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Inflammation and Prostate Cancer

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https://www.readbyqxmd.com/read/28994721/natriuretic-peptides-the-case-of-prostate-cancer
#1
REVIEW
Letizia Mezzasoma, Matthew J Peirce, Alba Minelli, Ilaria Bellezza
Cardiac natriuretic peptides have long been known to act as main players in the homeostatic control of blood pressure, salt and water balance. However, in the last few decades, new properties have been ascribed to these hormones. A systematic review of English articles using MEDLINE Search terms included prostate cancer, inflammation, cardiac hormones, atrial natriuretic peptide, and brain natriuretic peptide. Most recent publications were selected. Natriuretic peptides are strongly connected to the immune system, whose two branches, innate and adaptive, are finely tuned and organized to kill invaders and repair injured tissues...
October 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28993831/association-of-snps-haplotypes-in-promoter-of-tnf-a-and-il-10-gene-together-with-life-style-factors-in-prostate-cancer-progression-in-indian-population
#2
Kapil Bandil, Pallavi Singhal, Atika Dogra, Sudhir K Rawal, D C Doval, Anil K Varshney, Mausumi Bharadwaj
OBJECTIVE: Levels of proinflammatory (TNF A) and anti-inflammatory (IL-10) cytokines play a key role in the progression of inflammation as well as cancer disease. We were investigating the potential association of single-nucleotide polymorphisms (SNPs)/haplotypes in proinflammatory (TNF A) and anti-inflammatory (IL-10) cytokines locus with the development of PCa in Indian population. MATERIALS AND METHODS: We had genotyped 235 BPH/PCa samples (130 BPH and 105 cancer) along with 115 control samples for proinflammatory (TNF A -238G/A and -308G/A) and anti-inflammatory (IL-10 -1082A/G, -819C/T and -592C/A) cytokines SNPs in the gene promoter region using ARMS-PCR method...
October 9, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28978344/the-expect-examining-exercise-prostate-cancer-and-circulating-tumour-cells-trial-study-protocol-for-a-randomised-controlled-trial
#3
Gráinne Sheill, Lauren Brady, Emer Guinan, Brian Hayes, Orla Casey, John Greene, Tatjana Vlajnic, Fidelma Cahill, Mieke Van Hemelrijck, Nicola Peat, Sarah Rudman, Juliette Hussey, Moya Cunningham, Liam Grogan, Thomas Lynch, Rustom P Manecksha, John McCaffrey, Lorelei Mucci, Orla Sheils, John O'Leary, Dearbhaile M O'Donnell, Ray McDermott, Stephen Finn
BACKGROUND: Prostate cancer (PrCa) is the second most common cancer in Ireland. Many men present with locally advanced or metastatic cancer for whom curative surgery is inappropriate. Advanced cancer patients are encouraged to remain physically active and therefore there is a need to investigate how patients with metastatic disease tolerate physical activity programmes. Physical activity reduces levels of systemic inflammatory mediators and so an aerobic exercise intervention may represent an accessible and cost-effective means of ameliorating the pro-inflammatory effects of obesity and subsequently decrease poor cancer-specific outcomes in this patient population...
October 4, 2017: Trials
https://www.readbyqxmd.com/read/28976337/incidental-tc-99m-methylene-diphosphonate-uptake-in-an-active-thyroid-nodule
#4
Derya Çayır, Mine Araz, Şafak Akın, Melia Karaköse, Erman Çakal
Tc-99m-methylene diphosphonate (MDP) whole body scintigraphy is the method of choice for detection of metastatic bone diseases. It is primarily used to help diagnose various bone-related conditions such as primary or metastatic cancer of the bone, location of bone inflammation, and fractures that may not be visible on traditional X-ray images, as well as detection of bone damage due to infections and other conditions. In addition, bone scanning is often used for the follow-up or evaluation of response to treatment in some malignancies like prostate and breast cancers...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28958833/cancer-risk-in-patients-with-beh%C3%A3-et-s-disease-a-nationwide-population-based-dynamic-cohort-study-from-korea
#5
Sae Jung Na, Min Ji Kang, Dong Soo Yu, Kyung-Do Han, Ji Hyun Lee, Yong Gyu Park, Young Bok Lee
BACKGROUND: Many studies have shown a link between inflammation and cancer development. However, there are few studies regarding the correlation between Behçet's disease (BD) and cancer. OBJECTIVES: To determine the overall cancer risk and risk of specific cancers in patients with BD. METHODS: BD patients (n = 14,137; mean age, 44.2 ± 12.5 years; male, 32.4%) without known previous cancer were selected from the Korean National Health Insurance Database between 2007 and 2014...
