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Inflammation and Prostate Cancer

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https://www.readbyqxmd.com/read/29678446/cycloartane-type-sapogenol-derivatives-inhibit-nfb-activation-as-chemopreventive-strategy-for-inflammation-induced-prostate-carcinogenesis
#1
Bilge Debeleç-Bütüner, Mert Burak Öztürk, Özgür Tağ, İsmail Hakkı Akgün, Günay Yetik-Anacak, Erdal Bedir, Kemal Sami Korkmaz
Chronic inflammation is associated to 25% of cancer cases according to epidemiological data. Therefore, inhibition of inflammation-induced carcinogenesis can be an efficient therapeutic approach for cancer chemoprevention in drug development studies. It is also determined that anti-inflammatory drugs reduce cancer incidence. Cell culture-based in vitro screening methods are used as a fast and efficient method to investigate the biological activities of the biomolecules. In addition, saponins are molecules that are isolated from natural sources and are known to have potential for tumor inhibition...
April 17, 2018: Steroids
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#2
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29672311/inverse-association-of-prostatic-chronic-inflammation-among-prostate-cancer-tumor-grade-groups-retrospective-study-of-738-consecutive-cases-elected-to-a-first-random-biopsy-set
#3
Antonio Benito Porcaro, Alessandro Tafuri, Giovanni Novella, Marco Sebben, Arianna Mariotto, Davide Inverardi, Paolo Corsi, Tania Processali, Marco Pirozzi, Nelia Amigoni, Riccardo Rizzetto, Matteo Brunelli, Matteo Balzarro, Salvatore Siracusano, Walter Artibani
OBJECTIVES: The study aimed to evaluate associations of prostatic chronic inflammation (PCI) with prostate cancer (PCA) grade groups by the International Society of Urological Pathology (ISUP). METHODS: The study evaluated retrospectively 738 cases. The patient population was sampled into 3 groups collecting cases without and with PCA including subjects with lSUP grade group 1 and grade groups 2-5. RESULTS: PCI was assessed in 185 patients (25...
April 19, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29669727/geographic-differences-in-baseline-prostate-inflammation-and-relationship-with-subsequent-prostate-cancer-risk-results-from-the-multinational-reduce-trial
#4
Emma H Allott, Sarah C Markt, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Adriole, Lorelei A Mucci, Stephen J Freedland
BACKGROUND: Prostate cancer (PC) incidence rates vary 25-fold worldwide. Differences in PSA screening are largely, but not entirely, responsible. We examined geographic differences in prevalence of histologic prostate inflammation and subsequent PC risk. METHODS: 7,000 non-Hispanic white men were enrolled in the REDUCE trial from Europe (n=4,644), North America (n=1,746), South America (n=466), and Australia/New Zealand (n=144). Histologic inflammation in baseline negative prostate biopsies was classified as chronic (lymphocytes/macrophages) or acute (neutrophils)...
April 18, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29663110/neutrophil-lymphocyte-and-platelet-counts-and-risk-of-prostate-cancer-outcomes-in-white-and-black-men-results-from-the-search-database
#5
Adriana C Vidal, Lauren E Howard, Amanda de Hoedt, Matthew R Cooperberg, Christopher J Kane, William J Aronson, Martha K Terris, Christopher L Amling, Emanuela Taioli, Jay H Fowke, Stephen J Freedland
PURPOSE: Systemic inflammation, as measured by C-reactive protein, has been linked with poor prostate cancer (PC) outcomes, predominantly in white men. Whether other immune measures like white blood cell counts are correlated with PC progression and whether results vary by race is unknown. We examined whether complete blood count (CBC) parameters were associated with PC outcomes and whether these associations varied by race. METHODS: Analyses include 1,826 radical prostatectomy patients from six VA hospitals followed through medical record review for biochemical recurrence (BCR)...
