral squamous cell carcinoma (OSCC), acting by modulating PI3K/AKT-mediated dephosphorylation of PTEN at S380/S382/T383 (STT). Here we show that the majority of OSCC tumors with lymph node metastasis, a major prognostic factor, exhibit high levels of phosphorylated AKT-S473 and PTEN-STT and low levels of NDRG2 expression. In Ndrg2-deficient mice, which develop a wide range of tumors, we developed a model of OSCC by treatment with the tobacco surrogate 4-nitroquinoline-1-oxide (4-NQO)...
February 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28199027/investigating-the-level-of-salivary-endothelin-1-in-premalignant-and-malignant-lesions
#8
Tahereh Nosratzehi, Sirous Risbaf Fakour, Ebrahim Alijani, Maryam Salehi
PURPOSE: This study aimed to investigate the level of salivary endothelin-1 in premalignant and malignant lesions. MATERIALS AND METHODS: In this study, 75 cases were investigated of which 25 cases were healthy, 25 cases had oral lichen planus (OLP), and 25 cases had oral squamous cell carcinoma (OSCC). In order to collect the saliva samples, the unstimulated spitting was used. The samples were collected between 9 and 12 a.m. They were sent to the lab shortly after being collected and salivary endothelin-1 was recorded for each sample according to the instruction of factory by using enzyme-linked immunosorbent assay and optical density at a wavelength of 450 nm...
February 15, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28198666/design-connecting-gene-expression-with-therapeutics-for-drug-repurposing-and-development
#9
Bernard Kok Bang Lee, Kai Hung Tiong, Jit Kang Chang, Chee Sun Liew, Zainal Ariff Abdul Rahman, Aik Choon Tan, Tsung Fei Khang, Sok Ching Cheong
BACKGROUND: The drug discovery and development pipeline is a long and arduous process that inevitably hampers rapid drug development. Therefore, strategies to improve the efficiency of drug development are urgently needed to enable effective drugs to enter the clinic. Precision medicine has demonstrated that genetic features of cancer cells can be used for predicting drug response, and emerging evidence suggest that gene-drug connections could be predicted more accurately by exploring the cumulative effects of many genes simultaneously...
January 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28195638/significant-changes-in-sexual-behavior-after-a-diagnosis-of-human-papillomavirus-positive-and-human-papillomavirus-negative-oral-cancer
#10
Miren Taberna, Ronald C Inglehart, Robert K L Pickard, Carole Fakhry, Amit Agrawal, Mira L Katz, Maura L Gillison
BACKGROUND: Sexual behavior and oral human papillomavirus (HPV) infection are risk factors for oral squamous cell carcinoma (OSCC). The effects of OSCC diagnosis and treatment on subsequent relationship stress and sexual behavior are unknown. METHODS: Incident cases of HPV-positive or HPV-negative OSCC in patients who had a partnered relationship and partners of patients with oropharyngeal cancer were eligible for a study in which surveys were administered at diagnosis and at the 6-month follow-up time point to assess relationship distress, HPV transmission and concerns about health consequences, and sexual behavior...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28186650/p16-and-p53-in-hpv-positive-versus-hpv-negative-oral-squamous-cell-carcinoma-oscc-do-pathways-differ
#11
Vineeta Singh, Nuzhat Husain, Naseem Akhtar, M Y Khan, Abhinav A Sonkar, Vijay Kumar
BACKGROUND: p16 overexpression and wild-type p53 expression is associated with human papilloma virus (HPV) in cervical and oropharyngeal cancer. Role of HPV-related carcinogenesis in the etiology of oral squamous cell carcinoma (OSCC) is still vague in Indian population. We aimed to explore the expression pattern of p16 and p53 in HPV positive and HPV negative OSCC to elicit differences, if any. Further their effect on survival of patients was studied. METHODS: Thirty-one consecutive HPV positive as well as 31 age and sex matched HPV negative OSCC cases from a case series of 369 histologically diagnosed cases of OSCC were included in this study...
February 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28182650/tropomyosin-1-acts-as-a-potential-tumor-suppressor-in-human-oral-squamous-cell-carcinoma
#12
Hao Pan, Liqun Gu, Binjie Liu, Yiping Li, Yuehong Wang, Xinna Bai, Long Li, Baisheng Wang, Qian Peng, Zhigang Yao, Zhangui Tang
It is widely accepted that oral squamous cell carcinoma (OSCC) is a major contributor to the incidence and mortality of neck and head cancer. Tropomyosin-1 (TPM1), which is expressed at a low level, has been considered a prominent tumor-suppressing gene in a variety of solid tumors, although the precise mechanism of the TPM1 gene in OSCC progression remains unknown. We found that TPM1 expression levels decreased in OSCC patients and OSCC cell lines. The overall and cancer-specific survival of patients who exhibited low TPM1 levels were inferior to those of patients who had high TPM1 levels...
2017: PloS One
https://www.readbyqxmd.com/read/28182055/ultrastructural-analysis-of-oral-exfoliated-epithelial-cells-of-tobacco-smokers-and-betel-nut-chewers-a-scanning-electron-microscopy-study
#13
Sameera Shamim Khan, Balasundari Shreedhar, Mala Kamboj
BACKGROUND: The study was undertaken to correlate epithelial surface pattern changes of oral exfoliated cells of tobacco smokers and betel nut chewers and also to compare them with patients of oral squamous cell carcinoma (OSCC) and healthy individuals. MATERIALS AND METHODS: In this cross-sectional study, a total of fifty persons were included in the study, out of which thirty formed the study group (15 each tobacco smokers and betel nut chewers) and twenty formed the control group (ten each of OSCC patients - positive control and ten normal buccal mucosa - negative control)...
