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hepatitis B guidelines

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https://www.readbyqxmd.com/read/29312973/critical-appraisal-of-chinese-2017-guideline-on-the-management-of-hepatocellular-carcinoma
#1
REVIEW
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
Hepatocellular carcinoma (HCC) is the fourth most common and the third most lethal cancer in China. An updated version of consensus-based recommendations on the management of HCC has been recently published by a multidisciplinary group of Chinese experts including liver surgeons, hepatic oncologists, radiologists and pathologists. Major changes have been made to the diagnostic criteria. In addition to dynamic multi-detector computed tomography (CT) and magnetic resonance imaging (MRI), gadoxetic acid-enhanced MRI and contrast-enhanced ultrasound (CEUS) are added to the diagnostic imaging tests...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29311398/acute-variceal-bleeding-does-octreotide-improve-outcomes-in-patients-with-different-functional-hepatic-reserve
#2
Roberto Monreal-Robles, Carlos A Cortez-Hernández, José A González-González, Juan G Abraldes, Francisco J Bosques-Padilla, Héctor N Silva-Ramos, Jorge A García-Flores, Héctor J Maldonado-Garza
BACKGROUND: Current guidelines do not differentiate in the utilization of vasoactive drugs in patients with cirrhosis and acute variceal bleeding (AVB) depending on liver disease severity. MATERIAL AND METHODS: In this retrospective study, clinical outcomes in 100 patients receiving octreotide plus endoscopic therapy (ET) and 216 patients with ET alone were compared in terms of failure to control bleeding, in-hospital mortality, and transfusion requirements stratifying the results according to liver disease severity by Child-Pugh (CP) score and MELD...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29310928/sofosbuvir-and-velpatasvir-for-hepatitis-c-virus-infection-in-people-with-recent-injection-drug-use-simplify-an-open-label-single-arm-phase-4-multicentre-trial
#3
Jason Grebely, Olav Dalgard, Brian Conway, Evan B Cunningham, Philip Bruggmann, Behzad Hajarizadeh, Janaki Amin, Julie Bruneau, Margaret Hellard, Alain H Litwin, Philippa Marks, Sophie Quiene, Sharmila Siriragavan, Tanya L Applegate, Tracy Swan, Jude Byrne, Melanie Lacalamita, Adrian Dunlop, Gail V Matthews, Jeff Powis, David Shaw, Maria Christine Thurnheer, Martin Weltman, Ian Kronborg, Curtis Cooper, Jordan J Feld, Chris Fraser, John F Dillon, Phillip Read, Ed Gane, Gregory J Dore
BACKGROUND: Despite revised guidelines that no longer exclude people who inject drugs (PWID) from treatment for hepatitis C virus (HCV) infection, many clinicians are reluctant to treat recent PWID. This study aimed to evaluate the efficacy of sofosbuvir and velpatasvir therapy in people with chronic HCV infection and recent injection drug use. METHODS: In this open-label, single-arm phase 4 trial (SIMPLIFY), we recruited participants with recent injection drug use (past 6 months) and chronic HCV genotype 1-6 infection from seven countries (19 sites)...
January 5, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29305946/a-whole-grain-diet-reduces-peripheral-insulin-resistance-and-improves-glucose-kinetics-in-obese-adults-a-randomized-controlled-trial
#4
Steven K Malin, Emily L Kullman, Amanda R Scelsi, Jacob M Haus, Julianne Filion, Mangesh R Pagadala, Jean-Philippe Godin, Sunil Kochhar, Alastair B Ross, John P Kirwan
BACKGROUND: Whole-grain intake is associated with lower risk of type 2 diabetes but mechanisms are unclear. PURPOSE: We tested the hypothesis that a WG diet reduces insulin resistance and improves glucose use in individuals at risk for type 2 diabetes compared with an isocaloric-matched refined-grain diet. METHODS: A double-blind, randomized, controlled, crossover trial of 14 moderately obese adults (Age, 38±2 yrs.; BMI, 34.0±1.1kg/m2). Insulin resistance and glucose metabolism was assessed using an oral glucose tolerance test combined with isotopic tracers of [6,6-2H2]-glucose and [U-13C]-glucose, and indirect calorimetry...
