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https://www.readbyqxmd.com/read/28929330/development-of-a-rapid-analysis-method-for-bone-resection-margins-for-oral-squamous-cell-carcinoma-by-immunoblotting
#1
Claudia Haase, Bernd Lethaus, Ruth Knüchel-Clarke, Frank Hölzle, Angela Cassataro, Till Braunschweig
The purpose of this proof-of-principle study was to develop a rapid and approachable method to analyse bone resection margins in patients with oral squamous cell carcinoma (OSCC) in an intraoperative setting, similar to assessing frozen sections of soft tissue. Bone excision and risk of remaining tumour cells could be minimised, thus improving reconstruction measures and facilitating convalescence. Frozen, sawed wafers of porcine bone artificially combined with porcine skin (simulating OSCC properties) were used to develop and evaluate a new molecular method: protein transfer from non-decalcified, sawed wafers onto a membrane stained by immunofluorescence (Tissue-ProtTrans)...
September 19, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28928781/n-acetylneuraminic-acid-a-scrutinizing-tool-in-oral-squamous-cell-carcinoma-diagnosis
#2
Suganya Rajaram, Balamurali P Danasekaran, Ramesh Venkatachalapathy, Karthikshree Vishnu Prashad, Saranya Rajaram
BACKGROUND: Oral cancer has one of the highest mortality rate among other malignancies. An attempt has been made to assess the genetic expression of a cell surface glycoprotein component - sialic acid released by the malignant cells which will reflect on the oral squamous cell carcinoma (OSCC). The aim of this study was to estimate and correlate the salivary and serum sialic acid levels in OSCC. MATERIALS AND METHODS: In our case-control study, saliva and blood samples were obtained from Group 1 - 10 healthy controls, Group 2 - 12 well-differentiated OSCC, Group 3 - 7 moderately differentiated and 2 poorly differentiated OSCC...
July 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28927136/low-risk-population-among-patients-with-tumor-node-metastasis-stage-iii-iv-oral-squamous-cell-carcinoma
#3
Tohru Ikeda, Sachiko Seki, Mutsunori Fujiwara, Masaaki Matsuura, Yuu Ozaki-Honda, Shuichi Fujita, Hisazumi Ikeda, Masahiro Umeda, Izumi Asahina
A novel system auxiliary to the Union for International Cancer Control classification may allow the prognosis of patients with malignant tumors at similar stages to be predicted, as currently this is challenging. The present study generated a novel system to predict populations at low risk among patients with stage III/IV oral squamous cell carcinoma (OSCC). A total of 41 patients who were diagnosed at stages III/IV OSCC and underwent surgical tumor resection were analyzed. Band-like or follicular lymphocyte infiltration, intraepithelial micro-abscess formation and natural killer (NK) cell infiltration were histopathologically evaluated...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927087/gimeracil-enhances-the-antitumor-effect-of-cisplatin-in-oral-squamous-cell-carcinoma-cells-in-vitro-and-in-vivo
#4
Koji Harada, Tarannum Ferdous, Toyoko Harada, Takanori Takenawa, Yoshiya Ueyama
Gimeracil or 5-chloro-2,4-dihydroxypyridine (CDHP) enhances the antitumor effects of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase (DPD), which is involved in the degradation of 5-FU. CDHP, as part of a combination therapy, was also reported to exert a radiosensitizing effect. Therefore, CDHP may have underlying mechanisms of action other than DPD inhibition. The focus of the present study was to investigate the antitumor effects of CDHP and cisplatin (CDDP) combination treatment in vitro and in vivo against oral squamous cell carcinoma (OSCC) tumors...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927031/prognostic-significance-of-the-epithelial-mesenchymal-transition-factor-zinc-finger-e-box-binding-homeobox-2-in-esophageal-squamous-cell-carcinoma
#5
Xiaodong Huo, Bin Huo, Huixing Wang, Hongdian Zhang, Zhao Ma, Mingjian Yang, Haitao Wang, Zhentao Yu
Zinc finger E-box-binding homeobox 2 (ZEB2) has been reported to mediate epithelial-mesenchymal transition (EMT) and disease progression in several cancer types. However, the expression of ZEB2 in esophageal squamous cell carcinoma (OSCC) and its association with prognosis remains unclear. In the present study, a tissue microarray and immunohistochemistry were used to investigate ZEB2 and epithelial (E-)cadherin expression in OSCC tissues (n=218) and peritumoral esophageal tissues (POT; n=60). There was a significantly increased incidence of positive ZEB2 expression in OSCC tissues compared with the expression in POTs (P<0...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926115/long-non-coding-rna-malat1-promotes-oral-squamous-cell-carcinoma-development-via-microrna-125b-stat3-axis