April 17, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29661719/rectal-ulcer-and-pseudomalignant-epithelial-changes-after-prostate-seed-brachytherapy-a-rare-complication-with-a-diagnostic-pitfall
#6
Hwajeong Lee, Natallia Sheuka, Osama El-Kadi, Brian P Murray, Hugh A Fisher, Bhaskar V S Kallakury, Edward C Lee, Ann Boguniewicz, Timothy A Jennings
BACKGROUND: Implant brachytherapy (IBT) is a well-recognized treatment modality for early stage prostate cancer. Rectal ulcer and rectourethral fistula complicating IBT may cause an alteration of the normal anatomic landmarks. In this context, pseudomalignant radiation-induced changes within prostatic epithelium may be misinterpreted as a primary rectal malignancy. Such challenging and misleading findings have not been described, and may not be recognized as such. MATERIALS AND METHODS: We present the clinical and pathologic aspects of two patients who underwent IBT for low stage prostate cancer that was complicated by deep rectal ulcer...
April 4, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#7
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29620190/lncrnapcat29-inhibits-pulmonary-fibrosis-via-the-tgf%C3%A2-%C3%AE-1%C3%A2-regulated-rasal1-erk1-2-signal-pathway
#8
Xiaoming Liu, Shanyu Gao, Huile Xu
Pulmonary fibrosis is a severe respiratory disease characterized by the aggregation of extracellular matrix components and inflammation‑associated injury. Studies have suggested that long non‑coding RNAs (lncRNA) may serve a role in the pathophysiological processes of pulmonary fibrosis. However, the potential molecular mechanisms involving the lncRNA, prostate cancer‑associated transcript 29 (lncRNAPCAT29) in the progression of pulmonary fibrosis are yet to be determined. In the present study, the role of lncRNAPCAT29 and the potential signaling mechanism in pulmonary fibrosis progression was investigated...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29617729/statin-use-linked-with-a-decrease-in-the-conversion-from-high-grade-prostatic-intraepithelial-neoplasia-hgpin-to-prostate-cancer
#9
Jay H Fowke, Saundra S Motley
The roles of obesity, metabolic dysregulation, and systemic inflammation to advance prostate carcinogenesis are unclear. This study investigates metabolic and inflammatory factors in the transition from high-grade prostatic intraepithelial neoplasia (HGPIN) to prostate cancer (PC). We prospectively followed 160 men diagnosed with HGPIN at biopsy, and therefore at high-risk and clinically monitored for PC. Analyses investigated body mass index (BMI), waist circumference, waist-hip ratio, height, fat mass, lean mass % body fat, NSAIDs, statins, metformin, diabetes, hypertension, hypercholesterolemia representing metabolic dysregulation on the risk of a PC diagnosis during follow-up...
April 3, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29599304/aspirin-in-the-management-of-patients-with-prostate-cancer-undergoing-radiotherapy-friend-or-foe
#10
REVIEW
Bianca Mascan, Laure Marignol
Aspirin has cyclooxygenase-2 (COX2)-mediated anti-inflammatory and anti-coagulant properties that may confer a positive effect in preventing and limiting the progression of prostate cancer. Prostate cancer has been shown to have poor treatment outcomes due to therapeutic resistance; therefore, COX2 inhibition caused by aspirin could represent an opportunity to augment current therapies. This is particularly of interest to patients undergoing radiation therapy (RT) where inflammation is a common side-effect...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29594819/prospective-evaluation-of-serum-il-16-and-risk-of-prostate-cancer-in-the-prostate-lung-colorectal-and-ovarian-cancer-screening-trial
#11
Amy Moore, Wen-Yi Huang, Kim Danforth, Roni Falk, Allison Meade, Rachel Bagni, Sonja I Berndt
BACKGROUND: Sexually transmitted infections and chronic inflammation have been associated with an increased risk of prostate cancer. Inflammatory mediators, such as cytokines and free radicals, have been hypothesized to play a role. METHODS: To explore the role of inflammation in prostate cancer risk further, we examined the association between pre-diagnostic serum levels of interleukin-16 (IL-16), an important pleiotropic cytokine, and prostate cancer risk among 932 Caucasian cases and 942 controls and 154 African-American cases and 302 controls in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial...