January 3, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29303103/diagnosis-management-and-treatment-of-hepatitis-b-virus-infection-turkey-2017-clinical-practice-guidelines
#5
Fehmi Tabak, Cihan Yurdaydın, Sabahattin Kaymakoğlu, Mesut Akarsu, Esra G Akıncı, Hikmet Akkız, Canan Alkım, Ayhan H Çekin, Nefise Ö Çuvalcı, Kadir Demir, Bülent Değertekin, İlyas Dökmetaş, Galip Ersöz, Kenan Hizel, Fatma Ö Kandemir, Yusuf Önlen, Abdullah Sonsuz, Ebubekir Şenateş, Selma Tosun, Nurdan Tözün, Ramazan Idilman, Viral Hepatitis Guidelines Study Group
No abstract text is available yet for this article.
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29301497/evaluating-screening-approaches-for-hepatocellular-carcinoma-in-a-cohort-of-hcv-related-cirrhosis-patients-from-the-veteran-s-affairs-health-care-system
#6
Nabihah Tayob, Peter Richardson, Donna L White, Xiaoying Yu, Jessica A Davila, Fasiha Kanwal, Ziding Feng, Hashem B El-Serag
BACKGROUND: Hepatocellular carcinoma (HCC) has limited treatment options in patients with advanced stage disease and early detection of HCC through surveillance programs is a key component towards reducing mortality. The current practice guidelines recommend that high-risk cirrhosis patients are screened every six months with ultrasonography but these are done in local hospitals with variable quality leading to disagreement about the benefit of HCC surveillance. The well-established diagnostic biomarker α-Fetoprotein (AFP) is used widely in screening but the reported performance varies widely across studies...
January 4, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29299370/safety-of-selective-internal-radiation-therapy-sirt-with-yttrium-90-microspheres-combined-with-systemic-anticancer-agents-expert-consensus
#7
REVIEW
Andrew Kennedy, Daniel B Brown, Jonas Feilchenfeldt, John Marshall, Harpreet Wasan, Marwan Fakih, Peter Gibbs, Alexander Knuth, Bruno Sangro, Michael C Soulen, Gianfranco Pittari, Ricky A Sharma
Selective internal radiation therapy (SIRT) with microspheres labelled with the β-emitter yttrium-90 (Y-90) enables targeted delivery of radiation to hepatic tumors. SIRT is primarily used to treat inoperable primary or metastatic liver tumors. Eligible patients have usually been exposed to a variety of systemic anticancer therapies, including cytotoxic agents, targeted biologics, immunotherapy and peptide receptor radionuclide therapy (PRRT). All these treatments have potential interactions with SIRT; however, robust evidence on the safety of these potential combinations is lacking...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29288818/re-vaccination-following-autologous-hematopoietic-stem-cell-transplantation-is-safe-and-effective-in-patients-with-multiple-myeloma-receiving-lenalidomide-maintenance
#8
Meighan Palazzo, Gunjan L Shah, Olivia Copelan, Kenneth Seier, Sean M Devlin, Molly Maloy, Sheila Kenny, Hani Hassoun, Neha S Korde, Nikoletta Lendvai, Alexander M Lesokhin, Sham Mailankody, David J Chung, Guenther Koehne, C Ola Landgren, Heather Landau, Sergio A Giralt, Miguel-Angel Perales
Guidelines recommend vaccination starting 12 months after autologous hematopoietic stem cell transplant (aHCT), but there is varying practice for patients on maintenance therapy, with some centers not immunizing at all. Due to decreased vaccine rates among the general population causing loss of herd immunity, we aimed to establish the safety and efficacy of revaccinating multiple myeloma patients on lenalidomide maintenance (LM). Of the 122 patients who were vaccinated after aHCT between 2010-2014 at MSKCC, 91 (75%) were on LM...
December 27, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29281718/the-burden-of-hepatitis-b-virus-hbv-infection-genotypes-and-drug-resistance-mutations-in-human-immunodeficiency-virus-positive-patients-in-northwest-ethiopia
#9
Tekalign Deressa, Debasu Damtie, Kevin Fonseca, Shan Gao, Ebba Abate, Shitaye Alemu, Yetemwork Aleka, Mark G Swain, Guido van Marle, Carla S Coffin
BACKGROUND: In sub-Saharan Africa, the hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections are endemic. Although there has been great progress in HIV care, universal HBV vaccination and care is lacking. In this study, we aimed to determine the prevalence of HBV, HBV genotypes, and drug resistance mutations in dual infected cases in a cohort of HIV patients in Northwest Ethiopia. METHODS: A total of 308 HIV-1 positive patients were enrolled into the study and tested for HBsAg in plasma...
