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https://www.readbyqxmd.com/read/29779212/periodontal-regeneration-via-chemo-attractive-constructs
#1
Xinjie Cai, Fang Yang, X Frank Walboomers, Yining Wang, John A Jansen, Jeroen J J P van den Beucken, Adelina S Plachokova
AIM: Chemo-attractants, such as stromal cell-derived factor-1α (SDF-1α), can offer an advantage for periodontal regeneration by recruiting the patient's own stem cells to stimulate self-repair. We here developed a chemo-attractive construct for periodontal regeneration using SDF-1α and evaluated its efficacy in vivo. MATERIALS AND METHODS: SDF-1α was loaded on gelatin sponge and tested in vitro for SDF-1α release. Subsequently, SDF-1α constructs were implanted into rat periodontal defects for 1 and 6 weeks, with unloaded materials and empty defects as controls...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29779177/computational-identification-of-structural-factors-affecting-the-mutagenic-potential-of-aromatic-amines-study-design-and-experimental-validation
#2
Svetoslav H Slavov, Iva Stoyanova-Slavova, William Mattes, Richard D Beger, Beat J Brüschweiler
A grid-based, alignment-independent 3D-SDAR (three-dimensional spectral data-activity relationship) approach based on simulated 13 C and 15 N NMR chemical shifts augmented with through-space interatomic distances was used to model the mutagenicity of 554 primary and 419 secondary aromatic amines. A robust modeling strategy supported by extensive validation including randomized training/hold-out test set pairs, validation sets, "blind" external test sets as well as experimental validation was applied to avoid over-parameterization and build Organization for Economic Cooperation and Development (OECD 2004) compliant models...
May 19, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29779143/health-related-quality-of-life-in-coronary-heart-disease-a-systematic-review-and-meta-analysis-mapped-against-the-international-classification-of-functioning-disability-and-health
#3
REVIEW
Jana Le, Diana S Dorstyn, Elias Mpfou, Elise Prior, Phillip J Tully
BACKGROUND: Health-related quality of life (HRQoL) is an important outcome in coronary heart disease (CHD). However, variability in HRQoL indicators suggests a need to consider domain coverage. This review applies a globally accepted framework, the International Classification of Functioning, Disability and Health (ICF), to map HRQoL measures that are reliable and valid among people with CHD. METHODS: The Embase, Pubmed and PsycInfo databases were searched, with 10 observational studies comparing HRQOL among 4786 adults with CHD to 50949 controls identified...
May 19, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29779020/acetaminophen-reduces-acute-and-persistent-incisional-pain-after-hysterectomy
#4
Onur Koyuncu, Sedat Hakimoglu, Mustafa Ugur, Cagla Akkurt, Selim Turhanoglu, Daniel Sessler, Alparslan Turan
OBJECTIVE: Acetaminophen is effective for acute surgical pain, but whether it reduces persistent incision pain remains unknown. We tested the primary hypothesis that patients given perioperative acetaminophen have less incisional pain three months after surgery. Our secondary hypotheses were that patients randomized to acetaminophen have less postoperative pain and analgesic consumption, and better functional recovery at three months. METHODS: 140 patients having abdominal hysterectomy were randomly assigned to: 1)intravenous acetaminophen (4 g/day for 72 postoperative hours); or, 2) saline placebo...
May 15, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29779002/developing-a-testing-battery-for-measuring-dogs-stifle-functionality-the-finnish-canine-stifle-index-fcsi
#5
Heli K Hyytiäinen, Sari H Mölsä, Jouni J T Junnila, Outi M Laitinen-Vapaavuori, Anna K Hielm-Björkman
This study aimed at developing a quantitative testing battery for dogs' stifle functionality, as, unlike in human medicine, currently none is available in the veterinary field. Forty-three dogs with surgically treated unilateral cranial cruciate ligament rupture and 21 dogs with no known musculoskeletal problems were included. Eight previously studied tests: compensation in sitting and lying positions, symmetry of thrust in hindlimbs when rising from lying and sitting, static weight bearing, stifle flexion and extension and muscle mass symmetry, were summed into the Finnish Canine Stifle Index (FCSI)...