November 2016: Dental Research Journal
https://www.readbyqxmd.com/read/28181403/caffeic-acid-phenethyl-ester-upregulates-n-myc-downstream-regulated-gene-1-via-erk-pathway-to-inhibit-human-oral-cancer-cell-growth-in-vitro-and-in-vivo
#14
Li-Chuan Chung, Kun-Chun Chiang, Tsui-Hsia Feng, Kang-Shuo Chang, Sung-Ting Chuang, Yu-Jen Chen, Ke-Hung Tsui, Jehn-Chuan Lee, Horng-Heng Juang
SCOPE: Caffeic acid phenethyl ester (CAPE), a bioactive component of propolis, is considered as a new anti-cancer agent. Oral squamous cell carcinoma (OSCC) is the most common oral cancer with unsatisfying survival. N-myc downstream regulated family genes (NDRGs) involve in numerous physiological processes. We investigated the anti-cancer effect of CAPE on OSCC and related mechanisms. METHODS AND RESULTS: Cell proliferation assay, western blot, gene transfection and knockdown, and reporter assay were applied...
February 9, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28176846/prediction-of-biomarkers-of-oral-squamous-cell-carcinoma-using-microarray-technology
#15
Guang Li, Xian Li, Meng Yang, Lvzi Xu, Shixiong Deng, Longke Ran
Microarray data is used to screen the genes of oral squamous cell carcinoma (OSCC). Microarray data of OSCC and normal tissues were downloaded from GEO database and analyzed with Benjamini-Hochberg (BH) method. Differentially expressed genes (DEGs) were then uploaded on DAVID database to process enrichment analysis. Target genes were finally chosen for verification experiment in vitro and in vivo. 78 DEGs were selected from 54676 genes, including 46 up- and 32 down- regulation. GO term showed that these genes were related to epidermal growth (biological processes), extracellular region (cellular components) and cytokines activity (molecular function)...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28176233/inhibiting-reactive-oxygen-species-dependent-autophagy-enhanced-baicalein-induced-apoptosis-in-oral-squamous-cell-carcinoma
#16
Bo Li, Mei Lu, Xin-Xiang Jiang, Meng-Xiong Pan, Jun-Wu Mao, Mei Chen
Autophagy modulation has been considered a potential therapeutic strategy for oral squamous cell carcinoma (OSCC). A previous study confirmed that baicalein might possess significant anti-carcinogenic activity. However, whether baicalein induces autophagy and its role in cell death in OSCC are still unclear. The aim of this study was to investigate the anticancer activity and molecular targets of baicalein in OSCC in vitro. In this study, we found that baicalein induced significant apoptosis in OSCC cells Cal27...
February 7, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28174608/genome-wide-dna-methylation-profile-identified-a-unique-set-of-differentially-methylated-immune-genes-in-oral-squamous-cell-carcinoma-patients-in-india
#17
Baidehi Basu, Joyeeta Chakraborty, Aditi Chandra, Atul Katarkar, Jadav Ritesh Kumar Baldevbhai, Debjit Dhar Chowdhury, Jay Gopal Ray, Keya Chaudhuri, Raghunath Chatterjee
BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the common malignancies in Southeast Asia. Epigenetic changes, mainly the altered DNA methylation, have been implicated in many cancers. Considering the varied environmental and genotoxic exposures among the Indian population, we conducted a genome-wide DNA methylation study on paired tumor and adjacent normal tissues of ten well-differentiated OSCC patients and validated in an additional 53 well-differentiated OSCC and adjacent normal samples...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28174335/microrna-143-suppresses-oral-squamous-cell-carcinoma-oscc-cell-growth-invasion-and-glucose-metabolism-through-targeting-hexokinase2
#18
Xianghui Sun, Lei Zhang
MicroRNAs are non-coding RNAs that have functions to regulate gene expression and play essential roles in a variety of biological processes of cancers. In this study, we report miR-143 acts as a tumor suppressor in human oral squamous cell carcinoma (OSCC). The expressions of miR-143 are downregulated in both oral squamous cell carcinoma cell lines and patient samples compared with normal adjacent tissues. We found overexpression of miR-143 in oral cancer cell lines suppresses cell migration, cellular glucose metabolism and proliferation...
February 7, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28174027/forkhead-box-p3-regulatory-t-cells-and-toll-like-receptor-2-co-expression-in-oral-squamous-cell-carcinoma
#19
H M Hussaini, V P B Parachuru, G J Seymour, A M Rich
BACKGROUND: The function of forkhead box-P3 (FoxP3) regulatory T cells (Treg) and toll-like receptor (TLR)2 protein in the oral cancer microenvironment is not fully understood, but evidence from other malignancies suggests it is likely they are involved with tumour development and progression. The aim of this study was to investigate the distribution of FoxP3(+)cells, TLR2(+) cells and double-labelled FoxP3(+)TLR2(+) immune cells in oral squamous cell carcinoma (OSCC), using immunohistochemistry (IHC) and immunofluorescence (IF)...
February 4, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28165332/exhaled-breath-and-oral-cavity-vocs-as-potential-biomarkers-in-oral-cancer-patients
#20
Marcos Bouza, Jesus Gonzalez-Soto, Rosario Pereiro, Juan Carlos de Vicente, Alfredo Sanz-Medel
Corporal mechanisms attributed to cancer, such as oxidative stress or the action of cytochrome P450 enzymes, seem to be responsible of the generation of a variety of volatile organic compounds (VOCs) that could be used as non-invasive diagnosis biomarkers. The present work presents an attempt of using VOCs from exhaled breath and oral cavity air as biomarkers for oral squamous cell carcinoma (OSCC) patients. 52 breath samples were collected (3 L Tedlar bags) from 26 OSCC patients and 26 cancer-free controls...
February 6, 2017: Journal of Breath Research
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