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JOURNAL ARTICLE
Evangelos Dadiotis, Vangelis Mitsis, Eleni Melliou, Prokopios Magiatis
The widespread use of phytocannabinoids or cannabis extracts as ingredients in numerous types of products, in combination with the legal restrictions on THC content, has created a need for the development of new, rapid, and universal analytical methods for their quantitation that ideally could be applied without separation and standards. Based on previously described qNMR studies, we developed an expanded 1 H qNMR method and a novel 2D-COSY qNMR method for the rapid quantitation of ten major phytocannabinoids in cannabis plant extracts and cannabis-based products...
May 5, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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JOURNAL ARTICLE
Madeline G Roman, Ya-Chih Cheng, Sarah Kerrigan, Rachel Houston
The Controlled Substances Act (CSA) classifies marijuana (Cannabis sativa) as a Schedule I illicit drug. However, the recent Agriculture Improvement Act of 2018 (U.S. Farm Bill) removed hemp from the definition of marijuana in the CSA, making it a legal crop. As a result, many hemp products are now available, including strains of hemp buds high in other cannabinoids such as cannabidiol (CBD) or cannabigerol (CBG). The genetic inheritance of chemical phenotype (chemotype) has been widely studied, with the tetrahydrocannabinolic acid (THCA) synthase gene at the forefront...
July 2022: Journal of Forensic Sciences
#23
REVIEW
Justine Ting, Anna Garnett, Lorie Donelle
AIM: This integrative review aimed to synthesize evidence pertaining to interventions that have been used to facilitate nurse education and training on electronic health records. BACKGROUND: Inadequate education and training can threaten the adoption of electronic health records and negatively impact the quality of nursing documentation. A review of the literature may help facilitate the development of evidence-based interventions for nursing education and training on electronic health records...
August 6, 2021: Nurse Education in Practice
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JOURNAL ARTICLE
Lyndsey L Anderson, Adam Ametovski, Jia Lin Luo, Declan Everett-Morgan, Iain S McGregor, Samuel D Banister, Jonathon C Arnold
Cannabis-based products are increasingly being used to treat refractory childhood epilepsies such as Dravet syndrome. Cannabis contains at least 140 terpenophenolic compounds known as phytocannabinoids. These include the known anticonvulsant compound cannabidiol (CBD) and several molecules showing emergent anticonvulsant properties in animal models. Cannabichromene (CBC) is a phytocannabinoid frequently detected in artisanal cannabis oils used in the community by childhood epilepsy patients. Here we examined the brain and plasma pharmacokinetic profiles of CBC, cannabichromenic acid (CBCA), cannabichromevarin (CBCV), and cannabichromevarinic acid (CBCVA) following intraperitoneal administration in mice...
January 20, 2021: ACS Chemical Neuroscience
#25
JOURNAL ARTICLE
Tao Jiang, Do-Hyun Nam, Zvi Ram, Wai-Sang Poon, Jiguang Wang, Damdindorj Boldbaatar, Ying Mao, Wenbin Ma, Qing Mao, Yongping You, Chuanlu Jiang, Xuejun Yang, Chunsheng Kang, Xiaoguang Qiu, Wenbin Li, Shaowu Li, Ling Chen, Xuejun Li, Zhixiong Liu, Weimin Wang, Hongmin Bai, Yu Yao, Shouwei Li, Anhua Wu, Ke Sai, Guilin Li, Kun Yao, Xinting Wei, Xianzhi Liu, Zhiwen Zhang, Yiwu Dai, Shengqing Lv, Liang Wang, Zhixiong Lin, Jun Dong, Guozheng Xu, Xiaodong Ma, Wei Zhang, Chuanbao Zhang, Baoshi Chen, Gan You, Yongzhi Wang, Yinyan Wang, Zhaoshi Bao, Pei Yang, Xing Fan, Xing Liu, Zheng Zhao, Zheng Wang, Yiming Li, Zhiliang Wang, Guanzhang Li, Shengyu Fang, Lianwang Li, Yanwei Liu, Shuai Liu, Xia Shan, Yuqing Liu, Ruichao Chai, Huimin Hu, Jing Chen, Wei Yan, Jinquan Cai, Hongjun Wang, Lingchao Chen, Yuan Yang, Yu Wang, Lei Han, Qixue Wang
To follow the revision of the fourth edition of WHO classification and the recent progress on the management of diffuse gliomas, the joint guideline committee of Chinese Glioma Cooperative Group (CGCG), Society for Neuro-Oncology of China (SNO-China) and Chinese Brain Cancer Association (CBCA) updated the clinical practice guideline. It provides recommendations for diagnostic and management decisions, and for limiting unnecessary treatments and cost. The recommendations focus on molecular and pathological diagnostics, and the main treatment modalities of surgery, radiotherapy, and chemotherapy...