May 19, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29778987/effect-of-ethanol-dissolved-rhodamine-b-marker-on-mechanical-properties-of-non-simplified-adhesives
#6
Camila Moreira Machado, Odair Bim Júnior, Marina Ciccone Giacomini, Márcia Sirlene Zardin Graeff, Fernanda Cristina Pimentel Garcia, Daniela Rios, Heitor Marques Honório, Linda Wang
OBJECTIVES: Rhodamine B (RB) is commonly used to evaluate dental polymers, including dental bonding systems (DBS). For reliability assessments, its effect should not only allow visualization of the dentin-polymer interface but also must not interfere with the bonding of the DBS to dentin as measured by the microtensile bond strength and hardness tests. MATERIAL AND METHODS: Flat human dentin surfaces were prepared and randomly distributed (n = 10) into six groups: Adper Scotchbond Multi-Purpose (MP) or Clearfil SE Bond (SE) in concentrations of none/control, 0...
May 17, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29778936/timed-instrumental-activities-of-daily-living-in-multiple-sclerosis-the-test-of-everyday-cognitive-ability-teca
#7
Leigh E Charvet, Michael T Shaw, Kathleen Sherman, Shannon Haas, Lauren B Krupp
OBJECTIVE: Cognitive impairment is a common symptom of multiple sclerosis (MS) that can lead to declines in daily functioning. Timed instrumental activities of daily living (TIADLs) have been useful to bridge between cognitive testing and real-world functioning in disorders such as Alzheimer's disease and other dementias. However, these have not been standardized for general use, and the tasks that are typically employed have not been sensitive to the detection of milder forms of cognitive deficits...
May 3, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29778921/goat-boule-isoforms-identification-mrna-expression-in-testis-and-functional-study-and-promoter-methylation-profiles
#8
Xiaoyan Zhang, Shuai Yu, Qing Yang, Ke Wang, Sihuan Zhang, Chuanying Pan, Hailong Yan, Ruihua Dang, Chuzhao Lei, Hong Chen, Xianyong Lan
A conserved gene in meiosis, the Boule gene is involved in meiosis and spermatogenesis. The deletion of this gene in males blocks meiosis and results in infertility. Alternative splicing variants of the Boule gene have been identified in humans, bovines, and bats, but in dairy goats remains unknown. This study was therefore to detect splicing variants of the goat Boule gene and explore their potential roles in meiosis. Three isoforms, denoted as Boule-a, Boule-b, and Boule-c, were identified in the testes of goats using real-time PCR (RT-PCR) and cloning sequencing...
May 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29778872/derivatization-method-for-the-quantification-of-lactic-acid-in-cell-culture-media-via-gas-chromatography-and-applications-in-the-study-of-cell-glycometabolism
#9
Hua-Yin Zhang, Ping-Ping Zhang, Xiao-Xin Tan, Ze-Ze Wang, Kao-Qi Lian, Xiang-Dong Xu, Wei-Jun Kang
Lactic acid represents an important metabolite that reflects mitochondria function and may further serve as energy source for cancer cells. In light of this physiological and pathological significance, we developed a novel and sensitive gas chromatography method to detect lactic acid in cell culture media. Here, ethyl chloroformate was selected as derivative reagent and the derivatization process was further optimized in terms of number of reagents and reaction time as well as extraction reagents. Under optimal conditions, good linearity was achieved in the tested calibration range...