#6
Shi-Min Chang, Wei-Wei Hu
Oral squamous cell carcinoma (OSCC), as the most common type of oral cancer, is responsible for almost 3% of all malignant tumors worldwide. Non-coding RNAs such as lncRNAs and microRNAs have been involved in many cancers including OSCC. Recently, lncRNA metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) has been reported to play an oncogenic role in OSCC metastasis. However, the underlying mechanism of MALAT1 in regulating OSCC progression remains unclear. The aim of this study was to investigate the specific role of MALAT1 in OSCC development...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28924229/variations-in-oral-microbiota-associated-with-oral-cancer
#7
Hongsen Zhao, Min Chu, Zhengwei Huang, Xi Yang, Shujun Ran, Bin Hu, Chenping Zhang, Jingping Liang
Individual bacteria and shifts in microbiome composition are associated with human disease, including cancer. To unravel the connections underlying oral bacterial dysbiosis and oral squamous cell carcinoma (OSCC), cancer lesion samples and anatomically matched normal samples were obtained from the same patients. We then profiled the bacteria within OSCC lesion surface samples at the species level using next-generation sequencing to comprehensively investigate bacterial community composition and functional genes in these samples...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923838/syngeneic-mouse-models-of-oral-cancer-are-effectively-targeted-by-anti-cd44-based-nir-pit
#8
Tadanobu Nagaya, Yuko Nakamura, Shuhei Okuyama, Fusa Ogata, Yasuhiro Maruoka, Peter L Choyke, Clint Alen, Hisataka Kobayashi
Oral cavity squamous cell carcinoma (OSCC) is considered one of the most aggressive subtypes of cancer. Anti-CD44 monoclonal antibodies (mAbs) are a potential therapy against CD44 expressing OSCC, however, to date the therapeutic effects have been disappointing. Here, a new cancer treatment is described, near-infrared photoimmunotherapy (NIR-PIT), that uses anti-CD44 mAbs conjugated to the photoabsorber, IR700DX. This conjugate is injected into mice harboring one of three CD44 expressing syngeneic murine oral cancer cell (MOC) lines, MOC1 (immunogenic), MOC2 mKate2 (moderately immunogenic), and MOC2-luc (poorly immunogenic)...
September 18, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28922483/molecular-basis-of-oral-squamous-cell-carcinoma-in-young-patients-is-it-any-different-from-older-patients
#9
REVIEW
Sara Ferreira Dos Santos Costa, Peter A Brennan, Ricardo Santiago Gomez, Eduardo Rodrigues Fregnani, Alan Roger Santos-Silva, Manoela Domingues Martins, Gilberto de Castro-Junior, Siavash Rahimi, Felipe Paiva Fonseca
Oral squamous cell carcinoma (OSCC) is the commonest subtype of oral cancer, mainly affecting older patients. It used to be a rare disease among individuals younger than 40 years, but recently increased incidences in this age group are being reported worldwide. The pathogenesis of OSCC affecting young patients remains controversial and the well known etiological factors for oral cancer, tobacco and alcohol use, are believed to play a minor role in the carcinogenesis of the neoplasm, suggesting that the etiology and the molecular basis of OSCC may differ between younger and older patients...
September 18, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28918236/gene-expression-profiles-of-cell-adhesion-molecules-matrix-metalloproteinases-and-their-tissue-inhibitors-in-canine-oral-tumors
#10
Sirinun Pisamai, Anudep Rungsipipat, Chanin Kalpravidh, Gunnaporn Suriyaphol
Perturbation of cell adhesion can be essential for tumor cell invasion and metastasis, but the current knowledge on the gene expression of molecules that mediate cell adhesion in canine oral tumors is limited. The present study aimed to investigate changes in the gene expression of cell adhesion molecules (E-cadherin or CDH1, syndecan 1 or SDC1, NECTIN2 and NECTIN4), matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), in canine oral tumors, including benign tumors, oral melanoma (OM) and non-tonsillar oral squamous cell carcinoma (OSCC), by quantitative real-time reverse transcription PCR...