February 28, 2021: Cancer Letters
#26
JOURNAL ARTICLE
Jonas Schemmel, Tina Steinhagen, Matthias Ziegler, Renate Volbert
We investigated how information on a motive to lie impacts on the perceived content quality of a statement and its subsequent veracity rating. In an online study, 300 participants rated a statement about an alleged sexual harassment on a scale based on Criteria-based Content Analysis (CBCA) and judged its veracity. In a 3 × 3 between-subjects design, we varied prior information (motive to lie, no motive to lie, and no information on a motive), and presented three different statement versions of varying content quality (high, medium, and low)...
2020: Frontiers in Psychology
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JOURNAL ARTICLE
Maria Galletta, Tristan A Reekie, Gayathri Nagalingam, Amy L Bottomley, Elizabeth J Harry, Michael Kassiou, James A Triccas
Methicillin-resistant Staphylococcus aureus (MRSA) has proven to be an imminent threat to public health, intensifying the need for novel therapeutics. Previous evidence suggests that cannabinoids harbour potent antibacterial activity. In this study, a group of previously inaccessible phytocannabinoids and synthetic analogues were examined for potential antibacterial activity. The minimum inhibitory concentrations and dynamics of bacterial inhibition, determined through resazurin reduction and time-kill assays, revealed the potent antibacterial activity of the phytocannabinoids against gram-positive antibiotic-resistant bacterial species, including MRSA...
August 16, 2020: Antibiotics
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JOURNAL ARTICLE
Welmoed K van Deen, Alexandra Obremskey, Graham Moore, M Elske van den Akker-van Marle, Jason N Doctor, Caroline Hwang
PURPOSE: Inflammatory bowel disease (IBD) patients experience diverse symptoms and the impact of these different symptoms varies substantially. Current disease activity measures do not account for the relative importance of the different symptoms and severity levels. In this study, we aimed to quantify the relative importance of different symptoms for IBD patients and to develop a patient preference-weighted symptom (PWS) score to assess symptom burden in IBD. METHODS: We performed a choice-based conjoint analysis (CBCA) survey with 129 IBD patients to estimate the relative importance of four common IBD symptoms: stool frequency, abdominal pain, blood in stools, and urgency...
August 19, 2020: Quality of Life Research
#29
JOURNAL ARTICLE
Michael D Kleinhenz, Geraldine Magnin, Zhoumeng Lin, Jason Griffin, Katie E Kleinhenz, Shawnee Montgomery, Andrew Curtis, Miriam Martin, Johann F Coetzee
Cannabinoid production for medicinal purposes has renewed interest in utilizing byproducts of industrial hemp (IH) as a feed source for livestock. However, the presence of bioactive residues in animal tissues may pose a risk to consumers. The purpose of this study was to characterize the plasma pharmacokinetics (PK) of cannabinoids and their metabolites in cattle after a single oral exposure to IH. Eight castrated male Holstein calves received a single oral dose of 35 g of IH to achieve a target dose of 5...