May 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29778857/development-of-a-risk-score-based-on-aortic-calcification-to-predict-1-year-mortality-after-transcatheter-aortic-valve-replacement
#10
Pierre Lantelme, Hélène Eltchaninoff, Muriel Rabilloud, Géraud Souteyrand, Marion Dupré, Marco Spaziano, Marc Bonnet, Clément Becle, Benjamin Riche, Eric Durand, Erik Bouvier, Jean-Nicolas Dacher, Pierre-Yves Courand, Lucie Cassagnes, Eduardo E Dávila Serrano, Pascal Motreff, Loic Boussel, Thierry Lefèvre, Brahim Harbaoui
OBJECTIVES: The aim of this study was to develop a new scoring system based on thoracic aortic calcification (TAC) to predict 1-year cardiovascular and all-cause mortality. BACKGROUND: A calcified aorta is often associated with poor prognosis after transcatheter aortic valve replacement (TAVR). A risk score encompassing aortic calcification may be valuable in identifying poor TAVR responders. METHODS: The C4 CAPRI (4 Cities for Assessing CAlcification PRognostic Impact) multicenter study included a training cohort (1,425 patients treated using TAVR between 2010 and 2014) and a contemporary test cohort (311 patients treated in 2015)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778826/intra-and-inter-rater-reliabilities-for-novel-muscle-thickness-assessment-during-co-contraction-with-dual-rehabilitative-ultrasound-imaging
#11
Hwang-Jae Lee, Hyun-Geun Ha, Joohee Hahn, Seungyeop Lim, Wan-Hee Lee
OBJECTIVES: This study aimed to investigate the intra- and inter-rater reliabilities of dual-rehabilitative ultrasound imaging (D-RUSI) for the simultaneous measurement of the thickness of the tibialis anterior (TA) and gastrocnemius (GCM) muscles in healthy young adults. DESIGN: A single-group repeated-measures reliability study. SETTING: Rehabilitative ultrasound imaging analysis laboratory. PARTICIPANTS: Thirty-six healthy participants (23 males; age = 26...
May 17, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29778806/evaluation-of-antioxidant-potential-of-novel-layered-double-hydroxides-with-caal-and-nial-loaded-with-olanzapine
#12
João Gomes Pontes-Neto, Danilo Augusto Ferreira Fontes, Magaly Andreza Marques de Lyra, Maria Dos Remédios Mendes de Brito, Luíse Lopes Chaves, Pedro José Rolim-Neto, Mônica Felts De La Roca Soares, Lucindo Jose Quintans Júnior, Rivelilson Mendes de Freitas, José Lamartine Soares-Sobrinho
Olanzapine (OLZ), Class II in the Biopharmaceutical Classification System, has low aqueous solubility, hindering its absorption after administration. It is used in the bipolar disorder and schizophrenia treatment, diseases that present the oxidative stress in their pathophysiology. In the search for new Drug Delivery Systems (DDS) that enhance the OLZ dissolution rate, it is also necessary to investigate its antioxidant potential for better understanding. Thus, this study aimed to evaluate the in vitro antioxidant potential of new olanzapine DDS based on two different types of Layered Double Hydroxides (LDH systems)...
May 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29778778/swimming-improves-cognitive-reserve-in-ovariectomized-rats-and-enhances-neuroprotection-after-global-cerebral-ischemia
#13
Meng Zhang, Yating Zhai, Yaping Sun, Wenli Zhang, Qian Li, Darrell Brann, Ruimin Wang
Cognitive reserve has been proposed to account for different responses to brain damage or pathology. Factors implicated to influence cognitive reserve include cognitive engagement, physical activity, leisure activities, stress levels, and diet. Furthermore, long-term ovariectomy (OVX), such as occurs in women that have underwent surgical menopause, has been reported to increase the risk of cognitive impairment. In the current study, we examined whether swimming improves cognitive function in long-term OVX-rats...
May 17, 2018: Brain Research
https://www.readbyqxmd.com/read/29778671/international-study-of-comparative-health-effectiveness-with-medical-and-invasive-approaches-ischemia-trial-rationale-and-design
#14
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29778669/thyroid-status-in-premenopausal-and-postmenopausal-women-a-biochemical-study-on-insulin-resistance-in-non-obese-overweight-and-obese-type-2-diabetics
#15
Rajendran Jayanthi, Abu Raghavan Srinivasan, Gopal Niranjan
BACKGROUND: Insulin resistance with altered thyroid status in women is observed in type 2 diabetics and varies with advancing age and estrogen profile. We compared thyroid status between premenopausal and postmenopausal women in obese, non obese and overweight type 2 diabetes. METHODOLOGY: We included 301type 2 diabetics who were segregated into premenopausal (n = 100) 33.2% and postmenopausal (n = 201) 66.8% among three sub groups (Non obese, overweight and Obese)...