2017: PloS One
https://www.readbyqxmd.com/read/29276161/impact-of-vaccination-history-on-serological-testing-in-pregnant-women
#10
Michaël Desjardins, Isabelle Boucoiran, Caroline Paquet, Céline Laferrière, Anne Gosselin-Brisson, Annie-Claude Labbé, Valérie Martel-Laferrière
OBJECTIVE: Serological testing guidelines for vaccine-preventable infectious diseases in pregnant women are heterogeneous. It is unclear how vaccination history influences health care workers' (HCWs) attitudes about testing. The aim of this study was to describe current practices in screening for rubella, hepatitis B, and varicella-zoster virus (VZV) in pregnant women in the province of Québec. METHODS: In 2015, an electronic survey was distributed to HCWs who followed the case of at least one pregnant woman in the previous year and who could be contacted by email by their professional association...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29274174/prophylactic-antiviral-therapy-for-the-prevention-of-mother-to-child-transmission-of-hepatitis-b-virus-can-be-stopped-at-delivery
#11
Qing-Lei Zeng, Guang-Hua Xu, Ben Wang, Zhi-Qin Li, Zu-Jiang Yu
Many studies have demonstrated that antiviral therapy has an important role in the prevention of mother-to-child transmission of hepatitis B virus (HBV)1-3 , including a recent article by Han et al. who reported that the majority of mothers stopped prophylactic telbivudine at 1 month postpartum.4 However, the HBV Guidelines of the AASLD (at delivery to 3 months postpartum),1 EASL (within and at 12 weeks postpartum in 2012 and 2017, respectively),2 and APASL (at delivery)3 had different recommendations regarding stopping time of antivirals given as prophylaxis, which result in differing durations worldwide...
December 23, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29226097/guideline-of-prevention-and-treatment-for-chronic-hepatitis-b-2015-update
#12
Jinlin Hou, Guiqiang Wang, Fusheng Wang, Jun Cheng, Hong Ren, Hui Zhuang, Jian Sun, Lanjuan Li, Jie Li, Qinghua Meng, Jingmin Zhao, Zhongping Duan, Jidong Jia, Hong Tang, Jifang Sheng, Jie Peng, Fengmin Lu, Qing Xie, Lai Wei
No abstract text is available yet for this article.
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29218707/food-effect-on-rosuvastatin-disposition-and-low-density-lipoprotein-cholesterol
#13
Cheynne C McLean, Wendy A Teft, Bridget L Morse, Steven E Gryn, Robert A Hegele, Richard B Kim
Rosuvastatin is commonly prescribed for the treatment of hypercholesterolemia and hepatic transporter-mediated accumulation in the liver enhances its efficacy. Current guidelines indicate no preference for fed or fasted rosuvastatin administration. We investigated the association between food intake and rosuvastatin disposition in healthy subjects and low-density lipoprotein cholesterol (LDL-C) lowering effects among patients taking rosuvastatin. We demonstrate administration with food resulted in a near 40% reduction of rosuvastatin exposure in healthy Asian (n=12) and Caucasian (n=11) subjects...
December 8, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29209920/a-pilot-program-integrating-hepatitis-b-virus-hbv-screening-into-an-outpatient-endoscopy-unit-improves-hbv-screening-among-an-ethnically-diverse-safety-net-hospital
#14
Brendan Campbell, Aristeo Lopez, Benny Liu, Taft Bhuket, Robert J Wong
BACKGROUND: Safety-net hospitals are enriched in ethnic minorities and provide opportunities for high-impact hepatitis B virus (HBV) screening. AIM: We aim to evaluate the impact of a pilot program integrating HBV screening into outpatient endoscopy among urban safety-net populations. METHODS: From July 2015 to May 2017, consecutive adults undergoing outpatient endoscopy were prospectively assessed for HBV screening eligibility using US Preventative Services Task Force guidelines...
December 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29201774/hepatitis-action-plan-and-changing-trend-of-liver-disease-in-japan-viral-hepatitis-and-nonalcoholic-fatty-liver-disease
#15
REVIEW
Tatsuya Kanto, Sachiyo Yoshio
In Japan, the estimated number of chronic hepatitis B virus infections was 1.1 to 1.4 million, and that of chronic hepatitis C virus was 1.9 to 2.3 million in 2000. The mortality of hepatocellular carcinoma had been increasing and hit the peak at around 2002, which subsequently started to decrease. Japan has a national action plan for addressing viral hepatitis called Basic Act on Hepatitis Measures, established in 2009. In 2011, basic guidelines for promotion of control measures for hepatitis were issued, comprising nine principles in order to promote measures to prevent hepatitis B and C...
