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https://www.readbyqxmd.com/read/29356451/gene-encoding-the-ctp-synthetase-as-an-appropriate-molecular-tool-for-identification-and-phylogenetic-study-of-the-family-bifidobacteriaceae
#1
Jiří Killer, Chahrazed Mekadim, Radko Pechar, Věra Bunešová, Jakub Mrázek, Eva Vlková
An alternative molecular marker with respect to the 16S rRNA gene demonstrating better identification and phylogenetic parameters has not been designed for the whole Bifidobacteriaceae family, which includes the genus Bifidobacterium and scardovial genera. Therefore, the aim of the study was to find such a gene in available genomic sequences, suggest appropriate means and conditions for asmplification and sequencing of the desired region of the selected gene in various strains of the bacterial family and verify the importance in classification and phylogeny...
January 22, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29356446/local-and-systemic-immune-responses-to-different-types-of-phytohemagglutinin-in-the-green-anole-lessons-for-field-ecoimmunologists
#2
Catherine Tylan, Tracy Langkilde
The phytohemagglutinin (PHA) skin test is commonly used by ecologists to assess cell-mediated immune function of wild animals. It can be performed quickly and easily in the field, involving injection of PHA and measurement of the resultant swelling. There are multiple formulations of PHA used in ecological studies, with potentially differing outcomes that could produce inconsistent results. We tested two common types of PHA in the green anole (Anolis carolinensis) to identify local and systemic immune responses underlying the resultant swelling at 6, 18, 24, and 48 hr post injection...
June 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356436/health-insurance-and-use-of-recommended-routine-care-in-adults-with-cystic-fibrosis
#3
Susan S Li, Don Hayes, Joseph D Tobias, Wayne J Morgan, Dmitry Tumin
BACKGROUND: Low socioeconomic status is correlated with worse outcomes in patients with cystic fibrosis. Whether insurance status impacts adherence to care in this population is unknown. METHODS: Patients ≥18 years old in the CF Foundation Patient Registry (2005-2013) were grouped based on reported annual insurance as private, public (Medicaid, Medicare, or state medical assistance program), other, or no insurance. Random effects logistic regression evaluated association between change in insurance status and annual use of recommended routine care...
January 22, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29356433/cardiopulmonary-exercise-test-to-quantify-enzyme-replacement-response-in-pediatric-pompe-disease
#4
Ronen Bar-Yoseph, Hanna Mandel, Gur Mainzer, Michal Gur, Galit Tal, George Shalloufeh, Lea Bentur
INTRODUCTION: Enzyme replacement therapy (ERT) with Myozyme improved the prospect of Pompe disease patients. Our aim was to evaluate ERT acute effect on exercise capacity in pediatric Pompe patients. METHODS: Five Pompe patients (10-19 years, 4 infantile-onset and 1 diagnosed at 5 years) were evaluated before and 2 days after ERT using cardiopulmonary exercise testing (CPET), 6 min walking test (6MWT) and motor function test (GMFM-88). RESULTS: Preserved normal peak oxygen uptake, 6MWT and motor function were observed in the relative mild disease and impairment of these parameters in the more advanced disease...
January 22, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29356424/immune-variation-during-pregnancy-suggests-immune-component-specific-costs-of-reproduction-in-a-viviparous-snake-with-disparate-life-history-strategies
#5
Maria G Palacios, Anne M Bronikowski
Growing evidence suggests the existence of trade-offs between immune function and reproduction in diverse taxa. Among vertebrates, however, there is still a taxonomic bias toward studies in endotherms, particularly birds. We tested the hypothesis that reproduction entails immune-related costs in the viviparous garter snake, Thamnophis elegans, from populations that exhibit two life-history strategies, termed ecotypes, with contrasting paces of life. Between the two ecotypes, we predicted lower immune function in gravid than non-gravid females of both strategies, but with relatively larger immunity costs in the ecotype that generally invests more in current reproduction...