July 29, 2020: Scientific Reports
#30
JOURNAL ARTICLE
Binbin Li, Weiping Jie, Huiying He
Objective: Salivary rare basaloid lesions, including cribriform type basal cell adenoma (cBCA), BCA with incomplete capsule (iBCA), sialoblastoma (SB), and intercalated duct hyperplasia (IDH), could easily be misdiagnosed as adenoid cystic carcinoma (AdCC). We aim to identify an approach for differential diagnosis and to establish an optimal workflow concerning the diagnosis of these lesions. Material and methods: A panel of antibodies (MYB, β-catenin, CD117, SOX10, ki67, P63, calponin) and fluorescence in situ hybridization (FISH)-MYB were utilized to distinguish above salivary basaloid diseases from AdCC...
2020: Frontiers in Oncology
#31
REVIEW
Nicole L Stone, Alexandra J Murphy, Timothy J England, Saoirse E O'Sullivan
Embase and PubMed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, apart from cannabidiol and Δ9 -tetrahydrocannabinol, including Δ9 -tetrahydrocannabinolic acid, Δ9 -tetrahydrocannabivarin, cannabidiolic acid, cannabidivarin, cannabichromene, cannabichromenic acid, cannabichromevarin, cannabigerol, cannabigerolic acid, cannabigerivarin, cannabigerovarinic acid, cannabichromevarinic acid, cannabidivarinic acid, and cannabinol. Out of 2,341 studies, 31 articles met inclusion criteria...
October 2020: British Journal of Pharmacology
#32
JOURNAL ARTICLE
Ana Alberca-Páramo, Esther Pilar García-Santos, David Padilla-Valverde, Pedro Villarejo-Campos, Mercedes Estaire-Gómez, Jesús Martín Fernández
Introduction: Duplicity of the common bile duct (BCBD) is an unusual congenital disorder. Case report: A 80-year-old woman with duplication of the common bile duct with retrograde endoscopic cholangiopancreatography (ERCP) who did not resolve the symptoms. Discussion: Our case is a variant of type IV to the classification of DCBC. The MR cholangiography and presurgical ERCP allows assessment of the bile ducts, their caliber, and assessment of abnormalities...
2020: Cirugia y Cirujanos
#33
JOURNAL ARTICLE
Luca Giupponi, Valeria Leoni, Radmila Pavlovic, Annamaria Giorgi
The phytochemical profiling of hemp inflorescences of clonal plants growing in different conditions related to altitude was investigated. Four strains of industrial hemp ( Cannabis sativa L., family Cannabaceae) of Kompolti variety were selected and cloned to provide genetically uniform material for analyses of secondary metabolites (terpenes, cannabinoids, and flavonoids) at two different elevations: mountain (Alagna Valsesia 1200 m ASL) and plains (Vercelli Province 130 m ASL). Environmental conditions influenced by elevation have proven to be important factors inducing variations in hemp inflorescences' secondary metabolite composition...
March 18, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#34
JOURNAL ARTICLE
Lyndsey L Anderson, Ivan K Low, Samuel D Banister, Iain S McGregor, Jonathon C Arnold
Cannabis sativa produces a complex mixture of many bioactive molecules including terpenophenolic compounds known as phytocannabinoids. Phytocannabinoids come in neutral forms (e.g., Δ9 -tetrahydrocannabinol, THC; cannabidiol, CBD; etc.) or as acid precursors, which are dominant in the plant (e.g., Δ9 -tetrahydrocannabinolic acid, THCA; cannabidiolic acid, CBDA; etc.). There is increasing interest in unlocking the therapeutic applications of the phytocannabinoid acids; however, the present understanding of the basic pharmacology of phytocannabinoid acids is limited...
November 22, 2019: Journal of Natural Products
#35
JOURNAL ARTICLE
Duc-Cuong Bui, Jung-Eun Kim, Jiyoung Shin, Jae Yun Lim, Gyung Ja Choi, Yin-Won Lee, Jeong-Ah Seo, Hokyoung Son
Arsenite-resistance protein 2 (Ars2) is an important nuclear protein involved in various RNA metabolisms in animals and plants, but no Ars2 ortholog has been studied in filamentous fungi. Although it is an essential gene in most model eukaryotes, FgARS2 null mutants were viable in the plant pathogenic fungus Fusarium graminearum . The deletion of FgARS2 resulted in pleiotropic defects in various fungal developmental processes. Fgars2 mutants were irregular in nuclear division, and conidial germination was significantly retarded, causing the fungus to manifest its hypersensitive phenotypes under DNA damage stress...