March 28, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29593467/associations-of-transitional-zone-volume-with-intraprostatic-chronic-inflammation-and-prostate-cancer-risk-in-patients-undergoing-a-first-random-biopsy-set
#12
Antonio B Porcaro, Daniele Mattevi, Giovanni Novella, Nicolò De Luyk, Paolo Corsi, Leonardo Bizzotto, Davide De Marchi, Marco Sebben, Alessandro Tafuri, Davide Inverardi, Tania Processali, Maria A Cerruto, Matteo Brunelli, Salvatore Siracusano, Walter Artibani
Objectives: To investigate associations of the transitional zone volume (TZV) with intraprostatic chronic inflammatory infiltrate (CII) and prostate cancer (PCa) risk in patients undergoing a first random biopsy set. Materials and Methods: The study included a homogenous population of 596 patients. The volume of the prostate and TZV were separately measured. Independent associations were investigated by multivariate logistic regression analysis. Results: The median TZV was 18 ml, CII was detected in 157 cases (26...
February 2018: Current Urology
https://www.readbyqxmd.com/read/29588543/urinary-ce-ms-peptide-marker-pattern-for-detection-of-solid-tumors
#13
Iwona Belczacka, Agnieszka Latosinska, Justyna Siwy, Jochen Metzger, Axel S Merseburger, Harald Mischak, Antonia Vlahou, Maria Frantzi, Vera Jankowski
Urinary profiling datasets, previously acquired by capillary electrophoresis coupled to mass-spectrometry were investigated to identify a general urinary marker pattern for detection of solid tumors by targeting common systemic events associated with tumor-related inflammation. A total of 2,055 urinary profiles were analyzed, derived from a) a cancer group of patients (n = 969) with bladder, prostate, and pancreatic cancers, renal cell carcinoma, and cholangiocarcinoma and b) a control group of patients with benign diseases (n = 556), inflammatory diseases (n = 199) and healthy individuals (n = 331)...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29588305/appendicitis-before-age-20-years-is-associated-with-an-increased-risk-of-later-prostate-cancer
#14
Henrik Ugge, Ruzan Udumyan, Jessica Carlsson, Sabina Davidsson, Ove Andrén, Scott Montgomery, Katja Fall
BACKGROUND: Appendicitis before age 20 years has been observed to influence the risk of several inflammatory conditions, possibly through underlying immunological mechanisms. Inflammation has further been suggested to be involved in prostate cancer development. We therefore hypothesized that immunological characteristics signaled by appendicitis before late adolescence might influence the risk of later prostate cancer, and aimed to evaluate this association in a population-based study...
March 27, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29578426/dysfunction-of-various-organ-systems-induced-by-sepsis-with-underlying-severe-myelomic-diseases-and-prostate-cancer-case-report
#15
L Ratiani, N Intskirveli, L Goliadze, T Chkhikvadze, L Koptonashvili, E Khuchua
A 65-year-old male patient, unconscious, was admitted into the clinic by the Ambulance. From the patient's medical history it was revealed that several hours before the admission in the clinic the following symptoms were present: shortness of breath, fever, hypotonia, consciousness inhibition, because of which emergency brigade was called and was brought by the Emergency Brigade. The history is loaded by chronic pathologies: myeloma disease, prostate cancer, ciliary arrhythmia, heart failure; received several courses of polichemotherapy, last ten days has been treated for pneumonia with antibiotics of ceftriaxone group in outpatient setting...