January 2017: Euroasian journal of hepato-gastroenterology
https://www.readbyqxmd.com/read/29181069/sorafenib-combined-with-hepatectomy-in-patients-with-intermediate-stage-and-advanced-hepatocellular-carcinoma
#16
Lei Zhuang, Tianfu Wen, Mingqing Xu, Jiayin Yang, Wentao Wang, Hong Wu, Yong Zeng, Lvnan Yan, Yonggang Wei, Bo Li
Introduction: Guidelines based on the Barcelona Clinic Liver Cancer (BCLC) classification system recommend that hepatic resection should be performed only in patients in BCLC stage A. Patients with stage B or stage C should receive palliative or no treatment. However, actual clinical practice varies, and a recent analysis of hepatocellular carcinoma (HCC) surgery outcomes in high volume surgical centers throughout the world concluded that hepatectomy can provide survival benefit for selected patients in all three BCLC stages...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29178118/midwives-educational-needs-and-knowledge-about-sexually-transmittable-infections-in-the-islamic-republic-of-iran
#17
Davoud Pourmarzi, Seyedeh Hajar Sharami
This study aimed to evaluate the educational needs and knowledge about sexually transmittable infections (STIs) demonstrated by midwives. In a cross-sectional study in 2014, 144 midwives in Rasht, Islamic Republic of Iran, were surveyed. The Persian version of the Sexually Transmitted Disease Knowledge Questionnaire (STD-KQ) and a researcher-made questionnaire to evaluate educational needs and profile were used. The participants obtained 74% of the total score of STD-KQ. Thirty-one percent of participants were categorized in high or very high need of education...
November 19, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29176657/dyslipidaemia-in-nephrotic-syndrome-mechanisms-and-treatment
#18
REVIEW
Shipra Agrawal, Joshua J Zaritsky, Alessia Fornoni, William E Smoyer
Nephrotic syndrome is a highly prevalent disease that is associated with high morbidity despite notable advances in its treatment. Many of the complications of nephrotic syndrome, including the increased risk of atherosclerosis and thromboembolism, can be linked to dysregulated lipid metabolism and dyslipidaemia. These abnormalities include elevated plasma levels of cholesterol, triglycerides and the apolipoprotein B-containing lipoproteins VLDL and IDL; decreased lipoprotein lipase activity in the endothelium, muscle and adipose tissues; decreased hepatic lipase activity; and increased levels of the enzyme PCSK9...
November 27, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29159414/hepatitis-b-vaccination-screening-and-linkage-to-care-best-practice-advice-from-the-american-college-of-physicians-and-the-centers-for-disease-control-and-prevention
#19
Winston E Abara, Amir Qaseem, Sarah Schillie, Brian J McMahon, Aaron M Harris
Background: Vaccination, screening, and linkage to care can reduce the burden of chronic hepatitis B virus (HBV) infection. However, recommendations vary among organizations, and their implementation has been suboptimal. The American College of Physicians' High Value Care Task Force and the Centers for Disease Control and Prevention developed this article to present best practice statements for hepatitis B vaccination, screening, and linkage to care. Methods: A narrative literature review of clinical guidelines, systematic reviews, randomized trials, and intervention studies on hepatitis B vaccination, screening, and linkage to care published between January 2005 and June 2017 was conducted...
November 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29145597/laboratory-testing-of-a-cohort-of-commercially-insured-users-of-hiv-preexposure-prophylaxis-in-the-united-states-2011-2015
#20
Ya-Lin A Huang, Guoyu Tao, Taraz Samandari, Karen W Hoover
To ensure the health and safety of persons taking antiretroviral medication for HIV preexposure prophylaxis (PrEP), CDC guidelines recommend initial and follow-up laboratory testing. We assessed the rates of recommended testing using a commercial insurance claims database. Before taking PrEP, 45% of users were tested for HIV, 31% for creatinine, 55% for syphilis, 43% for chlamydia/gonorrhea, and 38% for hepatitis B. By 6 months after PrEP initiation, 38% were tested for HIV, 37% for creatinine, 49% for syphilis, and 39% for chlamydia/gonorrhea...
November 14, 2017: Journal of Infectious Diseases
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