2019: Frontiers in Microbiology
#36
JOURNAL ARTICLE
Huaizhe Yu, Tibor Szilvási, Kunlun Wang, Jake I Gold, Nanqi Bao, Robert J Twieg, Manos Mavrikakis, Nicholas L Abbott
Elementary reaction steps, including adsorption and dissociation, of a range of molecular adsorbates on transition metal sur-faces have been elucidated in the context of chemical catalysis. Here we leverage this knowledge to design liquid crystals (LCs) supported on ultrathin polycrystalline gold films (predominant crystallographic face is (111)) that are triggered to undergo ori-entational transitions by dissociative adsorption and dehydrogenation reactions involving chlorine and carboxylic acids, re-spectively, thus amplifying these atomic-scale surface processes in situ into macroscopic optical signals...
September 11, 2019: Journal of the American Chemical Society
#37
JOURNAL ARTICLE
Patricia Charlton, Shelley Doucet, Rima Azar, Daniel A Nagel, Leah Boulos, Alison Luke, Kim Mears, Katherine J Kelly, William J Montelpare
INTRODUCTION: The environmental scan has been described as an important tool to inform decision-making on policy, planning and programme development in the healthcare sector. Despite the wide adoption of environmental scans, there is no consensus on a working definition within the health services delivery context and methodological guidance on the design and implementation of this approach is lacking in the literature. The objectives of this study are to map the extent, range and nature of evidence that describe the definitions, characteristics, conceptualisations, theoretical underpinnings, study limitations and other features of the environmental scan in the health services delivery literature and to propose a working definition specific to this context...
September 6, 2019: BMJ Open
#38
JOURNAL ARTICLE
Richard Wood, Daniel D Moran, João F D Rodrigues, Konstantin Stadler
The UNFCCC requires the annual reporting of greenhouse gas emissions. These inventories focus on emissions within a territory, and do not capture the effect of emissions embodied in imports. Consumption based carbon accounting (CBCA) has been proposed as a complementary method to capture these emissions, and a number of global models have been developed to operationalise CBCA. However, discrepancies in country-level CBCA results occur, which can cause concern for the practical use of CBCA. Despite these quantitative difference in results, do they provide robust results when changes over time are investigated? Here we present results of all the major global models and normalise the model results by looking at changes over time relative to a common base year value...
June 24, 2019: Scientific Data
#39
JOURNAL ARTICLE
The Impact of Canadian School Food Programs on Children's Nutrition and Health: A Systematic Review.
Paige Colley, Bronia Myer, Jamie Seabrook, Jason Gilliland
The quality of children's diets has declined over the past few decades, giving rise to a variety of health-related consequences. In response to this trend, school food programs have become an increasingly effective method to support nutrition and lifelong healthy eating habits. This systematic review synthesizes current academic literature pertaining to school nutrition programs in Canada to identify existing interventions and their impacts on children's nutritional knowledge, dietary behaviour, and food intake...
November 15, 2018: Canadian Journal of Dietetic Practice and Research
#40
JOURNAL ARTICLE
Kaitlin U Laverty, Jake M Stout, Mitchell J Sullivan, Hardik Shah, Navdeep Gill, Larry Holbrook, Gintaras Deikus, Robert Sebra, Timothy R Hughes, Jonathan E Page, Harm van Bakel
Cannabis sativa is widely cultivated for medicinal, food, industrial, and recreational use, but much remains unknown regarding its genetics, including the molecular determinants of cannabinoid content. Here, we describe a combined physical and genetic map derived from a cross between the drug-type strain Purple Kush and the hemp variety "Finola." The map reveals that cannabinoid biosynthesis genes are generally unlinked but that aromatic prenyltransferase ( AP ), which produces the substrate for THCA and CBDA synthases (THCAS and CBDAS), is tightly linked to a known marker for total cannabinoid content...
January 2019: Genome Research
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