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https://www.readbyqxmd.com/read/29332355/antitumor-activity-of-4-o-methylhonokiol-in-human-oral-cancer-cells-is-mediated-via-ros-generation-disruption-of-mitochondrial-potential-cell-cycle-arrest-and-modulation-of-bcl-2-bax-proteins
#1
Sha Xiao, Fan Chen, Chengzhi Gao
PURPOSE: The plant-derived natural product 4-O-methylhonokiol (MH) has been reported to possess tremendous pharmacological potential ranging from neuroprotection to anticancer activity. However, the anticancer activity of MH in oral squamous cell carcinoma (OSCC) cells has not been evaluated. In the present study, MH was evaluated for its anticancer activity against OSSC PE/CA-PJ41 cells and the possible underlying mechanism was determined. METHODS: Cell cytotoxicity was evaluated by colorimetrybased MTT assay while the effects on cell cycle phase distribution were assessed by flow cytometry...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332186/assessment-of-oral-cancer-pain-anxiety-and-quality-of-life-of-oral-squamous-cell-carcinoma-patients-with-invasive-treatment-procedure
#2
Endang Sjamsudin, Tantry Maulina, Ahmad Cipta, Aulia Iskandarsyah, Andri Hardianto, Mantra Nandini, Alwin Kasim, Harmas Yazid Yusuf
PURPOSE: Depending on its stage on diagnosis, oral squamous cell carcinoma (OSCC) might cause excruciating pain and decreased quality of life. As for treatment, the treatment of OSCC might vary from chemotherapy to surgery. The objective of the current study was to assess the preoperative and postoperative oral cancer pain, anxiety, and quality of life of OSCC patients with invasive treatment procedure. METHODS: The current study was conducted by interviewing 21 (10 males; 11 females) patients who had been diagnosed with stage 3 and stage 4 OSCC and about to go through surgery at the inpatient ward of Surgical Oncology Department, Hasan Sadikin Hospital, Bandung, Indonesia...
January 13, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29330528/application-of-weighted-gene-co-expression-network-analysis-for-data-from-paired-design
#3
Jianqiang Li, Doudou Zhou, Weiliang Qiu, Yuliang Shi, Ji-Jiang Yang, Shi Chen, Qing Wang, Hui Pan
Investigating how genes jointly affect complex human diseases is important, yet challenging. The network approach (e.g., weighted gene co-expression network analysis (WGCNA)) is a powerful tool. However, genomic data usually contain substantial batch effects, which could mask true genomic signals. Paired design is a powerful tool that can reduce batch effects. However, it is currently unclear how to appropriately apply WGCNA to genomic data from paired design. In this paper, we modified the current WGCNA pipeline to analyse high-throughput genomic data from paired design...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330429/tissue-and-serum-microrna-profile-of-oral-squamous-cell-carcinoma-patients
#4
Augusto Schneider, Berta Victoria, Yury Nunez Lopez, Wiktoria Suchorska, Wojciech Barczak, Agnieszka Sobecka, Wojciech Golusinski, Michal M Masternak, Pawel Golusinski
Head and neck cancer is characterized by malignant tumors arising from the epithelium covering the upper aerodigestive tract, and the majority of these epithelial malignancies are squamous cell carcinomas (SCCs) of the oral cavity (OSCCs). The aim of the current work was to identify miRNAs regulated in OSCC cancerous tissue when compared to a healthy adjacent tissue and to verify the presence of the same miRNAs in the circulation of these patients. For that serum samples and biopsies of healthy and tumor tissues were collected from five patients diagnosed with OSCC of the oral cavity, RNA was extracted from these samples and microRNAs libraries were prepared and sequenced...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330202/high-risk-tp53-mutations-are-associated-with-extra-nodal-extension-ene-in-oral-cavity-squamous-cell-carcinoma-oscc
#5
Vlad C Sandulache, Chieko Michikawa, Pranav Kataria, Frederico O Gleber-Netto, Diana Bell, Sanchit Trivedi, Xiayu Rao, Jing Wang, Mei Zhao, Samar A Jasser, Jeffrey N Myers, Curtis R Pickering
PURPOSE:   Development of extra-nodal extension (ENE) has been associated with poor survival in patients with oral cavity squamous cell carcinoma (OSCC). Here we sought to confirm the role of ENE as a poor prognostic factor, and identify genomic and epigenetic markers of ENE in order to develop a predictive model and improve treatment selection. EXPERIMENTAL DESIGN: An institutional cohort (University of Texas MD Anderson Cancer Center) was utilized to confirm the impact of ENE on clinical outcomes and evaluate the genomic signature of primary and ENE containing tissue...