October 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356420/copy-number-variation-of-a-protease-gene-of-daphnia-its-role-in-population-tolerance
#6
Anke Schwarzenberger, Nathan R Keith, Craig E Jackson, Eric Von Elert
Copy number variation (CNV) of genes coding for certain enzymes has been shown to be responsible for adaptation of arthropods to anthropogenic toxins. Natural toxins produced by cyanobacteria in freshwater ecosystems, that is, protease inhibitors (PIs), have been demonstrated to increase in frequency over the last decades due to eutrophication and global warming. These PIs inhibit digestive proteases of Daphnia, the major herbivore of phytoplankton and cyanobacteria. The adjustment of isoforms, differences in gene expression, and activity of gut proteases determine tolerance to dietary PIs in single Daphnia genotypes...
February 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356348/skeletal-muscle-ex%C3%A2-vivo-mitochondrial-respiration-parallels-decline-in%C3%A2-vivo-oxidative-capacity-cardiorespiratory-fitness-and-muscle-strength-the-baltimore-longitudinal-study-of-aging
#7
Marta Gonzalez-Freire, Paul Scalzo, Jarod D'Agostino, Zenobia A Moore, Alberto Diaz-Ruiz, Elisa Fabbri, Ariel Zane, Brian Chen, Kevin G Becker, Elin Lehrmann, Linda Zukley, Chee W Chia, Toshiko Tanaka, Paul M Coen, Michel Bernier, Rafael de Cabo, Luigi Ferrucci
Mitochondrial function in human skeletal muscle declines with age. Most evidence for this decline comes from studies that assessed mitochondrial function indirectly, and the impact of such deterioration with respect to physical function has not been clearly delineated. We hypothesized that mitochondrial respiration in permeabilized human muscle fibers declines with age and correlates with phosphocreatine postexercise recovery rate (kPCr), muscle performance, and aerobic fitness. Mitochondrial respiration was assessed by high-resolution respirometry in saponin-permeabilized fibers from vastus lateralis muscle biopsies of 38 participants from the Baltimore Longitudinal Study of Aging (BLSA; 21 men, age 24-91 years) who also had available measures of peak oxygen consumption (VO2max ) from treadmill tests, gait speed in different tasks, 31 P magnetic resonance spectroscopy, isokinetic knee extension, and grip strength...
January 21, 2018: Aging Cell
https://www.readbyqxmd.com/read/29356345/four-days-of-simulated-shift-work-reduces-insulin-sensitivity-in-humans
#8
R Bescos, M J Boden, M L Jackson, A J Trewin, E C Marin, I Levinger, A Garnham, D S Hiam, F Falcao-Tebas, F Conte, J A Owens, D J Kennaway, G K McConell
AIM: The aim of this study was to investigate the effects of four consecutive simulated night shifts on glucose homeostasis, mitochondrial function and central and peripheral rhythmicity compared with a simulated day shift schedule. METHODS: Seventeen healthy adults (8M:9F) matched for sleep, physical activity, and dietary/fat intake participated in this study (night shift work n= 9; day shift work n= 8). Glucose tolerance and insulin sensitivity before and after 4 nights of shift work were measured by an intravenous glucose tolerance test and a hyperinsulinemic euglycemic clamp, respectively...
January 22, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29356322/synthesis-and-characterization-of-biogenic-selenium-nanoparticles-with-antimicrobial-properties-made-by-staphylococcus-aureus-methicillin-resistant-staphylococcus-aureus-mrsa-escherichia-coli-and-pseudomonas-aeruginosa
#9
David Medina Cruz, Gujie Mi, Thomas J Webster
Antimicrobial resistance is a global concern that affects more than 2 million people each year. Therefore, new approaches to kill bacteria are needed. One of the most promising methodologies may come from metallic nanoparticles, since bacteria may not develop a resistance to these nanostructures as they do for antibiotics. While metallic nanoparticle synthesis methods have been well studied, they are often accompanied by significant drawbacks such as cost, extreme processing conditions and toxic waste production since they use harsh chemicals such as corrosive agents (hydrazine) or strong acids (hydrochloride acid)...
January 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29356277/assessment-of-the-efficacy-of-a-new-complex-antisensitive-skin-cream
#10
Yinjuan Wang, Céline Viennet, Adeline Jeudy, Ferial Fanian, Li He, Philippe Humbert
BACKGROUND: Sensitive skin is frequently complaint in dermatology consultation with cutaneous manifestations such as stinging, redness, dryness, and burning sensation that affect the quality of life. Its pathogenesis is mainly related to dysfunction of neurosensory, skin barrier, and also immune activity. The treatment is generally based on continuous and topical therapy by nonirritating complex. OBJECTIVE: To evaluate the antisensitive function of a new complex cream composed by Yunnan Portulaca oleracea extract, Prinsepia utilis oil, beta-glucan, and sodium hyaluronate extracted from mushroom...