May 10, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29778656/laxity-and-contact-forces-of-total-knee-designed-for-anatomic-motion-a-cadaveric-study
#16
Gaia Salvadore, Patrick A Meere, Matthias A Verstraete, Jan Victor, Peter S Walker
BACKGROUND: Total knee designs that attempt to reproduce more physiological knee kinematics are gaining attention given their possible improvement in functional outcomes. This study examined if a total knee designed for anatomic motion, where the soft tissue balancing was intended to replicate anatomical tibiofemoral contact forces, can more closely reproduce the laxity of the native knee. METHODS: In an ex-vivo setting, the laxity envelope of the knees from nine lower extremity specimens was measured using a rig that reproduced surgical conditions...
May 16, 2018: Knee
https://www.readbyqxmd.com/read/29778641/subregional-volumes-of-the-hippocampus-in-relation-to-cognitive-function-and-risk-of-dementia
#17
Tavia E Evans, Hieab H H Adams, Silvan Licher, Frank J Wolters, Aad van der Lugt, M Kamran Ikram, Michael J O'Sullivan, Meike W Vernooij, M Arfan Ikram
BACKGROUND: Total hippocampal volume has been consistently linked to cognitive function and dementia. Yet, given its complex and parcellated internal structure, the role of subregions of the hippocampus in cognition and risk of dementia remains relatively underexplored. We studied subregions of the hippocampus in a large population-based cohort to further understand their role in cognitive impairment and dementia risk. METHODS: We studied 5035 dementia- and stroke-free persons from the Rotterdam Study, aged over 45 years...
May 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29778539/expressional-and-functional-comparisons-of-two-general-odorant-binding-proteins-in-agrotis-ipsilon
#18
Guang-Zhen Huang, Jing-Tao Liu, Jing-Jiang Zhou, Qian Wang, Jian-Zhen Dong, Yong-Jun Zhang, Xian-Chun Li, Jing Li, Shao-Hua Gu
Insect general odorant binding proteins (GOBPs) have been long thought to bind and transport host plant volatiles to the olfactory receptors on the dendrite membrane of the olfactory neurons. Recent studies indicate that they can also bind female sex pheromones. In present study, two GOBP genes, AipsGOBP1 and AipsGOBP2 were cloned from the adult antennae of Agrotis ipsilon. Tissue expression profiles indicated that both of them are antennae-specific and more abundant in the female antennae than in the male antennae...
May 17, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29778510/assessment-of-intestinal-failure-associated-liver-disease-according-to-different-diagnostic-criteria
#19
Anna Simona Sasdelli, Federica Agostini, Caterina Pazzeschi, Mariacristina Guidetti, Simon Lal, Loris Pironi
BACKGROUND & AIMS: Intestinal failure associated liver disease (IFALD) has been defined using numerous criteria; however the clinical relevance of these criteria has never been compared. We therefore aimed to evaluate the prevalence, incidence, evolution of IFALD diagnosed by different criteria and to assess any clinical features that may be associated with its occurrence. METHODS: A cross sectional (CS) and retrospective study were carried out on adults on home parenteral nutrition (HPN) for chronic intestinal failure (CIF) managed at a single center...
May 8, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29778471/influence-of-protein-content-and-storage-temperature-on-the-particle-morphology-and-flowability-characteristics-of-milk-protein-concentrate-powders
#20
Karthik Sajith Babu, Kaliramesh Siliveru, J K Amamcharla, Praveen V Vadlani, R P Kingsly Ambrose
Milk protein concentrate (MPC) powders are widely used as ingredients for food product formulations due to their nutritional profile and sensory attributes. Processing parameters, storage conditions, and composition influences the flow properties of MPC powders. This study investigated the bulk and shear flow properties of 70.3, 81.5, and 88.1% (wt/wt, protein content) MPC after storage for 12 wk at 25 and 40°C. Additionally, the morphological and functional changes of the MPC powders were investigated and correlated with flowability...
May 16, 2018: Journal of Dairy Science
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