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thulin 2015

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https://www.readbyqxmd.com/read/26660725/tasquinimod-inhibits-prostate-cancer-growth-in-bone-through-alterations-in-the-bone-microenvironment
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Lisa U Magnusson, Malin Hagberg Thulin, Pascale Plas, Anders Olsson, Jan-Erik Damber, Karin Welén
BACKGROUND: Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that inhibits occurrence of experimental metastasis and delays disease progression of castration resistant prostate cancer in humans. Its mechanism of action is not fully elucidated, but previous studies show immunomodulatory and anti-angiogenic effects. The aim of the present study was to investigate the tumor inhibiting effect of tasquinimod in bone of castrated mice as well as to elucidate its working mechanism related to bone microenvironment...
March 2016: Prostate
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