January 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29356252/white-matter-integrity-disruptions-correlate-with-cognitive-impairments-in-asthma
#11
Rongrong Bian, Yuqun Zhang, Yuan Yang, Yingying Yin, Xiaoxin Zhao, Huanxin Chen, Yonggui Yuan
BACKGROUND: Cognitive impairments are common in asthma, which is a serious global health problem characterized by chronic airway inflammation. However, the underlying neuromechanism is still unclear. PURPOSE/HYPOTHESIS: To investigate the neuromechanism underlying cognitive impairments of asthma. We hypothesized that asthma patients exhibit altered white matter (WM) microstructures, which may contribute to their cognitive impairments. STUDY TYPE: Case-control study...
January 21, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29356210/clinical-course-and-prognostic-factors-across-different-musculoskeletal-pain-sites-a-secondary-analysis-of-individual-patient-data-from-randomised-clinical-trials
#12
D J Green, M Lewis, G Mansell, M Artus, K S Dziedzic, E M Hay, N E Foster, D A van der Windt
BACKGROUND: Previous research has identified similar prognostic factors in patients with musculoskeletal (MSK) conditions regardless of pain presentation, generating opportunities for management based on prognosis rather than specific pain presentation. METHODS: Data from seven RCTs (2,483 participants) evaluating a range of primary care interventions for different MSK pain conditions were used to investigate the course of symptoms and explore similarities and differences in predictors of outcome...
January 22, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29356148/electron-injection-promoted-high-oxygen-evolution-activity-of-co-ni-alloy-nanochains
#13
Xiaotao Yuan, Muhammad Sohail Riaz, Xin Wang, Chenlong Dong, Zhe Zhang, Fu-Qiang Huang
Metal alloy nanoparticles have shown promising applications in electrocatalysis. However, the nanoparticles usually suffer from limited charge transfer efficiency, which can be solved by preparing one-dimensional materials. In this work, Co-Ni alloy nanochains are prepared by a direct-current arc-discharge method. The nanochains, comprised of uniform nanospheres coupled to each other, can range up to several micrometers. When the alloy is exposed to the air or under the electro oxidation process, a metal-metal oxide heterostructure is obtained...
January 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29356147/kisspeptin-neurones-in-the-posterodorsal-medial-amygdala-modulate-sexual-partner-preference-and-anxiety-in-male-mice
#14
D A Adekunbi, X F Li, G Lass, K Shetty, O A Adegoke, S H Yeo, W H Colledge, S L Lightman, K T O'Byrne
The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is however limited information on the specific neuronal cell type in the MePD functionally mediating these behaviours in rodents. The recent discovery of a significant kisspeptin neurone population in the MePD has raised interest in the possible role of kisspeptin and its cognate receptor in sexual behaviour. This study therefore tested the hypothesis that the MePD kisspeptin neurone population is involved in regulating attraction towards opposite sex conspecifics, sexual behaviour, social interaction and anxiety response by selectively stimulating these neurones using the novel pharmacosynthetic DREADDs (designer receptors exclusively activated by designer drugs) technique...
January 22, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29356100/layer-specific-deformation-analysis-in-severe-aortic-valve-stenosis-primary-mitral-valve-regurgitation-and-healthy-individuals-validated-against-invasive-hemodynamic-measurements-of-heart-function
#15
Rine Bakkestrøm, Nicolaj L Christensen, Emil Wolsk, Ann Banke, Jordi S Dahl, Mads J Andersen, Finn Gustafsson, Christian Hassager, Jacob E Møller
AIM: Speckle tracking echocardiography is considered valuable in assessing left ventricular (LV) function. The method has been refined to assess deformation in different myocardial layers, but the effect of volume vs pressure overload on this pattern is unknown. The aim was to test whether layer-specific myocardial strain (LSS) obtained by speckle tracking echocardiography exhibits different patterns in conditions with different loading conditions. METHODS AND RESULTS: Forty patients with asymptomatic severe aortic stenosis (AS) (AVA 0...