September 8, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28910982/exosomes-containing-mir-21-transfer-the-characteristic-of-cisplatin-resistance-by-targeting-pten-and-pdcd4-in-oral-squamous-cell-carcinoma
#11
Tao Liu, Gang Chen, Dawei Sun, Minghui Lei, Yongqiang Li, Changming Zhou, Xiaodong Li, Wei Xue, Hong Wang, Chunjun Liu, Jiang Xu
Resistance to chemotherapy remains a major obstacle for the effective treatment of oral squamous cell carcinoma (OSCC). Evidence for the involvement of exosomes as important regulators of cisplatin chemoresistance in OSCC is still poorly understood. Our objective of this study was to explore the roles for exosomes in modulating key cellular pathways mediating response to chemotherapy. We first developed the cisplatin-resistant cell lines (HSC-3-R and SCC-9-R) and found that the conditioned media from cisplatin-resistant OSCC cells enhanced the chemoresistance of parental OSCC cell...
September 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28910158/interaction-between-rare-variants-in-notch1-and-betel-quid-chewing-in-oral-squamous-cell-carcinoma
#12
Chia-Min Chung, Chien-Hung Lee, Mu-Kuan Chen, Ming-Hsui Tsai, Ying-Chin Ko
BACKGROUND: In this study, we investigated rare variants of the NOTCH1 gene located near somatic mutations as surrogate markers, as well as the relationship of these rare variants with betel quid (BQ) chewing and the occurrence of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: A total of 410 patients diagnosed with OSCC and 282 unrelated, healthy subjects without cancer were recruited from two medical centers in Taiwan. Odds ratios (OR) and 95% confidence intervals (CI) were assessed by logistic regression...
September 14, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28904918/evaluation-of-genetic-polymorphisms-in-glutathione-s-transferase-theta1-glutathione-s-transferase-mu1-and-glutathione-s-transferase-mu3-in-oral-leukoplakia-and-oral-squamous-cell-carcinoma-with-deleterious-habits-using-polymerase-chain-reaction
#13
Ayyagari Kameswara Rao, Peela Parameswar, Sumit Majumdar, Divya Uppala, Sreekanth Kotina, Naga Himabindu Vennamaneni
CONTEXT: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. As per previous studies, most patients who develop oral cancer are elderly males who are heavy users of tobacco and alcohol; however, the incidence is increasing in younger individuals and in those who neither smoke nor drink. Many of the genes that code for the detoxification enzymes are polymorphic with abnormal activity profiles. AIMS AND OBJECTIVES: The aim of this study was to evaluate the risk of development of oral leukoplakia (OLP) and OSCC in glutathione S-transferase polymorphisms genes in the east coast of Andhra Pradesh population with tobacco consumption habit and habit-free controls using polymerase chain reaction (PCR-restriction fragment length polymorphism)...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28904321/altered-expression-of-mitochondrial-antioxidants-in-oral-squamous-cell-carcinoma
#14
Sumita Banerjee, Saikat Mukherjee, Sanjib Mitra, Pallav Singhal
Reactive oxygen species, if produced in excess by oxidative phosphorylation, contributes to mitochondrial DNA damage and progressive respiratory chain dysfunction, leading to various diseases including carcinogenesis. Mitochondria are susceptible to oxidative stress (OS) owing to lack of introns, protective histones, and DNA repair enzymes. However, mitochondria are protected from OS by numerous antioxidants such as superoxide dismutase 2 (SOD2), catalase, glutaredoxin 2 (GLRX2), reduced glutathione (GSH), glutathione peroxidase (GPX), and thioredoxin 2 (TXN2)...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28903838/prognostic-potential-of-n-cadherin-in-oral-squamous-cell-carcinoma-via-immunohistochemical-methods
#15
Betina Chandolia, Jai Parkash Rajliwal, Manas Bajpai, Manika Arora
OBJECTIVE: To assess the prognostic potential for N-cadherin in oral squamous cell carcinoma and oral epithelial dysplasia. STUDY DESIGN: Across-sectional study, analytical study. PLACE AND DURATION OF STUDY: Maharishi Markandeshwar College of Dental Science Research (MMCDSR), Ambala, India, from 2011 to 2014. METHODOLOGY: Immunohistochemistry was used to observe the N-cadherin expression in 100 cases having epithelium with normal oral mucosa, oral epithelial dysplastic lesions and oral squamous cell carcinoma (OSCC)...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28903438/a-novel-prognostic-index-for-oral-squamous-cell-carcinoma-patients-with-surgically-treated
