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JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#22
JOURNAL ARTICLE
Li-Da Chen, Ze-Rong Huang, Hong Yang, Mei-Qing Cheng, Hang-Tong Hu, Xiao-Zhou Lu, Ming-De Li, Rui-Fang Lu, Dan-Ni He, Peng Lin, Qiu-Ping Ma, Hui Huang, Si-Min Ruan, Wei-Ping Ke, Bing Liao, Bi-Hui Zhong, Jie Ren, Ming-De Lu, Xiao-Yan Xie, Wei Wang
Background Noninvasive tests can be used to screen patients with chronic liver disease for advanced liver fibrosis; however, the use of single tests may not be adequate. Purpose To construct sequential clinical algorithms that include a US deep learning (DL) model and compare their ability to predict advanced liver fibrosis with that of other noninvasive tests. Materials and Methods This retrospective study included adult patients with a history of chronic liver disease or unexplained abnormal liver function test results who underwent B-mode US of the liver between January 2014 and September 2022 at three health care facilities...
April 2024: Radiology
#23
JOURNAL ARTICLE
Namitha Jain, Yihsin Tai, Caterina Wilson, Elsa C Granato, Carlos Esquivel, Anthony Tsao, Fatima T Husain
PURPOSE: Military-affiliated individuals (MIs) are at a higher risk of developing hearing loss and tinnitus. While these disorders are well-studied in MIs, their impact relative to non-military-affiliated individuals (non-MIs) remains understudied. Our study compared hearing, speech-in-noise (SIN) perception, and tinnitus characteristics between MIs and non-MIs. METHOD: MIs ( n = 84) and non-MIs ( n = 193) underwent hearing threshold assessment and Quick Speech-in-Noise Test...
April 23, 2024: American Journal of Audiology
#24
JOURNAL ARTICLE
M Parzer, T Schmid, F Garmroudi, A Riss, T Mori, E Bauer
In this work, a measurement setup to study the Seebeck and Nernst effect at high temperatures and high magnetic fields is introduced and discussed. The measurement system allows for simultaneous measurements of both thermoelectric effects up to 700 K and magnetic fields up to 12 T. Based on theoretical concepts, measurement equations are derived that counteract constant spurious offset voltages and, therefore, inhibit systematic errors in the measurement setup. The functionality is demonstrated on polycrystalline samples of elemental bismuth as well as various full-Heusler materials, exhibiting an anomalous Nernst effect...
April 1, 2024: Review of Scientific Instruments
#25
JOURNAL ARTICLE
Yan Liu, Yu Han, Yuqi Gao, Nan Yao, Yuxiang Wang, Fengdan Wang, Zibo Wu, Yibo Dong, Sizhe Wang, Bo Li
Background : Frailty has been one of the most serious global public health challenges we will ever face. Oxidative stress is associated with the pathogenesis of frailty, and may be accurately reflected by the oxidative balance score (OBS). However, there have been no studies examining the effect of OBS on frailty. Therefore, we aimed to explore the association between OBS and frailty and whether there was an interaction between the outcomes. Methods : 22 914 participants aged over 20 years taking part in the National Health and Nutrition Examination Survey (NHANES) in 2007-2018 were involved in the study...
April 23, 2024: Food & Function
#26
JOURNAL ARTICLE
Xinghua Cai, Ping Yi, Xuewen Chen, Junhua Wu, Ganqiu Lan, Shijian Li, Shasha Luo, Fengdie Huang, Jinrong Huang, Peihong Shen
UNLABELLED: Acquired immunity is an important way to construct the intestinal immune barrier in mammals, which is almost dependent on suckling. To develop a new strategy for accelerating the construction of gut microbiome, newborn Holstein calves were continuously fed with 40 mL of compound probiotics (containing Lactobacillus plantarum T-14, Enterococcus faecium T-11, Saccharomyces cerevisiae T-209, and Bacillus licheniformis T-231) per day for 60 days. Through diarrhea rate monitoring, immune index testing, antioxidant capacity detection, and metagenome sequencing, the changes in diarrhea incidence, average daily gain, immune index, and gut microbiome of newborn calves within 60 days were investigated...
April 23, 2024: Microbiology Spectrum
#27
JOURNAL ARTICLE
Marija Vukojević, Nenad Vukojevic, Ante Vuković, Borna Rupčić, Mislav Blažević, Ante Blažević
Vogt-Koyanagi-Harada (VKH) disease is a multisystem disorder characterized by bilateral granulomatous panuveitis resulting in serous retinal detachments, disk edema, and a sunset glow fundus development. Furthermore, it is associated with various extraocular findings, such as tinnitus, hearing loss, vertigo, poliosis, and vitiligo (1). VKH is considered to be an autoimmune disease mediated by T-cells targeting melanocyte antigen tyrosinase peptide (2). Moreover, VKH more often occurs in individuals with a genetic predisposition to the disease, including those of Asian and Hispanic heritage (3)...