February 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29577437/oral-administration-of-cernitin-pollen-extract-cernilton-%C3%A2-for-30-days-might-be-useful-to-avoid-unnecessary-biopsy-in-prostate-biopsy-candidates-a-preliminary-study
#16
Yoshikazu Togo, Daishi Ichioka, Jun Miyazaki, Yoshiko Maeda, Koji Kameyama, Mitsuru Yasuda, Yoshiki Hiyama, Satoshi Takahashi, Hiroshi Nagae, Seiichi Hirota, Shingo Yamamoto
OBJECTIVES: To assess the effect of cernitin pollen extract on serum prostate-specific antigen level prostate biopsy candidates, and to develop an ideal protocol to avoid an unnecessary biopsy procedure. METHODS: A total of 61 patients were administrated cernitin pollen extract tablets (two tablets t.i.d.) for 30 days, and then underwent a prostate biopsy with ≥12 systematic and targeted biopsy cores obtained. Serum prostate-specific antigen levels were examined before and after administration of the pollen extract, and the change in serum prostate-specific antigen and the rate of change were analyzed in relation to negative and positive biopsy results for cancer...
March 25, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29574020/sirt1-and-micrornas-the-role-in-breast-lung-and-prostate-cancers
#17
REVIEW
Hedyieh Karbasforooshan, Ali Roohbakhsh, Gholamreza Karimi
Breast cancer and prostate cancer are the most common malignant tumors in female and men, respectively. Furthermore, lung cancer is the leading cause of cancer deaths worldwide. It is an emergency to develop a powerful strategy to treat these threatening cancers more effectively, because of low efficacy and high rates of chemotherapy effects. MicroRNAs (miRNAs), a class of small non-coding RNAs, are key regulators of gene expression via induction of translational repression or mRNA degradation. MiRNA deregulation has been linked to cancer initiation and progression...
March 21, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29573216/glucose-impairments-and-insulin-resistance-in-prostate-cancer-the-role-of-obesity-nutrition-and-exercise
#18
REVIEW
K M Di Sebastiano, J H Pinthus, W C M Duivenvoorden, M Mourtzakis
BACKGROUND: Hyperinsulinemia, obesity and related metabolic diseases are associated with prostate cancer development. Prostate cancer patients undergoing androgen deprivation therapy (ADT) are at increased risk for metabolic syndrome, cardiovascular disease and diabetes, while pre-existing metabolic conditions may be exacerbated. PURPOSE: An integrative approach is used to describe the interactions between insulin, glucose metabolism, obesity and prostate cancer...
March 24, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29558443/the-complex-interplay-between-chronic-inflammation-the-microbiome-and-cancer-understanding-disease-progression-and-what-we-can-do-to-prevent-it
#19
REVIEW
Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk, Eytan Wine
Cancer is a multifaceted condition, in which a senescent cell begins dividing in an irregular manner due to various factors such as DNA damage, growth factors and inflammation. Inflammation is not typically discussed as carcinogenic; however, a significant percentage of cancers arise from chronic microbial infections and damage brought on by chronic inflammation. A hallmark cancer-inducing microbe is Helicobacter pylori and its causation of peptic ulcers and potentially gastric cancer. This review discusses the recent developments in understanding microbes in health and disease and their potential role in the progression of cancer...
March 20, 2018: Cancers
https://www.readbyqxmd.com/read/29545399/specificity-protein-transcription-factors-and-cancer-opportunities-for-drug-development
#20
Stephen Safe, James L Abbruzzese, Maen Abdelrahim, Erik Hedrick
Specificity protein (Sp) transcription factors (TFs) such as Sp1 are critical for early development but their expression decreases with age and there is evidence that transformation of normal cells to cancer cells is associated with upregulation of Sp1, Sp3 and Sp4 which are highly expressed in cancer cells and tumors. Sp1 is a negative prognostic factor for pancreatic, colon, glioma, gastric, breast, prostate, and lung cancer patients. Functional studies also demonstrate that Sp TFs regulate genes responsible for cancer cell growth, survival, migration/invasion, inflammation and drug resistance, and Sp1, Sp3 and Sp4 are also non-oncogene addiction (NOA) genes and important drug targets...
March 15, 2018: Cancer Prevention Research
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