September 25, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28943900/influence-of-chronic-inflammation-on-bcl-2-and-pcna-expression-in-prostate-needle-biopsy-specimens
#6
Michael Glover, Shardul Soni, Qinghu Ren, Gregory T Maclennan, Pingfu Fu, Sanjay Gupta
The association between inflammation and cancer has been established in certain forms of human malignancies; however, its role in prostate cancer remains unclear. The present study investigates a possible association between chronic inflammation and the development of epithelial neoplasia in the prostate. Needle biopsy specimens were obtained from patients with serum prostate-specific antigen levels >4 ng/ml, evaluated for morphological findings, and immunostained for Bcl-2 and proliferating cell nuclear antigen (PCNA)...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28941222/nonsteroidal-anti-inflammatory-drugs-nsaids-and-prostate-cancer-risk-results-from-the-epicap-study
#7
Solene Doat, Sylvie Cénée, Brigitte Trétarre, Xavier Rebillard, Pierre-Jean Lamy, Jean-Pierre Bringer, François Iborra, Thibaut Murez, Marie Sanchez, Florence Menegaux
Chronic inflammation may play a role in prostate cancer carcinogenesis. In that context, our objective was to investigate the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in prostate cancer risk based on the EPICAP data. EPICAP is a population-based case-control study carried out in 2012-2013 (département of Hérault, France) that enrolled 819 men aged less than 75 years old newly diagnosed for prostate cancer and 879 controls frequency matched to the cases on age. Face to face interviews gathered information on several potential risk factors including NSAIDs use...
September 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28903065/inflammation-polymorphisms-and-prostate-cancer-risk-in-jamaican-men-role-of-obesity-body-size
#8
Bhawna Dubey, Maria Jackson, Charnita Zeigler-Johnson, Karthik Devarajan, Rafael E Flores-Obando, Norma McFarlane-Anderson, Marshall Tulloch-Reid, William Aiken, Kevin Kimbro, Dominique Jones, LaCreis R Kidd, Camille Ragin
African ancestry and obesity are associated with higher risk of prostate cancer (PC). In a pilot study, we explored interactions between obesity (as measured by waist to hip ratio (WHR)) and inflammatory SNPs in relation to PC risk among Jamaican men. This study evaluated 87 chemokine and cytokine associated SNPs in obese and normal weight cases (N=109) and controls (N=102) using a stepwise penalized logistic regression approach in multivariable analyses. Upon stratification by WHR (normal weight (WHR<0...
September 10, 2017: Gene
https://www.readbyqxmd.com/read/28878599/clinical-importance-of-histopathological-inflammation-in-patients-with-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-a-prospective-study-of-222-patients
#9
Thibault Meert, Evert Baten, Koenraad van Renterghem
OBJECTIVE: To investigate the relationship between the severity of histopathological prostatic inflammation with lower urinary tract symptoms and prostate specific antigen (PSA) levels. METHODS: We prospectively included 222 consecutive patients eligible for transurethral resection of the prostate in a non-academic referral center by a single surgeon. Patients with proven urinary tract infection or prostate cancer were excluded. Preoperative assessment included PSA levels, International Prostate Symptom Score (IPSS), mean peak flow, mean resected prostate weight and post-residual volume...