#16
Fa Chen, Yujie Cao, Jiangfeng Huang, Lingjun Yan, Lisong Lin, Fengqiong Liu, Fangping Liu, Junfeng Wu, Yu Qiu, Lin Cai, Baochang He
This study aims to develop an applicable prognostic index with conventional factors for predicting outcome of patients with oral squamous cell carcinoma (OSCC). We performed a prospective study in a large cohort of 892 OSCC patients in Fujian, China. All patients were randomly divided into a discovery group and validation group. A prognostic index was developed based on β value of each significant variable obtained from the multivariate Cox regression model. The results from discovery and validation set demonstrated thatthe model-4(included clinical stage, tumor differentiation, ill-fitting denture, oral hygiene and cigarette smoking) was the optimal model...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28893350/knockdown-of-gab1-inhibits-cellular-proliferation-migration-and-invasion-in-human-oral-squamous-carcinoma-cells
#17
Luyong Xu, Jie Li, Zheng Kuang, Yan Kuang, Hong Wu
Grb2-associated binder 1 (Gab1) is often aberrant in cancerous cells and tissues, whose alteration is to be responsiblefor aggressive phenotypes. In this study, we examined the Gab1 expression in human oral squamous cell carcinoma (OSCC) tissues and investigated the cellular and molecular effect of Gab1 on migration, invasion and cell growth of OSCC cell lines SCC15 and SCC25. We found Gab1 was over-expressed in OSCC tissues and cells, which is related to the protein levels of various molecules associated with cellular proliferation, migration, and invasion...
September 6, 2017: Oncology Research
https://www.readbyqxmd.com/read/28893045/estimation-of-serum-butyryl-cholinesterase-in-patients-with-oral-squamous-cell-carcinoma-a-cross-sectional-study
#18
Keerthi K Nair, Gujjar Vittobarao Pramod, Kanad Chaudhuri, Lingappa Ashok
INTRODUCTION: Oral cancer is a major global threat to public health. It is one of the most common causes of mortality and morbidity in the modern era. Oral Squamous Cell Carcinoma (OSCC) accounts for over 90% of the malignancies involving the oral cavity. The enzyme- Butyryl Cholinesterase (BChE) is proposed to have a role in cell proliferation, cell adhesion, cell differentiation, apoptosis and tumorigenesis. Few studies have been conducted for understanding the significance of serum BChE as a biomarker in oral cancer patients; however literature available is insufficient to arrive at a conclusion...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892665/difference-in-glycogen-metabolism-glycogen-synthesis-and-glycolysis-between-normal-and-dysplastic-malignant-oral-epithelium
#19
Hitoshi Aizawa, Shin-Ichi Yamada, Tiepeng Xiao, Tetsu Shimane, Kiyonori Hayashi, Fangfang Qi, Hirokazu Tanaka, Hiroshi Kurita
BACKGROUND: The purpose of this study was to investigate a difference in glycogen metabolism (glycogen synthesis and glycolysis) between the iodine stained (normal non-keartinized) and the unstained (dysplasctic/malignant) oral epithelium. METHODS: Twenty-one frozen tissue samples of iodine-stained and unstained mucosal tissue were obtained from 21 OSCC patients. Serial frozen sections were cut and examined with the hematoxylin-eosin and periodic acid-Schiff methods and immunohistochemical (IHC) staining for Ki67, P53, molecules associated with glycogenesis (i...
September 2, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28892050/carcinoembryonic-antigen-related-cell-adhesion-molecule-6-ceacam6-promotes-egf-receptor-signaling-of-oral-squamous-cell-carcinoma-metastasis-via-the-complex-n-glycosylation
#20
W-F Chiang, T-M Cheng, C-C Chang, S-H Pan, C A Changou, T-H Chang, K-H Lee, S-Y Wu, Y-F Chen, K-H Chuang, D-B Shieh, Y-L Chen, C-C Tu, W-L Tsui, M-H Wu
Aberrant protein glycosylation could be a distinct surface-marker of cancer cells that influences cancer progression and metastasis because glycosylation can regulate membrane protein folding which alters receptor activation and changes epitope exposure for antibody (Ab) recognition. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a glycophosphoinositol-anchored protein, is a heavily glycosylated tumor antigen. However, the clinical significance and biological effect of CEACAM6 glycosylation has not been addressed in cancers...
September 11, 2017: Oncogene
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