December 2023: Acta Dermatovenerologica Croatica: ADC
#28
JOURNAL ARTICLE
Anne T Berg, Christopher H Thompson, Leah Schust Myers, Erica Anderson, Lindsey Evans, Ariela J E Kaiser, Katherine Paltell, Amanda N Nili, Jean-Marc DeKeyser, Tatiana V Abramova, Gerry Nesbitt, Shawn Egan, Carlos G Vanoye, Alfred L George
SCN2A-related disorders secondary to altered function in the voltage-gated sodium channel NaV1.2 are rare with clinically heterogeneous expressions that include epilepsy, autism, and multiple severe to profound impairments and other conditions. To advance understanding of the clinical phenotypes and their relation to channel function, 81 patients (36, 44% female, median age 5.4 years) with 69 unique SCN2A variants were systematically phenotyped and their NaV1.2 channel function systematically assessed. Participants were recruited through the FamileSCN2A Foundation...
April 23, 2024: Brain
#29
JOURNAL ARTICLE
Matthew Chan, Toon Verstraelen, Alireza Tehrani, Michelle Richer, Xiaotian Derrick Yang, Taewon David Kim, Esteban Vöhringer-Martinez, Farnaz Heidar-Zadeh, Paul W Ayers
HORTON is a free and open-source electronic-structure package written primarily in Python 3 with some underlying C++ components. While HORTON's development has been mainly directed by the research interests of its leading contributing groups, it is designed to be easily modified, extended, and used by other developers of quantum chemistry methods or post-processing techniques. Most importantly, HORTON adheres to modern principles of software development, including modularity, readability, flexibility, comprehensive documentation, automatic testing, version control, and quality-assurance protocols...
April 28, 2024: Journal of Chemical Physics
#30
JOURNAL ARTICLE
Xinyue Shi, Minghui Xie, Kaiwen Yang, Yutao Niu, Haibin Ma, Yiming Zhu, Jiayi Li, Tingting Pan, Xiaoyan Zhou, Yujie Cui, Zhao Li, Yifu Yu, Xiaohua Yu, Jiwei Ma, Hongfei Cheng
Electrocatalytic reduction of nitrate to ammonia provides a green alternate to the Haber-Bosch method, yet it suffers from sluggish kinetics and a low yield rate. The nitrate reduction follows a tandem reaction of nitrate reduction to nitrite and subsequent nitrite hydrogenation to generate ammonia, and the ammonia Faraday efficiency (FE) is limited by the competitive hydrogen evolution reaction. Herein, we design a heterostructure catalyst to remedy the above issues, which consists of Ni nanosphere core and Ni(OH)2 nanosheet shell (Ni/Ni(OH)2)...
April 23, 2024: Angewandte Chemie
#31
JOURNAL ARTICLE
Bonnie Lam, Mark Velasquez, Tomoko Ogiyama, Kevin Godines, Fan-Yun Szu, A J Velasquez-Mao, Wissam AlGhuraibawi, Jingshen Wang, Phillip B Messersmith, Moriel H Vandsburger
PURPOSE: Gene therapy using adeno-associated virus (AAV) vector-mediated gene delivery has undergone substantial growth in recent years with promising results in both preclinical and clinical studies, as well as emerging regulatory approval. However, the inability to quantify the efficacy of gene therapy from cellular delivery of gene-editing technology to specific functional outcomes is an obstacle for efficient development of gene therapy treatments. Building on prior works that used the CEST reporter gene lysine rich protein, we hypothesized that AAV viral capsids may generate endogenous CEST contrast from an abundance of surface lysine residues...
April 23, 2024: Magnetic Resonance in Medicine
#32
JOURNAL ARTICLE
Tibor Auer, Robin Goldthorpe, Robert Peach, Henry Hebron, Ines R Violante
The unprecedented increase in life expectancy presents a unique opportunity and the necessity to explore both healthy and pathological aspects of ageing. Electroencephalography (EEG) has been widely used to identify neuromarkers of cognitive ageing due to its affordability and richness in information. However, despite the growing volume of data and methodological advancements, the abundance of contradictory and non-reproducible findings has hindered clinical translation. To address these challenges, our study introduces a comprehensive workflow expanding on previous EEG studies and investigates various static and dynamic power and connectivity estimates as potential neuromarkers of cognitive ageing in a large dataset...
April 15, 2024: Human Brain Mapping
#33
JOURNAL ARTICLE
Elin Larsson, Niklas Nilsson, Julia Walstern, Annelie Brorsson, Katarina Nilsson Helander
PURPOSE: There is a lack of knowledge concerning differences between females and males in the early stages after an acute Achilles tendon rupture. This article aims to explore the different factors affecting early function after an Achilles tendon rupture with a validated test battery that includes functional tests, clinical measurements and patient-reported outcome at a 3-month follow-up analysis of a larger prospective study. METHODS: This study was part of the DUSTAR-study (Diagnostic UltraSonography for the choice of Treatment of acute Achilles tendon Rupture) where the main aim was to evaluate if an acute ultrasonography could determine which patients, with an Achilles tendon rupture, should be treated surgically or nonsurgically...