August 2017: Current Urology
https://www.readbyqxmd.com/read/28861306/the-predictive-value-of-platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratio-in-determining-urethral-stricture-after-transurethral-resection-of-prostate
#10
Murat Gül, Emre Altıntaş, Mehmet Kaynar, Muhammet Serdar Buğday, Serdar Göktaş
OBJECTIVE: The pathology of urethral stricture disease is still unclear however progressive inflammation may contribute to the development of urethral stricture. The platelet-to- lymphocyte ratio (PLR) is a new and simple marker that indicates inflammation. In this study we aimed to investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and PLR in patients with urethral stricture who underwent transurethral resection of prostate (TURP). MATERIAL AND METHODS: A total of 208 patients who underwent bipolar-TURP were included in this study...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28853678/hpv-related-squamous-cell-carcinoma-in-a-neovagina-after-male-to-female-gender-confirmation-surgery
#11
Jesús Bollo, Andrea Balla, Carlos Rodriguez Luppi, Carmen Martinez, Silvia Quaresima, Eduard M Targarona
Vaginoplasty by penile and scrotal skin inversion is a well-established technique for male-to-female gender confirmation surgery. In this setting, chronic inflammation and lacerations associated with history of human papillomavirus (HPV) infection may induce a high risk of malignant degeneration in the long term. A 78-year-old transgender woman was admitted with genital discomfort and neovaginal discharge. The patient's history revealed male-to-female gender confirmation surgery with construction of a neovagina by penile and scrotal skin inversion at 33 years of age...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28828356/relation-between-histological-prostatitis-and-lower-urinary-tract-symptoms-and-erectile-function
#12
Taiki Mizuno, Ippei Hiramatsu, Yusuke Aoki, Hirofumi Shimoyama, Taiji Nozaki, Masato Shirai, Yan Lu, Shigeo Horie, Akira Tsujimura
BACKGROUND: Chronic prostatitis (CP) significantly worsens a patient's quality of life (QOL), but its etiology is heterogeneous. Although the inflammatory process must be associated with CP symptoms, not all patients with benign prostatic hyperplasia and histological prostatitis complain of CP symptoms. The relation between the severity of histological inflammation and lower urinary tract symptoms (LUTS) and erectile function is not fully understood. METHODS: This study comprised 26 men with suspected prostate cancer but with no malignant lesion by pathological examination of prostate biopsy specimens...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28797714/profiling-the-urinary-microbiome-in-men-with-positive-versus-negative-biopsies-for-prostate-cancer
#13
Eva Shrestha, James R White, Shu-Han Yu, Ibrahim Kulac, Onur Ertunc, Angelo M De Marzo, Srinivasan Yegnasubramanian, Leslie A Mangold, Alan W Partin, Karen S Sfanos
PURPOSE: Studies demonstrating bacterial DNA and cultivable bacteria in urine samples have challenged the clinical dogma that urine is sterile. Furthermore, studies now indicate that dysbiosis of the urinary microbiome is associated with pathological conditions. We propose that the urinary microbiome may influence chronic inflammation observed in the prostate, leading to prostate cancer development and progression. Therefore, we profiled the urinary microbiome in men with positive vs negative biopsies for prostate cancer...
August 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28783760/total-glucosides-of-paeony-inhibits-lipopolysaccharide-induced-proliferation-migration-and-invasion-in-androgen-insensitive-prostate-cancer-cells
#14
Zhi-Hui Zhang, Dong-Dong Xie, Shen Xu, Mi-Zhen Xia, Zhi-Qiang Zhang, Hao Geng, Lei Chen, Da-Ming Wang, Wei Wei, De-Xin Yu, De-Xiang Xu
Previous studies demonstrated that inflammatory microenvironment promoted prostate cancer progression. This study investigated whether total glucosides of paeony (TGP), the active constituents extracted from the root of Paeonia Lactiflora Pall, suppressed lipopolysaccharide (LPS)-stimulated proliferation, migration and invasion in androgen insensitive prostate cancer cells. PC-3 cells were incubated with LPS (2.0 μg/mL) in the absence or presence of TGP (312.5 μg /mL). As expected, cells at S phase and nuclear CyclinD1, the markers of cell proliferation, were increased in LPS-stimulated PC-3 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28768237/annexin-a5-suppresses-cyclooxygenase-2-expression-by-downregulating-the-protein-kinase-c-%C3%AE-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway-in-prostatfe-cancer-cells
#15
Hyoung-Seok Baek, Nahee Park, Yeo-Jung Kwon, Dong-Jin Ye, Sangyun Shin, Young-Jin Chun
Annexin A5 (ANXA5) is a member of the annexin protein family. Previous studies have shown that ANXA5 is involved in anti-inflammation and cell death. However, the detailed mechanism of the role of ANXA5 in cancer cells is not well understood. In this study, we investigated the inhibitory effect of ANXA5 on cyclooxygenase-2 (COX-2) in prostate cancer cells. Expression of COX-2 induced by TNF-α was inhibited by overexpression of ANXA5 and inhibition of COX-2 expression by auranofin, which could induce ANXA5 expression, was restored by ANXA5 knockdown...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28754796/a-prospective-study-of-chronic-inflammation-in-benign-prostate-tissue-and-risk-of-prostate-cancer-linked-pcpt-and-select-cohorts
#16
Elizabeth A Platz, Ibrahim Kulac, John R Barber, Charles G Drake, Corinne E Joshu, William G Nelson, M Scott Lucia, Eric A Klein, Scott M Lippman, Howard L Parnes, Ian M Thompson, Phyllis J Goodman, Catherine M Tangen, Angelo M De Marzo
Background: We leveraged two trials to test the hypothesis of an inflammation-prostate cancer link prospectively in men without indication for biopsy.Methods: Prostate Cancer Prevention Trial (PCPT) participants who had an end-of-study biopsy performed per protocol that was negative for cancer and who subsequently enrolled in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) were eligible. We selected all 100 cases and sampled 200 frequency-matched controls and used PCPT end-of-study biopsies as "baseline...