January 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29328386/proteomics-based-investigation-of-multiple-stages-of-oscc-development-indicates-that-the-inhibition-of-trx-1-delays-oral-malignant-transformation
#6
Xijuan Chen, Qinchao Hu, Tong Wu, Chunyang Wang, Juan Xia, Linglan Yang, Bin Cheng, Xiaobing Chen
The majority of cases of oral squamous cell carcinoma (OSCC) develop from oral potentially malignant disorders, which have been confirmed to be involved in chronic oxidative stimulation. However, no effective treatment approaches have been used to prevent the development of dysplasia into cancerous lesions thus far. In the present study, a well-established OSCC model was used to detect proteomics profiles at different stages during oral malignant transformation. Of the 15 proteins that were found to be upregulated in both the dysplasia and carcinoma stages, the oxidative stress-associated proteins, thioredoxin-1 (Trx-1), glutaredoxin-1 and peroxiredoxin-2 were note as the proteins with significant changes in expression Trx-1 was identified to be the most significantly upregulated protein in the precancerous stage...
January 3, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29327476/o-glcnacylation-in-oral-squamous-cell-carcinoma
#7
Tassaporn Kongkaew, Win Pa Pa Aung, Chayarop Supanchart, Anupong Makeudom, Sarawat Langsa-Ard, Thanapat Sastraruji, Ponlatham Chaiyarit, Suttichai Krisanaprakornkit
BACKGROUND: Two post-translational mechanisms commonly demonstrated in various cancers are protein phosphorylation and glycosylation by O-linked β-N-acetylglucosamine (O-GlcNAc). However, only phosphorylation of the epidermal growth factor receptor (EGFR)/Akt pathway has been reported in oral squamous cell carcinoma (OSCC). Therefore, we aimed to determine both post-translational modifications in OSCC tissues and in oral cancer cells compared to normal tissues and oral keratinocytes and to find correlations of these modifications with histological grading...
January 11, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29323724/autoregulation-of-rank-ligand-in-oral-squamous-cell-carcinoma-tumor-cells
#8
Yuvaraj Sambandam, Purushoth Ethiraj, Jessica Hathway-Schrader, Chad Novince, Ezhil Panneerselvam, Kumaran Sundaram, Sakamuri V Reddy
Oral squamous cell carcinoma (OSCC) is the most common malignancy among oral cancers and shows potent activity for local bone invasion. Receptor activator of nuclear factor κB (RANK) ligand (RANKL) is critical for bone-resorbing osteoclast formation. We previously demonstrated that OSCC tumor cells express high levels of RANKL. In this study, confocal microscopy demonstrated RANKL specific receptor, RANK expression in OSCC tumor cell lines (SCC1, SCC12 and SCC14a). We also confirmed the expression of RANK and RANKL in primary human OSCC tumor specimens...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29323067/modified-cajal-s-trichrome-stain-as-a-diagnostic-aid-in-the-study-of-epithelial-pathology
#9
Karpagaselvi Sanjai, Anjum Baker, Lokesh Papiah Reddy, Bhavna Pandey
BACKGROUND: Diagnosis of initial epithelial pathology maybe difficult in Squamous Cell Carcinoma (SCC), Carcinoma In Situ and other atypical epithelial malignancies, under routine Haematoxylin and Eosin (H and E) stain. The detection of minor basement membrane alterations in doubtful cases is both time consuming and confusing. AIMS: To evaluate efficacy of Modified Cajal's Trichrome Stain (CTS) in relation to Haematoxylin and Eosin for study of epithelial dysplasia, carcinoma in situ, micro invasive SCC, frank SCC, and SCC in lymph nodes...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29323056/role-of-salivary-biomarkers-in-early-detection-of-oral-squamous-cell-carcinoma
#10
Nidhi Awasthi
INTRODUCTION: Oral cancer is prevalent worldwide and is a common cause of morbidity and mortality. Despite advances in treatment, the survival of patients with oral cancer has not significantly improved over the past several decades owing to late detection and treatment failures. The present study was undertaken with an objective to explore the role of salivary CYFRA 21-1, CA 19-9, lactate dehydrogenase (LDH), total proteins, and amylase as biochemical markers of oral squamous cell carcinoma (OSCC) and premalignant lesions (PML)...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29322606/association-of-tumour-infiltrating-regulatory-t-cells-with-adverse-outcomes-in-dogs-with-malignant-tumours
#11
K Sakai, S Maeda, Y Yamada, J K Chambers, K Uchida, H Nakayama, T Yonezawa, N Matsuki
Regulatory T cells (Tregs) infiltrate into a variety of tumour tissues and associate with poor prognosis in humans. However, data on association of Treg infiltration with prognosis is limited in canine tumours. The purpose of this study was to examine the number of tumour-infiltrating Tregs and its association with overall survival (OS) in dogs with malignant tumours. The following 168 canine tumours were included: 37 oral malignant melanomas (OMMs); 14 oral squamous cell carcinomas (OSCCs); 16 pulmonary adenocarcinomas (PAs); 37 mammary carcinomas (MCs); 36 mast cell tumours (MCTs) and 28 hepatocellular carcinomas (HCCs)...