January 21, 2018: Echocardiography
https://www.readbyqxmd.com/read/29356088/exposure-of-the-developing-heart-to-diabetic-environment-and-early-cardiac-assessment-a-review
#16
REVIEW
Mehmet R Asoglu, Rinat Gabbay-Benziv, Ozhan M Turan, Sifa Turan
Hyperglycemia during organogenesis is associated with an increased risk of congenital cardiac defects (CHDs). The pathophysiology leading to CHDs is not completely uncovered. However, elevated oxidative stress is considered to be the primary trigger that causes CHDs in fetuses of diabetic mothers. Maternal diabetes has been found to increase the risk for all types of CHDs. Diabetes may also impact the fetal cardiac performance at all gestational ages. Early detection of CHDs has certain advantages, such as making early decision about termination of pregnancy, enabling early genetic testing, and early reassurance if scan is normal...
January 21, 2018: Echocardiography
https://www.readbyqxmd.com/read/29355953/investigation-into-the-microstructure-texture-and-rheological-properties-of-chocolate-ganache
#17
Jade McGill, Rich W Hartel
Ganache is a mixture of chocolate and dairy. Although a popular confection, little is known about how it functions as a system. Objectives were to (1) determine if dairy fats and cocoa butter mix in ganache, (2) characterize ganache microstructure, and how structure affects texture and rheology, and (3) identify how changes in chocolate composition alter ganache. Textural analysis, differential scanning calorimetry, stress sweep tests, and microscopy were used to examine ganache formulations that varied in dairy source (cream or butter) or in solid fat content (SFC), composition or type of chocolate...
January 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29355911/the-brain-health-assessment-for-detecting-and-diagnosing-neurocognitive-disorders
#18
Katherine L Possin, Tacie Moskowitz, Sabrina J Erlhoff, Kirsten M Rogers, Erica T Johnson, Natasha Z R Steele, Joseph J Higgins, Jordan Stiver, Andrea G Alioto, Sarah T Farias, Bruce L Miller, Katherine P Rankin
BACKGROUND/OBJECTIVES: Brief cognitive screens lack the sensitivity to detect mild cognitive impairment (MCI) or support differential diagnoses. The objective of this study was to validate the 10-minute, tablet-based University of California, San Francisco (UCSF) Brain Health Assessment (BHA) to overcome these limitations. DESIGN: Cross-sectional. SETTING: UCSF Memory and Aging Center. PARTICIPANTS: Older adults (N = 347) (neurologically healthy controls (n = 185), and individuals diagnosed with MCI (n = 99), dementia (n = 42), and as normal with concerns (n = 21))...
January 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29355860/interface-engineered-in-situ-anchoring-of-co9s8-nanoparticles-into-a-multiple-doped-carbon-matrix-highly-efficient-zinc-air-batteries
#19
Yang Li, Wei Zhou, Juncai Dong, Yun Luo, Pengfei An, Juan Liu, Xin Wu, Guilan Xu, Huabin Zhang, Jian Zhang
Interface modification is an effective and promising route for developing functional electrocatalysts. However, researchers have not created a reliable method to optimize the interfaces of components existing in electrocatalysts, although it is very crucial for the technological development of high-performance electrodes. Here, we develop a strategy aiming at the in situ anchorage of Co9S8 nanoparticles into a nitrogen (N), sulfur (S) co-implanted three-dimensional carbon matrix (Co9S8@NSCM) as a highly active and durable nonprecious metal electrocatalyst for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in alkaline medium...
January 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29355820/association-of-cytomegalovirus-and-epstein-barr-virus-with-cognitive-functioning-and-risk-of-dementia-in-the-general-population-11-year-follow-up-study
#20
Minna Torniainen-Holm, Jaana Suvisaari, Maija Lindgren, Tommi Härkänen, Faith Dickerson, Robert H Yolken
BACKGROUND: Earlier studies have documented an association between cytomegalovirus and cognitive impairment, but results have been inconsistent. Few studies have investigated the association of cytomegalovirus and Epstein-Barr virus with cognitive decline longitudinally. Our aim was to examine whether cytomegalovirus and Epstein-Barr virus are associated with cognitive decline in adults METHOD: The study sample is from the Finnish Health 2000 Survey (BRIF8901, n = 7112), which is representative of the Finnish adult population...
January 16, 2018: Brain, Behavior, and Immunity
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