April 23, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
#34
JOURNAL ARTICLE
Lisbeth Iglesias-Rios, Alexa Kort, Alexis J Handal
OBJECTIVES: Farmworkers in Michigan face precarious and exploitative labor conditions that affect their access to affordable, fair, and quality housing, which are key social determinants of health. We sought to assess the health, working conditions, and housing access, affordability, and quality of farmworkers living in and outside of employer-provided housing during the COVID-19 pandemic. METHODS: We conducted a mixed methods cross-sectional study in collaboration with community partners from the Michigan Farmworker Project and the Michigan Department of Civil Rights...
April 23, 2024: Journal of Agromedicine
#35
JOURNAL ARTICLE
Jean Lorenceau, Suzon Ajasse, Raphael Barbet, Muriel Boucart, Frédéric Chavane, Cédric Lamirel, Richard Legras, Frédéric Matonti, Maxence Rateaux, Jean-François Rouland, José-Alain Sahel, Laure Trinquet, Mark Wexler, Catherine Vignal-Clermont
We present a method for mapping multifocal Pupillary Response Fields in a short amount of time using a visual stimulus covering 40° of the visual angle divided into nine contiguous sectors simultaneously modulated in luminance at specific, incommensurate, temporal frequencies. We test this multifocal Pupillary Frequency Tagging (mPFT) approach with young healthy participants (N = 36) and show that the spectral power of the sustained pupillary response elicited by 45 s of fixation of this multipartite stimulus reflects the relative contribution of each sector/frequency to the overall pupillary response...
April 9, 2024: Vision
#36
JOURNAL ARTICLE
Isaac Ignacio-Rodríguez, Roberto Barcala-Furelos, Ezequiel Rey, Marcos Sanmartín-Montes
Coastal environments present dynamic challenges necessitating rapid and efficient responses during aquatic emergencies. Lifeguards, as pivotal links in the intervention chain, rely on various tools, with rescue time being paramount. The choice of fins, specifically long versus short ones, plays a critical role in optimizing lifeguard performance during rescues. This randomized cross-over study explores the impact of flipper size on ocean rescues, employing a sample of 14 lifeguards. Long fins (LFs) and short fins (SFs) were compared in terms of rescue time (RT) and physiological load (PL)...
April 19, 2024: Journal of Functional Morphology and Kinesiology
#37
JOURNAL ARTICLE
Marijan Peharec, Stanislav Peharec, Vedran Srhoj-Egekher, Romana Jerković, Dean Girotto, Gordana Starčević-Klasan
Although the measurements of the lumbar spine and pelvic flexion have shown that subjects with radiculopathy exhibited greater decreases of motion when compared with subjects with low back pain, there is still a lack of evidence regarding the changes in flexion relaxation ratio in patients with radiculopathy. The aims of this study were to investigate the flexion relaxation ratio and flexion of the lumbar spine and pelvis in subjects with low back pain (LBP) and LBP with radiculopathy (LBPR) in comparison with healthy subjects (CG-control group)...
April 19, 2024: Journal of Functional Morphology and Kinesiology
#38
JOURNAL ARTICLE
Ashley A Herda, Christopher J Cleary, Dana Young, KathleenMae B Rogers, Santiago E Umana Segura, Christopher Bernard, Lisa M Vopat, Bryan G Vopat
Blood flow restriction (BFR) is a commonly used training modality that has been demonstrated to enhance muscle characteristics such as size and function. The purpose of this study was to determine if a 4-week walking program with or without BFR in healthy, active adults has an effect on body composition, anaerobic, and aerobic running performance. Thirty-three participants, randomized among three groups, completed the walking program, which included five sets of 2 min walking intervals with 1 min rest, with or without BFR, or 10 min walking with BFR...
April 13, 2024: Journal of Functional Morphology and Kinesiology
#39
JOURNAL ARTICLE
Eleftherios Kellis, Athanasios Konstantopoulos, Georgios Salonikios, Athanasios Ellinoudis
The purpose of this study was to examine the effect of pelvic tilt angle on maximum hip and knee muscles' strength and antagonist/agonist strength ratios. Twenty-one young males and females performed maximum isokinetic concentric knee extension-flexion and hip extension-flexion efforts at 60°·s-1 , 120°·s-1 , and 180°·s-1 from three positions: anterior, neutral, and posterior pelvic tilt. Peak torques and knee flexor-to-extensor and hip flexor-to-extensor torque ratios were analyzed...
April 12, 2024: Journal of Functional Morphology and Kinesiology
#40
JOURNAL ARTICLE
Bruno V R Ramos, Danilo A Massini, Tiago A F Almeida, Eliane A Castro, Mário C Espada, Cátia C Ferreira, Ricardo A M Robalo, Anderson G Macedo, Dalton M Pessôa Filho
Among the stimuli able to prevent early decreases in bone mineralization, exercise has a noticeable role per se as the source of mechanical stimulus or through lean tissue enlargement by its increasing of tensional stimulus. However, prevention strategies, including exercise, generally do not establish the moment in life when attention should begin to be paid to bone integrity, according to age group- and sex-related differences. Thus, this study analyzed the relationship between variables from the diagnosis of total and regional body composition, muscle strength, and bone mineral content (BMC) of femurs in young adult males...
April 9, 2024: Journal of Functional Morphology and Kinesiology
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