October 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28753870/outcomes-of-prostate-specific-antigen-based-prostate-cancer-screening-among-men-using-nonsteroidal-anti-inflammatory-drugs
#17
Teemu Johannes Murtola, Arla M Vettenranta, Kirsi Talala, Kimmo Taari, Ulf-Håkan Stenman, Teuvo L J Tammela, Anssi Auvinen
BACKGROUND: The Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC), the largest component of the European Randomized Study of Screening for Prostate Cancer (ERSPC), showed a smaller, nonsignificant reduction in prostate cancer-specific mortality by systematic prostate-specific antigen (PSA)-based screening compared with the overall ERSPC results. Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce inflammation and also PSA elevations due to intraprostatic inflammation...
March 24, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753646/associations-between-self-reported-diabetes-and-78-circulating-markers-of-inflammation-immunity-and-metabolism-among-adults-in-the-united-states
#18
Alison L Van Dyke, Krystle A Lang Kuhs, Meredith S Shiels, Jill Koshiol, Britton Trabert, Erikka Loftfield, Mark P Purdue, Nicolas Wentzensen, Ruth M Pfeiffer, Hormuzd A Katki, Allan Hildesheim, Troy J Kemp, Ligia A Pinto, Anil K Chaturvedi, Mahboobeh Safaeian
Inflammation is increasingly thought to be associated with diabetes; however, only a few inflammation markers have been assessed concurrently in relation to history of diabetes. In the most comprehensive evaluation of inflammation markers and diabetes to date using a Luminex bead-based assay, we measured 78 inflammation-, immune-, and metabolic-related markers detectable in at least 10% of serum samples collected from participants from the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) screening trial (n = 1,814)...
2017: PloS One
https://www.readbyqxmd.com/read/28752333/significance-of-long-chain-polyunsaturated-fatty-acids-in-human-health
#19
REVIEW
Rafael Zárate, Nabil El Jaber-Vazdekis, Noemi Tejera, José A Pérez, Covadonga Rodríguez
In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease. Of particular interest is the study of omega-3 and omega-6 long chain polyunsaturated fatty acids (LC-PUFAs), notably EPA (eicosapentaenoic acid, 20:5n-3), DHA (docosahexaenoic acid, 22:6n-3), and ARA (arachidonic acid, 20:4n-6), and their transformation into bioactive lipid mediators...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28741687/a-distinct-plasma-lipid-signature-associated-with-poor-prognosis-in-castration-resistant-prostate-cancer
#20
Hui-Ming Lin, Kate L Mahon, Jacquelyn M Weir, Piyushkumar A Mundra, Calan Spielman, Karen Briscoe, Howard Gurney, Girish Mallesara, Gavin Marx, Martin R Stockler, PRIMe Consortium, Robert G Parton, Andrew J Hoy, Roger J Daly, Peter J Meikle, Lisa G Horvath
Lipids are known to influence tumour growth, inflammation and chemoresistance. However, the association of circulating lipids with the clinical outcome of metastatic castration-resistant prostate cancer (CRPC) is unknown. We investigated associations between the plasma lipidome and clinical outcome in CRPC. Lipidomic profiling by liquid chromatography-tandem mass spectrometry was performed on plasma samples from a Phase 1 discovery cohort of 96 CRPC patients. Results were validated in an independent Phase 2 cohort of 63 CRPC patients...
July 25, 2017: International Journal of Cancer. Journal International du Cancer
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