January 11, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29321718/a-novel-notch1-missense-mutation-c1133y-in-the-abruptex-domain-exhibits-enhanced-proliferation-and-invasion-in-oral-squamous-cell-carcinoma
#12
Yang Zheng, Zhao Wang, Xu Ding, Wei Zhang, Gang Li, Laikui Liu, Heming Wu, Wenyi Gu, Yunong Wu, Xiaomeng Song
Background: Notch1 has been regarded as a fundamental regulator in tissue differentiation and stem cell properties. Recently, Notch1 mutations have been reported intensively both in solid tumors and in hematopoietic malignancies. However, little is known about the biological effect and the clinical implication of these reported mutations. Previously, we discovered several missense mutations in the Notch1 receptor in a Chinese population with oral squamous cell carcinoma (OSCC). Methods: We selected a 'hotspot' mutation in the Abruptex domain (C1133Y)...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29319163/microrna-22-suppresses-cell-proliferation-migration-and-invasion-in-oral-squamous-cell-carcinoma-by-targeting-nlrp3
#13
Xiaodong Feng, Qingqiong Luo, Han Wang, Han Zhang, Fuxiang Chen
MicroRNAs (miRNAs) have been implicated as important regulators of carcinogenesis and tumor development. Recently, microRNA-22 (miR-22) has been reported to be a cancer-related miRNA in several types of tumors. In this study, we aimed to investigate the role of miR-22 in oral squamous cell carcinoma (OSCC). We found that miR-22 expression was significantly decreased in OSCC tissues compared with that in the adjacent noncancerous tissues. Furthermore, lentivirus-mediated miR-22 overexpression markedly reduced OSCC cell viability, migration and invasion, whereas miR-22 inhibitor promoted these parameters...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29316373/tanshinone-iia-induces-cell-death-via-beclin-1-dependent-autophagy-in-oral-squamous-cell-carcinoma-scc-9-cell-line
#14
Ye Qiu, Conghua Li, Qinhua Wang, Xingqi Zeng, Ping Ji
Tanshinone IIA (TAN) is one of the major functional compounds of Salvia miltiorrhiza Bunge and possesses the ability to suppress the growth of multiple cancer cell types via its apoptosis- and autophagy-inducing functions. In this study, the effect of TAN therapy on the survival of oral squamous cell carcinoma (OSCC) was evaluated, and the underlying mechanism involved in the treatment was investigated. Human oral squamous cell carcinoma cell SCC-9 was used for in vitro assays and induction in an OSCC xenograft mouse model...
January 6, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29315816/uncovering-the-potential-of-cd44v-syne1-mir34a-axis-in-salivary-fluids-of-oral-cancer-patients
#15
Kavan Shah, Shanaya Patel, Bansri Modi, Franky Shah, Rakesh Rawal
OBJECTIVES: Late stage diagnosis is one of the major confounders for poor prognosis of oral cancer patients owing to lack of a biomarker to diagnose this disease at an early stage. Moreover, till date invasive biopsies are the only option to assess disease occurrence and progression in this malignancy. Thus, this study aims to identify and assess potential salivary markers in OSCC patients in order to open newer avenues in the field of non-invasive biopsies. METHODOLOGY: Bioinformatic based analysis were performed to identify potential biomarkers that could be assessed in OSCC patients...
January 8, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29313371/utility-of-3-month-surveillance-f-18-fdg-pet-ct-in-surgically-resected-oral-squamous-cell-carcinoma
#16
Michael Marquardt, Carryn Anderson, Timothy Ginader, Jessica Parkhurst, Nitin Pagedar, Rodrigo Bayon, Gerald Clamon, Andrew Hoover, John Buatti
OBJECTIVES: To evaluate the performance of surveillance F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) 1 year after imaging in oral squamous cell carcinoma (OSCC) patients treated with definitive surgery and adjuvant (chemo)radiotherapy (RT). METHODS AND MATERIALS: Surveillance PET/CT accuracy was retrospectively evaluated in OSCC patients receiving surgical resection and (chemo)RT. Pathologic risk factors were assessed for influence on accuracy of the post-RT PET/CT...
January 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29305191/decreased-cytoplasmic-x-box-binding-protein-1-expression-is-associated-with-poor-prognosis-and-overall-survival-in-patients-with-oral-squamous-cell-carcinoma
#17
Hui-Ting Hsu, Ming-Tai Hsing, Chung-Min Yeh, Chih-Jung Chen, Jia-Sin Yang, Kun-Tu Yeh
INTRODUCTION: Squamous cell carcinoma is the most common cancer of the oral cavity. In spite of advancements in surgical, chemoradiological and targeted therapies, these therapeutic strategies still have had little impact on survival rates. X-box binding protein-1 (XBP-1) is a potent transcription factor that is involved in the unfolded protein response (UPR) pathway, which itself is activated in response to endoplasmic reticulum stress as a method to restore cellular homeostasis. The role XBP-1 plays in oral squamous cell carcinoma (OSCC) has yet to be determined...
January 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29298397/impact-of-hotair-gene-polymorphism-and-environmental-risk-on-oral-cancer
#18
S C Su, M J Hsieh, C W Lin, C Y Chuang, Y F Liu, C M Yeh, S F Yang
Genetic and acquired factors are thought to be interrelated and imperative to estimate the risk and prognosis of oral squamous cell carcinoma (OSCC). HOX transcript antisense intergenic RNA ( HOTAIR) plays crucial roles in gene regulation and is regulated in a variety of cancers. Polymorphisms in HOTAIR have been recently linked to the predisposition to diverse malignancies. In the present study, we aimed to evaluate the influences of HOTAIR gene polymorphisms, combined with environmental triggers, on the susceptibility to oral tumorigenesis...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29297550/demographic-and-clinical-profile-of-oral-squamous-cell-carcinoma-from-a-service-based-population
#19
Alessandro Menna Alves, Marcos Britto Correa, Karine Duarte da Silva, Lenita Maria Aver de Araújo, Ana Carolina Uchoa Vasconcelos, Ana Paula Neutzling Gomes, Adriana Etges, Sandra Beatriz Chaves Tarquinio
The aim of this study was to evaluate the demographic and clinical profile of the oral squamous cells carcinoma (OSCC) cases registered in a center of oral diagnosis in southern Brazil. Eight hundred and six individuals with OSCC from 1959 to 2012 were included in this study. The variables recorded were: sex, age, occupation according to workplace, alcohol and tobacco consumption, skin color, tumor location, histological type, clinical appearance, size, evolution time, presence of pain and lymph node metastasis...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29296179/identification-and-validation-long-non-coding-rnas-of-oral-squamous-cell-carcinoma-by-bioinformatics-method
#20
Meng Yang, Xingliang Xiong, Longcong Chen, Li Yang, Xian Li
Gene markers of oral squamous cell carcinoma (OSCC) have great significance on early diagnosis and treatment of clinical oral cancer. In this study, we used RNA-Seq data from OSCC patients and filtered differentially-expressed long non-coding RNA (lncRNA) to further clarify the molecular mechanism. Firstly, we downloaded datasets of OSCC from National Center for Biotechnology Information(NCBI), which were predicted and analyzed by cufflinks and tophat. Then, differentially expressed lncRNA enrichment was performed with The Database for Annotation, Visualization and Integrated Discovery (DAVID)...
December 8, 2017: Oncotarget
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